Multimorbidity literature update May to August 2022

Multimorbidity literature update 1.5.22 - 30.8.22‌

Wagner, C., Carmeli, C., Chiolero, A. and Cullati, S. (2022). Life Course Socioeconomic Conditions and Multimorbidity in Old Age – A Scoping Review. Ageing Research Reviews, p.101630. doi:10.1016/j.arr.2022.101630.

‌Aramrat, C., Choksomngam, Y., Jiraporncharoen, W., Wiwatkunupakarn, N., Pinyopornpanish, K., Mallinson, P.A.C., Kinra, S. and Angkurawaranon, C. (2022). Advancing multimorbidity management in primary care: a narrative review. Primary Health Care Research & Development, 23. doi:10.1017/s1463423622000238.

Sinha, A., Kerketta, S., Ghosal, S., Kanungo, S. and Pati, S. (2022). Multimorbidity Among Urban Poor in India: Findings From LASI, Wave-1. Frontiers in Public Health, [online] 10, p.881967. doi:10.3389/fpubh.2022.881967.

Correction: Prevalence and predictors of medication non-adherence among people living with multimorbidity: a systematic review and meta-analysis. (2022). BMJ Open, 12(7), p.e044987corr1. doi:10.1136/bmjopen-2020-044987corr1.

van den Akker, M., Dieckelmann, M., Hussain, M.A., Bond-Smith, D., Muth, C., Pati, S., Saxena, S., Silva, D., Skoss, R., Straker, L., Thompson, S.C. and Katzenellenbogen, J.M. (2022). Children and adolescents are not small adults: toward a better understanding of multimorbidity in younger populations. Journal of Clinical Epidemiology, [online] pp.S0895-4356(22)001767. doi:10.1016/j.jclinepi.2022.07.003.

Ferro, M.A., Qureshi, S., Van Lieshout, R.J., Lipman, E.L., Georgiades, K., Gorter, J.W., Timmons, B.W. and Shanahan, L. (2022). Prevalence and Correlates of Physical-mental Multimorbidity in Outpatient Children From a Pediatric Hospital in Canada. Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie, [online] 67(8), pp.626–637. doi:10.1177/07067437221074430.

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Ismail, S., Stanley, A. and Jeemon, P. (2022). Prevalence of multimorbidity and associated treatment burden in primary care settings in Kerala: a cross-sectional study in Malappuram District, Kerala, India. Wellcome Open Research, [online] 7, p.67. doi:10.12688/wellcomeopenres.17674.2.

‌Lin, W.-Q., Yuan, L.-X., Sun, M.-Y., Wang, C., Liang, E.-M., Li, Y.-H., Liu, L., Yang, Y.-O., Wu, D., Lin, G.-Z. and Liu, H. (2022). Prevalence and patterns of multimorbidity in chronic diseases in Guangzhou, China: a data mining study in the residents’ health records system among 31 708 community-dwelling elderly people. BMJ open, [online] 12(5), p.e056135. doi:10.1136/bmjopen-2021-056135.

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Zhang, Q., Han, X., Zhao, X. and Wang, Y. (2022). Multimorbidity patterns and associated factors in older Chinese: results from the China health and retirement longitudinal study. BMC geriatrics, [online] 22(1), p.470. doi:10.1186/s12877-022-03154-9.

‌Jones, R.E., Tasnim, L. and Cunningham, S.A. (2022). The Prevalence of Multimorbidity among Foreign-born Adults in the United States. Ethnicity & Disease, [online] 32(3), pp.213–222. doi:10.18865/ed.32.3.213.

Sturmer, J., Franken, D.L., Ternus, D.L., Henn, R.L., Soares Dias-da-Costa, J., Anselmo Olinto, M.T. and Vieira Paniz, V.M. (2022). Dietary patterns and prevalence of multimorbidity in women in southern Brazil. Menopause (New York, N.Y.), [online] 29(9), pp.1047–1054. doi:10.1097/GME.0000000000002023.

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Keomma, K., Bousquat, A. and César, C.L.G. (2022). Prevalência de multimorbidade em idosos em São Paulo, Brasil: um estudo com o ISA-Capital. Revista de Saúde Pública, 56, p.69. doi:10.11606/s1518-8787.2022056004252.

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Han, B.H. and Palamar, J.J. (2021). Multimorbidity Among US Adults Who Use Methamphetamine, 2015–2019. Journal of General Internal Medicine. doi:10.1007/s11606-021-06910-6.

Willadsen, T.G., Siersma, V., Nicolaisdóttir, D.R., Køster-Rasmussen, R., Reventlow, S. and Rozing, M. (2022). The effect of disease onset chronology on mortality among patients with multimorbidity: A Danish nationwide register study. Journal of Multimorbidity and Comorbidity, [online] 12, p.26335565221122025. doi:10.1177/26335565221122025.

Carrasco-Ribelles, L.A., Roso-Llorach, A., Cabrera-Bean, M., Costa-Garrido, A., Zabaleta-Del-Olmo, E., Toran-Monserrat, P., Orfila Pernas, F. and Violán, C. (2022). Dynamics of multimorbidity and frailty, and their contribution to mortality, nursing home and home care need: A primary care cohort of 1 456 052 ageing people. EClinicalMedicine, [online] 52, p.101610. doi:10.1016/j.eclinm.2022.101610.

