Mr Edward Dornan
- Technician (Virology)
telephone:
01413305610
email:
Edward.Dornan@glasgow.ac.uk
4th Floor HWB, Garscube, Glasgow G61 1QH
Research interests
Member of the Elliott Group.
Publications
2015
Gauson, E. J., Donaldson, M. , Dornan, E. S., Wang, X., Bristol, M., Bodily, J. M. and Morgan, I. M. (2015) Evidence supporting a role for TopBP1 and Brd4 in the initiation but not continuation of human papillomavirus 16 E1/E2-mediated DNA replication. Journal of Virology, 89(9), pp. 4980-4991. (doi: 10.1128/JVI.00335-15) (PMID:25694599) (PMCID:PMC4403487)
2014
Gauson, E. J., Windle, B., Donaldson, M. , Cafarel, M. M., Dornan, E., Coleman, N., Herzyk, P. , Henderson, S. C., Wang, X. and Morgan, I. (2014) Regulation of human genome expression and RNA splicing by human papillomavirus 16 E2 protein. Virology, 468-70, pp. 10-18. (doi: 10.1016/j.virol.2014.07.022)
2012
Donaldson, M.M. , Mackintosh, L.J., Bodily, J.M., Dornan, E.S., Laimins, L.A. and Morgan, I.M. (2012) An interaction between human papillomavirus 16 E2 and TopBP1is required for optimum viral DNA replication and episomal genome establishment. Journal of Virology, 86(23), pp. 12806-12815. (doi: 10.1128/JVI.01002-12)
2011
King, L.E., Dornan, E.S., Donaldson, M.M. and Morgan, I.M. (2011) Human papillomavirus 16 E2 stability and transcriptional activation is enhanced by E1 via a direct protein–protein interaction. Virology, 414(1), pp. 26-33. (doi: 10.1016/j.virol.2011.03.002)
2010
King, L.E., Fisk, J.C., Dornan, E.S., Donaldson, M.M. , Melendy, T. and Morgan, I.M. (2010) Human papillomavirus E1 and E2 mediated DNA replication is not arrested by DNA damage signalling. Virology, 406(1), pp. 95-102. (doi: 10.1016/j.virol.2010.06.033)
Campo, M.S., Graham, S.V. , Cortese, M.S., Ashrafi, G.H., Araibi, E.H., Dornan, E.S., Miners, K., Nunes, C. and Man, S. (2010) HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells. Virology, 407(1), pp. 137-142. (doi: 10.1016/j.virol.2010.07.044)
2009
Johansson, C., Graham, S.V. , Dornan, E.S. and Morgan, I.M. (2009) The human papillomavirus 16 E2 protein is stabilised in S phase. Virology, 394(2), pp. 194-199. (doi: 10.1016/j.virol.2009.08.046) (PMID:19781729)
2008
Wright, R.H.G., Dornan, E.S., Donaldson, M.M. , MacFarlane, M., Herzyk, P. and Morgan, I.M. (2008) TopBP1 contains transcriptional regulatory domains and regulates gene pathways involved in breast cancer. In: Breast Cancer Research 2008, London, UK, 13 May 2008, P21. (doi: 10.1186/bcr 1905)
2007
Going, J.J., Nixon, C., Dornan, E.S., Boner, W. , Donaldson, M.M. and Morgan, I.M. (2007) Aberrant expression of TopBP1 in breast cancer. Histopathology, 50(4), pp. 418-424. (doi: 10.1111/j.1365-2559.2007.02622.x)
2006
Araibi, E.H., Marchetti, B., Dornan, E.S., Ashrafi, G.H., Dobromylskyj, D., Ellis, S.A. and Campo, M.S. (2006) The E5 oncoprotein of BPV-4 does not interfere with the biosynthetic pathway of non-classical MHC class I. Virology, 353(1), pp. 174-183. (doi: 10.1016/j.virol.2006.05.031)
Marchetti, B., Ashrafi, G.H., Dornan, E.S., Araibi, E.H., Ellis, S.A. and Campo, M.S. (2006) The E5 protein of BPV-4 interacts with the heavy chain of MHC class I and irreversibly retains the MHC complex in the Golgi apparatus. Oncogene, 25(15), pp. 2254-2263. (doi: 10.1038/sj.onc.1209245)
Wright, R.H.G., Dornan, E.S., Donaldson, M.M. and Morgan, I.M. (2006) TopBP1 contains a transcriptional activation domain suppressed by two adjacent BRCT domains. Biochemical Journal, 400, pp. 573-582. (doi: 10.1042/BJ20060831)
2004
Torre, F., Cramp, M., Owsianka, A., Dornan, E.., Marsden, H., Carman, W., Williams, R. and Naoumov, N.V. (2004) Direct evidence that naturally occurring mutations within hepatitis B core epitope alter CD4+T-Cell reactivity. Journal of Medical Virology, 72, pp. 370-376. (doi: 10.1002/jmv.20016)
2003
Taylor, E. R., Boner, W. , Dornan, E. S., Corr, E. M. and Morgan, I. M. (2003) UVB irradiation reduces the half-life and transactivation potential of the human papillomavirus 16 E2 protein. Oncogene, 22, pp. 4469-4477. (doi: 10.1038/sj.onc.1206746) (PMID:12881703)
Taylor, E. R., Dornan, E. S., Boner, W. , Connolly, J. A., McNair, S., Kannouche, P., Lehmann, A.R. and Morgan, I. M. (2003) The fidelity of HPV16 E1/E2-mediated DNA replication. Journal of Biological Chemistry, 278, pp. 52223-52230. (doi: 10.1074/jbc.M308779200) (PMID:14559922)
