These Cochrane reviews have played a pivotal role in informing evidence-based policy both in the United Kingdom and internationally and have been cited in key clinical guidelines and quality standards including:

• European Society of Cardiology ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation (2020)

• European Society of Cardiology ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease (2020)

• European Society of Cardiology ESC Guidelines for the diagnosis and management of chronic coronary syndromes (2019)

• National Institute for Health and Care Excellence (NICE) NG106 Chronic heart failure in adults: diagnosis and management (2018)

• ESC/EACTS Guidelines on myocardial revascularization (2018)

• Scottish Intercollegiate Guidelines Network (SIGN) 150 Cardiac Rehabilitation (2017) 

• Scottish Intercollegiate Guidelines Network (SIGN) 147 Management of chronic heart failure (2017)

• European Society of Cardiology Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation (2017)

• European Society of Cardiology Guidelines for the diagnosis and treatment of acute and chronic heart failure (2016)

• European Guidelines on cardiovascular disease prevention in clinical practice (2016)

• Contributory risk and management of comorbidities in chronic heart failure (American Heart Association, 2016)

• Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association (2016)

• American Heart Association Guideline for the Management of Patients with Non-ST-Elevation Acute Coronary Syndromes (2014)

• ACC/AHA/SCAI/AMA–Convened PCPI/NCQA Performance Measures for Adults Undergoing Percutaneous Coronary Intervention (2014) 

In addition, by identifying current evidence gaps, these reviews have played a role in informing the commissioning of research with three notable examples:

• Rehabilitation Enablement in Chronic Heart Failure (REACH-HF) programme:
  REACH-HF aims to develop a new self-help manual for people with heart failure and their caregivers that may help them to manage the condition using the principles of cardiac rehabilitation. The team will then evaluate the clinical effectiveness, cost effectiveness and acceptability of the manual for people with heart failure and their caregivers. 
• CADENCE:
  A feasibility study and pilot RCT to establish methods for assessing the acceptability, and clinical and cost-effectiveness of enhanced psychological care (EPC) in cardiac rehabilitation services for patients with new onset depression compared with treatment as usual: CADENCE
• ExTraMATCH II: Exercise-based rehabilitation for chronic heart failure:
  Exercise Training for Chronic Heart Failure ExTraMATCH II is an international collaboration which aims to undertake a comprehensive review of contemporary RCT evidence in order to investigate the relationship between exercise training in Heart Failure (HF) and exercise capacity.  Using individual participant data (IPD) meta-analysis, the information gained from ExTraMATCH II will inform future clinical and policy decision-making on the use of exercise-based interventions in HF.

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