Professor Daniel Wall

  • Professor (Bacteriology)

telephone: 01413307123
email: Donal.Wall@glasgow.ac.uk
pronouns: He/him/his

RB225 Level B2, Iii - Gbrc, University Place, Glasgow G12 8TA

Import to contacts

ORCID iDhttps://orcid.org/0000-0002-0421-1951

Biography

I carried out my PhD in Professor Wim Meijer’s laboratory at University College Dublin, Ireland studying the intracellular survival mechanisms of the opportunistic pathogen Rhodococcus equi.

Following this I moved to Boston where I carried out my first postdoctoral fellowship in Professor Beth McCormick’s laboratory at Harvard Medical School/Massachusetts General Hospital. While there I looked at the mucosal immunology of Salmonella Typhimurium infection, in particular with regard to intestinal inflammation involving migrating neutrophils.

A second postdoctoral position in Professor Peter Ghazal’s Division of Pathway Medicine at the University of Edinburgh involved studying the host pathways involved in the immune response to herpes virus infections, in particular how cytomegalovirus reactivates from latency in response to stimuli from the host.

I then moved to the University of Glasgow to take up my present position as a Principal Investigator and Lecturer. I have combined my diverse research experience to focus on the host response to microbial infection with a particular interest in how bacteria interact with Programmed Cell Death (PCD) pathways.

Visit the Wall Lab webpage

Research interests

Bacterial pathogens can cause either acute or persistent infections. Their capacity to cause these distinct types of diseases depends on their ability to influence or control the environment they find themselves in once they infect a host organism.

Within intestinal epithelial cells or circulating immune cells some bacterial pathogens can establish a niche for survival and replication. Despite attempts by host cells these pathogens survive by undermining host pathways that normally remove and respond to intracellular microbes.

As a last resort host cells induce cell suicide, removing themselves and the perceived threat from the body. Some bacterial pathogens we now know can also disrupt this process, keeping infected cells alive for prolonged periods facilitating replication of the bacteria intracellularly.

The consequences for the host organism can be profound with persistent periods of inflammation, especially when immune cells such as macrophages and dendritic cells are involved.


Visit the Wall Lab webpage

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2017 | 2016 | 2015 | 2014 | 2013 | 2010
Number of items: 24.

2024

Adams, L., Li, X., Burchmore, R. , Goodwin, R. and Wall, D. M. (2024) Microbiome-derived metabolite effects on intestinal barriercell response to infection. Microbiology, 170(10), 001504. (doi: 10.1099/mic.0.001504) (PMID:39392674)

Li, X., Cole, J., Vaughan, D. , Xiao, Y., Walker, D. and Wall, D. M. (2024) Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohn’s disease associated adherent-invasive Escherichia coli infection. Microbiology, 170(6), 001470. (doi: 10.1099/mic.0.001470) (PMID:38916198)

2023

Li, X., Ormsby, M. J. , Fallata, G., Meikle, L. M., Walker, D. , Xu, D. and Wall, D. M. (2023) PF-431396 hydrate inhibition of kinase phosphorylation during adherent-invasive Escherichia coli infection inhibits intra-macrophage replication and inflammatory cytokine release. Microbiology, 169(6), 001337. (doi: 10.1099/mic.0.001337) (PMID:37311220) (PMCID:PMC10333790)

2022

Hulme, H. et al. (2022) Mapping the influence of the gut microbiota on small molecules across the microbiome gut brain axis. Journal of the American Society for Mass Spectrometry, 33(4), pp. 649-659. (doi: 10.1021/jasms.1c00298) (PMID:35262356) (PMCID:PMC9047441)

2021

Johnson, S. A. et al. (2021) Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model. European Journal of Immunology, 51(12), pp. 3228-3238. (doi: 10.1002/eji.202048913) (PMID:34633664) (PMCID:PMC9214623)

Kästele, V. et al. (2021) Intestinal-derived ILCs migrating in lymph increase IFNγ production in response to Salmonella Typhimurium infection. Mucosal Immunology, 14(3), pp. 717-727. (doi: 10.1038/s41385-020-00366-3) (PMID:33414524) (PMCID:PMC8075955)

