2024

Muir, K. et al. (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23(11), pp. 1087-1096. (doi: 10.1016/S1474-4422(24)00377-6)

Foley, P.W. et al. (2024) Effect of correcting iron deficiency on the risk of serious infection in heart failure insights from the IRONMAN trial. European Journal of Heart Failure, (doi: 10.1002/ejhf.3504) (PMID:39453738) (Early Online Publication)

Lee, M. et al. (2024) Administration of ferric derisomaltose for iron deficiency and heart failure during hospital admission or at the clinic – insights from the IRONMAN trial. European Journal of Heart Failure, 26(10), pp. 2293-2295. (doi: 10.1002/ejhf.3394) (PMID:39078467)

Cleland, J. et al. (2024) The IRONMAN trial of intravenous iron for heart failure. Adjudication of hospitalizations and deaths. Journal of the American College of Cardiology, (Accepted for Publication)

Docherty, K. F. , McMurray, J. J.V. , Kalra, P., Cleland, J. G.F. , Lang, N. N. , Petrie, M. C. , Robertson, M. and Ford, I. (2024) Intravenous iron and SGLT2 inhibitors in iron-deficient patients with heart failure and reduced ejection fraction. ESC Heart Failure, 11(4), pp. 1875-1879. (doi: 10.1002/ehf2.14742) (PMID:38549192) (PMCID:PMC11287326)

Roger, G. et al. (2024) Chronic coronary syndromes without standard modifiable cardiovascular risk factors and outcomes: the CLARIFY registry. European Heart Journal, 45(27), pp. 2396-2406. (doi: 10.1093/eurheartj/ehae299)

Hageman, S. H..J. et al. (2024) Prediction of individual lifetime cardiovascular risk and potential treatment benefit: development and recalibration of the LIFE-CVD2 model to four European risk regions. European Journal of Preventive Cardiology, (doi: 10.1093/eurjpc/zwae174) (PMID:38752762) (Early Online Publication)

Ray, R. et al. (2024) The impact of ferric derisomaltose on cardiovascular and non-cardiovascular events in patients with anemia, iron deficiency and heart failure with reduced ejection fraction. Journal of Cardiac Failure, 30(5), pp. 682-690. (doi: 10.1016/j.cardfail.2023.10.006) (PMID:37926238) (PMCID:PMC11096866)

Cleland, J. G.F. et al. (2024) Intravenous iron for heart failure, iron deficiency definitions, and clinical response: the IRONMAN trial. European Heart Journal, 45(16), pp. 1410-1426. (doi: 10.1093/eurheartj/ehae086) (PMID:38446126) (PMCID:PMC11032711)

Suzuki, K. et al. (2024) Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature, 627(8003), pp. 347-357. (doi: 10.1038/s41586-024-07019-6) (PMID:38374256)

Mackenzie, I. S. et al. (2024) Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease: the ALL-HEART RCT and economic evaluation. Health Technology Assessment, 28(18), pp. 1-55. (doi: 10.3310/ATTM4092) (PMID:38551218)

MacKenzie, R. M. et al. (2024) Clinical outcomes and adverse events of bariatric surgery in adults with severe obesity in Scotland: the SCOTS observational cohort study. Health Technology Assessment, 28(7), (doi: 10.3310/UNAW6331)

2023

Stähli, B. E. et al. (2023) Timing of complete revascularization with multivessel PCI for myocardial infarction. New England Journal of Medicine, 389(15), pp. 1368-1379. (doi: 10.1056/NEJMoa2307823) (PMID:37634190)

Abdin, A., Komajda, M., Borer, J. S., Ford, I. , Tavazzi, L., Batailler, C., Swedberg, K., Rosano, G. M.C., Mahfoud, F. and Böhm, M. (2023) Efficacy of ivabradine in heart failure patients with a high-risk profile (analysis from the SHIFT trial). ESC Heart Failure, 10(5), pp. 2895-2902. (doi: 10.1002/ehf2.14455) (PMID:37427483) (PMCID:PMC10567656)

Abtan, J. et al. (2023) Association between coffee or tea consumption and cardiovascular outcomes in patients with stable coronary artery disease: Analysis from the CLARIFY registry. Archives of Cardiovascular Diseases, 116(8-9), pp. 382-389. (doi: 10.1016/j.acvd.2023.05.007) (PMID:37524628)

Gautier, A., Picard, F., Ducrocq, G., Elbez, Y., Fox, K. M., Ferrari, R., Ford, I. , Tardif, J.-C., Tendera, M. and Steg, P. G. (2023) New-onset atrial fibrillation in chronic coronary syndrome: the CLARIFY registry. European Heart Journal, (doi: 10.1093/eurheartj/ehad556) (PMID:37634147) (Early Online Publication)

Böhm, M., Abdin, A., Slawik, J., Mahfoud, F., Borer, J., Ford, I. , Swedberg, K., Tavazzi, L., Batailler, C. and Komajda, M. (2023) Time to benefit of heart rate reduction with ivabradine in patients with heart failure and reduced ejection fraction. European Journal of Heart Failure, 25(8), pp. 1429-1435. (doi: 10.1002/ejhf.2870) (PMID:37092340)

Vidal-Petiot, E., Elbez, Y., Mesnier, J., Ducrocq, G., Ford, I. , Tendera, M., Ferrari, R., Tardif, J.-C., Fox, K. M. and Steg, P. G. (2023) Optimal or standard control of systolic and diastolic blood pressure across risk factor categories in patients with chronic coronary syndromes. European Journal of Preventive Cardiology, 30(10), pp. 935-947. (doi: 10.1093/eurjpc/zwad004) (PMID:36617264)

Ford, I. and Kalra, P. R. (2023) Unanswered questions from the IRONMAN trial - authors' reply. Lancet, 401(10387), pp. 1495-1496. (doi: 10.1016/S0140-6736(23)00448-8) (PMID:37149301)

Graham, F. J., Pellicori, P. , Kalra, P. R., Ford, I. , Bruzzese, D. and Cleland, J. G.F. (2023) Intravenous iron in patients with heart failure and iron deficiency: an updated meta-analysis. European Journal of Heart Failure, 25(4), pp. 528-537. (doi: 10.1002/ejhf.2810) (PMID:36823953)

Bhandari, S. et al. (2023) Predictors of quality of life in patients within the first year of commencing haemodialysis based on baseline data from the PIVOTAL trial and associations with the study outcomes. Journal of Nephrology, (doi: 10.1007/s40620-023-01571-6) (PMID:36995528) (PMCID:PMC10061401) (Early Online Publication)

Hlatky, M. A. et al. (2023) Randomized comparison of chest pain evaluation with FFRCT or standard care: factors determining US costs. Journal of Cardiovascular Computed Tomography, 17(1), pp. 52-59. (doi: 10.1016/j.jcct.2022.09.005) (PMID:36216700)

Petrie, M. C. et al. (2023) High-dose intravenous iron reduces myocardial infarction in patients on haemodialysis. Cardiovascular Research, 119(1), pp. 213-220. (doi: 10.1093/cvr/cvab317) (PMID:34875022) (PMCID:PMC10022850)

2022

Kalra, P. R. et al. (2022) Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial. Lancet, 400(10369), pp. 2199-2209. (doi: 10.1016/S0140-6736(22)02083-9) (PMID:36347265)

Kalra, P. R. et al. (2022) Rationale and design of a randomised trial of intravenous iron in patients with heart failure. Heart, 108(24), pp. 1979-1985. (doi: 10.1136/heartjnl-2022-321304) (PMID:35948408) (PMCID:PMC9726969)

Lahti, J. et al. (2022) Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning. Molecular Psychiatry, 27(11), pp. 4419-4431. (doi: 10.1038/s41380-022-01710-8) (PMID:35974141) (PMCID:PMC9734053)

Yengo, L. et al. (2022) A saturated map of common genetic variants associated with human height. Nature Communications, 610, pp. 704-712. (doi: 10.1038/s41586-022-05275-y) (PMID:36224396) (PMCID:PMC9605867)

Mackenzie, I. S. et al. (2022) Cardiovascular outcomes in adults with hypertension with evening versus morning dosing of usual antihypertensives in the UK (TIME study): a prospective, randomised, open-label, blinded-endpoint clinical trial. Lancet, 400(10361), pp. 1417-1425. (doi: 10.1016/S0140-6736(22)01786-X) (PMID:36240838) (PMCID:PMC9631239)

Mackenzie, I. S. et al. (2022) Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial. Lancet, 400(10359), pp. 1195-1205. (doi: 10.1016/S0140-6736(22)01657-9) (PMID:36216006)

Wickens, O., Rengarajan, S., Chinnadurai, R., Ford, I. , Macdougall, I. C., Kalra, P. A. and Sinha, S. (2022) The role of iron in calciphylaxis—a current review. Journal of Clinical Medicine, 11(19), 5779. (doi: 10.3390/jcm11195779) (PMID:36233647) (PMCID:PMC9570530)

Thomson, P. C. et al. (2022) An analysis of vascular access thrombosis events from the Proactive IV Iron Therapy in Hemodialysis Patients (PIVOTAL) trial. Kidney International Reports, 7(8), pp. 1793-1801. (doi: 10.1016/j.ekir.2022.05.008) (PMID:35967105) (PMCID:PMC9366296)

Bularga, A. et al. (2022) Assessment of oxygen supply-demand imbalance and outcomes among patients with type 2 myocardial infarction: a secondary analysis of the High-STEACS cluster randomized clinical trial. JAMA Network Open, 5(7), e2220162. (doi: 10.1001/jamanetworkopen.2022.20162) (PMID:35816305) (PMCID:PMC9274319)

Siland, J. E. et al. (2022) Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium. PLoS ONE, 17(5), e0268768. (doi: 10.1371/journal.pone.0268768) (PMID:35594314) (PMCID:PMC9122202)

Mahajan, A. et al. (2022) Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nature Genetics, 54(5), pp. 560-572. (doi: 10.1038/s41588-022-01058-3) (PMID:35551307)

Gautier, A., Ducrocq, G., Elbez, Y., Fox, K. M., Ferrari, R., Ford, I. , Tardif, J.-C., Tendera, M., Feldman, L. J. and Steg, P. G. (2022) Cardiovascular risk of chronic coronary syndrome patients according to vascular phenotype, diabetes, and smoking. European Journal of Preventive Cardiology, 29(1), e35-e37. (doi: 10.1093/eurjpc/zwaa137) (PMID:33624093)

2021

Lumbers, R. T. et al. (2021) The genomics of heart failure: design and rationale of the HERMES consortium. ESC Heart Failure, 8(6), pp. 5531-5541. (doi: 10.1002/ehf2.13517) (PMID:34480422) (PMCID:PMC8712846)

Mak, K.-H. et al. (2021) Prevalence of diabetes and impact on cardiovascular events and mortality in patients with chronic coronary syndromes, across multiple geographical regions and ethnicities. European Journal of Preventive Cardiology, 28(16), pp. 1795-1806. (doi: 10.1093/eurjpc/zwab011) (PMID:35022686)

Mark, P. B. et al. (2021) Stroke in hemodialysis patients randomized to different intravenous iron strategies: a prespecified analysis from the PIVOTAL trial. Kidney360, 2(11), pp. 1761-1769. (doi: 10.34067/KID.0004272021)

Bouabdallaoui, N. et al. (2021) Impact of smoking on cardiovascular outcomes in patients with stable coronary artery disease. European Journal of Preventive Cardiology, 28(13), pp. 1460-1466. (doi: 10.1177/2047487320918728) (PMID:32340463)

Curzen, N. et al. (2021) Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial. European Heart Journal, 42(37), pp. 3844-3852. (doi: 10.1093/eurheartj/ehab444) (PMID:34269376)

Mesnier, J., Ducrocq, G., Danchin, N., Ferrari, R., Ford, I. , Tardif, J.-C., Tendera, M., Fox, K. M. and Steg, P. G. (2021) International observational analysis of evolution and outcomes of chronic stable angina: the multinational observational CLARIFY study. Circulation, 144(7), pp. 512-523. (doi: 10.1161/CIRCULATIONAHA.121.054567) (PMID:34261331)

Graham, F. J., Pellicori, P. , Ford, I. , Petrie, M. C. , Kalra, P. R. and Cleland, J. G.F. (2021) Intravenous iron for heart failure with evidence of iron deficiency: a meta-analysis of randomised trials. Clinical Research in Cardiology, 110(8), pp. 1299-1307. (doi: 10.1007/s00392-021-01837-8) (PMID:33755777)

Greenwood, S. A. et al. (2021) Randomized trial-PrEscription of intraDialytic exercise to improve quAlity of Life in patients receiving hemodialysis. Kidney International Reports, 6(8), pp. 2159-2170. (doi: 10.1016/j.ekir.2021.05.034) (PMID:34386665) (PMCID:PMC8343798)

Mackenzie, R. M. et al. (2021) SurgiCal Obesity Treatment Study (SCOTS): a prospective, observational cohort study on health and socioeconomic burden in treatment-seeking individuals with severe obesity in Scotland, UK. BMJ Open, 11(8), e046441. (doi: 10.1136/bmjopen-2020-046441) (PMID:34446484)

Darmon, A. et al. (2021) Prevalence, incidence and prognostic implications of Left Bundle Branch Block in patients with chronic coronary syndromes (From the CLARIFY Registry). American Journal of Cardiology, 150, pp. 40-46. (doi: 10.1016/j.amjcard.2021.03.047) (PMID:34011435)

Ford, I. et al. (2021) Simple risk models to predict cardiovascular death in patients with stable coronary artery disease. European Heart Journal: Quality of Care and Clinical Outcomes, 7(3), pp. 287-294. (doi: 10.1093/ehjqcco/qcz070) (PMID:31922541)

Jhund, P. S. et al. (2021) Heart failure hospitalization in adults receiving maintenance hemodialysis and effect of intravenous iron therapy: A report from PIVOTAL. JACC: Heart Failure, 9(7), pp. 518-527. (doi: 10.1016/j.jchf.2021.04.005) (PMID:34119470)

Greenwood, S. A. et al. (2021) Exercise programme to improve quality of life for patients with end-stage kidney disease receiving haemodialysis: the PEDAL RCT. Health Technology Assessment, 25(40), (doi: 10.3310/hta25400) (PMID:34156335)

Timmons, J. G. et al. (2021) Metformin and carotid intima-media thickness in never-smokers with type 1 diabetes: the REMOVAL trial. Diabetes, Obesity and Metabolism, 23(6), pp. 1371-1378. (doi: 10.1111/dom.14350) (PMID:33591613)

Schunk, S. J. et al. (2021) Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality. European Heart Journal, 42(18), pp. 1742-1756. (doi: 10.1093/eurheartj/ehab107) (PMID:33748830)

Greenwood, S. A. et al. (2021) The PrEscription of intraDialytic exercise to improve quAlity of Life in patients with chronic kidney disease trial: study design and baseline data for a multicentre randomized controlled trial. Clinical Kidney Journal, 14(5), pp. 1345-1355. (doi: 10.1093/ckj/sfaa107) (PMID:33959264) (PMCID:PMC8087141)

Bos, M. M. et al. (2021) Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses. BMC Medicine, 19(1), p. 69. (doi: 10.1186/s12916-021-01939-0) (PMID:33731105) (PMCID:PMC7971964)

Lee, M. M.Y. et al. (2021) Invasive versus medically managed acute coronary syndromes with prior bypass (CABG-ACS): insights into the registry versus randomised trial populations. Open Heart, 8(1), e001453. (doi: 10.1136/openhrt-2020-001453) (PMID:33637568) (PMCID:PMC7919592)

Jensen, M. et al. (2021) Polypharmacy, functional outcome, and treatment effect of intravenous alteplase for acute ischemic stroke. European Journal of Neurology, 28(2), pp. 532-539. (doi: 10.1111/ene.14566) (PMID:33015924)

Maznyczka, A. M. et al. (2021) Effect of coronary flow on intracoronary alteplase: a prespecified analysis from a randomised trial. Heart, 107(4), pp. 299-312. (doi: 10.1136/heartjnl-2020-317828) (PMID:33436493)

Lagou, V. et al. (2021) Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nature Communications, 12, 24. (doi: 10.1038/s41467-020-19366-9) (PMID:33402679) (PMCID:PMC7785747)

Darmon, A. et al. (2021) Use of risk scores to identify lower and higher risk subsets among COMPASS-eligible patients with chronic coronary syndromes. Insights from the CLARIFY registry. Clinical Cardiology, 44(1), pp. 58-65. (doi: 10.1002/clc.23505) (PMID:33274779)

MacDonald, T. M., Nuki, G., Robertson, M., Ford, I. and Mackenzie, I. S. (2021) Cardiovascular safety of febuxostat - Authors' reply. Lancet, 398(10304), pp. 955-956. (doi: 10.1016/S0140-6736(21)01383-0) (PMID:34509228)

2020

Surendran, P. et al. (2020) Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics, 52(12), pp. 1314-1332. (doi: 10.1038/s41588-020-00713-x) (PMID:33230300) (PMCID:PMC7610439)

Mackenzie, I. S. et al. (2020) Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial. Lancet, 396(10264), pp. 1745-1757. (doi: 10.1016/S0140-6736(20)32234-0) (PMID:33181081)

Frey, B. M. et al. (2020) Safety and efficacy of intravenous thrombolysis in stroke patients on prior antiplatelet therapy in the WAKE-UP trial. Neurological Research and Practice, 2, 40. (doi: 10.1186/s42466-020-00087-9) (PMID:33324940) (PMCID:PMC7678217)

McCartney, P. J. et al. (2020) Low-dose intracoronary alteplase during primary percutaneous coronary intervention in patients with acute myocardial infarction: the T-TIME three-arm RCT. Efficacy and Mechanism Evaluation, 7(5), (doi: 10.3310/eme07050) (PMID:33175484)

Robertson, C., Pan, J., Kavanagh, K., Ford, I. , McCowan, C. , Bennie, M., Marwick, C. and Leanord, A. (2020) Cost burden of Clostridioides difficile infection to the health service: a retrospective cohort study in Scotland. Journal of Hospital Infection, 106(3), pp. 554-561. (doi: 10.1016/j.jhin.2020.07.019) (PMID:32717202)

Stähli, B. E. et al. (2020) Rationale and design of the MULTISTARS AMI Trial: a randomized comparison of immediate versus staged complete revascularization in patients with ST-segment elevation myocardial infarction and multivessel disease. American Heart Journal, 228, pp. 98-108. (doi: 10.1016/j.ahj.2020.07.016) (PMID:32871329)

Witham, M. D. et al. (2020) Vitamin K supplementation to improve vascular stiffness in chronic kidney disease: the K4Kidneys randomised controlled trial. Journal of the American Society of Nephrology, 31(10), pp. 2434-2445. (doi: 10.1681/ASN.2020020225) (PMID:32817311)

Chen, S. et al. (2020) Associations of cytomegalovirus infection with all-cause and cardiovascular mortality in multiple observational cohort studies of older adults. Journal of Infectious Diseases, (doi: 10.1093/infdis/jiaa480) (PMID:32909605)

Barow, E. et al. (2020) Clinical characteristics and outcome of patients with lacunar infarcts and concurrent embolic ischemic lesions. Clinical Neuroradiology, 30, pp. 511-516. (doi: 10.1007/s00062-019-00800-5) (PMID:1161343)

Ferrari, R., Ford, I. , Fox, K., Challeton, J. P., Correges, A., Tendera, M., Widimský, P. and Danchin, N. (2020) Efficacy and safety of trimetazidine after percutaneous coronary intervention (ATPCI): a randomised, double-blind, placebo-controlled trial. Lancet, 396(10254), pp. 830-838. (doi: 10.1016/S0140-6736(20)31790-6) (PMID:32877651)

