Dr Charles McSharry

Honorary Clinical Senior Lecturer (School of Infection & Immunity)

email: Charles.McSharry@glasgow.ac.uk

Institute of III, Sir Graeme Davies Building, Level 4, 120 University Place, Glasgow, G12 8TA

Publications

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Number of items: 60.

2024

MacDonald, L. et al. (2024) Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis. Immunity, (doi: 10.1016/j.immuni.2024.11.004) (PMID:39609125) (Early Online Publication)

2022

Jackson, M. R. et al. (2022) Low-dose lung radiotherapy for COVID-19 lung disease: a preclinical efficacy study in a bleomycin model of pneumonitis. International Journal of Radiation Oncology, Biology, Physics, 112(1), pp. 197-211. (doi: 10.1016/j.ijrobp.2021.08.029) (PMID:34478832) (PMCID:PMC8406661)

2021

MacDonald, L. et al. (2021) COVID-19 and RA share SPP1 myeloid pathway that drives PD-L1pos neutrophils and CD14pos monocytes. JCI Insight, 6(13), e147413. (doi: 10.1172/jci.insight.147413) (PMID:34143756) (PMCID:PMC8328085)

2020

Ji, Y. et al. (2020) Krebs von den Lungen-6 (KL-6) is a pathophysiological biomarker of early-stage acute hypersensitivity pneumonitis among pigeon fanciers. Clinical and Experimental Allergy, 50(12), pp. 1391-1399. (doi: 10.1111/cea.13744) (PMID:32966647)

Henderson, I., Caiazzo, E., McSharry, C., Guzik, T. J. and Maffia, P. (2020) Why do some asthma patients respond poorly to glucocorticoid therapy? Pharmacological Research, 160, 105189. (doi: 10.1016/j.phrs.2020.105189) (PMID:32911071) (PMCID:PMC7672256)

Alivernini, S. et al. (2020) Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nature Medicine, 26(8), pp. 1295-1306. (doi: 10.1038/s41591-020-0939-8) (PMID:32601335)

Gurgone, D. , McShane, L. , McSharry, C., Guzik, T. J. and Maffia, P. (2020) Cytokines at the interplay between asthma and atherosclerosis? Frontiers in Pharmacology, 11, 166. (doi: 10.3389/fphar.2020.00166)

2018

Yang, J. F. et al. (2018) Insights into frequent asthma exacerbations from a primary care perspective and the implications of UK National Review of Asthma Deaths recommendations. npj Primary Care Respiratory Medicine, 28, 35. (doi: 10.1038/s41533-018-0103-9) (PMID:30232329) (PMCID:PMC6145932)

Alivernini, S., Gremese, E., McSharry, C., Tolusso, B., Ferraccioli, G., McInnes, I. B. and Kurowska-Stolarska, M. (2018) MicroRNA-155—at the critical interface of innate and adaptive immunity in arthritis. Frontiers in Immunology, 8, 1932. (doi: 10.3389/fimmu.2017.01932) (PMID:29354135) (PMCID:PMC5760508)

2017

Kurowska-Stolarska, M. et al. (2017) MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis. Nature Communications, 8, 15877. (doi: 10.1038/ncomms15877) (PMID:28639625) (PMCID:PMC5489689)

Kurowska-Stolarska, M. et al. (2017) The role of microRNA-155/LXR pathway in experimental and Idiopathic Pulmonary Fibrosis. Journal of Allergy and Clinical Immunology, 139(6), pp. 1946-1956. (doi: 10.1016/j.jaci.2016.09.021) (PMID:27746237) (PMCID:PMC5457127)

Skaaby, T. et al. (2017) Investigating the causal effect of smoking on hay fever and asthma: a Mendelian randomization meta-analysis in the CARTA consortium. Scientific Reports, 7, 2224. (doi: 10.1038/s41598-017-01977-w) (PMID:28533558) (PMCID:PMC5440386)

2016

Elmesmari, A., Fraser, A. R., Wood, C., Gilchrist, D., Vaughan, D. , Stewart, L., McSharry, C., McInnes, I. B. and Kurowska-Stolarska, M. (2016) MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis. Rheumatology, 55(11), pp. 2056-2065. (doi: 10.1093/rheumatology/kew272) (PMID:27411480) (PMCID:PMC5088623)

Chaudhuri, R. et al. (2016) Effects of older age and age of asthma onset on clinical and inflammatory variables in severe refractory asthma. Respiratory Medicine, 118, pp. 46-52. (doi: 10.1016/j.rmed.2016.07.005) (PMID:27578470)