2020

Clay, S. L. , Bravo-Blas, A., Wall, D. M. , MacLeod, M. K.L. and Milling, S. W.F. (2020) Regulatory T cells control the dynamic and site-specific polarization of total CD4 T cells following Salmonella infection. Mucosal Immunology, 13(6), pp. 946-957. (doi: 10.1038/s41385-020-0299-1) (PMID:32457450) (PMCID:PMC7567643)

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

Ormsby, M. et al. (2020) Propionic acid promotes the virulent phenotype of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. (doi: 10.1016/j.celrep.2020.01.078) (PMID:32075765) (PMCID:PMC7034058)

2019

Johnson, S. A., Ormsby, M. J. , McIntosh, A., Tait, S. W.G. , Blyth, K. and Wall, D. M. (2019) Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori. Cancer Gene Therapy, 26(7-8), pp. 183-194. (doi: 10.1038/s41417-018-0039-9) (PMID:30100607) (PMCID:PMC6760541)

Ormsby, M. J. et al. (2019) Inflammation associated ethanolamine facilitates infection by Crohn's disease-linked adherent-invasive Escherichia coli. EBioMedicine, 43, pp. 325-332. (doi: 10.1016/j.ebiom.2019.03.071) (PMID:31036531) (PMCID:PMC6557746)

Bravo-Blas, A. A., Utriainen, L., Clay, S. , Kästele, V., Cerovic, V., Cunningham, A. C., Henderson, I. R., Wall, D. and Milling, S. W.F. (2019) Salmonella enterica serovar Typhimurium travels to mesenteric lymph nodes both with host cells, and autonomously. Journal of Immunology, 202(1), pp. 260-267. (doi: 10.4049/jimmunol.1701254) (PMID:30487173) (PMCID:PMC6305795)

Patel, S., Wall, D. M. , Castillo, A. and McCormick, B. A. (2019) Caspase-3 cleavage of Salmonella type III secreted effector protein SifA is required for localization of functional domains and bacterial dissemination. Gut Microbes, 10(2), pp. 172-187. (doi: 10.1080/19490976.2018.1506668) (PMID:30727836) (PMCID:PMC6546311)

2017

McIntosh, A., Meikle, L. M., Ormsby, M. J. , McCormick, B. A., Christie, J. M. , Brewer, J. M. , Roberts, M. and Wall, D. M. (2017) SipA activation of caspase-3 is a decisive mediator of host cell survival at early stages of Salmonella enterica serovar typhimurium Infection. Infection and Immunity, 85(9), e00393-17. (doi: 10.1128/IAI.00393-17) (PMID:28630067) (PMCID:PMC5563584)

HULME, H. E. et al. (2017) Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection. Scientific Reports, 7, 2786. (doi: 10.1038/s41598-017-03100-5) (PMID:28584281) (PMCID:PMC5459799)

Johnson, S. A., Ormsby, M. J. and Wall, D. (2017) Draft genome sequence of the tumor-targeting salmonella enterica serovar typhimurium strain SL7207. Genome Announcements, 5(5), e01591-16. (doi: 10.1128/genomeA.01591-16) (PMID:28153911) (PMCID:PMC5289697)

2016

Ormsby, M. J. , Johnson, S. A. and Wall, D. M. (2016) Draft genome sequence of the commensal Escherichia coli strain F-18. Genome Announcements, 4(6), e01416-16. (doi: 10.1128/genomeA.01416-16) (PMID:28007857) (PMCID:PMC5180385)

Kinning, E., McMillan, M., Shepherd, S., Helfrich, M., vant Hof, R., Adams, C., Read, H., Wall, D. M. and Ahmed, S. F. (2016) An unbalanced rearrangement of chromosomes 4:20 is associated with childhood osteoporosis and reduced caspase-3 levels. Journal of Pediatric Genetics, 5(3), pp. 167-173. (doi: 10.1055/s-0036-1584359) (PMID:27617159)

2015

Brown, C. L., Smith, K., Wall, D. and Walker, D. (2015) Activity of species-specific antibiotics against Crohnʼs disease–associated adherent-invasive Escherichia coli. Inflammatory Bowel Diseases, 21(10), pp. 2372-2382. (doi: 10.1097/MIB.0000000000000488) (PMID:26177305)

