Dr Anthony Manyara
- Honorary Research Fellow (School of Health & Wellbeing)
email:
Anthony.Manyara@glasgow.ac.uk
Musculoskeletal Research Unit, University of Bristol, Level 1 Learning and Research Building, Southmead Hospital
Biography
I joined the Complexity in Health Improvement Programme at the MRC/CSO Social and Public Health Sciences Unit in November 2021. My role involves coordinating the SPIRIT|CONSORT-SURROGATE project.
My background is in public health having obtained a BSc (First class) in Environmental Health from Moi University, MSc (with Distinction) in Public Health from UWE Bristol, and PhD in Social and Public Health science from the University of Glasgow.
I worked previously in research positions at APHRC, UWE Bristol, KEMRI Wellcome Trust and Aquaya Institute.
Research interests
- Noncommunicable disease prevention
- Mixed methods studies
- Theory of change development
- Surrogate endpoints
- Health systems and policy research
Publications
2024
Taylor, R. S. , Manyara, A. M. , Ross, J. S. and Ciani, O. (2024) Surrogate end points in trials—SPIRIT and CONSORT extensions. JAMA: Journal of the American Medical Association, 332(16), pp. 1340-1342. (doi: 10.1001/jama.2024.15219) (PMID:39102315)
Manyara, A. M. , Purvis, A., Ciani, O., Collins, G. S. and Taylor, R. S. (2024) Sample size in multistakeholder Delphi surveys: at what minimum sample size do replicability of results stabilise? Journal of Clinical Epidemiology, 174, 111485. (doi: 10.1016/j.jclinepi.2024.111485) (PMID:39069013)
Manyara, A. M. , Ciani, O. and Taylor, R. (2024) Transparent and complete reporting of surrogate endpoints in trials: the SPIRIT-and CONSORT-Surrogate extensions. Lancet, 404(10450), pp. 322-324. (doi: 10.1016/S0140-6736(24)01306-0) (PMID:39004089)
Manyara, A. M. et al. (2024) Reporting of surrogate endpoints in randomised controlled trial protocols (SPIRIT-Surrogate): extension checklist with explanation and elaboration. British Medical Journal, 386, e078525. (doi: 10.1136/bmj-2023-078525) (PMID:38981624) (PMCID:PMC11231880)
Manyara, A. M. et al. (2024) Reporting of surrogate endpoints in randomised controlled trial reports (CONSORT-Surrogate): extension checklist with explanation and elaboration. British Medical Journal, 386, e078524. (doi: 10.1136/bmj-2023-078524) (PMID:38981645) (PMCID:PMC11231881)
Richert, L., Manyara, A. , Ciani, O. and Taylor, R. (2024) Présentation des Critères de Substitution dans les Publications d'Essais Contrôlés Randomisés: Élaboration et Explication de l'Extension CONSORT-Surrogate 202323. EPICLIN 2024, 18ème Conférence francophone d’Épidémiologie Clinique, 31èmes journées des statisticiens des centres de lutte contre le cancer, Dijon, France, 15-17 May 2024. p. 202444. (doi: 10.1016/j.jeph.2024.202444)
Christensen, R., Ciani, O., Manyara, A. M. and Taylor, R. S. (2024) Low-density lipoprotein cholesterol is not a successful surrogate endpoint: author’s reply. Journal of Clinical Epidemiology, 171, 111389. (doi: 10.1016/j.jclinepi.2024.111389) (PMID:38723781)
Manyara, A. , Mwanik, E., Gill, J. M.R. and Gray, C. M. (2024) Knowledge, perceptions, and practices towards diabetes risk in sub-Saharan Africa: a mixed methods scoping review. Public Health Nutrition, 27(1), e104. (doi: 10.1017/S1368980024000752) (PMID:38533768) (PMCID:PMC11010065)
Manyara, A. M. , Mwaniki, E., Gill, J. M.R. and Gray, C. M. (2024) Perceptions of diabetes risk and prevention in Nairobi, Kenya: a qualitative and theory of change development study. PLoS ONE, 19(2), e0297779. (doi: 10.1371/journal.pone.0297779) (PMID:38349938) (PMCID:PMC10863861)
2023
Ciani, O. et al. (2023) A framework for the definition and interpretation of the use of surrogate endpoints in interventional trials. EClinicalMedicine, 65, 102283. (doi: 10.1016/j.eclinm.2023.102283) (PMID:37877001) (PMCID:PMC10590868)
