2023

Bachmaier, S., Gould, M. K., Polatoglou, E., Omelianczyk, R., Brennand, A. E., Aloraini, M. A., Munday, J. C. , Horn, D., Boshart, M. and De Koning, H. (2023) Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in T. brucei. Frontiers in Cellular and Infection Microbiology, 13, 1204707. (doi: 10.3389/fcimb.2023.1204707) (PMID:37475965) (PMCID:PMC10354285)

2021

Natto, M. J., Miyamoto, Y., Munday, J. C. , AlSiari, T. A., Al-Salabi, M. I., Quashie, N. B., Eze, A. A., Eckmann, L. and De Koning, H. P. (2021) Comprehensive characterisation of purine and pyrimidine transport activities in Trichomonas vaginalis and functional cloning of a trichomonad nucleoside transporter. Molecular Microbiology, 116(6), pp. 1489-1511. (doi: 10.1111/mmi.14840) (PMID:34738285)

Carruthers, L. V. et al. (2021) Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential. Molecular Microbiology, 116(2), pp. 564-588. (doi: 10.1111/mmi.14733) (PMID:33932053)

2020

Munday, J. C. et al. (2020) Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages. PLoS Neglected Tropical Diseases, 14(7), e0008447. (doi: 10.1371/journal.pntd.0008447) (PMID:32730343) (PMCID:PMC7430754)

De Araújo, J. S. et al. (2020) Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi. Journal of Antimicrobial Chemotherapy, 75(4), pp. 958-967. (doi: 10.1093/jac/dkz516) (PMID:31860098)

Alghamdi, A. et al. (2020) Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei. eLife, 9, e56416. (doi: 10.7554/eLife.56416) (PMID:32762841) (PMCID:PMC7473772)

2019

Sebastián-Pérez, V. et al. (2019) Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis. Future Medicinal Chemistry, 11(14), pp. 1703-1720. (doi: 10.4155/fmc-2018-0592) (PMID:31370708)

Botros, S. S. et al. (2019) Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity. International Journal for Parasitology: Drugs and Drug Resistance, 9, pp. 35-43. (doi: 10.1016/j.ijpddr.2019.01.001)

Giordani, F. , Khalaf, A. I., Gillingwater, K., Munday, J. C. , de Koning, H. P. , Suckling, C. J., Barrett, M. P. and Scott, F. J. (2019) Novel minor groove binders cure animal African trypanosomiasis in an in vivo mouse model. Journal of Medicinal Chemistry, 62(6), pp. 3021-3035. (doi: 10.1021/acs.jmedchem.8b01847) (PMID:30763102)

2018

Sebastián-Pérez, V., Hendrickx, S., Munday, J. C. , Kalejaiye, T., Martínez, A., Campillo, N. E., de Koning, H. , Caljon, G., Maes, L. and Gil, C. (2018) Cyclic nucleotide specific phosphodiesterases as potential drug targets for anti-Leishmania therapy. Antimicrobial Agents and Chemotherapy, 62(10), e00603-18. (doi: 10.1128/AAC.00603-18) (PMID:30104270)

Blaazer, A. R. et al. (2018) Targeting a subpocket in Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) enables the structure-based discovery of selective Inhibitors with trypanocidal activity. Journal of Medicinal Chemistry, 61(9), pp. 3870-3888. (doi: 10.1021/acs.jmedchem.7b01670) (PMID:29672041) (PMCID:PMC5949723)

Campagnaro, G. D., Alzahrani, K. J., Munday, J. C. and De Koning, H. P. (2018) Trypanosoma brucei bloodstream forms express highly specific and separate transporters for adenine and hypoxanthine; evidence for a new protozoan purine transporter family? Molecular and Biochemical Parasitology, 220, pp. 46-56. (doi: 10.1016/j.molbiopara.2018.01.005) (PMID:29371154)