Bulluck, H. et al. (2020) Redefining adverse and reverse left ventricular remodeling by cardiovascular magnetic resonance following ST-segment elevation myocardial infarction and their implications on long-term prognosis. Circulation: Cardiovascular Imaging, 13(7), e009937. (doi: 10.1161/CIRCIMAGING.119.009937) (PMID:32689822)

Bivard, A. et al. (2020) Comparing mismatch strategies for patients being considered for ischemic stroke tenecteplase trials. International Journal of Stroke, 15(5), pp. 507-515. (doi: 10.1177/1747493019884529) (PMID:31684841)

Macdougall, I. C. and Ford, I. (2020) Authors' reply. Journal of the American Society of Nephrology, 31(7), p. 1654. (doi: 10.1681/ASN.2020050624) (PMID:32606033)

de Montmollin, M. et al. (2020) L-thyroxine therapy for older adults with subclinical hypothyroidism and hypothyroid symptoms: secondary analysis of a randomized trial. Annals of Internal Medicine, 172(11), pp. 709-716. (doi: 10.7326/M19-3193) (PMID:32365355)

Ntalla, I. et al. (2020) Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nature Communications, 11, 2542. (doi: 10.1038/s41467-020-15706-x) (PMID:32439900) (PMCID:PMC7242331)

Parma, Z., Jasilek, A., Greenlaw, N. , Ferrari, R., Ford, I. , Fox, K., Tardif, J.‐C., Tendera, M. and Steg, P. G. (2020) Incident heart failure in outpatients with chronic coronary syndrome: results from the international prospective CLARIFY registry. European Journal of Heart Failure, 22(5), pp. 804-812. (doi: 10.1002/ejhf.1827) (PMID:32297414)

Guthrie, G., Poulter, N., Macdonald, T., Ford, I. , Mackenzie, I., Findlay, E., Williams, B., Brown, M., Lang, C. and Webb, D. (2020) Chronotherapy in hypertension: the devil is in the details. European Heart Journal, 41(16), pp. 1606-1607. (doi: 10.1093/eurheartj/ehaa265) (PMID:32306034)

Raal, F. J. et al. (2020) Inclisiran for the treatment of heterozygous familial hypercholesterolemia. New England Journal of Medicine, 382(16), pp. 1520-1530. (doi: 10.1056/NEJMoa1913805) (PMID:32197277)

Ray, K. K. et al. (2020) Two phase 3 trials of inclisiran in patients with elevated LDL cholesterol. New England Journal of Medicine, 382(16), pp. 1507-1519. (doi: 10.1056/NEJMoa1912387) (PMID:32187462)

Macdougall, I. C. et al. (2020) Intravenous iron dosing and infection risk in patients on hemodialysis: a prespecified secondary analysis of the PIVOTAL trial. Journal of the American Society of Nephrology, 31(4), 2019090972. (doi: 10.1681/ASN.2019090972) (PMID:32253271)

Biscaglia, S. et al. (2020) Relationship between physical activity and long-term outcomes in patients with stable coronary artery disease. European Journal of Preventive Cardiology, 27(4), pp. 426-436. (doi: 10.1177/2047487319871217) (PMID:31558054)

Maznyczka, A. M. et al. (2020) One-year outcomes after low-dose intracoronary alteplase during primary percutaneous coronary intervention. The T-TIME randomized trial. Circulation: Cardiovascular Interventions, 13(2), e008855. (doi: 10.1161/CIRCINTERVENTIONS.119.008855) (PMID:32069113)

Sorbets, E. et al. (2020) Long-term outcomes of chronic coronary syndrome worldwide: insights from the international CLARIFY registry. European Heart Journal, 41(3), pp. 347-356. (doi: 10.1093/eurheartj/ehz660) (PMID:31504434) (PMCID:PMC6964227)

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Zijlstra, L.E., van Velzen, D.M., Simsek, S., Mooijaart, S.P., van Buren, M., Stott J, D.J. , Ford, I. , Jukema, J. and Trompet, S. (2020) The kidney, subclinical thyroid disease and cardiovascular outcomes in older patients. Endocrine Connections, 9(1), pp. 55-62. (doi: 10.1530/EC-19-0502) (PMID:31846431) (PMCID:PMC6993270)

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2019

Vidal-Petiot, E. et al. (2019) Chronic kidney disease has a graded association with death and cardiovascular outcomes in stable coronary artery disease: an analysis of 21,911 patients from the CLARIFY registry. Journal of Clinical Medicine, 9(1), 4. (doi: 10.3390/jcm9010004)

de las Fuentes, L. et al. (2019) Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry. Pharmacogenomics Journal, 20(3), pp. 482-493. (doi: 10.1038/s41397-019-0132-y) (PMID:31806883) (PMCID:PMC7260079)

Bouabdallaoui, N., O'Meara, E., Bernier, V., Komajda, M., Swedberg, K., Tavazzi, L., Borer, J. S., Bohm, M., Ford, I. and Tardif, J.‐C. (2019) Beneficial effects of ivabradine in patients with heart failure, low ejection fraction, and heart rate above 77 b.p.m. ESC Heart Failure, 6(6), pp. 1199-1207. (doi: 10.1002/ehf2.12513) (PMID:31591826) (PMCID:PMC6989297)

Irvin, M. R. et al. (2019) Genome wide association study of apparent treatment resistant hypertension in the CHARGE consortium: the CHARGE pharmacogenetics working group. American Journal of Hypertension, 32(12), pp. 1146-1153. (doi: 10.1093/ajh/hpz150) (PMID:31545351)

Rostamian, S., de Haan, S., van der Grond, J., van Buchem, M. A., Ford, I. , Jukema, J. W. and Sabayan, B. (2019) Cognitive function in dementia-free subjects and survival in old Age: The PROSPER study. American Journal of Medicine, 132(12), 1466-1474.e4. (doi: 10.1016/j.amjmed.2019.06.001) (PMID:31228412)

Mooijaart, S. P. et al. (2019) Association between levothyroxine treatment and thyroid-related symptoms among adults aged 80 years and older with subclinical hypothyroidism. JAMA: Journal of the American Medical Association, 322(20), pp. 1977-1986. (doi: 10.1001/jama.2019.17274) (PMID:31664429)

Schlemm, L. et al. (2019) Current smoking does not modify the treatment effect of intravenous thrombolysis in acute ischemic stroke patients—a post-hoc analysis of the WAKE-UP trial. Frontiers in Neurology, 10, 1239. (doi: 10.3389/fneur.2019.01239) (PMID:31824412) (PMCID:PMC6883001)

El-Tawil, S., Mair, G., Huang, X., Sakka, E., Palmer, J., Ford, I. , Kalra, L., Wardlaw, J. and Muir, K. W. (2019) Observer agreement on CT Perfusion imaging in acute ischemic stroke. Stroke, 50(11), pp. 3108-3114. (doi: 10.1161/STROKEAHA.119.026238) (PMID:31928512) (PMCID:PMC6824508)

Schmidt, A. F. et al. (2019) Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9. BMC Cardiovascular Disorders, 19, 240. (doi: 10.1186/s12872-019-1187-z) (PMID:31664920) (PMCID:PMC6820948)

Kaptoge, S. et al. (2019) Longer-term efficiency and safety of increasing the frequency of whole blood donation (INTERVAL): extension study of a randomised trial of 20 757 blood donors. Lancet Haematology, 6(10), e510-e520. (doi: 10.1016/S2352-3026(19)30106-1) (PMID:31383583) (PMCID:PMC7029279)

Kaptoge, S. et al. (2019) World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions. Lancet Global Health, 7(10), e1332-e1345. (doi: 10.1016/S2214-109X(19)30318-3) (PMID:31488387)

Galinovic, I. et al. (2019) Post-hoc analysis of outcome of intravenous thrombolysis in infarcts of infratentorial localization in the WAKE-UP trial. Frontiers in Neurology, 10, 983. (doi: 10.3389/fneur.2019.00983) (PMID:31572293) (PMCID:PMC6749039)

Lee, M. M.Y. et al. (2019) Invasive versus medical management in patients with prior coronary artery bypass surgery with a non-ST segment elevation acute coronary syndrome: a pilot randomized controlled trial. Circulation: Cardiovascular Interventions, 12(8), e007830. (doi: 10.1161/CIRCINTERVENTIONS.119.007830) (PMID:31362541)

Gandhi, S. et al. (2019) Living alone and cardiovascular disease outcomes. Heart, 105(14), pp. 1087-1095. (doi: 10.1136/heartjnl-2018-313844) (PMID:30792241)

Markus, H. S. et al. (2019) Stenting for symptomatic vertebral artery stenosis: a preplanned pooled individual patient data analysis. Lancet Neurology, 18(7), pp. 666-673. (doi: 10.1016/S1474-4422(19)30149-8) (PMID:31130429)

Malik, R. et al. (2019) Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics, (doi: 10.1038/s41588-019-0449-0) (PMID:31160810)

Turcot, V. et al. (2019) Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics, (doi: 10.1038/s41588-019-0447-2) (PMID:31160809)

Brazel, D. M. et al. (2019) Exome chip meta-analysis fine maps causal variants and elucidates the genetic architecture of rare coding variants in smoking and alcohol use. Biological Psychiatry, 85(11), pp. 946-955. (doi: 10.1016/j.biopsych.2018.11.024) (PMID:30679032)

Cook, J. A., Fergusson, D. A., Ford, I. , Gonen, M., Kimmelman, J., Korn, E. L. and Begg, C. B. (2019) There is still a place for significance testing in clinical trials. Clinical Trials, 16(3), pp. 223-224. (doi: 10.1177/1740774519846504) (PMID:31068002)

Barrow, E. et al. (2019) Functional outcome of intravenous thrombolysis in patients with lacunar infarcts in the WAKE-UP trial. JAMA Neurology, 76(6), pp. 641-649. (doi: 10.1001/jamaneurol.2019.0351) (PMID:30907934)

Haig, C. et al. (2019) Current smoking and prognosis after acute ST-segment elevation myocardial infarction: new pathophysiological insights. JACC: Cardiovascular Imaging, 12(6), pp. 993-1003. (doi: 10.1016/j.jcmg.2018.05.022) (PMID:30031700) (PMCID:PMC6547246)

van Setten, J. et al. (2019) Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits. European Journal of Human Genetics, 27(6), pp. 952-962. (doi: 10.1038/s41431-018-0295-z) (PMID:30679814) (PMCID:PMC6777533)

Lean, M. E.J. et al. (2019) Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial. Lancet Diabetes and Endocrinology, 7(5), pp. 344-355. (doi: 10.1016/S2213-8587(19)30068-3) (PMID:30852132)

Sorbets, E. et al. (2019) β-blockers, calcium antagonists, and mortality in stable coronary artery disease: an international cohort study. European Heart Journal, 40, pp. 1399-1407. (doi: 10.1093/eurheartj/ehy811) (PMID:30590529) (PMCID:PMC6503455)

Parma, Z., Young, R. , Roleder, T., Marona, M., Ford, I. , Tendera, M., Steg, P. G. and Stępińska, J. (2019) Management strategies and 5-year outcomes in Polish patients with stable coronary artery disease versus other European countries: data from the CLARIFY registry. Polish Archives of Internal Medicine, 129(5), pp. 327-334. (doi: 10.20452/pamw.14789) (PMID:30951032)

Ferrari, R., Ford, I. , Fox, K., Marzilli, M., Tendera, M., Widimský, P., Challeton, J.-P. and Danchin, N. (2019) A randomized, double-blind, placebo-controlled trial to assess the efficAcy and safety of Trimetazidine in patients with angina pectoris having been treated by percutaneous coronary intervention (ATPCI study): rationale, design, and baseline characteristics. American Heart Journal, 210, pp. 98-107. (doi: 10.1016/j.ahj.2018.12.015) (PMID:30771737)

Maznyczka, A. M. et al. (2019) Sex-based associations with microvascular injury and outcomes after ST-segment elevation myocardial infarction. Open Heart, 6(1), e000979. (doi: 10.1136/openhrt-2018-000979) (PMID:31168381) (PMCID:PMC6519583)

Patel, R. S. et al. (2019) Association of chromosome 9p21 with subsequent coronary heart disease events: a GENUIS-CHD study of individual participant data. Circulation: Genomic and Precision Medicine, 12(4), e002471. (doi: 10.1161/CIRCGEN.119.002471) (PMID:30897348)

Patel, R. et al. (2019) Subsequent event risk in individuals with established coronary heart disease: design and rationale of the GENIUS-CHD Consortium. Circulation: Genomic and Precision Medicine, (doi: 10.1161/CIRCGEN.119.002470) (PMID:30896328)

Hoshino, T. et al. (2019) Non-cardioembolic stroke/transient ischaemic attack in Asians and non-Asians: A post-hoc analysis of the PERFORM study. European Stroke Journal, 4(1), pp. 65-74. (doi: 10.1177/2396987318797245) (PMID:31165096) (PMCID:PMC6533862)

Picard, F., Bhatt, D. L., Ducrocq, G., Elbez, Y., Ferrari, R., Ford, I. , Tardif, J. C., Tendera, M., Fox, K. M. and Steg, P. G. (2019) Generalizability of the REDUCE-IT trial in patients with stable coronary artery disease. Journal of the American College of Cardiology, 73(11), pp. 1362-1364. (doi: 10.1016/j.jacc.2019.01.016) (PMID:30819552)

Larsson, S. C. et al. (2019) Serum magnesium and calcium levels in relation to ischemic stroke. Neurology, 92(9), e944-e950. (doi: 10.1212/WNL.0000000000007001) (PMID:30804065) (PMCID:PMC6404465)

Pennells, L. et al. (2019) Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies. European Heart Journal, 40(7), pp. 621-631. (doi: 10.1093/eurheartj/ehy653) (PMID:30476079) (PMCID:PMC6374687)

Armitage, J. et al. (2019) Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials. Lancet, 393(10170), pp. 407-415. (doi: 10.1016/S0140-6736(18)31942-1) (PMID:30712900) (PMCID:PMC6429627)

Macdougall, I. C. et al. (2019) Intravenous iron in patients undergoing maintenance hemodialysis. New England Journal of Medicine, 380(5), pp. 447-458. (doi: 10.1056/NEJMoa1810742) (PMID:30365356)

Macdougall, I. C. et al. (2019) Correction: Intravenous iron in patients undergoing maintenance hemodialysis. New England Journal of Medicine, 380(5), p. 502. (doi: 10.1056/NEJMx180044) (PMID:30641026)

Chauhan, G. et al. (2019) Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. Neurology, 92(5), e486-e503. (doi: 10.1212/WNL.0000000000006851) (PMID:30651383) (PMCID:PMC6369905)

Adlam, D. et al. (2019) Association of the PHACTR1/EDN1 genetic locus with spontaneous coronary artery dissection. Journal of the American College of Cardiology, 73(1), pp. 58-66. (doi: 10.1016/j.jacc.2018.09.085) (PMID:30621952)

Mahinrad, S. et al. (2019) Spatial QRS-T angle and cognitive decline in older subjects. Journal of Alzheimer's Disease, 67(1), pp. 279-289. (doi: 10.3233/JAD-180633) (PMID:30584139)

McCartney, P. J. et al. (2019) Effect of low-dose intracoronary alteplase during primary percutaneous coronary intervention on microvascular obstruction in patients with acute myocardial infarction: a randomized clinical trial. JAMA: Journal of the American Medical Association, 321(1), pp. 56-68. (doi: 10.1001/jama.2018.19802) (PMID:30620371) (PMCID:PMC6583564)

Singh, A. et al. (2019) Symptom onset in aortic stenosis: relation to sex differences in left ventricular remodelling. JACC: Cardiovascular Imaging, 12(1), pp. 96-105. (doi: 10.1016/j.jcmg.2017.09.019) (PMID:29248646)

Macdougall, I. and Ford, I. (2019) Intravenous Iron and Maintenance Hemodialysis. New England Journal of Medicine, 380(24), e46. (doi: 10.1056/NEJMc1902945) (PMID:31189050)

2018

Pulit, S. L. et al. (2018) Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes. Neurology Genetics, 4(6), e293. (doi: 10.1212/NXG.0000000000000293) (PMID:30584597) (PMCID:PMC6283455)

Vidal-Petiot, E. et al. (2018) Potential impact of the 2017 ACC/AHA guideline on high blood pressure in normotensive patients with stable coronary artery disease: insights from the CLARIFY registry. European Heart Journal, 39(43), pp. 3855-3863. (doi: 10.1093/eurheartj/ehy488) (PMID:30124796) (PMCID:PMC6234847)

Ligthart, S. et al. (2018) Genome analyses of >200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders. American Journal of Human Genetics, 103(5), pp. 691-706. (doi: 10.1016/j.ajhg.2018.09.009) (PMID:30388399) (PMCID:PMC6218410)

Mahajan, A. et al. (2018) Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics, 50, pp. 1505-1513. (doi: 10.1038/s41588-018-0241-6) (PMID:30297969)

Sliz, E. et al. (2018) Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment. Circulation, 138(22), pp. 2499-2512. (doi: 10.1161/CIRCULATIONAHA.118.034942) (PMID:30524137)

Teumer, A. et al. (2018) Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation. Nature Communications, 9, 4455. (doi: 10.1038/s41467-018-06356-1) (PMID:30367059) (PMCID:PMC6203810)

Feller, M. et al. (2018) Association of thyroid hormone therapy with quality of life and thyroid-related symptoms in patients with subclinical hypothyroidism: a systematic review and meta-analysis. JAMA: Journal of the American Medical Association, 320(13), pp. 1349-1359. (doi: 10.1001/jama.2018.13770)

Lindsay, C. R. et al. (2018) Somatic cancer genetics in the UK: real-world data from phase I of the Cancer Research UK Stratified Medicine Programme. ESMO Open, 3(6), e000408. (doi: 10.1136/esmoopen-2018-000408) (PMID:30233821) (PMCID:PMC6135448)

Du Puy, R.S. et al. (2018) Study protocol: a randomised controlled trial on the clinical effects of levothyroxine treatment for subclinical hypothyroidism in people aged 80 years and over. BMC Endocrine Disorders, 18, 67. (doi: 10.1186/s12902-018-0285-8) (PMID:30231866) (PMCID:PMC6146605)

Carberry, J. et al. (2018) Persistent iron within the infarct core after ST-segment elevation myocardial infarction: implications for left ventricular remodeling and health outcomes. JACC: Cardiovascular Imaging, 11(9), pp. 1248-1256. (doi: 10.1016/j.jcmg.2017.08.027) (PMID:29153575) (PMCID:PMC6130225)

Carrick, D. et al. (2018) Hypertension, microvascular pathology and prognosis after an acute myocardial infarction. Hypertension, 72(3), pp. 720-730. (doi: 10.1161/HYPERTENSIONAHA.117.10786) (PMID:30012869) (PMCID:PMC6080885)

Komajda, M., Böhm, M., Borer, J. S., Ford, I. , Tavazzi, L., Pannaux, M. and Swedberg, K. (2018) Incremental benefit of drug therapies for chronic heart failure with reduced ejection fraction: a network meta-analysis. European Journal of Heart Failure, 20(9), pp. 1315-1322. (doi: 10.1002/ejhf.1234) (PMID:29806165)

Roselli, C. et al. (2018) Multi-ethnic genome-wide association study for atrial fibrillation. Nature Genetics, 50(9), pp. 1225-1233. (doi: 10.1038/s41588-018-0133-9) (PMID:29892015)

van der Laan, S. W. et al. (2018) Genetic susceptibility loci for cardiovascular disease and their impact on atherosclerotic plaques. Circulation: Genomic and Precision Medicine, 11(9), e002115. (doi: 10.1161/CIRCGEN.118.002115)

Thomalla, G. et al. (2018) MRI-guided thrombolysis for stroke with unknown time of onset. New England Journal of Medicine, 379(7), pp. 611-622. (doi: 10.1056/NEJMoa1804355) (PMID:29766770)

