Dr Christopher Moxon

  • Clinical Senior Lecturer (Parasitology)

Biography

Chris Moxon is a Clinical Senior Lecturer at the Wellcome Centre for Integrative Parasitology, University of Glasgow and an honorary consultant in Paediatric Infectious Diseases at the Royal Hospital for Children. He obtained his medical degree from St. Bartholomew’s and the Royal London and a BSc in Developmental Neurobiology at King’s College. After gaining membership of the Royal College of Paediatrics, his Liverpool-Wellcome Trust clinical PhD fellowship, focused on the role of coagulation in cerebral malaria at Malawi-Liverpool-Wellcome Clinical Research Programme. Then as a clinical lecturer in Liverpool while training in paediatric infectious diseases his research took a more basic approach, to understand the mechanisms of his PhD observations: developing in vitro methods and using laser capture microdissection to examine specific cell populations using transcriptomics in patient samples. This included a period as a visiting scientist at Havard Medical School/ Brigham and Women's Centre for Excellence in Vascular Biology in the Garcia-Cardeña lab, funded by a Wellcome Trust Seed Award. Having moved to University of Glasgow in September his work will interface between primary examination of host:pathogen interactions in patient samples in Blantyre Malawi (largely in post-mortem tissue) and mechanistic examination in the lab; both leveraging multi-modal technologies available at the WCMP/ UoG.  These will examine mechanisms of transmission and pathogenesis – with a particular focus on understanding brain swelling in cerebral malaria with view to identifying treatment targets. 

Research interests

I focus on cerebral malaria pathogenesis and host:pathogen interactions in malaria using multi-model technologies. In particular I am interested in brain swelling in cerebral malaria with view to identifying treatment targets. 

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008
Number of items: 32.

2024

Nyirenda, J. et al. (2024) Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population. Nature Medicine, (doi: 10.1038/s41591-024-03354-3) (Early Online Publication)

Da Silva Filho, J. et al. (2024) A spatially resolved single-cell lung atlas integrated with clinical and blood signatures distinguishes COVID-19 disease trajectories. Science Translational Medicine, 16(764), eadk9149. (doi: 10.1126/scitranslmed.adk9149) (PMID:39259811)

Abrams, S. T. et al. (2024) Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia. Journal of Thrombosis and Haemostasis, 22(4), pp. 1145-1153. (doi: 10.1016/j.jtha.2023.12.008) (PMID:38103733)

2023

Nyirenda, J. et al. (2023) Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated response. bioRxiv, (doi: 10.1101/2023.11.16.566964)

2022

Hentzschel, F., Gibbins, M. P. , Attipa, C., Beraldi, D., Moxon, C. A. , Otto, T. D. and Marti, M. (2022) Host cell maturation modulates parasite invasion and sexual differentiation in Plasmodium berghei. Science Advances, 8(17), eabm7348. (doi: 10.1126/sciadv.abm7348) (PMID:35476438) (PMCID:PMC9045723)

2021

Meibalan, E. et al. (2021) Plasmodium falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers in Burkina Faso. Journal of Infectious Diseases, 223(10), pp. 1822-1830. (doi: 10.1093/infdis/jiz680) (PMID:31875909) (PMCID:PMC8161640)

Chaziya, J. et al. (2021) COVID-19 in Malawi: lessons in pandemic preparedness from a tertiary children’s hospital. Archives of Disease in Childhood, 106, pp. 238-240. (doi: 10.1136/archdischild-2020-319980) (PMID:33361067) (PMCID:PMC7768613)

Feutz, E. et al. (2021) Minimally invasive postmortem intestinal tissue sampling in malnourished and acutely ill children is feasible and informative. Clinical Infectious Diseases, 73(Suppl5), S382-S389. (doi: 10.1093/cid/ciab790) (PMID:34910181) (PMCID:PMC8672761)

Georgiadou, A., Naidu, P., Walsh, S., Kamiza, S., Barrera, V., Harding, S. P., Moxon, C. A. and Cunnington, A. J. (2021) Localised release of matrix metallopeptidase 8 in fatal cerebral malaria. Clinical and Translational Immunology, 10(4), e1263. (doi: 10.1002/cti2.1263) (PMID:33968402) (PMCID:PMC8082700)

