Dr Stuart Caldwell
- Research Associate (School of Chemistry)
telephone:
01413306554
email:
Stuart.Caldwell@glasgow.ac.uk
Chemistry, Joseph Black Building, Glasgow G12 8QQ
https://orcid.org/0000-0003-1604-3462Research interests
Research groups
Publications
2025
Eaglesfield, R., Fernandez-Vizarra, E., Lacko, E., Caldwell, S. T. , Sloan, N. L., Siciarz, D., Hartley, R. C. and Tokatlidis, K. (2025) Sub-organellar mitochondrial hydrogen peroxide observed using a SNAP tag targeted coumarin-based fluorescent reporter. Redox Biology, 80, 103502. (doi: 10.1016/j.redox.2025.103502) (PMID:39864323) (PMCID:PMC11802384)
2023
Uno, S., Harkiss, A. H., Chowdhury, R., Caldwell, S. T. , Prime, T. A., James, A. M., Gallagher, B., Prudent, J., Hartley, R. C. and Murphy, M. P. (2023) Incorporating a polyethyleneglycol linker to enhance the hydrophilicity of mitochondria‐targeted triphenylphosphonium constructs. ChemBioChem, 24(11), e202200774. (doi: 10.1002/cbic.202200774) (PMID:36917207) (PMCID:PMC10946768)
2022
Miljkovic, J. L. et al. (2022) Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury. Redox Biology, 55, 102429. (doi: 10.1016/j.redox.2022.102429) (PMID:35961099) (PMCID:PMC9382561)
Prag, H. A. et al. (2022) Ester prodrugs of malonate with enhanced intracellular delivery protect against cardiac ischemia-reperfusion injury in vivo. Cardiovascular Drugs and Therapy, 36(1), pp. 1-13. (doi: 10.1007/s10557-020-07033-6) (PMID:32648168) (PMCID:PMC8770414)
2021
Caldwell, S. T. , O'Byrne, S., Wilson, C., Cvetko, F., Murphy, M. P., McCarron, J. G. and Hartley, R. C. (2021) Photoactivated release of membrane impermeant sulfonates inside cells. Chemical Communications, 57(32), pp. 3917-3920. (doi: 10.1039/D0CC07713E) (PMID:33871501) (PMCID:PMC7611313)
Gaddale Devanna, K. K. et al. (2021) Tetra-arylborate lipophilic anions as targeting groups. Chemical Communications, 57(25), pp. 3147-3150. (doi: 10.1039/D0CC07924C) (PMID:33634803) (PMCID:PMC8062962)
Cvetko, F., Caldwell, S. T. , Higgins, M., Suzuki, T., Yamamoto, M., Prag, H. A., Hartley, R. C. , Dinkova-Kostova, A. and Murphy, M. P. (2021) Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production. Journal of Biological Chemistry, 296, 100169. (doi: 10.1074/jbc.RA120.016551) (PMID:33298526) (PMCID:PMC7948991)
Tan, S. M. et al. (2021) Targeting methylglyoxal in diabetic kidney disease using the mitochondria-targeted compound MitoGamide. Nutrients, 13(5), 1457. (doi: 10.3390/nu13051457) (PMID:33922959) (PMCID:PMC8145135)
2020
Park, M. et al. (2020) Confirmation of the cardioprotective effect of MitoGamide in the diabetic heart. Cardiovascular Drugs and Therapy, 34, pp. 823-834. (doi: 10.1007/s10557-020-07086-7) (PMID:32979176)
Pala, L., Senn, H. M. , Caldwell, S. T. , Prime, T. A., Warrington, S., Bright, T. P., Prag, H. A., Wilson, C. , Murphy, M. and Hartley, R. C. (2020) Enhancing the mitochondrial uptake of phosphonium cations by carboxylic acid incorporation. Frontiers in Chemistry, 8, 783. (doi: 10.3389/fchem.2020.00783)
Prag, H. A., Kula-Alwar, D., Pala, L., Caldwell, S. T. , Beach, T. E., James, A. M., Saeb-Parsy, K., Krieg, T., Hartley, R. C. and Murphy, M. P. (2020) Selective delivery of dicarboxylates to mitochondria by conjugation to a lipophilic cation via a cleavable linker. Molecular Pharmaceutics, 17(9), pp. 3526-3540. (doi: 10.1021/acs.molpharmaceut.0c00533) (PMID:32692564) (PMCID:PMC7482397)
