Professor Huabing Yin

Professor of Biomedical Engineering (Biomedical Engineering)

telephone: +44(0)1413304109
email: Huabing.Yin@glasgow.ac.uk

Room 626, Rankine Building, Oakfield Avenue, Glasgow G12 8LT

Research interests

Biography

Dr Yin received her BSc (1992) and MSc (1995) in Chemistry in China. She obtained a PhD (2002) in Chemical Engineering at the University of Wales, Swansea, focusing on nanofiltration membrane development and applications. From 2003 to 2005, she worked as a postdoctoral researcher at the University of Southampton, developing an optical biosensor for gene analysis.

Shortly after joining the University of Glasgow as a postdoctoral researcher, developing microfluidics for high throughput cellular analysis, she was awarded a personal research fellowship from the Royal Society of Edinburgh (2006-2009). After this she was appointed to a lectureship in 2010 and promoted to a senior lecturer in 2011.

Research Interests

My research focuses on developing technologies to understand how a cell, a fundamental unit of life, interacts with its surroundings at the micro-scale; and exploiting this knowledge to benefit health care and the environment. Much of my research converges on micro-/nanofabrication, surface functionalisation, microfluidics and advanced microscopic and spectroscopy technologies. Current activities can be divided into the following themes:

Single-cell analysis: Even in a genetically identical group of cells, individual difference exists. This heterogeneity can dramatically influence cell fate, but is masked when cells are studied using traditional research methods that use average responses from a cell population. We have developed a number of techniques and devices for both mammalian cells and microorganisms, to analyse single cells in a population. These approaches can then be employed to address many topics including drug screening, cancer metastasis, bacterial resistance, and single cell sorting based on Raman signals (i.e. Raman activated cell sorting). The rich information obtained from individuals has led to unprecedented discoveries that significantly advance the knowledge in the field.

Portable devices for diagnosis: Conventional spectroscopic instruments are too bulky to be used in the field. Using advanced nanofabrication technology; we have developed a miniaturised microspectrometer- microfluidic system, capable of performing multiplexing, spectroscopic bioassays in a portable format. This system is of great use in testing samples in resource-limited environments, such as in developing countries or remote industrial plants.

Engineering cellular microenvironments: The interaction between a cell and its environment is influenced by a broad spectrum of physical, chemical and biological cues. Taking a reductionist approach, we are developing microstructured, functional 2D surfaces and 3D biomaterial that resemble key features in the naturally occurring microenvironments, to study cell behaviour in both physiology and pathologic conditions. In collaboration with life scientists and pharmaceutical industries, we are implementing these devices for drug screening, tissue regeneration and cancer research.

Cell mechanics: Physical forces play essential roles in cell functioning, but are difficult to measure at the single cell level. Using Atomic Force Microscopy AFM), we have developed various methods to quantify cell mechanical properties (e.g. stiffness, viscoelasticity) and the interaction forces between cell and matrix. These capabilities, together with our activities in the other themes, provide us a powerful toolbox to develop useful solutions for challenging problems in tissue engineering and cancer research.

Expertise

Microfluidics, optical biosensor, single cell technology, surface patterning, interfaces and biomaterials characterisation, Atomic Force Microscopy on biological samples.

Publications

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Number of items: 117.

2024

Luo, Y., Xua, T., Li, B., Liu, F., Wu, B., Dobson, P. S. , Yin, H. , Chen, Z., Qiu, Y. and Huang, X. (2024) The effects of small plastic particles on antibiotic resistance gene transfer revealed by single cell and community level analysis. Journal of Hazardous Materials, 480, 136271. (doi: 10.1016/j.jhazmat.2024.136271) (PMID:39515144)

Zeng, M. et al. (2024) Dopamine-integrated all-hydrogel multi-electrode arrays for neural activity recording. Materials Horizons, (doi: 10.1039/d4mh00939h) (PMID:39380329) (Early Online Publication)

Peng, Q., Dong, Y., Chen, Y., Glidle, A., Kong, L., Yin, H. , Xu, J. and Yang, K. (2024) Rapid profiling of fish cell nitrogen metabolism with single-cell Raman spectroscopy: unveiling enzyme’s role in ammonia detoxification. Talanta, 277, 1216389. (doi: 10.1016/j.talanta.2024.126389)

Zeng, M. et al. (2024) Phase separation manipulated gradient conductivity for a high-precision flexible pressure sensor. Advanced Functional Materials, (Accepted for Publication)

Zhang, K. et al. (2024) Investigating communication dynamics in neuronal network using 3D gold microelectrode arrays. ACS Nano, 18(26), pp. 17162-17174. (doi: 10.1021/acsnano.4c03983) (PMID:38902594)

Lee, K. S. et al. (2024) MicrobioRaman: an open-access web repository for microbiological Raman spectroscopy data. Nature Microbiology, 9, pp. 1152-1156. (doi: 10.1038/s41564-024-01656-3) (PMID:38714759)

Pu, B., Xiao, G., Xiao, J., Yin, H.-B. and Wang, J. (2024) A strategy for improving self-healing efficiency: application of sensitizer in thymine photoresponsive materials. Polymer, 297, 126844. (doi: 10.1016/j.polymer.2024.126844)

