Dr Giuditta De Lorenzo
- Affiliate (School of Infection & Immunity)
https://orcid.org/0000-0002-2736-8740Publications
2024
Tandavanitj, R., Setthapramote, C., De Lorenzo, G. , Sanchez-Velazquez, R., Clark, J. J., Rocchi, M., McInnes, C., Kohl, A. and Patel, A. H. (2024) Virus-like particles of louping ill virus elicit potent neutralizing antibodies targeting multimers of viral envelope protein. Vaccine, 42(9), pp. 2429-2437. (doi: 10.1016/j.vaccine.2024.03.008) (PMID:38458875)
Furnon, W. , Cowton, V., De Lorenzo, G. , Patel, A. and Palmarini, M. (2024) Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants. Nature Microbiology, 9, pp. 451-463. (doi: 10.1038/s41564-023-01588-4) (PMID:38228858) (PMCID:PMC10847042)
2023
Meehan, G. R. et al. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. PLoS Pathogens, 19(11), e1011589. (doi: 10.1371/journal.ppat.1011589) (PMID:37934791) (PMCID:PMC10656012)
Bouhaddou, M. et al. (2023) SARS-CoV-2 variants evolve convergent strategies to remodel the host response. Cell, 186(21), pp. 4597-4614. (doi: 10.1016/j.cell.2023.08.026) (PMID:37738970) (PMCID:PMC10604369)
Wallace, S. et al. (2023) Multiplexed biosensing of proteins and virions with disposable plasmonic assays. ACS Sensors, 8(9), pp. 3338-3348. (doi: 10.1021/acssensors.2c02238) (PMID:37610841) (PMCID:PMC10521139)
da Silva Sanches, P. R., Sanchez-Velazquez, R., Nogueira Batista, M., Moreira Carneiro, B., Bittar, C., De Lorenzo, G. , Rahal, P., Patel, A. H. and Maffud Cilli, E. (2023) Antiviral evaluation of new synthetic bioconjugates based on GA-Hecate: A new class of antivirals targeting different steps of Zika Virus replication. Molecules, 28(13), 4884. (doi: 10.3390/molecules28134884) (PMID:37446546) (PMCID:PMC10343505)
Mancini, M. V. et al. (2023) Evaluation of an engineered Zika virus-like particle vaccine candidate in a mosquito-mouse transmission model. mSphere, 8(2), e00564-22. (doi: 10.1128/msphere.00564-22) (PMID:36840596) (PMCID:PMC10117074)
2022
Lista, M. J. et al. (2022) The P681H mutation in the spike glycoprotein of the alpha variant of SARS-CoV-2 escapes IFITM restriction and is necessary for type I interferon resistance. Journal of Virology, 96(23), e0125022. (doi: 10.1128/jvi.01250-22) (PMID:36350154) (PMCID:PMC9749455)
Willett, B. J. et al. (2022) Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7, 1709. (doi: 10.1038/s41564-022-01241-6) (PMID:36114232) (PMCID:PMC9483304)
Willett, B. J. et al. (2022) SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7(8), pp. 1161-1179. (doi: 10.1038/s41564-022-01143-7) (PMID:35798890) (PMCID:PMC9352574)
Zhou, J. et al. (2022) Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Cell Reports, 38(6), 110344. (doi: 10.1016/j.celrep.2022.110344) (PMID:35093235) (PMCID:PMC8768428)
2021
Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)
De Lorenzo, G. et al. (2021) Zika virus-like particles bearing covalent dimer of envelope protein protect mice from lethal challenge. Journal of Virology, 95(1), e01415-20. (doi: 10.1128/JVI.01415-20) (PMID:33028720) (PMCID:PMCID: PMC7737734)
2020
Sanchez Velazquez, R. et al. (2020) Generation of a reporter yellow fever virus for high throughput antiviral assays. Antiviral Research, 183, 104939. (doi: 10.1016/j.antiviral.2020.104939) (PMID:32980446) (PMCID:PMC7649875)
Banerjee, A. K. et al. (2020) SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses. Cell, (doi: 10.1016/j.cell.2020.10.004) (PMID:33080218) (PMCID:PMC7543886)
López-Camacho, C. et al. (2020) Immunogenicity and efficacy of Zika virus Envelope Domain III in DNA, protein and ChAdOx1 adenoviral-vectored vaccines. Vaccines, 8(2), 307. (doi: 10.3390/vaccines8020307) (PMID:32560145)
2018
López-Camacho, C. et al. (2018) Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors. Nature Communications, 9, 2441. (doi: 10.1038/s41467-018-04859-5) (PMID:29934593) (PMCID:PMC6015009)