Burger, N., Logan, A., Prime, T. A., Mottahedin, A., Caldwell, S. T. , Krieg, T., Hartley, R. C. , James, A. M. and Murphy, M. P. (2020) A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo. Free Radical Biology and Medicine, 147, pp. 37-47. (doi: 10.1016/j.freeradbiomed.2019.11.028) (PMID:31811922) (PMCID:PMC6975167)
2019
Tate, M. et al. (2019) The mitochondria-targeted methylglyoxal sequestering compound, MitoGamide, is cardioprotective in the diabetic heart. Cardiovascular Drugs and Therapy, 33(6), pp. 669-674. (doi: 10.1007/s10557-019-06914-9) (PMID:31654171) (PMCID:PMC6994445)
Martin, J. et al. (2019) Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation. Nature Metabolism, 1(10), pp. 966-974. (doi: 10.1038/s42255-019-0115-y)
Antonucci, S. et al. (2019) Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis. Free Radical Biology and Medicine, 134, pp. 678-687. (doi: 10.1016/j.freeradbiomed.2019.01.034) (PMID:30731114)
Booty, L. M. et al. (2019) Selective disruption of mitochondrial thiol redox state in cells and in vivo. Cell Chemical Biology, 26(3), 449-461.e8. (doi: 10.1016/j.chembiol.2018.12.002) (PMID:30713096) (PMCID:PMC6436940)
2018
Fazakerley, D. J. et al. (2018) Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation. Journal of Biological Chemistry, 293(19), pp. 7315-7328. (doi: 10.1074/jbc.RA117.001254) (PMID:29599292) (PMCID:PMC5950018)
Mills, E. L. et al. (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 5556, pp. 113-117. (doi: 10.1038/nature25986) (PMID:29590092) (PMCID:PMC6047741)
Cao, Z., Mitchell, L., Hsia, O., Scarpa, M., Caldwell, S. T. , Alfred, A. D., Gennaris, A., Collet, J.-F., Hartley, R. C. and Bulleid, N. J. (2018) Methionine sulfoxide reductase B3 requires resolving cysteine residues for full activity and can act as a stereospecific methionine oxidase. Biochemical Journal, 475, pp. 827-838. (doi: 10.1042/BCJ20170929) (PMID:29420254) (PMCID:PMC6488974)
2017
Shchepinova, M. M. et al. (2017) MitoNeoD: a mitochondria-targeted superoxide probe. Cell Chemical Biology, 24(10), 1285-1298.e12. (doi: 10.1016/j.chembiol.2017.08.003) (PMID:28890317) (PMCID:PMC6278870)
2015
Caldwell, S. T. , Cairns, A. G., Olson, M., Chalmers, S., Sandison, M., Mullen, W. , McCarron, J. G. and Hartley, R. C. (2015) Synthesis of an azido-tagged low affinity ratiometric calcium sensor. Tetrahedron, 71(51), pp. 9571-9578. (doi: 10.1016/j.tet.2015.10.052) (PMID:26709317) (PMCID:PMC4660056)
2014
Caldwell, S.T. et al. (2014) Protein-mediated dethreading of a biotin-functionalised pseudorotaxane. Organic and Biomolecular Chemistry, 12(3), pp. 511-516. (doi: 10.1039/C3OB41612G) (PMID:24280954)
2013
Anamimoghadam, O., Symes, M. D. , Busche, C. , Long, D.-L. , Caldwell, S. T. , Flors, C., Nonell, S., Cronin, L. and Bucher, G. (2013) Naphthoxanthenyl, a new stable phenalenyl type radical stabilized by electronic effects. Organic Letters, 15(12), pp. 2970-2973. (doi: 10.1021/ol401117g)
McQuaker, S. J., Quinlan, C. L., Caldwell, S. T. , Brand, M. D. and Hartley, R. C. (2013) A prototypical small-molecule modulator uncouples mitochondria in response to endogenous hydrogen peroxide production. ChemBioChem, 14(8), pp. 993-1000. (doi: 10.1002/cbic.201300115) (PMID:23640856) (PMCID:PMC3743171)
Pauszek, R. F., Kodali, G., Caldwell, S. T. , Fitzpatrick, B., Zainalabdeen, N. Y., Cooke, G. , Rotello, V. M. and Stanley, R. J. (2013) Excited state charge redistribution and dynamics in the donor-π-acceptor flavin derivative ABFL. Journal of Physical Chemistry B, 117(49), pp. 15684-15694. (doi: 10.1021/jp406420h)
