2024

Timmers, M., Kong, M., Schuckman, P., Meulemans, T., Rijcken, C., Hennink, W., Vermonden, T. and Liskamp, R. M. J. (2024) Silicon‐based linkers for tunable acid‐sensitive drug release from polymeric nanoparticles. Chemistry: A European Journal, (doi: 10.1002/chem.202403589) (Early Online Publication)

2023

Hebels, E. R., Dietl, S., Timmers, M., Hak, J., van den Dikkenberg, A., Rijcken, C. J.F., Hennink, W. E., Liskamp, R.J. and Vermonden, T. (2023) Versatile click linker enabling native peptide release from nanocarriers upon redox trigger. Bioconjugate Chemistry, 34(12), pp. 2375-2386. (doi: 10.1021/acs.bioconjchem.3c00484) (PMID:38079189) (PMCID:PMC10739580)

Timmers, M. et al. (2023) Exploring the chemical properties and medicinal applications of tetramethylthiocycloheptyne sulfoximine used in strain-promoted azide–alkyne cycloaddition reactions. Pharmaceuticals, 16(8), 1155. (doi: 10.3390/ph16081155) (PMID:37631074) (PMCID:PMC10459143)

2022

Timmers, M., Weterings, J., van Geijn, M., Bell, R., Lenting, P. E., Rijcken, C. J.F., Vermonden, T., Hennink, W. E. and Liskamp, R. M.J. (2022) A new class of tunable acid-sensitive linkers for native drug release based on the trityl protecting group. Bioconjugate Chemistry, 33(9), pp. 1707-1715. (doi: 10.1021/acs.bioconjchem.2c00310) (PMID:35979909) (PMCID:PMC9501768)

2021

Massett, M. E. et al. (2021) A KDM4A-PAF1-mediated epigenomic network is essential for acute myeloid leukemia cell self-renewal and survival. Cell Death and Disease, 12(6), 573. (doi: 10.1038/s41419-021-03738-0) (PMID:34083515) (PMCID:PMC8175737)

Meuleman, T. J., Cowton, V. M., Patel, A. H. and Liskamp, R. M.J. (2021) Design and synthesis of HCV-E2 glycoprotein epitope mimics in the molecular construction of potential as synthetic vaccines. Viruses, 13(2), 326. (doi: 10.3390/v13020326) (PMID:33672697) (PMCID:PMC7924389)

2020

Weterings, J., Rijcken, C. J.F., Veldhuis, H., Meulemans, T., Hadavi, D., Timmers, M., Honing, M., Ippel, H. and Liskamp, R. M.J. (2020) TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide-alkyne cycloaddition reactions. Chemical Science, 11(33), pp. 9011-9016. (doi: 10.1039/D0SC03477K) (PMID:34123155) (PMCID:PMC8163418)

Meuleman, T. J., Cowton, V. M., Patel, A. H. and Liskamp, R. M.J. (2020) Improving the aqueous solubility of HCV-E2 glycoprotein epitope mimics by cyclization using polar hinges. Journal of Peptide Science, 26(1), e3222. (doi: 10.1002/psc.3222) (PMID:31984607)

2019

Hoeksma, J. et al. (2019) A new perspective on fungal metabolites: identification of bioactive compounds from fungi using zebrafish embryogenesis as read-out. Scientific Reports, 9, 17546. (doi: 10.1038/s41598-019-54127-9) (PMID:31772307) (PMCID:PMC6879544)

Monaghan, L., Massett, M. E., Bunschoten, R. P., Hoose, A., Pirvan, P.-A., Liskamp, R. M.J. , Jørgensen, H. G. and Huang, X. (2019) The emerging role of H3K9me3 as a potential therapeutic target in acute myeloid leukaemia. Frontiers in Oncology, 9, 705. (doi: 10.3389/fonc.2019.00705) (PMID:31428579) (PMCID:PMC6687838)

Ward, D.J., Van de Langemheen, H., Koehne, E., Kreidenweiss, A. and Liskamp, R.M.J. (2019) Highly tunable thiosulfonates as a novel class of cysteine protease inhibitors with anti-parasitic activity against Schistosoma mansoni. Bioorganic and Medicinal Chemistry, 27(13), pp. 2857-2870. (doi: 10.1016/j.bmc.2019.05.014) (PMID:31126821)

Müskens, F. M., Ward, R. J., Herkt, D., van de Langemheen, H., Tobin, A. B. , Liskamp, R. M.J. and Milligan, G. (2019) Design, synthesis and evaluation of a diazirine photoaffinity probe for ligand-based receptor capture targeting G protein-coupled receptors. Molecular Pharmacology, 95(2), pp. 196-209. (doi: 10.1124/mol.118.114249) (PMID:30514721) (PMCID:PMC6324650)

Korotkovs, V., Reichenbach, L. F., Pescheteau, C., Burley, G. A. and Liskamp, R. M.J. (2019) Molecular construction of sulfonamide antisense oligonucleotides. Journal of Organic Chemistry, 84(17), pp. 10635-10648. (doi: 10.1021/acs.joc.9b00941)

2018

Guardiola, S., Prades, R., Mendieta, L., Brouwer, A. J., Streefkerk, J., Nevola, L., Tarragó, T., Liskamp, R. M.J. and Giralt, E. (2018) Targeted covalent inhibition of prolyl oligopeptidase (POP): discovery of sulfonylfluoride peptidomimetics. Cell Chemical Biology, 25(8), 1037-1037.e4. (doi: 10.1016/j.chembiol.2018.04.013) (PMID:29779956)

Longin, O., Hezwani, M., van de Langemheen, H. and Liskamp, R. M.J. (2018) Synthetic antibody protein mimics of infliximab by molecular scaffolding on novel CycloTriVeratrilene (CTV) derivatives. Organic and Biomolecular Chemistry, 16(29), pp. 5254-5274. (doi: 10.1039/c8ob01104d) (PMID:29892733)

Artschwager, R., Ward, D. J., Gannon, S., Brouwer, A. J., van de Langemheen, H., Kowalski, H. and Liskamp, R. M.J. (2018) Potent and highly selective inhibitors of the proteasome trypsin-like site by incorporation of basic side chain containing amino acid derived sulfonyl fluorides. Journal of Medicinal Chemistry, 61(12), pp. 5395-5411. (doi: 10.1021/acs.jmedchem.8b00685) (PMID:29782167)

Silva Nigenda, E., Postma, T., Hezwani, M., Pirvan, A., Gannon, S., Smith, C.-A. , Riehle, M. and Liskamp, R. M.J. (2018) Synthesis and cellular penetration properties of new phosphonium based cationic amphiphilic peptides. MedChemComm, 9(6), pp. 982-987. (doi: 10.1039/c8md00113h)

Morrison, S. D. , Liskamp, R. M.J. and Prunet, J. (2018) Tailoring polyethers for efficient post-polymerization functionalization by cross metathesis. Organic Letters, 20(8), pp. 2253-2256. (doi: 10.1021/acs.orglett.8b00595) (PMID:29600865)

Meuleman, T. J., Dunlop, J. I., Owsianka, A. M., van de Langemheen, H., Patel, A. H. and Liskamp, R. M.J. (2018) Immobilization by surface conjugation of cyclic peptides for effective mimicry of the HCV-envelope E2 protein as a strategy toward synthetic vaccines. Bioconjugate Chemistry, 29(4), pp. 1091-1101. (doi: 10.1021/acs.bioconjchem.7b00755) (PMID:29382188)

2017

Yang, X., Beroske, L. P., Kemmink, J., Rijkers, D. T.S. and Liskamp, R. M.J. (2017) Synthesis of bicyclic tripeptides inspired by the ABC-ring system of vancomycin through ruthenium-based cyclization chemistries. Tetrahedron Letters, 58(48), pp. 4542-4546. (doi: 10.1016/j.tetlet.2017.10.046)

Herrero Alvarez, N., Van De Langemheen, H., Brouwer, A. J. and Liskamp, R. M.J. (2017) Potential peptidic proteasome inhibitors by incorporation of an electrophilic trap based on amino acid derived α-substituted sulfonyl fluorides. Bioorganic and Medicinal Chemistry, 25(19), pp. 5055-5063. (doi: 10.1016/j.bmc.2017.07.019) (PMID:28734665)

Longin, O., Van De Langemheen, H. and Liskamp, R. M.J. (2017) An orthogonally protected CycloTriVeratrylene (CTV) as a highly pre-organized molecular scaffold for subsequent ligation of different cyclic peptides towards protein mimics. Bioorganic and Medicinal Chemistry, 25(18), pp. 5008-5015. (doi: 10.1016/j.bmc.2017.05.038) (PMID:28583807)

Van De Langemheen, H., Korotkovs, V., Bijl, J., Wilson, C. , Kale, S. S., Heinis, C. and Liskamp, R. M.J. (2017) Polar hinges as functionalized conformational constraints in (bi)cyclic peptides. ChemBioChem, 18(4), pp. 387-395. (doi: 10.1002/cbic.201600612) (PMID:27982494)

2016

O'Connor, C. et al. (2016) The presence of C/EBPα and its degradation are both required for TRIB2 mediated leukaemia. Oncogene, 35(40), pp. 5272-5281. (doi: 10.1038/onc.2016.66) (PMID:26996668)

Brouwer, A. J., Herrero Álvarez, N., Ciaffoni, A., van de Langemheen, H. and Liskamp, R. M.J. (2016) Proteasome inhibition by new dual warhead containing peptido vinyl sulfonyl fluorides. Bioorganic and Medicinal Chemistry, 24(16), pp. 3429-3435. (doi: 10.1016/j.bmc.2016.05.042) (PMID:27316540)

Hovestad-Bijl, L., van Ameijde, J., Pijnenburg, D., Hilhorst, R., Liskamp, R. and Ruijtenbeek, R. (2016) Peptide microarrays for real-time kinetic profiling of tyrosine phosphatase activity of recombinant phosphatases and phosphatases in lysates of cells or tissue samples. In: Pulido, R. (ed.) Protein Tyrosine Phosphatases: Methods and Protocols. Series: Methods in molecular biology, 1447 (1447). Springer New York, pp. 67-78. ISBN 9781493937448 (doi: 10.1007/978-1-4939-3746-2_4)

Armfield, K., Liskamp, R. and Wilson, J.B. (2016) Therapeutic Approaches to Targetting Epstein-Barr Virus Related Disease. Structural Aspects of Infectious Disease, Cambridge, UK, 08-10 Aug 2016.

Postma, T.M. and Liskamp, R.M.J. (2016) Highly potent antimicrobial peptide derivatives of bovine cateslytin. RSC Advances, 6(97), pp. 94840-94844. (doi: 10.1039/c6ra17944d)

Postma, T.M. and Liskamp, R.M.J. (2016) Triple-targeting Gram-negative selective antimicrobial peptides capable of disrupting the cell membrane and lipid A biosynthesis. RSC Advances, 6(70), pp. 65418-65421. (doi: 10.1039/c6ra11550k)

Werkhoven, P.R., Elwakiel, M., Meuleman, T.J., Quarles van Ufford, H.C., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2016) Molecular construction of HIV-gp120 discontinuous epitope mimics by assembly of cyclic peptides on an orthogonal alkyne functionalized TAC-scaffold. Organic and Biomolecular Chemistry, 14(2), pp. 701-710. (doi: 10.1039/c5ob02014j) (PMID:26552661)

2015

Gilfillan, L., Artschwager, R., Harkiss, A. H., Liskamp, R. M.J. and Sutherland, A. (2015) Synthesis of pyrazole containing α-amino acids via a highly regioselective condensation/aza-Michael reaction of β-aryl α,β-unsaturated ketones. Organic and Biomolecular Chemistry, 13(15), pp. 4514-4523. (doi: 10.1039/C5OB00364D) (PMID:25774874)

2014

Dubiella, C., Cui, H., Gersch, M., Brouwer, A. J., Sieber, S. A., Krüger, A., Liskamp, R. M.J. and Groll, M. (2014) Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site. Angewandte Chemie (International Edition), 53(44), pp. 11969-11973. (doi: 10.1002/anie.201406964) (PMID:25244435)

Harmsen, R. A.G., Ghalit, N., Kemmink, J., Breukink, E., Liskamp, R. M.J. and Rijkers, D. T.S. (2014) A conformationally constrained fused tricyclic nisin AB-ring system mimic toward an improved pyrophosphate binder of lipid II. Tetrahedron, 70(42), pp. 7691-7699. (doi: 10.1016/j.tet.2014.06.023)

Slootweg, J. C., Peters, N., Quarles van Ufford, H. (L.) C., Breukink, E., Liskamp, R. M.J. and Rijkers, D. T.S. (2014) Semi-synthesis of biologically active nisin hybrids composed of the native lanthionine ABC-fragment and a cross-stapled synthetic DE-fragment. Bioorganic and Medicinal Chemistry, 22(19), pp. 5345-5353. (doi: 10.1016/j.bmc.2014.07.046) (PMID:25199583)

Brouwer, A. J., Van De Langemheen, H. and Liskamp, R. M.J. (2014) Expedient synthesis of a novel asymmetric selectively deprotectable derivative of the ATAC scaffold. Tetrahedron, 70(26), pp. 4002-4007. (doi: 10.1016/j.tet.2014.04.084)

Brouwer, A. J., van de Langemheen, H., Ciaffoni, A., Schilder, K. E. and Liskamp, R. M.J. (2014) Synthesis of the TACO scaffold as a new selectively deprotectable conformationally restricted triazacyclophane based scaffold. Organic Letters, 16(11), pp. 3106-3109. (doi: 10.1021/ol5012218) (PMID:24856258)

González-Ortiz, G., Quarles Van Ufford, H. C., Halkes, S. B. A., Cerdà-Cuéllar, M., Beukelman, C. J., Pieters, R. J., Liskamp, R. M. J. , Pérez, J. F. and Martín-Orue, S. M. (2014) New properties of wheat bran: anti-biofilm activity and interference with bacteria quorum-sensing systems. Environmental Microbiology, 16(5), pp. 1346-1353. (doi: 10.1111/1462-2920.12441)

van de Langemheen, H., Quarles van Ufford, H. (L.) C., Kruijtzer, J. A. W. and Liskamp, R. M.J. (2014) Efficient synthesis of protein mimics by sequential native chemical ligation. Organic Letters, 16(8), pp. 2138-2141. (doi: 10.1021/ol500604h)

Werkhoven, P. R., van de Langemheen, H., van der Wal, S., Kruijtzer, J. A. W. and Liskamp, R. M.J. (2014) Versatile convergent synthesis of a three peptide loop containing protein mimic of whooping cough pertactin by successive Cu(I)-catalyzed azide alkyne cycloaddition on an orthogonal alkyne functionalized TAC-scaffold. Journal of Peptide Science, 20(4), pp. 235-239. (doi: 10.1002/psc.2624) (PMID:24599619)

van Ameijde, J., Overvoorde, J., Knapp, S., den Hertog, J., Ruijtenbeek, R. and Liskamp, R. M.J. (2014) A versatile spectrophotometric protein tyrosine phosphatase assay based on 3-nitrophosphotyrosine containing substrates. Analytical Biochemistry, 448, pp. 9-13. (doi: 10.1016/j.ab.2013.11.023)

van Ameijde, J., Zwiebel, A. P. R., Ruijtenbeek, R. and Liskamp, R. M. J. (2014) Azide–alkyne cycloaddition affording enzymatically tunable bisubstrate based inhibitors of histone acetyltransferase PCAF. Bioorganic and Medicinal Chemistry Letters, 24(1), pp. 113-116. (doi: 10.1016/j.bmcl.2013.11.060)

van der Wal, S., Fu, O., Rontogianni, S., Pieters, R. and Liskamp, R. M. J. (2014) Convenient stereoselective synthesis of substituted ureido glycosides using stable 4-chlorophenylcarbamates without the requirement of lewis acids. Synlett, 25(02), pp. 205-208. (doi: 10.1055/s-0033-1340220)

Cleophas, R. T.C., Riool, M., Quarles van Ufford, H. (L.) C., Zaat, S. A.J., Kruijtzer, J. A.W. and Liskamp, R. M.J. (2014) Convenient preparation of bactericidal hydrogels by covalent attachment of stabilized antimicrobial peptides using thiol–ene click chemistry. ACS Macro Letters, 3(5), pp. 477-480. (doi: 10.1021/mz5001465)

Cleophas, R. T.C., Sjollema, J., Busscher, H. J., Kruijtzer, J. A.W. and Liskamp, R. M.J. (2014) Characterization and activity of an immobilized antimicrobial peptide containing bactericidal PEG-hydrogel. Biomacromolecules, 15(9), pp. 3390-3395. (doi: 10.1021/bm500899r) (PMID:25109707)

van de Langemheen, H., van Hoeke, M., Quarles van Ufford, H.C., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2014) Scaffolded multiple cyclic peptide libraries for protein mimics by native chemical ligation. Organic and Biomolecular Chemistry, 12(25), pp. 4471-4478. (doi: 10.1039/c4ob00190g) (PMID:24849139)

van der Wal, S., Capicciotti, C. J., Rontogianni, S., Ben, R. N. and Liskamp, R. M.J. (2014) Synthesis and evaluation of linear CuAAC-oligomerized antifreeze neo-glycopeptides. MedChemComm, 5(8), pp. 1159-1165. (doi: 10.1039/c4md00013g)

2013

Slootweg, J. C., van der Wal, S., Quarles van Ufford, H. C., Breukink, E., Liskamp, R. M. J. and Rijkers, D. T. S. (2013) Synthesis, antimicrobial activity, and membrane permeabilizing properties of C-terminally modified nisin conjugates accessed by CuAAC. Bioconjugate Chemistry, 24(12), pp. 2058-2066. (doi: 10.1021/bc400401k)

Slootweg, J. C., Kemmink, J., Liskamp, R. M. J. and Rijkers, D. T. S. (2013) Synthesis and structural characterization of the individual diastereoisomers of a cross-stapled alkene-bridged nisin DE-ring mimic. Organic and Biomolecular Chemistry, 11(43), pp. 7486-7496. (doi: 10.1039/c3ob41359d)

Slootweg, J. C., Liskamp, R. M. J. and Rijkers, D. T. S. (2013) Scalable purification of the lantibiotic nisin and isolation of chemical/enzymatic cleavage fragments suitable for semi-synthesis. Journal of Peptide Science, 19(11), pp. 692-699. (doi: 10.1002/psc.2551)

van Ameijde, J., Overvoorde, J., Knapp, S., den Hertog, J., Ruijtenbeek, R. and Liskamp, R. M. J. (2013) Real-time monitoring of the dephosphorylating activity of protein tyrosine phosphatases using microarrays with 3-nitrophosphotyrosine substrates. ChemPlusChem, 78(11), pp. 1349-1357. (doi: 10.1002/cplu.201300299)

Tschan, S. et al. (2013) Broad-spectrum antimalarial activity of peptido sulfonyl fluorides, a new class of proteasome inhibitors. Antimicrobial Agents and Chemotherapy, 57(8), pp. 3576-3584. (doi: 10.1128/AAC.00742-12)

van Wandelen, L. T. M., van Ameijde, J., Ismail-Ali, A. F., van Ufford, H. C. (L.) Q., Vijftigschild, L. A. W., Beekman, J. M., Martin, N. I., Ruijtenbeek, R. and Liskamp, R. M. J. (2013) Cell-penetrating bisubstrate-based protein kinase C inhibitors. ACS Chemical Biology, 8(7), pp. 1479-1487. (doi: 10.1021/cb300709g)

Slootweg, J. C., van Schaik, T. B., Quarles van Ufford, H. (L.) C., Breukink, E., Liskamp, R. M. J. and Rijkers, D. T.S. (2013) Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative. Bioorganic and Medicinal Chemistry Letters, 23(13), pp. 3749-3752. (doi: 10.1016/j.bmcl.2013.05.002)

Zhang, J., Kemmink, J., Rijkers, D. T. S. and Liskamp, R. M. J. (2013) Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization. Chemical Communications, 49(40), pp. 4498-4500. (doi: 10.1039/c3cc40628h)

Mulder, G. E., Quarles van Ufford, H. (L.). C., van Ameijde, J., Brouwer, A. J., Kruijtzer, J. A. W. and Liskamp, R. M. J. (2013) Scaffold optimization in discontinuous epitope containing protein mimics of gp120 using smart libraries. Organic and Biomolecular Chemistry, 11(16), pp. 2676-2684. (doi: 10.1039/c3ob27470e)

Vosyka, O., Vinothkumar, K.R., Wolf, E.V., Brouwer, A.J., Liskamp, R.M.J. and Verhelst, S.H.L. (2013) Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay. Proceedings of the National Academy of Sciences of the United States of America, 110(7), pp. 2472-2477. (doi: 10.1073/pnas.1215076110)

Nuijens, T., Schepers, A.H.M., Cusan, C., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2013) Enzymatic fragment condensation of side chain-protected peptides using subtilisin A in anhydrous organic solvents: a general strategy for industrial peptide synthesis. Advanced Synthesis & Catalysis, 355(2-3), pp. 287-293. (doi: 10.1002/adsc.201200694)

de Mol, N.J., Kruijtzer, J.A.W., Moret, E.E., Broutin, I. and Liskamp, R.M.J. (2013) Unusual binding of Grb2 protein to a bivalent polyproline-ligand immobilized on a SPR sensor: intermolecular bivalent binding. Biochimica et Biophysica Acta: Proteins and Proteomics, 1834(2), pp. 524-535. (doi: 10.1016/j.bbapap.2012.11.001)

Werkhoven, P. R. and Liskamp, R. M.J. (2013) Chemical approaches for localization, characterization and mimicry of peptide epitopes. In: Jones, L. H. and McKnight, A. J. (eds.) Biotherapeutics: Recent Developments using Chemical and Molecular Biology. Series: RSC Drug Discovery Series (36). The Royal Society of Chemistry: Cambridge, pp. 263-284. ISBN 9781849736015 (doi: 10.1039/9781849737159)

2012

van Wandelen, L.T.M., van Ameijde, J., Mady, A.S.A., Wammes, A.E.M., Bode, A., Poot, A.J., Ruijtenbeek, R. and Liskamp, R.M.J. (2012) Directed modulation of protein kinase C isozyme selectivity with bisubstrate-based inhibitors. ChemMedChem, 7(12), pp. 2113-2121. (doi: 10.1002/cmdc.201200349)

Pamgene B.V. University of Utrecht Holding B.V. (2012) New Modified Tyrosine Amino Acid Comprising Substituted 2-Methyl-3-Phenyl-Propionic Acid Compounds, Useful in Synthetic Peptide and Array, for Detecting Hydrolase Enzyme Activity E.G. Phosphatase and EC 3.1, and Peptide Synthesis. .

van de Langemheen, H., Brouwer, A.J., Kemmink, J., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2012) Synthesis of cyclic peptides containing a thioester handle for native chemical ligation. Journal of Organic Chemistry, 77(22), pp. 10058-10064. (doi: 10.1021/jo3015566)

Shinde, S., Bunschoten, A., Kruijtzer, J.A.W., Liskamp, R.M.J. and Sellergren, B. (2012) Imprinted polymers displaying high affinity for sulfated protein fragments. Angewandte Chemie (International Edition), 51(33), pp. 8326-8329. (doi: 10.1002/anie.201201314)

Mulder, M.P.C., Fodran, P., Kemmink, J., Breukink, E.J., Kruijtzer, J.A.W., Minnaard, A.J. and Liskamp, R.M.J. (2012) Mutual influence of backbone proline substitution and lipophilic tail character on the biological activity of simplified analogues of caspofungin. Organic and Biomolecular Chemistry, 10(37), pp. 7491-7502. (doi: 10.1039/c2ob25951f)

Nuijens, T., Piva, E., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2012) Enzymatic C-terminal amidation of amino acids and peptides. Tetrahedron Letters, 53(29), pp. 3777-3779. (doi: 10.1016/j.tetlet.2012.05.039)

Crielaard, B.J. et al. (2012) Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angewandte Chemie (International Edition), 51(29), pp. 7254-7258. (doi: 10.1002/anie.201202713)