Komai-Koma, M., Wang, E., Kurowska-Stolarska, M. , Li, D., McSharry, C. and Xu, D. (2016) Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12. Immunobiology, 221(3), pp. 412-417. (doi: 10.1016/j.imbio.2015.11.013) (PMID:26688508) (PMCID:PMC4731778)

McSharry, C. and Johnstone, S. (2016) Periostin as a biomarker of airway inflammation. Polish Archives of Internal Medicine, 126(3), pp. 118-120. (doi: 10.20452/pamw.3333) (PMID:27026095)

2015

Bicknell, S. et al. (2015) Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre. Therapeutic Advances in Respiratory Disease, 9(6), pp. 267-271. (doi: 10.1177/1753465815601332) (PMID:26307767)

Thomson, N. C., McSharry, C. and Chaudhuri, R. (2015) Response. CHEST Journal, 148(1), e33-e34. (doi: 10.1378/chest.15-0890) (PMID:26149566)

Thomson, N. C., Chaudhuri, R. , Spears, M., Haughney, J. and McSharry, C. (2015) Serum periostin in smokers and never smokers with asthma. Respiratory Medicine, 109(6), pp. 708-715. (doi: 10.1016/j.rmed.2015.03.009) (PMID:PMID:25869)

McSharry, C., Vesper, S., Wymer, L., Howieson, S., Chaudhuri, R. , Wright, G. R. and Thomson, N.C. (2015) Decreased FEV1% in asthmatic adults in Scottish homes with high environmental relative moldiness index values. Clinical and Experimental Allergy, 45(5), pp. 902-907. (doi: 10.1111/cea.12482) (PMID:25580663)

Thomson, N. C., Charron, C. E., Chaudhuri, R. , Spears, M., Ito, K. and McSharry, C. (2015) Atorvastatin in combination with inhaled beclometasone modulates inflammatory sputum mediators in smokers with asthma. Pulmonary Pharmacology and Therapeutics, 31, pp. 1-8. (doi: 10.1016/j.pupt.2015.01.001) (PMID:25595138)

Thomson, N. C., Chaudhuri, R. , Spears, M., Messow, C.-M. , MacNee, W., Connell, M., Murchison, J. T., Sproule, M. and McSharry, C. (2015) Poor symptom control is associated with reduced CT scan segmental airway lumen area in smokers with asthma. Chest, 147(3), p. 735. (doi: 10.1378/chest.14-1119) (PMID:25356950)

2014

Li, D. et al. (2014) IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice. Journal of Allergy and Clinical Immunology, 134(6), 1422-1432.e11. (doi: 10.1016/j.jaci.2014.05.011) (PMID:24985397) (PMCID:PMC4258609)

McSharry, C., Spears, M., Chaudhuri, R. , Cameron, E. J., Husi, H. and Thomson, N. C. (2014) Increased sputum endotoxin levels are associated with an impaired lung function response to oral steroids in asthmatic patients. Journal of Allergy and Clinical Immunology, 134(5), pp. 1068-1075. (doi: 10.1016/j.jaci.2014.08.022) (PMID:25262463)

Chaudhuri, R. et al. (2014) Low sputum MMP-9/TIMP ratio is associated with airway narrowing in smokers with asthma. European Respiratory Journal, 44(4), pp. 895-904. (doi: 10.1183/09031936.00047014)

Thomson, N.C. et al. (2014) Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking. Allergy, 69(4), pp. 527-536. (doi: 10.1111/all.12376)

2013

Cameron, E.J. et al. (2013) Randomised controlled trial of azithromycin in smokers with asthma. European Respiratory Journal, 42(5), pp. 1412-1415. (doi: 10.1183/09031936.00093913)

Thomson, N.C., Chaudhuri, R. , Messow, C.M. , Spears, M., MacNee, W., Connell, M., Murchison, J.T., Sproule, M. and McSharry, C. (2013) Chronic cough and sputum production are associated with worse clinical outcomes in stable asthma. Respiratory Medicine, 107(10), pp. 1501-1508. (doi: 10.1016/j.rmed.2013.07.017)

Bradley-Stewart, A., Jolly, L., Adamson, W., Gunson, R., Frew-Gillespie, C., Templeton, K., Aitken, C., Carman, W., Cameron, S. and McSharry, C. (2013) Cytokine responses in patients with mild or severe influenza A(H1N1)pdm09. Journal of Clinical Virology, 58(1), pp. 100-107. (doi: 10.1016/j.jcv.2013.05.011)

Pushparaj, P.N., Li, D., Komai-Koma, M., Guabiraba Brito, R., Alexander, J., McSharry, C. and Xu, D. (2013) Interleukin-33 exacerbates acute colitis via interleukin-4 in mice. Immunology, 140(1), pp. 70-77. (doi: 10.1111/imm.12111)