Manyara, A. M. et al. (2023) Definitions, acceptability, limitations, and guidance in the use and reporting of surrogate endpoints in trials: a scoping review. Journal of Clinical Epidemiology, 160, pp. 83-99. (doi: 10.1016/j.jclinepi.2023.06.013) (PMID:37380118)
2022
Ciani, O., Manyara, A. M. , Chen, A.-W. and Taylor, R. S. (2022) Surrogate endpoints in trials: a call for better reporting. Trials, 23, 991. (doi: 10.1186/s13063-022-06904-7) (PMID:36503559) (PMCID:PMC9743760)
Manyara, A. M. et al. (2022) Completeness in reporting of surrogate primary endpoints in Randomised Controlled Trials: A targeted review protocol. [Protocols]
Ciani, O., Manyara, A. M. and Taylor, R. S. (2022) Surrogate endpoints in cardio-thoracic trials: a call for better reporting and improved interpretation of trial findings. European Journal of Cardio-Thoracic Surgery, 62(4), ezac449. (doi: 10.1093/ejcts/ezac449) (PMID:36112148)
Manyara, A. , Davies, P., Stewart, D., Wells, V. , Weir, C., Young, A., Taylor, R. and Ciani, O. (2022) Scoping and targeted reviews to support development of SPIRIT and CONSORT extensions for randomised controlled trials with surrogate primary endpoints: protocol. BMJ Open, 12(10), e062798. (doi: 10.1136/bmjopen-2022-062798) (PMID:36229145) (PMCID:PMC9562307)
Manyara, A. M. et al. (2022) Protocol for the development of SPIRIT and CONSORT extensions for randomised controlled trials with surrogate primary endpoints: SPIRIT-SURROGATE and CONSORT-SURROGATE. BMJ Open, 12(10), e064304. (doi: 10.1136/bmjopen-2022-064304) (PMID:36220321) (PMCID:PMC9557267)
Ciani, O., Manyara, A. M. and Taylor, R. S. (2022) Need for better reporting of trials with surrogate endpoints – SPIRIT|CONSORT-SURROGATE extensions. Journal of Epidemiology and Community Health, 76(9), pp. 769-770. (doi: 10.1136/jech-2022-219294) (PMID:35750481) (PMCID:PMC9380472)
Ciani, O., Manyara, A. M. and Taylor, R. S. (2022) Surrogate endpoints in trials – a call for better reporting. British Medical Journal, 378, o1912. (doi: 10.1136/bmj.o1912) (PMID:35905986)
Manyara, A. M. , Ciani, O. and Taylor, R. S. (2022) A call for better reporting of trials using surrogate primary endpoints. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 8(1), e12340. (doi: 10.1002/trc2.12340) (PMID:35910671) (PMCID:PMC9323346)
Polašek, O. et al. (2022) Research priorities to reduce the impact of COVID-19 in low- and middle-income countries. Journal of Global Health, 12, 09003. (doi: 10.7189/jogh.12.09003) (PMID:35475006) (PMCID:PMC9010705)
Manyara, A. M. , Ciani, O. and Taylor, R. S. (2022) Reply to Commentary by Cummings (2022): Surrogate endpoints extend beyond biomarkers. Alzheimer's and Dementia, 8(1), e12344. (doi: 10.1002/trc2.12344) (PMID:35910664) (PMCID:PMC9323349)
2021
Manyara, A. M. , Mwaniki, E., Gray, C. M. and Gill, J. M.R. (2021) Comparison of risk factors between people with type 2 diabetes and matched controls in Nairobi, Kenya. Tropical Medicine and International Health, 26(9), pp. 1075-1087. (doi: 10.1111/tmi.13629) (PMID:34051023)
Manyara, A. M. (2021) Optimal cut-offs of five anthropometric indices and their predictive ability of type 2 diabetes in a nationally representative Kenyan study. AIMS Public Health, 8(3), pp. 507-518. (doi: 10.3934/publichealth.2021041) (PMID:34395701) (PMCID:PMC8334637)
2019
Improving Health in Slums Collaborative, (2019) A protocol for a multi-site, spatially-referenced household survey in slum settings: methods for access, sampling frame construction, sampling, and field data collection. BMC Medical Research Methodology, 19, 109. (doi: 10.1186/s12874-019-0732-x) (PMID:31146676) (PMCID:PMC6543601)
2018
Manyara, A. M. , Buunaaisie, C., Annett, H., Bird, E., Bray, I., Ige, J., Jones, M., Orme, J., Pilkington, P. and Evans, D. (2018) Exploring the multidisciplinary extent of public health career structures in 12 countries: an exploratory mapping. Journal of Public Health, 40(4), e538-e544. (doi: 10.1093/pubmed/fdy057) (PMID:29590452)