Görmer, K., Bürger, M., Kruijtzer, J.A.W., Vetter, I., Vartak, N., Brunsveld, L., Bastiaens, P.I.H., Liskamp, R.M.J. , Triola, G. and Waldmann, H. (2012) Chemical-biological exploration of the limits of the ras de- and repalmitoylating machinery. ChemBioChem, 13(7), pp. 1017-1023. (doi: 10.1002/cbic.201200078)

University of Utrecht Holding B.V. (2012) New Linker Comprising Hydroxyl Containing or an Amine Containing Moiety, Preferably A Hydroxyl Group or Carboxylic Acid Moiety, Dialkylation of Sulfur Atom and Conjugation Moiety, Useful in Drug Delivery System for Treating E.G. Cancer. .

de Graaf, A.J., Mastrobattista, E., Vermonden, T., van Nostrum, C., Rijkers, D.T.S., Liskamp, R.M.J. and Hennink, W.E. (2012) Thermosensitive peptide-hybrid ABC block copolymers obtained by ATRP: synthesis, self-assembly, and enzymatic degradation. Macromolecules, 45(2), pp. 842-851. (doi: 10.1021/ma2024667)

Albada, H.B., Soulimani, F., Jacobs, H.J.F., Versluis, C., Weckhuysen, B.M. and Liskamp, R.M.J. (2012) Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites. Organic and Biomolecular Chemistry, 10(5), pp. 1088-1092. (doi: 10.1039/c1ob06806g)

Arnusch, C.J., Albada, H.B., van Vaardegem, M., Liskamp, R.M.J. , Sahl, H.-G., Shadkchan, Y., Osherov, N. and Shai, Y. (2012) Trivalent ultrashort lipopeptides are potent pH dependent antifungal agents. Journal of Medicinal Chemistry, 55(3), pp. 1296-1302. (doi: 10.1021/jm2014474)

Brouwer, A.J. et al. (2012) Peptido sulfonyl fluorides as new powerful proteasome inhibitors. Journal of Medicinal Chemistry, 55(24), pp. 10995-11003. (doi: 10.1021/jm301443r)

Mulder, G.E., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2012) A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold. Chemical Communications, 48(80), p. 10007. (doi: 10.1039/c2cc35310e)

2011

Rijkers, D.T.S., de Prada López, F., Liskamp, R.M.J. and Diederich, F. (2011) A convenient [2+2] cycloaddition–cycloreversion reaction for the synthesis of 1,1-dicyanobuta-1,3-diene-scaffolded peptides as new imaging chromophores. Tetrahedron Letters, 52(51), pp. 6963-6967. (doi: 10.1016/j.tetlet.2011.10.084)

Mulder, M.P.C., Kruijtzer, J.A.W., Breukink, E.J., Kemmink, J., Pieters, R.J. and Liskamp, R.M.J. (2011) Synthesis and evaluation of novel macrocyclic antifungal peptides. Bioorganic and Medicinal Chemistry, 19(21), pp. 6505-6517. (doi: 10.1016/j.bmc.2011.08.034)

Nyholm, T.K.M., van Duyl, B., Rijkers, D.T.S., Liskamp, R.M.J. and Killian, J.A. (2011) Probing the lipid-protein interface using model transmembrane peptides with a covalently linked acyl chain. Biophysical Journal, 101(8), pp. 1959-1967. (doi: 10.1016/j.bpj.2011.09.020)

Liskamp, R.M.J. and Brouwer, A. (2011) A simple large-scale synthesis of Cbz-protected taurylsulfonyl azide. Synlett, 2011(15), pp. 2228-2230. (doi: 10.1055/s-0030-1261201)

Liskamp, R.M.J. , Rijkers, D.T.S., Kruijtzer, J.A.W. and Kemmink, J. (2011) Peptides and proteins as a continuing exciting source of inspiration for peptidomimetics. ChemBioChem, 15, pp. 2228-2230. (doi: 10.1002/cbic.201000717)

Nuijens, T., Cusan, C., Schepers, A.C.H.M., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2011) Enzymatic synthesis of activated esters and their subsequent use in enzyme-based peptide synthesis. Journal of Molecular Catalysis B: Enzymatic, 71(1-2), pp. 79-84. (doi: 10.1016/j.molcatb.2011.03.012)

Nuijens, T., Piva, E., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2011) Fully enzymatic N→C-directed peptide synthesis using C-terminal peptide α-carboxamide to ester interconversion. Advanced Synthesis & Catalysis, 353(7), pp. 1039-1044. (doi: 10.1002/adsc.201000943)

Brouwer, A.J., Ceylan, T., Jonker, A.M., Linden, T. and Liskamp, R.M.J. (2011) Synthesis and biological evaluation of novel irreversible serine protease inhibitors using amino acid based sulfonyl fluorides as an electrophilic trap. Bioorganic and Medicinal Chemistry, 19(7), pp. 2397-2406. (doi: 10.1016/j.bmc.2011.02.014)

Yim, C.-B., van der Wildt, B., Dijkgraaf, I., Joosten, L., Eek, A., Versluis, C., Rijkers, D.T.S., Boerman, O.C. and Liskamp, R.M.J. (2011) Spacer effects on in vivo properties of DOTA-conjugated dimeric [Tyr3]octreotate peptides synthesized by a “CuI-Click” and “Sulfo-Click” ligation method. ChemBioChem, 12(5), pp. 750-760. (doi: 10.1002/cbic.201000639)

Bauke Albada, H., Rosati, F., Coquière, D., Roelfes, G. and Liskamp, R.M.J. (2011) Enantioselective cuII-catalyzed diels-alder and michael addition reactions in water using bio-inspired triazacyclophane-based ligands. European Journal of Organic Chemistry, 2011(9), pp. 1714-1720. (doi: 10.1002/ejoc.201001522)

Bunschoten, A., Ippel, J.H., Kruijtzer, J.A.W., Feitsma, L., Haas, C.J.C., Liskamp, R.M.J. and Kemmink, J. (2011) A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds. Amino Acids, 40(2), pp. 731-740. (doi: 10.1007/s00726-010-0711-3)

Kuil, J., Fischer, M.J.E., de Mol, N.J. and Liskamp, R.M.J. (2011) Cell permeable ITAM constructs for the modulation of mediator release in mast cells. Organic and Biomolecular Chemistry, 9(3), p. 820. (doi: 10.1039/c0ob00441c)

Zhang, J., Kemmink, J., Rijkers, D.T.S. and Liskamp, R.M.J. (2011) Cu(I)- and Ru(II)-mediated “click” cyclization of tripeptides toward vancomycin-inspired mimics. Organic Letters, 13(13), pp. 3438-3441. (doi: 10.1021/ol201184b)

2010

Nuijens, T., Cusan, C., van Dooren, T.J.G.M., Moody, H.M., Merkx, R., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2010) Fully enzymatic peptide synthesis using C-terminal tert-butyl ester interconversion. Advanced Synthesis & Catalysis, 352(14-15), pp. 2399-2404. (doi: 10.1002/adsc.201000313)

Parera Pera, N., Branderhorst, H.M., Kooij, R., Maierhofer, C., van der Kaaden, M., Liskamp, R.M.J. , Wittmann, V., Ruijtenbeek, R. and Pieters, R.J. (2010) Rapid screening of lectins for multivalency effects with a glycodendrimer microarray. ChemBioChem, 11(13), pp. 1896-1904. (doi: 10.1002/cbic.201000340)

Khemtémourian, L., Engel, M.F.M., Liskamp, R.M.J. , Höppener, J.W.M. and Killian, J.A. (2010) The N-terminal fragment of human islet amyloid polypeptide is non-fibrillogenic in the presence of membranes and does not cause leakage of bilayers of physiologically relevant lipid composition. Biochimica et Biophysica Acta: Biomembranes, 1798(9), pp. 1805-1811. (doi: 10.1016/j.bbamem.2010.05.022)

Khemtémourian, L., Engel, M.F.M., Kruijtzer, J.A.W., Höppener, J.W.M., Liskamp, R.M.J. and Killian, J.A. (2010) The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes. European Biophysics Journal with Biophysics Letters, 39(9), pp. 1359-1364. (doi: 10.1007/s00249-009-0572-4)

Arnusch, C.J., Ippel, J.H., Kooijman, H., Spek, A.L., Liskamp, R.M.J. , Kemmink, J. and Pieters, R.J. (2010) Direct structural comparison of a rigid cyclic peptidic scaffold using crystallography and NMR in strained PH polymer gels. European Journal of Organic Chemistry, 2010(23), pp. 4501-4507. (doi: 10.1002/ejoc.201000440)

Dekker, F.J., DE Mol, N.J. and Liskamp, R.M.J. (2010) Thermodynamics of phosphotyrosine peptide-peptoid hybrids binding to the p56^lck SH2 domain. Journal of Peptide Science, 16(7), pp. 322-328. (doi: 10.1002/psc.1242)

Bunschoten, A., Feitsma, L.J., Kruijtzer, J.A.W., de Haas, C.J.C., Liskamp, R.M.J. and Kemmink, J. (2010) CHIPS binds to the phosphorylated N-terminus of the C5a-receptor. Bioorganic and Medicinal Chemistry Letters, 20(11), pp. 3338-3340. (doi: 10.1016/j.bmcl.2010.04.028)

van Dijk, M., Postma, T.M., Rijkers, D.T.S., Liskamp, R.M.J. , van Nostrum, C.F. and Hennink, W.E. (2010) Synthesis and characterization of tailorable biodegradable thermoresponsive methacryloylamide polymers based on l-serine and l-threonine alkyl esters. Polymer, 51(12), pp. 2479-2485. (doi: 10.1016/j.polymer.2010.04.010)

van Ameijde, J., Slot, T.K. and Liskamp, R.M.J. (2010) Towards the synthesis of sulfonamide-based RNA mimetics. Tetrahedron: Asymmetry, 21(4), pp. 469-475. (doi: 10.1016/j.tetasy.2010.02.005)

van Scherpenzeel, M., van den Berg, R.J.B.H.N., Donker-Koopman, W.E., Liskamp, R.M.J. , Aerts, J.M.F.G., Overkleeft, H.S. and Pieters, R.J. (2010) Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase. Bioorganic and Medicinal Chemistry, 18(1), pp. 267-273. (doi: 10.1016/j.bmc.2009.10.060)

Pera, N.P., Kouki, A., Haataja, S., Branderhorst, H.M., Liskamp, R.M.J. , Visser, G.M., Finne, J. and Pieters, R.J. (2010) Detection of pathogenic streptococcus suis bacteria using magnetic glycoparticles. Organic and Biomolecular Chemistry, 8, pp. 2425-2429. (doi: 10.1039/c000819b)

van Ameijde, J., Poot, A.J., van Wandelen, L.T.M., Wammes, A.E.M., Ruijtenbeek, R., Rijkers, D.T.S. and Liskamp, R.M.J. (2010) Preparation of novel alkylated arginine derivatives suitable for click-cycloaddition chemistry and their incorporation into pseudosubstrate- and bisubstrate-based kinase inhibitors. Organic and Biomolecular Chemistry, 8(7), pp. 1629-1639. (doi: 10.1039/b922928k)

van Dijk, M., van Nostrum, C.F., Hennink, W.E., Rijkers, D.T.S. and Liskamp, R.M.J. (2010) Synthesis and characterization of enzymatically biodegradable PEG and peptide-based hydrogels prepared by click chemistry. Biomacromolecules, 11(6), pp. 1608-1614. (doi: 10.1021/bm1002637)

Yim, C.-B., Dijkgraaf, I., Merkx, R., Versluis, C., Eek, A., Mulder, G.E., Rijkers, D.T.S., Boerman, O.C. and Liskamp, R.M.J. (2010) Synthesis of DOTA-conjugated multimeric [Tyr3]octreotide peptides via a combination of Cu(I)-catalyzed "click" cycloaddition and thio acid/sulfonyl azide "sulfo-Click" Amidation and Their in Vivo Evaluation. Journal of Medicinal Chemistry, 53(10), pp. 3944-3953. (doi: 10.1021/jm100246m)

2009

Kuil, J., van Wandelen, L.T.M., de Mol, N.J. and Liskamp, R.M.J. (2009) Switching between low and high affinity for the Syk tandem SH2 domain by irradiation of azobenzene containing ITAM peptidomimetics. Journal of Peptide Science, 15(10), pp. 685-691. (doi: 10.1002/psc.1173)

Poot, A.J., van Ameijde, J., Slijper, M., van den Berg, A., Hilhorst, R., Ruijtenbeek, R., Rijkers, D.T.S. and Liskamp, R.M.J. (2009) Development of selective bisubstrate-based inhibitors against protein kinase C (PKC) isozymes by using dynamic peptide microarrays. ChemBioChem, 10(12), pp. 2042-2051. (doi: 10.1002/cbic.200900199)

Bauke Albada, H., Arnusch, C.J., Branderhorst, H.M., Verel, A.-M., Janssen, W.T.M., Breukink, E., de Kruijff, B., Pieters, R.J. and Liskamp, R.M.J. (2009) Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin–TACzyme conjugates and modulation of their antibacterial activity by Zn-ions. Bioorganic and Medicinal Chemistry Letters, 19(14), pp. 3721-3724. (doi: 10.1016/j.bmcl.2009.05.064)

van Scherpenzeel, M., Moret, E.E., Ballell, L., Liskamp, R.M.J. , Nilsson, U.J., Leffler, H. and Pieters, R.J. (2009) Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3. ChemBioChem, 10(10), pp. 1724-1733. (doi: 10.1002/cbic.200900198)

Brouwer, A.J., Ceylan, T., van der Linden, T. and Liskamp, R.M.J. (2009) Synthesis of β-aminoethanesulfonyl fluorides or 2-substituted taurine sulfonyl fluorides as potential protease inhibitors. Tetrahedron Letters, 50(26), pp. 3391-3393. (doi: 10.1016/j.tetlet.2009.02.130)

Nuijens, T., Kruijtzer, J.A.W., Cusan, C., Rijkers, D.T.S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2009) A versatile and selective chemo-enzymatic synthesis of β-protected aspartic and γ-protected glutamic acid derivatives. Tetrahedron Letters, 50(23), pp. 2719-2721. (doi: 10.1016/j.tetlet.2009.03.130)

Ippel, J.H., de Haas, C.J.C., Bunschoten, A., van Strijp, J.A.G., Kruijtzer, J.A.W., Liskamp, R.M.J. and Kemmink, J. (2009) Structure of the tyrosine-sulfated C5a receptor N terminus in complex with chemotaxis inhibitory protein of Staphylococcus aureus. Journal of Biological Chemistry, 284(18), pp. 12363-12372. (doi: 10.1074/jbc.M808179200)

Teertstra, W.R., van der Velden, G.J., de Jong, J.F., Kruijtzer, J.A.W., Liskamp, R.M.J. , Kroon-Batenburg, L.M.J., Muller, W.H., Gebbink, M.F.B.G. and Wosten, H.A.B. (2009) The filament-specific Rep1-1 repellent of the phytopathogen ustilago maydis forms functional surface-active amyloid-like fibrils. Journal of Biological Chemistry, 284(14), pp. 9153-9159. (doi: 10.1074/jbc.M900095200)

Gubbens, J., Ruijter, E., de Fays, L.E.V., Damen, J.M.A., de Kruijff, B., Slijper, M., Rijkers, D.T.S., Liskamp, R.M.J. and de Kroon, A.I.P.M. (2009) Photocrosslinking and click chemistry enable the specific detection of proteins interacting with phospholipids at the membrane interface. Chemistry and Biology, 16(1), pp. 3-14. (doi: 10.1016/j.chembiol.2008.11.009)

University of Rotterdam Erasmus Cent Medical (2009) New Compound Having Multivalent Binding Capacity for Protein and Comprising Oligosaccharide Moieties Linked to a Dendrimer, Useful For Detecting Cholera Toxin and Treating Intoxication With Bacterial Toxin and Autoimmune Neuropathy. .

Bunschoten, A., Kruijtzer, J.A.W., Ippel, J.H., de Haas, C.J.C., van Strijp, J.A.G., Kemmink, J. and Liskamp, R.M.J. (2009) A general sequence independent solid phase method for the site specific synthesis of multiple sulfated-tyrosine containing peptides. Chemical Communications(21), pp. 2999-3001. (doi: 10.1039/b823425f)

Chamorro, C., Kruijtzer, J.A.W., Farsaraki, M., Balzarini, J. and Liskamp, R.M.J. (2009) A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes. Chemical Communications(7), pp. 821-823. (doi: 10.1039/b817357e)

Elgersma, R.C., Rijkers, D.T.S. and Liskamp, R.M.J. (2009) pH Controlled aggregation morphology of Aβ(16–22): formation of peptide nanotubes, helical tapes and amyloid fibrils. In: Del Valle, S., Escher, E. and Lubell, W. D. (eds.) Peptides for Youth: The Proceedings of the 20th American Peptide Symposium. Series: Advances in Experimental Medicine and Biology (611). Springer New York, pp. 239-240. ISBN 9780387736563 (doi: 10.1007/978-0-387-73657-0_109)

Elgersma, R.C., van Dijk, M., Dechesne, A.C., van Nostrum, C.F., Hennink, W.E., Rijkers, D.T.S. and Liskamp, R.M.J. (2009) Microwave-assisted click polymerization for the synthesis of Aβ(16–22) cyclic oligomers and their self-assembly into polymorphous aggregates. Organic and Biomolecular Chemistry, 7(21), pp. 4517-4525. (doi: 10.1039/b912851d)

Harmsen, R.A.G., Ghalit, N., Kemmink, J., Hilbers, H.W., Breukink, E., Rijkers, D.T.S. and Liskamp, R.M.J. (2009) Alkene/alkane bridged mimics of the lantibiotic nisin: toward novel peptide-based antibiotics. In: Peptides for Youth. Series: Advances in Experimental Medicine and Biology, 611. Springer, pp. 533-534. ISBN 9780387736563 (doi: 10.1007/978-0-387-73657-0_233)

Kuil, J., Branderhorst, H.M., Pieters, R.J., de Mol, N.J. and Liskamp, R.M.J. (2009) ITAM-derived phosphopeptide-containing dendrimers as multivalent ligands for Syk tandem SH2 domain. Organic and Biomolecular Chemistry, 7(19), pp. 4088-4094. (doi: 10.1039/b905938e)

Kuil, J., van Wandelen, L.T. M., de Mol, N.J. and Liskamp, R.M.J. (2009) Peptidomimetic ligands for the tandem SH2 domain of the syk protein involved in signal transduction. In: Peptides for Youth. Series: Advances in Experimental Medicine and Biology, 611. Springer, pp. 81-82. ISBN 9780387736563 (doi: 10.1007/978-0-387-73657-0_36)

Nuijens, T., Cusan, C., Kruijtzer, J.A.W., Rijkers, D.T. S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2009) Enzymatic synthesis of c-terminal arylamides of amino acids and peptides. Journal of Organic Chemistry, 74(15), pp. 5145-5150. (doi: 10.1021/jo900634g)

Nuijens, T., Cusan, C., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2009) Versatile selective α-carboxylic acid esterification of N-protected amino acids and peptides by alcalase. Synthesis, 2009(5), pp. 809-814. (doi: 10.1055/s-0028-1083362)

van Dijk, M., Rijkers, D.T.S., Liskamp, R.M.J. , van Nostrum, C.F. and Hennink, W.E. (2009) Synthesis and applications of biomedical and pharmaceutical polymers via click chemistry methodologies. Bioconjugate Chemistry, 20(11), pp. 2001-2016. (doi: 10.1021/bc900087a)

Yim, C.-B., Boerman, O.C., de Visser, M., de Jong, M., Dechesne, A.C., Rijkers, D.T.S. and Liskamp, R.M.J. (2009) Versatile conjugation of octreotide to dendrimers by cycloaddition (“click”) chemistry to yield high-affinity multivalent cyclic peptide dendrimers. Bioconjugate Chemistry, 20(7), pp. 1323-1331. (doi: 10.1021/bc900052n)

2008

van Ingen, H., van Schaik, F.M.A., Wienk, H., Ballering, J., Rehmann, H., Dechesne, A.C., Kruijzer, J.A.W., Liskamp, R.M.J. , Timmers, H.T.M. and Boelens, R. (2008) Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3. Structure, 16(8), pp. 1245-1256. (doi: 10.1016/j.str.2008.04.015)

Branderhorst, H.M., Ruijtenbeek, R., Liskamp, R.M.J. and Pieters, R.J. (2008) Multivalent carbohydrate recognition on a glycodendrimer‐functionalized flow‐through chip. ChemBioChem, 9(11), pp. 1836-1844. (doi: 10.1002/cbic.200800195)

Özdirekcan, S., Nyholm, T.K.M., Raja, M., Rijkers, D.T.S., Liskamp, R.M.J. and Killian, J.A. (2008) Influence of trifluoroethanol on membrane interfacial anchoring interactions of transmembrane α-helical peptides. Biophysical Journal, 94(4), pp. 1315-1325. (doi: 10.1529/biophysj.106.101782)

Elgersma, R.C., Mulder, G.E., Posthuma, G., Rijkers, D.T.S. and Liskamp, R.M.J. (2008) Mirror image supramolecular helical tapes formed by the enantiomeric-depsipeptide derivatives of the amyloidogenic peptide amylin(20–29). Tetrahedron Letters, 49(6), pp. 987-991. (doi: 10.1016/j.tetlet.2007.12.021)

Kuil, J., van Wandelen, L.T.M., de Mol, N.J. and Liskamp, R.M.J. (2008) A photoswitchable ITAM peptidomimetic: synthesis and real time surface plasmon resonance (SPR) analysis of the effects of cis–trans isomerization on binding. Bioorganic and Medicinal Chemistry, 16(3), pp. 1393-1399. (doi: 10.1016/j.bmc.2007.10.049)

Liskamp, R. M.J. , Rijkers, D. T.S. and Bakker, S. E. (2008) Bioactive macrocyclic peptides and peptide mimics. In: Diederich, F., Stang, P. J. and Tykwinski, R. R. (eds.) Modern Supramolecular Chemistry: Strategies for Macrocycle Synthesis. Wiley-VCH: Weinheim; Chichester, pp. 1-27. ISBN 9783527318261

Brouwer, A.J., Elgersma, R.C., Jagodzinska, M., Rijkers, D.T.S. and Liskamp, R.M.J. (2008) Delayed fibril formation of amylin(20–29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis. Bioorganic and Medicinal Chemistry Letters, 18(1), pp. 78-84. (doi: 10.1016/j.bmcl.2007.11.009)

Albada, H.B. and Liskamp, R.M.J. (2008) TAC-scaffolded tripeptides as artificial hydrolytic receptors: a combinatorial approach toward esterase mimics. Journal of Combinatorial Chemistry, 10(6), pp. 814-824. (doi: 10.1021/cc800065a)

Arnusch, C.J., Bonvin, A.M.J.J., Verel, A.M., Jansen, W.T.M., Liskamp, R.M.J. , de Kruijff, B., Pieters, R.J. and Breukink, E. (2008) The vancomycin−nisin(1−12)hybrid restores activity against vancomycin resistant enterococci. Biochemistry, 47(48), pp. 12661-12663. (doi: 10.1021/bi801597b)

Branderhorst, H.M., Kooij, R., Salminen, A., Jongeneel, L.H., Arnusch, C.J., Liskamp, R.M.J. , Finne, J. and Pieters, R.J. (2008) Synthesis of multivalent Streptococcus suis adhesion inhibitors by enzymatic cleavage of polygalacturonic acid and ‘click’ conjugation. Organic and Biomolecular Chemistry, 6, pp. 1425-1434. (doi: 10.1039/b800283e)

Dijk, M.V., Nollet, M.L., Weijers, P., Dechesne, A.C., Nostrum, C.F.V., Hennink, W.E., Rijkers, D.T.S. and Liskamp, R.M.J. (2008) Synthesis and characterization of biodegradable peptide-based polymers prepared by microwave-assisted click chemistry. Biomacromolecules, 9(10), pp. 2834-2843. (doi: 10.1021/bm8005984)

University of Utrecht Holding B.V.; Liskamp R M J; Rijkers D T S; Pieters R J (2008) New Multivalent Dendrimer Comprising at Dendrimer Periphery a Number of Active Compounds that are Coupled to the Dendrimer Through 1,2,3-Triazole Or 1,2-Oxazole Heterocyclic Bridge, Useful For Treating, E.G. Cancer. .