Articles
Gauson, E. J., Donaldson, M. , Dornan, E. S., Wang, X., Bristol, M., Bodily, J. M. and Morgan, I. M. (2015) Evidence supporting a role for TopBP1 and Brd4 in the initiation but not continuation of human papillomavirus 16 E1/E2-mediated DNA replication. Journal of Virology, 89(9), pp. 4980-4991. (doi: 10.1128/JVI.00335-15) (PMID:25694599) (PMCID:PMC4403487)
Gauson, E. J., Windle, B., Donaldson, M. , Cafarel, M. M., Dornan, E., Coleman, N., Herzyk, P. , Henderson, S. C., Wang, X. and Morgan, I. (2014) Regulation of human genome expression and RNA splicing by human papillomavirus 16 E2 protein. Virology, 468-70, pp. 10-18. (doi: 10.1016/j.virol.2014.07.022)
Donaldson, M.M. , Mackintosh, L.J., Bodily, J.M., Dornan, E.S., Laimins, L.A. and Morgan, I.M. (2012) An interaction between human papillomavirus 16 E2 and TopBP1is required for optimum viral DNA replication and episomal genome establishment. Journal of Virology, 86(23), pp. 12806-12815. (doi: 10.1128/JVI.01002-12)
King, L.E., Dornan, E.S., Donaldson, M.M. and Morgan, I.M. (2011) Human papillomavirus 16 E2 stability and transcriptional activation is enhanced by E1 via a direct protein–protein interaction. Virology, 414(1), pp. 26-33. (doi: 10.1016/j.virol.2011.03.002)
King, L.E., Fisk, J.C., Dornan, E.S., Donaldson, M.M. , Melendy, T. and Morgan, I.M. (2010) Human papillomavirus E1 and E2 mediated DNA replication is not arrested by DNA damage signalling. Virology, 406(1), pp. 95-102. (doi: 10.1016/j.virol.2010.06.033)
Campo, M.S., Graham, S.V. , Cortese, M.S., Ashrafi, G.H., Araibi, E.H., Dornan, E.S., Miners, K., Nunes, C. and Man, S. (2010) HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells. Virology, 407(1), pp. 137-142. (doi: 10.1016/j.virol.2010.07.044)
Johansson, C., Graham, S.V. , Dornan, E.S. and Morgan, I.M. (2009) The human papillomavirus 16 E2 protein is stabilised in S phase. Virology, 394(2), pp. 194-199. (doi: 10.1016/j.virol.2009.08.046) (PMID:19781729)
Going, J.J., Nixon, C., Dornan, E.S., Boner, W. , Donaldson, M.M. and Morgan, I.M. (2007) Aberrant expression of TopBP1 in breast cancer. Histopathology, 50(4), pp. 418-424. (doi: 10.1111/j.1365-2559.2007.02622.x)
Araibi, E.H., Marchetti, B., Dornan, E.S., Ashrafi, G.H., Dobromylskyj, D., Ellis, S.A. and Campo, M.S. (2006) The E5 oncoprotein of BPV-4 does not interfere with the biosynthetic pathway of non-classical MHC class I. Virology, 353(1), pp. 174-183. (doi: 10.1016/j.virol.2006.05.031)
Marchetti, B., Ashrafi, G.H., Dornan, E.S., Araibi, E.H., Ellis, S.A. and Campo, M.S. (2006) The E5 protein of BPV-4 interacts with the heavy chain of MHC class I and irreversibly retains the MHC complex in the Golgi apparatus. Oncogene, 25(15), pp. 2254-2263. (doi: 10.1038/sj.onc.1209245)
Wright, R.H.G., Dornan, E.S., Donaldson, M.M. and Morgan, I.M. (2006) TopBP1 contains a transcriptional activation domain suppressed by two adjacent BRCT domains. Biochemical Journal, 400, pp. 573-582. (doi: 10.1042/BJ20060831)
Torre, F., Cramp, M., Owsianka, A., Dornan, E.., Marsden, H., Carman, W., Williams, R. and Naoumov, N.V. (2004) Direct evidence that naturally occurring mutations within hepatitis B core epitope alter CD4+T-Cell reactivity. Journal of Medical Virology, 72, pp. 370-376. (doi: 10.1002/jmv.20016)
Taylor, E. R., Boner, W. , Dornan, E. S., Corr, E. M. and Morgan, I. M. (2003) UVB irradiation reduces the half-life and transactivation potential of the human papillomavirus 16 E2 protein. Oncogene, 22, pp. 4469-4477. (doi: 10.1038/sj.onc.1206746) (PMID:12881703)
Taylor, E. R., Dornan, E. S., Boner, W. , Connolly, J. A., McNair, S., Kannouche, P., Lehmann, A.R. and Morgan, I. M. (2003) The fidelity of HPV16 E1/E2-mediated DNA replication. Journal of Biological Chemistry, 278, pp. 52223-52230. (doi: 10.1074/jbc.M308779200) (PMID:14559922)
Conference Proceedings
Wright, R.H.G., Dornan, E.S., Donaldson, M.M. , MacFarlane, M., Herzyk, P. and Morgan, I.M. (2008) TopBP1 contains transcriptional regulatory domains and regulates gene pathways involved in breast cancer. In: Breast Cancer Research 2008, London, UK, 13 May 2008, P21. (doi: 10.1186/bcr 1905)