Raman, S. R. et al. (2018) Leveraging electronic health records for clinical research. American Heart Journal, 202, pp. 13-19. (doi: 10.1016/j.ahj.2018.04.015) (PMID:29802975)

Yew, S. N. et al. (2018) Coronary thermodilution waveforms after acute reperfused ST‐segment–elevation myocardial infarction: relation to microvascular obstruction and prognosis. Journal of the American Heart Association, 7(15), e008957. (doi: 10.1161/JAHA.118.008957) (PMID:30371237) (PMCID:PMC6201480)

Burgess, S. et al. (2018) Association of LPA variants with risk of coronary disease and the implications for lipoprotein(a)-lowering therapies. JAMA Cardiology, 3(7), pp. 619-627. (doi: 10.1001/jamacardio.2018.1470) (PMID:29926099)

Burton, J. K. , Papworth, R., Haig, C. , McCowan, C. , Ford, I. , Stott, D. J. and Quinn, T. J. (2018) Statin use is not associated with future long-term care admission - extended follow-up of two randomised controlled trials. Drugs and Aging, 35(7), pp. 657-663. (doi: 10.1007/s40266-018-0560-4) (PMID:29916140)

Williams, B. et al. (2018) Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies. Lancet Diabetes and Endocrinology, 6(6), pp. 464-475. (doi: 10.1016/S2213-8587(18)30071-8) (PMID:29655877) (PMCID:PMC5966620)

Davies, G. et al. (2018) Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications, 9, 2098. (doi: 10.1038/s41467-018-04362-x) (PMID:29844566) (PMCID:PMC5974083)

Wood, A. M. et al. (2018) Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies. Lancet, 391(10129), pp. 1513-1523. (doi: 10.1016/S0140-6736(18)30134-X) (PMID:29676281)

Delles, C. et al. (2018) Nuclear magnetic resonance-based metabolomics identifies phenylalanine as a novel predictor of incident heart failure hospitalisation: results from PROSPER and FINRISK 1997. European Journal of Heart Failure, 20, pp. 663-673. (doi: 10.1002/ejhf.1076) (PMID:29226610) (PMCID:PMC5947152)

Malik, R. et al. (2018) Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics, 50(4), pp. 524-537. (doi: 10.1038/s41588-018-0058-3) (PMID:29531354) (PMCID:PMC5968830)

Seyerle, A. A. et al. (2018) Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology. Pharmacogenomics Journal, 18(2), pp. 215-226. (doi: 10.1038/tpj.2017.10) (PMID:28719597) (PMCID:PMC5773415)

Tayal, B. et al. (2018) Cardiac resynchronization therapy in patients with heart failure and narrow QRS complexes. Journal of the American College of Cardiology, 71(12), pp. 1325-1333. (doi: 10.1016/j.jacc.2018.01.042) (PMID:29566816)

Lee, M. M.Y. et al. (2018) Non-Invasive Versus Invasive Management in Patients With Prior Coronary Artery Bypass Surgery With a Non-ST Segment Elevation Acute Coronary Syndrome: Comparisons Between the Randomized Controlled Pilot Trial and Registry. ACC.18, Orlando, FL, USA, 10-12 Mar 2018. A45. (doi: 10.1016/S0735-1097(18)30586-2)

Kalra, P. R., Greenlaw, N. , Ford, I. , Steg, P. G. and Fox, K. M. (2018) The reply. American Journal of Medicine, 131(3), e129. (doi: 10.1016/j.amjmed.2017.09.019) (PMID:29454433)

Markus, H.S., Larsson, S.C., Kuker, S.C., Kuker, W., Schulz, U.G. and Ford, I. (2018) Stenting for symptomatic vertebral artery stenosis: The Vertebral Artery Ischaemia Stenting Trial. Journal of Vascular Surgery, 67(3), p. 986. (doi: 10.1016/j.jvs.2018.01.015)

Smit, R. A. J., Jukema, J. W., Postmus, I., Ford, I. , Slagboom, P. E., Heijmans, B. T., Le Cessie, S. and Trompet, S. (2018) Visit-to-visit lipid variability: clinical significance, effects of lipid-lowering treatment, and (pharmaco)genetics. Journal of Clinical Lipidology, 12(2), 266-276.e3. (doi: 10.1016/j.jacl.2018.01.001) (PMID:29422286)

Taylor, R. et al. (2018) Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort. Diabetologia, 61(3), pp. 589-598. (doi: 10.1007/s00125-017-4503-0) (PMID:29188339)

Lean, M. E.J. et al. (2018) Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet, 391(10120), pp. 541-551. (doi: 10.1016/S0140-6736(17)33102-1) (PMID:29221645)

Böhm, M., Komajda, M., Borer, J. S., Ford, I. , Maack, C., Tavazzi, L., Moyne, A. and Swedberg, K. (2018) Duration of chronic heart failure affects outcomes with preserved effects of heart rate reduction with ivabradine: findings from SHIFT. European Journal of Heart Failure, 20(2), pp. 373-381. (doi: 10.1002/ejhf.1021) (PMID:29027329)

Lee, M. M.Y. et al. (2018) Routine Non-invasive vs Invasive Management in Patients With Prior CABG With a NSTE-ACS: a Randomised Controlled Trial. British Cardiovascular Intervention Society Young Investigator Award Shortlisted Presentations, London, UK, 30 Nov 2017. A5.2-A6. (doi: 10.1136/heartjnl-2018-BCIS.9)

Thomalla, G. et al. (2018) Clinical characteristics of unknown symptom onset stroke patients with and without diffusion-weighted imaging and fluid-attenuated inversion recovery mismatch. International Journal of Stroke, 13(1), pp. 66-73. (doi: 10.1177/1747493017706245) (PMID:28425349)

Turcot, V. et al. (2018) Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics, 50(1), pp. 26-41. (doi: 10.1038/s41588-017-0011-x) (PMID:29273807) (PMCID:PMC5945951)

Macdougall, I. C. et al. (2018) Randomized trial comparing proactive, high-dose versus reactive, low-dose intravenous iron supplementation in hemodialysis (PIVOTAL): study design and baseline data. American Journal of Nephrology, 48(4), pp. 260-268. (doi: 10.1159/000493551) (PMID:30304714)

Vidal-Petiot, E., Greenlaw, N. , Ford, I. , Ferrari, R., Fox, K. M., Tardif, J.-C., Tendera, M., Parkhomenko, A., Bhatt, D. L. and Steg, P. G. (2018) Relationships between components of blood pressure and cardiovascular events in patients with stable coronary artery disease and hypertension. Hypertension, 71, pp. 168-176. (doi: 10.1161/HYPERTENSIONAHA.117.10204) (PMID:29084876)

2017

Carberry, J. et al. (2017) Persistence of infarct zone T2 hyperintensity at 6 months after acute ST-elevation myocardial infarction: incidence, pathophysiology and prognostic implications. Circulation: Cardiovascular Imaging, 10(12), e006586. (doi: 10.1161/CIRCIMAGING.117.006586) (PMID:29242240) (PMCID:PMC5753833)

Di Angelantonio, E. et al. (2017) Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors. Lancet, 390(10110), pp. 2360-2371. (doi: 10.1016/S0140-6736(17)31928-1) (PMID:28941948) (PMCID:PMC5714430)

Vallejo-Vaz, A. J., Robertson, M., Catapano, A. L., Watts, G. F., Kastelein, J. J., Packard, C. J. , Ford, I. and Ray, K. K. (2017) Low-density lipoprotein-cholesterol lowering for the primary prevention of cardiovascular disease among men with primary elevations of low-density lipoprotein-cholesterol levels of 190 mg/dL or above: analyses from the WOSCOPS (West of Scotland Coronary Prevention Study) 5-year randomized trial and 20-year observational follow-up. Circulation, 136(20), pp. 1878-1891. (doi: 10.1161/CIRCULATIONAHA.117.027966) (PMID:28877913)

MacDonald, T. M. et al. (2017) Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension: a double-blind randomized controlled trial. Journal of the American Heart Association, 6(11), e006986. (doi: 10.1161/JAHA.117.006986) (PMID:29151036) (PMCID:PMC5721778)

Joshi, P. K. et al. (2017) Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nature Communications, 8, 910. (doi: 10.1038/s41467-017-00934-5) (PMID:29030599) (PMCID:PMC5715013)

Packard, C. J. , Young, R. , Ross, K., Ford, I. , Ambegaonkar, B. M., Brudi, P. and McCowan, C. (2017) Modelling total coronary heart disease burden and long-term benefit of cholesterol lowering in middle aged men with and without a history of cardiovascular disease. European Heart Journal: Quality of Care and Clinical Outcomes, 3(4), pp. 281-288. (doi: 10.1093/ehjqcco/qcx012) (PMID:29044395)

Sorbets, E., Greenlaw, N. , Ferrari, R., Ford, I. , Fox, K. M., Tardif, J.-C., Tendera, M. and Steg, P. G. (2017) Rationale, design, and baseline characteristics of the CLARIFY registry of outpatients with stable coronary artery disease. Clinical Cardiology, 40(10), pp. 797-806. (doi: 10.1002/clc.22730) (PMID:28561986) (PMCID:PMC5697615)

Thomalla, G. et al. (2017) Effect of informed consent on patient characteristics in a stroke thrombolysis trial. Neurology, 89(13), pp. 1400-1407. (doi: 10.1212/WNL.0000000000004414) (PMID:28842449)

Markus, H. S., Larsson, S. C., Kuker, W., Schulz, U. G., Ford, I. , Rothwell, P. M. and Clifton, A. (2017) Stenting for symptomatic vertebral artery stenosis: The Vertebral Artery Ischaemia Stenting Trial. Neurology, 89(12), pp. 1229-1236. (doi: 10.1212/WNL.0000000000004385) (PMID:28835400) (PMCID:PMC5606920)

Weng, L.-C. et al. (2017) Genetic interactions with age, sex, body mass index, and hypertension in relation to atrial fibrillation: the AFGen consortium. Scientific Reports, 7, 11303. (doi: 10.1038/s41598-017-09396-7) (PMID:28900195) (PMCID:PMC5595875)

Willeit, P. et al. (2017) High-sensitivity cardiac troponin concentration and risk of first-ever cardiovascular outcomes: literature-based meta-analysis involving 154,052 participants. Journal of the American College of Cardiology, 70(5), pp. 558-568. (doi: 10.1016/j.jacc.2017.05.062) (PMID:28750699) (PMCID:PMC5527070)

El-Tawil, S., Wardlaw, J., Ford, I. , Mair, G., Robinson, T., Kalra, L. and Muir, K. W. (2017) Penumbra and re-canalization acute computed tomography in ischemic stroke evaluation: PRACTISE study protocol. International Journal of Stroke, 12(6), pp. 671-678. (doi: 10.1177/1747493017696099) (PMID:28730951)

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2016

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Gumley, A. et al. (2016) A parallel group randomised open blinded evaluation of Acceptance and Commitment Therapy for Depression After Psychosis: A Pilot Trial Protocol (ADAPT). Psychosis, 8(2), pp. 143-155. (doi: 10.1080/17522439.2015.1100669)

Leslie, W. S. et al. (2016) The Diabetes Remission Clinical Trial (DiRECT): protocol for a cluster randomised trial. BMC Family Practice, 17(1), (doi: 10.1186/s12875-016-0406-2) (PMID:26879684) (PMCID:PMC4754868)

2015

Böhm, M., Robertson, M., Ford, I. , Borer, J. S., Komajda, M., Kindermann, I., Maack, C., Lainscak, M., Swedberg, K. and Tavazzi, L. (2015) Influence of cardiovascular and noncardiovascular co-morbidities on outcomes and treatment effect of heart rate reduction With Ivabradine in stable heart failure (from the SHIFT Trial). American Journal of Cardiology, 116(12), pp. 1890-1897. (doi: 10.1016/j.amjcard.2015.09.029) (PMID:26508709)

Fox, K., Ford, I. , Steg, P. G., Tardif, J.-C., Tendera, M. and Ferrari, R. (2015) Bradycardia and atrial fibrillation in patients with stable coronary artery disease treated with ivabradine: an analysis from the SIGNIFY study. European Heart Journal, 36(46), pp. 3291-3296. (doi: 10.1093/eurheartj/ehv451) (PMID:26385957)

Komajda, M., Tavazzi, L., Francq, B., Böhm, M., Borer, J. S., Ford, I. and Swedberg, K. (2015) Efficacy and safety of ivabradine in patients with chronic systolic heart failure and diabetes: an analysis from the SHIFT trial. European Journal of Heart Failure, 17(12), pp. 1294-1301. (doi: 10.1002/ejhf.347) (PMID:26377342)

Packard, C. and Ford, I. (2015) Long-term follow-up of lipid-lowering trials. Current Opinion in Lipidology, 26(6), pp. 572-579. (doi: 10.1097/mol.0000000000000230) (PMID:26780010)

Williams, B. et al. (2015) Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. Lancet, 386(10008), pp. 2059-2068. (doi: 10.1016/S0140-6736(15)00257-3) (PMID:26414968) (PMCID:PMC4655321)

van Leeuwen, E. M. et al. (2015) Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C. npj Aging and Mechanisms of Disease, 1, 15011. (doi: 10.1038/npjamd.2015.11) (PMID:28721259) (PMCID:PMC5514988)

Hofer, E. et al. (2015) White matter lesion progression: genome-wide search for genetic influences. Stroke, 46(11), pp. 3048-3057. (doi: 10.1161/STROKEAHA.115.009252) (PMID:26451028)

Rogers, J. K., Kielhorn, A., Borer, J. S., Ford, I. and Pocock, S. J. (2015) Effect of ivabradine on numbers needed to treat for the prevention of recurrent hospitalizations in heart failure patients. Current Medical Research and Opinion, 31(10), pp. 1903-1909. (doi: 10.1185/03007995.2015.1080155) (PMID:26361063)

Hamill, V. et al. (2015) Repeated heart rate measurement and cardiovascular outcomes in left ventricular systolic dysfunction. American Journal of Medicine, 128(10), 1102-1108.e6. (doi: 10.1016/j.amjmed.2015.04.042) (PMID:26044936)

Nikpay, M. et al. (2015) A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease. Nature Genetics, 47(10), pp. 1121-1130. (doi: 10.1038/ng.3396) (PMID:26343387) (PMCID:PMC4589895)

Morris, R. W. et al. (2015) Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium: Table 1. BMJ Open, 5(8), e008808. (doi: 10.1136/bmjopen-2015-008808) (PMID:26264275) (PMCID:PMC4538266)

Steffel, J. et al. (2015) The effect of QRS duration on cardiac resynchronization therapy in patients with a narrow QRS complex: a subgroup analysis of the EchoCRT trial. European Heart Journal, 36(30), pp. 1983-1989. (doi: 10.1093/eurheartj/ehv242) (PMID:26009595)

Joshi, P. K. et al. (2015) Directional dominance on stature and cognition in diverse human populations. Nature, 523(7561), pp. 459-462. (doi: 10.1038/nature14618) (PMID:26131930)

Bocchi, E. A., Bohm, M., Borer, J.S., Ford, I. , Komajda, M., Swedberg, K. and Tavazzi, L. (2015) Effect of combining ivabradine and β-blockers: focus on the use of carvedilol in the SHIFT population. Cardiology, 131(4), pp. 218-224. (doi: 10.1159/000380812) (PMID:25968495)

Carrick, D. et al. (2015) Pathophysiology of LV remodeling in survivors of STEMI : inflammation, remote myocardium, and prognosis. JACC: Cardiovascular Imaging, 8(7), pp. 779-789. (doi: 10.1016/j.jcmg.2015.03.007) (PMID:26093923) (PMCID:PMC4509710)

Preiss, D. et al. (2015) The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials. European Heart Journal, 36(24), pp. 1536-1546. (doi: 10.1093/eurheartj/ehv072) (PMID:25802390) (PMCID:PMC4769322)

Böhm, M. et al. (2015) Twenty-four-hour heart rate lowering with ivabradine in chronic heart failure: insights from the SHIFT Holter substudy. European Journal of Heart Failure, 17(5), pp. 518-526. (doi: 10.1002/ejhf.258) (PMID:25801408)

Cholesterol Treatment Trialists’ (CTT) Collaboration, and , (2015) Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174 000 participants in 27 randomised trials. Lancet, 385(9976), pp. 1397-1405. (doi: 10.1016/S0140-6736(14)61368-4)

Ford, I. , Robertson, M., Komajda, M., Böhm, M., Borer, J. S., Tavazzi, L. and Swedberg, K. (2015) Top ten risk factors for morbidity and mortality in patients with chronic systolic heart failure and elevated heart rate: the SHIFT risk model. International Journal of Cardiology, 184, pp. 163-169. (doi: 10.1016/j.ijcard.2015.02.001) (PMID:25703424)

Huang, X., Cheripelli, B. K., Lloyd, S. M. , Kalladka, D., Moreton, F. C., Siddiqui, A., Ford, I. and Muir, K. W. (2015) Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis (ATTEST): phase 2 randomised clinical trial. Lancet Neurology, 14(4), pp. 368-376. (doi: 10.1016/S1474-4422(15)70017-7) (PMID:25726502)

Zimmermann, E. et al. (2015) Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults. Obesity Reviews, 16(4), pp. 327-340. (doi: 10.1111/obr.12263)

Borer, J. S., Böhm, M., Ford, I. , Komajda, M., Swedberg, K. and Tavazzi, L. (2015) Effect of ivabradine on early readmissions after hospitalization for worsening heart failure. JACC: Heart Failure, 3(3), pp. 268-269. (doi: 10.1016/j.jchf.2014.12.004) (PMID:25742766)

Campbell, R. T. et al. (2015) Palliative care needs in patients hospitalized with heart failure (PCHF) study: rationale and design. ESC Heart Failure, 2(1), pp. 25-36. (doi: 10.1002/ehf2.12027) (PMID:27347426) (PMCID:PMC4864752)

Ponikowski, P. et al. (2015) The impact of intravenous ferric carboxymaltose on renal function: an analysis of the FAIR-HF study. European Journal of Heart Failure, 17(3), pp. 329-339. (doi: 10.1002/ejhf.229) (PMID:25683972) (PMCID:PMC4413361)

Wijsman, L. W., de Craen, A. J.M., Muller, M., Sabayan, B., Stott, D. , Ford, I. , Trompet, S., Jukema, J. W., Westendorp, R. G.J. and Mooijaart, S. P. (2015) Blood pressure lowering medication, visit-to-visit blood pressure variability, and cognitive function in old age. American Journal of Hypertension, 29(3), pp. 311-318. (doi: 10.1093/ajh/hpv101) (PMID:26156873)

Shungin, D. et al. (2015) New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518(7538), pp. 187-196. (doi: 10.1038/nature14132) (PMID:25673412) (PMCID:PMC4338562)

Davies, G. et al. (2015) Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949). Molecular Psychiatry, 20(2), pp. 183-192. (doi: 10.1038/mp.2014.188) (PMID:25644384) (PMCID:PMC4356746)

Pers, T. H. et al. (2015) Biological interpretation of genome-wide association studies using predicted gene functions. Nature Communications, 6, p. 5890. (doi: 10.1038/ncomms6890) (PMID:25597830) (PMCID:PMC4420238)

Layland, J. et al. (2015) Fractional flow reserve vs. angiography in guiding management to optimize outcomes in non-ST-segment elevation myocardial infarction: the British Heart Foundation FAMOUS-NSTEMI randomized trial. European Heart Journal, 36(2), pp. 100-111. (doi: 10.1093/eurheartj/ehu338) (PMID:25179764) (PMCID:PMC4291317)

Swerdlow, D. I. et al. (2015) HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet, 385(9965), pp. 351-361. (doi: 10.1016/S0140-6736(14)61183-1) (PMID:25262344) (PMCID:PMC4322187)