Wei, D., Zeng, M., Su, B., Zhang, Y., Ding, J., Wu, C., Sun, J., Zhou, L., Yin, H. and Fan, H. (2024) Magnetic on-off manipulated matrix mechanic vibration to enhance cell clutches-reinforcement and Ca2+ influx facilitating BMSCs neural differentiation and TBI repair. Chemical Engineering Journal, 484, 149521. (doi: 10.1016/j.cej.2024.149521)

Li, B., Mao, S., Zhang, C., Xu, T., Ma, X., Lin, H., Yin, H. and Qiu, Y. (2024) Rapid anaerobic culture and reaction kinetic study of anammox bacteria on microfluidic chip. Bioresource Technology, 396, 130422. (doi: 10.1016/j.biortech.2024.130422) (PMID:38320714)

Suo, M., Fu, Y., Wang, S., Lin, S., Zhang, J., Wu, C., Yin, H. , Wang, P., Zhang, W. and Wang, X.-H. (2024) Miniaturized laser probe for exosome-based cancer liquid biopsy. Analytical Chemistry, 96(5), pp. 1965-1976. (doi: 10.1021/acs.analchem.3c04187) (PMID:38267074)

Song, Y. , Yin, J., Huang, W. E., Li, B. and Yin, H. (2024) Emerging single-cell microfluidic technology for microbiology. Trends in Analytical Chemistry, 170, 117444. (doi: 10.1016/j.trac.2023.117444)

2023

Li, X., Song, Y. , Chen, X., Yin, J., Wang, P., Huang, H. and Yin, H. (2023) Single-cell microfluidics enabled dynamic evaluation of drug combinations on antibiotic resistance bacteria. Talanta, 265, 124814. (doi: 10.1016/j.talanta.2023.124814)

Hu, J., Bazargan Harandi, H., Chen, Y., Zhang, L., Yin, H. and He, T. (2023) Anisotropic gypsum scaling of corrugated polyvinylidene fluoride hydrophobic membrane in direct contact membrane distillation. Water Research, 244, 120513. (doi: 10.1016/j.watres.2023.120513) (PMID:37651864)

Yang, Y. et al. (2023) PPy/SWCNTs-modified microelectrode array for learning and memory model construction through electrical stimulation and detection of in vitro hippocampal neuronal network. ACS Applied Bio Materials, 6(9), pp. 3414-3422. (doi: 10.1021/acsabm.3c00105) (PMID:37071831)

Zhang, Y. et al. (2023) Magnetic manipulation of Fe₃O₄@BaTiO₃ nanochains to regulate extracellular topographical and electrical cues. Acta Biomaterialia, 168, pp. 470-483. (doi: 10.1016/j.actbio.2023.07.029) (PMID:37495167)

Zhang, Y. et al. (2023) Wireless-powering deep brain stimulation platform based on 1D-structured magnetoelectric nanochains applied in anti-epilepsy treatment. ACS Nano, 17(16), pp. 15796-15809. (doi: 10.1021/acsnano.3c03661)

Yang, X.‐Z. et al. (2023) A‐to‐I RNA editing in Klebsiella pneumoniae regulates quorum sensing and affects cell growth and virulence. Advanced Science, 10(17), 2206056. (doi: 10.1002/advs.202206056) (PMID:37083223) (PMCID:PMC10265045)

Xia, Z., Zhang, X., Yao, J., Liu, Z., Jin, Y., Yin, H. , Wang, P. and Wang, X.-H. (2023) Giant enhancement of Raman scattering by a hollow-core microstructured optical fiber allows single exosome probing. ACS Sensors, 8(4), pp. 1799-1809. (doi: 10.1021/acssensors.3c00131) (PMID:37018734)

Xu, J. et al. (2023) Artificial intelligence-aided rapid and accurate identification of clinical fungal infections by single-cell Raman spectroscopy. Frontiers in Microbiology, 14, 1125676. (doi: 10.3389/fmicb.2023.1125676) (PMID:37032865) (PMCID:PMC10073597)

Intaravanne, Y., Ansari, M. A., Ahmed, H., Bileckaja, N., Yin, H. and Chen, X. (2023) Metasurface-enabled 3-in-1 microscopy. ACS Photonics, 10(2), pp. 544-551. (doi: 10.1021/acsphotonics.2c01971)

Zeng, M.-Z., Wei, D., Ding, J., Tian, Y., Wu, X.-Y., Chen, Z.-H., Wu, C.-H., Sun, J., Yin, H.-B. and Fan, H.-S. (2023) Dopamine induced multiple bonding in hyaluronic acid network to construct particle-free conductive hydrogel for reliable electro-biosensing. Carbohydrate Polymers, 302, 120403. (doi: 10.1016/j.carbpol.2022.120403) (PMID:36604075)

Du, Y. , Stewart, P. , Hill, N. A. , Yin, H. , Penta, R. , Köry, J. , Luo, X. and Ogden, R. (2023) Nonlinear indentation of second-order hyperelastic materials. Journal of the Mechanics and Physics of Solids, 171, 105139. (doi: 10.1016/j.jmps.2022.105139)