Martin, N.I. and Liskamp, R.M.J. (2008) Preparation ofNG-substitutedl-arginine analogues suitable for solid phase peptide synthesis. Journal of Organic Chemistry, 73(19), pp. 7849-7851. (doi: 10.1021/jo801517f)

Pieters, R. and Liskamp, R.M.J. (2008) Multivalent presentation strategies in novel inhibitors of bacterial (toxin) adhesion and synthetic vaccines. Anti-Infective Agents in Medicinal Chemistry, 7(3), pp. 193-200. (doi: 10.2174/187152108784911269)

2007

Pieters, R.J., Rijkers, D.T.S. and Liskamp, R.M.J. (2007) Application of the 1,3-dipolar cycloaddition reaction in chemical biology: approaches toward multivalent carbohydrates and peptides and peptide-based polymers. QSAR & Combinatorial Science, 26(11-12), pp. 1181-1190. (doi: 10.1002/qsar.200740075)

Arnusch, C.J., Branderhorst, H., de Kruijff, B., Liskamp, R.M.J. , Breukink, E. and Pieters, R.J. (2007) Enhanced membrane pore formation by multimeric/oligomeric antimicrobial peptides. Biochemistry, 46(46), pp. 13437-13442. (doi: 10.1021/bi7015553)

Brouwer, A.J., Bunschoten, A. and Liskamp, R.M.J. (2007) Synthesis and evaluation of chloromethyl sulfoxides as a new class of selective irreversible cysteine protease inhibitors. Bioorganic and Medicinal Chemistry Letters, 15(22), pp. 6985-6993. (doi: 10.1016/j.bmc.2007.07.045)

van Zoelen, D.-J., Egmond, M.R., Pieters, R.J. and Liskamp, R.M.J. (2007) Synthesis and evaluation of TAC-based inhibitors of papain as mimics of cystatin B. ChemBioChem, 8(16), pp. 1950-1956. (doi: 10.1002/cbic.200700243)

Elgersma, R.C., Posthuma, G., Rijkers, D.T.S. and Liskamp, R.M.J. (2007) Backbone-modified amylin derivatives: implications for amyloid inhibitor design and as template for self-assembling bionanomaterials. Journal of Peptide Science, 13(11), pp. 709-716. (doi: 10.1002/psc.831)

Hijnen, M., van Zoelen, D.J., Chamorro, C., van Gageldonk, P., Mooi, F.R., Berbers, G. and Liskamp, R.M.J. (2007) A novel strategy to mimic discontinuous protective epitopes using a synthetic scaffold. Vaccine, 25(37-38), pp. 6807-6817. (doi: 10.1016/j.vaccine.2007.06.027)

Ghalit, N., Reichwein, J.F., Hilbers, H.W., Breukink, E., Rijkers, D.T.S. and Liskamp, R.S.J. (2007) Synthesis of bicyclic alkene-/alkane-bridged nisin mimics by ring-closing metathesis and their biochemical evaluation as lipid II binders: toward the design of potential novel antibiotics. ChemBioChem, 8(13), pp. 1540-1554. (doi: 10.1002/cbic.200700244)

Pukin, A.V., Branderhorst, H.M., Sisu, C., Weijers, C.A.G.M., Gilbert, M., Liskamp, R.M.J. , Visser, G.M., Zuilhof, H. and Pieters, R.J. (2007) Strong inhibition of cholera toxin by multivalent GM1 derivatives. ChemBioChem, 8(13), pp. 1500-1503. (doi: 10.1002/cbic.200700266)

Elgersma, R.C., Mulder, G.E., Kruijtzer, J.A.W., Posthuma, G., Rijkers, D.T.S. and Liskamp, R.M.J. (2007) Transformation of the amyloidogenic peptide amylin(20–29) into its corresponding peptoid and retropeptoid: Access to both an amyloid inhibitor and template for self-assembled supramolecular tapes. Bioorganic and Medicinal Chemistry Letters, 17(7), pp. 1837-1842. (doi: 10.1016/j.bmcl.2007.01.042)

Dijkgraaf, I., Liu, S., Kruijtzer, J.A.W., Soede, A.C., Oyen, W.J.G., Liskamp, R.M.J. , Corstens, F.H.M. and Boerman, O.C. (2007) Effects of linker variation on the in vitro and in vivo characteristics of an 111In-labeled RGD peptide. Nuclear Medicine and Biology, 34(1), pp. 29-35. (doi: 10.1016/j.nucmedbio.2006.10.006)

Albada, H.B., Soulimani, F., Weckhuysen, B.M. and Liskamp, R.M.J. (2007) Scaffolded amino acids as a close structural mimic of type-3 copper binding sites. Chemical Communications, 2007(46), pp. 4895-4897. (doi: 10.1039/b709400k)

Branderhorst, H.M., Liskamp, R.M.J. and Pieters, R.J. (2007) Solid-phase carbohydrate synthesis via on-bead protecting group chemistry. Tetrahedron, 63(20), pp. 4290-4296. (doi: 10.1016/j.tet.2007.03.051)

Branderhorst, H.M., Liskamp, R.M.J. , Visser, G.M. and Pieters, R.J. (2007) Strong inhibition of cholera toxin binding by galactose dendrimers. Chemical Communications, 2007(47), pp. 5043-5045. (doi: 10.1039/b711070g)

de Planque, M.R.R., Raussens, V., Contera, S.A., Rijkers, D.T.S., Liskamp, R.J. , Ruysschaert, J.-M., Ryan, J.F., Separovic, F. and Watts, A. (2007) β-sheet structured β-amyloid(1-40) perturbs phosphatidylcholine model membranes. Journal of Molecular Biology, 368(4), pp. 982-997. (doi: 10.1016/j.jmb.2007.02.063)

Dijkgraaf, I., Kruijtzer, J.A.W., Liu, S., Soede, A.C., Oyen, W.J.G., Corstens, F.H.M., Liskamp, R.M.J. and Boerman, O.C. (2007) Improved targeting of the αvβ3 integrin by multimerisation of RGD peptides. European Journal of Nuclear Medicine and Molecular Imaging, 34(2), pp. 267-273. (doi: 10.1007/s00259-006-0180-9)

Dijkgraaf, I., Rijnders, A.Y., Soede, A., Dechesne, A.C., van Esse, G.W., Brouwer, A., Corstens, F.H.M., Boerman, O.C., Rijkers, D.T.S. and Liskamp, R.M.J. (2007) Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes. Organic and Biomolecular Chemistry, 5(6), pp. 935-944. (doi: 10.1039/b615940k)

Ghalit, N., Kemmink, J., Hilbers, H.W., Versluis, C., Rijkers, D.T.S. and Liskamp, R.M.J. (2007) Step-wise and pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis. Organic and Biomolecular Chemistry, 5, pp. 924-934. (doi: 10.1039/b618085j)

Merkx, R., van Haren, M.J., Rijkers, D.T.S. and Liskamp, R.M.J. (2007) Resin-bound sulfonyl azides: efficient loading and activation strategy for the preparation of theN-Acyl sulfonamide linker. Journal of Organic Chemistry, 72(12), pp. 4574-4577. (doi: 10.1021/jo0704513)

van Dijk, M., Mustafa, K., Dechesne, A.C., van Nostrum, C.F., Hennink, W.E., Rijkers, D.T.S. and Liskamp, R.M.J. (2007) Synthesis of peptide-based polymers by microwave-assisted cycloaddition backbone polymerization. Biomacromolecules, 8(2), pp. 327-330. (doi: 10.1021/bm061010g)

2006

Poot, A.J., Ruijter, E., Nuijens, T., Dirksen, E.H.C., Heck, A.J.R., Slijper, M., Rijkers, D.T.S. and Liskamp, R.M.J. (2006) Selective enrichment of ser-/thr-phosphorylated peptides in the presence of ser-/thr-glycosylated peptides. Proteomics, 6(24), pp. 6394-6399. (doi: 10.1002/pmic.200600373)

Dijkgraaf, I., Kruijtzer, J.A.W., Frielink, C., Soede, A.C., Hilbers, H.W., Oyen, W.J.G., Corstens, F.H.M., Liskamp, R.M.J. and Boerman, O.C. (2006) Synthesis and biological evaluation of potent αvβ3-integrin receptor antagonists. Nuclear Medicine and Biology, 33(8), pp. 953-961. (doi: 10.1016/j.nucmedbio.2006.08.008)

van Scherpenzeel, M., van der Pot, M., Arnusch, C.J., Liskamp, R.M.J. and Pieters, R.J. (2006) Detection of galectin-3 by novel peptidic photoprobes. Bioorganic and Medicinal Chemistry Letters, 17(2), pp. 376-378. (doi: 10.1016/j.bmcl.2006.10.043)

Ghalit, N., Rijkers, D.T.S. and Liskamp, R.M.J. (2006) Alkene- and alkyne-bridged mimics of nisin as potential peptide-based antibiotics. Journal of Molecular Catalysis A: Chemical, 254(1-2), pp. 68-77. (doi: 10.1016/j.molcata.2006.03.029)

Elgersma, R.C., Meijneke, T., Posthuma, G., Rijkers, D.T.S. and Liskamp, R.M.J. (2006) Self-Assembly of amylin(20–29) amide-bond derivatives into helical ribbons and peptide nanotubes rather than fibrils. Chemistry: A European Journal, 12(14), pp. 3714-3725. (doi: 10.1002/chem.200501374)

Engel, M.F.M., Yigittop, H., Elgersma, R.C., Rijkers, D.T.S., Liskamp, R.M.J. , de Kruijff, B., Höppener, J.W.M. and Antoinette Killian, J. (2006) Islet amyloid polypeptide inserts into phospholipid monolayers as monomer. Journal of Molecular Biology, 356(3), pp. 783-789. (doi: 10.1016/j.jmb.2005.12.020)

Dijkgraaf, I., Kruijtzer, J.A.W., Frielink, C., Corstens, F.H.M., Oyen, W.J.G., Liskamp, R.M.J. and Boerman, O.C. (2006) αvβ3 integrin-targeting of intraperitoneally growing tumors with a radiolabeled RGD peptide. International Journal of Cancer, 120(3), pp. 605-610. (doi: 10.1002/ijc.22297)

Ballell, L., van Scherpenzeel, M., Buchalova, K., Liskamp, R.M.J. and Pieters, R.J. (2006) A new chemical probe for the detection of the cancer-linked galectin-3. Organic and Biomolecular Chemistry, 4, pp. 4387-4394. (doi: 10.1039/b611050a)

Solvay Pharmaceuticals B.V. (2006) New Protected 4-Nitrophenyl Carbamate Derivative, Useful as Monomers for Preparing Oligourea Peptidomimetics. .

Dirksen, E.H.C., Pinkse, M.W.H., Rijkers, D.T.S., Cloos, J., Liskamp, R.M.J. , Slijper, M. and Heck, A.J.R. (2006) Investigating the dynamic nature of the interactions between nuclear proteins and histones upon DNA damage using an immobilized peptide chemical proteomics approach. Journal of Proteome Research, 5(9), pp. 2380-2388. (doi: 10.1021/pr060278b)

Elgersma, R.C., Meijneke, T., de Jong, R., Brouwer, A.J., Posthuma, G., Rijkers, D.T.S. and Liskamp, R.M.J. (2006) Synthesis and structural investigations of N-alkylated ?-peptidosulfonamide?peptide hybrids of the amyloidogenic amylin(20?29) sequence: implications of supramolecular folding for the design of peptide-based bionanomaterials. Organic and Biomolecular Chemistry, 4, pp. 3587-3597. (doi: 10.1039/b606875h)

Kruijtzer, J. A. W., Kemmink, J. and Liskamp, R. M. J. (2006) A new efficient post-assembly strategy for the synthesis of sulfated peptides. In: 19th American Peptide Symposium, San Diego, CA, USA, 18-23 June 2005, pp. 158-159. (doi: 10.1007/978-0-387-26575-9_63)

Liskamp, R.M.J. , Brouwer, A.J., Merkx, R., Dabrowska, K. and Rijkers, D.T. (2006) Synthesis and applications of β-aminoethanesulfonyl azides. Synthesis, 3, pp. 455-460. (doi: 10.1055/s-2006-926273)

Merkx, R., Rijkers, D. T. S., Brouwer, A. J., Kemmink, J. and Liskamp, R. M. J. (2006) Peptide-derived (sulfonyl)Azides as versatile synthons in chemoselective bioconjugations. In: 19th American Peptide Symposium, San Diego, CA, USA, 18-23 June 2005, pp. 198-199. (doi: 10.1007/978-0-387-26575-9_83)

Rijkers, D. T. S., ten Brink, H. T., Ghalit, N., Tois, J. and Liskamp, R. M. J. (2006) Synthesis of cyclic peptides via transition metal catalyzed C-C bond formation. In: 19th American Peptide Symposium, San Diego, CA, USA, 18-23 June 2005, pp. 50-52. (doi: 10.1007/978-0-387-26575-9_11)

Rijkers, D. T. S., van Esse, G. W., Merkx, R., Brouwer, A. J., Jacobs, H. J. F., Pieters, R. J. and Liskamp, R. M. J. (2006) Microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (‘click’) chemistry. In: 19th American Peptide Symposium, San Diego, CA, USA, 18-23 June 2005, pp. 152-153. (doi: 10.1007/978-0-387-26575-9_60)

ten Brink, H.T., Rijkers, D.T.S. and Liskamp, R.M.J. (2006) Synthesis of alkyne-bridged cyclic tripeptides toward constrained mimics of vancomycin. Journal of Organic Chemistry, 71(5), pp. 1817-1824. (doi: 10.1021/jo051933m)

van Zoelen, D.-J., Egmond, M. R., Pieters, R. J. and Liskamp, R. M. J. (2006) Interference with protein-protein interactions involved in protease inhibitor complex formation. In: 19th American Peptide Symposium, San Diego, CA, USA, 18-23 June 2005, pp. 212-213. (doi: 10.1007/978-0-387-26575-9_90)

2005

de Mol, N.J., Catalina, M.I., Dekker, F.J., Fischer, M.J.E., Heck, A.J.R. and Liskamp, R.M.J. (2005) Protein flexibility and ligand rigidity: a thermodynamic and kinetic study of ITAM-based ligand binding to Syk tandem SH2. ChemBioChem, 6(12), pp. 2261-2270. (doi: 10.1002/cbic.200500141)

van der Veken, P., Dirksen, E.H.C., Ruijter, E., Elgersma, R.C., Heck, A.J.R., Rijkers, D.T.S., Slijper, M. and Liskamp, R.M.J. (2005) Development of a novel chemical probe for the selective enrichment of phosphorylated serine- and threonine-containing peptides. ChemBioChem, 6(12), pp. 2271-2280. (doi: 10.1002/cbic.200500209)

Haas, P.-J. et al. (2005) The structure of the C5a receptor-blocking domain of chemotaxis inhibitory protein of staphylococcus aureus is related to a group of immune evasive molecules. Journal of Molecular Biology, 353(4), pp. 859-872. (doi: 10.1016/j.jmb.2005.09.014)

Autar, R., Liskamp, R.M.J. and Pieters, R. (2005) A facile synthesis of the GalNAcβ1→4Gal target sequence of respiratory pathogens. Carbohydrate Research, 340(15), pp. 2436-2442. (doi: 10.1016/j.carres.2005.08.001)

Joosten, J.A.F., Tholen, N.T.H., Ait El Maate, F., Brouwer, A.J., van Esse, G.W., Rijkers, D.T.S., Liskamp, R.M.J. and Pieters, R.J. (2005) High-yielding microwave-assisted synthesis of triazole-linked glycodendrimers by copper-catalyzed [3+2] cycloaddition. European Journal of Organic Chemistry, 2005(15), pp. 3182-3185. (doi: 10.1002/ejoc.200500216)

Catalina, M.I., Fischer, M.J.E., Dekker, F.J., Liskamp, R.M.J. and Heck, A.J.R. (2005) Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study. Journal of the American Society for Mass Spectrometry, 16(7), pp. 1039-1051. (doi: 10.1016/j.jasms.2005.02.011)

Wels, B., Kruijtzer, J.A.W., Garner, K., Nijenhuis, W.A.J., Gispen, W.H., Adan, R.A.H. and Liskamp, R.M.J. (2005) Synthesis of a novel potent cyclic peptide MC4-ligand by ring-closing metathesis. Bioorganic and Medicinal Chemistry, 13(13), pp. 4221-4227. (doi: 10.1016/j.bmc.2005.04.027)

Rijkers, D.T.S., Kruijtzer, J.A.W., Killian, J.A. and Liskamp, R.M.J. (2005) A convenient solid phase synthesis of S-palmitoyl transmembrane peptides. Tetrahedron Letters, 46(19), pp. 3341-3345. (doi: 10.1016/j.tetlet.2005.03.079)

Brouwer, A.J. and Liskamp, R.M.J. (2005) Synthesis of novel dendrimeric systems containing NLO ligands. European Journal of Organic Chemistry, 2005(3), pp. 487-495. (doi: 10.1002/ejoc.200400609)

de Haan, E.C., Moret, E.D., Wagenaar-Hilbers, J.P.A., Liskamp, R.M.J. and Wauben, M.H.M. (2005) Possibilities and limitations in the rational design of modified peptides for T cell mediated immunotherapy. Molecular Immunology, 42(3), pp. 365-373. (doi: 10.1016/j.molimm.2004.07.015)

de Haan, E.C., Wagenaar-Hilbers, J.P.A., Liskamp, R.M.J. , Moret, E.D. and Wauben, M.H.M. (2005) Limited plasticity in T cell recognition of modified T cell receptor contact residues in MHC class II bound peptides. Molecular Immunology, 42(3), pp. 355-364. (doi: 10.1016/j.molimm.2004.07.044)

Kasyanov, V. et al. (2005) Tannic acid mimicking dendrimers as small intestine submucosa stabilizing nanomordants. Biomaterials, 27(5), pp. 745-751. (doi: 10.1016/j.biomaterials.2005.06.022)

Appeldoorn, C.C.M., Joosten, J.A.F., Ait el Maate, F., Dobrindt, U., Hacker, J., Liskamp, R.M.J. , Khan, A.S. and Pieters, R.J. (2005) Novel multivalent mannose compounds and their inhibition of the adhesion of type 1 fimbriated uropathogenic E. coli. Tetrahedron: Asymmetry, 16(2), pp. 361-372. (doi: 10.1016/j.tetasy.2004.11.014)

Wels, B., Kruijtzer, J.A.W., Garner, K.M., Adan, R.A.H. and Liskamp, R.M.J. (2005) Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups. Bioorganic and Medicinal Chemistry Letters, 15(2), pp. 287-290. (doi: 10.1016/j.bmcl.2004.10.082)

van Leeuwen, S.H., Quaedflieg, P.J.L.M., Broxterman, Q.B., Milhajlovic, Y. and Liskamp, R.M.J. (2005) The synthesis of amides and dipeptides from unprotected amino acids by a simultaneous protection–activation strategy using boron trifluoride diethyl etherate. Tetrahedron Letters, 46(4), pp. 653-656. (doi: 10.1016/j.tetlet.2004.11.129)

Broekema, M., van Eerd, J.J.E.M., Oyen, W.J.G., Corstens, F.H.M., Liskamp, R.M.J. , Boerman, O.C. and Harris, T.D. (2005) Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci. Journal of Medicinal Chemistry, 48(20), pp. 6442-6453. (doi: 10.1021/jm050383h)

de Mol, N.J., Dekker, F.J., Broutin, I., Fischer, M.J.E. and Liskamp, R.M.J. (2005) Surface plasmon resonance thermodynamic and kinetic analysis as a strategic tool in drug design. Distinct ways for phosphopeptides to plug into Src- and Grb2 SH2 domains. Journal of Medicinal Chemistry, 48(3), pp. 753-763. (doi: 10.1021/jm049359e)

Ghalit, N.,, Rijkers, D.T.S., Kemmink, J., Versluis, C. and Liskamp, R.M.J. (2005) Pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis. Chemical Communications(2), pp. 192-194. (doi: 10.1039/b415555f)

Ghalit, N., Poot, A.J., Fürstner, A., Rijkers, D.T.S. and Liskamp, R.M.J. (2005) Ring-closing alkyne metathesis approach toward the synthesis of alkyne mimics of thioether A-, B-, C-, and DE-ring systems of the lantibiotic nisin Z. Organic Letters, 7(14), pp. 2961-2964. (doi: 10.1021/ol0508781)

Kruijtzer, J.A.W., Nijenhuis, W.A.J., Wanders, N., Gispen, W.H., Liskamp, R.M.J. and Adan, R.A.H. (2005) Peptoid−peptide hybrids as potent novel melanocortin receptor ligands. Journal of Medicinal Chemistry, 48(13), pp. 4224-4230. (doi: 10.1021/jm0490033)

Merkx, R., Brouwer, A.J., Rijkers, D.T.S. and Liskamp, R.M.J. (2005) Highly efficient coupling of β-substituted aminoethane sulfonyl azides with thio acids, toward a new chemical ligation reaction. Organic Letters, 7(6), pp. 1125-1128. (doi: 10.1021/ol0501119)

Özdirekcan, S., Rijkers, D.T.S., Liskamp, R.M.J. and Killian, J.A. (2005) Influence of flanking residues on tilt and rotation angles of transmembrane peptides in lipid bilayers. A solid-state2H NMR study. Biochemistry, 44(3), pp. 1004-1012. (doi: 10.1021/bi0481242)

Rijkers, D.T.S., van Esse, G.W., Merkx, R., Brouwer, A.J., Jacobs, H.J.F., Pieters, R.J. and Liskamp, R.M.J. (2005) Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry. Chemical Communications(36), pp. 4581-4583. (doi: 10.1039/b507975f)

van Meer, G. and Liskamp, R.M.J. (2005) Brilliant lipids. Nature Methods, 2(1), pp. 14-15. (doi: 10.1038/nmeth0105-14)

2004

Chamorro, C. and Liskamp, R.M.J. (2004) Selection of synthetic receptors capable of sensing the difference in binding of d-Ala-d-Ala or d-Ala-d-Lac ligands by screening of a combinatorial CTV-based library. Tetrahedron, 60(49), pp. 11145-11157. (doi: 10.1016/j.tet.2004.08.074)

Haas, P.-J., de Haas, C.J.C., Kleibeuker, W., Poppelier, M.J.J.G., van Kessel, K.P.M., Kruijtzer, J.A.W., Liskamp, R.M.J. and van Strijp, J.A.G. (2004) N-terminal residues of the chemotaxis inhibitory protein of Staphylococcus aureus are essential for blocking formylated peptide receptor but not C5a receptor. Journal of Immunology, 173(9), pp. 5704-11.

de Planque, M.R.R., Rijkers, D.T.S., Fletcher, J.I., Liskamp, R.M.J. and Separovic, F. (2004) The αM1 segment of the nicotinic acetylcholine receptor exhibits conformational flexibility in a membrane environment. Biochimica et Biophysica Acta: Biomembranes, 1665(1-2), pp. 40-47. (doi: 10.1016/j.bbamem.2004.06.021)

Rijkers, D.T.S., den Hartog, J.A.J. and Liskamp, R.M.J. (2004) Synthesis and biological activity of N-terminal lipidated and/or fluorescently labeled conjugates of astressin as corticotropin releasing factor antagonists. Bioorganic and Medicinal Chemistry, 12(19), pp. 5099-5106. (doi: 10.1016/j.bmc.2004.07.035)