2012
Caldwell, S.T. , McPhail, D.B., Duthie, G.D. and Hartley, R.C. (2012) Synthesis of polyhydroxylated flavonoids bearing a lipophilic decyl tail as potential therapeutic antioxidants. Canadian Journal of Chemistry = Journal canadien de chimie, 90(1), pp. 23-33. (doi: 10.1139/V11-087)
Chalmers, S., Caldwell, S. T. , Quin, C., Prime, T. A., James, A. M., Cairns, A. G., Murphy, M. P., McCarron, J. G. and Hartley, R. C. (2012) Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore. Journal of the American Chemical Society, 134(2), pp. 758-761. (doi: 10.1021/ja2077922) (PMID:22239373) (PMCID:PMC3260739)
Omar, M.H., Mullen, W. , Stalmach, A. , Auger, C., Rouanet, J.-M., Teissedre, P.-L., Caldwell, S.T. , Hartley, R.C. and Crozier, A. (2012) Absorption, disposition, metabolism, and excretion of [3-14C]caffeic acid in rats. Journal of Agricultural and Food Chemistry, 60(20), pp. 5205-5214. (doi: 10.1021/jf3001185)
2011
McDonald, N.A., Subramani, C., Caldwell, S.T. , Zainalabdeen, N.Y., Cooke, G. and Rotello, V.M. (2011) Simultaneous hydrogen bonding and π-stacking interactions between flavin/porphyrin host–guest syst. Tetrahedron Letters, 52(17), pp. 2107-2110. (doi: 10.1016/j.tetlet.2010.11.004)
2010
Figlus, M., Caldwell, S.T. , Walas, D., Yesilbag, G., Cooke, G. , Kocovsky, P., Malkov, A.V. and Sanyal, A. (2010) Dendron-anchored organocatalysts: the asymmetric reduction of imines with trichlorosilane, catalysed by an amino acid-derived formamide appended to a dendron. Organic and Biomolecular Chemistry, 8(1), pp. 137-141. (doi: 10.1039/b916601g)
Siddle, J. S., Batsanov, A. S., Caldwell, S. T. , Cooke, G. and Bryce, M. R. (2010) Divergent synthesis of arylated pyridin-2(1H)-one derivatives via metal-catalysed cross-coupling processes. Tetrahedron, 66(32), pp. 6138-6149. (doi: 10.1016/j.tet.2010.05.108)
Spreull, J.M. et al. (2010) Highly stable tetrathiafulvalene radical dimers in [3]catenanes. Nature Chemistry, 2(10), pp. 870-879. (doi: 10.1038/nchem.749)
2009
Bigot, J. et al. (2009) LCST: a powerful tool to control complexation between a dialkoxynaphthalene-functionalised poly(N-isopropylacrylamide) and CBPQT(4+) in water. Chemical Communications(35), pp. 5266-5268. (doi: 10.1039/b910856d)
Caldwell, S. T. , Farrugia, L. J., Hewage, S. G., Kryvokhyzha, N., Rotello, V. M. and Cooke, G. (2009) Model systems for flavoenzyme activity: an investigation of the role functionality attached to the C(7) position of the flavin unit has on redox and molecular recognition properties. Chemical Communications(11), pp. 1350-1352. (doi: 10.1039/b900269n)
Malkov, A. V., Figlus, M., Cooke, G. , Caldwell, S.T. , Rabani, G., Prestly, M. R. and Kocovsky, P. (2009) Organocatalysts immobilised onto gold nanoparticles: application in the asymmetric reduction of imines with trichlorosilane. Organic and Biomolecular Chemistry, 7(9), pp. 1878-1883. (doi: 10.1039/b821391g)
Patra, D., Pagliuca, C., Subramani, C., Samanta, B., Agasti, S. S., Zainalabdeen, N., Caldwell, S. T. , Cooke, G. and Rotello, V. M. (2009) Molecular recognition at the liquid-liquid interface of colloidal microcapsules. Chemical Communications(28), pp. 4248-4250. (doi: 10.1039/b906458c)
2008
Jordan, B.J. et al. (2008) 'Lock and key' control of optical properties in a push-pull system. Chemical Communications(14), pp. 1653-1655. (doi: 10.1039/b718015b)