2020

Moxon, C. A. et al. (2020) Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria. Blood Advances, 4(13), pp. 2851-2864. (doi: 10.1182/bloodadvances.2019001258) (PMID:32579667) (PMCID:PMC7362376)

Storm, J., Wu, Y., Davies, J., Moxon, C. A. and Craig, A. G. (2020) Testing the effect of PAR1 inhibitors on Plasmodium falciparum-induced loss of endothelial cell barrier function. Wellcome Open Research, 5, 34. (doi: 10.12688/wellcomeopenres.15602.3) (PMID:32724861) (PMCID:PMC7364184)

Amulic, B., Moxon, C. A. and Cunnington, A. J. (2020) A more granular view of neutrophils in malaria. Trends in Parasitology, 36(6), pp. 501-503. (doi: 10.1016/j.pt.2020.03.003) (PMID:32407680)

Moxon, C. A. , Gibbins, M. P. , McGuinness, D., Milner, D. A. and Marti, M. (2020) New insights into malaria pathogenesis. Annual Review of Pathology: Mechanisms of Disease, 15(1), pp. 315-343. (doi: 10.1146/annurev-pathmechdis-012419-032640) (PMID:31648610)

2019

Knackstedt, S. L. et al. (2019) Neutrophil extracellular traps drive inflammatory pathogenesis in malaria. Science Immunology, 4(40), eaaw0336. (doi: 10.1126/sciimmunol.aaw0336) (PMID:31628160)

Levin, M. et al. (2019) Effects of saline or albumin fluid bolus in resuscitation: evidence from re-analysis of the FEAST trial. Lancet Respiratory Medicine, 7(7), pp. 581-593. (doi: 10.1016/S2213-2600(19)30114-6) (PMID:31196803) (PMCID:PMC6593355)

Storm, J. et al. (2019) Cerebral malaria is associated with differential cytoadherence to brain endothelial cells. EMBO Molecular Medicine, 11(2), e9164. (doi: 10.15252/emmm.201809164) (PMID:30610112) (PMCID:PMC6365927)

2016

Moxon, C. A. et al. (2016) Safety of lumbar puncture in comatose children with clinical features of cerebral malaria. Neurology, 87(22), pp. 2355-2362. (doi: 10.1212/WNL.0000000000003372) (PMID:27794112) (PMCID:PMC5135026)

Mbale, E. W. et al. (2016) HIV coinfection influences the inflammatory response but not the outcome of cerebral malaria in Malawian children. Journal of Infection, 73(3), pp. 189-199. (doi: 10.1016/j.jinf.2016.05.012) (PMID:27311750) (PMCID:PMC4990000)

Moxon, C. A. and Paulus, S. (2016) Beta-lactamases in Enterobacteriaceae infections in children. Journal of Infection, 72(Suppl), S41-S49. (doi: 10.1016/j.jinf.2016.04.021) (PMID:27180312)

Craig, A. G., Brophy, T. M., Preston, R. J.S., Smith, O. P., Chion, A., O’Sullivan, J., Gegenbauer, K., O’Regan, N., Moxon, C. and O’Donnell, J. S. (2016) Marked elevation in plasma osteoprotegerin constitutes an early and consistent feature of cerebral malaria. Thrombosis and Haemostasis, 115(4), pp. 773-780. (doi: 10.1160/TH15-10-0796) (PMID:26766771) (PMCID:PMC4990170)

2015

Moxon, C.A. et al. (2015) Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding. Journal of Thrombosis and Haemostasis, 13(9), pp. 1653-1664. (doi: 10.1111/jth.13060) (PMID:26186686) (PMCID:PMC4605993)

2014

Moxon, C. A. et al. (2014) Persistent endothelial activation and inflammation after Plasmodium falciparum infection in Malawian children. Journal of Infectious Diseases, 209(4), pp. 610-615. (doi: 10.1093/infdis/jit419) (PMID:24048963) (PMCID:PMC3903368)

2013

Moxon, C. A. et al. (2013) Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children. Blood, 122(5), pp. 842-851. (doi: 10.1182/blood-2013-03-490219) (PMID:23741007) (PMCID:PMC3731936)

Moxon, C. (2013) New twist in age-old war against malaria parasite. Conversation, 5 Jul.