Buunaaisie, C., Manyara, A.M. , Annett, H., Bird, E.L., Bray, I., Ige, J., Jones, M., Orme, J., Pilkington, P. and Evans, D. (2018) Employability and career experiences of international graduates of MSc Public Health: a mixed methods study. Public Health, 160, pp. 62-69. (doi: 10.1016/j.puhe.2018.03.032) (PMID:29751223)
2017
Barasa, E. W., Manyara, A. M. , Molyneux, S. and Tsofa, B. (2017) Recentralization within decentralization: county hospital autonomy under devolution in Kenya. PLoS ONE, 12(8), e0182440. (doi: 10.1371/journal.pone.0182440) (PMID:28771558) (PMCID:PMC5542634)
Articles
Taylor, R. S. , Manyara, A. M. , Ross, J. S. and Ciani, O. (2024) Surrogate end points in trials—SPIRIT and CONSORT extensions. JAMA: Journal of the American Medical Association, 332(16), pp. 1340-1342. (doi: 10.1001/jama.2024.15219) (PMID:39102315)
Manyara, A. M. , Purvis, A., Ciani, O., Collins, G. S. and Taylor, R. S. (2024) Sample size in multistakeholder Delphi surveys: at what minimum sample size do replicability of results stabilise? Journal of Clinical Epidemiology, 174, 111485. (doi: 10.1016/j.jclinepi.2024.111485) (PMID:39069013)
Manyara, A. M. , Ciani, O. and Taylor, R. (2024) Transparent and complete reporting of surrogate endpoints in trials: the SPIRIT-and CONSORT-Surrogate extensions. Lancet, 404(10450), pp. 322-324. (doi: 10.1016/S0140-6736(24)01306-0) (PMID:39004089)
Manyara, A. M. et al. (2024) Reporting of surrogate endpoints in randomised controlled trial protocols (SPIRIT-Surrogate): extension checklist with explanation and elaboration. British Medical Journal, 386, e078525. (doi: 10.1136/bmj-2023-078525) (PMID:38981624) (PMCID:PMC11231880)
Manyara, A. M. et al. (2024) Reporting of surrogate endpoints in randomised controlled trial reports (CONSORT-Surrogate): extension checklist with explanation and elaboration. British Medical Journal, 386, e078524. (doi: 10.1136/bmj-2023-078524) (PMID:38981645) (PMCID:PMC11231881)
Christensen, R., Ciani, O., Manyara, A. M. and Taylor, R. S. (2024) Low-density lipoprotein cholesterol is not a successful surrogate endpoint: author’s reply. Journal of Clinical Epidemiology, 171, 111389. (doi: 10.1016/j.jclinepi.2024.111389) (PMID:38723781)
Manyara, A. , Mwanik, E., Gill, J. M.R. and Gray, C. M. (2024) Knowledge, perceptions, and practices towards diabetes risk in sub-Saharan Africa: a mixed methods scoping review. Public Health Nutrition, 27(1), e104. (doi: 10.1017/S1368980024000752) (PMID:38533768) (PMCID:PMC11010065)
Manyara, A. M. , Mwaniki, E., Gill, J. M.R. and Gray, C. M. (2024) Perceptions of diabetes risk and prevention in Nairobi, Kenya: a qualitative and theory of change development study. PLoS ONE, 19(2), e0297779. (doi: 10.1371/journal.pone.0297779) (PMID:38349938) (PMCID:PMC10863861)
Ciani, O. et al. (2023) A framework for the definition and interpretation of the use of surrogate endpoints in interventional trials. EClinicalMedicine, 65, 102283. (doi: 10.1016/j.eclinm.2023.102283) (PMID:37877001) (PMCID:PMC10590868)
Manyara, A. M. et al. (2023) Definitions, acceptability, limitations, and guidance in the use and reporting of surrogate endpoints in trials: a scoping review. Journal of Clinical Epidemiology, 160, pp. 83-99. (doi: 10.1016/j.jclinepi.2023.06.013) (PMID:37380118)
Ciani, O., Manyara, A. M. , Chen, A.-W. and Taylor, R. S. (2022) Surrogate endpoints in trials: a call for better reporting. Trials, 23, 991. (doi: 10.1186/s13063-022-06904-7) (PMID:36503559) (PMCID:PMC9743760)
Ciani, O., Manyara, A. M. and Taylor, R. S. (2022) Surrogate endpoints in cardio-thoracic trials: a call for better reporting and improved interpretation of trial findings. European Journal of Cardio-Thoracic Surgery, 62(4), ezac449. (doi: 10.1093/ejcts/ezac449) (PMID:36112148)
Manyara, A. , Davies, P., Stewart, D., Wells, V. , Weir, C., Young, A., Taylor, R. and Ciani, O. (2022) Scoping and targeted reviews to support development of SPIRIT and CONSORT extensions for randomised controlled trials with surrogate primary endpoints: protocol. BMJ Open, 12(10), e062798. (doi: 10.1136/bmjopen-2022-062798) (PMID:36229145) (PMCID:PMC9562307)