Agasti, S. S., Caldwell, S. T. , Cooke, G. , Jordan, B. J., Kennedy, A., Kryvokhyzha, N., Rabani, G., Rana, S., Sanyal, A. and Rotello, V. M. (2008) Dendron-based model systems for flavoenzyme activity: towards a new class of synthetic flavoenzyme. Chemical Communications(35), pp. 4123-4125. (doi: 10.1039/b809568j)
Caldwell, S. T. , Cooke, G. , Cooper, A., Nutley, M., Rabani, G., Rotello, V., Smith, B. O. and Woisel, P. (2008) Tuneable pseudorotaxane formation between a biotin-avidin bioconjugate and CBPQT(4+). Chemical Communications(23), pp. 2650-2652. (doi: 10.1039/b803856b)
Caldwell, S. T. , Cooke, G. , Fitzpatrick, B., Long, D.L. , Rabani, G. and Rotello, V. M. (2008) A flavin-based [2]catenane. Chemical Communications(45), pp. 5912-5914. (doi: 10.1039/b813779j)
Caldwell, S. T. , Cooke, G. , Hewage, S. G., Mabruk, S., Rabani, G., Rotello, V., Smith, B.O. , Subramani, C. and Woisel, P. (2008) Model systems for flavoenzyme activity: intramolecular self-assembly of a flavin derivative via hydrogen bonding and aromatic interactions. Chemical Communications(35), pp. 4126-4128. (doi: 10.1039/b809762c)
Jordan, B. J., Ofir, Y., Patra, D., Caldwell, S. T. , Kennedy, A., Joubanian, S., Rabani, G., Cooke, G. and Rotello, V. M. (2008) Controlled Self-Assembly of Organic Nanowires and Platelets Using Dipolar and Hydrogen-Bonding Interactions. Small, 4(11), pp. 2074-2078. (doi: 10.1002/smll.200800811)
Mullen, W. , Rouanet, J.-M., Auger, C., Teissèdre, P.-L., Caldwell, S.T. , Hartley, R.C. , Lean, M.E.J. , Edwards, C.A. and Crozier, A. (2008) Bioavailability of [2-14C]Quercetin-4′-glucoside in rats. Journal of Agricultural and Food Chemistry, 56(24), pp. 12127-12137. (doi: 10.1021/jf802754s)
2000
Caldwell, S. T. , Crozier, A. and Hartley, R. C. (2000) Isotopic labelling of quercetin 4 '-O-beta-D-glucoside. Tetrahedron, 56(24), pp. 4101-4106. (doi: 10.1016/s0040-4020(00)00325-2)
Hartley, R. C. and Caldwell, S. T. (2000) Novel methods for the synthesis of three-, four-, five-, six- and seven-membered, saturated and partially unsaturated carbocycles. Journal of the Chemical Society: Perkin Transactions 1, 1(4), pp. 477-501. (doi: 10.1039/A804421J)
Articles
Eaglesfield, R., Fernandez-Vizarra, E., Lacko, E., Caldwell, S. T. , Sloan, N. L., Siciarz, D., Hartley, R. C. and Tokatlidis, K. (2025) Sub-organellar mitochondrial hydrogen peroxide observed using a SNAP tag targeted coumarin-based fluorescent reporter. Redox Biology, 80, 103502. (doi: 10.1016/j.redox.2025.103502) (PMID:39864323) (PMCID:PMC11802384)
Uno, S., Harkiss, A. H., Chowdhury, R., Caldwell, S. T. , Prime, T. A., James, A. M., Gallagher, B., Prudent, J., Hartley, R. C. and Murphy, M. P. (2023) Incorporating a polyethyleneglycol linker to enhance the hydrophilicity of mitochondria‐targeted triphenylphosphonium constructs. ChemBioChem, 24(11), e202200774. (doi: 10.1002/cbic.202200774) (PMID:36917207) (PMCID:PMC10946768)
Miljkovic, J. L. et al. (2022) Rapid and selective generation of H2S within mitochondria protects against cardiac ischemia-reperfusion injury. Redox Biology, 55, 102429. (doi: 10.1016/j.redox.2022.102429) (PMID:35961099) (PMCID:PMC9382561)
Prag, H. A. et al. (2022) Ester prodrugs of malonate with enhanced intracellular delivery protect against cardiac ischemia-reperfusion injury in vivo. Cardiovascular Drugs and Therapy, 36(1), pp. 1-13. (doi: 10.1007/s10557-020-07033-6) (PMID:32648168) (PMCID:PMC8770414)