Bis, J. C. et al. (2015) Drug-gene interactions of antihypertensive medications and risk of incident cardiovascular disease: a pharmacogenomics study from the CHARGE consortium. PLoS ONE, 10(10), e0140496. (doi: 10.1371/journal.pone.0140496) (PMID:26516778) (PMCID:PMC4627813)

Brown, M. J. et al. (2015) Comparison of single and combination diuretics on glucose tolerance (PATHWAY-3): protocol for a randomised double-blind trial in patients with essential hypertension. BMJ Open, 5(8), e008086. (doi: 10.1136/bmjopen-2015-008086) (PMID:26253567) (PMCID:PMC4539390)

Carrick, D. et al. (2015) Pathophysiology of myocardial remodeling in survivors of ST-elevation myocardial infarction revealed by native T1 mapping: inflammation, remote myocardium and prognostic significance. Journal of Cardiovascular Magnetic Resonance, 17(Sup 1), Q:52. (doi: 10.1186/1532-429X-17-S1-Q52) (PMCID:PMC4328295)

Carrick, D. et al. (2015) Prognostic significance of infarct core pathology in ST-elevation myocardial infarction survivors revealed by quantitative T2-weighted cardiac magnetic resonance. Journal of Cardiovascular Magnetic Resonance, 17(Sup 1), O54. (doi: 10.1186/1532-429X-17-S1-O54) (PMCID:PMC4328590)

Carrick, D. et al. (2015) Prognostic significance of quantitative measures of myocardial infarct pathology using native T1 mapping, in survivors of ST-elevation myocardial infarction. Journal of Cardiovascular Magnetic Resonance, 17(Sup 1), O53. (doi: 10.1186/1532-429X-17-S1-O53) (PMCID:PMC4328908)

Carrick, D. et al. (2015) Prognostic significance of infarct core pathology in ST-elevation myocardial infarction survivors revealed by non-contrast T1 mapping cardiac magnetic resonance. Journal of Cardiovascular Magnetic Resonance, 17(Sup 1), O26. (doi: 10.1186/1532-429X-17-S1-O26) (PMCID:PMC4328668)

Chaker, L. et al. (2015) Subclinical hypothyroidism and the risk of stroke events and fatal stroke: an individual participant data analysis. Journal of Clinical Endocrinology and Metabolism, 100(6), pp. 2181-2191. (doi: 10.1210/jc.2015-1438) (PMID:25856213)

Cook, J. A. et al. (2015) Specifying the target difference in the primary outcome for a randomised controlled trial: guidance for researchers. Trials, 16(1), 12. (doi: 10.1186/s13063-014-0526-8) (PMID:25928502) (PMCID:PMC4302137)

Fauchier, L., Greenlaw, N. , Ferrari, R., Ford, I. , Fox, K. M., Tardif, J.-C., Tendera, M. and Steg, P. G. (2015) Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry. PLoS ONE, 10(4), e0125164. (doi: 10.1371/journal.pone.0125164) (PMID:25915904) (PMCID:PMC4411156)

Galiè, N. et al. (2015) Initial use of ambrisentan plus tadalafil in pulmonary arterial hypertension. New England Journal of Medicine, 373(9), pp. 834-844. (doi: 10.1056/NEJMoa1413687) (PMID:26308684)

Locke, A. E. et al. (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature, 518(7538), pp. 197-206. (doi: 10.1038/nature14177) (PMID:25673413) (PMCID:PMC4382211)

Loeffen, R., Winckers, K., Ford, I. , Jukema, J. W., Robertson, M., Stott, D. J. , Spronk, H. M., ten Cate, H. and Lowe, G. (2015) Associations between thrombin generation and the risk of cardiovascular disease in elderly patients: results from the PROSPER study. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 70(8), pp. 982-988. (doi: 10.1093/gerona/glu228) (PMID:25540034)

Logue, J. et al. (2015) SurgiCal Obesity Treatment Study (SCOTS): protocol for a national prospective cohort study of patients undergoing bariatric surgery in Scotland. BMJ Open, 5(5), e008106. (doi: 10.1136/bmjopen-2015-008106) (PMID:26002692) (PMCID:PMC4442215)

MacDonald, T. M. et al. (2015) Monotherapy versus dual therapy for the initial treatment of hypertension (PATHWAY-1): a randomised double-blind controlled trial: figure 1. BMJ Open, 5(8), e007645. (doi: 10.1136/bmjopen-2015-007645) (PMID:26253566) (PMCID:PMC4539389)

Mccowan, C. , Thomson, E., Szmigielski, C. A., Kalra, D., Sullivan, F. M., Prokosch, H.-U., Dugas, M. and Ford, I. (2015) Using electronic health records to support clinical trials: a report on stakeholder engagement for EHR4CR. BioMed Research International, 2015, 707891. (doi: 10.1155/2015/707891) (PMID:26539523) (PMCID:PMC4619877)

Poortvliet, R. K.E. et al. (2015) Biological correlates of blood pressure variability in elderly at high risk of cardiovascular disease. American Journal of Hypertension, 28(4), pp. 469-479. (doi: 10.1093/ajh/hpu181) (PMID:25298176)

Templin, C. et al. (2015) Clinical features and outcomes of takotsubo (stress) cardiomyopathy. New England Journal of Medicine, 373(10), pp. 929-938. (doi: 10.1056/NEJMoa1406761) (PMID:26332547)

Williams, B. et al. (2015) Prevention And treatment of hypertension with algorithm-based therapy (PATHWAY) number 2: protocol for a randomised crossover trial to determine optimal treatment for drug-resistant hypertension. BMJ Open, 5(8), e008951. (doi: 10.1136/bmjopen-2015-008951) (PMID:26253568) (PMCID:PMC4538257)

2014

Mccowan, C. and Ford, I. (2014) Commentary on Vickers. Clinical Trials, 11(6), pp. 624-625. (doi: 10.1177/1740774514553483) (PMID:25389226)

Welsh, P. et al. (2014) Contrasting associations of insulin resistance with diabetes, cardiovascular disease and all-cause mortality in the elderly: PROSPER long-term follow-up. Diabetologia, 57(12), pp. 2513-2520. (doi: 10.1007/s00125-014-3383-9) (PMID:25264116)

Steg, P. G. et al. (2014) Prevalence of anginal symptoms and myocardial ischemia and their effect on clinical outcomes in outpatients with stable coronary artery disease: data from the international observational CLARIFY registry. JAMA Internal Medicine, 174(10), pp. 1651-1659. (doi: 10.1001/jamainternmed.2014.3773) (PMID:25110899)

Tendera, M. et al. (2014) Inadequate heart rate control despite widespread use of beta-blockers in outpatients with stable CAD: findings from the international prospective CLARIFY registry. International Journal of Cardiology, 176(1), pp. 119-124. (doi: 10.1016/j.ijcard.2014.06.052) (PMID:25042656)

Fox, K., Ford, I. , Steg, P. G., Tardif, J.-C., Tendera, M. and Ferrari, R. (2014) Ivabradine in Stable Coronary Artery Disease without Clinical Heart Failure. New England Journal of Medicine, 371(12), pp. 1091-1099. (doi: 10.1056/NEJMoa1406430) (PMID:25176136)

Dalby Kristensen, S. et al. (2014) 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: the joint task force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA). European Heart Journal, 35(35), pp. 2383-2431. (doi: 10.1093/eurheartj/ehu282) (PMID:25086026)

Anker, S.D. et al. (2014) The importance of patient-reported outcomes: a call for their comprehensive integration in cardiovascular clinical trials. European Heart Journal, 35(30), pp. 2001-2009. (doi: 10.1093/eurheartj/ehu205)

Jennings, C. G. et al. (2014) Up-titration of allopurinol in patients with gout. Seminars in Arthritis and Rheumatism, 44(1), pp. 25-30. (doi: 10.1016/j.semarthrit.2014.01.004)

Wijsman, L. W. et al. (2014) N-terminal pro-brain natriuretic peptide and cognitive decline in older adults at high cardiovascular risk. Annals of Neurology, 76(2), pp. 213-222. (doi: 10.1002/ana.24203)

Witham, M. D., Price, R. J.G., Struthers, A. D., Donnan, P. T., Messow, M. , McConnachie, A. , Ford, I. and McMurdo, M. E.T. (2014) Effect of vitamin D supplementation on orthostatic hypotension. Journal of Hypertension, 32(8), pp. 1693-1699. (doi: 10.1097/HJH.0000000000000223) (PMID:24879494)

Akao, H. et al. (2014) ABCA1 gene variation and heart disease risk reduction in the elderly during pravastatin treatment. Atherosclerosis, 235(1), pp. 176-181. (doi: 10.1016/j.atherosclerosis.2014.04.030) (PMID:24854628)

Komajda, M., Böhm, M., Borer, J. S., Ford, I. , Robertson, M., Manolis, A. J., Tavazzi, L. and Swedberg, K. (2014) Efficacy and safety of ivabradine in patients with chronic systolic heart failure according to blood pressure level in SHIFT. European Journal of Heart Failure, 16(7), pp. 810-816. (doi: 10.1002/ejhf.114)

Postmus, I. et al. (2014) In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study. Atherosclerosis, 235(1), pp. 58-64. (doi: 10.1016/j.atherosclerosis.2014.04.009)

Carrick, D. et al. (2014) A randomized trial of deferred stenting versus immediate stenting to prevent no- or slow-reflow in acute ST-segment elevation myocardial infarction (DEFER-STEMI). Journal of the American College of Cardiology, 63(20), pp. 2088-2098. (doi: 10.1016/j.jacc.2014.02.530) (PMID:24583294) (PMCID:PMC4029071)

Cooke, J. A. et al. (2014) Assessing methods to specify the target difference for a randomised controlled trial: DELTA (Difference ELicitation in TriAls) review. Health Technology Assessment, 18(28), v-vi, 1. (doi: 10.3310/hta18280)

Lubitz, S.A. et al. (2014) Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese. Journal of the American College of Cardiology, 63(12), pp. 1200-1210. (doi: 10.1016/j.jacc.2013.12.015)

Voors, A. A., van Veldhuisen, D. J., Robertson, M., Ford, I. , Borer, J. S., Bohm, M., Komajda, M., Swedberg, K. and Tavazzi, L. (2014) The effect of heart rate reduction with ivabradine on renal function in patients with chronic heart failure: an analysis from SHIFT. European Journal of Heart Failure, 16(4), pp. 426-434. (doi: 10.1002/ejhf.59)

Di Angelantonio, E. et al. (2014) Glycated hemoglobin measurement and prediction of cardiovascular disease. JAMA: Journal of the American Medical Association, 311(12), pp. 1225-1233. (doi: 10.1001/jama.2014.1873) (PMID:24668104) (PMCID:PMC4386007)

Virgini, V.S. et al. (2014) Subclinical thyroid dysfunction and functional capacity among elderly. Thyroid, 24(2), pp. 208-214. (doi: 10.1089/thy.2013.0071)

Borer, J.S., Böhm, M., Ford, I. , Robertson, M., Komajda, M., Tavazzi, L. and Swedberg, K. (2014) Efficacy and safety of ivabradine in patients with severe chronic systolic heart failure (from the SHIFT Study). American Journal of Cardiology, 113(3), pp. 497-503. (doi: 10.1016/j.amjcard.2013.10.033)

Preiss, D. , Lloyd, S. M. , Ford, I. , McMurray, J. J.V. , Holman, R. R., Welsh, P. , Fisher, M., Packard, C. J. and Sattar, N. (2014) Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial. Lancet Diabetes and Endocrinology, 2(2), pp. 116-124. (doi: 10.1016/S2213-8587(13)70152-9) (PMID:24622715)

Drewes, Y.M. et al. (2014) Homocysteine levels and treatment effect in the prospective study of pravastatin in the elderly at risk. Journal of the American Geriatrics Society, 62(2), pp. 213-221. (doi: 10.1111/jgs.12660)

Jennings, C., Flynn, R., Ford, I. , Nuki, G., MacDonald, T. and Mackenzie, I. (2014) Up-titration of allopurinol in patients with gout. Scottish Medical Journal, 59(1), E24-E25. (doi: 10.1177/0036933013518461)

Avery, C.L. et al. (2014) Drug–gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval. Pharmacogenomics Journal, 14(1), pp. 6-13. (doi: 10.1038/tpj.2013.4)

Baumert, J. et al. (2014) No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects. PLoS ONE, 9(12), e111156. (doi: 10.1371/journal.pone.0111156) (PMID:25551457) (PMCID:PMC4281156)

Bots, M.L., Ford, I. , Lloyd, S.M. , Laurent, S., Touboul, P.J. and Hennerici, M.G. (2014) Thromboxane prostaglandin receptor antagonist and carotid atherosclerosis progression in patients with cerebrovascular disease of ischemic origin: a randomized controlled trial. Stroke, 45(8), pp. 2348-2353. (doi: 10.1161/STROKEAHA.114.004775)

Deelen, J. et al. (2014) Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Human Molecular Genetics, 23(16), pp. 4420-4432. (doi: 10.1093/hmg/ddu139)

Ferrari, R., Ford, I. , Greenlaw, N. , Tardif, J.-C., Tendera, M., Abergel, H., Fox, K., Hu, D., Shalnova, S. and Steg, P. G. (2014) Geographical variations in the prevalence and management of cardiovascular risk factors in outpatients with CAD: data from the contemporary CLARIFY registry. European Journal of Preventive Cardiology, 22(8), pp. 1056-1065. (doi: 10.1177/2047487314547652) (PMID:25147344)

Holmes, M. V. et al. (2014) Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. British Medical Journal, 349, g4164. (doi: 10.1136/bmj.g4164) (PMID:25011450) (PMCID:PMC4091648)

Huang, J. et al. (2014) Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(5), pp. 1093-1101. (doi: 10.1161/ATVBAHA.113.302088)

Kalra, P. R. et al. (2014) Impact of chronic kidney disease on use of evidence-based therapy in stable coronary artery disease: a prospective analysis of 22,272 patients. PLoS ONE, 9(7), e102335. (doi: 10.1371/journal.pone.0102335) (PMID:25051258) (PMCID:PMC4106833)

Lewsey, J.D. et al. (2014) A cardiovascular disease policy model that predicts life expectancy taking into account socioeconomic deprivation. Heart, 101(3), pp. 201-208. (doi: 10.1136/heartjnl-2014-305637)

Lundby, A. et al. (2014) Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics. Nature Methods, 11(8), pp. 868-874. (doi: 10.1038/NMETH.2997)

MacDonald, T. M. et al. (2014) Protocol of the Febuxostat versus Allopurinol Streamlined Trial (FAST): a large prospective, randomised, open, blinded endpoint study comparing the cardiovascular safety of allopurinol and febuxostat in the management of symptomatic hyperuricaemia. BMJ Open, 4(7), e005354. (doi: 10.1136/bmjopen-2014-005354)

McConnachie, A. , Walker, A., Robertson, M., Marchbank, L., Peacock, J., Packard, C.J. , Cobbe, S.M. and Ford, I. (2014) Long-term impact on healthcare resource utilization of statin treatment, and its cost effectiveness in the primary prevention of cardiovascular disease: a record linkage study. European Heart Journal, 35(5), pp. 290-298. (doi: 10.1093/eurheartj/eht232)

Oei, L. et al. (2014) A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus. Journal of Medical Genetics, 51(2), pp. 122-131. (doi: 10.1136/jmedgenet-2013-102064)

Postmus, I. et al. (2014) Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nature Communications, 5, (doi: 10.1038/ncomms6068)

Sinner, M. F. et al. (2014) Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. Circulation, 130(15), pp. 1225-1235. (doi: 10.1161/CIRCULATIONAHA.114.009892)

Taylor, A. E. et al. (2014) Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. PLoS Genetics, 10(12), e1004799. (doi: 10.1371/journal.pgen.1004799)

Wood, A. R. et al. (2014) Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46(11), pp. 1173-1186. (doi: 10.1038/ng.3097) (PMID:25282103) (PMCID:PMC4250049)

2013

Tavazzi, L., Swedberg, K., Komajda, M., Böhm, M., Borer, J.S., Lainscak, M., Robertson, M. and Ford, I. (2013) Clinical profiles and outcomes in patients with chronic heart failure and chronic obstructive pulmonary disease: an efficacy and safety analysis of SHIFT study. International Journal of Cardiology, 170(2), pp. 182-188. (doi: 10.1016/j.ijcard.2013.10.068)

Cavanagh, J. et al. (2013) Socioeconomic status and the cerebellar grey matter volume. Data from a well-characterised population sample. Cerebellum, 12(6), pp. 882-891. (doi: 10.1007/s12311-013-0497-4)

Parsa, A. et al. (2013) Common variants in mendelian kidney disease genes and their association with renal function. Journal of the American Society of Nephrology, 24(12), pp. 2105-2117. (doi: 10.1681/ASN.2012100983)

Sabayan, B., van der Grond, J., Westendorp, R.G., Jukema, J.W., Ford, I. , Buckley, B.M., Sattar, N. , van Osch, M.J.P., van Buchem, M.A. and de Craen, A.J.M. (2013) Total cerebral blood flow and mortality in old age: a 12-year follow-up study. Neurology, 81(22), pp. 1922-1929. (doi: 10.1212/01.wnl.0000436618.48402.da)

Holmes, M.V. et al. (2013) Secretory phospholipase A2-IIA and cardiovascular disease. Journal of the American College of Cardiology, 62(21), pp. 1966-1976. (doi: 10.1016/j.jacc.2013.06.044)

Reil, J., Tardif, J., Ford, I. , Lloyd, S.M. , O'Meara, E., Komajda, M., Borer, J.S., Tavazzi, L., Swedberg, K. and Böhm, M. (2013) Selective heart rate reduction with ivabradine unloads the left ventricle in heart failure patients. Journal of the American College of Cardiology, 62(21), pp. 1977-1985. (doi: 10.1016/j.jacc.2013.07.027)

Layland, J. et al. (2013) TCT-82 Fractional Flow Reserve versus Angiography in Guiding Management to Optimize Outcomes in Non-ST Elevation Myocardial Infarction (FAMOUS - NSTEMI) Clinical Trial: Relationships Between FFR and Angiographic Stenosis Severity at Baseline. Journal of the American College of Cardiology, 62(18), B26. (doi: 10.1016/j.jacc.2013.08.817)

Layland, J. et al. (2013) TCT-84 Fractional Flow Reserve versus Angiography in Guiding Management to Optimize Outcomes in Non-ST Elevation Myocardial Infarction (FAMOUS - NSTEMI) Clinical Trial: Study Design and Baseline Characteristics of Randomized Participants. Journal of the American College of Cardiology, 62(18), B27. (doi: 10.1016/j.jacc.2013.08.1636)

Witham, M. D., Price, R. J.G., Struthers, A. D., Donnan, P. T., Messow, C.-M. , Ford, I. and McMurdo, M. E.T. (2013) Cholecalciferol treatment to reduce blood pressure in older patients with isolated systolic hypertension the VitDISH randomized controlled trial. JAMA Internal Medicine, 173(18), pp. 1672-1679. (doi: 10.1001/jamainternmed.2013.9043)

Ruschitzka, F. et al. (2013) Cardiac-Resynchronization Therapy in Heart Failure with a Narrow QRS Complex. New England Journal of Medicine, 369(15), pp. 1395-1405. (doi: 10.1056/NEJMoa1306687)

Fox, K., Bousser, M., Amarenco, P., Chamorro, A., Fisher, M., Ford, I. , Hennerici, M.G., Mattle, H.P. and Rothwell, P.M. (2013) Heart rate is a prognostic risk factor for myocardial infarction: a post hoc analysis in the PERFORM (Prevention of cerebrovascular and cardiovascular Events of ischemic origin with teRutroban in patients with a history of ischemic stroke or transient ischemic attack) study population. International Journal of Cardiology, 168(4), pp. 3500-3505. (doi: 10.1016/j.ijcard.2013.04.206)