Huang, H., Yin, H. and Zhang, X. (2023) Editorial: Engineering probiotics for multiple interventions on intestinal diseases. Frontiers in Cellular and Infection Microbiology, 13, 1138998. (doi: 10.3389/fcimb.2023.1138998) (PMID:36743310) (PMCID:PMC9897589)

2022

Yin, J., Chen, X., Li, X., Kang, G., Wang, P., Song, Y. , Ijaz, U. Z. , Yin, H. and Huang, H. (2022) A droplet-based microfluidic approach to isolating functional bacteria from gut microbiota. Frontiers in Cellular and Infection Microbiology, 12, 920986. (doi: 10.3389/fcimb.2022.920986)

Liu, B., Liu, K., Wang, N., Ta, K., Liang, P., Yin, H. and Li, B. (2022) Laser tweezers Raman spectroscopy combined with deep learning to classify marine bacteria. Talanta, 244, 123383. (doi: 10.1016/j.talanta.2022.123383) (PMID:35349842)

Blomme, A. et al. (2022) THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer. EMBO Molecular Medicine, 14(3), e14764. (doi: 10.15252/emmm.202114764) (PMID:35014179) (PMCID:PMC8899912)

Xu, J., Yi, X., Jin, G., Peng, D., Fan, G., Xu, X., Chen, X., Yin, H. , Cooper, J. M. and Huang, W. E. (2022) High-speed diagnosis of bacterial pathogens at the single cell level by Raman microspectroscopy with machine learning filters and denoising autoencoders. ACS Chemical Biology, 17(2), pp. 376-385. (doi: 10.1021/acschembio.1c00834) (PMID:35026119)

Liu, L., Charlton, L., Song, Y. , Li, T., Li, X., Yin, H. and He, T. (2022) Scaling resistance by fluoro-treatments: the importance of wetting states. Journal of Materials Chemistry A, 10(6), pp. 3058-3068. (doi: 10.1039/D1TA07695G)

Liu, Y., Horseman, T., Wang, Z., Arafat, H. A., Yin, H. , Lin, S. and He, T. (2022) Negative pressure membrane distillation for excellent gypsum scaling resistance and flux enhancement. Environmental Science and Technology, 56(2), pp. 1405-1412. (doi: 10.1021/acs.est.1c07144) (PMID:34941244)

2021

He, E. et al. (2021) SWCNTs/PEDOT:PSS-modified microelectrode arrays for dual-mode detection of electrophysiological signals and dopamine concentration in the striatum under isoflurane anesthesia. ACS Sensors, 6(9), pp. 3377-3386. (doi: 10.1021/acssensors.1c01241) (PMID:34410704)

Nguyen, A. Q., Vu, H. P., Nguyen, L. N., Wang, Q., Djordjevic, S. P., Donner, E., Yin, H. and Nghiem, L. D. (2021) Monitoring antibiotic resistance genes in wastewater treatment: Current strategies and future challenges. Science of the Total Environment, 783, 146964. (doi: 10.1016/j.scitotenv.2021.146964) (PMID:33866168)

Wei, D., Charlton, L., Glidle, A., Qi, N., Dobson, P. S. , Dalby, M. J. , Fan, H. and Yin, H. (2021) Dynamically modulated core-shell microfibers to study the effect of depth sensing of matrix stiffness on stem cell fate. ACS Applied Materials and Interfaces, 13(32), pp. 37997-38006. (doi: 10.1021/acsami.1c06752) (PMID:34355561)

Dai, Y., Song, Y., Xie, J., Xu, S., Li, X., He, E., Yin, H. and Cai, X. (2021) In vivo microelectrode arrays for detecting multi-region epileptic activities in the hippocampus in the latent period of rat model of temporal lobe epilepsy. Micromachines, 12(6), 659. (doi: 10.3390/mi12060659)

Spennati, G., Horowitz, L. F., McGarry, D. J., Rudzka, D. A., Armstrong, G., Olson, M. F., Folch, A. and Yin, H. (2021) Organotypic platform for studying cancer cell metastasis. Experimental Cell Research, 401(2), 112527. (doi: 10.1016/j.yexcr.2021.112527) (PMID:33675807)

Yuan, X. , Glidle, A., Furusho, H. and Yin, H. (2021) A 3D hydrodynamic flow-focusing device for cell sorting. Microfluidics and Nanofluidics, 25(3), 23. (doi: 10.1007/s10404-021-02425-y)

Liu, L., Xiao, Z., Liu, Y., Li, X., Yin, H. , Volkov, A. and He, T. (2021) Understanding the fouling/scaling resistance of superhydrophobic/omniphobic membranes in membrane distillation. Desalination, 499, 114864. (doi: 10.1016/j.desal.2020.114864)

2020

Lyu, Y. , Yuan, X. , Glidle, A., Fu, Y., Furusho, H., Yang, T. and Yin, H. (2020) Automated Raman based cell sorting with 3D microfluidics. Lab on a Chip, 20(22), pp. 4235-4245. (doi: 10.1039/D0LC00679C) (PMID:33057530)

Wang, Y. et al. (2020) Low sample volume origami-paper-based graphene-modified aptasensors for label-free electrochemical detection of cancer biomarker-EGFR. Microsystems and Nanoengineering, 6, 32. (doi: 10.1038/s41378-020-0146-2) (PMID:34567646) (PMCID:PMC8433370)