Katangwe, T. et al. (2013) Human melioidosis, Malawi, 2011. Emerging Infectious Diseases, 19(6), pp. 981-984. (doi: 10.3201/eid1906.120717) (PMID:23735189) (PMCID:PMC3713813)

2012

Moxon, C.A. (2012) Fighting malaria at the source. International Innovation, Nov, pp. 69-71.

2011

Moxon, C. A. , Grau, G. E. and Craig, A. G. (2011) Malaria: modification of the red blood cell and consequences in the human host. British Journal of Haematology, 154(6), pp. 670-679. (doi: 10.1111/j.1365-2141.2011.08755.x) (PMID:21623767) (PMCID:PMC3557659)

Wassmer, S. C., Moxon, C. A. , Taylor, T., Grau, G. E., Molyneux, M. E. and Craig, A. G. (2011) Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF. Cellular Microbiology, 13(2), pp. 198-209. (doi: 10.1111/j.1462-5822.2010.01528.x) (PMID:21029292) (PMCID:PMC3041929)

2010

Formstone, C. J., Moxon, C. , Murdoch, J., Little, P. and Mason, I. (2010) Basal enrichment within neuroepithelia suggests novel function(s) for Celsr1 protein. Molecular and Cellular Neuroscience, 44(3), pp. 210-222. (doi: 10.1016/j.mcn.2010.03.008) (PMID:20353824)

2009

Moxon, C. A. , Heyderman, R. S. and Wassmer, S. C. (2009) Dysregulation of coagulation in cerebral malaria. Molecular and Biochemical Parasitology, 166(2), pp. 99-108. (doi: 10.1016/j.molbiopara.2009.03.006) (PMID:19450727) (PMCID:PMC2724037)

2008

Windsor, J., Imray, C., Rodway, G., Roberts, B., Moxon, C. , Pollard, C. and Clarke, C. (2008) Mountains and high altitude. In: Johnson, C. (ed.) Oxford Handbook of Expedition and Wilderness Medicine. Series: Oxford handbooks. Oxford University Press: Oxford ; New York, pp. 607-632. ISBN 9780199296613 (doi: 10.1093/med/9780199296613.003.0020)

Moxon, C. and Wills, B. (2008) Management of severe dengue in children. In: Finn, A. and Pollard, A. J. (eds.) Hot Topics in Infection and Immunity in Children IV. Series: Advances in experimental medicine and biology (609). Springer: New York, NY, pp. 131-144. ISBN 9780387739595 (doi: 10.1007/978-0-387-73960-1_10)

This list was generated on Fri Dec 20 22:00:39 2024 GMT.
Jump to: Articles | Book Sections
Number of items: 32.

Articles

Nyirenda, J. et al. (2024) Spatially resolved single-cell atlas unveils a distinct cellular signature of fatal lung COVID-19 in a Malawian population. Nature Medicine, (doi: 10.1038/s41591-024-03354-3) (Early Online Publication)

Da Silva Filho, J. et al. (2024) A spatially resolved single-cell lung atlas integrated with clinical and blood signatures distinguishes COVID-19 disease trajectories. Science Translational Medicine, 16(764), eadk9149. (doi: 10.1126/scitranslmed.adk9149) (PMID:39259811)

Abrams, S. T. et al. (2024) Damage-associated cellular markers in the clinical and pathogenic profile of vaccine-induced immune thrombotic thrombocytopenia. Journal of Thrombosis and Haemostasis, 22(4), pp. 1145-1153. (doi: 10.1016/j.jtha.2023.12.008) (PMID:38103733)

Nyirenda, J. et al. (2023) Spatially resolved single-cell atlas of the lung in fatal Covid19 in an African population reveals a distinct cellular signature and an interferon gamma dominated response. bioRxiv, (doi: 10.1101/2023.11.16.566964)

Hentzschel, F., Gibbins, M. P. , Attipa, C., Beraldi, D., Moxon, C. A. , Otto, T. D. and Marti, M. (2022) Host cell maturation modulates parasite invasion and sexual differentiation in Plasmodium berghei. Science Advances, 8(17), eabm7348. (doi: 10.1126/sciadv.abm7348) (PMID:35476438) (PMCID:PMC9045723)

Meibalan, E. et al. (2021) Plasmodium falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers in Burkina Faso. Journal of Infectious Diseases, 223(10), pp. 1822-1830. (doi: 10.1093/infdis/jiz680) (PMID:31875909) (PMCID:PMC8161640)

