Drawing on a comprehensive overview of published evidence spanning – and encompassing 990 randomised controlled trials and over 900,000 patients – the research underscores the fundamental role of exercise in enhancing the wellbeing of individuals living with long-term health conditions.

Conducted by researchers at the University of Glasgow in collaboration with the University of Leicester, University of Birmingham, University of Exeter, University of Salford, University of York, and Trinity College Dublin, the latest study is published in eClinicalMedicine.

Chronic disease is one the major challenges facing international healthcare systems, with almost half of the global population suffering from at least one long-term health condition. Defined as conditions for which there is currently no known cure, long-term health conditions are instead managed through a combination of drugs and non-pharmaceutical treatments, including exercise programmes. While medication can abate symptoms, exercise programmes have been shown to have an impact on people’s physical and mental health, with positive effects on cardiovascular and respiratory health as well as mood and general wellbeing.

In this study, the researchers found that participation in exercise programmes leads to consistent improvements in exercise capacity as well as enhanced quality of life across a broad spectrum of long-term conditions. However, there remained some areas of uncertainty, including the impact of exercise programmes on mortality and hospitalisation rates for people with long-term conditions.

Researchers argue the findings of the study indicate the need for healthcare services to adopt approaches that consider the importance of targeted exercise interventions for people who have one or more long-term health conditions.

Dr Grace Dibben, lead researcher of the study from the MRC/CSO Social and Public Health Sciences Unit, said: “Almost half of the global population live with at least one long-term condition, which results in substantial health and socioeconomic burden. Our findings underscore the urgent need for healthcare systems to integrate exercise interventions into the management of long-term conditions, to better address the diverse needs of individuals living with a wider range of long-term conditions.”

The study is part of the PERFORM (Personalised Exercise-Rehabilitation For people with Multiple long-term conditions (multimorbidity)) trial, which aims to co-develop (with patients, caregivers, clinicians and service commissioners) a bespoke programme of personalised exercise-based rehabilitation for people with multimorbidity.

The study, Evidence for Exercise-Based Interventions across 45 Different Long-Term Conditions: An Overview of Systematic Reviews, is published in eClinicalMedicine. The work was funded by the National Institute for Health and Care Research.

First published: 29 April 2024

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