Liu, Y., Li, Z., Xiao, Z., Yin, H. , Li, X. and He, T. (2020) Synergy of slippery surface and pulse flow: An anti-scaling solution for direct contact membrane distillation. Journal of Membrane Science, 603, 118035. (doi: 10.1016/j.memsci.2020.118035)

Liu, Y., Wang, J., Xiao, Z., Liu, L., Li, D., Li, X., Yin, H. and He, T. (2020) Anisotropic performance of a superhydrophobic polyvinyl difluoride membrane with corrugated pattern in direct contact membrane distillation. Desalination, 481, 114363. (doi: 10.1016/j.desal.2020.114363)

Xiao, Z., Guo, H., He, H., Liu, Y., Li, X., Zhang, Y., Yin, H. , Volkov, A. V. and He, T. (2020) Unprecedented scaling/fouling resistance of omniphobic polyvinylidene fluoride membrane with silica nanoparticle coated micropillars in direct contact membrane distillation. Journal of Membrane Science, 599, 117819. (doi: 10.1016/j.memsci.2020.117819)

2019

Song, Y. , Glidle, A., Quince, C., Collins, G., Sloan, W. and Yin, H. (2019) Single-Cell Microfluidic Platform to Study Anaerobic Bacteria. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2019), Basel, Switzerland, 27-31 Oct 2019.

Li, B., Qiu, Y., Song, Y. , Lin, H. and Yin, H. (2019) Dissecting horizontal and vertical gene transfer of antibiotic resistance plasmid in bacterial community using microfluidics. Environment International, 131, 105007. (doi: 10.1016/j.envint.2019.105007) (PMID:31326825)

Xiao, Z., Li, Z., Gou, H., Liu, Y., Wang, Y., Yin, H. , Li, X., Song, J., Nghiem, L. D. and He, T. (2019) Scaling mitigation in membrane distillation: from superhydrophobic to slippery. Desalination, 466, pp. 36-43. (doi: 10.1016/j.desal.2019.05.006)

Keating, C. , Song, Y. , Ogundero, A., Mathur, N. , Gonzalez-Cabaleiro, R. , Quince, C., Collins, G., Yin, H. and Sloan, W. (2019) Development of a Novel Anaerobic Incubation and Monitoring Platform Embedded with Microfluidics for Real-Time Growth Analysis of Anaerobic Cells. The Gordon Research Seminar on Archaea: Ecology, Metabolism and Molecular Biology, Les Diablerets, Switzerland, 20-21 July 2019.

Wang, Y., Luo, J., Liu, J., Sun, S., Xiong, Y., Ma, Y., Yan, S., Yang, Y., Yin, H. and Cai, X. (2019) Label-free microfluidic paper-based electrochemical aptasensor for ultrasensitive and simultaneous multiplexed detection of cancer biomarkers. Biosensors and Bioelectronics, 136, pp. 84-90. (doi: 10.1016/j.bios.2019.04.032) (PMID:31039491)

Rudzka, D. A. et al. (2019) Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization. Journal of Cell Science, 132(11), jcs224071. (doi: 10.1242/jcs.224071) (PMID:31152052) (PMCID:PMC6589089)

Xiao, Z. et al. (2019) Slippery for scaling resistance in membrane distillation: a novel porous micropillared superhydrophobic surface. Water Research, 155, pp. 152-161. (doi: 10.1016/j.watres.2019.01.036) (PMID:30844676)

Keating, C. , Song, Y. , Ogundero, A., Mathur, N. , Gonzalez-Cabaleiro, R. , Quince, C., Collins, G., Yin, H. and Sloan, W. (2019) Single-Cell Real Time Analysis of the Anaerobic Bacteria Desulfovibrio Vulgaris Demonstrates Population Heterogeneity That Decreases with Increasing pH Stress [Poster]. 8th Congress of European Microbiologists, Glasgow, UK, 07-11 Jul 2019.

Keating, C. , Song, Y. , Ogundero, A., Mathur, N. , Gonzalez-Cabaleiro, R. , Quince, C., Collins, G., Yin, H. and Sloan, W. (2019) Single-Cell Real Time Analysis of the Anaerobic Bacteria Desulfovibrio Vulgaris Demonstrates Population Heterogeneity That Decreases with Increasing pH Stress [Poster]. 16th World Congress on Anaerobic Digestion (AD16), Delft, The Netherlands, 23-27 Jun 2019.

