Dr Adam Fletcher

Research Fellow: UKRI Future Leadership Fellow (Virology)

telephone: 01413304557
email: Adam.Fletcher@glasgow.ac.uk
pronouns: He/him/his

Import to contacts

https://orcid.org/0000-0003-1742-6588

Publications

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Number of items: 18.

2021

De Cesare, V., Carbajo Lopez, D., Mabbitt, P. D., Fletcher, A. J. , Soetens, M., Antico, O., Wood, N. T. and Virdee, S. (2021) Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases. Proceedings of the National Academy of Sciences, 118(4), e200694711. (doi: 10.1073/pnas.2006947118) (PMID:33479176) (PMCID:PMC7848729)

2020

Mabbitt, P. D., Loreto, A., Déry, M.-A., Fletcher, A. J. , Stanley, M., Pao, K.-C., Wood, N. T., Coleman, M. P. and Virdee, S. (2020) Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity. Nature Chemical Biology, 16(11), pp. 1227-1236. (doi: 10.1038/s41589-020-0598-6) (PMID:32747811) (PMCID:PMC7610530)

2019

Mallery, D. L. et al. (2019) Cellular IP6 levels limit HIV production while viruses that cannot efficiently package IP6 are attenuated for infection and replication. Cell Reports, 29(12), 3983-3996.e4. (doi: 10.1016/j.celrep.2019.11.050) (PMID:31851928) (PMCID:PMC6931105)

Mathur, S., Fletcher, A. J. , Branigan, E., Hay, R. T. and Virdee, S. (2019) Photocrosslinking activity-based probes for ubiquitin RING E3 ligases. Cell Chemical Biology, 27(1), 74-82.e6. (doi: 10.1016/j.chembiol.2019.11.013) (PMID:31859248) (PMCID:PMC6963778)

2018

Fletcher, A. J. , Vaysburd, M., Maslen, S., Zeng, J., Skehel, J. M., Towers, G. J. and James, L. C. (2018) Trivalent RING assembly on retroviral capsids activates TRIM5 ubiquitination and innate immune signaling. Cell Host and Microbe, 24(6), 761-775.e6. (doi: 10.1016/j.chom.2018.10.007) (PMID:30503508) (PMCID:PMC6299210)

Dickson, C. et al. (2018) Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21. eLife, 7, e32660. (doi: 10.7554/eLife.32660) (PMID:29667579) (PMCID:PMC5906095)

2016

Fletcher, A. J. , James, L. C. and Tsai, B. (2016) Coordinated neutralization and immune activation by the cytosolic antibody receptor TRIM21. Journal of Virology, 90(10), pp. 4856-4859. (doi: 10.1128/JVI.00050-16) (PMID:26937031) (PMCID:PMC4859718)

2015

Fletcher, A. J. , Mallery, D. L., Watkinson, R. E., Dickson, C. F. and James, L. C. (2015) Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21. Proceedings of the National Academy of Sciences, 112(32), pp. 10014-10019. (doi: 10.1073/pnas.1507534112) (PMID:26150489) (PMCID:PMC4538650)

Fletcher, A. J. , Christensen, D. E., Nelson, C., Tan, C. P., Schaller, T., Lehner, P. J., Sundquist, W. I. and Towers, G. J. (2015) TRIM 5α requires Ube2W to anchor Lys63‐linked ubiquitin chains and restrict reverse transcription. EMBO Journal, 34(15), pp. 2078-2095. (doi: 10.15252/embj.201490361) (PMID:26101372) (PMCID:PMC4551353)

2014

Guiliano, D. B. et al. (2014) Endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 1 targets misfolded HLA-B27 dimers for endoplasmic reticulum-associated degradation. Arthritis and Rheumatology, 66(11), pp. 2976-2988. (doi: 10.1002/art.38809) (PMID:25132672) (PMCID:PMC4399817)

Cullen, B. R., Price, A. J., Jacques, D. A., McEwan, W. A., Fletcher, A. J. , Essig, S., Chin, J. W., Halambage, U. D., Aiken, C. and James, L. C. (2014) Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly. PLoS Pathogens, 10(10), e1004459. (doi: 10.1371/journal.ppat.1004459) (PMID:25356722) (PMCID:PMC4214760)

2013

Rasaiyaah, J. et al. (2013) HIV-1 evades innate immune recognition through specific cofactor recruitment. Nature, 503(7476), pp. 402-405. (doi: 10.1038/nature12769) (PMID:24196705) (PMCID:PMC3928559)

Fletcher, A. J. and Towers, G. J. (2013) Inhibition of retroviral replication by members of the TRIM protein family. In: Cullen, B. (ed.) Intrinsic Immunity. Series: Current topics in microbiology and immunology (371). Springer, pp. 29-66. ISBN 9783642377655 (doi: 10.1007/978-3-642-37765-5_2)

2012

Krausslich, H.-G., Price, A. J., Fletcher, A. J. , Schaller, T., Elliott, T., Lee, K., KewalRamani, V. N., Chin, J. W., Towers, G. J. and James, L. C. (2012) CPSF6 defines a conserved capsid interface that modulates HIV-1 replication. PLoS Pathogens, 8(8), e1002896. (doi: 10.1371/journal.ppat.1002896) (PMID:22956906) (PMCID:PMC3431306)

2011

Aiken, C. et al. (2011) HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency. PLoS Pathogens, 7(12), e1002439. (doi: 10.1371/journal.ppat.1002439) (PMID:22174692) (PMCID:PMC3234246)

2010

Fletcher, A. J. , Hué, S., Schaller, T., Pillay, D. and Towers, G. J. (2010) Hare TRIM5α restricts divergent retroviruses and exhibits significant sequence variation from closely related Lagomorpha TRIM5 genes. Journal of Virology, 84(23), pp. 12463-12468. (doi: 10.1128/jvi.01514-10) (PMID:20861252) (PMCID:PMC2976397)

Ylinen, L. M. J., Schaller, T., Price, A., Fletcher, A. J. , Noursadeghi, M., James, L. C. and Towers, G. J. (2010) Cyclophilin A levels dictate infection efficiency of human immunodeficiency virus type 1 capsid escape mutants A92E and G94D. Journal of Virology, 83(4), pp. 2044-2047. (doi: 10.1128/jvi.01876-08) (PMID:19073742) (PMCID:PMC2643744)

2008

Lyulcheva, E., Taylor, E., Michael, M., Vehlow, A., Tan, S., Fletcher, A. , Krause, M. and Bennett, D. (2008) Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation. Developmental Cell, 15(5), pp. 680-690. (doi: 10.1016/j.devcel.2008.09.020) (PMID:19000833) (PMCID:PMC2691947)

This list was generated on Fri Mar 28 11:41:09 2025 GMT.

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