Fyfe, C.D., Grinter, R., Josts, I., Mosbahi, K., Roszak, A.W., Cogdell, R.J. , Wall, D.M. , Burchmore, R.J.S. , Byron, O. and Walker, D. (2015) Structure of protease-cleaved escherichia coliα-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment. Acta Crystallographica. Section D: Biological Crystallography, 71(7), pp. 1478-1486. (doi: 10.1107/s1399004715008548) (PMID:26143919) (PMCID:PMC4498604)

2014

Wall, D. M. and McCormick, B. A. (2014) Bacterial secreted effectors and caspase-3 interactions. Cellular Microbiology, 16(12), pp. 1746-1756. (doi: 10.1111/cmi.12368) (PMID:25262664) (PMCID:PMC4257569)

2013

Dunne, K.A. et al. (2013) Increased S-nitrosylation and proteasomal degradation of caspase-3 during infection contribute to the persistence of adherent invasive escherichia coli (AIEC) in immune cells. PLoS ONE, 8(7), e68386. (doi: 10.1371/journal.pone.0068386) (PMID:23861899) (PMCID:PMC3701656)

2010

Srikanth, C.V., Wall, D.M. , Maldonado-Contreras, A., Shi, H.N., Zhou, D.G., Demma, Z., Mumy, K.L. and Mccormick, B.A. (2010) Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3. Science, 330(6002), pp. 390-393. (doi: 10.1126/science.1194598)

Wall, D.M. , Srikanth, C.V. and McCormick, B.A. (2010) Targeting tumors with Salmonella Typhimurium - potential for therapy. Oncotarget, 1(8), pp. 721-728.

This list was generated on Wed Dec 18 20:09:36 2024 GMT.
Jump to: Articles
Number of items: 24.

Articles

Adams, L., Li, X., Burchmore, R. , Goodwin, R. and Wall, D. M. (2024) Microbiome-derived metabolite effects on intestinal barriercell response to infection. Microbiology, 170(10), 001504. (doi: 10.1099/mic.0.001504) (PMID:39392674)

Li, X., Cole, J., Vaughan, D. , Xiao, Y., Walker, D. and Wall, D. M. (2024) Stratifying macrophages based on their infectious burden identifies novel host targets for intervention during Crohn’s disease associated adherent-invasive Escherichia coli infection. Microbiology, 170(6), 001470. (doi: 10.1099/mic.0.001470) (PMID:38916198)

Li, X., Ormsby, M. J. , Fallata, G., Meikle, L. M., Walker, D. , Xu, D. and Wall, D. M. (2023) PF-431396 hydrate inhibition of kinase phosphorylation during adherent-invasive Escherichia coli infection inhibits intra-macrophage replication and inflammatory cytokine release. Microbiology, 169(6), 001337. (doi: 10.1099/mic.0.001337) (PMID:37311220) (PMCID:PMC10333790)

Hulme, H. et al. (2022) Mapping the influence of the gut microbiota on small molecules across the microbiome gut brain axis. Journal of the American Society for Mass Spectrometry, 33(4), pp. 649-659. (doi: 10.1021/jasms.1c00298) (PMID:35262356) (PMCID:PMC9047441)

Johnson, S. A. et al. (2021) Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model. European Journal of Immunology, 51(12), pp. 3228-3238. (doi: 10.1002/eji.202048913) (PMID:34633664) (PMCID:PMC9214623)

Kästele, V. et al. (2021) Intestinal-derived ILCs migrating in lymph increase IFNγ production in response to Salmonella Typhimurium infection. Mucosal Immunology, 14(3), pp. 717-727. (doi: 10.1038/s41385-020-00366-3) (PMID:33414524) (PMCID:PMC8075955)

Clay, S. L. , Bravo-Blas, A., Wall, D. M. , MacLeod, M. K.L. and Milling, S. W.F. (2020) Regulatory T cells control the dynamic and site-specific polarization of total CD4 T cells following Salmonella infection. Mucosal Immunology, 13(6), pp. 946-957. (doi: 10.1038/s41385-020-0299-1) (PMID:32457450) (PMCID:PMC7567643)

Hulme, H. et al. (2020) Microbiome-derived carnitine mimics as novel mediators of gut-brain axis communication. Science Advances, 6(11), eaax6328. (doi: 10.1126/sciadv.aax6328) (PMID:32195337) (PMCID:PMC7065903)