2018

Novo, D. et al. (2018) Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nature Communications, 9, 5069. (doi: 10.1038/s41467-018-07339-y) (PMID:30498210) (PMCID:PMC6265295)

Li, B., Qiu, Y., Zhang, J., Huang, X., Shi, H. and Yin, H. (2018) Real-time study of rapid spread of antibiotic resistance plasmid in biofilm using microfluidics. Environmental Science and Technology, 52(19), pp. 11132-11141. (doi: 10.1021/acs.est.8b03281) (PMID:30179497)

Chim, Y. H., Mason, L. M., Rath, N., Olson, M. F. , Tassieri, M. and Yin, H. (2018) A one-step procedure to probe the viscoelastic properties of cells by Atomic Force Microscopy. Scientific Reports, 8, 14462. (doi: 10.1038/s41598-018-32704-8) (PMID:30262873) (PMCID:PMC6160452)

Yan, W., Wang, X.-H., Yu, J., Meng, X., Qiao, P., Yin, H. , Zhang, Y. and Wang, P. (2018) Precise and label-free tumour cell recognition based on a black phosphorus nanoquenching platform. Journal of Materials Chemistry B, 6(35), pp. 5613-5620. (doi: 10.1039/c8tb01275j)

Yuan, X. et al. (2018) Effect of laser irradiation on cell function and its implications in Raman spectroscopy. Applied and Environmental Microbiology, 84(8), e02508-17. (doi: 10.1128/AEM.02508-17) (PMID:29427427) (PMCID:PMC5881070)

2017

Yuan, X. , Couto, J. M., Glidle, A., Song, Y. , Sloan, W. and Yin, H. (2017) Single-cell microfluidics to study the effects of genome deletion on bacterial growth behavior. ACS Synthetic Biology, 6(12), pp. 2219-2227. (doi: 10.1021/acssynbio.7b00177) (PMID:28844132)

Lyu, Y., Yang, T., Lu, Z., Guo, C., Ge, C., Wang, Z., Jia, D. and Yin, H. (2017) External modulation method for generating accurate linear optical FMCW. IEEE Photonics Technology Letters, 29(18), pp. 1560-1563. (doi: 10.1109/LPT.2017.2736561)

Wang, J., Yu, X., Wang, C., Xiang, K., Deng, M. and Yin, H. (2017) PAMPS/MMT composite hydrogel electrolyte for solid-state supercapacitors. Journal of Alloys and Compounds, 709, pp. 596-601. (doi: 10.1016/j.jallcom.2017.03.157)

Martin, K. C., Yuan, X. , Stimac, G., Bannerman, K., Anderson, J., Roy, C., Glykofrydis, F., Yin, H. and Davies, J. A. (2017) Symmetry-breaking in branching epithelia: cells on micro-patterns under flow challenge the hypothesis of positive feedback by a secreted autocrine inhibitor of motility. Journal of Anatomy, 230(6), pp. 766-774. (doi: 10.1111/joa.12599) (PMID:28369863)

Wei, D., Sun, J., Bolderson, J., Zhong, M., Dalby, M. J. , Cusack, M. , Yin, H. , Fan, H. and Zhang, X. (2017) Continuous fabrication and assembly of spatial cell-laden fibers for a tissue-like construct via a photolithographic-based microfluidic chip. ACS Applied Materials and Interfaces, 9(17), pp. 14606-14617. (doi: 10.1021/acsami.7b00078) (PMID:28157291)

Hernandez-Fernaud, J. R. et al. (2017) Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nature Communications, 8, 14206. (doi: 10.1038/ncomms14206) (PMID:28198360) (PMCID:PMC5316871)

Song, Y. et al. (2017) Single-cell genomics based on Raman sorting reveals novel carotenoid-containing bacteria in the Red Sea. Microbial Biotechnology, 10(1), pp. 125-137. (doi: 10.1111/1751-7915.12420) (PMID:27748032) (PMCID:PMC5270752)

2016

Song, Y., Yin, H. and Huang, W. E. (2016) Raman activated cell sorting. Current Opinion in Chemical Biology, 33, pp. 1-8. (doi: 10.1016/j.cbpa.2016.04.002) (PMID:27100046)

McIlvanna, D., Huang, W. E., Davison, P., Glidle, A., Cooper, J. and Yin, H. (2016) Continuous cell sorting in a flow based on single cell resonance Raman spectra. Lab on a Chip, 16(8), pp. 1420-1429. (doi: 10.1039/C6LC00251J) (PMID:26974400)

Clarke, C. J. et al. (2016) The initiator methionine tRNA drives secretion of type II collagen from stromal fibroblasts to promote tumor growth and angiogenesis. Current Biology, 26(6), pp. 755-765. (doi: 10.1016/j.cub.2016.01.045) (PMID:26948875) (PMCID:PMC4819511)

Cachat, E., Liu, W., Martin, K. C., Yuan, X. , Yin, H. , Hohenstein, P. and Davies, J. A. (2016) 2- and 3-dimensional synthetic large-scale de novo patterning by mammalian cells through phase separation. Scientific Reports, 6, 20664. (doi: 10.1038/srep20664) (PMID:26857385) (PMCID:PMC4746622)

Keating, C. , Song, Y. , Quince, C., Collins, G., Yin, H. and Sloan, W. (2016) Understanding Syntrophy in Anaerobic Digestion. Brazil Newton Fund Researcher Links Workshop – Water, Sanitation, Energy Nexus, Goania, Brazil, 13-16 Sep 2016.

