Mr Craig Lapsley

  • Technician (Parasitology)

telephone: 6069
email: Craig.Lapsley@glasgow.ac.uk

RB624 Level B6, Iii - Gbrc, University Place, Glasgow G12 8TA

Import to contacts

Publications

List by: Type | Date

Jump to: 2025 | 2024 | 2023 | 2020 | 2019 | 2018 | 2016 | 2011
Number of items: 13.

2025

Damasceno, J. D. , Briggs, E. M., Krasilnikova, M. , Marques, C. A., Lapsley, C. and McCulloch, R. (2025) R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania. Nature Communications, 16, 1470. (doi: 10.1038/s41467-025-56785-y) (PMID:39922816) (PMCID:PMC11807225)

Krasilnikova, M. , Marques, C. A. , Briggs, E., Lapsley, C., Hamilton, G., Beraldi, D., Crouch, K. and McCulloch, R. (2025) Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei. Nature Communications, 16, 751. (doi: 10.1038/s41467-025-56087-3)

2024

Damasceno, J. , LA. Silva, G., Marques, C. A. , Krasilnikova, M. , Lapsley, C., Beraldi, D. and McCulloch, R. (2024) Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events. bioRxiv, (doi: 10.1101/2024.11.14.623610)

Damasceno, J. D. , Briggs, E. M., Krasilnikova, M. , Marques, C. A. , Lapsley, C. and McCulloch, R. (2024) R-loops acted on by RNase H1 are a determinant of chromosome length-associated DNA replication timing and genome stability in Leishmania. bioRxiv, (doi: 10.1101/2024.04.29.591643)

2023

Girasol, M. J. et al. (2023) RAD51-mediated R-loop formation acts to repair transcription associated DNA breaks driving antigenic variation in Trypanosoma brucei. Proceedings of the National Academy of Sciences of the United States of America, 120(48), e230930612. (doi: 10.1073/pnas.2309306120) (PMID:37988471) (PMCID:PMC10691351)

2020

Damasceno, J. D. , Marques, C. A. , Beraldi, D., Crouch, K. , Lapsley, C., Obonaga, R., Tosi, L. R.O. and McCulloch, R. (2020) Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication. eLife, 9, e58030. (doi: 10.7554/eLife.58030) (PMID:32897188) (PMCID:PMC7511235)

Damasceno, J. D. , Reis-Cunha, J., Crouch, K. , Beraldi, D., Lapsley, C., Tosi, L. R.O., Bartholomeu, D. and McCulloch, R. (2020) Conditional knockout of RAD51-related genes in Leishmania major reveals a critical role for homologous recombination during genome replication. PLoS Genetics, 16(7), e1008828. (doi: 10.1371/journal.pgen.1008828) (PMID:32609721) (PMCID:PMC7360064)

Black, J. A., Crouch, K. , Lemgruber, L. , Lapsley, C., Dickens, N. , Tosi, L. R.O., Mottram, J. C. and McCulloch, R. (2020) Trypanosoma brucei ATR links DNA damage signalling during antigenic variation with regulation of RNA Polymerase I-transcribed surface antigens. Cell Reports, 30(3), 836-851.e5. (doi: 10.1016/j.celrep.2019.12.049) (PMID:31968257) (PMCID:PMC6988115)

2019

Briggs, E., Crouch, K. , Lemgruber Soares, L. , Hamilton, G., Lapsley, C. and McCulloch, R. (2019) Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation. Nucleic Acids Research, 47(17), pp. 9180-9197. (doi: 10.1093/nar/gkz644) (PMID:31350892) (PMCID:PMC6753483)

2018

Briggs, E., Hamilton, G., Crouch, K. , Lapsley, C. and McCulloch, R. (2018) Genome-wide mapping reveals conserved and diverged R-loop activities in the unusual genetic landscape of the African trypanosome genome. Nucleic Acids Research, 46(22), pp. 11789-11805. (doi: 10.1093/nar/gky928) (PMID:30304482) (PMCID:PMC6294496)

Briggs, E., Crouch, K. , Lemgruber, L. , Lapsley, C. and McCulloch, R. (2018) Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion. PLoS Genetics, 14(12), e1007729. (doi: 10.1371/journal.pgen.1007729) (PMID:30543624) (PMCID:PMC6292569)

2016

Devlin, R., Marques, C. A. , Paape, D. , Prorocic, M., Zurita-Leal, A. C., Campbell, S. J., Lapsley, C., Dickens, N. and McCulloch, R. (2016) Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation. eLife, 5, e12765. (doi: 10.7554/eLife.12765) (PMID:27228154) (PMCID:PMC4946898)

2011

Dobson, R., Stockdale, C., Lapsley, C., Wilkes, J. and McCulloch, R. (2011) Interactions among Trypanosoma brucei RAD51 paralogues in DNA repair and antigenic variation. Molecular Microbiology, 81(2), pp. 434-456. (doi: 10.1111/j.1365-2958.2011.07703.x)

This list was generated on Mon Mar 10 23:03:59 2025 GMT.
Jump to: Articles
Number of items: 13.

