Dr STEFANO ALIVERNINI
- Honorary Professor (School of Infection & Immunity)
Publications
2024
Alivernini, S., Cañete, J. D., Bacardit, J. and Kurowska-Stolarska, M. (2024) Using explainable artificial intelligence to predict and forestall flare in rheumatoid arthritis. Nature Medicine, 30(4), pp. 925-926. (doi: 10.1038/s41591-024-02818-w) (PMID:38361121)
Coletto, L. A., Marino, V., Rizzo, C., Bruno, D., Caporali, R., Gremese, E., D'Agostino, M. A. and Alivernini, S. (2024) Intensive training programme for ultrasound-guided minimally invasive synovial tissue biopsy on knees and wrists in different phases of inflammation. RMD Open, 10(1), e003705. (doi: 10.1136/rmdopen-2023-003705) (PMID:38351051) (PMCID:PMC10868172)
2022
Najm, A. et al. (2022) EULAR Points to consider for minimal reporting requirements in synovial tissue research in rheumatology. Annals of the Rheumatic Diseases, 81(12), pp. 1640-1646. (doi: 10.1136/annrheumdis-2021-221875) (PMID:35210263)
Kurowska-Stolarska, M. and Alivernini, S. (2022) Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission. Nature Reviews Rheumatology, 18, pp. 384-397. (doi: 10.1038/s41584-022-00790-8) (PMID:35672464)
Farina, L. et al. (2022) Pro nerve growth factor and its receptor p75NTR activate inflammatory responses in synovial fibroblasts: a novel targetable mechanism in arthritis. Frontiers in Immunology, 13, 818630. (doi: 10.3389/fimmu.2022.818630) (PMID:35309353) (PMCID:PMC8931659)
2021
Clayton, S. A. et al. (2021) Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48. Science Advances, 7(50), eabl5182. (doi: 10.1126/sciadv.abl5182) (PMID:34878835)
MacDonald, L. et al. (2021) COVID-19 and RA share SPP1 myeloid pathway that drives PD-L1pos neutrophils and CD14pos monocytes. JCI Insight, 6(13), e147413. (doi: 10.1172/jci.insight.147413) (PMID:34143756) (PMCID:PMC8328085)
Wang, Y. et al. (2021) Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis. Nature Communications, 12, 2343. (doi: 10.1038/s41467-021-22365-z) (PMID:33879788) (PMCID:PMC8058094)
2020
Alivernini, S. et al. (2020) Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nature Medicine, 26(8), pp. 1295-1306. (doi: 10.1038/s41591-020-0939-8) (PMID:32601335)
2019
Finlay, S. et al. (2019) Presence of the MerTK Receptor on Human Synovial Tissue Macrophages Lowers Inflammatory Cytokine Production and Activation of the MerTK+CD206+ Subpopulation Limits the Inflammatory Response of Synovial Fibroblasts. 2019 ACR/ARP Annual Meeting, Atlanta, GA, USA, 08-13 Nov 2019.
Elmesmari, A. et al. (2019) Do Functional Interactions Between Macrophages and Synovial Fibroblasts Drive Synovial Pathology or Resolution of Inflammation? European League Against Rheumatism (EULAR) 2019 Congress, Madrid, Spain, 12-15 Jun 2019.
Finlay, S. et al. (2019) Single-cell Transcriptomic and Functional Analyses Reveal Novel Heterogeneity in Pathogenic Pathways Mediated by Human Synovial Tissue Macrophages. European League Against Rheumatism (EULAR) 2019 Congress, Madrid, Spain, 12-15 Jun 2019.