Li, B., Qiu, Y., Shi, H. and Yin, H. (2016) The importance of lag time extension in determining bacterial resistance to antibiotics. Analyst, 141(10), pp. 3059-3067. (doi: 10.1039/C5AN02649K) (PMID:27077143)

2015

Yuan, X. , Zhou, M., Gough, J., Glidle, A. and Yin, H. (2015) A novel culture system for modulating single cell geometry in 3D. Acta Biomaterialia, 24, pp. 228-240. (doi: 10.1016/j.actbio.2015.06.008) (PMID:26086694)

Cameron, J. M., Gabrielsen, M. , Chim, Y. H., Munro, J., McGhee, E. J., Sumpton, D., Eaton, P., Anderson, K. I., Yin, H. and Olson, M. F. (2015) Polarized cell motility induces hydrogen peroxide to inhibit cofilin via cysteine oxidation. Current Biology, 25(11), pp. 1520-1525. (doi: 10.1016/j.cub.2015.04.020)

Zhou, M., Yuan, X. , Yin, H. and Gough, J. E. (2015) Restoration of chondrocytic phenotype on a two-dimensional micropatterned surface. Biointerphases, 10, 011003. (doi: 10.1116/1.4913565)

Zhang, P., Ren, L., Zhang, X., Shan, Y., Wang, Y., Ji, Y., Yin, H. , Huang, W. E., Xu, J. and Ma, B. (2015) Raman-activated cell sorting based on dielectrophoretic single-cell trap and release. Analytical Chemistry, 87(4), pp. 2282-2289. (doi: 10.1021/ac503974e) (PMID:25607599)

Wang, J., Wu, Z., Hu, K., Chen, X. and Yin, H. (2015) High conductivity graphene-like MoS2/polyaniline nanocomposites and its application in supercapacitor. Journal of Alloys and Compounds, 619, pp. 38-43. (doi: 10.1016/j.jallcom.2014.09.008)

Hu, Z., Glidle, A., Ironside, C., Cooper, J. M. and Yin, H. (2015) An integrated microspectrometer for localised multiplexing measurements. Lab on a Chip, 15(1), pp. 283-289. (doi: 10.1039/C4LC00952E)

Song, Y. , Li, B., Qiu, Y. and Yin, H. (2015) Single bacteria studies using microfluidics. In: Hydrocarbon and Lipid Microbiology Protocols. Series: Springer Protocols Handbooks. Springer. (doi: 10.1007/8623_2015_70)

Wang, J., Guo, C., Yu, Y., Yin, H. , Liu, X. and Jiang, Y. (2015) Self-doped 3-hexylthiophene-b-sodium styrene sulfonate block copolymer: synthesis and its organization with CdSe quantum dots. RSC Advances, 5(23), pp. 17905-17914. (doi: 10.1039/c4ra15195j)

2014

Li, B., Qiu, Y., Glidle, A., Cooper, J. , Shi, H. and Yin, H. (2014) Single cell growth rate and morphological dynamics revealing an "opportunistic" persistence. Analyst, 139(13), pp. 3305-3313. (doi: 10.1039/C4AN00170B)

Li, B., Qiu, Y., Glidle, A., McIlvenna, D., Luo, Q., Cooper, J. , Shi, H.-C. and Yin, H. (2014) Gradient microfluidics enables rapid bacterial growth inhibition testing. Analytical Chemistry, 86(6), pp. 3131-3137. (doi: 10.1021/ac5001306)

Wang, J., Wu, Z., Yin, H. , Li, W. and Jiang, Y. (2014) Poly(3,4-ethylenedioxythiophene)/MoS2nanocomposites with enhanced electrochemical capacitance performance. RSC Advances, 4(100), pp. 56926-56932. (doi: 10.1039/C4RA12683A)

Yuan, X. , Chim, Y. and Yin, H. (2014) Linking cell shape, elasticity and fate: in vitro re-differentiation of chondrocytes. In: Optical Elastography and Tissue Biomechanics, San Francisco, CA, USA, 1-2 Feb 2014, 89460M. (doi: 10.1117/12.2039859)

Zhao, C., Lin, Z., Yin, H. , Ma, Y., Xu, F. and Yang, W. (2014) PEG molecular net-cloth grafted on polymeric substrates and its bio-merits. Scientific Reports, 4, 4982. (doi: 10.1038/srep04982) (PMID:24845078) (PMCID:PMC4028697)

2013

Li, C., Glidle, A., Yuan, X. , Hu, Z., Pulleine, E., Cooper, J. , Yang, W. and Yin, H. (2013) Creating “living” polymer surfaces to pattern biomolecules and cells on common plastics. Biomacromolecules, 14(5), pp. 1278-1286. (doi: 10.1021/bm4000597) (PMID:23495918)

Milton, J. A., Patole, S., Yin, H. , Xiao, Q., Brown, T. and Melvin, T. (2013) Efficient self-assembly of DNA-functionalized fluorophores and gold nanoparticles with DNA functionalized silicon surfaces: the effect of oligomer spacers. Nucleic Acids Research, 41(7), e80. (doi: 10.1093/nar/gkt031) (PMID:23361467) (PMCID:PMC3627567)

2012

Qiu, N. et al. (2012) Calcium carbonate microspheres as carriers for the anticancer drug camptothecin. Materials Science and Engineering C: Biomimetic and Supramolecular Systems, 32(8), pp. 2634-2640. (doi: 10.1016/j.msec.2012.08.026)

Hu, Z., Glidle, A., Ironside, C. N., Sorel, M. , Strain, M. J., Cooper, J. and Yin, H. (2012) Integrated microspectrometer for fluorescence based analysis in a microfluidic format. Lab on a Chip, 12(16), pp. 2850-2857. (doi: 10.1039/C2LC40169J)