Eichwald, C. et al. (2018) Identification of a small molecule that compromises the structural integrity of viroplasms and rotavirus double-layered particles. Journal of Virology, 92(3), e01943-17. (doi: 10.1128/JVI.01943-17) (PMID:29142132) (PMCID:PMC5774888)
2016
Ziberna, F. et al. (2016) Lack of evidence of rotavirus‐dependent molecular mimicry as a trigger of coeliac disease. Clinical and Experimental Immunology, 186(3), pp. 356-363. (doi: 10.1111/cei.12855) (PMID:27548641)
De Lorenzo, G. , Drikic, M., Papa, G., Eichwald, C., Burrone, O. R. and Arnoldi, F. (2016) An inhibitory motif on the 5'UTR of several rotavirus genome segments affects protein expression and reverse genetics strategies. PLoS ONE, 11(11), e0166719. (doi: 10.1371/journal.pone.0166719) (PMID:27846320) (PMCID:PMC5112996)
2014
Arnoldi, F., De Lorenzo, G. , Mano, M., Schraner, E. M., Wild, P., Eichwald, C. and Burrone, O. R. (2014) Rotavirus increases levels of lipidated LC3 supporting accumulation of infectious progeny virus without inducing autophagosome formation. PLoS ONE, 9(4), e95197. (doi: 10.1371/journal.pone.0095197) (PMID:24736649) (PMCID:PMC3988245)
2012
De Lorenzo, G. , Eichwald, C., Schraner, E.M., Nicolin, V., Bortul, R., Mano, M., Burrone, O.R. and Arnoldi, F. (2012) Production of in vivo-biotinylated rotavirus particles. Journal of General Virology, 93(7), pp. 1474-1482. (doi: 10.1099/vir.0.040089-0) (PMID:22442113)
Articles
Tandavanitj, R., Setthapramote, C., De Lorenzo, G. , Sanchez-Velazquez, R., Clark, J. J., Rocchi, M., McInnes, C., Kohl, A. and Patel, A. H. (2024) Virus-like particles of louping ill virus elicit potent neutralizing antibodies targeting multimers of viral envelope protein. Vaccine, 42(9), pp. 2429-2437. (doi: 10.1016/j.vaccine.2024.03.008) (PMID:38458875)
Furnon, W. , Cowton, V., De Lorenzo, G. , Patel, A. and Palmarini, M. (2024) Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants. Nature Microbiology, 9, pp. 451-463. (doi: 10.1038/s41564-023-01588-4) (PMID:38228858) (PMCID:PMC10847042)
Meehan, G. R. et al. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. PLoS Pathogens, 19(11), e1011589. (doi: 10.1371/journal.ppat.1011589) (PMID:37934791) (PMCID:PMC10656012)
Bouhaddou, M. et al. (2023) SARS-CoV-2 variants evolve convergent strategies to remodel the host response. Cell, 186(21), pp. 4597-4614. (doi: 10.1016/j.cell.2023.08.026) (PMID:37738970) (PMCID:PMC10604369)
Wallace, S. et al. (2023) Multiplexed biosensing of proteins and virions with disposable plasmonic assays. ACS Sensors, 8(9), pp. 3338-3348. (doi: 10.1021/acssensors.2c02238) (PMID:37610841) (PMCID:PMC10521139)
da Silva Sanches, P. R., Sanchez-Velazquez, R., Nogueira Batista, M., Moreira Carneiro, B., Bittar, C., De Lorenzo, G. , Rahal, P., Patel, A. H. and Maffud Cilli, E. (2023) Antiviral evaluation of new synthetic bioconjugates based on GA-Hecate: A new class of antivirals targeting different steps of Zika Virus replication. Molecules, 28(13), 4884. (doi: 10.3390/molecules28134884) (PMID:37446546) (PMCID:PMC10343505)
Mancini, M. V. et al. (2023) Evaluation of an engineered Zika virus-like particle vaccine candidate in a mosquito-mouse transmission model. mSphere, 8(2), e00564-22. (doi: 10.1128/msphere.00564-22) (PMID:36840596) (PMCID:PMC10117074)
Lista, M. J. et al. (2022) The P681H mutation in the spike glycoprotein of the alpha variant of SARS-CoV-2 escapes IFITM restriction and is necessary for type I interferon resistance. Journal of Virology, 96(23), e0125022. (doi: 10.1128/jvi.01250-22) (PMID:36350154) (PMCID:PMC9749455)
Willett, B. J. et al. (2022) Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7, 1709. (doi: 10.1038/s41564-022-01241-6) (PMID:36114232) (PMCID:PMC9483304)
Willett, B. J. et al. (2022) SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway. Nature Microbiology, 7(8), pp. 1161-1179. (doi: 10.1038/s41564-022-01143-7) (PMID:35798890) (PMCID:PMC9352574)