Ormsby, M. et al. (2020) Propionic acid promotes the virulent phenotype of Crohn's disease-associated adherent-invasive Escherichia coli. Cell Reports, 30(7), 2297-2305.e5. (doi: 10.1016/j.celrep.2020.01.078) (PMID:32075765) (PMCID:PMC7034058)

Johnson, S. A., Ormsby, M. J. , McIntosh, A., Tait, S. W.G. , Blyth, K. and Wall, D. M. (2019) Increasing the bactofection capacity of a mammalian expression vector by removal of the f1 ori. Cancer Gene Therapy, 26(7-8), pp. 183-194. (doi: 10.1038/s41417-018-0039-9) (PMID:30100607) (PMCID:PMC6760541)

Ormsby, M. J. et al. (2019) Inflammation associated ethanolamine facilitates infection by Crohn's disease-linked adherent-invasive Escherichia coli. EBioMedicine, 43, pp. 325-332. (doi: 10.1016/j.ebiom.2019.03.071) (PMID:31036531) (PMCID:PMC6557746)

Bravo-Blas, A. A., Utriainen, L., Clay, S. , Kästele, V., Cerovic, V., Cunningham, A. C., Henderson, I. R., Wall, D. and Milling, S. W.F. (2019) Salmonella enterica serovar Typhimurium travels to mesenteric lymph nodes both with host cells, and autonomously. Journal of Immunology, 202(1), pp. 260-267. (doi: 10.4049/jimmunol.1701254) (PMID:30487173) (PMCID:PMC6305795)

Patel, S., Wall, D. M. , Castillo, A. and McCormick, B. A. (2019) Caspase-3 cleavage of Salmonella type III secreted effector protein SifA is required for localization of functional domains and bacterial dissemination. Gut Microbes, 10(2), pp. 172-187. (doi: 10.1080/19490976.2018.1506668) (PMID:30727836) (PMCID:PMC6546311)

McIntosh, A., Meikle, L. M., Ormsby, M. J. , McCormick, B. A., Christie, J. M. , Brewer, J. M. , Roberts, M. and Wall, D. M. (2017) SipA activation of caspase-3 is a decisive mediator of host cell survival at early stages of Salmonella enterica serovar typhimurium Infection. Infection and Immunity, 85(9), e00393-17. (doi: 10.1128/IAI.00393-17) (PMID:28630067) (PMCID:PMC5563584)

HULME, H. E. et al. (2017) Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection. Scientific Reports, 7, 2786. (doi: 10.1038/s41598-017-03100-5) (PMID:28584281) (PMCID:PMC5459799)

Johnson, S. A., Ormsby, M. J. and Wall, D. (2017) Draft genome sequence of the tumor-targeting salmonella enterica serovar typhimurium strain SL7207. Genome Announcements, 5(5), e01591-16. (doi: 10.1128/genomeA.01591-16) (PMID:28153911) (PMCID:PMC5289697)

Ormsby, M. J. , Johnson, S. A. and Wall, D. M. (2016) Draft genome sequence of the commensal Escherichia coli strain F-18. Genome Announcements, 4(6), e01416-16. (doi: 10.1128/genomeA.01416-16) (PMID:28007857) (PMCID:PMC5180385)

Kinning, E., McMillan, M., Shepherd, S., Helfrich, M., vant Hof, R., Adams, C., Read, H., Wall, D. M. and Ahmed, S. F. (2016) An unbalanced rearrangement of chromosomes 4:20 is associated with childhood osteoporosis and reduced caspase-3 levels. Journal of Pediatric Genetics, 5(3), pp. 167-173. (doi: 10.1055/s-0036-1584359) (PMID:27617159)

Brown, C. L., Smith, K., Wall, D. and Walker, D. (2015) Activity of species-specific antibiotics against Crohnʼs disease–associated adherent-invasive Escherichia coli. Inflammatory Bowel Diseases, 21(10), pp. 2372-2382. (doi: 10.1097/MIB.0000000000000488) (PMID:26177305)

Fyfe, C.D., Grinter, R., Josts, I., Mosbahi, K., Roszak, A.W., Cogdell, R.J. , Wall, D.M. , Burchmore, R.J.S. , Byron, O. and Walker, D. (2015) Structure of protease-cleaved escherichia coliα-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment. Acta Crystallographica. Section D: Biological Crystallography, 71(7), pp. 1478-1486. (doi: 10.1107/s1399004715008548) (PMID:26143919) (PMCID:PMC4498604)