Schuttner, L., Hockett Sherlock, S., Simons, C.E., Johnson, N.L., Wirtz, E., Ralston, J.D., Rosland, A.-M., Nelson, K. and Sayre, G. (2022). My Goals Are Not Their Goals: Barriers and Facilitators to Delivery of Patient-Centered Care for Patients with Multimorbidity. Journal of General Internal Medicine. doi:10.1007/s11606-022-07533-1.

‌Shang, X., Zhang, X., Huang, Y., Zhu, Z., Zhang, X., Liu, J., Wang, W., Tang, S., Yu, H., Ge, Z., Yang, X. and He, M. (2022). Association of a wide range of individual chronic diseases and their multimorbidity with brain volumes in the UK Biobank: A cross-sectional study. EClinicalMedicine, [online] 47, p.101413. doi:10.1016/j.eclinm.2022.101413.

‌Li, G., Lu, Y., Qiao, Y., Hu, D. and Ke, C. (2022). Role of Pulmonary Function in Predicting New-Onset Cardiometabolic Diseases and Cardiometabolic Multimorbidity. Chest. doi:10.1016/j.chest.2021.12.663.

Caballero, F.F., Lana, A., Struijk, E.A., Arias-Fernández, L., Yévenes-Briones, H., Cárdenas-Valladolid, J., Salinero-Fort, M.Á., Banegas, J.R., Rodríguez-Artalejo, F. and Lopez-Garcia, E. (2022). Prospective Association Between Plasma Amino Acids And Multimorbidity In Older Adults. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, [online] p.glac144. doi:10.1093/gerona/glac144.

Liu, H., Zhang, X., Chen, B., Fang, B., Lou, V.W.Q. and Hu, J. (2022). The Differential Impact of Multimorbidity Patterns and Subsequent Accumulation on Longitudinal Trajectories of Physical Function Decline in a Population-Based Cohort of Older People. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, [online] 77(8), pp.1629–1636. doi:10.1093/gerona/glab384.

‌Ho, H.-E., Yeh, C.-J., Wei, J.C.-C., Chu, W.-M. and Lee, M.-C. (2022). Multimorbidity patterns and their relationships with incident disability and frailty among older adults in Taiwan: A 16-year, population-based cohort study. Archives of Gerontology and Geriatrics, [online] 101, p.104688. doi:10.1016/j.archger.2022.104688.

Hariri, P., Clarke, R., Bragg, F., Chen, Y., Guo, Y., Yang, L., Lv, J., Yu, C., Li, L., Chen, Z., Bennett, D.A. and China Kadoorie Biobank Collaborative Group (2022). Frequency and types of clusters of major chronic diseases in 0.5 million adults in urban and rural China. Journal of Multimorbidity and Comorbidity, [online] 12, p.26335565221098327. doi:10.1177/26335565221098327.

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Kato, D., Kawachi, I. and Kondo, N. (2022). Complex Multimorbidity and Working beyond Retirement Age in Japan: A Prospective Propensity-Matched Analysis. International Journal of Environmental Research and Public Health, [online] 19(11), p.6553. doi:10.3390/ijerph19116553.

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Oliveira, F.E.G., Griep, R.H., Chor, D., Giatti, L., Machado, L.A.C., Barreto, S.M., da Costa Pereira, A., Fonseca, M. de J.M. da and Bastos, L.S. (2022). Racial inequalities in multimorbidity: baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). BMC public health, [online] 22(1), p.1319. doi:10.1186/s12889-022-13715-7.

Zhou, J., Wei, M.Y., Zhang, J., Liu, H. and Wu, C. (2022). Association of multimorbidity patterns with incident disability and recovery of independence among middle-aged and older adults. Age and Ageing, [online] 51(8), p.afac177. doi:10.1093/ageing/afac177.

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Luo, Y., He, L., Ma, T., Li, J., Bai, Y., Cheng, X. and Zhang, G. (2022). Associations between consumption of three types of beverages and risk of cardiometabolic multimorbidity in UK Biobank participants: a prospective cohort study. BMC medicine, [online] 20(1), p.273. doi:10.1186/s12916-022-02456-4.

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Pati, S., Sinha, A., Ghosal, S., Kerketta, S., Lee, J.T. and Kanungo, S. (2022). Family-Level Multimorbidity among Older Adults in India: Looking through a Syndemic Lens. International Journal of Environmental Research and Public Health, [online] 19(16), p.9850. doi:10.3390/ijerph19169850.

Gurgel do Amaral, G.S., Ots, P., Brouwer, S. and van Zon, S.K.R. (2022). Multimorbidity and exit from paid employment: the effect of specific combinations of chronic health conditions. European Journal of Public Health. doi:10.1093/eurpub/ckac018.

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Knies, G. and Kumari, M. (2022). Multimorbidity is associated with the income, education, employment and health domains of area-level deprivation in adult residents in the UK. Scientific Reports, [online] 12(1), p.7280. doi:10.1038/s41598-022-11310-9.

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Keetile, M., Letamo, G. and Navaneetham, K. (2022). The influence of childhood socioeconomic status on non-communicable disease risk factor clustering and multimorbidity among adults in Botswana: a life course perspective. International Health. doi:10.1093/inthealth/ihac026.

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Roomaney, R.A., van Wyk, B., Cois, A. and Pillay-van Wyk, V. (2022). One in five South Africans are multimorbid: An analysis of the 2016 demographic and health survey. PLOS ONE, 17(5), p.e0269081. doi:10.1371/journal.pone.0269081.