Berry, C. et al. (2013) Fractional flow reserve versus angiography in guiding management to optimize outcomes in non–ST-elevation myocardial infarction (FAMOUS-NSTEMI): rationale and design of a randomized controlled clinical trial. American Heart Journal, 166(4), 662-668.e3. (doi: 10.1016/j.ahj.2013.07.011)

Fox, K., Ford, I. , Steg, P.G., Tardif, J., Tendera, M. and Ferrari, R. (2013) Rationale, design, and baseline characteristics of the Study assessInG the morbidity-mortality beNefits of the If inhibitor ivabradine in patients with coronarY artery disease (SIGNIFY trial): A randomized, double-blind, placebo-controlled trial of ivabradine in patients with stable coronary artery disease without clinical heart failure. American Heart Journal, 166(4), 654-661.e6. (doi: 10.1016/j.ahj.2013.06.024) (PMID:24093844)

Inglis, S.C. et al. (2013) Peripheral artery disease and outcomes after myocardial infarction: an individual-patient meta-analysis of 28,771 patients in CAPRICORN, EPEHESUS, OPTIMAAL and VALIANT. International Journal of Cardiology, 168(2), pp. 1094-1101. (doi: 10.1016/j.ijcard.2012.11.033)

Barry, S. J. E. , Dinnett, E., Kean, S., Gaw, A. and Ford, I. (2013) Are routinely collected NHS administrative records suitable for endpoint identification in clinical trials? Evidence from the West of Scotland coronary prevention study. PLoS ONE, 8(9), e75379. (doi: 10.1371/journal.pone.0075379) (PMID:24058681) (PMCID:PMC3772901)

Ferrari, R., Abergel, H., Ford, I. , Fox, K.M., Greenlaw, N. , Steg, P.G., Hu, D., Tendera, M. and Tardif, J. (2013) Gender- and age-related differences in clinical presentation and management of outpatients with stable coronary artery disease. International Journal of Cardiology, 167(6), pp. 2938-2943. (doi: 10.1016/j.ijcard.2012.08.013) (PMID:22985742)

Krishnadas, R. et al. (2013) Socioeconomic deprivation and cortical morphology: psychological, social, and biological determinants of ill health study. Psychosomatic Medicine, 75(7), pp. 616-623. (doi: 10.1097/PSY.0b013e3182a151a7)

Scott, R.A. et al. (2013) Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics, 44(9), pp. 991-1005. (doi: 10.1038/ng.2385)

Carrick, D. et al. (2013) A randomised controlled trial of deferred stenting versus immediate stenting to prevent no-reflow in acute ST-elevation myocardial infarction. Scottish Medical Journal, 58(3), e41-e41. (doi: 10.1177/0036933013495794)

Mooijaart, S.P., Sattar, N. , Trompet, S., Lucke, J., Stott, D.J. , Ford, I. , Jukema, J.W., Westendorp, R.G.J. and de Craen, A.J.M. (2013) Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study. Journal of Internal Medicine, 274(1), pp. 77-85. (doi: 10.1111/joim.12052)

Smith, B. H. et al. (2013) Cohort Profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness. International Journal of Epidemiology, 42(3), pp. 689-700. (doi: 10.1093/ije/dys084)

Berry, C. , Lloyd, S.M. , Wang, Y., MacDonald, A. and Ford, I. (2013) The changing course of aortic valve disease in Scotland: temporal trends in hospitalizations and mortality and prognostic importance of aortic stenosis. European Heart Journal, 34(21), pp. 1538-1547. (doi: 10.1093/eurheartj/ehs339)

Nanchen, D. et al. (2013) Resting heart rate and incident heart failure and cardiovascular mortality in older adults: role of inflammation and endothelial dysfunction: the PROSPER study. European Journal of Heart Failure, 15(5), pp. 581-588. (doi: 10.1093/eurjhf/hfs195)

Postmus, I., Trompet, S., de Craen, A.J.M., Buckley, B.M., Ford, I. , Stott, D.J. , Sattar, N. , Slagboom, P.E., Westendorp, R.G.J. and Jukema, J.W. (2013) PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population. Journal of Lipid Research, 54(2), pp. 561-566. (doi: 10.1194/jlr.P033969)

Böhm, M., Borer, J., Ford, I. , Gonzalez-Juanatey, J.R., Komajda, M., Lopez-Sendon, J., Reil, J.-C., Swedberg, K. and Tavazzi, L. (2013) Heart rate at baseline influences the effect of ivabradine on cardiovascular outcomes in chronic heart failure: analysis from the SHIFT study. Clinical Research in Cardiology, 102(1), pp. 11-22. (doi: 10.1007/s00392-012-0467-8)

Komajda, M., Bohm, M., Borer, J., Ford, I. , Krum, H., Tase, A., Tavazzi, L. and Swedberg, K. (2013) Influence of background treatment with mineralocorticoid receptor antagonists on ivabradine's effects in patients with chronic heart failure. European Journal of Heart Failure, 15(1), pp. 79-84. (doi: 10.1093/eurjhf/hfs127)

Abrahamsson, P., Swedberg, K., Borer, J.S., Bohm, M., Kober, L., Komajda, M., Lloyd, S.M. , Metra, M., Tavazzi, L. and Ford, I. (2013) Risk following hospitalization in stable chronic systolic heart failure. European Journal of Heart Failure, 15(8), pp. 885-891. (doi: 10.1093/eurjhf/hft032)

Filippatos, G. et al. (2013) Intravenous ferric carboxymaltose in iron-deficient chronic heart failure patients with and without anaemia: a subanalysis of the FAIR-HF trial. European Journal of Heart Failure, 15(11), pp. 1267-1276. (doi: 10.1093/eurjhf/hft099)

Fox, K. et al. (2013) Effect of ivabradine in patients with left-ventricular systolic dysfunction: a pooled analysis of individual patient data from the BEAUTIFUL and SHIFT trials. European Heart Journal, 34(29), pp. 2263-2270. (doi: 10.1093/eurheartj/eht101)

Jackson, C.E. et al. (2013) Spectral microvolt T-wave alternans testing has no prognostic value in patients recently hospitalized with decompensated heart failure. European Journal of Heart Failure, 15(11), pp. 1253-1261. (doi: 10.1093/eurjhf/hft085)

Jackson, C.E. et al. (2013) Feasibility/eligibility of T-wave alternans testing in patients with heart failure: should we rethink our current modus operandi?: reply. European Journal of Heart Failure, 14(6), pp. 676-677. (doi: 10.1093/eurjhf/hfs050)

Krishnadas, R. et al. (2013) Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: results from the psychological, social and biological determinants of ill health (pSoBid) study. NeuroImage: Clinical, 2(2013), pp. 646-657. (doi: 10.1016/j.nicl.2013.04.012)

Lloyd, S.M. et al. (2013) Long-term effects of statin treatment in elderly people: Extended follow-up of the PROspective study of Pravastatin in the elderly at risk (PROSPER). PLoS ONE, 8(9), e72642. (doi: 10.1371/journal.pone.0072642) (PMID:24023757) (PMCID:PMC3759378)

MacDonald, T.M., Mackenzie, I.S., Wei, L., Hawkey, C.J. and Ford, I. (2013) Methodology of a large prospective, randomised, open, blinded endpoint streamlined safety study of celecoxib versus traditional non-steroidal anti-inflammatory drugs in patients with osteoarthritis or rheumatoid arthritis: protocol of the standard care versus celecoxib outcome trial (SCOT). BMJ Open, 2013(3), e002295. (doi: 10.1136/bmjopen-2012-002295)

McCarthy, M.I. et al. (2013) A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. PLoS Genetics, 9(2), e1003266. (doi: 10.1371/journal.pgen.1003266)

Millar, K. et al. (2013) Personality, socio-economic status and inflammation: cross-sectional, population-based study. PLoS ONE, 8(3), e58256. (doi: 10.1371/journal.pone.0058256) (PMID:23516457) (PMCID:PMC3596406)

Reil, J.-C., Robertson, M., Ford, I. , Borer, J., Komajda, M., Swedberg, K., Tavazzi, L. and Bohm, M. (2013) Impact of left bundle branch block on heart rate and its relationship to treatment with ivabradine in chronic heart failure. European Journal of Heart Failure, 15(9), pp. 1044-1052. (doi: 10.1093/eurjhf/hft072)

Sabayan, B. et al. (2013) Association of visit-to-visit variability in blood pressure with cognitive function in old age: prospective cohort study. BMJ Open, 347, f4600. (doi: 10.1136/bmj.f4600)

Singh, A. et al. (2013) Rationale and design of the PRognostic Importance of MIcrovascular Dysfunction in asymptomatic patients with Aortic Stenosis (PRIMID-AS): a multicentre observational study with blinded investigations. BMJ Open, 3(12), e004348-e004348. (doi: 10.1136/bmjopen-2013-004348)

Stock, S.J., Ferguson, E., Duffy, A., Ford, I. , Chalmers, J. and Norman, J.E. (2013) Outcomes of induction of labour in women with previous caesarean delivery: a retrospective cohort study using a population database. PLoS ONE, 8(4), e60404. (doi: 10.1371/journal.pone.0060404) (PMID:23565242) (PMCID:PMC3615029)

Stuart, W.P., Hussey, K.K., Eifell, R.K.G., Drummond, R., Ford, I. and Welch, G.H. (2013) Using centrally held data to validate carotid surgery outcome data. Stroke, 44(6), pp. 1670-1675. (doi: 10.1161/STROKEAHA.111.000200)

Tavazzi, L., Swedberg, K., Komajda, M., Bohm, M., Borer, J.S., Lainscak, M. and Ford, I. (2013) Efficacy and safety of ivabradine in chronic heart failure across the age spectrum: insights from the SHIFT study. European Journal of Heart Failure, 15(11), pp. 1296-1303. (doi: 10.1093/eurjhf/hft102)

Verschuren, J.J.W. et al. (2013) Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data. PLoS ONE, 8(2), e56262. (doi: 10.1371/journal.pone.0056262) (PMID:23457540) (PMCID:PMC3574159)

Welsh, P. , Doolin, O., Willeit, P., Packard, C. , Macfarlane, P., Cobbe, S., Gudnason, V., Di Angelantonio, E., Ford, I. and Sattar, N. (2013) N-terminal pro-B-type natriuretic peptide and the prediction of primary cardiovascular events: results from 15-year follow-up of WOSCOPS. European Heart Journal, 34(6), pp. 443-450. (doi: 10.1093/eurheartj/ehs239)

Witham, M.D., Price, R.J.G., Struthers, A.D., Donnan, P.T., Messow, C. , Ford, I. and McMurdo, M.T. (2013) Cholecalciferol treatment to reduce blood pressure in older patients with isolated systolic hypertension. JAMA Internal Medicine, 173(18), pp. 1672-1679. (doi: 10.1001/jamainternmed.2013.9043)

2012

McLean, J. et al. (2012) Early life socioeconomic status, chronic physiological stress and hippocampal N-acetyl aspartate concentrations. Behavioural Brain Research, 235(2), pp. 225-230. (doi: 10.1016/j.bbr.2012.08.013)

Borer, J.S., Bohm, M., Ford, I. , Komajda, M., Tavazzi, L., Sendon, J.L., Alings, M., Lopez-de-Sa, E. and Swedberg, K. (2012) Effect of ivabradine on recurrent hospitalization for worsening heart failure in patients with chronic systolic heart failure: the SHIFT Study. European Heart Journal, 33(22), pp. 2813-2820. (doi: 10.1093/eurheartj/ehs259)

Steg, P.G., Greenlaw, N. , Tardif, J.-C., Tendera, M., Ford, I. , Kaab, S., Abergel, H., Fox, K.M. and Ferrari, R. (2012) Women and men with stable coronary artery disease have similar clinical outcomes: insights from the international prospective CLARIFY registry. European Heart Journal, 33(22), pp. 2831-2840. (doi: 10.1093/eurheartj/ehs289)

Miller, A. M. et al. (2012) Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes? PLoS ONE, 7(10), e47830. (doi: 10.1371/journal.pone.0047830) (PMID:23112853) (PMCID:PMC3480428)

Kaptoge, S. et al. (2012) C-reactive protein, fibrinogen, and cardiovascular disease prediction. New England Journal of Medicine, 367(14), pp. 1310-1320. (doi: 10.1056/NEJMoa1107477)

Mihaylova, B. et al. (2012) The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet, 380(9841), pp. 581-590. (doi: 10.1016/S0140-6736(12)60367-5)

Payne, A. R. et al. (2012) Microvascular resistance predicts myocardial salvage and infarct characteristics in ST-elevation myocardial infarction. Journal of the American Heart Association, 1(4), e002246. (doi: 10.1161/JAHA.112.002246)

Hocking, L.J. et al. (2012) Heritability of chronic pain in 2195 extended families. European Journal of Pain, 16(7), pp. 1053-1063. (doi: 10.1002/j.1532-2149.2011.00095.x)

Knox, S. et al. (2012) 25-hydroxyvitamin D is lower in deprived groups, but is not associated with carotid intima media thickness or plaques: results from pSoBid. Atherosclerosis, 223(2), pp. 437-441. (doi: 10.1016/j.atherosclerosis.2012.05.001) (PMID:22632919)

Preiss, D. et al. (2012) Lipid-modifying therapies and risk of pancreatitis: a meta-analysis. JAMA: Journal of the American Medical Association, 308(8), pp. 804-811. (doi: 10.1001/jama.2012.8439)

Di Angelantonio, E. et al. (2012) Lipid-related markers and cardiovascular disease prediction. JAMA: Journal of the American Medical Association, 307(23), pp. 2499-2506. (doi: 10.1001/jama.2012.6571)

Deshmukh, H.A. et al. (2012) Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a). Journal of Lipid Research, 53(5), pp. 1000-1011. (doi: 10.1194/jlr.P021113)

Deshmukh, H.A. et al. (2012) Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importnace of Lp(a). Journal of Lipid Research, 53, pp. 1000-1011. (doi: 10.1194/jlr.P021113)

Estrada, K. et al. (2012) Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics, 44(5), pp. 491-501. (doi: 10.1038/ng.2249)

Swedberg, K., Komajda, M., Bohm, M., Borer, J., Robertson, M., Tavazzi, L. and Ford, I. (2012) Effects on outcomes of heart rate reduction by Ivabradine in patients with congestive heart failure: Is there an influence of beta-blocker dose? Findings from the SHIFT (Systolic Heart Failure Treatment with I-f inhibitor ivabradine Trial) Study. Journal of the American College of Cardiology, 59(22), pp. 1938-1945. (doi: 10.1016/j.jacc.2012.01.020)

Swerdlow, D.I. et al. (2012) The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet, 379(9822), pp. 1214-1224. (doi: 10.1016/S0140-6736(12)60110-X)

Nanchen, D. et al. (2012) Subclinical thyroid dysfunction and the risk of heart failure in older persons at high cardiovascular risk. Journal of Clinical Endocrinology and Metabolism, 97(3), pp. 852-861. (doi: 10.1210/jc.2011-1978)

McGuinness, D. et al. (2012) Socio-economic status is associated with epigenetic differences in the pSoBid cohort. International Journal of Epidemiology, 41(1), pp. 151-160. (doi: 10.1093/ije/dyr215)

Rapsomaniki, E., White, I.R., Wood, A.M., Thompson, S.G. and Ford, I. (2012) A framework for quantifying net benefits of alternative prognostic models. Statistics in Medicine, 31(2), pp. 114-130. (doi: 10.1002/sim.4362)

Akao, H. et al. (2012) Genetic variation at the SLCO1B1 gene locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly. Atherosclerosis, 220(2), pp. 413-417. (doi: 10.1016/j.atherosclerosis.2011.09.028)

Akao, H. et al. (2012) KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. Atherosclerosis, 220(2), pp. 456-462. (doi: 10.1016/j.atherosclerosis.2011.11.037)

Charchar, F.J. et al. (2012) Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome. Lancet, 379(9819), pp. 915-922. (doi: 10.1016/S0140-6736(11)61453-0)

Chasman, D.I. et al. (2012) Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Human Molecular Genetics, 21(24), pp. 5329-5343. (doi: 10.1093/hmg/dds369)

Emberson, J.R. et al. (2012) Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy. PLoS ONE, 7(1), e29849. (doi: 10.1371/journal.pone.0029849) (PMID:22276132) (PMCID:PMC3261846)

Gibson, G. et al. (2012) Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genetics, 8(3), e1002584. (doi: 10.1371/journal.pgen.1002584)

Jackson, C.E. et al. (2012) Microvolt T-wave alternans (MTWA) testing in 'real world' heart failure (HF): a study of prevalence and incremental prognostic value. Heart, 2012(98), A12. (doi: 10.1136/heartjnl-2012-301877b.17)

Jackson, C.E. et al. (2012) Microvolt T-wave alternans testing should be used to guide arrhythmic therapy in heart failure patients: reply. European Journal of Heart Failure, 14(6), p. 678. (doi: 10.1093/eurjhf/hfs077)

Jackson, C.E. et al. (2012) Profile of microvolt T-wave alternans testing in 1003 patients hospitalized with heart failure. European Journal of Heart Failure, 14(4), pp. 377-386. (doi: 10.1093/eurjhf/hfs010)

Manning, A.K. et al. (2012) A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature Genetics, 44, pp. 659-669. (doi: 10.1038/ng.2274)

Poortvliet, R.K.E. et al. (2012) Blood pressure variability and cardiovascular risk in the PROspective study of pravastatin in the elderly at risk (PROSPER). PLoS ONE, 7(12), e52438. (doi: 10.1371/journal.pone.0052438) (PMID:23285043) (PMCID:PMC3527505)

Shiffman, D. et al. (2012) Genome-wide study of gene variants associated with differential cardiovascular event reduction by Pravastatin therapy. PLoS ONE, 7(5), e38240. (doi: 10.1371/journal.pone.0038240) (PMID:22666496) (PMCID:PMC3364212)

Steg, P.G., Ferrari, R., Ford, I. , Greenlaw, N. , Tardif, J.-C., Tendera, M., Abergel, H. and Fox, K. (2012) Heart rate and use of beta-blockers in stable outpatients with coronary artery disease. PLoS ONE, 7(5), e36284. (doi: 10.1371/journal.pone.0036284) (PMID:22570699) (PMCID:PMC3343045)

Stock, S.J., Ferguson, E., Duffy, A., Ford, I. , Chalmers, J. and Norman, J.E. (2012) Outcomes of elective induction of labour compared with expectant management: population based study. British Medical Journal, 344, e2838. (doi: 10.1136/bmj.e2838)

Trompet, S., Jukema, W., Mooijaart, S.P., Ford, I. , Stott, D.J. , Westendorp, R.G.J. and de Craen, A.J.M. (2012) Genetic variation in galectin-3 gene associates with cognitive function at old age. Neurobiology of Aging, 33(9), 2232.e1-2232.e9. (doi: 10.1016/j.neurobiolaging.2012.05.001)

Wormser, D. et al. (2012) Adult height and the risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis. International Journal of Epidemiology, 41(5), pp. 1419-1433. (doi: 10.1093/ije/dys086)

2011

Ford, I. et al. (2011) The inverse relationship between alanine aminotransferase in the normal range and adverse cardiovascular and non-cardiovascular outcomes. International Journal of Epidemiology, 40(6), pp. 1530-1538. (doi: 10.1093/ije/dyr172)

Berry, C. , Lloyd, S.M. , Wang, Y., MacDonald, A. and Ford, I. (2011) The changing course of aortic valve disease in Scotland: hospitalizations, outcomes and temporal trends. Circulation, 124(21S), A16931.

van Es, A.C.G.M. et al. (2011) Cerebral microbleeds and cognitive functioning in the PROSPER study. Neurology, 77(15), pp. 1446-1452. (doi: 10.1212/WNL.0b013e318232ab1d)