Monnee, M.C.F., Brouwer, A.J. and Liskamp, R.M.J. (2004) Synthesis, screening and evaluation of a combined library of tweezer- and tripodal synthetic receptors. QSAR & Combinatorial Science, 23(7), pp. 546-559. (doi: 10.1002/qsar.200420019)

Wang, X., Permentier, H.P., Rink, R., Kruijtzer, J.A.W., Liskamp, R.M.J. , Wösten, H.A.B., Poolman, B. and Robillard, G.T. (2004) Probing the self-assembly and the accompanying structural changes of hydrophobin SC3 on a hydrophobic surface by mass spectrometry. Biophysical Journal, 87(3), pp. 1919-1928. (doi: 10.1529/biophysj.104.041616)

Nijenhuis, W.A.J., Wanders, N., Kruijtzer, J.A.W., Liskamp, R.M. , Gispen, W.H. and Adan, R.A.H. (2004) Accelerating sensory recovery after sciatic nerve crush: non-selective versus melanocortin MC4 receptor-selective peptides. European Journal of Pharmacology, 495(2-3), pp. 145-152. (doi: 10.1016/j.ejphar.2004.05.037)

Liskamp, R.M.J. and Kruijtzer, J.A.W. (2004) Peptide transformation leading to peptide-peptidosulfonamide hybrids and oligo peptidosulfonamides. Molecular Diversity, 8(2), pp. 79-87. (doi: 10.1023/B:MODI.0000025651.88080.9d)

Strandberg, E., Özdirekcan, S., Rijkers, D.T.S., van der Wel, P.C.A., Koeppe, R.E., Liskamp, R.M.J. and Antoinette Killian, J. (2004) Tilt angles of transmembrane model peptides in oriented and non-oriented lipid bilayers as determined by 2H solid-state NMR. Biophysical Journal, 86(6), pp. 3709-3721. (doi: 10.1529/biophysj.103.035402)

Rijkers, D.T.S., Kruijtzer, J.A.W., van Oostenbrugge, M., Ronken, E., den Hartog, J.A.J. and Liskamp, R.M.J. (2004) Structure-activity studies on the corticotropin releasing factor antagonist astressin, leading to a minimal sequence necessary for antagonistic activity. ChemBioChem, 5(3), pp. 340-348. (doi: 10.1002/cbic.200300769)

de Planque, M.R.R., Rijkers, D.T.S., Liskamp, R.M.J. and Separovic, F. (2004) TheαM1 transmembrane segment of the nicotinic acetylcholine receptor interacts strongly with model membranes. Magnetic Resonance in Chemistry, 42(2), pp. 148-154. (doi: 10.1002/mrc.1326)

Arosio, D., Vrasidas, I., Valentini, P., Liskamp, R.M.J. , Pieters, R.J. and Bernardi, A. (2004) Synthesis and cholera toxin binding properties of multivalent GM1 mimicsElectronic supplementary information (ESI) available: characterization of the polyvalent compounds ? imide by-products. See http://www.rsc.org/suppdata/ob/b4/b405344c/. Organic and Biomolecular Chemistry, 2(14), p. 2113. (doi: 10.1039/b405344c)

Ballell, L., Alink, K.J., Slijper, M., Versluis, C., Liskamp, R.M.J. and Pieters, R.J. (2004) A new chemical probe for proteomics of carbohydrate-binding proteins. ChemBioChem, 6(2), pp. 291-295. (doi: 10.1002/cbic.200400209)

Ballell, L., Joosten, J.A.F., Maate, F.A.e., Liskamp, R.M.J. and Pieters, R.J. (2004) Microwave-assisted, tin-mediated, regioselective 3-O-alkylation of galactosides. Tetrahedron Letters, 45(35), pp. 6685-6687. (doi: 10.1016/j.tetlet.2004.06.113)

Chamorro, C., Hofman, J.-W. and Liskamp, R.M.J. (2004) Combinatorial solid-phase synthesis and screening of a diverse tripodal triazacyclophane (TAC)-based synthetic receptor library showing a remarkable selectivity towards a d-Ala-d-Ala containing ligand. Tetrahedron, 60(39), pp. 8691-8697. (doi: 10.1016/j.tet.2004.05.121)

Dehaan, E., Wauben, M., Wagenaarhilbers, J., Grosfeldstulemeyer, M., Rijkers, D., Moret, E. and Liskamp, R.M.J. (2004) Stabilization of peptide guinea pig myelin basic protein 72-85 by N-terminal acetylation - implications for immunological studies. Molecular Immunology, 40(13), pp. 943-948. (doi: 10.1016/j.molimm.2003.10.015)

Dekker, F. J., de Mol, N. J., Fischer, M. J.E. and Liskamp, R. M.J. (2004) Interference with protein-protein interactions in signal transduction. In: Chorev, M. and Sawyer, T. K. (eds.) Peptide Revolution. American Peptide Society, pp. 546-547. ISBN 9781402028168

Joosten, J.A.F., Loimaranta, V., Appeldoorn, C.C.M., Haataja, S., El Maate, F.., Liskamp, R.M.J. , Finne, J. and Pieters, R.J. (2004) Inhibition of Streptococcus suis adhesion by dendritic galabiose compounds at low nanomolar concentration. Journal of Medicinal Chemistry, 47(26), pp. 6499-6508. (doi: 10.1021/jm049476+)

Kruijtzer, J. A.W., Nijenhuis, W. A.J., Gispen, W. H., Adan, R. A.H. and Liskamp, R. M.J. (2004) Peptoid-peptide hybrids as potent novel melanocortin receptor ligands. In: Chorev, M. and Sawyer, T. K. (eds.) Peptide Revolution. American Peptide Society, pp. 213-214. ISBN 9781402028168

Liskamp, R.M.J. , Moree, W. J., De Bont, D. B. A., Löwik, D. W. P. M., Brouwer, A. J., Monnee, M. C. F., De Jong, R. and Rijkers, D. T.S. (2004) The sulfonamide moiety in peptidomimetics and peptidomimetic-peptide hybrids. In: Chorev, M. and Sawyer, T. K. (eds.) Peptide Revolution. American Peptide Society, pp. 210-212. ISBN 9781402028168

Ridder, A.N.J.A., Spelbrink, R.E.J., Demmers, J.A.A., Rijkers, D.T.S., Liskamp, R.M.J. , Brunner, J., Heck, A.J.R., de Kruijff, B. and Killian, J.A. (2004) Photo-crosslinking analysis of preferential interactions between a transmembrane peptide and matching lipids. Biochemistry, 43(15), pp. 4482-4489. (doi: 10.1021/bi049899d)

Rijkers, D. T.S., Höppener, J. W.M., Posthuma, G., Lips, C. J.M. and Liskamp, R. M.J. (2004) Inhibition of amyloid formation of human amylin. In: Chorev, M. and Sawyer, T. K. (eds.) Peptide Revolution. American Peptide Society, pp. 773-774. ISBN 9781402028168

ten Brink, H.T., Rijkers, D.T.S., Kemmink, J., Hilbers, H.W. and Liskamp, R.M.J. (2004) Ring-closing metathesis for the synthesis of side chain knotted pentapeptides inspired by vancomycin. Organic and Biomolecular Chemistry, 2(18), pp. 2658-2663. (doi: 10.1039/b408820d)

Ver Donck, K., Bols, L., Bongaarts, R., Van Osta, P., Brouwer, A.J., Liskamp, R.M.J. , Perrault, D., Kalutkiewicz, K., Geysen, J. and Pulak, R. (2004) New technology automates sorting of large, bead-based combichem libraries. In: Chorev, M. and Sawyer, T. K. (eds.) Peptide Revolution. American Peptide Society, pp. 147-148. ISBN 9781402028168

2003

Autar, R., Khan, A.S., Schad, M., Hacker, J., Liskamp, R.M.J. and Pieters, R.J. (2003) Adhesion inhibition of F1C-fimbriated escherichia coli and pseudomonas aeruginosa PAK and PAO by multivalent carbohydrate ligands. ChemBioChem, 4(12), pp. 1317-1325. (doi: 10.1002/cbic.200300719)

Catalina, M.I., Dekker, F.J., Liskamp, R.M.J. , Versluis, C., Maier, C.S. and Heck, A.J.R. (2003) Structural analysis of high affinity divalent phosphopeptide hybrids of spleen tyrosine kinase. International Journal of Mass Spectrometry, 228(2-3), pp. 879-890. (doi: 10.1016/S1387-3806(03)00190-8)

Dekker, F.J., de Mol, N.J., Fischer, M.J.E. and Liskamp, R.M.J. (2003) Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the syk SH2 domains with equally high affinity as the natural ligand. Bioorganic and Medicinal Chemistry Letters, 13(7), pp. 1241-1244. (doi: 10.1016/S0960-894X(03)00117-3)

Dekker, F.J., de Mol, N.J., Bultinck, P., Kemmink, J., Hilbers, H.W. and Liskamp, R.M.J. (2003) Role of solution conformation and flexibility of short peptide ligands that bind to the p56^lck SH2 domain. Bioorganic and Medicinal Chemistry, 11(6), pp. 941-949. (doi: 10.1016/S0968-0896(02)00536-9)

Nijenhuis, W.A.J., Kruijtzer, J.A.W., Wanders, N., Vrinten, D.H., Garner, K.M., Schaaper, W.M.M., Meloen, R.H., Gispen, W.H., Liskamp, R.M.J. and Adan, R.A.H. (2003) Discovery and in vivo evaluation of new melanocortin-4 receptor-selective peptides. Peptides, 24(2), pp. 271-280. (doi: 10.1016/S0196-9781(03)00032-9)

Ameijde, J. v. and Liskamp, R.M.J. (2003) Synthesis of novel trivalent amino acid glycoconjugates based on the cyclotriveratrylene ('CTV') scaffold. Organic and Biomolecular Chemistry, 1(15), pp. 2661-2669. (doi: 10.1039/b303795a)

Chamorro, C. and Liskamp, R.M.J. (2003) Approaches to the solid phase of a cyclotriveratrylene scaffold-based tripodal library as potential artificial receptors. Journal of Combinatorial Chemistry, 5(6), pp. 794-801. (doi: 10.1021/cc034003u)

Dekker, F.J., de Mol, N.J., Fischer, M.J.E., Kemmink, J. and Liskamp, R.M.J. (2003) Cyclic phosphopeptides for interference with Grb2 SH2 domain signal transduction prepared by ring-closing metathesis and phosphorylation. Organic and Biomolecular Chemistry, 1(19), pp. 3297-3303. (doi: 10.1039/b306681a)

Merkx, R., Rijkers, D.T.S., Kemmink, J. and Liskamp, R.M.J. (2003) Chemoselective coupling of peptide fragments using the Staudinger ligation. Tetrahedron Letters, 44(24), pp. 4515-4518. (doi: 10.1016/S0040-4039(03)01014-1)

Vrasidas, I., André, S., Valentini, P., Böck, C., Lensch, M., Kaltner, H., Liskamp, R.M.J. , Gabius, H.-J. and Pieters, R.J. (2003) Rigidified multivalent lactose molecules and their interactions with mammalian galectins: a route to selective inhibitors. Organic and Biomolecular Chemistry, 1(5), pp. 803-810. (doi: 10.1039/b210923a)

2002

van Leeuwen, S.H., Quaedflieg, P.J.L.M., Broxterman, Q.B. and Liskamp, R.M.J. (2002) Synthesis of amides from unprotected amino acids by a simultaneous protection–activation strategy using dichlorodialkyl silanes. Tetrahedron Letters, 43(50), pp. 9203-9207. (doi: 10.1016/S0040-4039(02)02275-X)

de Jong, R., Rijkers, D.T.S. and Liskamp, R.M.J. (2002) Automated solid-phase synthesis and structural investigation of -peptidosulfonamides and -peptidosulfonamide/-peptide hybrids: -peptidosulfonamide and -peptide foldamers are two of a different kind. Helvetica Chimica Acta, 85(12), pp. 4230-4243. (doi: 10.1002/hlca.200290008)

Rump, E.T., Rijkers, D.T.S., Hilbers, H.W., de Groot, P.G. and Liskamp, R.M.J. (2002) Cyclotriveratrylene (CTV) as a new chiral triacid scaffold capable of inducing triple helix formation of collagen peptides containing either a native sequence or pro-hyp-gly repeats. Chemistry: A European Journal, 8(20), pp. 4613-4621. (doi: 10.1002/1521-3765(20021018)8:20<4613::AID-CHEM4613>3.0.CO;2-R)

Rijkers, D.T.S., Höppener, J.W.M., Posthuma, G., Lips, C.J.M. and Liskamp, R.M.J. (2002) Inhibition of amyloid fibril formation of human amylin by N-alkylated amino acid and -hydroxy acid residue containing peptides. Chemistry: A European Journal, 8(18), pp. 4285-4291. (doi: 10.1002/1521-3765(20020916)8:18<4285::AID-CHEM4285>3.0.CO;2-0)

Halkes, S.B.A., Vrasidas, I., Rooijer, G.R., van den Berg, A.J.J., Liskamp, R.M.J. and Pieters, R. (2002) Synthesis and biological activity of polygalloyl-dendrimers as stable tannic acid mimics. Bioorganic and Medicinal Chemistry Letters, 12(12), pp. 1567-1570. (doi: 10.1016/S0960-894X(02)00245-7)

Rijkers, D.T.S., van Vugt, H.H.R., Jacobs, H.J.F. and Liskamp, R.M.J. (2002) A convenient synthesis of azido peptides by post-assembly diazo transfer on the solid phase applicable to large peptides. Tetrahedron Letters, 43(20), pp. 3657-3660. (doi: 10.1016/S0040-4039(02)00629-9)

Dekker, F.J., de Mol, N.J., van Ameijde, J., Fischer, M.J.E., Ruijtenbeek, R., Redegeld, F.A.M. and Liskamp, R.M.J. (2002) Replacement of the intervening amino acid sequence of a Syk-binding diphosphopeptide by a nonpeptide spacer with preservation of high affinity. ChemBioChem, 3(2-3), pp. 238-242. (doi: 10.1002/1439-7633(20020301)3:2/3<238::AID-CBIC238>3.0.CO;2-W)

Rijkers, D.T.S., den Hartog, J.A.J. and Liskamp, R.M.J. (2002) An optimized solid phase synthesis strategy- including on-resin lactamization?of astressin, its retro-, inverso-, and retro-inverso isomers as corticotropin releasing factor antagonists. Biopolymers, 63(2), pp. 141-149. (doi: 10.1002/bip.10052)

Ruijtenbeek, R., Versluis, C., Heck, A.J.R., Redegeld, F.A.M., Nijkamp, F.P. and Liskamp, R.M.J. (2002) Characterization of a phosphorylated peptide and peptoid and peptoid-peptide hybrids by mass spectrometry. Journal of Mass Spectrometry, 37(1), pp. 47-55. (doi: 10.1002/jms.245)

Branderhorst, H.M., Kemmink, J., Liskamp, R.M.J. and Pieters, R.J. (2002) Catalytic conversions of diazosugars. Tetrahedron Letters, 43(52), pp. 9601-9603. (doi: 10.1016/S0040-4039(02)02407-3)

Opatz, T. and Liskamp, R.M.J. (2002) Synthesis and screening of libraries of synthetic tripodal receptor molecules with three different amino acid or peptide arms: identification of iron binders. ACS Combinatorial Science, 4(4), pp. 275-284. (doi: 10.1021/cc020009s)

Strandberg, E., Morein, S., Rijkers, D.T.S., Liskamp, R.M.J. , van der Wel, P.C.A. and Killian, J.A. (2002) Lipid dependence of membrane anchoring properties and snorkeling behavior of aromatic and charged residues in transmembrane peptides. Biochemistry, 41(23), pp. 7190-7198. (doi: 10.1021/bi012047i)

Vrasidas, I., Kemmink, J., Liskamp, R.M.J. and Pieters, R. J. (2002) Synthesis and cholera toxin binding properties of a lactose-2-aminothiazoline conjugate. Organic Letters, 4(10), pp. 1807-1808. (doi: 10.1021/ol025909w)

Wels, B., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2002) Synthesis of cyclic (α2β)-tripeptides as potential peptide turn mimetics. Organic Letters, 4(13), pp. 2173-2176. (doi: 10.1021/ol025988b)

2001

Monnee, M.C.F., Brouwer, A.J., Verbeek, L.M., van Wageningen, A.M.A. and Liskamp, R.M.J. (2001) Bio-inspired synthetic receptor molecules towards mimicry of vancomycin. Bioorganic and Medicinal Chemistry Letters, 11(12), pp. 1521-1525. (doi: 10.1016/S0960-894X(01)00237-2)

Ruijtenbeek, R., Kruijtzer, J.A., van de Wiel, W., Fischer, M.J., Flück, M., Redegeld, F.A., Liskamp, R.M.J. and Nijkamp, F.P. (2001) Peptoid - peptide hybrids that bind Syk SH2 domains involved in signal transduction. ChemBioChem, 2(3), pp. 171-9. (doi: 10.1002/1439-7633(20010302)2:3<171::AID-CBIC171>3.0.CO;2-B)

Monnee, M.C.F., Marijne, M.F., Brouwer, A.J. and Liskamp, R.M.J. (2001) Erratum to "A practical solid phase synthesis of oligopeptidosulfonamide foldamers"[Tetrahedron Letters 41 (2000) 7991–7995]. Tetrahedron Letters, 42(5), p. 965. (doi: 10.1016/S0040-4039(00)02112-2)

Quadrant Healthcare UK Ltd. (2001) New Peptoid Useful in Therapy Comprises a Specific Amino Acid Sequence. .

Boeijen, A., van Ameijde, J. and Liskamp, R.M.J. (2001) Solid-phase synthesis of oligourea peptidomimetics employing the Fmoc protection strategy. Journal of Organic Chemistry, 66(25), pp. 8454-8462. (doi: 10.1021/jo010656q)

de Planque, M.R.R., Goormaghtigh, E., Greathouse, D.V., Koeppe, R.E., Kruijtzer, J.A.W., Liskamp, R.M.J. , de Kruijff, B. and Killian, J.A. (2001) Sensitivity of single membrane-spanning α-helical peptides to hydrophobic mismatch with a lipid bilayer: effects on backbone structure, orientation, and extent of membrane incorporation. Biochemistry, 40(16), pp. 5000-5010. (doi: 10.1021/bi000804r)

Opatz, T. and Liskamp, R.M.J. (2001) A electively deprotectable triazacyclophane scaffold for the construction of artificial receptors. Organic Letters, 3(22), pp. 3499-3502. (doi: 10.1021/ol0101741)

Solvay Pharmaceuticals B.V.; Duphar International Research B.V. (2001) New Corticotrophin Releasing Factor Peptide Antagonists. .

2000

Reichwein, J.F., Versluis, C. and Liskamp, R.M.J. (2000) Synthesis of cyclic peptides by ring-closing metathesis. Journal of Organic Chemistry, 65(19), pp. 6187-6195. (doi: 10.1021/jo000759t)

Brouwer, A.J., van der Linden, H.J. and Liskamp, R.M.J. (2000) Combinatorial chemistry for ligand development in catalysis: synthesis and catalysis screening of peptidosulfonamide tweezers on the solid phase. Journal of Organic Chemistry, 65(6), pp. 1750-1757. (doi: 10.1021/jo991628z)

van Ameijde, J. and Liskamp, R.M.J. (2000) Peptidomimetic building blocks for the synthesis of sulfonamide peptoids. Tetrahedron Letters, 41(7), pp. 1103-1106. (doi: 10.1016/S0040-4039(99)02240-6)

DSM NV (2000) Production of L-Aspartyl-D-Alanine 3-Thietanyl-Amide Di:Peptide Sweeteners. .

1999

van Wageningen, A.M.A. and Liskamp, R.M.J. (1999) Solution phase combinatorial chemistry using cyclotriveratrylene-based tripodal scaffolds. Tetrahedron Letters, 40(52), pp. 9347-9351. (doi: 10.1016/S0040-4039(99)01979-6)

Reichwein, J.F., Wels, B., Kruijtzer, J.A.W., Versluis, C. and Liskamp, R.M.J. (1999) Rolling loop scan: an approach featuring ring-closing metathesis for generating libraries of peptides with molecular shapes mimicking bioactive conformations or local folding of peptides and proteins. Angewandte Chemie (International Edition), 38(24), pp. 3684-3687. (doi: 10.1002/(SICI)1521-3773(19991216)38:24<3684::AID-ANIE3684>3.0.CO;2-M)

de Bont, D.B.A., Sliedregt-Bol, K.M., Hofmeyer, L.J.F. and Liskamp, R.M.J. (1999) Increased stability of peptidesulfonamide peptidomimetics towards protease catalyzed degradation. Bioorganic and Medicinal Chemistry Letters, 7(6), pp. 1043-1047. (doi: 10.1016/S0968-0896(99)00021-8)

Gossage, R.A., Jastrzebski, J.T.B.H., van Ameijde, J., Mulders, S.J.E., Brouwer, A.J., Liskamp, R.M.J. and van Koten, G. (1999) Synthesis and catalytic application of amino acid based dendritic macromolecules. Tetrahedron Letters, 40(7), pp. 1413-1416. (doi: 10.1016/S0040-4039(98)02622-7)

van Dijk-Wolthuis, W.N.E., van de Wetering, P., Hinrichs, W.L.J., Hofmeyer, L.J.F., Liskamp, R.M.J. , Crommelin, D.J.A. and Hennink, W.E. (1999) A versatile method for the conjugation of proteins and peptides to poly[2-(dimethylamino)ethyl methacrylate]. Bioconjugate Chemistry, 10(4), pp. 687-692. (doi: 10.1021/bc980126+)

1998

Boeijen, A., Kruijtzer, J.A.W. and Liskamp, R.M.J. (1998) Combinatorial chemistry of hydantoins. Bioorganic and Medicinal Chemistry Letters, 8(17), pp. 2375-2380. (doi: 10.1016/S0960-894X(98)00429-6)

Kruijtzer, J.A.W., Hofmeyer, L.J.F., Heerma, W., Versluis, C. and Liskamp, R.M.J. (1998) Solid-phase syntheses of peptoids using Fmoc-ProtectedN-substituted glycines: the synthesis of (retro)peptoids of leu-enkephalin and substance P. Chemistry: A European Journal, 4(8), pp. 1570-1580. (doi: 10.1002/(SICI)1521-3765(19980807)4:8<1570::AID-CHEM1570>3.0.CO;2-2)

Boeijen, A. and Liskamp, R.M.J. (1998) Sequencing of peptoid peptidomimetics by Edman degradation. Tetrahedron Letters, 39(21), pp. 3589-3592. (doi: 10.1016/S0040-4039(98)00556-5)

Reichwein, J.F. and Liskamp, R.M.J. (1998) Site-specific N-alkylation of peptides on the solid phase. Tetrahedron Letters, 39(10), pp. 1243-1246. (doi: 10.1016/S0040-4039(97)10766-3)

Liskamp, R. M. J. (1998) A new application of modified peptides and peptidomimetics: potential anticancer agents. In: Mulzer, J. and Waldmann, H. (eds.) Organic Synthesis Highlights III. Wiley-VCH: Weinheim, pp. 366-373. ISBN 9783527619962 (doi: 10.1002/9783527619962.ch53)

Liskamp, R. M. J. (1998) Opportunities for new chemical libraries: unnatural biopolymers and diversomers. In: Mulzer, J. and Waldmann, H. (eds.) Organic Synthesis Highlights III. Wiley-VCH: Weinheim, pp. 245-249. ISBN 9783527619962 (doi: 10.1002/9783527619962.ch39)

1997

Heerma, W., Boon, J.-P.J.L., Versluis, C., Kruijtzer, J.A.W., Hofmeyer, L.J.F. and Liskamp, R.M.J. (1997) Comparing mass spectrometric characteristics of peptides and peptoids—2†. Journal of Mass Spectrometry, 32(7), pp. 697-704. (doi: 10.1002/(SICI)1096-9888(199707)32:7<697::AID-JMS521>3.0.CO;2-U)