‌Grundy, E.M. and Stuchbury, R. (2022). Multimorbidity as assessed by reporting of multiple causes of death: variations by period, sociodemographic characteristics and place of death among older decedents in England and Wales, 2001-2017. Journal of Epidemiology and Community Health, [online] p.jech–2021-217846. doi:10.1136/jech-2021-217846.

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Jääskeläinen, T., Koponen, P., Lundqvist, A., Suvisaari, J., Järvelin, J. and Koskinen, S. (2022). Study protocol for an epidemiological study ‘Multimorbidity - identifying the most burdensome patterns, risk factors and potentials to reduce future burden (MOLTO)’ based on the Finnish health examination surveys and the ongoing register-based follow-up. BMJ open, [online] 12(6), p.e056073. doi:10.1136/bmjopen-2021-056073.

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Han, S., Mo, G., Gao, T., Sun, Q., Liu, H. and Zhang, M. (2022). Age, sex, residence, and region-specific differences in prevalence and patterns of multimorbidity among older Chinese: evidence from Chinese Longitudinal Healthy Longevity Survey. BMC public health, [online] 22(1), p.1116. doi:10.1186/s12889-022-13506-0.

Puri, P., Singh, S.K. and Pati, S. (2022). Identifying non-communicable disease multimorbidity patterns and associated factors: a latent class analysis approach. BMJ open, [online] 12(7), p.e053981. doi:10.1136/bmjopen-2021-053981.

Catalao, R., Dorrington, S., Pritchard, M., Jewell, A., Broadbent, M., Ashworth, M., Hatch, S. and Howard, L. (2022). Ethnic inequalities in mental and physical multimorbidity in women of reproductive age: a data linkage cohort study. BMJ open, [online] 12(7), p.e059257. doi:10.1136/bmjopen-2021-059257.

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Lv, J., Li, R., Yuan, L., Yang, X., Wang, Y., Ye, Z.-W. and Huang, F.-M. (2022). Research on the frailty status and adverse outcomes of elderly patients with multimorbidity. BMC Geriatrics, 22(1). doi:10.1186/s12877-022-03194-1.

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Han, E.-J., Song, M.K. and Lee, Y. (2022). The 10-year multimorbidity trajectory and mortality risk in older people with long-term care needs. Archives of Gerontology and Geriatrics, 103, p.104775. doi:10.1016/j.archger.2022.104775.

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Tran, P.B., Kazibwe, J., Nikolaidis, G.F., Linnosmaa, I., Rijken, M. and van Olmen, J. (2022). Costs of multimorbidity: a systematic review and meta-analyses. BMC Medicine, 20(1). doi:10.1186/s12916-022-02427-9.

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Batista, S.R., Sousa, A.L.L., Nunes, B.P., Silva, R.R., Jardim, P.C.B.V. and Brazilian Group of Studies on Multimorbidity (GBEM) (2022). Identifying multimorbidity clusters among Brazilian older adults using network analysis: Findings and perspectives. PloS One, [online] 17(7), p.e0271639. doi:10.1371/journal.pone.0271639.

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Kabir, A., Tran, A., Ansari, S., Conway, D.P. and Barr, M. (2022). Impact of multimorbidity and complex multimorbidity on mortality among older Australians aged 45 years and over: a large population-based record linkage study. BMJ Open, [online] 12(7), p.e060001. doi:10.1136/bmjopen-2021-060001.

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Rojas-Huerta, A., Giraldo-Rodríguez, L., Agudelo-Botero, M. and Mino-León, D. (2022). Differences by Sex in the Presentation of Multimorbidity: Longitudinal Study in Mexican Adults Living in the Community, 2001–2018. Journal of Women’s Health. doi:10.1089/jwh.2021.0599.

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Kim, J., Baek, Y., Jeong, K. and Lee, S. (2022). Association of Dietary Factors With Grip Strength, Body Fat, and Prevalence of Sarcopenic Obesity in Rural Korean Elderly With Cardiometabolic Multimorbidity. Frontiers in Nutrition, [online] 9, p.910481. doi:10.3389/fnut.2022.910481.

Jungo, K.T., Cheval, B., Sieber, S., Antonia van der Linden, B.W., Ihle, A., Carmeli, C., Chiolero, A., Streit, S. and Cullati, S. (2022). Life-course socioeconomic conditions, multimorbidity and polypharmacy in older adults: A retrospective cohort study. PloS One, [online] 17(8), p.e0271298. doi:10.1371/journal.pone.0271298.

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Zou, S., Wang, Z. and Tang, K. (2022). Social inequalities in all-cause mortality among adults with multimorbidity: a 10-year prospective study of 0.5 million Chinese adults. International Health, [online] p.ihac052. doi:10.1093/inthealth/ihac052.

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Li, D., Wang, L., Zhou, Z., Song, L., Chen, S., Yang, Y., Hu, Y., Wang, Y., Wu, S. and Tian, Y. (2022). Role of socioeconomic, lifestyle, and clinical factors in the progression of cardiometabolic multimorbidity in China: A 10-year prospective cohort study. Nutrition, metabolism, and cardiovascular diseases: NMCD, [online] pp.S0939-4753(22)002812. doi:10.1016/j.numecd.2022.06.016.

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Ioakeim-Skoufa, I., Clerencia-Sierra, M., Moreno-Juste, A., Elías de Molins Peña, C., Poblador-Plou, B., Aza-Pascual-Salcedo, M., González-Rubio, F., Prados-Torres, A. and Gimeno-Miguel, A. (2022). Multimorbidity Clusters in the Oldest Old: Results from the EpiChron Cohort. International Journal of Environmental Research and Public Health, [online] 19(16), p.10180. doi:10.3390/ijerph191610180.