Caldwell, S. T. , O'Byrne, S., Wilson, C., Cvetko, F., Murphy, M. P., McCarron, J. G. and Hartley, R. C. (2021) Photoactivated release of membrane impermeant sulfonates inside cells. Chemical Communications, 57(32), pp. 3917-3920. (doi: 10.1039/D0CC07713E) (PMID:33871501) (PMCID:PMC7611313)
Gaddale Devanna, K. K. et al. (2021) Tetra-arylborate lipophilic anions as targeting groups. Chemical Communications, 57(25), pp. 3147-3150. (doi: 10.1039/D0CC07924C) (PMID:33634803) (PMCID:PMC8062962)
Cvetko, F., Caldwell, S. T. , Higgins, M., Suzuki, T., Yamamoto, M., Prag, H. A., Hartley, R. C. , Dinkova-Kostova, A. and Murphy, M. P. (2021) Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production. Journal of Biological Chemistry, 296, 100169. (doi: 10.1074/jbc.RA120.016551) (PMID:33298526) (PMCID:PMC7948991)
Tan, S. M. et al. (2021) Targeting methylglyoxal in diabetic kidney disease using the mitochondria-targeted compound MitoGamide. Nutrients, 13(5), 1457. (doi: 10.3390/nu13051457) (PMID:33922959) (PMCID:PMC8145135)
Park, M. et al. (2020) Confirmation of the cardioprotective effect of MitoGamide in the diabetic heart. Cardiovascular Drugs and Therapy, 34, pp. 823-834. (doi: 10.1007/s10557-020-07086-7) (PMID:32979176)
Pala, L., Senn, H. M. , Caldwell, S. T. , Prime, T. A., Warrington, S., Bright, T. P., Prag, H. A., Wilson, C. , Murphy, M. and Hartley, R. C. (2020) Enhancing the mitochondrial uptake of phosphonium cations by carboxylic acid incorporation. Frontiers in Chemistry, 8, 783. (doi: 10.3389/fchem.2020.00783)
Prag, H. A., Kula-Alwar, D., Pala, L., Caldwell, S. T. , Beach, T. E., James, A. M., Saeb-Parsy, K., Krieg, T., Hartley, R. C. and Murphy, M. P. (2020) Selective delivery of dicarboxylates to mitochondria by conjugation to a lipophilic cation via a cleavable linker. Molecular Pharmaceutics, 17(9), pp. 3526-3540. (doi: 10.1021/acs.molpharmaceut.0c00533) (PMID:32692564) (PMCID:PMC7482397)
Burger, N., Logan, A., Prime, T. A., Mottahedin, A., Caldwell, S. T. , Krieg, T., Hartley, R. C. , James, A. M. and Murphy, M. P. (2020) A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo. Free Radical Biology and Medicine, 147, pp. 37-47. (doi: 10.1016/j.freeradbiomed.2019.11.028) (PMID:31811922) (PMCID:PMC6975167)
Tate, M. et al. (2019) The mitochondria-targeted methylglyoxal sequestering compound, MitoGamide, is cardioprotective in the diabetic heart. Cardiovascular Drugs and Therapy, 33(6), pp. 669-674. (doi: 10.1007/s10557-019-06914-9) (PMID:31654171) (PMCID:PMC6994445)
Martin, J. et al. (2019) Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation. Nature Metabolism, 1(10), pp. 966-974. (doi: 10.1038/s42255-019-0115-y)
Antonucci, S. et al. (2019) Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis. Free Radical Biology and Medicine, 134, pp. 678-687. (doi: 10.1016/j.freeradbiomed.2019.01.034) (PMID:30731114)
Booty, L. M. et al. (2019) Selective disruption of mitochondrial thiol redox state in cells and in vivo. Cell Chemical Biology, 26(3), 449-461.e8. (doi: 10.1016/j.chembiol.2018.12.002) (PMID:30713096) (PMCID:PMC6436940)
Fazakerley, D. J. et al. (2018) Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation. Journal of Biological Chemistry, 293(19), pp. 7315-7328. (doi: 10.1074/jbc.RA117.001254) (PMID:29599292) (PMCID:PMC5950018)
Mills, E. L. et al. (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature, 5556, pp. 113-117. (doi: 10.1038/nature25986) (PMID:29590092) (PMCID:PMC6047741)