Thomson, N.C., Chaudhuri, R. , Heaney, L., Bucknall, C., Niven, R.M., Brightling, C.E., Menzies-Gow, A., Mansur, A.H. and McSharry, C. (2013) Clinical outcomes and inflammatory biomarkers in current smokers and exsmokers with severe asthma. Journal of Allergy and Clinical Immunology, 131(4), pp. 1008-1016. (doi: 10.1016/j.jaci.2012.12.1574)

Rzepecka, J., Siebeke, I., Coltherd, J.C., Kean, D.E., Steiger, C.N., Al-Riyami, L., McSharry, C., Harnett, M.M. and Harnett, W. (2013) The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype. International Journal for Parasitology, 43(3-4), pp. 211-223. (doi: 10.1016/j.ijpara.2012.12.001)

Qiu, C., Li, Y., Li, M., Li, M., Liu, X., McSharry, C. and Xu, D. (2013) Anti-interleukin-33 inhibits cigarette smoke-induced lung inflammation in mice. Immunology, 138(1), pp. 76-82. (doi: 10.1111/imm.12020)

Albarbarawi, O., Barton, A., Miller, D., McSharry, C., Chaudhuri, R. , Thomson, N. C., Palmer, C. N.A., Devereux, G. and Huang, J. T.-J. (2013) Characterization and validation of an isotope-dilution LC–MS/MS method for quantification of total desmosine and isodesmosine in plasma and serum. Bioanalysis, 5(16), pp. 1991-2001. (doi: 10.4155/BIO.13.164)

Spears, M., McSharry, C., Chaudhuri, R. , Weir, C.J., de Wet, C. and Thomson, N.C. (2013) Smoking in asthma is associated with elevated levels of corticosteroid resistant sputum cytokines—an exploratory study. PLoS ONE, 8(8), e71460. (doi: 10.1371/journal.pone.0071460) (PMID:23951170) (PMCID:PMC3739804)

2012

Komai-Koma, M. et al. (2012) Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice. Allergy, 67(9), pp. 1118-1126. (doi: 10.1111/j.1398-9995.2012.02859.x) (PMID:22702477) (PMCID:PMC3660789)

Shelley, B., McSharry, C., MacFie, A. and Kinsella, J. (2012) Biomarkers of acute lung injury after lung resection. Anaesthesia, 67(5), p. 554. (doi: 10.1111/j.1365-2044.2011.07052.x)

Huang, J.T.-J. et al. (2012) Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease. Thorax, 67(6), pp. 502-508. (doi: 10.1136/thoraxjnl-2011-200279)

Chaudhuri, R. et al. (2012) Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity. Journal of Allergy and Clinical Immunology, 129(3), 665-663.e8. (doi: 10.1016/j.jaci.2011.12.996)

Kurowska-Stolarska, M. , Hasoo, M., Gilchrist, D. G., Ruzicska, E., Asquith, D., Welsh, D., Crawford, L., Hirani, N., McInnes, I. B. and McSharry, C. (2012) Microrna-155 protects against pulmonary fibrosis by targeting the transcription regulator LXR alpha. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S386. (doi: 10.1002/art.37735)

Xuzhu, G., Komai-Koma, M., Leung, B.P., Howe, H.S., McSharry, C., McInnes, I.B. and Xu, D. (2012) Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function. Annals of the Rheumatic Diseases, 71(1), pp. 129-135. (doi: 10.1136/ard.2011.149831) (PMID:21953348)

2011

Kurowska-Stolarska, M. et al. (2011) MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proceedings of the National Academy of Sciences of the United States of America, 108(27), pp. 11193-11198. (doi: 10.1073/pnas.1019536108) (PMID:21690378)

Braganza, G. et al. (2011) Effects of short-term treatment with atorvastatin in smokers with asthma - a randomized controlled trial. BMC Pulmonary Medicine, 11(16), (doi: 10.1186/1471-2466-11-16)

Spears, M. et al. (2011) Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma. Clinical and Experimental Allergy, 41(5), pp. 665-672. (doi: 10.1111/j.1365-2222.2010.03692.x)

Spears, M., Weir, C.J., Smith, A.D., McSharry, C., Chaudhuri, R., Johnson, M., Cameron, E. and Thomson, N.C. (2011) Bronchial nitric oxide flux (J′aw) is sensitive to oral corticosteroids in smokers with asthma. Respiratory Medicine, 105(12), pp. 1823-1830. (doi: 10.1016/j.rmed.2011.06.014)