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Gupta, P., Patel, S.A., Sharma, H., Jarhyan, P., Sharma, R., Prabhakaran, D., Tandon, N. and Mohan, S. (2022). Burden, patterns, and impact of multimorbidity in North India: findings from a rural population-based study. BMC public health, [online] 22(1), p.1101. doi:10.1186/s12889-022-13495-0.

Lenti, M.V., Klersy, C., Brera, A.S., Ballesio, A., Croce, G., Padovini, L., Ciccocioppo, R., Bertolino, G., Di Sabatino, A. and Corazza, G.R. (2022). Aging underlies heterogeneity between comorbidity and multimorbidity frameworks. Internal and Emergency Medicine. doi:10.1007/s11739-021-02899-2.

Aubert, C.E., Rodondi, N., Netzer, S., Dalleur, O., Spinewine, A., Maanen, C.D., Knol, W., O’Mahony, D., Aujesky, D. and Donzé, J. (2022). Predictors of 1-year drug-related admissions in older multimorbid hospitalized adults. Journal of the American Geriatrics Society, [online] 70(5), pp.1510–1516. doi:10.1111/jgs.17667.

Coatsworth‐Puspoky, R., Dahlke, S., Duggleby, W. and Hunter, Kathleen F. (2022). Older persons with multiple chronic conditions’ experiences of unplanned readmission: An integrative review. International Journal of Older People Nursing. doi:10.1111/opn.12481.

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Rodrigues, L.P., Vissoci, J.R.N., França, D.G., Caruzzo, N.M., Batista, S.R.R., de Oliveira, C., Nunes, B.P. and Silveira, E.A. (2022). Multimorbidity patterns and hospitalisation occurrence in adults and older adults aged 50 years or over. Scientific Reports, [online] 12(1), p.11643. doi:10.1038/s41598-022-15723-4.

Rodrigues, L.P., de Oliveira Rezende, A.T., Delpino, F.M., Mendonça, C.R., Noll, M., Nunes, B.P., de Oliviera, C. and Silveira, E.A. (2022). Association between multimorbidity and hospitalization in older adults: systematic review and meta-analysis. Age and Ageing, 51(7). doi:10.1093/ageing/afac155.

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Ahmed, A., Khan, H.T.A. and Lawal, M. (2022). Effective Hospital Care Delivery Model for Older People in Nigeria with Multimorbidity: Recommendations for Practice. Healthcare (Basel, Switzerland), [online] 10(7), p.1268. doi:10.3390/healthcare10071268.

Morales-Puerto, M., Ruiz-Díaz, M., Aranda-Gallardo, M., Morales-Asencio, J.M., Alcalá-Gutiérrez, P., Rodríguez-Montalvo, J.A., León-Campos, Á., García-Mayor, S. and Canca-Sánchez, J.C. (2022). Development of a Clinical Prediction Rule for Adverse Events in Multimorbid Patients in Emergency and Hospitalisation. International Journal of Environmental Research and Public Health, [online] 19(14), p.8581. doi:10.3390/ijerph19148581.

Litchfield, I., Kingston, B., Narga, D. and Turner, A. (2022). The move towards integrated care: Lessons learnt from managing patients with multiple morbidities in the UK. Health Policy (Amsterdam, Netherlands), [online] 126(8), pp.777–785. doi:10.1016/j.healthpol.2022.05.010.

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‌Pati, S., Pati, S., Puri, P., Sinha, R. and Panda, M. (2022). Profile of comorbidity and multimorbidity among women attending antenatal clinics: An exploratory cross-sectional study from Odisha, India. Journal of Family Medicine and Primary Care, 11(5), p.1980. doi:10.4103/jfmpc.jfmpc_1855_21.

Jennings, E.L.M., O’Mahony, D. and Gallagher, P.F. (2021). Medication-related quality of life (MRQoL) in ambulatory older adults with multi-morbidity and polypharmacy. European Geriatric Medicine. doi:10.1007/s41999-021-00573-6.

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O’Loughlin, R., Hiscock, H., Pan, T., Devlin, N. and Dalziel, K. (2022). The relationship between physical and mental health multimorbidity and children’s health-related quality of life. Quality of Life Research. doi:10.1007/s11136-022-03095-1.

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Chamberlain, A.M., St Sauver, J.L., Boyd, C.M., Finney Rutten, L.J., Fan, C., Jacobson, D.J. and Rocca, W.A. (2022). Multi-morbidity and patient-reported functional limitations: a population-based cohort study. Journal of Multimorbidity and Comorbidity, 12, p.263355652211054. doi:10.1177/26335565221105448.

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Paukkonen, L., Oikarinen, A., Kähkönen, O. and Kaakinen, P. (2022). Patient activation for self-management among adult patients with multimorbidity in primary healthcare settings. Health Science Reports, [online] 5(4), p.e735. doi:10.1002/hsr2.735.

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Van Wilder, L., Devleesschauwer, B., Clays, E., Pype, P., Vandepitte, S. and De Smedt, D. (2022). Polypharmacy and Health-Related Quality of Life/Psychological Distress Among Patients With Chronic Disease. Preventing Chronic Disease, 19. doi:10.5888/pcd19.220062.

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Wu, Y.-T., Kingston, A., Houlden, V. and Franklin, R. (2022). The longitudinal associations between proximity to local grocery shops and functional ability in the very old living with and without multimorbidity: Results from the Newcastle 85+ study. Archives of Gerontology and Geriatrics, 101, p.104703. doi:10.1016/j.archger.2022.104703.