Cao, Z., Mitchell, L., Hsia, O., Scarpa, M., Caldwell, S. T. , Alfred, A. D., Gennaris, A., Collet, J.-F., Hartley, R. C. and Bulleid, N. J. (2018) Methionine sulfoxide reductase B3 requires resolving cysteine residues for full activity and can act as a stereospecific methionine oxidase. Biochemical Journal, 475, pp. 827-838. (doi: 10.1042/BCJ20170929) (PMID:29420254) (PMCID:PMC6488974)
Shchepinova, M. M. et al. (2017) MitoNeoD: a mitochondria-targeted superoxide probe. Cell Chemical Biology, 24(10), 1285-1298.e12. (doi: 10.1016/j.chembiol.2017.08.003) (PMID:28890317) (PMCID:PMC6278870)
Caldwell, S. T. , Cairns, A. G., Olson, M., Chalmers, S., Sandison, M., Mullen, W. , McCarron, J. G. and Hartley, R. C. (2015) Synthesis of an azido-tagged low affinity ratiometric calcium sensor. Tetrahedron, 71(51), pp. 9571-9578. (doi: 10.1016/j.tet.2015.10.052) (PMID:26709317) (PMCID:PMC4660056)
Caldwell, S.T. et al. (2014) Protein-mediated dethreading of a biotin-functionalised pseudorotaxane. Organic and Biomolecular Chemistry, 12(3), pp. 511-516. (doi: 10.1039/C3OB41612G) (PMID:24280954)
Anamimoghadam, O., Symes, M. D. , Busche, C. , Long, D.-L. , Caldwell, S. T. , Flors, C., Nonell, S., Cronin, L. and Bucher, G. (2013) Naphthoxanthenyl, a new stable phenalenyl type radical stabilized by electronic effects. Organic Letters, 15(12), pp. 2970-2973. (doi: 10.1021/ol401117g)
McQuaker, S. J., Quinlan, C. L., Caldwell, S. T. , Brand, M. D. and Hartley, R. C. (2013) A prototypical small-molecule modulator uncouples mitochondria in response to endogenous hydrogen peroxide production. ChemBioChem, 14(8), pp. 993-1000. (doi: 10.1002/cbic.201300115) (PMID:23640856) (PMCID:PMC3743171)
Pauszek, R. F., Kodali, G., Caldwell, S. T. , Fitzpatrick, B., Zainalabdeen, N. Y., Cooke, G. , Rotello, V. M. and Stanley, R. J. (2013) Excited state charge redistribution and dynamics in the donor-π-acceptor flavin derivative ABFL. Journal of Physical Chemistry B, 117(49), pp. 15684-15694. (doi: 10.1021/jp406420h)
Caldwell, S.T. , McPhail, D.B., Duthie, G.D. and Hartley, R.C. (2012) Synthesis of polyhydroxylated flavonoids bearing a lipophilic decyl tail as potential therapeutic antioxidants. Canadian Journal of Chemistry = Journal canadien de chimie, 90(1), pp. 23-33. (doi: 10.1139/V11-087)
Chalmers, S., Caldwell, S. T. , Quin, C., Prime, T. A., James, A. M., Cairns, A. G., Murphy, M. P., McCarron, J. G. and Hartley, R. C. (2012) Selective uncoupling of individual mitochondria within a cell using a mitochondria-targeted photoactivated protonophore. Journal of the American Chemical Society, 134(2), pp. 758-761. (doi: 10.1021/ja2077922) (PMID:22239373) (PMCID:PMC3260739)
Omar, M.H., Mullen, W. , Stalmach, A. , Auger, C., Rouanet, J.-M., Teissedre, P.-L., Caldwell, S.T. , Hartley, R.C. and Crozier, A. (2012) Absorption, disposition, metabolism, and excretion of [3-14C]caffeic acid in rats. Journal of Agricultural and Food Chemistry, 60(20), pp. 5205-5214. (doi: 10.1021/jf3001185)
McDonald, N.A., Subramani, C., Caldwell, S.T. , Zainalabdeen, N.Y., Cooke, G. and Rotello, V.M. (2011) Simultaneous hydrogen bonding and π-stacking interactions between flavin/porphyrin host–guest syst. Tetrahedron Letters, 52(17), pp. 2107-2110. (doi: 10.1016/j.tetlet.2010.11.004)