Chaziya, J. et al. (2021) COVID-19 in Malawi: lessons in pandemic preparedness from a tertiary children’s hospital. Archives of Disease in Childhood, 106, pp. 238-240. (doi: 10.1136/archdischild-2020-319980) (PMID:33361067) (PMCID:PMC7768613)

Feutz, E. et al. (2021) Minimally invasive postmortem intestinal tissue sampling in malnourished and acutely ill children is feasible and informative. Clinical Infectious Diseases, 73(Suppl5), S382-S389. (doi: 10.1093/cid/ciab790) (PMID:34910181) (PMCID:PMC8672761)

Georgiadou, A., Naidu, P., Walsh, S., Kamiza, S., Barrera, V., Harding, S. P., Moxon, C. A. and Cunnington, A. J. (2021) Localised release of matrix metallopeptidase 8 in fatal cerebral malaria. Clinical and Translational Immunology, 10(4), e1263. (doi: 10.1002/cti2.1263) (PMID:33968402) (PMCID:PMC8082700)

Moxon, C. A. et al. (2020) Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria. Blood Advances, 4(13), pp. 2851-2864. (doi: 10.1182/bloodadvances.2019001258) (PMID:32579667) (PMCID:PMC7362376)

Storm, J., Wu, Y., Davies, J., Moxon, C. A. and Craig, A. G. (2020) Testing the effect of PAR1 inhibitors on Plasmodium falciparum-induced loss of endothelial cell barrier function. Wellcome Open Research, 5, 34. (doi: 10.12688/wellcomeopenres.15602.3) (PMID:32724861) (PMCID:PMC7364184)

Amulic, B., Moxon, C. A. and Cunnington, A. J. (2020) A more granular view of neutrophils in malaria. Trends in Parasitology, 36(6), pp. 501-503. (doi: 10.1016/j.pt.2020.03.003) (PMID:32407680)

Moxon, C. A. , Gibbins, M. P. , McGuinness, D., Milner, D. A. and Marti, M. (2020) New insights into malaria pathogenesis. Annual Review of Pathology: Mechanisms of Disease, 15(1), pp. 315-343. (doi: 10.1146/annurev-pathmechdis-012419-032640) (PMID:31648610)

Knackstedt, S. L. et al. (2019) Neutrophil extracellular traps drive inflammatory pathogenesis in malaria. Science Immunology, 4(40), eaaw0336. (doi: 10.1126/sciimmunol.aaw0336) (PMID:31628160)

Levin, M. et al. (2019) Effects of saline or albumin fluid bolus in resuscitation: evidence from re-analysis of the FEAST trial. Lancet Respiratory Medicine, 7(7), pp. 581-593. (doi: 10.1016/S2213-2600(19)30114-6) (PMID:31196803) (PMCID:PMC6593355)

Storm, J. et al. (2019) Cerebral malaria is associated with differential cytoadherence to brain endothelial cells. EMBO Molecular Medicine, 11(2), e9164. (doi: 10.15252/emmm.201809164) (PMID:30610112) (PMCID:PMC6365927)

Moxon, C. A. et al. (2016) Safety of lumbar puncture in comatose children with clinical features of cerebral malaria. Neurology, 87(22), pp. 2355-2362. (doi: 10.1212/WNL.0000000000003372) (PMID:27794112) (PMCID:PMC5135026)

Mbale, E. W. et al. (2016) HIV coinfection influences the inflammatory response but not the outcome of cerebral malaria in Malawian children. Journal of Infection, 73(3), pp. 189-199. (doi: 10.1016/j.jinf.2016.05.012) (PMID:27311750) (PMCID:PMC4990000)

Moxon, C. A. and Paulus, S. (2016) Beta-lactamases in Enterobacteriaceae infections in children. Journal of Infection, 72(Suppl), S41-S49. (doi: 10.1016/j.jinf.2016.04.021) (PMID:27180312)

Craig, A. G., Brophy, T. M., Preston, R. J.S., Smith, O. P., Chion, A., O’Sullivan, J., Gegenbauer, K., O’Regan, N., Moxon, C. and O’Donnell, J. S. (2016) Marked elevation in plasma osteoprotegerin constitutes an early and consistent feature of cerebral malaria. Thrombosis and Haemostasis, 115(4), pp. 773-780. (doi: 10.1160/TH15-10-0796) (PMID:26766771) (PMCID:PMC4990170)