Cheng, C., Yang, C., Inder, K. and Chan, S.W. (2021). Psychometric properties of Brief Coping Orientation to Problems Experienced in patients with multiple chronic conditions: A preliminary study. International Journal of Nursing Practice. doi:10.1111/ijn.12955.

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Gan, D.R.Y., Wister, A.V. and Best, J.R. (2022). Environmental Influences on Life Satisfaction and Depressive Symptoms Among Older Adults with Multimorbidity: Path Analysis Through Loneliness in the Canadian Longitudinal Study on Aging. The Gerontologist. doi:10.1093/geront/gnac004.

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Yin, J., Ma, T., Li, J., Zhang, G., Cheng, X. and Bai, Y. (2022). Association of mood disorder with cardiometabolic multimorbidity trajectory and life expectancy, a prospective cohort study. Journal of Affective Disorders, [online] 312, pp.1–8. doi:10.1016/j.jad.2022.06.003.

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Langer, N., Plomecka, M.B., Tröndle, M., Negi, A., Popov, T., Milham, M. and Haufe, S. (2022). A benchmark for prediction of psychiatric multimorbidity from resting EEG data in a large pediatric sample. NeuroImage, [online] 258, p.119348. doi:10.1016/j.neuroimage.2022.119348.

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Smith, L., Shin, J.I., Haro, J.M., Jacob, L., López Sánchez, G.F., Tully, M.A., Oh, H., Carvalho, A.F., Barnett, Y., Butler, L. and Koyanagi, A. (2022). Physical multimorbidity and wish to die among adults aged ≥65 years: A cross-sectional analysis of the Irish Longitudinal Study on Ageing. Journal of Affective Disorders, [online] 313, pp.263–269. doi:10.1016/j.jad.2022.06.063.

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Molist-Brunet, N., Sevilla-Sánchez, D., Puigoriol-Juvanteny, E., Barneto-Soto, M., González-Bueno, J. and Espaulella-Panicot, J. (2022). Improving individualized prescription in patients with multimorbidity through medication review. BMC Geriatrics, 22(1). doi:10.1186/s12877-022-03107-2.

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Franchi, C., Ludergnani, M., Merlino, L., Nobili, A., Fortino, I., Leoni, O. and Ardoino, I. (2022). Multiple Medication Adherence and Related Outcomes in Community-Dwelling Older People on Chronic Polypharmacy: A Retrospective Cohort Study on Administrative Claims Data. International Journal of Environmental Research and Public Health, 19(9), p.5692. doi:10.3390/ijerph19095692.

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Allaham, K., Feyasa, M.B., Govender, R.D., Musa, A., AlKaabi, A.J., ElBarazi, I., AlSheryani, S.D., Al Falasi, R.J. and Khan, M.A. (2022). Medication Adherence Among Patients with Multimorbidity in the United Arab Emirates. Patient Preference and Adherence, Volume 16, pp.1187–1200. doi:10.2147/ppa.s355891.

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Brooks, C.F., Argyropoulos, A., Matheson-Monnet, C.B. and Kryl, D. (2022). Evaluating the impact of a polypharmacy Action Learning Sets tool on healthcare practitioners’ confidence, perceptions and experiences of stopping inappropriate medicines. BMC medical education, [online] 22(1), p.499. doi:10.1186/s12909-022-03556-8.

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Randles, M.A., O’Mahony, D. and Gallagher, P.F. (2022). Frailty and Potentially Inappropriate Prescribing in Older People with Polypharmacy: A Bi-Directional Relationship? Drugs & Aging, [online] 39(8), pp.597–606. doi:10.1007/s40266-022-00952-z.

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Hughes, C.M. (2022). One size fits all? How to optimize the prescribing of appropriate polypharmacy in chronic diseases, using a behavioral approach - a United Kingdom perspective. Expert Review of Clinical Pharmacology, [online] 15(5), pp.497–499. doi:10.1080/17512433.2022.2094767.

Reeve, J., Maden, M., Hill, R., Turk, A., Mahtani, K., Wong, G., Lasserson, D., Krska, J., Mangin, D., Byng, R., Wallace, E. and Ranson, E. (2022). Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis. Health Technology Assessment (Winchester, England), [online] 26(32), pp.1–148. doi:10.3310/AAFO2475.

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Schmidt, M.G., Franken, D.L., Olinto, M.T.A., da Costa, J.S.D. and Paniz, V.M.V. (2022). Impact of multimorbidity on the use of sleep medications among women: a population-based study in Southern Brazil. Sleep & Breathing = Schlaf & Atmung. [online] doi:10.1007/s11325-022-02672-5.

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Patel, S., Kumar, M., Beavers, C.J., Karamat, S. and Alenezi, F. (2022). Polypharmacy and Cardiovascular Diseases: Consideration for Older Adults and Women. Current Atherosclerosis Reports. doi:10.1007/s11883-022-01055-1.

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Marmamula, S., Kumbham, T.R., Shidhaye, R., Modepalli, S.B., Barrenkala, N.R., Yellapragada, R. and Keeffe, J. (2022). Multimorbidity and multi-disability among the elderly in residential care in India: the Hyderabad Ocular Morbidity in Elderly Study (HOMES). Scientific Reports, [online] 12(1), p.11779. doi:10.1038/s41598-022-15943-8.