Figlus, M., Caldwell, S.T. , Walas, D., Yesilbag, G., Cooke, G. , Kocovsky, P., Malkov, A.V. and Sanyal, A. (2010) Dendron-anchored organocatalysts: the asymmetric reduction of imines with trichlorosilane, catalysed by an amino acid-derived formamide appended to a dendron. Organic and Biomolecular Chemistry, 8(1), pp. 137-141. (doi: 10.1039/b916601g)
Siddle, J. S., Batsanov, A. S., Caldwell, S. T. , Cooke, G. and Bryce, M. R. (2010) Divergent synthesis of arylated pyridin-2(1H)-one derivatives via metal-catalysed cross-coupling processes. Tetrahedron, 66(32), pp. 6138-6149. (doi: 10.1016/j.tet.2010.05.108)
Spreull, J.M. et al. (2010) Highly stable tetrathiafulvalene radical dimers in [3]catenanes. Nature Chemistry, 2(10), pp. 870-879. (doi: 10.1038/nchem.749)
Bigot, J. et al. (2009) LCST: a powerful tool to control complexation between a dialkoxynaphthalene-functionalised poly(N-isopropylacrylamide) and CBPQT(4+) in water. Chemical Communications(35), pp. 5266-5268. (doi: 10.1039/b910856d)
Caldwell, S. T. , Farrugia, L. J., Hewage, S. G., Kryvokhyzha, N., Rotello, V. M. and Cooke, G. (2009) Model systems for flavoenzyme activity: an investigation of the role functionality attached to the C(7) position of the flavin unit has on redox and molecular recognition properties. Chemical Communications(11), pp. 1350-1352. (doi: 10.1039/b900269n)
Malkov, A. V., Figlus, M., Cooke, G. , Caldwell, S.T. , Rabani, G., Prestly, M. R. and Kocovsky, P. (2009) Organocatalysts immobilised onto gold nanoparticles: application in the asymmetric reduction of imines with trichlorosilane. Organic and Biomolecular Chemistry, 7(9), pp. 1878-1883. (doi: 10.1039/b821391g)
Patra, D., Pagliuca, C., Subramani, C., Samanta, B., Agasti, S. S., Zainalabdeen, N., Caldwell, S. T. , Cooke, G. and Rotello, V. M. (2009) Molecular recognition at the liquid-liquid interface of colloidal microcapsules. Chemical Communications(28), pp. 4248-4250. (doi: 10.1039/b906458c)
Jordan, B.J. et al. (2008) 'Lock and key' control of optical properties in a push-pull system. Chemical Communications(14), pp. 1653-1655. (doi: 10.1039/b718015b)
Agasti, S. S., Caldwell, S. T. , Cooke, G. , Jordan, B. J., Kennedy, A., Kryvokhyzha, N., Rabani, G., Rana, S., Sanyal, A. and Rotello, V. M. (2008) Dendron-based model systems for flavoenzyme activity: towards a new class of synthetic flavoenzyme. Chemical Communications(35), pp. 4123-4125. (doi: 10.1039/b809568j)
Caldwell, S. T. , Cooke, G. , Cooper, A., Nutley, M., Rabani, G., Rotello, V., Smith, B. O. and Woisel, P. (2008) Tuneable pseudorotaxane formation between a biotin-avidin bioconjugate and CBPQT(4+). Chemical Communications(23), pp. 2650-2652. (doi: 10.1039/b803856b)
Caldwell, S. T. , Cooke, G. , Fitzpatrick, B., Long, D.L. , Rabani, G. and Rotello, V. M. (2008) A flavin-based [2]catenane. Chemical Communications(45), pp. 5912-5914. (doi: 10.1039/b813779j)
Caldwell, S. T. , Cooke, G. , Hewage, S. G., Mabruk, S., Rabani, G., Rotello, V., Smith, B.O. , Subramani, C. and Woisel, P. (2008) Model systems for flavoenzyme activity: intramolecular self-assembly of a flavin derivative via hydrogen bonding and aromatic interactions. Chemical Communications(35), pp. 4126-4128. (doi: 10.1039/b809762c)
Jordan, B. J., Ofir, Y., Patra, D., Caldwell, S. T. , Kennedy, A., Joubanian, S., Rabani, G., Cooke, G. and Rotello, V. M. (2008) Controlled Self-Assembly of Organic Nanowires and Platelets Using Dipolar and Hydrogen-Bonding Interactions. Small, 4(11), pp. 2074-2078. (doi: 10.1002/smll.200800811)