Trompet, S. et al. (2011) Replication of LDL SWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses. BMC Medical Genetics, 12, p. 131. (doi: 10.1186/1471-2350-12-131)

Welsh, P. et al. (2011) Circulating interleukin-10 and risk of cardiovascular events: a prospective study in the elderly at risk. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(10), pp. 2338-2344. (doi: 10.1161/ATVBAHA.111.231795) (PMID:21757655)

Ekman, I., Chassany, O., Komajda, M., Bohm, M., Borer, J.S., Ford, I. , Tavazzi, L. and Swedberg, K. (2011) Heart rate reduction with ivabradine and health related quality of life in patients with chronic heart failure: results from the SHIFT study. European Heart Journal, 32(19), pp. 2395-2404. (doi: 10.1093/eurheartj/ehr343)

Mooijaart, S.P. et al. (2011) C-Reactive protein and genetic variants and cognitive decline in old age: the PROSPER Study. PLoS ONE, 6(9), e23890. (doi: 10.1371/journal.pone.0023890) (PMID:21915265) (PMCID:PMC3168438)

Trew, G. et al. (2011) Gynaecological endoscopic evaluation of 4% icodextrin solution: a European, multicentre, double-blind, randomized study of the efficacy and safety in the reduction of de novo adhesions after laparoscopic gynaecological surgery. Human Reproduction, 26(8), pp. 2015-2027. (doi: 10.1093/humrep/der135)

Bousser, M.G. et al. (2011) Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trial. Lancet, 377(9782), pp. 2013-2022. (doi: 10.1016/S0140-6736(11)60600-4)

Widya, R. L. et al. (2011) Increased amygdalar and hippocampal volumes in elderly obese individuals with or at risk of cardiovascular disease. American Journal of Clinical Nutrition, 93(6), pp. 1190-1195. (doi: 10.3945/ajcn.110.006304)

Logue, J. , Murray, H.M., Welsh, P. , Shepherd, J., Packard, C. , Macfarlane, P., Cobbe, S., Ford, I. and Sattar, N. (2011) Obesity is associated with fatal coronary heart disease independently of traditional risk factors and deprivation. Heart, 97(7), pp. 564-568. (doi: 10.1136/hrt.2010.211201)

Rahimi, K. et al. (2011) Effect of statins on atrial fibrillation: collaborative meta-analysis of published and unpublished evidence from randomised controlled trials. British Medical Journal, 342, d1250. (doi: 10.1136/bmj.d1250)

Tendera, M., Talajic, M., Robertson, M., Tardif, J.-C., Ferrari, R., Ford, I. , Steg, P.G. and Fox, K. (2011) Safety of Ivabradine in patients with coronary artery disease and left ventricular systolic dysfunction (from the BEAUTIFUL Holter Substudy). American Journal of Cardiology, 107(6), pp. 805-811. (doi: 10.1016/j.amjcard.2010.10.065)

Wensley, F. et al. (2011) Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. British Medical Journal, 342, d548-d548. (doi: 10.1136/bmj.d548)

Ceconi, C. et al. (2011) Effect of heart rate reduction by ivabradine on left ventricular remodelling in the echocardiographic substudy of BEAUTIFUL. International Journal of Cardiology, 146(3), pp. 408-414. (doi: 10.1016/j.ijcard.2010.10.125)

Wade, A.G., Crawford, G., Ford, I. , McConnachie, A. , Nir, T., Laudon, M. and Zisapel, N. (2011) Prolonged release melatonin in the treatment of primary insomnia: evaluation of the age cut-off for short- and long-term response. Current Medical Research and Opinion, 27(1), pp. 87-98. (doi: 10.1185/03007995.2010.537317)

Freeman, D. J. et al. (2011) Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). BMC Geriatrics, 11, 8. (doi: 10.1186/1471-2318-11-8) (PMID:21342490) (PMCID:PMC3053238)

Li, Y. et al. (2011) Genetic variants in the KIF6 region and coronary event reduction from statin therapy. Human Genetics, 129(1), pp. 17-23. (doi: 10.1007/s00439-010-0892-6)

Macfarlane, P.W., Murray, H., Sattar, N. , Stott, D.J. , Ford, I. , Buckley, B., Jukema, J.W., Westendorp, R.G.J. and Shepherd, J. (2011) The incidence and risk factors for new onset atrial fibrillation in the PROSPER study. Europace, 13(5), pp. 634-639. (doi: 10.1093/europace/eur016)

Mutsaerts, H.J.M.M. et al. (2011) Diastolic carotid artery wall shear stress is associated with cerebral infarcts and periventricular white matter lesions. Stroke, 42(12), pp. 3497-3501. (doi: 10.1161/STROKEAHA.111.614453)

Packard, C.J. et al. (2011) Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study. BMC Public Health, 11, p. 42. (doi: 10.1186/1471-2458-11-42)

Payne, A.R., Berry, C. , Doolin, O., McEntegart, M.B., Robb, S.D., Petrie, M.C., Ford, I. and Oldroyd, K. (2011) Myocardial salvage during primary PCI can be predicted in the cath lab. Heart, 97(Sup. 1), A73-A74. (doi: 10.1136/heartjnl-2011-300198.129)

Pons, D. et al. (2011) Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies. Heart, 97(2), pp. 143-150. (doi: 10.1136/hrt.2010.199927)

Reil, J.C., Custodis, F., Swedberg, K., Komajda, M., Borer, J.S., Ford, I. , Tavazzi, L., Laufs, U. and Bohm, M. (2011) Heart rate reduction in cardiovascular disease and therapy. Clinical Research in Cardiology, 100(1), pp. 11-19. (doi: 10.1007/s00392-010-0207-x)

Shiels, P.G. et al. (2011) Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort. PLoS ONE, 6(7), e22521. (doi: 10.1371/journal.pone.0022521) (PMID:21818333) (PMCID:PMC3144896)

Smith, N. L. et al. (2011) Genetic predictors of fibrin D-Dimer levels in healthy adults. Circulation, 123(17), pp. 1864-1872. (doi: 10.1161/CIRCULATIONAHA.110.009480)

Tardif, J.-C., O'Meara, E., Komajda, M., Bohm, M., Borer, J. S., Ford, I. , Tavazzi, L. and Swedberg, K. (2011) Effects of selective heart rate reduction with ivabradine on left ventricular remodelling and function: results from the SHIFT echocardiography substudy. European Heart Journal, 32(20), pp. 2507-2515. (doi: 10.1093/eurheartj/ehr311)

Van Veldhuisen, D.J. et al. (2011) Intrathroacic impedance monitoring, audible patient alerts and outcome in patients with heart failure. Circulation, 124(16), pp. 1719-1726.

van Veldhuisen, D.J. et al. (2011) Intrathoracic impedance monitoring, audible patient alerts, and outcome in patients with heart failure. Circulation, 124(16), pp. 1719-1726. (doi: 10.1161/CIRCULATIONAHA.111.043042)

2010

Bohm, M., Swedberg, K., Komajda, M., Borer, J.S., Ford, I. , Dubost-Brama, A., Lerebours, G. and Tavazzi, L. (2010) Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial. Lancet, 376(9744), pp. 886-894. (doi: 10.1016/S0140-6736(10)61259-7)

Swedkerg, K., Komajda, M., Bohm, M., Borer, J.S., Ford, I. , Dubost-Brama, A., Lerebours, G. and Tavazzi, L. (2010) Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet, 376(9744), pp. 875-885. (doi: 10.1016/S0140-6736(10)61198-1)

Iakoubova, O.A. et al. (2010) KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study. European Journal of Cardiovascular Prevention and Rehabilitation, 17(4), pp. 455-461. (doi: 10.1097/HJR.0b013e328336a0dd)

Ford, I. , Robertson, M., Shepherd, J. and Cobbe, S. (2010) Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet, 375(9726), pp. 1634-1639. (doi: 10.1016/S0140-6736(10)60545-4)

Caslake, M.J. et al. (2010) Lipoprotein-associated phospholipase A₂ inflammatory biomarkers, and risk of cardiovascular disease in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). Atherosclerosis, 210(1), pp. 28-34. (doi: 10.1016/j.atherosclerosis.2009.10.041)

Polisecki, E. et al. (2010) Genetic variation at the NPC1L1 gene locus, plasma lipoproteins, and heart disease risk in the elderly. Journal of Lipid Research, 51(5), pp. 1201-1207. (doi: 10.1194/jlr.P001172)

Sattar, N. et al. (2010) Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet, 375(9716), pp. 735-742. (doi: 10.1016/S0140-6736(09)61965-6)

Parthasarathy, H. K., Alhashmi, K., McMahon, A. D. , Struthers, A. D., McInnes, G. T., Ford, I. , Connell, J. M. and MacDonald, T. M. (2010) Does the ratio of serum aldosterone to plasma renin activity predict the efficacy of diuretics in hypertension? Results of RENALDO. Journal of Hypertension, 28(1), pp. 170-177. (doi: 10.1097/HJH.0b013e328332b79b)

Matthan, N.R., Resteghini, N., Robertson, M., Ford, I. , Shepherd, J., Packard, C. , Buckley, B.M., Jukema, J.W., Lichenstein, A.H. and Schaefer, E.J. (2010) Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial. Journal of Lipid Research, 51, pp. 202-209. (doi: 10.1194/jlr.M900032-JLR200)

Swedberg, K., Komajda, M., Böhm, M., Borer, J.S., Ford, I. and Tavazzi, L. (2010) Rationale and design of a randomized, double-blind, placebo-controlled outcome trial of ivabradine in chronic heart failure: the Systolic Heart Failure Treatment with the If Inhibitor Ivabradine Trial (SHIFT). European Journal of Heart Failure, 12(1), pp. 75-81. (doi: 10.1093/eurjhf/hfp154)

Trompet, S. et al. (2010) Pravastatin and cognitive function in the elderly. Results of the PROSPER study. Journal of Neurology, 257(1), pp. 85-90. (doi: 10.1007/s00415-009-5271-7)

Welsh, P. et al. (2010) Unraveling the directional link between adiposity and inflammation: a bidirectional mendelian randomization approach. Journal of Clinical Endocrinology and Metabolism, 95(1), pp. 93-99. (doi: 10.1210/jc.2009-1064)

Elliot, H.L., Lloyd, S.M. , Ford, I. and Meredith, P.A. (2010) Improving blood pressure control in patients with diabetes mellitus and high cardiovascular risk. International Journal of Hypertension, 2010(Articl), (doi: 10.4061/2010/490769)

Hennerici, M.G., Bots, M.L., Ford, I. , Laurent, S. and Touboul, P.J. (2010) Rationale, design and population baseline characteristics of the PERFORM Vascular Project: an ancillary study of the Prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history oF ischemic stroke or transient ischemic attack (PERFORM) trial. Cardiovascular Drugs and Therapy, 24(2), pp. 175-180. (doi: 10.1007/s10557-010-6231-2)

Preiss, D. , Welsh, P. , Murray, H., Shepherd, J., Packard, C. , Macfarlane, P., Cobbe, S., Ford, I. and Sattar, N. (2010) Fasting plasma glucose in non-diabetic participants and the risk for incident cardiovascular events, diabetes, and mortality: results from WOSCOPS 15-year follow-up(dagger). European Heart Journal, 31(10), pp. 1230-1236. (doi: 10.1093/eurheartj/ehq095)

Ray, K. K., Seshasai, S. R. K., Erqou, S., Sever, P., Jukema, J. W., Ford, I. and Sattar, N. (2010) Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants. Archives of Internal Medicine, 170(12), pp. 1024-1031. (doi: 10.1001/archinternmed.2010.182)

Sofat, R. et al. (2010) Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. Circulation, 121(1), pp. 52-62. (doi: 10.1161/CIRCULATIONAHA.109.865444)

Stott, D.J. et al. (2010) Activation of Hemostasis and Decline in Cognitive Function in Older People. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(3), pp. 605-611. (doi: 10.1161/ATVBAHA.109.199448)

Wade, A.G., Ford, I. , Crawford, G., McConnachie, A. , Nir, T., Laudon, M. and Zisapel, N. (2010) Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety. BMC Medicine, 8, p. 51. (doi: 10.1186/1741-7015-8-51)

2009

Trompet, S. et al. (2009) Apolipoprotein E genotype, plasma cholesterol, and cancer: a mendelian randomization study. American Journal of Epidemiology, 170(11), pp. 1415-1421. (doi: 10.1093/aje/kwp294)

Batty, G.D., Wang, Y., Brouilette, S.W., Shiels, P.G., Packard, C.J., Moore, J., Samani, N.J. and Ford, I. (2009) Socioeconomic status and telomere length: the West of Scotland Coronary Prevention Study. Journal of Epidemiology and Community Health, 63(10), pp. 839-841. (doi: 10.1136/jech.2009.088427)

Fox, K., Ford, I. , Steg, G., Tendera, M., Robertson, M. and Ferrari, R. (2009) Relationship between Ivabradine treatment and cardiovascular outcomes in patients with stable coronary artery disease and left ventricular systolic dysfunction with limiting angina: a subgroup analysis of the randomized, controlled BEAUTIFUL trial. European Heart Journal, 30(19), pp. 2337-2345. (doi: 10.1093/eurheartj/ehp358)

Bousser, M.G., Amarenco, P., Chamorro, A., Fisher, M., Ford, I. , Fox, K., Hennerici, M., Mattle, H.P. and Rothwell, P.M. (2009) The prevention of cerebrovascular and cardiovascular events of ischemic origin with Terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) study: Baseline characteristics of the population. Cerebrovascular Diseases, 27(6), p. 608. (doi: 10.1159/000216835)

Davidson, K.M. et al. (2009) Cognitive behaviour therapy for violent men with antisocial personality disorder in the community: an exploratory randomized controlled trial. Psychological Medicine, 39(4), pp. 569-577. (doi: 10.1017/S0033291708004066)

Bousser, M.G., Amarenco, P., Chamorro, A., Fisher, M., Ford, I. , Fox, K., Hennerici, M.G., Mattle, H.P. and Rothwell, P.M. (2009) Rationale and design of a randomized, double-blind, parallel-group study of Terutroban 30 mg/day versus Aspirin 100 mg/day in stroke patients: the prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) study. Cerebrovascular Diseases, 27(5), p. 509. (doi: 10.1159/000212671)

Shepherd, J., Lowe, G., Ford, I. and Robertson, M. (2009) Correcting for multivariate measurement error by regression calibration in meta-analyses of epidemiological studies. Statistics in Medicine, 28(7), pp. 1067-1092. (doi: 10.1002/sim.3530)

Stott, D.J., Welsh, P.I., Rumley, A., Robertson, M., Ford, I. , Sattar, N.A., Westendorp, R.G.J., Jukema, J.W., Cobbe, S. and Lowe, G.D. (2009) Adipocytokines and risk of stroke in older people: a nested case-control study. International Journal of Epidemiology, 38(1), pp. 253-261. (doi: 10.1093/ije/dyn215)

Welsh, P. et al. (2009) Leptin Predicts Diabetes but Not Cardiovascular Disease Results from a large prospective study in an elderly population. Diabetes Care, 32(2), pp. 308-310. (doi: 10.2337/dc08-1458)

Deans, K.A. et al. (2009) Differences in atherosclerosis according to area level socioeconomic deprivation: cross sectional, population based study. British Medical Journal, 339, b4170. (doi: 10.1136/bmj.b4170)

Ford, I. et al. (2009) Reduced glomerular filtration rate and its association with clinical outcome in older patients at risk of vascular events: secondary analysis. PLoS Medicine, 6(1), e1000016. (doi: 10.1371/journal.pmed.1000016)

Jackson, C.E., Dalzell, J.R., Bezlyak, V., Tsorlalis, I.K., Myles, R.C., Spooner, R., Ford, I., Petrie, M.C., Cobbe, S. and McMurray, J.J. (2009) Red cell distribution width has incremental prognostic value to B-type natriuretic peptide in acute heart failure. European Journal of Heart Failure, 11(12), pp. 1152-1154. (doi: 10.1093/eurjhf/hfp157)

Sattar, N.A. et al. (2009) Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events? PLoS Medicine, 6(6), e1000099. (doi: 10.1371/journal.pmed.1000099)

Sattar, N. et al. (2009) Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly. Diabetologia, 52(2), pp. 235-239.

Trompet, S., de Craen, A.J.M., Mooijaart, S., Stott, D.J. , Ford, I. , Sattar, N.A. , Jukema, W. and Westendorp, R.G.J. (2009) High innate production capacity of proinflammatory cytokines increases risk for death from cancer: results of the PROSPER study. Clinical Cancer Research, 15(24), pp. 7744-7748. (doi: 10.1158/1078-0432.CCR-09-2152)

Watkins, S. et al. (2009) Validation of magnetic resonance myocardial perfusion imaging with fractional flow reserve for the detection of significant coronary heart disease. Circulation, 120(22), pp. 2207-2213. (doi: 10.1161/CIRCULATIONAHA.109.872358)

Weir, R.A.P., Mark, P.B. , Petrie, C.J., Clements, S., Steedman, T., Ford, I. , Ng, L.L., Squire, I.B., Wagner, G.S. and McMurray, J.J.V. (2009) Left ventricular remodeling after acute myocardial infarction: Does eplerenone have an effect? American Heart Journal, 157(6), pp. 1088-1096. (doi: 10.1016/j.ahj.2009.04.001)

2008

Fox, K., Ford, I. , Steg, P.G., Tendera, M. and Ferrari, R. (2008) Ivabradine in heart failure: what about digoxin? Lancet, 372(9656), pp. 2113-2114. (doi: 10.1016/S0140-6736(08)61924-8)

Fox, K., Ford, I. , Steg, P.G., Tendera, M. and Ferrari, R. (2008) Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial. Lancet, 372(9641), pp. 807-816. (doi: 10.1016/S0140-6736(08)61170-8)

Fox, K., Ford, I. , Steg, P.G., Tendera, M., Robertson, M. and Ferrari, R. (2008) Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial. Lancet, 372(9641), pp. 817-821. (doi: 10.1016/S0140-6736(08)61171-X)

Braunschweig, F. et al. (2008) Can monitoring of intrathoracic impedance reduce morbidity and mortality in patients with chronic heart failure? Rationale and design of the Diagnostic Outcome Trial in Heart Failure (DOT-HF). European Journal of Heart Failure, 10(9), pp. 907-916. (doi: 10.1016/j.ejheart.2008.06.016)

Polisecki, E. et al. (2008) Genetic variation at the LDL receptor and HMG-CoA reductase gene loci, lipid levels, statin response and cardiovascular disease incidence in PROSPER. Atherosclerosis, 200(1), pp. 109-114.

Ferrari, R., Ford, I. , Fox, K., Steg, P.G. and Tendera, M. (2008) The BEAUTIFUL study: randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction – baseline characteristics of the study population. Cardiology, 110(4), pp. 271-282. (doi: 10.1159/000112412)

Sattar, N. et al. (2008) Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies. Lancet, 371(9628), pp. 1927-1935. (doi: 10.1016/S0140-6736(08)60602-9)

Ford, I. , Murray, H. and Cobbe, S. (2008) Long-term follow-up of the West of Scotland Coronary Prevention Study - Reply. New England Journal of Medicine, 358(2), pp. 194-195.

Downs, J.R. et al. (2008) Efficacy of cholesterol-lowering therapy in 18 686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet, 371(9607), pp. 117-125. (doi: 10.1016/S0140-6736(08)60104-X)

Parthasarathy, H., Alhashmi, K., Struthers, A., Connell, J., McInnes, G., Ford, I. and MacDonald, T. (2008) Does the aldosterone: Renin ratio predict the efficacy of spironolactone over bendroflumethiazide in hypertension: The Renaldo study. Heart, 94, A19-A19.