Moxon, C.A. et al. (2015) Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding. Journal of Thrombosis and Haemostasis, 13(9), pp. 1653-1664. (doi: 10.1111/jth.13060) (PMID:26186686) (PMCID:PMC4605993)

Moxon, C. A. et al. (2014) Persistent endothelial activation and inflammation after Plasmodium falciparum infection in Malawian children. Journal of Infectious Diseases, 209(4), pp. 610-615. (doi: 10.1093/infdis/jit419) (PMID:24048963) (PMCID:PMC3903368)

Moxon, C. A. et al. (2013) Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children. Blood, 122(5), pp. 842-851. (doi: 10.1182/blood-2013-03-490219) (PMID:23741007) (PMCID:PMC3731936)

Moxon, C. (2013) New twist in age-old war against malaria parasite. Conversation, 5 Jul.

Katangwe, T. et al. (2013) Human melioidosis, Malawi, 2011. Emerging Infectious Diseases, 19(6), pp. 981-984. (doi: 10.3201/eid1906.120717) (PMID:23735189) (PMCID:PMC3713813)

Moxon, C.A. (2012) Fighting malaria at the source. International Innovation, Nov, pp. 69-71.

Moxon, C. A. , Grau, G. E. and Craig, A. G. (2011) Malaria: modification of the red blood cell and consequences in the human host. British Journal of Haematology, 154(6), pp. 670-679. (doi: 10.1111/j.1365-2141.2011.08755.x) (PMID:21623767) (PMCID:PMC3557659)

Wassmer, S. C., Moxon, C. A. , Taylor, T., Grau, G. E., Molyneux, M. E. and Craig, A. G. (2011) Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF. Cellular Microbiology, 13(2), pp. 198-209. (doi: 10.1111/j.1462-5822.2010.01528.x) (PMID:21029292) (PMCID:PMC3041929)

Formstone, C. J., Moxon, C. , Murdoch, J., Little, P. and Mason, I. (2010) Basal enrichment within neuroepithelia suggests novel function(s) for Celsr1 protein. Molecular and Cellular Neuroscience, 44(3), pp. 210-222. (doi: 10.1016/j.mcn.2010.03.008) (PMID:20353824)

Moxon, C. A. , Heyderman, R. S. and Wassmer, S. C. (2009) Dysregulation of coagulation in cerebral malaria. Molecular and Biochemical Parasitology, 166(2), pp. 99-108. (doi: 10.1016/j.molbiopara.2009.03.006) (PMID:19450727) (PMCID:PMC2724037)

Book Sections

Windsor, J., Imray, C., Rodway, G., Roberts, B., Moxon, C. , Pollard, C. and Clarke, C. (2008) Mountains and high altitude. In: Johnson, C. (ed.) Oxford Handbook of Expedition and Wilderness Medicine. Series: Oxford handbooks. Oxford University Press: Oxford ; New York, pp. 607-632. ISBN 9780199296613 (doi: 10.1093/med/9780199296613.003.0020)

Moxon, C. and Wills, B. (2008) Management of severe dengue in children. In: Finn, A. and Pollard, A. J. (eds.) Hot Topics in Infection and Immunity in Children IV. Series: Advances in experimental medicine and biology (609). Springer: New York, NY, pp. 131-144. ISBN 9780387739595 (doi: 10.1007/978-0-387-73960-1_10)

This list was generated on Fri Dec 20 22:00:39 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Sepsis treatment by targeting antibiotic released bacterial proteins (STTAR-BacPro)
    Medical Research Council
    2024 - 2024
     
  • Single cell interrogation of the blood-brain barrier in human cerebral malaria: a translational approach
    UK Research and Innovation
    2022 - 2025
     
  • Understanding vaccine response at the cellular level: the MAVRIC study (Malawi Atlas of Vaccine Response in an Infant Cohort)
    Wellcome Trust
    2021 - 2022
     
  • MITS for lung pathology and immune response in fatal COVID-19 in Malawi
    Bill and Melinda Gates Foundation
    2020 - 2021
     
  • Role of histones and histone-like proteins in coagulopathy and vascular leak in meningococcal disease in children: a potential biomarker or target for adjunctive treatment.
    Chief Scientist Office
    2020 - 2021
     

Chris Moxon Staff profile