Mulders, S.J.E., Brouwer, A.J. and Liskamp, R.M.J. (1997) Molecular diversity of novel amino acid based dendrimers. Tetrahedron Letters, 38(17), pp. 3085-3088. (doi: 10.1016/S0040-4039(97)00551-0)

Grommé, M., van der Valk, R., Sliedregt, K., Vernie, L., Liskamp, R. , Hämmerling, G., Koopmann, J.-O., Momburg, F. and Neefjes, J. (1997) The rational design of TAP inhibitors using peptide substrate modifications and peptidomimetics. European Journal of Immunology, 27(4), pp. 898-904. (doi: 10.1002/eji.1830270415)

O'Connell, M.A., Kelleher, D., Liskamp, R.M.J. , Hall, N., O'Neill, L.A.J. and Long, A. (1997) Tnf-mediated cytotoxicity of l929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase c isozymes. Cytokine, 9(2), pp. 83-92. (doi: 10.1006/cyto.1996.0140)

Mulders, S.J.E., Brouwer, A.J., van der Meer, P.G.J. and Liskamp, R.M.J. (1997) Synthesis of a novel amino acid based dendrimer. Tetrahedron Letters, 38(4), pp. 631-634. (doi: 10.1016/S0040-4039(96)02358-1)

Kruijtzer, J.A.W., Lefeber, D.J. and Liskamp, R.M.J. (1997) Approaches to the synthesis of ureapeptoid peptidomimetics. Tetrahedron Letters, 38(30), pp. 5335-5338. (doi: 10.1016/S0040-4039(97)01166-0)

Liskamp, R.M.J. (1997) Combinatorial chemistry: a basic necessity inspired by nature's own approaches. Pharmacochemistry Library, 28, pp. 291-306. (doi: 10.1016/S0165-7208(97)80073-6)

Moret, E.E., Liskamp, R.M.J. and Tollenaere, J.P. (1997) Structure-based design of epitope mimetics. Pharmacochemistry Library, 28, pp. 371-381. (doi: 10.1016/S0165-7208(97)80079-7)

1996

de Bont, D.B.A., Dijkstra, G.D.H., den Hartog, J.A.J. and Liskamp, R.M.J. (1996) Solid-phase synthesis of peptidosulfonamide containing peptides derived from Leu-enkephalin. Bioorganic and Medicinal Chemistry Letters, 6(24), pp. 3035-3040. (doi: 10.1016/S0960-894X(96)00565-3)

de Bont, D.B.A., Moree, W.J. and Liskamp, R.M.J. (1996) Molecular diversity of peptidomimetics: approaches to the solid-phase synthesis of peptidosulfonamides. Bioorganic and Medicinal Chemistry, 4(5), pp. 667-672. (doi: 10.1016/0968-0896(96)00061-2)

Löwik, D.W.P.M., Mulders, S.J.E., Cheng, Y., Shao, Y. and Liskamp, R.M.J. (1996) Synthetic receptors based on peptidosulfonamide peptidomimetics. Tetrahedron Letters, 37(45), pp. 8253-8256. (doi: 10.1016/0040-4039(96)01882-5)

Sliedregt, K.M., Schouten, A., Kroon, J. and Liskamp, R.M.J. (1996) Reaction of N-trityl amino acids with BOP: Efficient synthesis of t-butyl esters as well as N-trityl serine- and threonine-β-lactones. Tetrahedron Letters, 37(24), pp. 4237-4240. (doi: 10.1016/0040-4039(96)00805-2)

1995

Moree, W.J., Schouten, A., Kroon, J. and Liskamp, R.M.J. (1995) Peptides containing the sulfonamide transition-state isostere: synthesis and structure of N-acetyl-tauryl-L-proline methylamide. International Journal of Peptide and Protein Research, 45(6), pp. 501-7. (doi: 10.1111/j.1399-3011.1995.tb01312.x)

1993

Long, A., O'Connell, M., Liskamp, R.M.J. and Kelleher, D. (1993) Regulation of CD3 expression in a protein kinase C isozyme-deficient T-cell line. Immunology, 80(4), pp. 654-7.

Verhoeven, A.J., Leusen, J.H., Kessels, G.C., Hilarius, P.M., de Bont, D.B. and Liskamp, R.M.J. (1993) Inhibition of neutrophil NADPH oxidase assembly by a myristoylated pseudosubstrate of protein kinase C. Journal of Biological Chemistry, 268(25), pp. 18593-8.

Nijenhuis, A.A., Fokkens, R.H., Nibbering, N.M., van Oijen, A.H., de Bont, H.B., Liskamp, R.M.J. and van Boom, J.H. (1993) Verification of the position of the phosphate group in some synthetic phosphopeptides by fast-atom bombardment and tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 7(8), pp. 774-779. (doi: 10.1002/rcm.1290070818)

Eichholtz, T., de Bont, D.B., de Widt, J., Liskamp, R.M.J. and Ploegh, H.L. (1993) A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor. Journal of Biological Chemistry, 268(3), pp. 1982-1986.

Moree, W.J., van der Marel, G.A., van Boom, J.H. and Liskamp, R.M.J. (1993) Peptides containing the novel methylphosphinamide transition-state isostere. Tetrahedron, 49(47), pp. 11055-11064. (doi: 10.1016/S0040-4020(01)80258-1)

Moree, W.J., van Gent, L.C., van der Marel, G.A. and Liskamp, R.M.J. (1993) Synthesis of peptides containing a sulfinamide or a sulfonamide transition-state isostere. Tetrahedron, 49(5), pp. 1133-1150. (doi: 10.1016/S0040-4020(01)86293-1)

1992

Klein-de Gunst, F.J.M., Boom, J.H. and Liskamp, R.M.J. (1992) Computer-aided molecular modeling and design of DNA-inserting molecules. Journal of Computer-Aided Molecular Design, 6(1), pp. 33-46. (doi: 10.1007/BF00124385)

Bol, K.M. and Liskamp, R.M.J. (1992) Synthesis of alkene dipeptide isosteres employing the Wittig-Still rearrangement. Tetrahedron, 48(31), pp. 6425-6438. (doi: 10.1016/S0040-4020(01)88232-6)

Moree, W.J., van der Marel, G.A. and Liskamp, R.M.J. (1992) Synthesis of peptides containing the β-substituted aminoethane sulfinamide or sulfonamide transition-state isostere derived from amino acids. Tetrahedron Letters, 33(42), pp. 6389-6392. (doi: 10.1016/S0040-4039(00)60981-4)

1991

O'Brian, C.A., Ward, N.E., Liskamp, R.M. , de Bont, D.B., Earnest, L.E., van Boom, J.H. and Fan, D. (1991) A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to adriamycin. Investigational New Drugs, 9(2), pp. 169-179. (doi: 10.1007/BF00175084)

Debont, H.B.A., Vanboom, J.H. and Liskamp, R.M.J. (1991) Automatic synthesis of phosphopeptides on the solid-phase. In: Giralt, E. and Andreu, D. (eds.) Peptides 1990. Series: European Peptide Symposia (1). Springer, pp. 443-445. ISBN 9789072199089

Moree, W.J., van der Marel, G.A. and Liskamp, R.M.J. (1991) Peptides containing a sulfinamide or a sulfonamide moiety: new transition-state analogues. Tetrahedron Letters, 32(3), pp. 409-412. (doi: 10.1016/S0040-4039(00)92641-8)

van Oijen, A.H., de Bont, H.B.A., van Boom, J.H. and Liskamp, R.M.J. (1991) Synthesis of an amino acid based phosphodiester linkage containing cryptand. Tetrahedron Letters, 32(52), pp. 7723-7726. (doi: 10.1016/0040-4039(91)80575-Q)

1990

Ioannides, C.G., Freedman, R.S., Liskamp, R.M.J. , Ward, N.E. and O'Brian, C.A. (1990) Inhibition of IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat by a novel peptide inhibitor of protein kinase C. Cellular Immunology, 131(1), pp. 242-252. (doi: 10.1016/0008-8749(90)90250-U)

O'Brian, C.A., Ward, N.E., Liskamp, R.M. , de Bont, D.B. and van Boom, J.H. (1990) N-myristyl-Lys-Arg-Thr-Leu-Arg: a novel protein kinase C inhibitor. Biochemical Pharmacology, 39(1), pp. 49-57. (doi: 10.1016/0006-2952(90)90647-4)

O'Brian, C.A., Ioannides, C.G., Ward, N.E. and Liskamp, R.M. (1990) Inhibition of protein kinase C and calmodulin by the geometric isomers cis- and trans-tamoxifen. Biopolymers, 29(1), pp. 97-104. (doi: 10.1002/bip.360290114)

de Bont, H.B.A., van Boom, J.H. and Liskamp, R.M.J. (1990) Automatic synthesis of phosphopeptides by phosphorylation on the solid phase. Tetrahedron Letters, 31(17), pp. 2497-2500. (doi: 10.1016/S0040-4039(00)97399-4)

1989

Meloen, R.H., Liskamp, R.M. and Goudsmit, J. (1989) Specificity and function of the individual amino acids of an important determinant of human immunodeficiency virus type 1 that induces neutralizing activity. Journal of General Virology, 70(6), pp. 1505-1512. (doi: 10.1099/0022-1317-70-6-1505)

de Bont, H.B., Liskamp, R.M. , O'Brian, C.A., Erkelens, C., Veeneman, G.H. and van Boom, J.H. (1989) Synthesis of a substrate of protein kinase C and its corresponding phosphopeptide. International Journal of Peptide and Protein Research, 33(2), pp. 115-123. (doi: 10.1111/j.1399-3011.1989.tb00196.x)

1987

van den Broek, L.A., Liskamp, R.M. , Colstee, J.H., Lelieveld, P., Remacha, M., Vázquez, D., Ballesta, J.P. and Ottenheijm, H.C. (1987) Structure-activity relationships of sparsomycin and its analogues. Inhibition of peptide bond formation in cell-free systems and of L1210 and bacterial cell growth. Journal of Medicinal Chemistry, 30(2), pp. 325-333. (doi: 10.1021/jm00385a014)

1986

O'Brian, C.A., Liskamp, R.M. , Solomon, D.H. and Weinstein, I.B. (1986) Triphenylethylenes: a new class of protein kinase C inhibitors. Journal of the National Cancer Institute, 76(6), pp. 1243-1246. (doi: 10.1093/jnci/76.6.1243)

Jeffrey, A.M. and Liskamp, R.M. (1986) Computer-assisted molecular modeling of tumor promoters: rationale for the activity of phorbol esters, teleocidin B, and aplysiatoxin. Proceedings of the National Academy of Sciences of the United States of America, 83(2), pp. 241-245.

1985

Liskamp, R.M. , Brothman, A.R., Arcoleo, J.P., Miller, O.J. and Weinstein, I.B. (1985) Cellular uptake and localization of fluorescent derivatives of phorbol ester tumor promoters. Biochemical and Biophysical Research Communications, 131(2), pp. 920-927. (doi: 10.1016/0006-291X(85)91327-0)

O'Brian, C.A., Liskamp, R.M. , Solomon, D.H. and Weinstein, I.B. (1985) Inhibition of protein kinase C by tamoxifen. Cancer Research, 45(6), pp. 2462-2465.

1984

Ash, R.J., Flynn, G.A., Liskamp, R.M. and Ottenheijm, H.C. (1984) Sulfoxide configuration in sparsomycin determines time-dependent and competitive inhibition of peptidyl transferase. Biochemical and Biophysical Research Communications, 125(2), pp. 784-789. (doi: 10.1016/0006-291X(84)90607-7)

Liskamp, R.M. , Colstee, J.H., Ottenheijm, H.C., Lelieveld, P. and Akkerman, W. (1984) Structure-activity relationships of sparsomycin and its analogues. Octylsparsomycin: the first analogue more active than sparsomycin. Journal of Medicinal Chemistry, 27(3), pp. 301-6. (doi: 10.1021/jm00369a012)

Stichting Katholieke Universiteit (1984) Antitumour Sparsomycin-(Sc-Rs) Derivs.|With Higher Cytostatic Activity Than Sparsomycin Itself. .

1983

Winograd, B., Oosterbaan, M.J., van der Kleijn, E., Liskamp, R.M. , Ottenheijm, H.C. and Wagener, D.J. (1983) Determination of sparsomycin in plasma and urine of the dog by means of reversed-phase high-performance liquid chromatography and first pharmacokinetic results. Journal of Chromatography, 275(1), pp. 145-53.

Saris, C.J., van Eenbergen, J., Liskamp, R.M. and Bloemers, H.P. (1983) Structure of glycosylated and unglycosylated gag and gag-pol precursor proteins of Moloney murine leukemia virus. Journal of Virology, 46(3), pp. 841-859.

Katholieke University Research (1983) Functionalised Sultone(S)|Useful In Preparation Of Sparsomycin Etc. By Stereospecific Ring Opening. .

Articles

Timmers, M., Kong, M., Schuckman, P., Meulemans, T., Rijcken, C., Hennink, W., Vermonden, T. and Liskamp, R. M. J. (2024) Silicon‐based linkers for tunable acid‐sensitive drug release from polymeric nanoparticles. Chemistry: A European Journal, (doi: 10.1002/chem.202403589) (Early Online Publication)

Hebels, E. R., Dietl, S., Timmers, M., Hak, J., van den Dikkenberg, A., Rijcken, C. J.F., Hennink, W. E., Liskamp, R.J. and Vermonden, T. (2023) Versatile click linker enabling native peptide release from nanocarriers upon redox trigger. Bioconjugate Chemistry, 34(12), pp. 2375-2386. (doi: 10.1021/acs.bioconjchem.3c00484) (PMID:38079189) (PMCID:PMC10739580)

Timmers, M. et al. (2023) Exploring the chemical properties and medicinal applications of tetramethylthiocycloheptyne sulfoximine used in strain-promoted azide–alkyne cycloaddition reactions. Pharmaceuticals, 16(8), 1155. (doi: 10.3390/ph16081155) (PMID:37631074) (PMCID:PMC10459143)

Timmers, M., Weterings, J., van Geijn, M., Bell, R., Lenting, P. E., Rijcken, C. J.F., Vermonden, T., Hennink, W. E. and Liskamp, R. M.J. (2022) A new class of tunable acid-sensitive linkers for native drug release based on the trityl protecting group. Bioconjugate Chemistry, 33(9), pp. 1707-1715. (doi: 10.1021/acs.bioconjchem.2c00310) (PMID:35979909) (PMCID:PMC9501768)

Massett, M. E. et al. (2021) A KDM4A-PAF1-mediated epigenomic network is essential for acute myeloid leukemia cell self-renewal and survival. Cell Death and Disease, 12(6), 573. (doi: 10.1038/s41419-021-03738-0) (PMID:34083515) (PMCID:PMC8175737)

Meuleman, T. J., Cowton, V. M., Patel, A. H. and Liskamp, R. M.J. (2021) Design and synthesis of HCV-E2 glycoprotein epitope mimics in the molecular construction of potential as synthetic vaccines. Viruses, 13(2), 326. (doi: 10.3390/v13020326) (PMID:33672697) (PMCID:PMC7924389)

Weterings, J., Rijcken, C. J.F., Veldhuis, H., Meulemans, T., Hadavi, D., Timmers, M., Honing, M., Ippel, H. and Liskamp, R. M.J. (2020) TMTHSI, a superior 7-membered ring alkyne containing reagent for strain-promoted azide-alkyne cycloaddition reactions. Chemical Science, 11(33), pp. 9011-9016. (doi: 10.1039/D0SC03477K) (PMID:34123155) (PMCID:PMC8163418)

Meuleman, T. J., Cowton, V. M., Patel, A. H. and Liskamp, R. M.J. (2020) Improving the aqueous solubility of HCV-E2 glycoprotein epitope mimics by cyclization using polar hinges. Journal of Peptide Science, 26(1), e3222. (doi: 10.1002/psc.3222) (PMID:31984607)

Hoeksma, J. et al. (2019) A new perspective on fungal metabolites: identification of bioactive compounds from fungi using zebrafish embryogenesis as read-out. Scientific Reports, 9, 17546. (doi: 10.1038/s41598-019-54127-9) (PMID:31772307) (PMCID:PMC6879544)

Monaghan, L., Massett, M. E., Bunschoten, R. P., Hoose, A., Pirvan, P.-A., Liskamp, R. M.J. , Jørgensen, H. G. and Huang, X. (2019) The emerging role of H3K9me3 as a potential therapeutic target in acute myeloid leukaemia. Frontiers in Oncology, 9, 705. (doi: 10.3389/fonc.2019.00705) (PMID:31428579) (PMCID:PMC6687838)

Ward, D.J., Van de Langemheen, H., Koehne, E., Kreidenweiss, A. and Liskamp, R.M.J. (2019) Highly tunable thiosulfonates as a novel class of cysteine protease inhibitors with anti-parasitic activity against Schistosoma mansoni. Bioorganic and Medicinal Chemistry, 27(13), pp. 2857-2870. (doi: 10.1016/j.bmc.2019.05.014) (PMID:31126821)

Müskens, F. M., Ward, R. J., Herkt, D., van de Langemheen, H., Tobin, A. B. , Liskamp, R. M.J. and Milligan, G. (2019) Design, synthesis and evaluation of a diazirine photoaffinity probe for ligand-based receptor capture targeting G protein-coupled receptors. Molecular Pharmacology, 95(2), pp. 196-209. (doi: 10.1124/mol.118.114249) (PMID:30514721) (PMCID:PMC6324650)

Korotkovs, V., Reichenbach, L. F., Pescheteau, C., Burley, G. A. and Liskamp, R. M.J. (2019) Molecular construction of sulfonamide antisense oligonucleotides. Journal of Organic Chemistry, 84(17), pp. 10635-10648. (doi: 10.1021/acs.joc.9b00941)

Guardiola, S., Prades, R., Mendieta, L., Brouwer, A. J., Streefkerk, J., Nevola, L., Tarragó, T., Liskamp, R. M.J. and Giralt, E. (2018) Targeted covalent inhibition of prolyl oligopeptidase (POP): discovery of sulfonylfluoride peptidomimetics. Cell Chemical Biology, 25(8), 1037-1037.e4. (doi: 10.1016/j.chembiol.2018.04.013) (PMID:29779956)

Longin, O., Hezwani, M., van de Langemheen, H. and Liskamp, R. M.J. (2018) Synthetic antibody protein mimics of infliximab by molecular scaffolding on novel CycloTriVeratrilene (CTV) derivatives. Organic and Biomolecular Chemistry, 16(29), pp. 5254-5274. (doi: 10.1039/c8ob01104d) (PMID:29892733)

Artschwager, R., Ward, D. J., Gannon, S., Brouwer, A. J., van de Langemheen, H., Kowalski, H. and Liskamp, R. M.J. (2018) Potent and highly selective inhibitors of the proteasome trypsin-like site by incorporation of basic side chain containing amino acid derived sulfonyl fluorides. Journal of Medicinal Chemistry, 61(12), pp. 5395-5411. (doi: 10.1021/acs.jmedchem.8b00685) (PMID:29782167)

Silva Nigenda, E., Postma, T., Hezwani, M., Pirvan, A., Gannon, S., Smith, C.-A. , Riehle, M. and Liskamp, R. M.J. (2018) Synthesis and cellular penetration properties of new phosphonium based cationic amphiphilic peptides. MedChemComm, 9(6), pp. 982-987. (doi: 10.1039/c8md00113h)

Morrison, S. D. , Liskamp, R. M.J. and Prunet, J. (2018) Tailoring polyethers for efficient post-polymerization functionalization by cross metathesis. Organic Letters, 20(8), pp. 2253-2256. (doi: 10.1021/acs.orglett.8b00595) (PMID:29600865)

Meuleman, T. J., Dunlop, J. I., Owsianka, A. M., van de Langemheen, H., Patel, A. H. and Liskamp, R. M.J. (2018) Immobilization by surface conjugation of cyclic peptides for effective mimicry of the HCV-envelope E2 protein as a strategy toward synthetic vaccines. Bioconjugate Chemistry, 29(4), pp. 1091-1101. (doi: 10.1021/acs.bioconjchem.7b00755) (PMID:29382188)

Yang, X., Beroske, L. P., Kemmink, J., Rijkers, D. T.S. and Liskamp, R. M.J. (2017) Synthesis of bicyclic tripeptides inspired by the ABC-ring system of vancomycin through ruthenium-based cyclization chemistries. Tetrahedron Letters, 58(48), pp. 4542-4546. (doi: 10.1016/j.tetlet.2017.10.046)

Herrero Alvarez, N., Van De Langemheen, H., Brouwer, A. J. and Liskamp, R. M.J. (2017) Potential peptidic proteasome inhibitors by incorporation of an electrophilic trap based on amino acid derived α-substituted sulfonyl fluorides. Bioorganic and Medicinal Chemistry, 25(19), pp. 5055-5063. (doi: 10.1016/j.bmc.2017.07.019) (PMID:28734665)

Longin, O., Van De Langemheen, H. and Liskamp, R. M.J. (2017) An orthogonally protected CycloTriVeratrylene (CTV) as a highly pre-organized molecular scaffold for subsequent ligation of different cyclic peptides towards protein mimics. Bioorganic and Medicinal Chemistry, 25(18), pp. 5008-5015. (doi: 10.1016/j.bmc.2017.05.038) (PMID:28583807)

Van De Langemheen, H., Korotkovs, V., Bijl, J., Wilson, C. , Kale, S. S., Heinis, C. and Liskamp, R. M.J. (2017) Polar hinges as functionalized conformational constraints in (bi)cyclic peptides. ChemBioChem, 18(4), pp. 387-395. (doi: 10.1002/cbic.201600612) (PMID:27982494)

O'Connor, C. et al. (2016) The presence of C/EBPα and its degradation are both required for TRIB2 mediated leukaemia. Oncogene, 35(40), pp. 5272-5281. (doi: 10.1038/onc.2016.66) (PMID:26996668)

Brouwer, A. J., Herrero Álvarez, N., Ciaffoni, A., van de Langemheen, H. and Liskamp, R. M.J. (2016) Proteasome inhibition by new dual warhead containing peptido vinyl sulfonyl fluorides. Bioorganic and Medicinal Chemistry, 24(16), pp. 3429-3435. (doi: 10.1016/j.bmc.2016.05.042) (PMID:27316540)

Postma, T.M. and Liskamp, R.M.J. (2016) Highly potent antimicrobial peptide derivatives of bovine cateslytin. RSC Advances, 6(97), pp. 94840-94844. (doi: 10.1039/c6ra17944d)

Postma, T.M. and Liskamp, R.M.J. (2016) Triple-targeting Gram-negative selective antimicrobial peptides capable of disrupting the cell membrane and lipid A biosynthesis. RSC Advances, 6(70), pp. 65418-65421. (doi: 10.1039/c6ra11550k)

Werkhoven, P.R., Elwakiel, M., Meuleman, T.J., Quarles van Ufford, H.C., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2016) Molecular construction of HIV-gp120 discontinuous epitope mimics by assembly of cyclic peptides on an orthogonal alkyne functionalized TAC-scaffold. Organic and Biomolecular Chemistry, 14(2), pp. 701-710. (doi: 10.1039/c5ob02014j) (PMID:26552661)

Gilfillan, L., Artschwager, R., Harkiss, A. H., Liskamp, R. M.J. and Sutherland, A. (2015) Synthesis of pyrazole containing α-amino acids via a highly regioselective condensation/aza-Michael reaction of β-aryl α,β-unsaturated ketones. Organic and Biomolecular Chemistry, 13(15), pp. 4514-4523. (doi: 10.1039/C5OB00364D) (PMID:25774874)

Dubiella, C., Cui, H., Gersch, M., Brouwer, A. J., Sieber, S. A., Krüger, A., Liskamp, R. M.J. and Groll, M. (2014) Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site. Angewandte Chemie (International Edition), 53(44), pp. 11969-11973. (doi: 10.1002/anie.201406964) (PMID:25244435)