Articles

Damasceno, J. D. , Briggs, E. M., Krasilnikova, M. , Marques, C. A., Lapsley, C. and McCulloch, R. (2025) R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania. Nature Communications, 16, 1470. (doi: 10.1038/s41467-025-56785-y) (PMID:39922816) (PMCID:PMC11807225)

Krasilnikova, M. , Marques, C. A. , Briggs, E., Lapsley, C., Hamilton, G., Beraldi, D., Crouch, K. and McCulloch, R. (2025) Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei. Nature Communications, 16, 751. (doi: 10.1038/s41467-025-56087-3)

Damasceno, J. , LA. Silva, G., Marques, C. A. , Krasilnikova, M. , Lapsley, C., Beraldi, D. and McCulloch, R. (2024) Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events. bioRxiv, (doi: 10.1101/2024.11.14.623610)

Damasceno, J. D. , Briggs, E. M., Krasilnikova, M. , Marques, C. A. , Lapsley, C. and McCulloch, R. (2024) R-loops acted on by RNase H1 are a determinant of chromosome length-associated DNA replication timing and genome stability in Leishmania. bioRxiv, (doi: 10.1101/2024.04.29.591643)

Girasol, M. J. et al. (2023) RAD51-mediated R-loop formation acts to repair transcription associated DNA breaks driving antigenic variation in Trypanosoma brucei. Proceedings of the National Academy of Sciences of the United States of America, 120(48), e230930612. (doi: 10.1073/pnas.2309306120) (PMID:37988471) (PMCID:PMC10691351)

Damasceno, J. D. , Marques, C. A. , Beraldi, D., Crouch, K. , Lapsley, C., Obonaga, R., Tosi, L. R.O. and McCulloch, R. (2020) Genome duplication in Leishmania major relies on persistent subtelomeric DNA replication. eLife, 9, e58030. (doi: 10.7554/eLife.58030) (PMID:32897188) (PMCID:PMC7511235)

Damasceno, J. D. , Reis-Cunha, J., Crouch, K. , Beraldi, D., Lapsley, C., Tosi, L. R.O., Bartholomeu, D. and McCulloch, R. (2020) Conditional knockout of RAD51-related genes in Leishmania major reveals a critical role for homologous recombination during genome replication. PLoS Genetics, 16(7), e1008828. (doi: 10.1371/journal.pgen.1008828) (PMID:32609721) (PMCID:PMC7360064)

Black, J. A., Crouch, K. , Lemgruber, L. , Lapsley, C., Dickens, N. , Tosi, L. R.O., Mottram, J. C. and McCulloch, R. (2020) Trypanosoma brucei ATR links DNA damage signalling during antigenic variation with regulation of RNA Polymerase I-transcribed surface antigens. Cell Reports, 30(3), 836-851.e5. (doi: 10.1016/j.celrep.2019.12.049) (PMID:31968257) (PMCID:PMC6988115)

Briggs, E., Crouch, K. , Lemgruber Soares, L. , Hamilton, G., Lapsley, C. and McCulloch, R. (2019) Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation. Nucleic Acids Research, 47(17), pp. 9180-9197. (doi: 10.1093/nar/gkz644) (PMID:31350892) (PMCID:PMC6753483)

Briggs, E., Hamilton, G., Crouch, K. , Lapsley, C. and McCulloch, R. (2018) Genome-wide mapping reveals conserved and diverged R-loop activities in the unusual genetic landscape of the African trypanosome genome. Nucleic Acids Research, 46(22), pp. 11789-11805. (doi: 10.1093/nar/gky928) (PMID:30304482) (PMCID:PMC6294496)

Briggs, E., Crouch, K. , Lemgruber, L. , Lapsley, C. and McCulloch, R. (2018) Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion. PLoS Genetics, 14(12), e1007729. (doi: 10.1371/journal.pgen.1007729) (PMID:30543624) (PMCID:PMC6292569)

Devlin, R., Marques, C. A. , Paape, D. , Prorocic, M., Zurita-Leal, A. C., Campbell, S. J., Lapsley, C., Dickens, N. and McCulloch, R. (2016) Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation. eLife, 5, e12765. (doi: 10.7554/eLife.12765) (PMID:27228154) (PMCID:PMC4946898)

Dobson, R., Stockdale, C., Lapsley, C., Wilkes, J. and McCulloch, R. (2011) Interactions among Trypanosoma brucei RAD51 paralogues in DNA repair and antigenic variation. Molecular Microbiology, 81(2), pp. 434-456. (doi: 10.1111/j.1365-2958.2011.07703.x)

This list was generated on Mon Mar 10 23:03:59 2025 GMT.