2016

Eze, A. A., Gould, M. K., Munday, J. C. , Tagoe, D. N.A., Stelmanis, V., Schnaufer, A. and De Koning, H. P. (2016) Reduced mitochondrial membrane potential is a late adaptation of trypanosoma brucei brucei to isometamidium preceded by mutations in the γ subunit of the F1Fo-ATPase. PLoS Neglected Tropical Diseases, 10(8), e0004791. (doi: 10.1371/journal.pntd.0004791) (PMID:27518185) (PMCID:PMC4982688)

Graf, F. E. et al. (2016) Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. Cellular and Molecular Life Sciences, 73(17), pp. 3387-3400. (doi: 10.1007/s00018-016-2173-6) (PMID:26973180) (PMCID:PMC4967103)

2015

Graf, F. E., Baker, N., Munday, J. C. , De Koning, H. P. , Horn, D. and Mäser, P. (2015) Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates. International Journal for Parasitology: Drugs and Drug Resistance, 5(2), pp. 65-68. (doi: 10.1016/j.ijpddr.2015.04.002) (PMID:26042196) (PMCID:PMC4443405)

Munday, J. C. et al. (2015) Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei Adenosine Transporter 1 (TbAT1) and the proposal of a structural model for the protein. Molecular Microbiology, 96(4), pp. 887-900. (doi: 10.1111/mmi.12979) (PMID:25708978) (PMCID:PMC4755147)

Munday, J. C. , Settimo, L. and De Koning, H. P. (2015) Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei. Frontiers in Pharmacology, 6, 32. (doi: 10.3389/fphar.2015.00032) (PMID:24235095) (PMCID:PMC3922157)

2014

Munday, J. C. et al. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. Journal of Antimicrobial Chemotherapy, 69(3), pp. 651-663. (doi: 10.1093/jac/dkt442) (PMID:24235095) (PMCID:PMC3922157)

Garcia-Salcedo, J. A., Munday, J. C. , Unciti-Broceta, J. D. and De Koning, H. P. (2014) Progress towards new treatments for human African trypanosomiasis. In: Magez, S. and Radwanska, M. (eds.) Trypanosomes and Trypanosomiasis. Springer, pp. 217-238. ISBN 9783709115558 (doi: 10.1007/978-3-7091-1556-5_9)

2013

Munday, J.C. , Rojas López, K.E., Eze, A.A., Delespaux, V., Van Den Abbeele, J., Rowan, T., Barrett, M.P. , Morrison, L.J. and De Koning, H.P. (2013) Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake. International Journal for Parasitology: Drugs and Drug Resistance, 3, pp. 69-76. (doi: 10.1016/j.ijpddr.2013.01.004)

Gould, M.K., Bachmaier, S., Ali, J.A.M., Alsford, S., Tagoe, D.N.A., Munday, J.C. , Schnaufer, A.C., Horn, D., Boshart, M. and De Koning, H. (2013) Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA. Antimicrobial Agents and Chemotherapy, 57(10), pp. 4882-4893. (doi: 10.1128/AAC.00508-13)

Ali, J. A.., Tagoe, D. N.A., Munday, J. C. , Donachie, A., Morrison, L. J. and De Koning, H. P. (2013) Pyrimidine biosynthesis is not an essential function for trypanosoma brucei bloodstream forms. PLoS ONE, 8(3), e58034. (doi: 10.1371/journal.pone.0058034) (PMID:23505454) (PMCID:PMC3591441)

2012

Baker, N., Glover, L., Munday, J. C. , Aguinaga Andres, D., Barrett, M. P. , De Koning, H. P. and Horn, D. (2012) Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 109(27), pp. 10996-11001. (doi: 10.1073/pnas.1202885109)

2011

Teka, I. A. et al. (2011) The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Molecular Pharmacology, 80(1), pp. 110-116. (doi: 10.1124/mol.111.071555)

Munday, J. C. , McLuskey, K., Brown, E., Coombs, G. H. and Mottram, J. C. (2011) Oligopeptidase B deficient mutants of Leishmania major. Molecular and Biochemical Parasitology, 175(1), pp. 49-57. (doi: 10.1016/j.molbiopara.2010.09.003)