Harmsen, R. A.G., Ghalit, N., Kemmink, J., Breukink, E., Liskamp, R. M.J. and Rijkers, D. T.S. (2014) A conformationally constrained fused tricyclic nisin AB-ring system mimic toward an improved pyrophosphate binder of lipid II. Tetrahedron, 70(42), pp. 7691-7699. (doi: 10.1016/j.tet.2014.06.023)

Slootweg, J. C., Peters, N., Quarles van Ufford, H. (L.) C., Breukink, E., Liskamp, R. M.J. and Rijkers, D. T.S. (2014) Semi-synthesis of biologically active nisin hybrids composed of the native lanthionine ABC-fragment and a cross-stapled synthetic DE-fragment. Bioorganic and Medicinal Chemistry, 22(19), pp. 5345-5353. (doi: 10.1016/j.bmc.2014.07.046) (PMID:25199583)

Brouwer, A. J., Van De Langemheen, H. and Liskamp, R. M.J. (2014) Expedient synthesis of a novel asymmetric selectively deprotectable derivative of the ATAC scaffold. Tetrahedron, 70(26), pp. 4002-4007. (doi: 10.1016/j.tet.2014.04.084)

Brouwer, A. J., van de Langemheen, H., Ciaffoni, A., Schilder, K. E. and Liskamp, R. M.J. (2014) Synthesis of the TACO scaffold as a new selectively deprotectable conformationally restricted triazacyclophane based scaffold. Organic Letters, 16(11), pp. 3106-3109. (doi: 10.1021/ol5012218) (PMID:24856258)

González-Ortiz, G., Quarles Van Ufford, H. C., Halkes, S. B. A., Cerdà-Cuéllar, M., Beukelman, C. J., Pieters, R. J., Liskamp, R. M. J. , Pérez, J. F. and Martín-Orue, S. M. (2014) New properties of wheat bran: anti-biofilm activity and interference with bacteria quorum-sensing systems. Environmental Microbiology, 16(5), pp. 1346-1353. (doi: 10.1111/1462-2920.12441)

van de Langemheen, H., Quarles van Ufford, H. (L.) C., Kruijtzer, J. A. W. and Liskamp, R. M.J. (2014) Efficient synthesis of protein mimics by sequential native chemical ligation. Organic Letters, 16(8), pp. 2138-2141. (doi: 10.1021/ol500604h)

Werkhoven, P. R., van de Langemheen, H., van der Wal, S., Kruijtzer, J. A. W. and Liskamp, R. M.J. (2014) Versatile convergent synthesis of a three peptide loop containing protein mimic of whooping cough pertactin by successive Cu(I)-catalyzed azide alkyne cycloaddition on an orthogonal alkyne functionalized TAC-scaffold. Journal of Peptide Science, 20(4), pp. 235-239. (doi: 10.1002/psc.2624) (PMID:24599619)

van Ameijde, J., Overvoorde, J., Knapp, S., den Hertog, J., Ruijtenbeek, R. and Liskamp, R. M.J. (2014) A versatile spectrophotometric protein tyrosine phosphatase assay based on 3-nitrophosphotyrosine containing substrates. Analytical Biochemistry, 448, pp. 9-13. (doi: 10.1016/j.ab.2013.11.023)

van Ameijde, J., Zwiebel, A. P. R., Ruijtenbeek, R. and Liskamp, R. M. J. (2014) Azide–alkyne cycloaddition affording enzymatically tunable bisubstrate based inhibitors of histone acetyltransferase PCAF. Bioorganic and Medicinal Chemistry Letters, 24(1), pp. 113-116. (doi: 10.1016/j.bmcl.2013.11.060)

van der Wal, S., Fu, O., Rontogianni, S., Pieters, R. and Liskamp, R. M. J. (2014) Convenient stereoselective synthesis of substituted ureido glycosides using stable 4-chlorophenylcarbamates without the requirement of lewis acids. Synlett, 25(02), pp. 205-208. (doi: 10.1055/s-0033-1340220)

Cleophas, R. T.C., Riool, M., Quarles van Ufford, H. (L.) C., Zaat, S. A.J., Kruijtzer, J. A.W. and Liskamp, R. M.J. (2014) Convenient preparation of bactericidal hydrogels by covalent attachment of stabilized antimicrobial peptides using thiol–ene click chemistry. ACS Macro Letters, 3(5), pp. 477-480. (doi: 10.1021/mz5001465)

Cleophas, R. T.C., Sjollema, J., Busscher, H. J., Kruijtzer, J. A.W. and Liskamp, R. M.J. (2014) Characterization and activity of an immobilized antimicrobial peptide containing bactericidal PEG-hydrogel. Biomacromolecules, 15(9), pp. 3390-3395. (doi: 10.1021/bm500899r) (PMID:25109707)

van de Langemheen, H., van Hoeke, M., Quarles van Ufford, H.C., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2014) Scaffolded multiple cyclic peptide libraries for protein mimics by native chemical ligation. Organic and Biomolecular Chemistry, 12(25), pp. 4471-4478. (doi: 10.1039/c4ob00190g) (PMID:24849139)

van der Wal, S., Capicciotti, C. J., Rontogianni, S., Ben, R. N. and Liskamp, R. M.J. (2014) Synthesis and evaluation of linear CuAAC-oligomerized antifreeze neo-glycopeptides. MedChemComm, 5(8), pp. 1159-1165. (doi: 10.1039/c4md00013g)

Slootweg, J. C., van der Wal, S., Quarles van Ufford, H. C., Breukink, E., Liskamp, R. M. J. and Rijkers, D. T. S. (2013) Synthesis, antimicrobial activity, and membrane permeabilizing properties of C-terminally modified nisin conjugates accessed by CuAAC. Bioconjugate Chemistry, 24(12), pp. 2058-2066. (doi: 10.1021/bc400401k)

Slootweg, J. C., Kemmink, J., Liskamp, R. M. J. and Rijkers, D. T. S. (2013) Synthesis and structural characterization of the individual diastereoisomers of a cross-stapled alkene-bridged nisin DE-ring mimic. Organic and Biomolecular Chemistry, 11(43), pp. 7486-7496. (doi: 10.1039/c3ob41359d)

Slootweg, J. C., Liskamp, R. M. J. and Rijkers, D. T. S. (2013) Scalable purification of the lantibiotic nisin and isolation of chemical/enzymatic cleavage fragments suitable for semi-synthesis. Journal of Peptide Science, 19(11), pp. 692-699. (doi: 10.1002/psc.2551)

van Ameijde, J., Overvoorde, J., Knapp, S., den Hertog, J., Ruijtenbeek, R. and Liskamp, R. M. J. (2013) Real-time monitoring of the dephosphorylating activity of protein tyrosine phosphatases using microarrays with 3-nitrophosphotyrosine substrates. ChemPlusChem, 78(11), pp. 1349-1357. (doi: 10.1002/cplu.201300299)

Tschan, S. et al. (2013) Broad-spectrum antimalarial activity of peptido sulfonyl fluorides, a new class of proteasome inhibitors. Antimicrobial Agents and Chemotherapy, 57(8), pp. 3576-3584. (doi: 10.1128/AAC.00742-12)

van Wandelen, L. T. M., van Ameijde, J., Ismail-Ali, A. F., van Ufford, H. C. (L.) Q., Vijftigschild, L. A. W., Beekman, J. M., Martin, N. I., Ruijtenbeek, R. and Liskamp, R. M. J. (2013) Cell-penetrating bisubstrate-based protein kinase C inhibitors. ACS Chemical Biology, 8(7), pp. 1479-1487. (doi: 10.1021/cb300709g)

Slootweg, J. C., van Schaik, T. B., Quarles van Ufford, H. (L.) C., Breukink, E., Liskamp, R. M. J. and Rijkers, D. T.S. (2013) Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative. Bioorganic and Medicinal Chemistry Letters, 23(13), pp. 3749-3752. (doi: 10.1016/j.bmcl.2013.05.002)

Zhang, J., Kemmink, J., Rijkers, D. T. S. and Liskamp, R. M. J. (2013) Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization. Chemical Communications, 49(40), pp. 4498-4500. (doi: 10.1039/c3cc40628h)

Mulder, G. E., Quarles van Ufford, H. (L.). C., van Ameijde, J., Brouwer, A. J., Kruijtzer, J. A. W. and Liskamp, R. M. J. (2013) Scaffold optimization in discontinuous epitope containing protein mimics of gp120 using smart libraries. Organic and Biomolecular Chemistry, 11(16), pp. 2676-2684. (doi: 10.1039/c3ob27470e)

Vosyka, O., Vinothkumar, K.R., Wolf, E.V., Brouwer, A.J., Liskamp, R.M.J. and Verhelst, S.H.L. (2013) Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay. Proceedings of the National Academy of Sciences of the United States of America, 110(7), pp. 2472-2477. (doi: 10.1073/pnas.1215076110)

Nuijens, T., Schepers, A.H.M., Cusan, C., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2013) Enzymatic fragment condensation of side chain-protected peptides using subtilisin A in anhydrous organic solvents: a general strategy for industrial peptide synthesis. Advanced Synthesis & Catalysis, 355(2-3), pp. 287-293. (doi: 10.1002/adsc.201200694)

de Mol, N.J., Kruijtzer, J.A.W., Moret, E.E., Broutin, I. and Liskamp, R.M.J. (2013) Unusual binding of Grb2 protein to a bivalent polyproline-ligand immobilized on a SPR sensor: intermolecular bivalent binding. Biochimica et Biophysica Acta: Proteins and Proteomics, 1834(2), pp. 524-535. (doi: 10.1016/j.bbapap.2012.11.001)

van Wandelen, L.T.M., van Ameijde, J., Mady, A.S.A., Wammes, A.E.M., Bode, A., Poot, A.J., Ruijtenbeek, R. and Liskamp, R.M.J. (2012) Directed modulation of protein kinase C isozyme selectivity with bisubstrate-based inhibitors. ChemMedChem, 7(12), pp. 2113-2121. (doi: 10.1002/cmdc.201200349)

van de Langemheen, H., Brouwer, A.J., Kemmink, J., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2012) Synthesis of cyclic peptides containing a thioester handle for native chemical ligation. Journal of Organic Chemistry, 77(22), pp. 10058-10064. (doi: 10.1021/jo3015566)

Shinde, S., Bunschoten, A., Kruijtzer, J.A.W., Liskamp, R.M.J. and Sellergren, B. (2012) Imprinted polymers displaying high affinity for sulfated protein fragments. Angewandte Chemie (International Edition), 51(33), pp. 8326-8329. (doi: 10.1002/anie.201201314)

Mulder, M.P.C., Fodran, P., Kemmink, J., Breukink, E.J., Kruijtzer, J.A.W., Minnaard, A.J. and Liskamp, R.M.J. (2012) Mutual influence of backbone proline substitution and lipophilic tail character on the biological activity of simplified analogues of caspofungin. Organic and Biomolecular Chemistry, 10(37), pp. 7491-7502. (doi: 10.1039/c2ob25951f)

Nuijens, T., Piva, E., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2012) Enzymatic C-terminal amidation of amino acids and peptides. Tetrahedron Letters, 53(29), pp. 3777-3779. (doi: 10.1016/j.tetlet.2012.05.039)

Crielaard, B.J. et al. (2012) Glucocorticoid-loaded core-cross-linked polymeric micelles with tailorable release kinetics for targeted therapy of rheumatoid arthritis. Angewandte Chemie (International Edition), 51(29), pp. 7254-7258. (doi: 10.1002/anie.201202713)

Görmer, K., Bürger, M., Kruijtzer, J.A.W., Vetter, I., Vartak, N., Brunsveld, L., Bastiaens, P.I.H., Liskamp, R.M.J. , Triola, G. and Waldmann, H. (2012) Chemical-biological exploration of the limits of the ras de- and repalmitoylating machinery. ChemBioChem, 13(7), pp. 1017-1023. (doi: 10.1002/cbic.201200078)

de Graaf, A.J., Mastrobattista, E., Vermonden, T., van Nostrum, C., Rijkers, D.T.S., Liskamp, R.M.J. and Hennink, W.E. (2012) Thermosensitive peptide-hybrid ABC block copolymers obtained by ATRP: synthesis, self-assembly, and enzymatic degradation. Macromolecules, 45(2), pp. 842-851. (doi: 10.1021/ma2024667)

Albada, H.B., Soulimani, F., Jacobs, H.J.F., Versluis, C., Weckhuysen, B.M. and Liskamp, R.M.J. (2012) Triazacyclophane (TAC)-scaffolded histidine and aspartic acid residues as mimics of non-heme metalloenzyme active sites. Organic and Biomolecular Chemistry, 10(5), pp. 1088-1092. (doi: 10.1039/c1ob06806g)

Arnusch, C.J., Albada, H.B., van Vaardegem, M., Liskamp, R.M.J. , Sahl, H.-G., Shadkchan, Y., Osherov, N. and Shai, Y. (2012) Trivalent ultrashort lipopeptides are potent pH dependent antifungal agents. Journal of Medicinal Chemistry, 55(3), pp. 1296-1302. (doi: 10.1021/jm2014474)

Brouwer, A.J. et al. (2012) Peptido sulfonyl fluorides as new powerful proteasome inhibitors. Journal of Medicinal Chemistry, 55(24), pp. 10995-11003. (doi: 10.1021/jm301443r)

Mulder, G.E., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2012) A combinatorial approach toward smart libraries of discontinuous epitopes of HIV gp120 on a TAC synthetic scaffold. Chemical Communications, 48(80), p. 10007. (doi: 10.1039/c2cc35310e)

Rijkers, D.T.S., de Prada López, F., Liskamp, R.M.J. and Diederich, F. (2011) A convenient [2+2] cycloaddition–cycloreversion reaction for the synthesis of 1,1-dicyanobuta-1,3-diene-scaffolded peptides as new imaging chromophores. Tetrahedron Letters, 52(51), pp. 6963-6967. (doi: 10.1016/j.tetlet.2011.10.084)

Mulder, M.P.C., Kruijtzer, J.A.W., Breukink, E.J., Kemmink, J., Pieters, R.J. and Liskamp, R.M.J. (2011) Synthesis and evaluation of novel macrocyclic antifungal peptides. Bioorganic and Medicinal Chemistry, 19(21), pp. 6505-6517. (doi: 10.1016/j.bmc.2011.08.034)

Nyholm, T.K.M., van Duyl, B., Rijkers, D.T.S., Liskamp, R.M.J. and Killian, J.A. (2011) Probing the lipid-protein interface using model transmembrane peptides with a covalently linked acyl chain. Biophysical Journal, 101(8), pp. 1959-1967. (doi: 10.1016/j.bpj.2011.09.020)

Liskamp, R.M.J. and Brouwer, A. (2011) A simple large-scale synthesis of Cbz-protected taurylsulfonyl azide. Synlett, 2011(15), pp. 2228-2230. (doi: 10.1055/s-0030-1261201)

Liskamp, R.M.J. , Rijkers, D.T.S., Kruijtzer, J.A.W. and Kemmink, J. (2011) Peptides and proteins as a continuing exciting source of inspiration for peptidomimetics. ChemBioChem, 15, pp. 2228-2230. (doi: 10.1002/cbic.201000717)

Nuijens, T., Cusan, C., Schepers, A.C.H.M., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2011) Enzymatic synthesis of activated esters and their subsequent use in enzyme-based peptide synthesis. Journal of Molecular Catalysis B: Enzymatic, 71(1-2), pp. 79-84. (doi: 10.1016/j.molcatb.2011.03.012)

Nuijens, T., Piva, E., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2011) Fully enzymatic N→C-directed peptide synthesis using C-terminal peptide α-carboxamide to ester interconversion. Advanced Synthesis & Catalysis, 353(7), pp. 1039-1044. (doi: 10.1002/adsc.201000943)

Brouwer, A.J., Ceylan, T., Jonker, A.M., Linden, T. and Liskamp, R.M.J. (2011) Synthesis and biological evaluation of novel irreversible serine protease inhibitors using amino acid based sulfonyl fluorides as an electrophilic trap. Bioorganic and Medicinal Chemistry, 19(7), pp. 2397-2406. (doi: 10.1016/j.bmc.2011.02.014)

Yim, C.-B., van der Wildt, B., Dijkgraaf, I., Joosten, L., Eek, A., Versluis, C., Rijkers, D.T.S., Boerman, O.C. and Liskamp, R.M.J. (2011) Spacer effects on in vivo properties of DOTA-conjugated dimeric [Tyr3]octreotate peptides synthesized by a “CuI-Click” and “Sulfo-Click” ligation method. ChemBioChem, 12(5), pp. 750-760. (doi: 10.1002/cbic.201000639)

Bauke Albada, H., Rosati, F., Coquière, D., Roelfes, G. and Liskamp, R.M.J. (2011) Enantioselective cuII-catalyzed diels-alder and michael addition reactions in water using bio-inspired triazacyclophane-based ligands. European Journal of Organic Chemistry, 2011(9), pp. 1714-1720. (doi: 10.1002/ejoc.201001522)

Bunschoten, A., Ippel, J.H., Kruijtzer, J.A.W., Feitsma, L., Haas, C.J.C., Liskamp, R.M.J. and Kemmink, J. (2011) A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds. Amino Acids, 40(2), pp. 731-740. (doi: 10.1007/s00726-010-0711-3)

Kuil, J., Fischer, M.J.E., de Mol, N.J. and Liskamp, R.M.J. (2011) Cell permeable ITAM constructs for the modulation of mediator release in mast cells. Organic and Biomolecular Chemistry, 9(3), p. 820. (doi: 10.1039/c0ob00441c)

Zhang, J., Kemmink, J., Rijkers, D.T.S. and Liskamp, R.M.J. (2011) Cu(I)- and Ru(II)-mediated “click” cyclization of tripeptides toward vancomycin-inspired mimics. Organic Letters, 13(13), pp. 3438-3441. (doi: 10.1021/ol201184b)

Nuijens, T., Cusan, C., van Dooren, T.J.G.M., Moody, H.M., Merkx, R., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2010) Fully enzymatic peptide synthesis using C-terminal tert-butyl ester interconversion. Advanced Synthesis & Catalysis, 352(14-15), pp. 2399-2404. (doi: 10.1002/adsc.201000313)

Parera Pera, N., Branderhorst, H.M., Kooij, R., Maierhofer, C., van der Kaaden, M., Liskamp, R.M.J. , Wittmann, V., Ruijtenbeek, R. and Pieters, R.J. (2010) Rapid screening of lectins for multivalency effects with a glycodendrimer microarray. ChemBioChem, 11(13), pp. 1896-1904. (doi: 10.1002/cbic.201000340)

Khemtémourian, L., Engel, M.F.M., Liskamp, R.M.J. , Höppener, J.W.M. and Killian, J.A. (2010) The N-terminal fragment of human islet amyloid polypeptide is non-fibrillogenic in the presence of membranes and does not cause leakage of bilayers of physiologically relevant lipid composition. Biochimica et Biophysica Acta: Biomembranes, 1798(9), pp. 1805-1811. (doi: 10.1016/j.bbamem.2010.05.022)

Khemtémourian, L., Engel, M.F.M., Kruijtzer, J.A.W., Höppener, J.W.M., Liskamp, R.M.J. and Killian, J.A. (2010) The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes. European Biophysics Journal with Biophysics Letters, 39(9), pp. 1359-1364. (doi: 10.1007/s00249-009-0572-4)

Arnusch, C.J., Ippel, J.H., Kooijman, H., Spek, A.L., Liskamp, R.M.J. , Kemmink, J. and Pieters, R.J. (2010) Direct structural comparison of a rigid cyclic peptidic scaffold using crystallography and NMR in strained PH polymer gels. European Journal of Organic Chemistry, 2010(23), pp. 4501-4507. (doi: 10.1002/ejoc.201000440)

Dekker, F.J., DE Mol, N.J. and Liskamp, R.M.J. (2010) Thermodynamics of phosphotyrosine peptide-peptoid hybrids binding to the p56^lck SH2 domain. Journal of Peptide Science, 16(7), pp. 322-328. (doi: 10.1002/psc.1242)

Bunschoten, A., Feitsma, L.J., Kruijtzer, J.A.W., de Haas, C.J.C., Liskamp, R.M.J. and Kemmink, J. (2010) CHIPS binds to the phosphorylated N-terminus of the C5a-receptor. Bioorganic and Medicinal Chemistry Letters, 20(11), pp. 3338-3340. (doi: 10.1016/j.bmcl.2010.04.028)

van Dijk, M., Postma, T.M., Rijkers, D.T.S., Liskamp, R.M.J. , van Nostrum, C.F. and Hennink, W.E. (2010) Synthesis and characterization of tailorable biodegradable thermoresponsive methacryloylamide polymers based on l-serine and l-threonine alkyl esters. Polymer, 51(12), pp. 2479-2485. (doi: 10.1016/j.polymer.2010.04.010)

van Ameijde, J., Slot, T.K. and Liskamp, R.M.J. (2010) Towards the synthesis of sulfonamide-based RNA mimetics. Tetrahedron: Asymmetry, 21(4), pp. 469-475. (doi: 10.1016/j.tetasy.2010.02.005)

van Scherpenzeel, M., van den Berg, R.J.B.H.N., Donker-Koopman, W.E., Liskamp, R.M.J. , Aerts, J.M.F.G., Overkleeft, H.S. and Pieters, R.J. (2010) Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase. Bioorganic and Medicinal Chemistry, 18(1), pp. 267-273. (doi: 10.1016/j.bmc.2009.10.060)

Pera, N.P., Kouki, A., Haataja, S., Branderhorst, H.M., Liskamp, R.M.J. , Visser, G.M., Finne, J. and Pieters, R.J. (2010) Detection of pathogenic streptococcus suis bacteria using magnetic glycoparticles. Organic and Biomolecular Chemistry, 8, pp. 2425-2429. (doi: 10.1039/c000819b)

van Ameijde, J., Poot, A.J., van Wandelen, L.T.M., Wammes, A.E.M., Ruijtenbeek, R., Rijkers, D.T.S. and Liskamp, R.M.J. (2010) Preparation of novel alkylated arginine derivatives suitable for click-cycloaddition chemistry and their incorporation into pseudosubstrate- and bisubstrate-based kinase inhibitors. Organic and Biomolecular Chemistry, 8(7), pp. 1629-1639. (doi: 10.1039/b922928k)

van Dijk, M., van Nostrum, C.F., Hennink, W.E., Rijkers, D.T.S. and Liskamp, R.M.J. (2010) Synthesis and characterization of enzymatically biodegradable PEG and peptide-based hydrogels prepared by click chemistry. Biomacromolecules, 11(6), pp. 1608-1614. (doi: 10.1021/bm1002637)

Yim, C.-B., Dijkgraaf, I., Merkx, R., Versluis, C., Eek, A., Mulder, G.E., Rijkers, D.T.S., Boerman, O.C. and Liskamp, R.M.J. (2010) Synthesis of DOTA-conjugated multimeric [Tyr3]octreotide peptides via a combination of Cu(I)-catalyzed "click" cycloaddition and thio acid/sulfonyl azide "sulfo-Click" Amidation and Their in Vivo Evaluation. Journal of Medicinal Chemistry, 53(10), pp. 3944-3953. (doi: 10.1021/jm100246m)

Kuil, J., van Wandelen, L.T.M., de Mol, N.J. and Liskamp, R.M.J. (2009) Switching between low and high affinity for the Syk tandem SH2 domain by irradiation of azobenzene containing ITAM peptidomimetics. Journal of Peptide Science, 15(10), pp. 685-691. (doi: 10.1002/psc.1173)

Poot, A.J., van Ameijde, J., Slijper, M., van den Berg, A., Hilhorst, R., Ruijtenbeek, R., Rijkers, D.T.S. and Liskamp, R.M.J. (2009) Development of selective bisubstrate-based inhibitors against protein kinase C (PKC) isozymes by using dynamic peptide microarrays. ChemBioChem, 10(12), pp. 2042-2051. (doi: 10.1002/cbic.200900199)