Mullen, W. , Rouanet, J.-M., Auger, C., Teissèdre, P.-L., Caldwell, S.T. , Hartley, R.C. , Lean, M.E.J. , Edwards, C.A. and Crozier, A. (2008) Bioavailability of [2-14C]Quercetin-4′-glucoside in rats. Journal of Agricultural and Food Chemistry, 56(24), pp. 12127-12137. (doi: 10.1021/jf802754s)
Caldwell, S. T. , Crozier, A. and Hartley, R. C. (2000) Isotopic labelling of quercetin 4 '-O-beta-D-glucoside. Tetrahedron, 56(24), pp. 4101-4106. (doi: 10.1016/s0040-4020(00)00325-2)
Hartley, R. C. and Caldwell, S. T. (2000) Novel methods for the synthesis of three-, four-, five-, six- and seven-membered, saturated and partially unsaturated carbocycles. Journal of the Chemical Society: Perkin Transactions 1, 1(4), pp. 477-501. (doi: 10.1039/A804421J)
Research datasets
2025
Caldwell, S. T. , Sloan, N. L. and Hartley, R. C. (2025) Sub-organellar mitochondrial hydrogen peroxide observed using a SNAP tag targeted coumarin-based fluorescent reporter. [Data Collection]
2023
Uno, S., Harkiss, A., Chowdhury, R., Caldwell, S. , Prime, T. A., James, A. M., Gallagher, B., Prudent, J., Hartley, R. and Murphy, M. (2023) Incorporating a Polyethyleneglycol Linker to Enhance the Hydrophilicity of Mitochondria-Targeted Triphenylphosphonium Constructs. [Data Collection]
2022
Miljkovic, J. L., Burger, N., Gawel, J. M., Mulvey, J. F., Norman, A. A. I., Nishimura, T., Tsujihata, Y., Logan, A., Sauchanka, O., Caldwell, S. , Morris, J. L., Prudent, J., Prime, T. A., Warrington, S., Bates, G. R., Aksentijević, D., Prag, H., James, A. M., Krieg, T., Hartley, R. and Murphy, M. (2022) Rapid and Selective Generation of H2S within Mitochondria Protects Against Cardiac Ischemia-Reperfusion Injury. [Data Collection]
2020
Pala, L., Senn, H. , Caldwell, S. , Prime, T. A., Warrington, S., Bright, T. P., Prag, H., Wilson, C. , Murphy, M. and Hartley, R. (2020) Enhancing the Mitochondrial Uptake of Phosphonium Cations by Carboxylic Acid Incorporation. [Data Collection]
Prag, H. A., Kula-Alwar, D., Pala, L., Caldwell, S. , Beach, T., James, A. M., Saeb-Parsy, K., Krieg, T., Hartley, R. and Murphy, M. (2020) Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker. [Data Collection]
2019
Burger, N., Logan, A., Prime, T. A., Mottahedin, A., Caldwell, S. , Krieg, T., Hartley, R. , James, A. M. and Murphy, M. P. (2019) A sensitive mass spectrometric assay for mitochondrial CoQ pool redox state in vivo. [Data Collection]
Antonucci, S., Mulvey, J. F., Burger, N., Di Sante, M., Hall, A. R., Hinchy, E. C., Caldwell, S. , Gruszczyk, A. V., Deshwal, S., Hartley, R. , Kaludercic, N., Murphy, M. P., Di Lisa, F. and Kreig, T. (2019) Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis. [Data Collection]
2018
Tate, M., De Blasio, M. J., Prakoso, D., Deo, M., Higgins, G. C., Lindblom, R., Kiriazis, H., Baeza-Garza, C. D., Caldwell, S., Hartley, R. , Krieg, T., Murphy, M. P., Coughlan, M. T. and Ritchie, R. H. (2018) The mitochondria-targeted methylglyoxal sequestering compound, MitoGamide is cardioprotective in the diabetic heart. [Data Collection] (Unpublished)
Martin, J. L., Costa, A. S. H., Gruszczyk, A., Beach, T., Allen, F., Prag, H., Hinchy, E. C., Mahbubani, K., Hamed, M., Tronci, L., Nikitopoulou, E., James, A. M., Krieg, T., Robinson, A., Huang, M. H., Caldwell, S. , Logan, A., Pala, L., Hartley, R. , Frezza, C., Saeb-Parsy, K. and Murphy, M. (2018) Succinate accumulation during organ storage drives ischemia-reperfusion injury upon transplantation. [Data Collection]