Articles

Bachmaier, S., Gould, M. K., Polatoglou, E., Omelianczyk, R., Brennand, A. E., Aloraini, M. A., Munday, J. C. , Horn, D., Boshart, M. and De Koning, H. (2023) Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in T. brucei. Frontiers in Cellular and Infection Microbiology, 13, 1204707. (doi: 10.3389/fcimb.2023.1204707) (PMID:37475965) (PMCID:PMC10354285)

Natto, M. J., Miyamoto, Y., Munday, J. C. , AlSiari, T. A., Al-Salabi, M. I., Quashie, N. B., Eze, A. A., Eckmann, L. and De Koning, H. P. (2021) Comprehensive characterisation of purine and pyrimidine transport activities in Trichomonas vaginalis and functional cloning of a trichomonad nucleoside transporter. Molecular Microbiology, 116(6), pp. 1489-1511. (doi: 10.1111/mmi.14840) (PMID:34738285)

Carruthers, L. V. et al. (2021) Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential. Molecular Microbiology, 116(2), pp. 564-588. (doi: 10.1111/mmi.14733) (PMID:33932053)

Munday, J. C. et al. (2020) Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages. PLoS Neglected Tropical Diseases, 14(7), e0008447. (doi: 10.1371/journal.pntd.0008447) (PMID:32730343) (PMCID:PMC7430754)

De Araújo, J. S. et al. (2020) Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi. Journal of Antimicrobial Chemotherapy, 75(4), pp. 958-967. (doi: 10.1093/jac/dkz516) (PMID:31860098)

Alghamdi, A. et al. (2020) Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei. eLife, 9, e56416. (doi: 10.7554/eLife.56416) (PMID:32762841) (PMCID:PMC7473772)

Sebastián-Pérez, V. et al. (2019) Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis. Future Medicinal Chemistry, 11(14), pp. 1703-1720. (doi: 10.4155/fmc-2018-0592) (PMID:31370708)

Botros, S. S. et al. (2019) Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity. International Journal for Parasitology: Drugs and Drug Resistance, 9, pp. 35-43. (doi: 10.1016/j.ijpddr.2019.01.001)

Giordani, F. , Khalaf, A. I., Gillingwater, K., Munday, J. C. , de Koning, H. P. , Suckling, C. J., Barrett, M. P. and Scott, F. J. (2019) Novel minor groove binders cure animal African trypanosomiasis in an in vivo mouse model. Journal of Medicinal Chemistry, 62(6), pp. 3021-3035. (doi: 10.1021/acs.jmedchem.8b01847) (PMID:30763102)

Sebastián-Pérez, V., Hendrickx, S., Munday, J. C. , Kalejaiye, T., Martínez, A., Campillo, N. E., de Koning, H. , Caljon, G., Maes, L. and Gil, C. (2018) Cyclic nucleotide specific phosphodiesterases as potential drug targets for anti-Leishmania therapy. Antimicrobial Agents and Chemotherapy, 62(10), e00603-18. (doi: 10.1128/AAC.00603-18) (PMID:30104270)

Blaazer, A. R. et al. (2018) Targeting a subpocket in Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) enables the structure-based discovery of selective Inhibitors with trypanocidal activity. Journal of Medicinal Chemistry, 61(9), pp. 3870-3888. (doi: 10.1021/acs.jmedchem.7b01670) (PMID:29672041) (PMCID:PMC5949723)

Campagnaro, G. D., Alzahrani, K. J., Munday, J. C. and De Koning, H. P. (2018) Trypanosoma brucei bloodstream forms express highly specific and separate transporters for adenine and hypoxanthine; evidence for a new protozoan purine transporter family? Molecular and Biochemical Parasitology, 220, pp. 46-56. (doi: 10.1016/j.molbiopara.2018.01.005) (PMID:29371154)