Bauke Albada, H., Arnusch, C.J., Branderhorst, H.M., Verel, A.-M., Janssen, W.T.M., Breukink, E., de Kruijff, B., Pieters, R.J. and Liskamp, R.M.J. (2009) Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin–TACzyme conjugates and modulation of their antibacterial activity by Zn-ions. Bioorganic and Medicinal Chemistry Letters, 19(14), pp. 3721-3724. (doi: 10.1016/j.bmcl.2009.05.064)

van Scherpenzeel, M., Moret, E.E., Ballell, L., Liskamp, R.M.J. , Nilsson, U.J., Leffler, H. and Pieters, R.J. (2009) Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3. ChemBioChem, 10(10), pp. 1724-1733. (doi: 10.1002/cbic.200900198)

Brouwer, A.J., Ceylan, T., van der Linden, T. and Liskamp, R.M.J. (2009) Synthesis of β-aminoethanesulfonyl fluorides or 2-substituted taurine sulfonyl fluorides as potential protease inhibitors. Tetrahedron Letters, 50(26), pp. 3391-3393. (doi: 10.1016/j.tetlet.2009.02.130)

Nuijens, T., Kruijtzer, J.A.W., Cusan, C., Rijkers, D.T.S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2009) A versatile and selective chemo-enzymatic synthesis of β-protected aspartic and γ-protected glutamic acid derivatives. Tetrahedron Letters, 50(23), pp. 2719-2721. (doi: 10.1016/j.tetlet.2009.03.130)

Ippel, J.H., de Haas, C.J.C., Bunschoten, A., van Strijp, J.A.G., Kruijtzer, J.A.W., Liskamp, R.M.J. and Kemmink, J. (2009) Structure of the tyrosine-sulfated C5a receptor N terminus in complex with chemotaxis inhibitory protein of Staphylococcus aureus. Journal of Biological Chemistry, 284(18), pp. 12363-12372. (doi: 10.1074/jbc.M808179200)

Teertstra, W.R., van der Velden, G.J., de Jong, J.F., Kruijtzer, J.A.W., Liskamp, R.M.J. , Kroon-Batenburg, L.M.J., Muller, W.H., Gebbink, M.F.B.G. and Wosten, H.A.B. (2009) The filament-specific Rep1-1 repellent of the phytopathogen ustilago maydis forms functional surface-active amyloid-like fibrils. Journal of Biological Chemistry, 284(14), pp. 9153-9159. (doi: 10.1074/jbc.M900095200)

Gubbens, J., Ruijter, E., de Fays, L.E.V., Damen, J.M.A., de Kruijff, B., Slijper, M., Rijkers, D.T.S., Liskamp, R.M.J. and de Kroon, A.I.P.M. (2009) Photocrosslinking and click chemistry enable the specific detection of proteins interacting with phospholipids at the membrane interface. Chemistry and Biology, 16(1), pp. 3-14. (doi: 10.1016/j.chembiol.2008.11.009)

Bunschoten, A., Kruijtzer, J.A.W., Ippel, J.H., de Haas, C.J.C., van Strijp, J.A.G., Kemmink, J. and Liskamp, R.M.J. (2009) A general sequence independent solid phase method for the site specific synthesis of multiple sulfated-tyrosine containing peptides. Chemical Communications(21), pp. 2999-3001. (doi: 10.1039/b823425f)

Chamorro, C., Kruijtzer, J.A.W., Farsaraki, M., Balzarini, J. and Liskamp, R.M.J. (2009) A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes. Chemical Communications(7), pp. 821-823. (doi: 10.1039/b817357e)

Elgersma, R.C., van Dijk, M., Dechesne, A.C., van Nostrum, C.F., Hennink, W.E., Rijkers, D.T.S. and Liskamp, R.M.J. (2009) Microwave-assisted click polymerization for the synthesis of Aβ(16–22) cyclic oligomers and their self-assembly into polymorphous aggregates. Organic and Biomolecular Chemistry, 7(21), pp. 4517-4525. (doi: 10.1039/b912851d)

Kuil, J., Branderhorst, H.M., Pieters, R.J., de Mol, N.J. and Liskamp, R.M.J. (2009) ITAM-derived phosphopeptide-containing dendrimers as multivalent ligands for Syk tandem SH2 domain. Organic and Biomolecular Chemistry, 7(19), pp. 4088-4094. (doi: 10.1039/b905938e)

Nuijens, T., Cusan, C., Kruijtzer, J.A.W., Rijkers, D.T. S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2009) Enzymatic synthesis of c-terminal arylamides of amino acids and peptides. Journal of Organic Chemistry, 74(15), pp. 5145-5150. (doi: 10.1021/jo900634g)

Nuijens, T., Cusan, C., Kruijtzer, J.A.W., Rijkers, D.T.S., Liskamp, R.M.J. and Quaedflieg, P.J.L.M. (2009) Versatile selective α-carboxylic acid esterification of N-protected amino acids and peptides by alcalase. Synthesis, 2009(5), pp. 809-814. (doi: 10.1055/s-0028-1083362)

van Dijk, M., Rijkers, D.T.S., Liskamp, R.M.J. , van Nostrum, C.F. and Hennink, W.E. (2009) Synthesis and applications of biomedical and pharmaceutical polymers via click chemistry methodologies. Bioconjugate Chemistry, 20(11), pp. 2001-2016. (doi: 10.1021/bc900087a)

Yim, C.-B., Boerman, O.C., de Visser, M., de Jong, M., Dechesne, A.C., Rijkers, D.T.S. and Liskamp, R.M.J. (2009) Versatile conjugation of octreotide to dendrimers by cycloaddition (“click”) chemistry to yield high-affinity multivalent cyclic peptide dendrimers. Bioconjugate Chemistry, 20(7), pp. 1323-1331. (doi: 10.1021/bc900052n)

van Ingen, H., van Schaik, F.M.A., Wienk, H., Ballering, J., Rehmann, H., Dechesne, A.C., Kruijzer, J.A.W., Liskamp, R.M.J. , Timmers, H.T.M. and Boelens, R. (2008) Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3. Structure, 16(8), pp. 1245-1256. (doi: 10.1016/j.str.2008.04.015)

Branderhorst, H.M., Ruijtenbeek, R., Liskamp, R.M.J. and Pieters, R.J. (2008) Multivalent carbohydrate recognition on a glycodendrimer‐functionalized flow‐through chip. ChemBioChem, 9(11), pp. 1836-1844. (doi: 10.1002/cbic.200800195)

Özdirekcan, S., Nyholm, T.K.M., Raja, M., Rijkers, D.T.S., Liskamp, R.M.J. and Killian, J.A. (2008) Influence of trifluoroethanol on membrane interfacial anchoring interactions of transmembrane α-helical peptides. Biophysical Journal, 94(4), pp. 1315-1325. (doi: 10.1529/biophysj.106.101782)

Elgersma, R.C., Mulder, G.E., Posthuma, G., Rijkers, D.T.S. and Liskamp, R.M.J. (2008) Mirror image supramolecular helical tapes formed by the enantiomeric-depsipeptide derivatives of the amyloidogenic peptide amylin(20–29). Tetrahedron Letters, 49(6), pp. 987-991. (doi: 10.1016/j.tetlet.2007.12.021)

Kuil, J., van Wandelen, L.T.M., de Mol, N.J. and Liskamp, R.M.J. (2008) A photoswitchable ITAM peptidomimetic: synthesis and real time surface plasmon resonance (SPR) analysis of the effects of cis–trans isomerization on binding. Bioorganic and Medicinal Chemistry, 16(3), pp. 1393-1399. (doi: 10.1016/j.bmc.2007.10.049)

Brouwer, A.J., Elgersma, R.C., Jagodzinska, M., Rijkers, D.T.S. and Liskamp, R.M.J. (2008) Delayed fibril formation of amylin(20–29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis. Bioorganic and Medicinal Chemistry Letters, 18(1), pp. 78-84. (doi: 10.1016/j.bmcl.2007.11.009)

Albada, H.B. and Liskamp, R.M.J. (2008) TAC-scaffolded tripeptides as artificial hydrolytic receptors: a combinatorial approach toward esterase mimics. Journal of Combinatorial Chemistry, 10(6), pp. 814-824. (doi: 10.1021/cc800065a)

Arnusch, C.J., Bonvin, A.M.J.J., Verel, A.M., Jansen, W.T.M., Liskamp, R.M.J. , de Kruijff, B., Pieters, R.J. and Breukink, E. (2008) The vancomycin−nisin(1−12)hybrid restores activity against vancomycin resistant enterococci. Biochemistry, 47(48), pp. 12661-12663. (doi: 10.1021/bi801597b)

Branderhorst, H.M., Kooij, R., Salminen, A., Jongeneel, L.H., Arnusch, C.J., Liskamp, R.M.J. , Finne, J. and Pieters, R.J. (2008) Synthesis of multivalent Streptococcus suis adhesion inhibitors by enzymatic cleavage of polygalacturonic acid and ‘click’ conjugation. Organic and Biomolecular Chemistry, 6, pp. 1425-1434. (doi: 10.1039/b800283e)

Dijk, M.V., Nollet, M.L., Weijers, P., Dechesne, A.C., Nostrum, C.F.V., Hennink, W.E., Rijkers, D.T.S. and Liskamp, R.M.J. (2008) Synthesis and characterization of biodegradable peptide-based polymers prepared by microwave-assisted click chemistry. Biomacromolecules, 9(10), pp. 2834-2843. (doi: 10.1021/bm8005984)

Martin, N.I. and Liskamp, R.M.J. (2008) Preparation ofNG-substitutedl-arginine analogues suitable for solid phase peptide synthesis. Journal of Organic Chemistry, 73(19), pp. 7849-7851. (doi: 10.1021/jo801517f)

Pieters, R. and Liskamp, R.M.J. (2008) Multivalent presentation strategies in novel inhibitors of bacterial (toxin) adhesion and synthetic vaccines. Anti-Infective Agents in Medicinal Chemistry, 7(3), pp. 193-200. (doi: 10.2174/187152108784911269)

Pieters, R.J., Rijkers, D.T.S. and Liskamp, R.M.J. (2007) Application of the 1,3-dipolar cycloaddition reaction in chemical biology: approaches toward multivalent carbohydrates and peptides and peptide-based polymers. QSAR & Combinatorial Science, 26(11-12), pp. 1181-1190. (doi: 10.1002/qsar.200740075)

Arnusch, C.J., Branderhorst, H., de Kruijff, B., Liskamp, R.M.J. , Breukink, E. and Pieters, R.J. (2007) Enhanced membrane pore formation by multimeric/oligomeric antimicrobial peptides. Biochemistry, 46(46), pp. 13437-13442. (doi: 10.1021/bi7015553)

Brouwer, A.J., Bunschoten, A. and Liskamp, R.M.J. (2007) Synthesis and evaluation of chloromethyl sulfoxides as a new class of selective irreversible cysteine protease inhibitors. Bioorganic and Medicinal Chemistry Letters, 15(22), pp. 6985-6993. (doi: 10.1016/j.bmc.2007.07.045)

van Zoelen, D.-J., Egmond, M.R., Pieters, R.J. and Liskamp, R.M.J. (2007) Synthesis and evaluation of TAC-based inhibitors of papain as mimics of cystatin B. ChemBioChem, 8(16), pp. 1950-1956. (doi: 10.1002/cbic.200700243)

Elgersma, R.C., Posthuma, G., Rijkers, D.T.S. and Liskamp, R.M.J. (2007) Backbone-modified amylin derivatives: implications for amyloid inhibitor design and as template for self-assembling bionanomaterials. Journal of Peptide Science, 13(11), pp. 709-716. (doi: 10.1002/psc.831)

Hijnen, M., van Zoelen, D.J., Chamorro, C., van Gageldonk, P., Mooi, F.R., Berbers, G. and Liskamp, R.M.J. (2007) A novel strategy to mimic discontinuous protective epitopes using a synthetic scaffold. Vaccine, 25(37-38), pp. 6807-6817. (doi: 10.1016/j.vaccine.2007.06.027)

Ghalit, N., Reichwein, J.F., Hilbers, H.W., Breukink, E., Rijkers, D.T.S. and Liskamp, R.S.J. (2007) Synthesis of bicyclic alkene-/alkane-bridged nisin mimics by ring-closing metathesis and their biochemical evaluation as lipid II binders: toward the design of potential novel antibiotics. ChemBioChem, 8(13), pp. 1540-1554. (doi: 10.1002/cbic.200700244)

Pukin, A.V., Branderhorst, H.M., Sisu, C., Weijers, C.A.G.M., Gilbert, M., Liskamp, R.M.J. , Visser, G.M., Zuilhof, H. and Pieters, R.J. (2007) Strong inhibition of cholera toxin by multivalent GM1 derivatives. ChemBioChem, 8(13), pp. 1500-1503. (doi: 10.1002/cbic.200700266)

Elgersma, R.C., Mulder, G.E., Kruijtzer, J.A.W., Posthuma, G., Rijkers, D.T.S. and Liskamp, R.M.J. (2007) Transformation of the amyloidogenic peptide amylin(20–29) into its corresponding peptoid and retropeptoid: Access to both an amyloid inhibitor and template for self-assembled supramolecular tapes. Bioorganic and Medicinal Chemistry Letters, 17(7), pp. 1837-1842. (doi: 10.1016/j.bmcl.2007.01.042)

Dijkgraaf, I., Liu, S., Kruijtzer, J.A.W., Soede, A.C., Oyen, W.J.G., Liskamp, R.M.J. , Corstens, F.H.M. and Boerman, O.C. (2007) Effects of linker variation on the in vitro and in vivo characteristics of an 111In-labeled RGD peptide. Nuclear Medicine and Biology, 34(1), pp. 29-35. (doi: 10.1016/j.nucmedbio.2006.10.006)

Albada, H.B., Soulimani, F., Weckhuysen, B.M. and Liskamp, R.M.J. (2007) Scaffolded amino acids as a close structural mimic of type-3 copper binding sites. Chemical Communications, 2007(46), pp. 4895-4897. (doi: 10.1039/b709400k)

Branderhorst, H.M., Liskamp, R.M.J. and Pieters, R.J. (2007) Solid-phase carbohydrate synthesis via on-bead protecting group chemistry. Tetrahedron, 63(20), pp. 4290-4296. (doi: 10.1016/j.tet.2007.03.051)

Branderhorst, H.M., Liskamp, R.M.J. , Visser, G.M. and Pieters, R.J. (2007) Strong inhibition of cholera toxin binding by galactose dendrimers. Chemical Communications, 2007(47), pp. 5043-5045. (doi: 10.1039/b711070g)

de Planque, M.R.R., Raussens, V., Contera, S.A., Rijkers, D.T.S., Liskamp, R.J. , Ruysschaert, J.-M., Ryan, J.F., Separovic, F. and Watts, A. (2007) β-sheet structured β-amyloid(1-40) perturbs phosphatidylcholine model membranes. Journal of Molecular Biology, 368(4), pp. 982-997. (doi: 10.1016/j.jmb.2007.02.063)

Dijkgraaf, I., Kruijtzer, J.A.W., Liu, S., Soede, A.C., Oyen, W.J.G., Corstens, F.H.M., Liskamp, R.M.J. and Boerman, O.C. (2007) Improved targeting of the αvβ3 integrin by multimerisation of RGD peptides. European Journal of Nuclear Medicine and Molecular Imaging, 34(2), pp. 267-273. (doi: 10.1007/s00259-006-0180-9)

Dijkgraaf, I., Rijnders, A.Y., Soede, A., Dechesne, A.C., van Esse, G.W., Brouwer, A., Corstens, F.H.M., Boerman, O.C., Rijkers, D.T.S. and Liskamp, R.M.J. (2007) Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes. Organic and Biomolecular Chemistry, 5(6), pp. 935-944. (doi: 10.1039/b615940k)

Ghalit, N., Kemmink, J., Hilbers, H.W., Versluis, C., Rijkers, D.T.S. and Liskamp, R.M.J. (2007) Step-wise and pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis. Organic and Biomolecular Chemistry, 5, pp. 924-934. (doi: 10.1039/b618085j)

Merkx, R., van Haren, M.J., Rijkers, D.T.S. and Liskamp, R.M.J. (2007) Resin-bound sulfonyl azides: efficient loading and activation strategy for the preparation of theN-Acyl sulfonamide linker. Journal of Organic Chemistry, 72(12), pp. 4574-4577. (doi: 10.1021/jo0704513)

van Dijk, M., Mustafa, K., Dechesne, A.C., van Nostrum, C.F., Hennink, W.E., Rijkers, D.T.S. and Liskamp, R.M.J. (2007) Synthesis of peptide-based polymers by microwave-assisted cycloaddition backbone polymerization. Biomacromolecules, 8(2), pp. 327-330. (doi: 10.1021/bm061010g)

Poot, A.J., Ruijter, E., Nuijens, T., Dirksen, E.H.C., Heck, A.J.R., Slijper, M., Rijkers, D.T.S. and Liskamp, R.M.J. (2006) Selective enrichment of ser-/thr-phosphorylated peptides in the presence of ser-/thr-glycosylated peptides. Proteomics, 6(24), pp. 6394-6399. (doi: 10.1002/pmic.200600373)

Dijkgraaf, I., Kruijtzer, J.A.W., Frielink, C., Soede, A.C., Hilbers, H.W., Oyen, W.J.G., Corstens, F.H.M., Liskamp, R.M.J. and Boerman, O.C. (2006) Synthesis and biological evaluation of potent αvβ3-integrin receptor antagonists. Nuclear Medicine and Biology, 33(8), pp. 953-961. (doi: 10.1016/j.nucmedbio.2006.08.008)

van Scherpenzeel, M., van der Pot, M., Arnusch, C.J., Liskamp, R.M.J. and Pieters, R.J. (2006) Detection of galectin-3 by novel peptidic photoprobes. Bioorganic and Medicinal Chemistry Letters, 17(2), pp. 376-378. (doi: 10.1016/j.bmcl.2006.10.043)

Ghalit, N., Rijkers, D.T.S. and Liskamp, R.M.J. (2006) Alkene- and alkyne-bridged mimics of nisin as potential peptide-based antibiotics. Journal of Molecular Catalysis A: Chemical, 254(1-2), pp. 68-77. (doi: 10.1016/j.molcata.2006.03.029)

Elgersma, R.C., Meijneke, T., Posthuma, G., Rijkers, D.T.S. and Liskamp, R.M.J. (2006) Self-Assembly of amylin(20–29) amide-bond derivatives into helical ribbons and peptide nanotubes rather than fibrils. Chemistry: A European Journal, 12(14), pp. 3714-3725. (doi: 10.1002/chem.200501374)

Engel, M.F.M., Yigittop, H., Elgersma, R.C., Rijkers, D.T.S., Liskamp, R.M.J. , de Kruijff, B., Höppener, J.W.M. and Antoinette Killian, J. (2006) Islet amyloid polypeptide inserts into phospholipid monolayers as monomer. Journal of Molecular Biology, 356(3), pp. 783-789. (doi: 10.1016/j.jmb.2005.12.020)

Dijkgraaf, I., Kruijtzer, J.A.W., Frielink, C., Corstens, F.H.M., Oyen, W.J.G., Liskamp, R.M.J. and Boerman, O.C. (2006) αvβ3 integrin-targeting of intraperitoneally growing tumors with a radiolabeled RGD peptide. International Journal of Cancer, 120(3), pp. 605-610. (doi: 10.1002/ijc.22297)

Ballell, L., van Scherpenzeel, M., Buchalova, K., Liskamp, R.M.J. and Pieters, R.J. (2006) A new chemical probe for the detection of the cancer-linked galectin-3. Organic and Biomolecular Chemistry, 4, pp. 4387-4394. (doi: 10.1039/b611050a)

Dirksen, E.H.C., Pinkse, M.W.H., Rijkers, D.T.S., Cloos, J., Liskamp, R.M.J. , Slijper, M. and Heck, A.J.R. (2006) Investigating the dynamic nature of the interactions between nuclear proteins and histones upon DNA damage using an immobilized peptide chemical proteomics approach. Journal of Proteome Research, 5(9), pp. 2380-2388. (doi: 10.1021/pr060278b)

Elgersma, R.C., Meijneke, T., de Jong, R., Brouwer, A.J., Posthuma, G., Rijkers, D.T.S. and Liskamp, R.M.J. (2006) Synthesis and structural investigations of N-alkylated ?-peptidosulfonamide?peptide hybrids of the amyloidogenic amylin(20?29) sequence: implications of supramolecular folding for the design of peptide-based bionanomaterials. Organic and Biomolecular Chemistry, 4, pp. 3587-3597. (doi: 10.1039/b606875h)

Liskamp, R.M.J. , Brouwer, A.J., Merkx, R., Dabrowska, K. and Rijkers, D.T. (2006) Synthesis and applications of β-aminoethanesulfonyl azides. Synthesis, 3, pp. 455-460. (doi: 10.1055/s-2006-926273)

ten Brink, H.T., Rijkers, D.T.S. and Liskamp, R.M.J. (2006) Synthesis of alkyne-bridged cyclic tripeptides toward constrained mimics of vancomycin. Journal of Organic Chemistry, 71(5), pp. 1817-1824. (doi: 10.1021/jo051933m)

de Mol, N.J., Catalina, M.I., Dekker, F.J., Fischer, M.J.E., Heck, A.J.R. and Liskamp, R.M.J. (2005) Protein flexibility and ligand rigidity: a thermodynamic and kinetic study of ITAM-based ligand binding to Syk tandem SH2. ChemBioChem, 6(12), pp. 2261-2270. (doi: 10.1002/cbic.200500141)

van der Veken, P., Dirksen, E.H.C., Ruijter, E., Elgersma, R.C., Heck, A.J.R., Rijkers, D.T.S., Slijper, M. and Liskamp, R.M.J. (2005) Development of a novel chemical probe for the selective enrichment of phosphorylated serine- and threonine-containing peptides. ChemBioChem, 6(12), pp. 2271-2280. (doi: 10.1002/cbic.200500209)

Haas, P.-J. et al. (2005) The structure of the C5a receptor-blocking domain of chemotaxis inhibitory protein of staphylococcus aureus is related to a group of immune evasive molecules. Journal of Molecular Biology, 353(4), pp. 859-872. (doi: 10.1016/j.jmb.2005.09.014)

Autar, R., Liskamp, R.M.J. and Pieters, R. (2005) A facile synthesis of the GalNAcβ1→4Gal target sequence of respiratory pathogens. Carbohydrate Research, 340(15), pp. 2436-2442. (doi: 10.1016/j.carres.2005.08.001)

Joosten, J.A.F., Tholen, N.T.H., Ait El Maate, F., Brouwer, A.J., van Esse, G.W., Rijkers, D.T.S., Liskamp, R.M.J. and Pieters, R.J. (2005) High-yielding microwave-assisted synthesis of triazole-linked glycodendrimers by copper-catalyzed [3+2] cycloaddition. European Journal of Organic Chemistry, 2005(15), pp. 3182-3185. (doi: 10.1002/ejoc.200500216)

Catalina, M.I., Fischer, M.J.E., Dekker, F.J., Liskamp, R.M.J. and Heck, A.J.R. (2005) Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study. Journal of the American Society for Mass Spectrometry, 16(7), pp. 1039-1051. (doi: 10.1016/j.jasms.2005.02.011)

Wels, B., Kruijtzer, J.A.W., Garner, K., Nijenhuis, W.A.J., Gispen, W.H., Adan, R.A.H. and Liskamp, R.M.J. (2005) Synthesis of a novel potent cyclic peptide MC4-ligand by ring-closing metathesis. Bioorganic and Medicinal Chemistry, 13(13), pp. 4221-4227. (doi: 10.1016/j.bmc.2005.04.027)

Rijkers, D.T.S., Kruijtzer, J.A.W., Killian, J.A. and Liskamp, R.M.J. (2005) A convenient solid phase synthesis of S-palmitoyl transmembrane peptides. Tetrahedron Letters, 46(19), pp. 3341-3345. (doi: 10.1016/j.tetlet.2005.03.079)