Zhou, J. et al. (2022) Mutations that adapt SARS-CoV-2 to mink or ferret do not increase fitness in the human airway. Cell Reports, 38(6), 110344. (doi: 10.1016/j.celrep.2022.110344) (PMID:35093235) (PMCID:PMC8768428)
Rihn, S. J. et al. (2021) A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology, 19(2), e3001091. (doi: 10.1371/journal.pbio.3001091) (PMID:33630831) (PMCID:PMC7906417)
De Lorenzo, G. et al. (2021) Zika virus-like particles bearing covalent dimer of envelope protein protect mice from lethal challenge. Journal of Virology, 95(1), e01415-20. (doi: 10.1128/JVI.01415-20) (PMID:33028720) (PMCID:PMCID: PMC7737734)
Sanchez Velazquez, R. et al. (2020) Generation of a reporter yellow fever virus for high throughput antiviral assays. Antiviral Research, 183, 104939. (doi: 10.1016/j.antiviral.2020.104939) (PMID:32980446) (PMCID:PMC7649875)
Banerjee, A. K. et al. (2020) SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses. Cell, (doi: 10.1016/j.cell.2020.10.004) (PMID:33080218) (PMCID:PMC7543886)
López-Camacho, C. et al. (2020) Immunogenicity and efficacy of Zika virus Envelope Domain III in DNA, protein and ChAdOx1 adenoviral-vectored vaccines. Vaccines, 8(2), 307. (doi: 10.3390/vaccines8020307) (PMID:32560145)
López-Camacho, C. et al. (2018) Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors. Nature Communications, 9, 2441. (doi: 10.1038/s41467-018-04859-5) (PMID:29934593) (PMCID:PMC6015009)
Eichwald, C. et al. (2018) Identification of a small molecule that compromises the structural integrity of viroplasms and rotavirus double-layered particles. Journal of Virology, 92(3), e01943-17. (doi: 10.1128/JVI.01943-17) (PMID:29142132) (PMCID:PMC5774888)
Ziberna, F. et al. (2016) Lack of evidence of rotavirus‐dependent molecular mimicry as a trigger of coeliac disease. Clinical and Experimental Immunology, 186(3), pp. 356-363. (doi: 10.1111/cei.12855) (PMID:27548641)
De Lorenzo, G. , Drikic, M., Papa, G., Eichwald, C., Burrone, O. R. and Arnoldi, F. (2016) An inhibitory motif on the 5'UTR of several rotavirus genome segments affects protein expression and reverse genetics strategies. PLoS ONE, 11(11), e0166719. (doi: 10.1371/journal.pone.0166719) (PMID:27846320) (PMCID:PMC5112996)
Arnoldi, F., De Lorenzo, G. , Mano, M., Schraner, E. M., Wild, P., Eichwald, C. and Burrone, O. R. (2014) Rotavirus increases levels of lipidated LC3 supporting accumulation of infectious progeny virus without inducing autophagosome formation. PLoS ONE, 9(4), e95197. (doi: 10.1371/journal.pone.0095197) (PMID:24736649) (PMCID:PMC3988245)
De Lorenzo, G. , Eichwald, C., Schraner, E.M., Nicolin, V., Bortul, R., Mano, M., Burrone, O.R. and Arnoldi, F. (2012) Production of in vivo-biotinylated rotavirus particles. Journal of General Virology, 93(7), pp. 1474-1482. (doi: 10.1099/vir.0.040089-0) (PMID:22442113)
Research datasets
2024
Furnon, W. , Cowton, V. M., De Lorenzo, G. , Orton, R. , Herder, V. , Cantoni, D. , Ilia, G., Correa Mendonca, D. , Kerr, K., Allan, J., Upfold, N. , Meehan, G. R. , Bakshi, S., Das, U. R., Molina Arias, S., McElwee, M., Little, S., Logan, N., Kwok, K. , Smollett, K. , Willett, B. , Da Silva Filipe, A. , Robertson, D. L. , Grove, J. , Patel, A. H. and Palmarini, M. (2024) Phenotypic evolution of SARS-CoV-2 spike throughout the COVID-19 pandemic. [Data Collection]
2023
Meehan, G. , Herder, V. , Allan, J., Huang, X., Kerr, K., Correa Mendonca, D. , Ilia, G., Wright, D. , Nomikou, K., Gu, Q. , Molina Arias, S., Hansmann, F., Hardas, A., Attipa, C., De Lorenzo, G. , Cowton, V., Upfold, N. , Palmalux, N., Brown, J., Barclay, W., Da Silva Filipe, A. , Furnon, W. , Patel, A. and Palmarini, M. (2023) Phenotyping the virulence of SARS-CoV-2 variants in hamsters by digital pathology and machine learning. [Data Collection]