Wall, D. M. and McCormick, B. A. (2014) Bacterial secreted effectors and caspase-3 interactions. Cellular Microbiology, 16(12), pp. 1746-1756. (doi: 10.1111/cmi.12368) (PMID:25262664) (PMCID:PMC4257569)

Dunne, K.A. et al. (2013) Increased S-nitrosylation and proteasomal degradation of caspase-3 during infection contribute to the persistence of adherent invasive escherichia coli (AIEC) in immune cells. PLoS ONE, 8(7), e68386. (doi: 10.1371/journal.pone.0068386) (PMID:23861899) (PMCID:PMC3701656)

Srikanth, C.V., Wall, D.M. , Maldonado-Contreras, A., Shi, H.N., Zhou, D.G., Demma, Z., Mumy, K.L. and Mccormick, B.A. (2010) Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3. Science, 330(6002), pp. 390-393. (doi: 10.1126/science.1194598)

Wall, D.M. , Srikanth, C.V. and McCormick, B.A. (2010) Targeting tumors with Salmonella Typhimurium - potential for therapy. Oncotarget, 1(8), pp. 721-728.

This list was generated on Wed Dec 18 20:09:36 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Investigating the role of Enterocloster clostridioformis bacteriophages in gut microbiome dysbiosis associated with metabolic disease states.
    Tenovus Scotland
    2024 - 2025
     
  • Glasgow University Microbiome Initiative (GUMI) symposium
    Medical Research Council
    2022 - 2022
     
  • Systemic spread of gut bacterial metabolites and the role in host health
    Biotechnology and Biological Sciences Research Council
    2021 - 2024
     
  • Molecular mechanisms enabling DCs to control CD4 T cell priming.
    Medical Research Council
    2020 - 2023
     
  • Elucidating the role of bacterial microcompartments in the pathogenesis of Crohns disease associated adherent-invasive Escherichia coli
    Tenovus Scotland
    2018 - 2019
     
  • Propionic acid use in agriculture and food production is driving evolution of novel Escherichia coli pathotypes
    Biotechnology and Biological Sciences Research Council
    2016 - 2019
     
  • Protein antibiotics for the treatment of Pseudomonas aeruginosa lung infection
    Medical Research Council
    2016 - 2019
     
  • Development of novel cancer targeting bacterial strains as delivery vehicles for anti-tumour genes
    Tenovus Scotland
    2014 - 2015
     
  • Survival and dissemination of enteric pathogens through exploitation and inhibition of programmed cell death pathways in circulating immune cells.
    Biotechnology and Biological Sciences Research Council
    2013 - 2016
     
  • Deciphering and harnessing the activation of caspase-3 during infection by Salmonella typhimurium
    Microbiology Society
    2010 - 2010
     
  • Controlled induction of apoptotic enzymes by Salmonella typhimurium drives infection and inflammation
    Tenovus Scotland
    2010 - 2011
     

Supervision

  • Dritsa, Clio
    Application of Imaging and Omics to Understand Communication Across the Microbiome-Gut-Brain axis

Additional information

Invited International Presentations

  • 2011: Tenovus Scotland - Sir Robert MacLellan Award
  • 2011: University of Strathclyde, UK - "Exploitation of apoptosis by Salmonella Typhimurium"
  • 2007: Washington D.C., USA - Experimental Biology Annual General Meeting - Identification of the Salmonella typhimurium SipA functional domain required for intestinal inflammation.
  • 2005: Long Island, NY, USA - Cold Spring Harbor Laboratory Microbial Pathogenesis & Host Response meeting. Cold Spring Harbor Laboratory - The S. typhimurium effector protein SipA possesses two discrete functional domains for invasion and inflammation

Prizes, Awards and Distinctions

  • 2010: Society for General Microbiology - President's Award

Research Fellowship

  • 2010: University of Massachusetts, USA - Visiting Academic, University of Massachusetts Medical School, Molecular Genetics and Microbiology Department. Funded by the Society for General Microbiology, UK President's Fund.

A head and shoulders shot of Dr Donal Wall in the lab

Professor Daniel Wall on Twitter