Poliseckia, E. et al. (2008) Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population. Atherosclerosis, 200(1), pp. 95-101. (doi: 10.1016/j.atherosclerosis.2007.12.005)

Stott, D., Falconer, A., Kerr, G., Murray, H., Trompet, S., Westendorp, R., Buckley, B., De Craen, A., Sattar, N. and Ford, I. (2008) Does Low to Moderate Alcohol Intake Protect Against Cognitive Decline in Older People? Journal of the American Geriatrics Society, 56(12), pp. 2217-2224. (doi: 10.1111/j.1532-5415.2008.02007.x)

Trompet, S. et al. (2008) Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke. The PROSPER study. Experimental Gerontology, 43(8), pp. 801-805. (doi: 10.1016/j.exger.2008.04.006)

Trompet, S. et al. (2008) Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study. Brain, 131(4), pp. 1069-1077. (doi: 10.1093/brain/awn023)

Velupillai, Y.N. et al. (2008) Psychological, social and biological determinants of ill health (pSoBid): study protocol of a population-based study. BMC Public Health, 8(126), (doi: 10.1186/1471-2458-8-126)

Wild, S., Macleod, F., McKnight, J., Watt, G., Mackenzie, C., Ford, I. , McConnachie, A. and Lindsay, R. (2008) Impact of deprivation on cardiovascular risk factors in people with diabetes: an observational study. Diabetic Medicine, 25(2), pp. 194-199. (doi: 10.1111/j.1464-5491.2008.02382.x)

2007

Packard, C.J. et al. (2007) Association between apolipoprotein E4 and cognitive decline in elderly adults. Journal of the American Geriatrics Society, 55(11), pp. 1777-1785. (doi: 10.1111/j.1532-5415.2007.01415.x)

Sattar, N. , McConnachie, A. , Ford, I. , Gaw, A., Cleland, S.J., Forouhi, N.G., Macfarlane, P., Shepherd, J., Cobbe, S. and Packard, C. (2007) Serial metabolic measurements and conversion to type 2 diabetes in the West of Scotland Coronary Prevention Study - Specific elevations in alanine aminotransferase and triglycerides suggest hepatic fat accumulation as a potential contributing factor. Diabetes, 56(4), pp. 984-991. (doi: 10.2337/db06-1256)

Brouilette, S., Moore, J., McMahon, D., Thompson, J., Ford, I. , Shepherd, J., Packard, C. and Samani, N. (2007) Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet, 369, pp. 107-114.

Brown, D., Kauermann, G. and Ford, I. (2007) A partial likelihood approach to smooth estimation of dynamic covariate effects using penalised splines. Biometrical Journal, 49, pp. 441-452. (doi: 10.1002/bimj.200510325)

Capell, H. et al. (2007) Combination therapy with sulfasalazine and methotrexate is more effective than either drug alone in patients with rheumatoid arthritis with a suboptimal response to sulfasalazine: results from the double-blind placebo-controlled MASCOT study. Annals of the Rheumatic Diseases, 66, pp. 235-241. (doi: 10.1136/ard.2006.057133) (PMID:16926184)

Ford, I., Murray, H., Shepherd, J., Packard, C. , Macfarlane, P. and Cobbe, S. (2007) Long-term follow-up of the West of Scotland Coronary Prevention Study. New England Journal of Medicine, 357(15), pp. 1477-1486. (doi: 10.1056/NEJMoa065994)

Parthasarathy, H.K., Alhashmi, K., McMahon, A., Struthers, A.D., Connell, J.M.C., McInnes, G.T., Ford, I. and MacDonald, T.M. (2007) Does the aldosterone : renin ratio predict the efficacy of spironolactone over bendroflumethiazide in hypertension? A clinical trial protocol for RENALDO (RENin-ALDOsterone) study. BMC Cardiovascular Disorders, 7(14), (doi: 10.1186/1471-2261-7-14)

Ruzyllo, W., Tendera, M., Ford, I. and Fox, K. (2007) Antianginal efficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris - A 3-month randomised, double-blind, multicentre, noninferiority trial. Drugs, 67, pp. 393-405.

Sattar, N. et al. (2007) C-reactive protein and prediction of coronary heart disease and global vascular events in the prospective study of pravastatin in the elderly at risk (PROSPER). Circulation, 115(8), pp. 981-989. (doi: 10.1161/CIRCULATIONAHA.106.643114)

Trompet, S. et al. (2007) Genetic variation in the interleukin-10 gene promoter and risk of coronary and cerebrovascular events - The PROSPER study. In: Rattan, S. and Akman, S. (eds.) Biogerontology: Mechanisms and Interventions. Series: Annals of the New York Academy of Sciences (1100). Blackwell Publishing: Oxford, pp. 189-198. ISBN 978-1-57331-679-8 (doi: 10.1196/annals.1395.018)

Wade, A., Ford, I. , Crawford, G., McMahon, A. , Nir, T., Laudon, M. and Zisapel, N. (2007) Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of age sleep and next-day alertness outcomes. Current Medical Research and Opinion, 23, pp. 2597-2605. (doi: 10.1185/030079907X233098)

2006

Osman, I., Mackenzie, F., Norrie, J., Murray, H., Greer, I.A., Norman, J.E. and Ford, I. (2006) The 'PRIM' study: a randomized comparison of prostaglandin E2 gel with the nitric donor isosorbide mononitrate for cervical ripening before the induction of labour at term. American Journal of Obstetrics and Gynecology, 194(4), pp. 1012-1021. (doi: 10.1016/j.ajog.2005.10.812)

Al Benna, S., Hamilton, C.A., McClure, J.D. , Rogers, P.N., Berg, G.A., Ford, I. , Delles, C. and Dominiczak, A.F. (2006) Low-density lipoprotein cholesterol determines oxidative stress and endothelial dysfunction in saphenous veins from patients with coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(1), pp. 218-223. (doi: 10.1161/01.ATV.0000193626.22269.45)

Fox, K., Ferrari, R., Tendera, M., Steg, P., Ford, I. and BEAUTIFUL Steering Committee, (2006) Rationale and design of a randomized, double-blind, placebo-controlled trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction: the morBidity-mortality EvAlUaTion of the I-f inhibitor ivabradine in pat. American Heart Journal, 152, pp. 860-866. (doi: 10.1016/j.ahj.2006.01.013)

Smith, B.H. et al. (2006) Generation Scotland: the Scottish family health study; a new resource for researching genes and heritability. BMC Medical Genetics, 7, p. 74. (doi: 10.1186/1471-2350-7-74)

Walker, A., McMurray, J. , Stewart, S., Berger, W., McMahon, A., Dargie, H., Fox, K., Hillis, S., Henderson, N. and Ford, I. (2006) Economic evaluation of the impact of nicorandil in angina (IONA) trial. Heart, 92, pp. 619-624. (doi: 10.1136/hrt.2003.026385) (PMID:16614274) (PMCID:PMC1860935)

Will, M., Bernacca, G., Bell, E., Tolland, M., Lowe, G., Rumley, A., Murray, H., Ford, I. and Wheatley, D. (2006) Our inability to predict thromboembolic events after prosthetic valve surgery. Journal of Heart Valve Disease, 15(4), pp. 570-580.

2005

Tardif, J.-C., Ford, I. , Tendera, M., Bourassa, M.G. and Fox, K. (2005) Efficacy of ivabradine, a new selective I_f inhibitor, compared with atenolol in patients with chronic stable angina. European Heart Journal, 26(23), pp. 2529-2536. (doi: 10.1093/eurheartj/ehi586)

Brady, A.J.B., Norrie, J. and Ford, I. (2005) Statin prescribing: is the reality meeting the expectations of primary care? British Journal of Cardiology, 12(5), pp. 397-400.

ten Dam, V.H., van den Heuvel, D.M.J., van Buchem, M.A., Westendorp, R.G.J., Bollen, E.L.E.M., Ford, I. , de Craen, A.J.M. and Blauw, G.J. (2005) Effect of pravastatin on cerebral infarcts and white matter lesions. Neurology, 64(10), pp. 1807-1809. (doi: 10.1212/01.WNL.0000161844.00797.73)

Brzezinski, A., Vangel, M., Wurtman, R., Norrie, G., Zhdanova, I., Ben-Shushan, A. and Ford, I. (2005) Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Medicine Reviews, 9, pp. 41-50. (doi: 10.1016/j.smrv.2004.06.004)

Dargie, H. et al. (2005) Determinants of coronary events in patients with stable angina: Results from the Impact of Nicorandil in Angina Study. American Heart Journal, 150, (doi: 10.1016/j.ahj.2005.03.040)

Kamper, A., Stott, D. , Hyland, M., Murray, H. and Ford, I. (2005) Predictors of functional decline in elderly people with vascular risk factors or disease. Age and Ageing, 34, pp. 450-455. (doi: 10.1093/ageing/afi137)

McMurray, J. , Kober, L., Robertson, M., Dargie, H., Colucci, W., Lopez-Sendon, J., Remme, W., Sharpe, D. and Ford, I. (2005) Antiarrhythmic effect of carvedilol after acute myocardial infarction - Results of the Carvedilol Post-Infarct Survival Control in Left Ventricular Dysfunction (CAPRICORN) trial. Journal of the American College of Cardiology, 45, pp. 525-530.

McMurray, J. , Kober, L., Robertson, M., Dargie, H., Colucci, W., Lopez-Sendon, J., Remme, W., Sharpe, N. and Ford, I. (2005) Antiarrythmic effect of carvedilol after acute myocardial infarction. Journal of the American College of Cardiology, 45(4), pp. 525-530. (doi: 10.1016/j.jacc.2004.09.076)

Packard, C.J. et al. (2005) Plasma lipoproteins and apolipoproteins as predictors of cardiovascular risk and treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Circulation, 112, pp. 3058-3065. (doi: 10.1161/CIRCULATIONAHA.105.526848)

Tardif, J., Ford, I., Tendera, M., Bourassa, M., Fox, K. and Initiative Investigators, (2005) Efficacy of ivabradine, a new selective I-f inhibitor, compared with atenolol in patients with chronic stable angina. European Heart Journal, 26, pp. 2529-2536. (doi: 10.1093/eurheartj/ehi586)

2004

Shepherd, J., Cobbe, S.M., Ford, I. , Isles, C.G., Lorimer, A.R., MacFarlane, P.W., McKillop, J.H. and Packard, C.J. (2004) Prevention of coronary heart disease with pravastatin in men with hypercholesterolaemia. Atherosclerosis Supplements, 5(3), pp. 91-97. (doi: 10.1016/j.atherosclerosissup.2004.08.029)

McCarey, D.W., McInnes, I.B. , Madhok, R., Hampson, R., Scherbakov, O., Ford, I. , Capell, H. and Sattar, N. (2004) Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial. Lancet, 363(9426), pp. 2015-2021. (doi: 10.1016/S0140-6736(04)16449-0) (PMID:15207950)

Cleland, J., Findlay, I., Jafri, S., Sutton, G., Falk, R., Bulpitt, C., Prentice, C., Ford, I. , Trainer, A. and Poole-Wilson, P. (2004) The Warfarin/Aspirin Study in Heart failure (WASH): A randomized trial comparing antithrombotic strategies for patients with heart failure. American Heart Journal, 148, pp. 157-164. (doi: 10.1016/j.ahj.2004.03.010)

Dargie, H. et al. (2004) Impact of nicorandil in angina: subgroup analyses. Heart, 90, pp. 1427-1430. (doi: 10.1136/hrt.2003.026310)

Ford, I. , Lowe, G.D.O., McMahon, A.D. , O'Reilly, D.S., Packard, C.J. and Rumley, A. (2004) Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 24, pp. 1529-1534. (doi: 10.1161/01.ATV.0000135995.39488.6c)

Kostis, J.B. et al. (2004) Collaborative meta-analysis of prospective studies of plasma fibrinogen and cardiovascular disease. European Journal of Cardiovascular Prevention and Rehabilitation, 11(1), pp. 9-17.

Lees, K.R. et al. (2004) Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial. Lancet, 363, pp. 439-445.

Sattar, N., Scherbakova, O., Ford, I., O'Reilly, D., Stanley, A., Forrest, E., MacFarlane, P., Packard, C. , Cobbe, S. and Shepherd, J. (2004) Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the West of Scotland Coronary Prevention Study. Diabetes, 53(11), pp. 2855-2860. (doi: 10.2337/diabetes.53.11.2855)

Sattar, N. et al. (2004) Metabolic syndrome and diabetes mellitus - Response. Circulation, 109(3), E23-E23.

2003

Sattar, N. et al. (2003) Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study. Circulation, 108(4), pp. 414-419. (doi: 10.1161/01.CIR.0000080897.52664.94) (PMID:12860911)

O'Dwyer, P.J. et al. (2003) Local or general anesthesia for open hernia repair: a randomized trial. Annals of Surgery, 237(4), pp. 574-579.

Daly, C., Norrie, J., Murdoch, D., Ford, I. , Dargie, H. and Fox, K. (2003) The value of routine non-invasive tests to predict clinical outcome in stable angina. European Heart Journal, 24, pp. 534-542. (doi: 10.1016/S0195-668X(02)00820-5)

Pell, J., Sirel, J., Marsden, A., Ford, I., Walker, N. and Cobbe, S. (2003) Presentation, management, and outcome of out of hospital cardiopulmonary arrest: comparison by underlying aetiology. Heart, 89(8), pp. 839-842. (doi: 10.1136/heart.89.8.839)

Pell, J. , Sirel, J., Walker, N., Cobbe, S., Marsden, A. and Ford, I. (2003) Public access defibrillators - Defibrillators in public places save lives - Reply. British Medical Journal, 326(7381), p. 163.

2002

Avorn, J. et al. (2002) Measuring the cost-effectiveness of lipid-lowering drugs in the elderly: the outcomes research and economic analysis components of the PROSPER trial. Controlled Clinical Trials, 23, pp. 757-773.

Dargie, H., Ford, I. , Fox, K. and Hillis, W. (2002) Effect of nicorandil on coronary events in patients with stable angina: the Impact Of Nicorandil in Angina (IONA) randomised trial. Lancet, 359, pp. 1269-1275.

Ford, I. et al. (2002) A prospective study of pravastatin in the elderly at risk (PROSPER): Screening experience and baseline characteristics. Current Controlled Trials in Cardiovascular Medicine, 3, p. 8. (doi: 10.1186/1468-6708-3-8)

Ford, I. and Norrie, J. (2002) The role of covariates in estimating treatment effects and risk in long-term clinical trials. Statistics in Medicine, 21, pp. 2899-2908. (doi: 10.1002/sim.1294)

Freeman, D.J. , Norrie, J., Caslake, M.J., Gaw, A., Ford, I. , Lowe, G.D.O., O'Reilly, D. S. J.,, Packard, C.J. and Sattar, N. (2002) C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes, 51(5), pp. 1596-1600. (doi: 10.2337/diabetes.51.5.1596)

Freeman, D.J. , Norrie, J., Caslake, M.J., Gaw, A., Ford, I. , Lowe, G.D.O., O'Reilly, D.S., Packard, C.J. and Sattar, N. (2002) C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes, 51(5), pp. 1596-1600.

Houx, P.J. et al. (2002) Testing cognitive function in elderly populations: the PROSPER study. Journal of Neurology, Neurosurgery and Psychiatry, 73(4), pp. 385-389. (doi: 10.1136/jnnp.73.4.385)

Kostis, J. et al. (2002) Design of the Omapatrilat in Persons with Enhanced Risk of Atherosclerotic events (OPERA) trial. American Journal of Hypertension, 15(2), pp. 193-198. (doi: S0895-7061(01)02048-9)

Otterstad, J. and Ford, I. (2002) The effect of carvedilol in patients with impaired left ventricular systolic function following an acute myocardial infarction - How do the treatment effects on total mortality and recurrent myocardial infarction in CAPRICORN compare with previous beta-bl. European Journal of Heart Failure, 4, pp. 501-506.

Shepherd, J. et al. (2002) Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet, 360(9346), pp. 1623-1630. (doi: 10.1016/S0140-6736(02)11600-X)

Simes, J., Furberg, C., Braunwald, E., Davis, B., Ford, I. , Tonkin, A. and Shepherd, J. (2002) Effects of pravastatin on mortality in patients with and without coronary heart disease across a broad range of cholesterol levels - The Prospective Pravastatin Pooling project. European Heart Journal, 23, pp. 207-215. (doi: 10.1053/euhj.2001.2775)

Streja, L., Packard, C. , Shepherd, J., Cobbe, S. and Ford, I. (2002) Factors affecting low-density lipoprotein and high-density lipoprotein cholesterol response to pravastatin in the West of Scotland Coronary Prevention Study (WOSCOPS). American Journal of Cardiology, 90(7), pp. 731-736. (doi: 10.1016/S0002-9149(02)02599-7)

2001

Blue, L. et al. (2001) Randomised controlled trial of specialist nurse intervention in heart failure. British Medical Journal, 323, pp. 715-718. (doi: 10.1136/bmj.323.7315.715)

Freeman, D. et al. (2001) Pravastatin and the development of diabetes mellitus - Evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study. Circulation, 103(3), pp. 357-362.

McDonagh, T., Cunningham, A., Morrison, C., McMurray, J. , Ford, I. , Morton, J. and Dargie, H. (2001) Left ventricular dysfunction, natriuretic peptides, and mortality in an urban population. Heart, 86, pp. 21-26.

Pell, J.P. , Sirel, J.M., Marsden, A.K., Ford, I. and Cobbe, S.M. (2001) Effect of reducing ambulance response times on deaths from out of hospital cardiac arrest: cohort study. British Medical Journal, 322, pp. 1385-1388. (doi: 10.1136/bmj.322.7299.1385)

2000

Packard, C.J. et al. (2000) Lipoprotein-associated phospholipse A2 as an independent predictor of coronary heart disease (WOSCOPS). New England Journal of Medicine, 343(16), pp. 1148-1155. (doi: 10.1056/NEJM200010193431603)

L'Itallien, G., Ford, I. , Norrie, J., LaPuerta, P., Ehreth, J., Jackson, J. and Shepherd, J. (2000) The cardiovascular event reduction tool(CERT)- a simplified cardiac risk prediction model developed from the West of Scotland coronary prevention study (WOSCOPS). American Journal of Cardiology, 85(6), pp. 720-724. (doi: 10.1016/S0002-9149(99)00847-4) (PMID:12000046)

Gaw, A., Brown, E.A., Docherty, G. and Ford, I. (2000) Is lipoprotein(a)-cholesterol a better predictor of vascular disease events than total lipoprotein(a) mass? a nested case control study from the West of Scotland coronary prevention study. Atherosclerosis, 148(1), pp. 95-100. (doi: 10.1016/S0021-9150(99)00259-2)

Lowe, G., Rumley, A., Norrie, J., Ford, I. , Shepherd, J., Cobbe, S., Macfarlane, P. and Packard, C. (2000) Blood rheology, cardiovascular risk factors, and cardiovascular disease: The West of Scotland Coronary Prevention Study. Thrombosis and Haemostasis, 84(4), pp. 553-558.

Packard, C.J. et al. (2000) Lipoprotein-associated phospholipase A(2) as an independent predictor of coronary heart disease. New England Journal of Medicine, 343(16), pp. 1148-1155.

Pell, J., Pell, A.C.H., Norrie, J., Ford, I. and Cobb, S.M. (2000) Effect of socioeconomic deprivation on waiting time for cardiac surgery: retrospective cohort study. British Medical Journal, 320, pp. 15-18. (doi: 10.1136/bmj.320.7226.15)

1999

Gaw, A., Brown, E.D., Docherty, G. and Ford, I. (1999) Use of the West of Scotland coronary prevention study bio-bank to provide new insights into the control of plasma lipoprotein(a) concentrations. Biochemical Society Transactions, 27(4), pp. 459-463.