2018
Alivernini, S. et al. (2018) Histological Features and Tissue-Macrophage Phenotype of Synovial Biopsies Identify RA Patients in Sustained Remission at Risk of Disease Flare after Treatment Tapering or Discontinuation. 2018 ACR/ARHP Annual Meeting, Chicago, IL, 19-24 Oct 2018. (Unpublished)
Alivernini, S., Tolusso, B., Ferraccioli, G., Gremese, E., Kurowska-Stolarska, M. and McInnes, I.B. (2018) Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells. Clinical and Experimental Immunology, 193(1), pp. 13-23. (doi: 10.1111/cei.13098) (PMID:29315512) (PMCID:PMC6038003)
Elmesmari, A., Alivernini, S., Tolusso, B., Bui, L., Vaughan, D. , Federico, F., Gremese, E., McInnes, I. B. and Kurowska-Stolarska, M. (2018) Stolarska Synovial Tissue CD1c+ Dendritic Cells in Rheumatoid Arthritis Express High Levels of the Epigenetic Regulator of Inflammation, Microrna-155 and Inflammatory Cytokines. EULAR 2018: Annual European Congress of Rheumatology, Amsterdam, Netherlands, 13-16 June 2018. (Unpublished)
Finlay, S., Alivernini, S., Elmesmari, A., Tolusso, B., Ferraccioli, G., Gremese, E., Petricca, L., McInnes, I. B. , Kurowska-Stolarska, M. and Filer, A. (2018) Activation of Mertk+cd206+ Subpopulation of Human Synovial Tissue-Resident Macrophages Limits Inflammatory Response. EULAR 2018: Annual European Congress of Rheumatology, Amsterdam, Netherlands, 13-16 June 2018. (Unpublished)
Alivernini, S., Gremese, E., McSharry, C., Tolusso, B., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2018) MicroRNA-155—at the critical interface of innate and adaptive immunity in arthritis. Frontiers in Immunology, 8, 1932. (doi: 10.3389/fimmu.2017.01932) (PMID:29354135) (PMCID:PMC5760508)
Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. , Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2018) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. Microphage Biology in the Single-Cell Era, Ghent, Belgium, 2018. (Unpublished)
2017
Kurowska-Stolarska, M. and Alivernini, S. (2017) Synovial tissue macrophages: friend or foe? RMD Open, 3(2), e000527. (doi: 10.1136/rmdopen-2017-000527) (PMID:29299338) (PMCID:PMC5729306)
Kurowska-Stolarska, M. et al. (2017) MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. Nature Communications, 8, 15877. (doi: 10.1038/ncomms15877) (PMID:28639625) (PMCID:PMC5489689)
Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. , Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2017) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. EULAR 2017: Annual European Congress of Rheumatology, Madrid, Spain, 14-17 June 2017. (Unpublished)
Elmesmari, A., Alivernini, S., Vaughan, D. , Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2017) Characterisation of Synovium Tissues Macropahges. Rheumatology 2017, Birmingham, UK, 25-27 April 2017. (Unpublished)
Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. , Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2017) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. 37th European Workshop for Rheumatology Research (EWRR 2017), Athens, Greece, 2-4 March 2017. (Unpublished)
2016
Alivernini, S. et al. (2016) MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis. Nature Communications, 7, 12970. (doi: 10.1038/ncomms12970) (PMID:27671860) (PMCID:PMC5052655)
Elmesmari, A., Alivernini, S., McInnes, I. B. and Kurowska-Stolarska, M. (2016) Targeting miR-155 in Rheumatoid Arthritis B Cells Reduces Antibody Production. Scottish Society of Rheumatology Meeting 2016, Dundee, 2016. (Unpublished)
2013
Tange, C. E., Alivernini, S., Gilchrist, D. S., Crawford, L., Rainey, A.-A., Baxter, D., McInnes, I. B. and Kurowska-Stolarska, M. (2013) Mir-34a in Rheumatoid Arthritis: characterisation of elevated synovial expression and association with treatment resistance. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S403.
2011
Kurowska-Stolarska, M. et al. (2011) MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proceedings of the National Academy of Sciences of the United States of America, 108(27), pp. 11193-11198. (doi: 10.1073/pnas.1019536108) (PMID:21690378)
Alivernini, S. et al. (2011) The role of microRNA-34 and microRNA-22 in dendritic cells and monocyte activation in rheumatoid arthritis. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Chicago, IL USA, 4-9 Nov 2011, S654.