Brouwer, A.J. and Liskamp, R.M.J. (2005) Synthesis of novel dendrimeric systems containing NLO ligands. European Journal of Organic Chemistry, 2005(3), pp. 487-495. (doi: 10.1002/ejoc.200400609)

de Haan, E.C., Moret, E.D., Wagenaar-Hilbers, J.P.A., Liskamp, R.M.J. and Wauben, M.H.M. (2005) Possibilities and limitations in the rational design of modified peptides for T cell mediated immunotherapy. Molecular Immunology, 42(3), pp. 365-373. (doi: 10.1016/j.molimm.2004.07.015)

de Haan, E.C., Wagenaar-Hilbers, J.P.A., Liskamp, R.M.J. , Moret, E.D. and Wauben, M.H.M. (2005) Limited plasticity in T cell recognition of modified T cell receptor contact residues in MHC class II bound peptides. Molecular Immunology, 42(3), pp. 355-364. (doi: 10.1016/j.molimm.2004.07.044)

Kasyanov, V. et al. (2005) Tannic acid mimicking dendrimers as small intestine submucosa stabilizing nanomordants. Biomaterials, 27(5), pp. 745-751. (doi: 10.1016/j.biomaterials.2005.06.022)

Appeldoorn, C.C.M., Joosten, J.A.F., Ait el Maate, F., Dobrindt, U., Hacker, J., Liskamp, R.M.J. , Khan, A.S. and Pieters, R.J. (2005) Novel multivalent mannose compounds and their inhibition of the adhesion of type 1 fimbriated uropathogenic E. coli. Tetrahedron: Asymmetry, 16(2), pp. 361-372. (doi: 10.1016/j.tetasy.2004.11.014)

Wels, B., Kruijtzer, J.A.W., Garner, K.M., Adan, R.A.H. and Liskamp, R.M.J. (2005) Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups. Bioorganic and Medicinal Chemistry Letters, 15(2), pp. 287-290. (doi: 10.1016/j.bmcl.2004.10.082)

van Leeuwen, S.H., Quaedflieg, P.J.L.M., Broxterman, Q.B., Milhajlovic, Y. and Liskamp, R.M.J. (2005) The synthesis of amides and dipeptides from unprotected amino acids by a simultaneous protection–activation strategy using boron trifluoride diethyl etherate. Tetrahedron Letters, 46(4), pp. 653-656. (doi: 10.1016/j.tetlet.2004.11.129)

Broekema, M., van Eerd, J.J.E.M., Oyen, W.J.G., Corstens, F.H.M., Liskamp, R.M.J. , Boerman, O.C. and Harris, T.D. (2005) Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci. Journal of Medicinal Chemistry, 48(20), pp. 6442-6453. (doi: 10.1021/jm050383h)

de Mol, N.J., Dekker, F.J., Broutin, I., Fischer, M.J.E. and Liskamp, R.M.J. (2005) Surface plasmon resonance thermodynamic and kinetic analysis as a strategic tool in drug design. Distinct ways for phosphopeptides to plug into Src- and Grb2 SH2 domains. Journal of Medicinal Chemistry, 48(3), pp. 753-763. (doi: 10.1021/jm049359e)

Ghalit, N.,, Rijkers, D.T.S., Kemmink, J., Versluis, C. and Liskamp, R.M.J. (2005) Pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis. Chemical Communications(2), pp. 192-194. (doi: 10.1039/b415555f)

Ghalit, N., Poot, A.J., Fürstner, A., Rijkers, D.T.S. and Liskamp, R.M.J. (2005) Ring-closing alkyne metathesis approach toward the synthesis of alkyne mimics of thioether A-, B-, C-, and DE-ring systems of the lantibiotic nisin Z. Organic Letters, 7(14), pp. 2961-2964. (doi: 10.1021/ol0508781)

Kruijtzer, J.A.W., Nijenhuis, W.A.J., Wanders, N., Gispen, W.H., Liskamp, R.M.J. and Adan, R.A.H. (2005) Peptoid−peptide hybrids as potent novel melanocortin receptor ligands. Journal of Medicinal Chemistry, 48(13), pp. 4224-4230. (doi: 10.1021/jm0490033)

Merkx, R., Brouwer, A.J., Rijkers, D.T.S. and Liskamp, R.M.J. (2005) Highly efficient coupling of β-substituted aminoethane sulfonyl azides with thio acids, toward a new chemical ligation reaction. Organic Letters, 7(6), pp. 1125-1128. (doi: 10.1021/ol0501119)

Özdirekcan, S., Rijkers, D.T.S., Liskamp, R.M.J. and Killian, J.A. (2005) Influence of flanking residues on tilt and rotation angles of transmembrane peptides in lipid bilayers. A solid-state2H NMR study. Biochemistry, 44(3), pp. 1004-1012. (doi: 10.1021/bi0481242)

Rijkers, D.T.S., van Esse, G.W., Merkx, R., Brouwer, A.J., Jacobs, H.J.F., Pieters, R.J. and Liskamp, R.M.J. (2005) Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry. Chemical Communications(36), pp. 4581-4583. (doi: 10.1039/b507975f)

van Meer, G. and Liskamp, R.M.J. (2005) Brilliant lipids. Nature Methods, 2(1), pp. 14-15. (doi: 10.1038/nmeth0105-14)

Chamorro, C. and Liskamp, R.M.J. (2004) Selection of synthetic receptors capable of sensing the difference in binding of d-Ala-d-Ala or d-Ala-d-Lac ligands by screening of a combinatorial CTV-based library. Tetrahedron, 60(49), pp. 11145-11157. (doi: 10.1016/j.tet.2004.08.074)

Haas, P.-J., de Haas, C.J.C., Kleibeuker, W., Poppelier, M.J.J.G., van Kessel, K.P.M., Kruijtzer, J.A.W., Liskamp, R.M.J. and van Strijp, J.A.G. (2004) N-terminal residues of the chemotaxis inhibitory protein of Staphylococcus aureus are essential for blocking formylated peptide receptor but not C5a receptor. Journal of Immunology, 173(9), pp. 5704-11.

de Planque, M.R.R., Rijkers, D.T.S., Fletcher, J.I., Liskamp, R.M.J. and Separovic, F. (2004) The αM1 segment of the nicotinic acetylcholine receptor exhibits conformational flexibility in a membrane environment. Biochimica et Biophysica Acta: Biomembranes, 1665(1-2), pp. 40-47. (doi: 10.1016/j.bbamem.2004.06.021)

Rijkers, D.T.S., den Hartog, J.A.J. and Liskamp, R.M.J. (2004) Synthesis and biological activity of N-terminal lipidated and/or fluorescently labeled conjugates of astressin as corticotropin releasing factor antagonists. Bioorganic and Medicinal Chemistry, 12(19), pp. 5099-5106. (doi: 10.1016/j.bmc.2004.07.035)

Monnee, M.C.F., Brouwer, A.J. and Liskamp, R.M.J. (2004) Synthesis, screening and evaluation of a combined library of tweezer- and tripodal synthetic receptors. QSAR & Combinatorial Science, 23(7), pp. 546-559. (doi: 10.1002/qsar.200420019)

Wang, X., Permentier, H.P., Rink, R., Kruijtzer, J.A.W., Liskamp, R.M.J. , Wösten, H.A.B., Poolman, B. and Robillard, G.T. (2004) Probing the self-assembly and the accompanying structural changes of hydrophobin SC3 on a hydrophobic surface by mass spectrometry. Biophysical Journal, 87(3), pp. 1919-1928. (doi: 10.1529/biophysj.104.041616)

Nijenhuis, W.A.J., Wanders, N., Kruijtzer, J.A.W., Liskamp, R.M. , Gispen, W.H. and Adan, R.A.H. (2004) Accelerating sensory recovery after sciatic nerve crush: non-selective versus melanocortin MC4 receptor-selective peptides. European Journal of Pharmacology, 495(2-3), pp. 145-152. (doi: 10.1016/j.ejphar.2004.05.037)

Liskamp, R.M.J. and Kruijtzer, J.A.W. (2004) Peptide transformation leading to peptide-peptidosulfonamide hybrids and oligo peptidosulfonamides. Molecular Diversity, 8(2), pp. 79-87. (doi: 10.1023/B:MODI.0000025651.88080.9d)

Strandberg, E., Özdirekcan, S., Rijkers, D.T.S., van der Wel, P.C.A., Koeppe, R.E., Liskamp, R.M.J. and Antoinette Killian, J. (2004) Tilt angles of transmembrane model peptides in oriented and non-oriented lipid bilayers as determined by 2H solid-state NMR. Biophysical Journal, 86(6), pp. 3709-3721. (doi: 10.1529/biophysj.103.035402)

Rijkers, D.T.S., Kruijtzer, J.A.W., van Oostenbrugge, M., Ronken, E., den Hartog, J.A.J. and Liskamp, R.M.J. (2004) Structure-activity studies on the corticotropin releasing factor antagonist astressin, leading to a minimal sequence necessary for antagonistic activity. ChemBioChem, 5(3), pp. 340-348. (doi: 10.1002/cbic.200300769)

de Planque, M.R.R., Rijkers, D.T.S., Liskamp, R.M.J. and Separovic, F. (2004) TheαM1 transmembrane segment of the nicotinic acetylcholine receptor interacts strongly with model membranes. Magnetic Resonance in Chemistry, 42(2), pp. 148-154. (doi: 10.1002/mrc.1326)

Arosio, D., Vrasidas, I., Valentini, P., Liskamp, R.M.J. , Pieters, R.J. and Bernardi, A. (2004) Synthesis and cholera toxin binding properties of multivalent GM1 mimicsElectronic supplementary information (ESI) available: characterization of the polyvalent compounds ? imide by-products. See http://www.rsc.org/suppdata/ob/b4/b405344c/. Organic and Biomolecular Chemistry, 2(14), p. 2113. (doi: 10.1039/b405344c)

Ballell, L., Alink, K.J., Slijper, M., Versluis, C., Liskamp, R.M.J. and Pieters, R.J. (2004) A new chemical probe for proteomics of carbohydrate-binding proteins. ChemBioChem, 6(2), pp. 291-295. (doi: 10.1002/cbic.200400209)

Ballell, L., Joosten, J.A.F., Maate, F.A.e., Liskamp, R.M.J. and Pieters, R.J. (2004) Microwave-assisted, tin-mediated, regioselective 3-O-alkylation of galactosides. Tetrahedron Letters, 45(35), pp. 6685-6687. (doi: 10.1016/j.tetlet.2004.06.113)

Chamorro, C., Hofman, J.-W. and Liskamp, R.M.J. (2004) Combinatorial solid-phase synthesis and screening of a diverse tripodal triazacyclophane (TAC)-based synthetic receptor library showing a remarkable selectivity towards a d-Ala-d-Ala containing ligand. Tetrahedron, 60(39), pp. 8691-8697. (doi: 10.1016/j.tet.2004.05.121)

Dehaan, E., Wauben, M., Wagenaarhilbers, J., Grosfeldstulemeyer, M., Rijkers, D., Moret, E. and Liskamp, R.M.J. (2004) Stabilization of peptide guinea pig myelin basic protein 72-85 by N-terminal acetylation - implications for immunological studies. Molecular Immunology, 40(13), pp. 943-948. (doi: 10.1016/j.molimm.2003.10.015)

Joosten, J.A.F., Loimaranta, V., Appeldoorn, C.C.M., Haataja, S., El Maate, F.., Liskamp, R.M.J. , Finne, J. and Pieters, R.J. (2004) Inhibition of Streptococcus suis adhesion by dendritic galabiose compounds at low nanomolar concentration. Journal of Medicinal Chemistry, 47(26), pp. 6499-6508. (doi: 10.1021/jm049476+)

Ridder, A.N.J.A., Spelbrink, R.E.J., Demmers, J.A.A., Rijkers, D.T.S., Liskamp, R.M.J. , Brunner, J., Heck, A.J.R., de Kruijff, B. and Killian, J.A. (2004) Photo-crosslinking analysis of preferential interactions between a transmembrane peptide and matching lipids. Biochemistry, 43(15), pp. 4482-4489. (doi: 10.1021/bi049899d)

ten Brink, H.T., Rijkers, D.T.S., Kemmink, J., Hilbers, H.W. and Liskamp, R.M.J. (2004) Ring-closing metathesis for the synthesis of side chain knotted pentapeptides inspired by vancomycin. Organic and Biomolecular Chemistry, 2(18), pp. 2658-2663. (doi: 10.1039/b408820d)

Autar, R., Khan, A.S., Schad, M., Hacker, J., Liskamp, R.M.J. and Pieters, R.J. (2003) Adhesion inhibition of F1C-fimbriated escherichia coli and pseudomonas aeruginosa PAK and PAO by multivalent carbohydrate ligands. ChemBioChem, 4(12), pp. 1317-1325. (doi: 10.1002/cbic.200300719)

Catalina, M.I., Dekker, F.J., Liskamp, R.M.J. , Versluis, C., Maier, C.S. and Heck, A.J.R. (2003) Structural analysis of high affinity divalent phosphopeptide hybrids of spleen tyrosine kinase. International Journal of Mass Spectrometry, 228(2-3), pp. 879-890. (doi: 10.1016/S1387-3806(03)00190-8)

Dekker, F.J., de Mol, N.J., Fischer, M.J.E. and Liskamp, R.M.J. (2003) Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the syk SH2 domains with equally high affinity as the natural ligand. Bioorganic and Medicinal Chemistry Letters, 13(7), pp. 1241-1244. (doi: 10.1016/S0960-894X(03)00117-3)

Dekker, F.J., de Mol, N.J., Bultinck, P., Kemmink, J., Hilbers, H.W. and Liskamp, R.M.J. (2003) Role of solution conformation and flexibility of short peptide ligands that bind to the p56^lck SH2 domain. Bioorganic and Medicinal Chemistry, 11(6), pp. 941-949. (doi: 10.1016/S0968-0896(02)00536-9)

Nijenhuis, W.A.J., Kruijtzer, J.A.W., Wanders, N., Vrinten, D.H., Garner, K.M., Schaaper, W.M.M., Meloen, R.H., Gispen, W.H., Liskamp, R.M.J. and Adan, R.A.H. (2003) Discovery and in vivo evaluation of new melanocortin-4 receptor-selective peptides. Peptides, 24(2), pp. 271-280. (doi: 10.1016/S0196-9781(03)00032-9)

Ameijde, J. v. and Liskamp, R.M.J. (2003) Synthesis of novel trivalent amino acid glycoconjugates based on the cyclotriveratrylene ('CTV') scaffold. Organic and Biomolecular Chemistry, 1(15), pp. 2661-2669. (doi: 10.1039/b303795a)

Chamorro, C. and Liskamp, R.M.J. (2003) Approaches to the solid phase of a cyclotriveratrylene scaffold-based tripodal library as potential artificial receptors. Journal of Combinatorial Chemistry, 5(6), pp. 794-801. (doi: 10.1021/cc034003u)

Dekker, F.J., de Mol, N.J., Fischer, M.J.E., Kemmink, J. and Liskamp, R.M.J. (2003) Cyclic phosphopeptides for interference with Grb2 SH2 domain signal transduction prepared by ring-closing metathesis and phosphorylation. Organic and Biomolecular Chemistry, 1(19), pp. 3297-3303. (doi: 10.1039/b306681a)

Merkx, R., Rijkers, D.T.S., Kemmink, J. and Liskamp, R.M.J. (2003) Chemoselective coupling of peptide fragments using the Staudinger ligation. Tetrahedron Letters, 44(24), pp. 4515-4518. (doi: 10.1016/S0040-4039(03)01014-1)

Vrasidas, I., André, S., Valentini, P., Böck, C., Lensch, M., Kaltner, H., Liskamp, R.M.J. , Gabius, H.-J. and Pieters, R.J. (2003) Rigidified multivalent lactose molecules and their interactions with mammalian galectins: a route to selective inhibitors. Organic and Biomolecular Chemistry, 1(5), pp. 803-810. (doi: 10.1039/b210923a)

van Leeuwen, S.H., Quaedflieg, P.J.L.M., Broxterman, Q.B. and Liskamp, R.M.J. (2002) Synthesis of amides from unprotected amino acids by a simultaneous protection–activation strategy using dichlorodialkyl silanes. Tetrahedron Letters, 43(50), pp. 9203-9207. (doi: 10.1016/S0040-4039(02)02275-X)

de Jong, R., Rijkers, D.T.S. and Liskamp, R.M.J. (2002) Automated solid-phase synthesis and structural investigation of -peptidosulfonamides and -peptidosulfonamide/-peptide hybrids: -peptidosulfonamide and -peptide foldamers are two of a different kind. Helvetica Chimica Acta, 85(12), pp. 4230-4243. (doi: 10.1002/hlca.200290008)

Rump, E.T., Rijkers, D.T.S., Hilbers, H.W., de Groot, P.G. and Liskamp, R.M.J. (2002) Cyclotriveratrylene (CTV) as a new chiral triacid scaffold capable of inducing triple helix formation of collagen peptides containing either a native sequence or pro-hyp-gly repeats. Chemistry: A European Journal, 8(20), pp. 4613-4621. (doi: 10.1002/1521-3765(20021018)8:20<4613::AID-CHEM4613>3.0.CO;2-R)

Rijkers, D.T.S., Höppener, J.W.M., Posthuma, G., Lips, C.J.M. and Liskamp, R.M.J. (2002) Inhibition of amyloid fibril formation of human amylin by N-alkylated amino acid and -hydroxy acid residue containing peptides. Chemistry: A European Journal, 8(18), pp. 4285-4291. (doi: 10.1002/1521-3765(20020916)8:18<4285::AID-CHEM4285>3.0.CO;2-0)

Halkes, S.B.A., Vrasidas, I., Rooijer, G.R., van den Berg, A.J.J., Liskamp, R.M.J. and Pieters, R. (2002) Synthesis and biological activity of polygalloyl-dendrimers as stable tannic acid mimics. Bioorganic and Medicinal Chemistry Letters, 12(12), pp. 1567-1570. (doi: 10.1016/S0960-894X(02)00245-7)

Rijkers, D.T.S., van Vugt, H.H.R., Jacobs, H.J.F. and Liskamp, R.M.J. (2002) A convenient synthesis of azido peptides by post-assembly diazo transfer on the solid phase applicable to large peptides. Tetrahedron Letters, 43(20), pp. 3657-3660. (doi: 10.1016/S0040-4039(02)00629-9)

Dekker, F.J., de Mol, N.J., van Ameijde, J., Fischer, M.J.E., Ruijtenbeek, R., Redegeld, F.A.M. and Liskamp, R.M.J. (2002) Replacement of the intervening amino acid sequence of a Syk-binding diphosphopeptide by a nonpeptide spacer with preservation of high affinity. ChemBioChem, 3(2-3), pp. 238-242. (doi: 10.1002/1439-7633(20020301)3:2/3<238::AID-CBIC238>3.0.CO;2-W)

Rijkers, D.T.S., den Hartog, J.A.J. and Liskamp, R.M.J. (2002) An optimized solid phase synthesis strategy- including on-resin lactamization?of astressin, its retro-, inverso-, and retro-inverso isomers as corticotropin releasing factor antagonists. Biopolymers, 63(2), pp. 141-149. (doi: 10.1002/bip.10052)

Ruijtenbeek, R., Versluis, C., Heck, A.J.R., Redegeld, F.A.M., Nijkamp, F.P. and Liskamp, R.M.J. (2002) Characterization of a phosphorylated peptide and peptoid and peptoid-peptide hybrids by mass spectrometry. Journal of Mass Spectrometry, 37(1), pp. 47-55. (doi: 10.1002/jms.245)

Branderhorst, H.M., Kemmink, J., Liskamp, R.M.J. and Pieters, R.J. (2002) Catalytic conversions of diazosugars. Tetrahedron Letters, 43(52), pp. 9601-9603. (doi: 10.1016/S0040-4039(02)02407-3)

Opatz, T. and Liskamp, R.M.J. (2002) Synthesis and screening of libraries of synthetic tripodal receptor molecules with three different amino acid or peptide arms: identification of iron binders. ACS Combinatorial Science, 4(4), pp. 275-284. (doi: 10.1021/cc020009s)

Strandberg, E., Morein, S., Rijkers, D.T.S., Liskamp, R.M.J. , van der Wel, P.C.A. and Killian, J.A. (2002) Lipid dependence of membrane anchoring properties and snorkeling behavior of aromatic and charged residues in transmembrane peptides. Biochemistry, 41(23), pp. 7190-7198. (doi: 10.1021/bi012047i)

Vrasidas, I., Kemmink, J., Liskamp, R.M.J. and Pieters, R. J. (2002) Synthesis and cholera toxin binding properties of a lactose-2-aminothiazoline conjugate. Organic Letters, 4(10), pp. 1807-1808. (doi: 10.1021/ol025909w)

Wels, B., Kruijtzer, J.A.W. and Liskamp, R.M.J. (2002) Synthesis of cyclic (α2β)-tripeptides as potential peptide turn mimetics. Organic Letters, 4(13), pp. 2173-2176. (doi: 10.1021/ol025988b)

Monnee, M.C.F., Brouwer, A.J., Verbeek, L.M., van Wageningen, A.M.A. and Liskamp, R.M.J. (2001) Bio-inspired synthetic receptor molecules towards mimicry of vancomycin. Bioorganic and Medicinal Chemistry Letters, 11(12), pp. 1521-1525. (doi: 10.1016/S0960-894X(01)00237-2)

Ruijtenbeek, R., Kruijtzer, J.A., van de Wiel, W., Fischer, M.J., Flück, M., Redegeld, F.A., Liskamp, R.M.J. and Nijkamp, F.P. (2001) Peptoid - peptide hybrids that bind Syk SH2 domains involved in signal transduction. ChemBioChem, 2(3), pp. 171-9. (doi: 10.1002/1439-7633(20010302)2:3<171::AID-CBIC171>3.0.CO;2-B)

Monnee, M.C.F., Marijne, M.F., Brouwer, A.J. and Liskamp, R.M.J. (2001) Erratum to "A practical solid phase synthesis of oligopeptidosulfonamide foldamers"[Tetrahedron Letters 41 (2000) 7991–7995]. Tetrahedron Letters, 42(5), p. 965. (doi: 10.1016/S0040-4039(00)02112-2)

Boeijen, A., van Ameijde, J. and Liskamp, R.M.J. (2001) Solid-phase synthesis of oligourea peptidomimetics employing the Fmoc protection strategy. Journal of Organic Chemistry, 66(25), pp. 8454-8462. (doi: 10.1021/jo010656q)

de Planque, M.R.R., Goormaghtigh, E., Greathouse, D.V., Koeppe, R.E., Kruijtzer, J.A.W., Liskamp, R.M.J. , de Kruijff, B. and Killian, J.A. (2001) Sensitivity of single membrane-spanning α-helical peptides to hydrophobic mismatch with a lipid bilayer: effects on backbone structure, orientation, and extent of membrane incorporation. Biochemistry, 40(16), pp. 5000-5010. (doi: 10.1021/bi000804r)

Opatz, T. and Liskamp, R.M.J. (2001) A electively deprotectable triazacyclophane scaffold for the construction of artificial receptors. Organic Letters, 3(22), pp. 3499-3502. (doi: 10.1021/ol0101741)

Reichwein, J.F., Versluis, C. and Liskamp, R.M.J. (2000) Synthesis of cyclic peptides by ring-closing metathesis. Journal of Organic Chemistry, 65(19), pp. 6187-6195. (doi: 10.1021/jo000759t)

Brouwer, A.J., van der Linden, H.J. and Liskamp, R.M.J. (2000) Combinatorial chemistry for ligand development in catalysis: synthesis and catalysis screening of peptidosulfonamide tweezers on the solid phase. Journal of Organic Chemistry, 65(6), pp. 1750-1757. (doi: 10.1021/jo991628z)

van Ameijde, J. and Liskamp, R.M.J. (2000) Peptidomimetic building blocks for the synthesis of sulfonamide peptoids. Tetrahedron Letters, 41(7), pp. 1103-1106. (doi: 10.1016/S0040-4039(99)02240-6)