Zarowna-Dabrowska, A. et al. (2012) Generation of primary hepatocyte microarrays by piezoelectric printing. Colloids and Surfaces B: Biointerfaces, 89, pp. 126-132. (doi: 10.1016/j.colsurfb.2011.09.016)

Cuestas-Ayllon, C., Xiao, Q., Glidle, A., Riehle, M.O. , Cooper, J.M. , de la Fuente, J.M. and Yin, H.B. (2012) A robust lithographic method for multiplex surface pattering. Current Analytical Chemistry, 9(1), pp. 29-36. (doi: 10.2174/1573411011309010029)

Yin, H. and Marshall, D. (2012) Microfluidics for single cell analysis. Current Opinion in Biotechnology, 23(1), pp. 110-119. (doi: 10.1016/j.copbio.2011.11.002)

2011

Kirchhof, K., Andar, A., Yin, H.B. , Gadegaard, N. , Riehle, M.O. and Groth, T. (2011) Polyelectrolyte multilayers generated in a microfluidic device with pH gradients direct adhesion and movement of cells. Lab on a Chip, 11(19), pp. 3326-3335. (doi: 10.1039/C1LC20408D)

Hu, Z., Glidle, A., Ironside, C.N., Sorel, M. , Strain, M.J. and Yin, H. (2011) On-chip micro-spectrometer for fluorescence bio-sensing. In: CLEO Europe 2011, Munich, Germany, 22-26 May 2011, (doi: 10.1109/CLEOE.2011.5943698)

Zarowna-Dabrowska, A. et al. (2011) Miniaturized optoelectronic tweezers controlled by GaN micro-pixel light emitting diode arrays. Optics Express, 19(3), pp. 2720-2728. (doi: 10.1364/OE.19.002720)

2010

Qiu, N., Cai, L.-l., Xie, D., Wang, G., Wu, W., Zhang, Y., Song, H., Yin, H. and Chen, L. (2010) Synthesis, structural andin vitrostudies of well-dispersed monomethoxy-poly(ethylene glycol)–honokiol conjugate micelles. Biomedical Materials, 5(6), 065006. (doi: 10.1088/1748-6041/5/6/065006) (PMID:20966535)

Anderson, K.J., Cooper, J.M. , Haswell, S.J., Marshall, D., Yin, H. and Zhang, X.L. (2010) Microfluidic-based measurements of cytochrome P450 enzyme activity of primary mammalian hepatocytee. Analyst, 135(6), pp. 1282-1287. (doi: 10.1039/c0an00031k)

Ji, B., Cusack, M. , Freer, A., Dobson, P.S. , Gadegaard, N. and Yin, H. (2010) Control of crystal polymorph in microfluidics using molluscan 28 kDa Ca2+-binding protein. Integrative Biology, 2, pp. 528-535. (doi: 10.1039/c0ib00007h) (PMID:20820629)

McPhee, G., Dalby, M.J. , Riehle, M.O. and Yin, H. (2010) Can common adhesion molecules and microtopography affect cellular elasticity? A combined atomic force microscopy and optical study. Medical and Biological Engineering and Computing, 48(10), (doi: 10.1007/s11517-010-0657-3)

Zarowna-Dabrowska, A. et al. (2010) Micromanipulation of beads and CHO cells using micro light emitting diode arrays to control a miniaturised optoelectronic tweezers device. In: IOP Photon10, Southampton, UK, 23-26 Aug 2010,

Zarowna-Dabrowska, A. et al. (2010) Miniaturised optoelectronic tweezers controlled by GaN micro light emitting diode arrays. In: 23rd Annual Meeting of the IEEE Photonics Society, Denver, CO, 7-11 Nov 2010,

2009

Ritchie, C., Cooper, G.J.T. , Song, Y.F., Streb, C., Yin, H.B. , Parenty, A.D.C., MacLaren, D.A. and Cronin, L. (2009) Spontaneous assembly and real-time growth of micrometre-scale tubular structures from polyoxometalate-based inorganic solids. Nature Chemistry, 1(1), pp. 47-52. (doi: 10.1038/nchem.113)

Yin, H. , Bozhi, J., Dobson, P.S. , Mosbahi, K., Glidle, A., Gadegaard, N. , Freer, A., Cooper, J.M. and Cusack, M. (2009) Screening of biomineralization using microfluidics. Analytical Chemistry, 81(1), pp. 473-478. (doi: 10.1021/ac801980b) (PMID:19117468)

Yin, H. , McPhee, G. and Dobson, P. (2009) AFM and development of (bio) fouling-resistant membranes. In: Bowen, W.R. and Hilal, N. (eds.) Atomic Force Microscopy in Process Engineering: Introduction to AFM for Improved Processes and Products. Butterworth-Heinemann: Oxford, UK. ISBN 9781856175173

Yin, H. , McPhee, G. and Dobson, P. (2009) Micro/nanoengineering and AFM for cellular sensing. In: Bowen, W.R. and Hilal, N. (eds.) Atomic Force Microscopy in Process Engineering: Introduction to AFM for Improved Processes and Products. Butterworth-Heinemann: Oxford, UK. ISBN 9781856175173