‌Lozano-Hernández, C.M., López-Rodríguez, J.A., Rico-Blázquez, M., Calderón-Larrañaga, A., Leiva-Fernández, F., Prados-Torres, A., Del Cura-González, I. and MULTIPAP GROUP (2022). Sex differences in social support perceived by polymedicated older adults with multimorbidity. MULTIPAP study. PloS One, [online] 17(7), p.e0268218. doi:10.1371/journal.pone.0268218.

Ansari, A.A., Mahmood, S.B.Z., Afzal, A., Yasmin, A., Tariq, M. and Almas, A. (2022). Rise in Multimorbidity in Internal Medicine Patients: a Longitudinal Study from a Tertiary Care Center in Karachi, Pakistan. Journal of General Internal Medicine. doi:10.1007/s11606-021-07386-0.

Rosen, C.B., Wirtalla, C., Keele, L.J., Roberts, S.E., Kaufman, E.J., Holena, D.N., Halpern, S.D. and Kelz, R.R. (2022). Multimorbidity Confers Greater Risk for Older Patients in Emergency General Surgery Than the Presence of Multiple Comorbidities: A Retrospective Observational Study. Medical Care, [online] 60(8), pp.616–622. doi:10.1097/MLR.0000000000001733.

Onder, G., Vetrano, D.L., Palmer, K., Trevisan, C., Amato, L., Berti, F., Campomori, A., Catalano, L., Corsonello, A., Kruger, P., Medea, G., Nobili, A., Trifirò, G., Vecchi, S., Veronese, N. and Marengoni, A. (2022). Italian guidelines on management of persons with multimorbidity and polypharmacy. Aging Clinical and Experimental Research, [online] 34(5), pp.989–996. doi:10.1007/s40520-022-02094-z.

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Del Cura-González, I., López-Rodríguez, J.A., Leiva-Fernández, F., Gimeno-Miguel, A., Poblador-Plou, B., López-Verde, F., Lozano-Hernández, C., Pico-Soler, V., Bujalance-Zafra, M.J., Gimeno-Feliu, L.A., Aza-Pascual-Salcedo, M., Rogero-Blanco, M., González-Rubio, F., García-de-Blas, F., Polentinos-Castro, E., Sanz-Cuesta, T., Castillo-Jimena, M., Alonso-García, M., Calderón-Larrañaga, A. and Valderas, J.M. (2022). How to Improve Healthcare for Patients with Multimorbidity and Polypharmacy in Primary Care: A Pragmatic Cluster-Randomized Clinical Trial of the MULTIPAP Intervention. Journal of Personalized Medicine, [online] 12(5), p.752. doi:10.3390/jpm12050752.

‌Yang, C., Lee, D.T.F., Wang, X. and Chair, S.Y. (2022). Effects of a nurse-led medication self-management intervention on medication adherence and health outcomes in older people with multimorbidity: A randomised controlled trial. International Journal of Nursing Studies, 134, p.104314. doi:10.1016/j.ijnurstu.2022.104314.

‌Schweda, S., Munz, B., Burgstahler, C., Niess, A.M., Roesel, I., Sudeck, G. and Krauss, I. (2022). Proof of Concept of a 6-Month Person-Oriented Exercise Intervention ‘MultiPill-Exercise’ among Patients at Risk of or with Multiple Chronic Diseases: Results of a One-Group Pilot Trial. International Journal of Environmental Research and Public Health, [online] 19(15), p.9469. doi:10.3390/ijerph19159469.

Mann, C., Jun, G.T., Tyrer, F., Kiani, R., Lewin, G. and Gangadharan, S.K. (2022). A scoping review of clusters of multiple long-term conditions in people with intellectual disabilities and factors impacting on outcomes for this patient group. Journal of Intellectual Disabilities, p.174462952211072. doi:10.1177/17446295221107275.

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Etkind, S.N., Li, J., Louca, J., Hopkins, S.A., Kuhn, I., Spathis, A. and Barclay, S.I.G. (2022). Total uncertainty: a systematic review and thematic synthesis of experiences of uncertainty in older people with advanced multimorbidity, their informal carers and health professionals. Age and Ageing, [online] 51(8), p.afac188. doi:10.1093/ageing/afac188.

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Lutchmun, W., Gach, J., Borup, C. and Froeschl, G. (2022). Chronic diseases and multi-morbidity in persons experiencing homelessness: results from a cross-sectional study conducted at three humanitarian clinics in Germany in 2020. BMC public health, [online] 22(1), p.1597. doi:10.1186/s12889-022-14023-w.

Sader, J., Diana, A., Coen, M., Nendaz, M. and Audétat, M.-C. (2022). A GP’s clinical reasoning in the context of multimorbidity: beyond the perception of an intuitive approach. Family Practice, [online] p.cmac076. doi:10.1093/fampra/cmac076.

‌ Eidam, A., Roth, A., Frick, E., Metzner, M., Lampert, A., Seidling, H., Haefeli, W. and Bauer, J.M. (2022). Development of an Electronic Tool to Assess Patient Preferences in Geriatric Polypharmacy (PolyPref). Patient Preference and Adherence, Volume 16, pp.1733–1747. doi:10.2147/ppa.s364681.

Lai, H.-Y., Huang, S.-T., Chen, L.-K. and Hsiao, F.-Y. (2022). Development of frailty index using ICD-10 codes to predict mortality and rehospitalization of older adults: An update of the multimorbidity frailty index. Archives of Gerontology and Geriatrics, 100, p.104646. doi:10.1016/j.archger.2022.104646.