Articles
Alivernini, S., Cañete, J. D., Bacardit, J. and Kurowska-Stolarska, M. (2024) Using explainable artificial intelligence to predict and forestall flare in rheumatoid arthritis. Nature Medicine, 30(4), pp. 925-926. (doi: 10.1038/s41591-024-02818-w) (PMID:38361121)
Coletto, L. A., Marino, V., Rizzo, C., Bruno, D., Caporali, R., Gremese, E., D'Agostino, M. A. and Alivernini, S. (2024) Intensive training programme for ultrasound-guided minimally invasive synovial tissue biopsy on knees and wrists in different phases of inflammation. RMD Open, 10(1), e003705. (doi: 10.1136/rmdopen-2023-003705) (PMID:38351051) (PMCID:PMC10868172)
Najm, A. et al. (2022) EULAR Points to consider for minimal reporting requirements in synovial tissue research in rheumatology. Annals of the Rheumatic Diseases, 81(12), pp. 1640-1646. (doi: 10.1136/annrheumdis-2021-221875) (PMID:35210263)
Kurowska-Stolarska, M. and Alivernini, S. (2022) Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission. Nature Reviews Rheumatology, 18, pp. 384-397. (doi: 10.1038/s41584-022-00790-8) (PMID:35672464)
Farina, L. et al. (2022) Pro nerve growth factor and its receptor p75NTR activate inflammatory responses in synovial fibroblasts: a novel targetable mechanism in arthritis. Frontiers in Immunology, 13, 818630. (doi: 10.3389/fimmu.2022.818630) (PMID:35309353) (PMCID:PMC8931659)
Clayton, S. A. et al. (2021) Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48. Science Advances, 7(50), eabl5182. (doi: 10.1126/sciadv.abl5182) (PMID:34878835)
MacDonald, L. et al. (2021) COVID-19 and RA share SPP1 myeloid pathway that drives PD-L1pos neutrophils and CD14pos monocytes. JCI Insight, 6(13), e147413. (doi: 10.1172/jci.insight.147413) (PMID:34143756) (PMCID:PMC8328085)
Wang, Y. et al. (2021) Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis. Nature Communications, 12, 2343. (doi: 10.1038/s41467-021-22365-z) (PMID:33879788) (PMCID:PMC8058094)
Alivernini, S. et al. (2020) Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nature Medicine, 26(8), pp. 1295-1306. (doi: 10.1038/s41591-020-0939-8) (PMID:32601335)
Alivernini, S., Tolusso, B., Ferraccioli, G., Gremese, E., Kurowska-Stolarska, M. and McInnes, I.B. (2018) Driving chronicity in rheumatoid arthritis: perpetuating role of myeloid cells. Clinical and Experimental Immunology, 193(1), pp. 13-23. (doi: 10.1111/cei.13098) (PMID:29315512) (PMCID:PMC6038003)
Alivernini, S., Gremese, E., McSharry, C., Tolusso, B., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2018) MicroRNA-155—at the critical interface of innate and adaptive immunity in arthritis. Frontiers in Immunology, 8, 1932. (doi: 10.3389/fimmu.2017.01932) (PMID:29354135) (PMCID:PMC5760508)
Kurowska-Stolarska, M. and Alivernini, S. (2017) Synovial tissue macrophages: friend or foe? RMD Open, 3(2), e000527. (doi: 10.1136/rmdopen-2017-000527) (PMID:29299338) (PMCID:PMC5729306)
Kurowska-Stolarska, M. et al. (2017) MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. Nature Communications, 8, 15877. (doi: 10.1038/ncomms15877) (PMID:28639625) (PMCID:PMC5489689)
Alivernini, S. et al. (2016) MicroRNA-155 influences B-cell function through PU.1 in rheumatoid arthritis. Nature Communications, 7, 12970. (doi: 10.1038/ncomms12970) (PMID:27671860) (PMCID:PMC5052655)
Kurowska-Stolarska, M. et al. (2011) MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proceedings of the National Academy of Sciences of the United States of America, 108(27), pp. 11193-11198. (doi: 10.1073/pnas.1019536108) (PMID:21690378)
Conference or Workshop Item
Finlay, S. et al. (2019) Presence of the MerTK Receptor on Human Synovial Tissue Macrophages Lowers Inflammatory Cytokine Production and Activation of the MerTK+CD206+ Subpopulation Limits the Inflammatory Response of Synovial Fibroblasts. 2019 ACR/ARP Annual Meeting, Atlanta, GA, USA, 08-13 Nov 2019.