2008

Cusack, M. , Dauphin, Y., Cuif, J.P., Salomé, M., Freer, A. and Yin, H. (2008) Micro-XANES mapping of sulphur and its association with magnesium and phosphorus in the shell of the brachiopod, Terebratulina retusa. Chemical Geology, 253(3-4), pp. 172-179. (doi: 10.1016/j.chemgeo.2008.05.007)

Zhang, X.L., Yin, H.B. , Cooper, J.M. and Haswell, S.J. (2008) Characterization of cellular chemical dynamics using combined microfluidic and Raman techniques. Analytical and Bioanalytical Chemistry, 390(3), pp. 833-840. (doi: 10.1007/s00216-007-1564-9)

Yin, H. , Pattrick, N., Zhang, X.L., Klauke, N., Cordingley, H.C., Haswell, S.J. and Cooper, J.M. (2008) Quantitative comparison between microfluidic and microtiter plate formats for cell-based assays. Analytical Chemistry, 80(1), pp. 179-185. (doi: 10.1021/ac701958z)

Mushfique, H., Leach, J., Yin, H. , Di Leonardo, R., Padgett, M.J. and Cooper, J.M. (2008) 3D mapping of microfluidic flow in laboratory-on-a-chip structures using optical tweezers. Analytical Chemistry, 80(11), pp. 4237-4240. (doi: 10.1021/ac8002006)

2007

Yin, H. , Zhang, X.L., Pattrick, N., Klauke, N., Cordingley, H.C., Haswell, S.J. and Cooper, J.M. (2007) Influence of hydrodynamic conditions on quantitative cellular assays in microfluidic systems. Analytical Chemistry, 79(18), pp. 7139-7144. (doi: 10.1021/ac071146k)

2006

Melvin, T. et al. (2006) DNA, Nanoparticles and Photons - New Approaches for Clinical Diagnostics. In: 2006 International Symposium on Biophotonics, Nanophotonics and Metamaterials, Hangzhou, China, 16-18 Oct 2006, pp. 20-21. ISBN 9780780397743 (doi: 10.1109/METAMAT.2006.334986)

Zhang, X.L., Yin, H. , Cooper, J.M. and Haswell, S.J. (2006) A microfluidic-based system for analysis of single cells based on Ca²⁺ flux. Electrophoresis, 27(24), pp. 5093-5100. (doi: 10.1002/elps.200600390)

2005

Dyadyusha, L., Yin, H. , Jaiswal, S., Brown, T., Baumberg, J.J., Booy, F.P. and Melvin, T. (2005) Quenching of CdSe quantum dot emission, a new approach for biosensing. Chemical Communications(25), pp. 3201-3203. (doi: 10.1039/B500664c) (PMID:15968371)

2004

Yin, H. B. , Brown, T., Greef, R., Mailis, S., Eason, R., Wilkinson, J. S. and Melvin, T. (2004) Photopatterning of DNA oligonucleotides on silicon surfaces with micron-scale dimensions. In: Biophotonics New Frontier: From Genome to Proteome, Strasbourg, France, 26 Apr 2004, ISBN 9780819453846 (doi: 10.1117/12.545736)

Yin, H.B. , Brown, T., Greef, R., Wilkinson, J.S. and Melvin, T. (2004) Chemical modification and micropatterning of Si(1 0 0) with oligonucleotides. Microelectronic Engineering, 73-74, pp. 830-836. (doi: 10.1016/j.mee.2004.03.060)

Doneva, T.A., Yin, H.B. , Stephens, P., Bowen, W.R. and Thomas, D.W. (2004) Development and AFM study of porous scaffolds for wound healing applications. Spectroscopy, 18(4), pp. 587-596. (doi: 10.1155/2004/251698)

Yin, H.B. , Brown, T., Wilkinson, J.S., Eason, R.W. and Melvin, T. (2004) Submicron patterning of DNA oligonucleotides on silicon. Nucleic Acids Research, 32(14), e118. (doi: 10.1093/nar/gnh113) (PMID:15314186) (PMCID:PMC514397)

2002

Bowen, W. R., Doneva, T. A. and Yin, H.B. (2002) Atomic force microscopy studies of membrane—solute interactions (fouling). Desalination, 146(1-3), pp. 97-102. (doi: 10.1016/S0011-9164(02)00496-4)

Bowen, W. R., Doneva, T. A. and Yin, H. (2002) The effect of sulfonated poly(ether ether ketone) additives on membrane formation and performance. Desalination, 145(1-3), pp. 39-45. (doi: 10.1016/S0011-9164(02)00364-8)

Bowen, W. R., Doneva, T. A. and Yin, H.-B. (2002) Separation of humic acid from a model surface water with PSU/SPEEK blend UF/NF membranes. Journal of Membrane Science, 206(1-2), pp. 417-429. (doi: 10.1016/S0376-7388(01)00786-4)

2001

Bowen, W. R., Doneva, T. A. and Yin, H.B. (2001) Polysulfone — sulfonated poly(ether ether) ketone blend membranes: systematic synthesis and characterisation. Journal of Membrane Science, 181(2), pp. 253-263. (doi: 10.1016/S0376-7388(00)00541-X)

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