Eze, A. A., Gould, M. K., Munday, J. C. , Tagoe, D. N.A., Stelmanis, V., Schnaufer, A. and De Koning, H. P. (2016) Reduced mitochondrial membrane potential is a late adaptation of trypanosoma brucei brucei to isometamidium preceded by mutations in the γ subunit of the F1Fo-ATPase. PLoS Neglected Tropical Diseases, 10(8), e0004791. (doi: 10.1371/journal.pntd.0004791) (PMID:27518185) (PMCID:PMC4982688)

Graf, F. E. et al. (2016) Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. Cellular and Molecular Life Sciences, 73(17), pp. 3387-3400. (doi: 10.1007/s00018-016-2173-6) (PMID:26973180) (PMCID:PMC4967103)

Graf, F. E., Baker, N., Munday, J. C. , De Koning, H. P. , Horn, D. and Mäser, P. (2015) Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates. International Journal for Parasitology: Drugs and Drug Resistance, 5(2), pp. 65-68. (doi: 10.1016/j.ijpddr.2015.04.002) (PMID:26042196) (PMCID:PMC4443405)

Munday, J. C. et al. (2015) Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei Adenosine Transporter 1 (TbAT1) and the proposal of a structural model for the protein. Molecular Microbiology, 96(4), pp. 887-900. (doi: 10.1111/mmi.12979) (PMID:25708978) (PMCID:PMC4755147)

Munday, J. C. , Settimo, L. and De Koning, H. P. (2015) Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei. Frontiers in Pharmacology, 6, 32. (doi: 10.3389/fphar.2015.00032) (PMID:24235095) (PMCID:PMC3922157)

Munday, J. C. et al. (2014) Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs. Journal of Antimicrobial Chemotherapy, 69(3), pp. 651-663. (doi: 10.1093/jac/dkt442) (PMID:24235095) (PMCID:PMC3922157)

Munday, J.C. , Rojas López, K.E., Eze, A.A., Delespaux, V., Van Den Abbeele, J., Rowan, T., Barrett, M.P. , Morrison, L.J. and De Koning, H.P. (2013) Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake. International Journal for Parasitology: Drugs and Drug Resistance, 3, pp. 69-76. (doi: 10.1016/j.ijpddr.2013.01.004)

Gould, M.K., Bachmaier, S., Ali, J.A.M., Alsford, S., Tagoe, D.N.A., Munday, J.C. , Schnaufer, A.C., Horn, D., Boshart, M. and De Koning, H. (2013) Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA. Antimicrobial Agents and Chemotherapy, 57(10), pp. 4882-4893. (doi: 10.1128/AAC.00508-13)

Ali, J. A.., Tagoe, D. N.A., Munday, J. C. , Donachie, A., Morrison, L. J. and De Koning, H. P. (2013) Pyrimidine biosynthesis is not an essential function for trypanosoma brucei bloodstream forms. PLoS ONE, 8(3), e58034. (doi: 10.1371/journal.pone.0058034) (PMID:23505454) (PMCID:PMC3591441)

Baker, N., Glover, L., Munday, J. C. , Aguinaga Andres, D., Barrett, M. P. , De Koning, H. P. and Horn, D. (2012) Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes. Proceedings of the National Academy of Sciences of the United States of America, 109(27), pp. 10996-11001. (doi: 10.1073/pnas.1202885109)

Teka, I. A. et al. (2011) The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Molecular Pharmacology, 80(1), pp. 110-116. (doi: 10.1124/mol.111.071555)

Munday, J. C. , McLuskey, K., Brown, E., Coombs, G. H. and Mottram, J. C. (2011) Oligopeptidase B deficient mutants of Leishmania major. Molecular and Biochemical Parasitology, 175(1), pp. 49-57. (doi: 10.1016/j.molbiopara.2010.09.003)

Book Sections

Garcia-Salcedo, J. A., Munday, J. C. , Unciti-Broceta, J. D. and De Koning, H. P. (2014) Progress towards new treatments for human African trypanosomiasis. In: Magez, S. and Radwanska, M. (eds.) Trypanosomes and Trypanosomiasis. Springer, pp. 217-238. ISBN 9783709115558 (doi: 10.1007/978-3-7091-1556-5_9)