Elmesmari, A. et al. (2019) Do Functional Interactions Between Macrophages and Synovial Fibroblasts Drive Synovial Pathology or Resolution of Inflammation? European League Against Rheumatism (EULAR) 2019 Congress, Madrid, Spain, 12-15 Jun 2019.
Finlay, S. et al. (2019) Single-cell Transcriptomic and Functional Analyses Reveal Novel Heterogeneity in Pathogenic Pathways Mediated by Human Synovial Tissue Macrophages. European League Against Rheumatism (EULAR) 2019 Congress, Madrid, Spain, 12-15 Jun 2019.
Alivernini, S. et al. (2018) Histological Features and Tissue-Macrophage Phenotype of Synovial Biopsies Identify RA Patients in Sustained Remission at Risk of Disease Flare after Treatment Tapering or Discontinuation. 2018 ACR/ARHP Annual Meeting, Chicago, IL, 19-24 Oct 2018. (Unpublished)
Elmesmari, A., Alivernini, S., Tolusso, B., Bui, L., Vaughan, D. , Federico, F., Gremese, E., McInnes, I. B. and Kurowska-Stolarska, M. (2018) Stolarska Synovial Tissue CD1c+ Dendritic Cells in Rheumatoid Arthritis Express High Levels of the Epigenetic Regulator of Inflammation, Microrna-155 and Inflammatory Cytokines. EULAR 2018: Annual European Congress of Rheumatology, Amsterdam, Netherlands, 13-16 June 2018. (Unpublished)
Finlay, S., Alivernini, S., Elmesmari, A., Tolusso, B., Ferraccioli, G., Gremese, E., Petricca, L., McInnes, I. B. , Kurowska-Stolarska, M. and Filer, A. (2018) Activation of Mertk+cd206+ Subpopulation of Human Synovial Tissue-Resident Macrophages Limits Inflammatory Response. EULAR 2018: Annual European Congress of Rheumatology, Amsterdam, Netherlands, 13-16 June 2018. (Unpublished)
Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. , Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2018) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. Microphage Biology in the Single-Cell Era, Ghent, Belgium, 2018. (Unpublished)
Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. , Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2017) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. EULAR 2017: Annual European Congress of Rheumatology, Madrid, Spain, 14-17 June 2017. (Unpublished)
Elmesmari, A., Alivernini, S., Vaughan, D. , Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2017) Characterisation of Synovium Tissues Macropahges. Rheumatology 2017, Birmingham, UK, 25-27 April 2017. (Unpublished)
Elmesmari, A., Alivernini, S., Tolusso, B., Vaughan, D. , Petricca, L., Gremese, E., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2017) Synovial Tissue of RA Patients in Remission Contains a Unique Population of Regulatory Macrophages. 37th European Workshop for Rheumatology Research (EWRR 2017), Athens, Greece, 2-4 March 2017. (Unpublished)
Elmesmari, A., Alivernini, S., McInnes, I. B. and Kurowska-Stolarska, M. (2016) Targeting miR-155 in Rheumatoid Arthritis B Cells Reduces Antibody Production. Scottish Society of Rheumatology Meeting 2016, Dundee, 2016. (Unpublished)
Conference Proceedings
Tange, C. E., Alivernini, S., Gilchrist, D. S., Crawford, L., Rainey, A.-A., Baxter, D., McInnes, I. B. and Kurowska-Stolarska, M. (2013) Mir-34a in Rheumatoid Arthritis: characterisation of elevated synovial expression and association with treatment resistance. In: 77th Annual Meeting of the American College of Rheumatology / 48th Annual Meeting of the Association of Rheumatology Health Professionals, San Diego, CA, 26-30 Oct 2013., S403.
Alivernini, S. et al. (2011) The role of microRNA-34 and microRNA-22 in dendritic cells and monocyte activation in rheumatoid arthritis. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Chicago, IL USA, 4-9 Nov 2011, S654.