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Schulze, J., Breckner, A., Duncan, P., Scherer, M., Pohontsch, N.J. and Lühmann, D. (2022). Adaptation and validation of a German version of the Multimorbidity Treatment Burden Questionnaire. Health and Quality of Life Outcomes, 20(1). doi:10.1186/s12955-022-01993-z.

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Dong, G., Zhang, Z.-C., Feng, J. and Zhao, X.-M. (2022). MorbidGCN: prediction of multimorbidity with a graph convolutional network based on integration of population phenotypes and disease network. Briefings in Bioinformatics, [online] 23(4), p.bbac255. doi:10.1093/bib/bbac255.

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McEntee, M.L., Gandek, B. and Ware, J.E. (2022). Improving multimorbidity measurement using individualized disease-specific quality of life impact assessments: predictive validity of a new comorbidity index. Health and Quality of Life Outcomes, [online] 20(1), p.108. doi:10.1186/s12955-022-02016-7.

Gastens, V., Chiolero, A., Anker, D., Schneider, C., Feller, M., Bauer, D.C., Rodondi, N. and Giovane, C.D. (2022). Development and validation of a new prognostic index for mortality risk in multimorbid adults. PloS One, [online] 17(8), p.e0271923. doi:10.1371/journal.pone.0271923. 3.6.

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Roomaney, R.A., van Wyk, B. and Pillay-van Wyk, V. (2022). A systematic method for comparing multimorbidity in national surveys. BMC research notes, [online] 15(1), p.280. doi:10.1186/s13104-022-06164-3. Prevalence [3.1]

Basto-Abreu, A., Barrientos-Gutierrez, T., Wade, A.N., Oliveira de Melo, D., Semeão de Souza, A.S., Nunes, B.P., Perianayagam, A., Tian, M., Yan, L.L., Ghosh, A. and Miranda, J.J. (2022). Multimorbidity matters in low and middle-income countries. Journal of Multimorbidity and Comorbidity, [online] 12, p.26335565221106074. doi:10.1177/26335565221106074.

Multimorbidity. (2022). Nature Reviews Disease Primers, 8(1). doi:10.1038/s41572-022-00383-5.

OUP accepted manuscript. (2022). Journals of Gerontology Series B: Psychological Sciences and Social Sciences. doi:10.1093/geronb/gbac070.

‌Mannheimer, S.M., Bergqvist, M., Bastholm-Rahmner, P., Gustafsson, L.L., Vég, A. and Schmidt-Mende, K. (2022). Home care patients’ experiences from living with polypharmacy - a qualitative interview study. BJGP Open, p.BJGPO.2021.0181. doi:10.3399/bjgpo.2021.0181.

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Brown, E., Poltawski, L., Pitchforth, E., Richards, S., Campbell, J. and Butterworth, J. (2022). Shared decision-making between older people with multimorbidity and GPs: focus group study. British Journal of General Practice, p.BJGP.2021.0529. doi:10.3399/bjgp.2021.0529.

‌Jäger, M., Lindhardt, M.C., Pedersen, J.R., Dideriksen, M., Nyberg, M., Bricca, A., Bodtger, U., Midtgaard, J. and Skou, S.T. (2022). Putting the pieces together: A qualitative study exploring perspectives on self-management and exercise behavior among people living with multimorbidity, healthcare professionals, relatives, and patient advocates. Journal of Multimorbidity and Comorbidity, 12, p.263355652211001. doi:10.1177/26335565221100172.

‌Dinh, T.S., Brueckle, M.-S., González-González, A.I., Witte, J., van den Akker, M., Gerlach, F.M., Muth, C. and On Behalf Of The Evita Study Group (2022). Stakeholder Perspectives on the Development and Implementation of a Polypharmacy Management Program in Germany: Results of a Qualitative Study. Journal of Personalized Medicine, [online] 12(7), p.1115. doi:10.3390/jpm12071115.

‌McAiney, C., Markle-Reid, M., Ganann, R., Whitmore, C., Valaitis, R., Urajnik, D.J., Fisher, K., Ploeg, J., Petrie, P., McMillan, F. and McElhaney, J.E. (2022). Implementation of the Community Assets Supporting Transitions (CAST) transitional care intervention for older adults with multimorbidity and depressive symptoms: A qualitative descriptive study. PLOS ONE, 17(8), p.e0271500. doi:10.1371/journal.pone.0271500.

Tang, J.Y., Lun, P., Teng, P.H.J., Ang, W., Tan, K.T. and Ding, Y.Y. (2022). Intervention elements and behavior change techniques to improve prescribing for older adults with multimorbidity in Singapore: a modified Delphi study. European Geriatric Medicine, [online] 13(3), pp.531–539. doi:10.1007/s41999-021-00566-5.

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Milne-Ives, M., Fraser, L.K., Khan, A., Walker, D., van Velthoven, M.H., May, J., Wolfe, I., Harding, T. and Meinert, E. (2022). Life Course Digital Twins-Intelligent Monitoring for Early and Continuous Intervention and Prevention (LifeTIME): Proposal for a Retrospective Cohort Study. JMIR research protocols, [online] 11(5), p.e35738. doi:10.2196/35738.

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Moreno, A., Moreno, J., Salas, S., González, V., Valido, A., Guardia, P., Luque, L., Reales, A., Machuca, M., Montblanc, E., Garcia, C. and de la Vega, J.M. (2022). CroniCare: Platform for the Design and Implementation of Follow-Up, Control and Self-Management Interventions for Chronic and Multimorbidity Patients Based on Mobile Technologies. Studies in Health Technology and Informatics, [online] 290, pp.1012–1013. doi:10.3233/SHTI220243.