Gaw, A., Docherty, G., Brown, E. and Ford, I. (1999) Predictors of plasma lipoprotein(a) concentration in the West of Scotland coronary prevention study cohort. Atherosclerosis, 143(2), pp. 445-450. (doi: 10.1016/S0021-9150(98)00305-0)

Cleland, J.G.F. et al. (1999) The WASH study (warfarin/aspirin study in heart failure) rationale, design and end-points. European Journal of Heart Failure, 1(1), pp. 95-99.

1998

Packard, C. , Shepherd, J., Cobbe, S., Ford, I. , Isles, C.G., McKillop, J.H., MacFarlane, P.W., Lorimer, A.R. and Norrie, J. (1998) Influence of pravastatin and plasma lipids on clinical events in the West of Scotland coronary prevention study (WOSCOPS). Circulation, 97(15), pp. 1440-1445.

McDonagh, T., Robb, S.D., Murdoch, D.R., Morton, J.J., Ford, I. , Morrison, C.E., Tunstall-Pedoe, H., McMurray, J. and Dargie, H. (1998) Biochemical detection of left-ventricular systolic dysfunction. Lancet, 351(9095), pp. 9-13. (doi: 10.1016/S0140-6736(97)03034-1)

Ford, I. and Holmes, A.P. (1998) Functional neuroimaging and statistics. In: Everitt, B.S. and Dunn, G. (eds.) In Statistical Analysis of Medical Data: New Developments. Oxford University Press: London, UK, pp. 277-305. ISBN 9780340677759

Gaw, A., Brown, E. and Ford, I. (1998) Impact of Aapo(a) length polymorphism and the control of plasma Lp(a) concentrations: evidence for a threshold effect. Arteriosclerosis, Thrombosis, and Vascular Biology, 18, pp. 1870-1876. (doi: 10.1161/01.ATV.18.12.1870)

1997

Caro, J., Klittoch, W., McGuire, A., Ford, I. , Norrie, J., Pettitt, D., McMurray, J. and Shepherd, J. (1997) The West of Scotland coronary prevention study: economic benefit analysis of primary prevention with pravastatin. British Medical Journal, 315, pp. 1577-1582. (doi: 10.1136/bmj.315.7122.1577)

McDonagh, T.A., Morrison, C.E., Lawrence, A., Ford, I. , Tunstall-Pedoe, H., McMurray, J.J.V. and Dargie, H.J. (1997) Symptomatic and asymptomatic left-ventricular systolic dysfunction in an urban population. Lancet, 350(9081), pp. 829-833. (doi: 10.1016/S0140-6736(97)03033-X)

1996

Patel, D.J., Mulcahy, D., Norrie, J., Wright, C., Clarke, D., Ford, I. and Fox, K.M. (1996) Natural variability of transient myocardial ischaemia during daily life: an obstacle when assessing efficacy of anti-ischaemic agents? Heart, 76, pp. 477-482.

Cobbe, S.M., Dalziel, K., Ford, I. and Marsden, A.K. (1996) Survival of 1476 patients initially resuscitated from out of hospital cardiac arrest. British Medical Journal, 312, pp. 1633-1637. (doi: 10.1136/bmj.312.7047.1633) (PMID:8664715) (PMCID:PMC2351362)

Fox, K.M., Mulcahy, D., Findlay, I., Ford, I. and Dargie, H. (1996) The Total Ischaemic Burden European Trial (TIBET): effects of atenolol, nifedipine SR and their combination on the exercise test and the total ischaemic burden in 608 patients with stable angina. European Heart Journal, 17(1), pp. 96-103.

Fox, K.M., Mulcahy, D., Findlay, I., Ford, I. and Dargie, H. (1996) Total Ischaemic Burden European Trial (TIBET): effects of ischaemia and treatment with atenolol, nifedipine SR and their combination on outcome in patients with chronic stable angina. European Heart Journal, 17(1), pp. 104-112.

Holmes, A.P., Blair, R.C., Watson, J.D. and Ford, I. (1996) Nonparametric analysis of statistic images from functional mapping experiments. Journal of Cerebral Blood Flow and Metabolism, 16, pp. 7-22. (doi: 10.1097/00004647-199601000-00002)

1995

Patel, D.J., Mulcahy, D., Norrie, J., Sparrow, J., Wright, C., Ford, I. and Fox, K.M. (1995) Does the exercise protocol matter when assessing the anti-anginal effects of drug therapy? European Heart Journal, 16(12), pp. 1773-1779.

Shepherd, J., Cobbe, S.M., Ford, I. , Isles, C.G., Lorimer, A.R., Macfarlane, P.W., McKillop, J.H. and Packard, C.J. (1995) Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. New England Journal of Medicine, 333(20), pp. 1301-1308. (doi: 10.1056/NEJM199511163332001)

Ford, I. (1995) Some nonontological and functionally unconnected views on current issues in the analysis of PET datasets. Journal of Cerebral Blood Flow and Metabolism, 15(3), pp. 371-377. (doi: 10.1038/jcbfm.1995.46)

Ford, I. , Norrie, J. and Ahmadi, S. (1995) Model inconsistency, illustrated by Cox proportional hazards model. Statistics in Medicine, 14(8), pp. 735-746. (doi: 10.1002/sim.4780140804)

Martin, B.J., Devine, B.L., MacDonald, J.B., Williams, J., Kiggins, P., Norrie, J. and Ford, I. (1995) Incidence of pressure sores in geriatric long-term hospital care. Journal of Tissue Viability, 5, pp. 83-88.

Metcalfe, M. and Ford, I. (1995) Contribution of perindopril in the treatment of congestive heart failure. Drugs of Today, 31, pp. 39-44.

1994

Ray, S.G., McCann, G., Henderson, E., MacFarlane, N., Christie, J., Norrie, J., Ford, I. , Grant, S. and Dargie, H.J. (1994) Cardiorespiratory and symptomatic variables during maximal and submaximal exercise in men with stable effort angina: a comparison of atenolol and celiprolol. European Heart Journal, 15(11), pp. 1566-1570. (doi: 10.1093/oxfordjournals.eurheartj.a060431) (PMID:7835373)

McColl, J.H. , Holmes, A.P. and Ford, I. (1994) Statistical methods in neuroimaging with particular application to emission tomography. Statistical Methods in Medical Research, 3(1), pp. 63-86.

1993

Ray, S.G., Pye, M., Oldroyd, K.G., Christie, J., Connelly, D., Norhtridge, D., Morton, J.J., Ford, I. , Dargie, H. and Cobbe, S. (1993) Early treatment with Captopril after acute myocardial infarction. British Heart Journal, 69(3), pp. 215-222.

Dargie, H., Fox, K.M. and Ford, I. (1993) Clinical trials in silent ischaemia: lessons from TIBET. Archives de Maladies du Coeur et des Vaisseaux, 86, pp. 31-34.

Graham, D.I., Adams, J.H., Doyle, D., Ford, I. , Gennarelli, T.A., Lawrence, A.E., Maxwell, W.L. and McLean, D.R. (1993) Quantification of primary and secondary lesions in severe head injury. Acta Neurochirurgica: Supplementum, 57, pp. 41-48.

1992

Ford, I. , Torsney, B. and Wu, C.F.J. (1992) The use of a canonical form in the construction of locally optimal designs for non-linear problems. Journal of the Royal Statistical Society: Series B (Statistical Methodology), 54(2), pp. 569-583.

1991

McCrory, S.J. and Ford, I. (1991) Multivariate analysis of SPECT images with illustrations in Alzheimer's disease. Statistics in Medicine, 10(11), pp. 1711-1718.

Oldroyd, K.G., Pye, M.P., Ray, S.G., Christie, J., Ford, I. , Cobbe, S.M. and Dargie, H.J. (1991) Effects of early Captopril administration on infarct expansion, left ventricular remodelling and exercise capacity after acute myocardial infarction. American Journal of Cardiology, 68(8), pp. 713-718. (doi: 10.1016/0002-9149(91)90641-W)

Ford, I. , McColl, J.H. , McCormack, A.G. and McCrory, S.J. (1991) Statistical issues in the analysis of neuroimages. Journal of Cerebral Blood Flow and Metabolism, 11(2), A89-A95.

McLenachan, J.M., Grant, S., Ford, I. , Henderson, E. and Dargie, H.J. (1991) Submaximal, but not maximal, exercise testing detects differences in the effects of beta-blockers during tredmill excerise: a study of Celiprolol and Atenolol. American Heart Journal, 121(2), pp. 691-696.

Ford, I. (1991) Angina clinical trial methodology. Postgraduate Medical Journal, 67(Sup 3), S2-S8.

Kerr, W.J.S. and Ford, I. (1991) The variability of some craniofacial dimensions. Angle Orthodontist, 61(3), pp. 205-210.

Kotapka, M.J., Gennarelli, T.A., Graham, D.I., Adams, J.H., Thibault, L.E., Ross, D.T. and Ford, I. (1991) Selective vulnerability of hippocampal neurons in acceleration-induced experimental head injury. Journal of Neurotrauma, 8(4), pp. 247-258.

1990

Pickard, M.A., Venner, R.M., Ford, I. and Todd, B.D. (1990) The influence of immediate physiotherapy in the out-patient management of acute knee injuries: a controlled study. Archives of Emergency Medicine, 7(4), pp. 249-252.

Northbridge, D.B., Grant, S., Ford, I. , Christie, J., McLenachan, J., Connelly, D., McMurray, J., Ray, S., Henderson, E. and Dargie, H.J. (1990) Novel exercise protocol suitable for use on a treadmill or a bicycle ergometer. British Heart Journal, 64(5), pp. 313-316.

Hirst, D.J., Ford, I. and Critchley, F. (1990) An empirical investigation of methods for interval estimation of the log odds ratio in discriminant analysis. Biometrika, 77(3), pp. 609-615.

1989

Adams, J.H., Doyle, D., Ford, I. , Gennarelli, T.A., Graham, D.I. and McLellan, D.R. (1989) Diffuse axonal injury in head injury: definition, diagnosis and grading. Histopathology, 15(1), pp. 49-59. (doi: 10.1111/j.1365-2559.1989.tb03040.x)

Adams, J.H., Doyle, D., Ford, I. , Graham, D.I., McGee, M. and McLellan, D.R. (1989) Brain damage in fatal non-missile head injury in relation to age and type of injury. Scottish Medical Journal, 34(1), pp. 399-401.

Graham, D.I., Ford, I. , Adams, J.H., Doyle, D., Lawerence, A.E. and McLellan, D.R. (1989) Fatal head injury in children. Journal of Clinical Pathology, 42(1), pp. 18-22.

Graham, D.I., Ford, I. , Adams, J.H., Doyle, D., Teasdale, F.M., Lawrence, A.E. and McLellan, D.R. (1989) Ischaemic brain damage is still common in fatal non-missile head injury. Journal of Neurology, Neurosurgery and Psychiatry, 52(3), pp. 346-350. (doi: 10.1136/jnnp.52.3.346)

McColl, J.H. , Ford, I. , McGhee, M.A., Brooks, D.N. and Murphy, J.B. (1989) Referal patterns of elderly patients with dementia or depression. Health Bulletin, 47(6), pp. 273-281.

Ng, T., Graham, D.I., Adams, J.H. and Ford, I. (1989) Changes in the hippocampus and the cerebellum resulting from hypoxic insults: frequency & distribution. Acta Neuropathologica, 78(4), pp. 438-443. (doi: 10.1007/BF00688181)

1988

Critchley, F., Ford, I. and Rijal, O. (1988) Interval estimation based on the profile likelihood: strong Lagrangrain theory, with applications to discrimination. Biometrika, 75(1), pp. 21-28.

1987

Dargie, H.J., Cleland, J.G.F., Leckie, B.J., Inglis, G.G., East, B.W. and Ford, I. (1987) The relation of arythmmias and electrolyte abnormalities to survival in patients with severe chronic heart failure. Circulation, 75(5), pp. 98-107.

Osbourne, K.A., Shigeno, T., Balarsky, A.M., Ford, I. , McCulloch, J., Teasdale, G.M. and Graham, D.I. (1987) Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia. Journal of Neurology, Neurosurgery and Psychiatry, 50(4), pp. 402-410.

Cleland, J.G., Dargie, H.J. and Ford, I. (1987) Mortality in heart failure: clinical variables of prognostic value. British Heart Journal, 58(6), pp. 572-582.

1986

Wrona, F.J., Calow, P., Ford, I. , Baird, D.J. and Maltby, L. (1986) Estimating the abundance of stone dwelling organisms: A new method. Canadian Journal of Fisheries and Aquatic Sciences, 43(10), pp. 2025-2035. (doi: 10.1139/f86-248)

Kelly, P.A.T., Ford, I. and McCulloch, J. (1986) The effect of diazepam upon local cerebral glucose use in the conscious rat. Neuroscience, 19(1), pp. 257-265. (doi: 10.1016/0306-4522(86)90019-9)

Ford, I. (1986) Confunded correlations: statistical limitations in the analysis of interregional relationships of cerebral metabolic activity. Journal of Cerebral Blood Flow and Metabolism, 6(3), pp. 385-388.

Kerr, W.J.S. and Ford, I. (1986) A comparison of facial form in three Western European male groups. European Journal of Orthodontics, 8(2), pp. 106-111.

1985

Cleland, J.G.F., Dargie, H., McAlpine, H., Ball, S.G., Morton, J.J., Robertson, J.I.S. and Ford, I. (1985) Severe hypotension after 1st dose of Enalapril in heart failure. British Medical Journal, 291(6505), pp. 1309-1312.

Cleland, J.G.F., Dargie, H., Ball, S.G., Gillen, G., Hodsman, G.P., Morton, J.J., East, B.W., Robertson, I., Ford, I. and Robertson, J.I.S. (1985) Effects of Enalapril in heart failure: a double blind study of effects on exercise performance, renal function, hormones and metabolic state. Heart, 54(3), pp. 305-312.

Critchley, F. and Ford, I. (1985) Interval estimation in discrimination: the multivariate normal equal covariance case. Biometrika, 72(1), pp. 109-116. (doi: 10.2307/2336340)

Ford, I. , Titterington, D. and Wu, C.F.J. (1985) Inference and sequential design. Biometrika, 72(3), pp. 545-551. (doi: 10.2307/2336726)

1984

Critchley, F. and Ford, I. (1984) On the covariance of 2 noncentral F-random variable and the variance of the estimated linear discriminant function. Biometrika, 71(3), pp. 637-368. (doi: 10.2307/2336578)

Cleland, J., Semple, P., Ball, S., Ford, I. , Dargie, H. and Hodsman, P. (1984) Angiotensin II levels, hemodynamics and sympathoadrenal function after low-dose Captopril in heart failure. American Journal of Medicine, 77(5), pp. 880-886. (doi: 10.1016/0002-9343(84)90530-8)

1983

Smith, N., Soutter, W.P., Sharp, F., McColl, J. and Ford, I. (1983) Fetal scalp blood lactate as an indicator of intrapartum hypoxia. British Journal of Obstetrics and Gynaecology, 90(9), pp. 821-831. (doi: 10.1111/j.1471-0528.1983.tb09322.x)

1982

McCulloch, J., Kelly, P.A.T. and Ford, I. (1982) Effect of Apomorphine on the relationship between local cerebral glucose-utilization and local cerebral blood-flow (with an appendix on its statistical-analysis). Journal of Cerebral Blood Flow and Metabolism, 2(4), pp. 487-499. (doi: 10.1038/jcbfm.1982.56)

1980

Ford, I. and Silvey, S.D. (1980) A sequentially constructed design for estimating a nonlinear parametric function. Biometrika, 67(2), pp. 381-388. (doi: 10.1093/biomet/67.2.381)

Articles

Muir, K. et al. (2024) Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurology, 23(11), pp. 1087-1096. (doi: 10.1016/S1474-4422(24)00377-6)

Foley, P.W. et al. (2024) Effect of correcting iron deficiency on the risk of serious infection in heart failure insights from the IRONMAN trial. European Journal of Heart Failure, (doi: 10.1002/ejhf.3504) (PMID:39453738) (Early Online Publication)

Lee, M. et al. (2024) Administration of ferric derisomaltose for iron deficiency and heart failure during hospital admission or at the clinic – insights from the IRONMAN trial. European Journal of Heart Failure, 26(10), pp. 2293-2295. (doi: 10.1002/ejhf.3394) (PMID:39078467)

Cleland, J. et al. (2024) The IRONMAN trial of intravenous iron for heart failure. Adjudication of hospitalizations and deaths. Journal of the American College of Cardiology, (Accepted for Publication)

Docherty, K. F. , McMurray, J. J.V. , Kalra, P., Cleland, J. G.F. , Lang, N. N. , Petrie, M. C. , Robertson, M. and Ford, I. (2024) Intravenous iron and SGLT2 inhibitors in iron-deficient patients with heart failure and reduced ejection fraction. ESC Heart Failure, 11(4), pp. 1875-1879. (doi: 10.1002/ehf2.14742) (PMID:38549192) (PMCID:PMC11287326)

Roger, G. et al. (2024) Chronic coronary syndromes without standard modifiable cardiovascular risk factors and outcomes: the CLARIFY registry. European Heart Journal, 45(27), pp. 2396-2406. (doi: 10.1093/eurheartj/ehae299)

Hageman, S. H..J. et al. (2024) Prediction of individual lifetime cardiovascular risk and potential treatment benefit: development and recalibration of the LIFE-CVD2 model to four European risk regions. European Journal of Preventive Cardiology, (doi: 10.1093/eurjpc/zwae174) (PMID:38752762) (Early Online Publication)

Ray, R. et al. (2024) The impact of ferric derisomaltose on cardiovascular and non-cardiovascular events in patients with anemia, iron deficiency and heart failure with reduced ejection fraction. Journal of Cardiac Failure, 30(5), pp. 682-690. (doi: 10.1016/j.cardfail.2023.10.006) (PMID:37926238) (PMCID:PMC11096866)

Cleland, J. G.F. et al. (2024) Intravenous iron for heart failure, iron deficiency definitions, and clinical response: the IRONMAN trial. European Heart Journal, 45(16), pp. 1410-1426. (doi: 10.1093/eurheartj/ehae086) (PMID:38446126) (PMCID:PMC11032711)

Suzuki, K. et al. (2024) Genetic drivers of heterogeneity in type 2 diabetes pathophysiology. Nature, 627(8003), pp. 347-357. (doi: 10.1038/s41586-024-07019-6) (PMID:38374256)

Mackenzie, I. S. et al. (2024) Allopurinol and cardiovascular outcomes in patients with ischaemic heart disease: the ALL-HEART RCT and economic evaluation. Health Technology Assessment, 28(18), pp. 1-55. (doi: 10.3310/ATTM4092) (PMID:38551218)

MacKenzie, R. M. et al. (2024) Clinical outcomes and adverse events of bariatric surgery in adults with severe obesity in Scotland: the SCOTS observational cohort study. Health Technology Assessment, 28(7), (doi: 10.3310/UNAW6331)

Stähli, B. E. et al. (2023) Timing of complete revascularization with multivessel PCI for myocardial infarction. New England Journal of Medicine, 389(15), pp. 1368-1379. (doi: 10.1056/NEJMoa2307823) (PMID:37634190)

Abdin, A., Komajda, M., Borer, J. S., Ford, I. , Tavazzi, L., Batailler, C., Swedberg, K., Rosano, G. M.C., Mahfoud, F. and Böhm, M. (2023) Efficacy of ivabradine in heart failure patients with a high-risk profile (analysis from the SHIFT trial). ESC Heart Failure, 10(5), pp. 2895-2902. (doi: 10.1002/ehf2.14455) (PMID:37427483) (PMCID:PMC10567656)

Abtan, J. et al. (2023) Association between coffee or tea consumption and cardiovascular outcomes in patients with stable coronary artery disease: Analysis from the CLARIFY registry. Archives of Cardiovascular Diseases, 116(8-9), pp. 382-389. (doi: 10.1016/j.acvd.2023.05.007) (PMID:37524628)