Manyara, A. M. et al. (2022) Protocol for the development of SPIRIT and CONSORT extensions for randomised controlled trials with surrogate primary endpoints: SPIRIT-SURROGATE and CONSORT-SURROGATE. BMJ Open, 12(10), e064304. (doi: 10.1136/bmjopen-2022-064304) (PMID:36220321) (PMCID:PMC9557267)
Ciani, O., Manyara, A. M. and Taylor, R. S. (2022) Need for better reporting of trials with surrogate endpoints – SPIRIT|CONSORT-SURROGATE extensions. Journal of Epidemiology and Community Health, 76(9), pp. 769-770. (doi: 10.1136/jech-2022-219294) (PMID:35750481) (PMCID:PMC9380472)
Ciani, O., Manyara, A. M. and Taylor, R. S. (2022) Surrogate endpoints in trials – a call for better reporting. British Medical Journal, 378, o1912. (doi: 10.1136/bmj.o1912) (PMID:35905986)
Manyara, A. M. , Ciani, O. and Taylor, R. S. (2022) A call for better reporting of trials using surrogate primary endpoints. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 8(1), e12340. (doi: 10.1002/trc2.12340) (PMID:35910671) (PMCID:PMC9323346)
Polašek, O. et al. (2022) Research priorities to reduce the impact of COVID-19 in low- and middle-income countries. Journal of Global Health, 12, 09003. (doi: 10.7189/jogh.12.09003) (PMID:35475006) (PMCID:PMC9010705)
Manyara, A. M. , Ciani, O. and Taylor, R. S. (2022) Reply to Commentary by Cummings (2022): Surrogate endpoints extend beyond biomarkers. Alzheimer's and Dementia, 8(1), e12344. (doi: 10.1002/trc2.12344) (PMID:35910664) (PMCID:PMC9323349)
Manyara, A. M. , Mwaniki, E., Gray, C. M. and Gill, J. M.R. (2021) Comparison of risk factors between people with type 2 diabetes and matched controls in Nairobi, Kenya. Tropical Medicine and International Health, 26(9), pp. 1075-1087. (doi: 10.1111/tmi.13629) (PMID:34051023)
Manyara, A. M. (2021) Optimal cut-offs of five anthropometric indices and their predictive ability of type 2 diabetes in a nationally representative Kenyan study. AIMS Public Health, 8(3), pp. 507-518. (doi: 10.3934/publichealth.2021041) (PMID:34395701) (PMCID:PMC8334637)
Improving Health in Slums Collaborative, (2019) A protocol for a multi-site, spatially-referenced household survey in slum settings: methods for access, sampling frame construction, sampling, and field data collection. BMC Medical Research Methodology, 19, 109. (doi: 10.1186/s12874-019-0732-x) (PMID:31146676) (PMCID:PMC6543601)
Manyara, A. M. , Buunaaisie, C., Annett, H., Bird, E., Bray, I., Ige, J., Jones, M., Orme, J., Pilkington, P. and Evans, D. (2018) Exploring the multidisciplinary extent of public health career structures in 12 countries: an exploratory mapping. Journal of Public Health, 40(4), e538-e544. (doi: 10.1093/pubmed/fdy057) (PMID:29590452)
Buunaaisie, C., Manyara, A.M. , Annett, H., Bird, E.L., Bray, I., Ige, J., Jones, M., Orme, J., Pilkington, P. and Evans, D. (2018) Employability and career experiences of international graduates of MSc Public Health: a mixed methods study. Public Health, 160, pp. 62-69. (doi: 10.1016/j.puhe.2018.03.032) (PMID:29751223)
Barasa, E. W., Manyara, A. M. , Molyneux, S. and Tsofa, B. (2017) Recentralization within decentralization: county hospital autonomy under devolution in Kenya. PLoS ONE, 12(8), e0182440. (doi: 10.1371/journal.pone.0182440) (PMID:28771558) (PMCID:PMC5542634)
Conference or Workshop Item
Richert, L., Manyara, A. , Ciani, O. and Taylor, R. (2024) Présentation des Critères de Substitution dans les Publications d'Essais Contrôlés Randomisés: Élaboration et Explication de l'Extension CONSORT-Surrogate 202323. EPICLIN 2024, 18ème Conférence francophone d’Épidémiologie Clinique, 31èmes journées des statisticiens des centres de lutte contre le cancer, Dijon, France, 15-17 May 2024. p. 202444. (doi: 10.1016/j.jeph.2024.202444)
Protocols
Manyara, A. M. et al. (2022) Completeness in reporting of surrogate primary endpoints in Randomised Controlled Trials: A targeted review protocol. [Protocols]