‌Ali, M.U., Sherifali, D., Fitzpatrick-Lewis, D., Kenny, M., Lamarche, L., Raina, P. and Mangin, D. (2022). Interventions to address polypharmacy in older adults living with multimorbidity: Review of reviews. Canadian family physician Medecin de famille canadien, [online] 68(7), pp.e215–e226. doi:10.46747/cfp.6807e215.

‌Skou, S.T., Mair, F.S., Fortin, M., Guthrie, B., Nunes, B.P., Miranda, J.J., Boyd, C.M., Pati, S., Mtenga, S. and Smith, S.M. (2022). Multimorbidity. Nature Reviews Disease Primers, [online] 8(1), pp.1–22. doi:10.1038/s41572-022-00376-4.

McAiney, C., Markle-Reid, M., Ganann, R., Whitmore, C., Valaitis, R., Urajnik, D.J., Fisher, K., Ploeg, J., Petrie, P., McMillan, F. and McElhaney, J.E. (2022). Implementation of the Community Assets Supporting Transitions (CAST) transitional care intervention for older adults with multimorbidity and depressive symptoms: A qualitative descriptive study. PLOS ONE, 17(8), p.e0271500. doi:10.1371/journal.pone.0271500.

‌Carretero-Gómez, J., Pérez-Martínez, P., Seguí-Ripoll, J.M., Carrasco-Sánchez, F.J., Lois Martínez, N., Fernández Pérez, E., Pérez Hernández, O., García Ordoñez, M.Á., Martín González, C., Vigueras-Pérez, J.F., Puchades, F., Blasco Avaria, M.C., Pérez Soto, M.I., Ena, J., Arévalo-Lorido, J.C. and On Behalf Of Diabetes Obesity And Nutrition Working Group Of Spanish Society Of Internal Medicine (2022). High-Risk Obesity Phenotypes: Target for Multimorbidity Prevention at the ROFEMI Study. Journal of Clinical Medicine, [online] 11(16), p.4644. doi:10.3390/jcm11164644.

Schweda, S., Munz, B., Burgstahler, C., Niess, A.M., Roesel, I., Sudeck, G. and Krauss, I. (2022). Proof of Concept of a 6-Month Person-Oriented Exercise Intervention ‘MultiPill-Exercise’ among Patients at Risk of or with Multiple Chronic Diseases: Results of a One-Group Pilot Trial. International Journal of Environmental Research and Public Health, [online] 19(15), p.9469. doi:10.3390/ijerph19159469.

Yang, C., Lee, D.T.F., Wang, X. and Chair, S.Y. (2022). Effects of a nurse-led medication self-management intervention on medication adherence and health outcomes in older people with multimorbidity: A randomised controlled trial. International Journal of Nursing Studies, 134, p.104314. doi:10.1016/j.ijnurstu.2022.104314.

Newsom, J.T., Denning, E.C., Elman, M.R., Botoseneanu, A., Allore, H.G., Nagel, C.L., Dorr, D.A. and Quiñones, A.R. (2022). Physical Activity as a Mediator Between Race/Ethnicity and Changes in Multimorbidity. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences, [online] 77(8), pp.1529–1538. doi:10.1093/geronb/gbab148.

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Alonzo, R., Lalva, T., Couper, R.G. and Wilk, P. (2022). Association between physical activity and life satisfaction among adults with multimorbidity in Canada. Canadian Journal of Public Health. doi:10.17269/s41997-022-00635-7.

Boro, B. and Saikia, N. (2022). Association of multimorbidity and physical activity among older adults in India: an analysis from the Longitudinal Ageing Survey of India (2017-2018). BMJ open, [online] 12(5), p.e053989. doi:10.1136/bmjopen-2021-053989.

Delpino, F.M., de Lima, A.P.M., da Silva, B.G.C., Nunes, B.P., Caputo, E.L. and Bielemann, R.M. (2022). Physical Activity and Multimorbidity Among Community-Dwelling Older Adults: A Systematic Review With Meta-Analysis. American journal of health promotion: AJHP, [online] p.8901171221104458. doi:10.1177/08901171221104458.

Bedard, C., King-Dowling, S., Obeid, J., Timmons, B.W. and Ferro, M.A. (2022). Correlates of Moderate-to-Vigorous Physical Activity in Children With Physical Illness and Physical-Mental Multimorbidity. Health Education & Behavior: The Official Publication of the Society for Public Health Education, [online] p.10901981221100697. doi:10.1177/10901981221100697.

Li, Y., Li, X., Yu, B., Li, J., He, R., Nima, Q. and Zhou, J. (2022). Association between chronic disease multimorbidity and leisure-time physical activity: Evidence from the China Multiethnic Cohort study. Frontiers in Medicine, [online] 9, p.874456. doi:10.3389/fmed.2022.874456.

De Maria, M., Ferro, F., Vellone, E., Ausili, D., Luciani, M. and Matarese, M. (2021). Self‐care of patients with multiple chronic conditions and their caregivers during the COVID‐19 pandemic: A qualitative descriptive study. Journal of Advanced Nursing. doi:10.1111/jan.15115.

‌Correction: Optimising medication management for polymedicated home-dwelling older adults with multiple chronic conditions: a mixed-methods study protocol. (2022). BMJ Open, 12(7), p.e030030corr1. doi:10.1136/bmjopen-2019-030030corr1.

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First published: 10 November 2022

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Multimorbidity literature update May to August 2022