2010

Sandilands, G. P., Wilson, M., Huser, C. , Jolly, L., Sands, W. A. and McSharry, C. (2010) Were monocytes responsible for initiating the cytokine storm in the TGN1412 clinical trial tragedy? Clinical and Experimental Immunology, 162(3), pp. 516-527. (doi: 10.1111/j.1365-2249.2010.04264.x)

2009

Wright, G.R. et al. (2009) Effect of improved home ventilation on asthma control and house dust mite allergen levels. Allergy, 64(11), pp. 1671-1680. (doi: 10.1111/j.1398-9995.2009.02098.x)

Kurowska-Stolarska, M. et al. (2009) IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation. Journal of Immunology, 183(10), pp. 6469-6477. (doi: 10.4049/jimmunol.0901575) (PMID:19841166)

Murphy, C., Blyth, K., Chaudhuri, R., Lafferty, J., Hothersall, E., Steedman, T., McSharry, C., Dargie, H. and Thomson, N. (2009) Assessment of the Presence of Occult Myocardial Infarction in Chronic Obstructive Pulmonary Disease Using Contrast-Enhanced Cardiac Magnetic Resonance Imaging. Respiration, 78(3), pp. 263-269.

Murphy, G.E.J., Pitman, N.I., Kurowska-Stolarska, M. , Kewin, P., Xu, D., McSharry, C., Thomson, N.C. and Shepherd, M.C. (2009) Murine airway eosinophilia following IL-33 administration is eotaxin dependent. In: American Thoracic Society 2009 International Conference, San Diego, CA, USA, 15-20 May 2009, A4253. (doi: 10.1164/ajrccm-conference.2009.179.1_MeetingAbstracts.A4253)

Spears, M. et al. (2009) Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study. European Respiratory Journal, 33(5), pp. 1010-1017. (doi: 10.1183/09031936.00158208)

Spears, M. et al. (2009) Bronchodilatory Effect of the PPAR-gamma Agonist Rosiglitazone in Smokers With Asthma. Clinical Pharmacology and Therapeutics, 86(1), pp. 49-53. (doi: 10.1038/clpt.2009.41)

2008

Chaudhuri, R., McSharry, C., McCoard, A., Livingston, E., Hothersall, E., Spears, M., Lafferty, J. and Thomson, N. (2008) Role of symptoms and lung function in determining asthma control in smokers with asthma. Allergy, 63(1), pp. 132-135.

Hothersall, E. et al. (2008) Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma. Thorax, 63(12), pp. 1070-1075. (doi: 10.1136/thx.2008.100198)

2006

Chaudhuri, R., Livingston, E., McMahon, A. D., Lafferty, J., Fraser, I., Spears, M., McSharry, C. P. and Thomson, N. C. (2006) Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. American Journal of Respiratory and Critical Care Medicine, 174(2), pp. 127-133. (doi: 10.1164/rccm.200510-1589OC)

Aguila, A., Donachie, A. M., Peyre, M., McSharry, C. P., Sesardic, D. and Mowat, A. M. (2006) Induction of protective and mucosal immunity against diphtheria by a immune stimulating complex (ISCOMS) based vaccine. Vaccine, 24, pp. 5201-5210. (doi: 10.1016/j.vaccine.2006.03.081) (PMID:16650917)

Spears, M., McSharry, C. and Thomson, N.C. (2006) Peroxisome proliferator-activated receptor-7 agonists as potential anti-inflammatory agents in asthma and chronic obstructive pulmonary disease. Clinical and Experimental Allergy, 36, pp. 1494-1504.

2002

Little, S. A., MacLeod, K. J., Chalmers, G. W., Love, J. G., McSharry, C. and Thomson, N. C. (2002) Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma. American Journal of Medicine, 112(6), pp. 446-452. (doi: 10.1016/S0002-9343(02)01047-1)

Little, S.A., Sproule, M.W., Cowan, M.D., Macleod, K.J., Robertson, M., Love, J.G., Chalmers, G.W., McSharry, C. and Thomson, N. (2002) High resolution computed tomography assessment of airway wall thickness in chronic asthma: reproducibility and relationship with lung function and severity. Thorax, 57(3), pp. 247-253. (doi: 10.1136/thorax.57.3.247)

2000

Taylor, M.A., Reilly, D., Llewellyn-Jones, R.H., McSharry, C. and Aitchison, T., (2000) Randomised controlled trial of homoeopathy versus placebo in perennial allergic rhinitis with overview of four trial series. British Medical Journal, 321, pp. 471-476. (doi: 10.1136/bmj.321.7259.471)

This list was generated on Wed Dec 18 22:21:51 2024 GMT.

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