Professor Will Fuller

Professor of Molecular Physiology (Cardiovascular & Metabolic Health)

telephone: 0141 330 3228
email: Will.Fuller@glasgow.ac.uk
pronouns: He/him/his

Room 415a, Sir James Black Building, Gilmorehill Campus

Biography

Having completed undergraduate and postgraduate degrees in pharmacology at the University of Cambridge, Professor Will Fuller undertook 8 years of postdoctoral training in the Cardiovascular Division at King’s College London before moving to Dundee in 2006 to establish his own research laboratory. Will transferred his research programme to SCMH in 2017.

Research interests

Research Theme: Cardiac Diseases

The research theme in my laboratory is the organisation and regulation of cardiac membrane proteins and microdomains in health and disease. We employ a variety of subcellular fractionation, imaging, affinity purification, biochemical and cell and organ physiological techniques to investigate molecular, macromolecular, whole cell and whole organ behaviours. Using these approaches, we make fundamental observations into the molecular physiology of membrane proteins, ion transporters and their regulators to better understand both physiological control of cardiac function, and how these relationships can be targeted to ameliorate dysfunction. Our long-term objective is the translation of basic molecular bioscience into therapeutic strategies for cardiovascular diseases.
Current research projects are:

• Regulation of the transmembrane sodium transport by post-translational phosphorylation and palmitoylation of ion transporters, channels, and their regulators.
• Regulation of the ventricular sodium calcium exchanger NCX1 and L-type Ca channel Ca(v)1.2 by palmitoylation.
• Regulation of cardiac voltage-sensitive potassium channels by palmitoylation.
• Regulation of NADPH oxidase superoxide production by palmitoylation.
• Substrate recognition by and regulation of the zDHHC palmitoyl acyl transferase enzymes in health and disease.
• PROTAC-mediated targeted degradation of zDHHC- palmitoyl acyl transferase enzymes, in collaboration with Dr David France, School of Chemistry .
• Phospholamban as a therapeutic target for heart failure.

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000

Number of items: 72.

2024

Main, A., Mary, S. , Sin, Y. Y. , Wright, T. A., Ling, J., Blair, C. M., Smith, G. L. , Fuller, W. and Baillie, G. S. (2024) SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline. International Journal of Biochemistry and Cell Biology, 176, 106668. (doi: 10.1016/j.biocel.2024.106668) (PMID:39321569)

Gök, C. and Fuller, W. (2024) Rise of palmitoylation: a new trick to tune NCX1 activity. Biochimica et Biophysica Acta: Molecular Cell Research, 1871(5), 119719. (doi: 10.1016/j.bbamcr.2024.119719) (PMID:38574822)

Chung, Y. J. et al. (2024) Elevated Na is a dynamic and reversible modulator of mitochondrial metabolism in the heart. Nature Communications, 15, 4277. (doi: 10.1038/s41467-024-48474-z)

Bai, M. et al. (2024) Targeted degradation of zDHHC-PATs decreases substrate S -palmitoylation. PLoS ONE, 19(3), e0299665. (doi: 10.1371/journal.pone.0299665) (PMID:38512906) (PMCID:PMC10956751)

Ashford, F., Kuo, C.-W., Dunning, E., Brown, E., Calagan, S., Jayasinghe, I., Henderson, C., Fuller, W. and Wypijewski, K. (2024) Cysteine post-translational modifications regulate protein interactions of caveolin-3. FASEB Journal, 38(5), e23535. (doi: 10.1096/fj.202201497RR) (PMID:38466300)

Howie, J. et al. (2024) Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6. Cell Reports, 43(2), 113679. (doi: 10.1016/j.celrep.2024.113679) (PMID:38236777)

2023

Fuller, W. and Mejías, R. (2023) Editorial: Protein lipidation in health and disease. Frontiers in Physiology, 14, 1317031. (doi: 10.3389/fphys.2023.1317031) (PMCID:PMC10643125)

Fuller, W. (2023) zDHHC9 and the control of natriuretic peptide secretion by the heart. JACC: Basic to Translational Science, 8(5), pp. 543-545. (doi: 10.1016/j.jacbts.2023.02.013) (PMID:37325402) (PMCID:PMC10264705)

Congreve, S. D., Main, A., Butler, A. S., Gao, X., Brown, E., Du, C., Choisy, S. C., Cheng, H., Hancox, J. C. and Fuller, W. (2023) Palmitoylation regulates the magnitude of HCN4-mediated currents in mammalian cells. Frontiers in Physiology, 14, 1163339. (doi: 10.3389/fphys.2023.1163339) (PMID:37123274) (PMCID:PMC10133559)

Kuo, C.-W. S. et al. (2023) Palmitoylation of the pore-forming subunit of Ca(v)1.2 controls channel voltage sensitivity and calcium transients in cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America, 120(7), e220788712. (doi: 10.1073/pnas.2207887120) (PMID:36745790) (PMCID:PMC9963536)

2022

Cervilla-Martínez, J. F., Rodríguez-Gotor, J. J., Wypijewski, K. J., Fontán-Lozano, Á., Wang, T., Santamaría, E., Fuller, W. and Mejías, R. (2022) Altered cortical palmitoylation induces widespread molecular disturbances in Parkinson's disease. International Journal of Molecular Sciences, 23(22), 14018. (doi: 10.3390/ijms232214018) (PMID:36430497) (PMCID:PMC9696982)

Main, A. et al. (2022) Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies. Frontiers in Physiology, 13, 1023237. (doi: 10.3389/fphys.2022.1023237) (PMID:36277202) (PMCID:PMC9581287)

Gao, X. et al. (2022) Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7. Cell Calcium, 106, 102639. (doi: 10.1016/j.ceca.2022.102639) (PMID:36027648)

Gok, C. , Robertson, A. D. and Fuller, W. (2022) Insulin-induced palmitoylation regulates the Cardiac Na+/Ca2+ Exchanger NCX1. Cell Calcium, 104, 102567. (doi: 10.1016/j.ceca.2022.102567) (PMID:35231700)

Tibbo, A. J. et al. (2022) Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins. Journal of Molecular and Cellular Cardiology, 165, pp. 86-102. (doi: 10.1016/j.yjmcc.2022.01.001) (PMID:34999055) (PMCID:PMC8986152)

Main, A. and Fuller, W. (2022) Protein S‐palmitoylation: advances and challenges in studying a therapeutically important lipid modification. FEBS Journal, 289(4), pp. 861-882. (doi: 10.1111/febs.15781) (PMID:33624421)

Gabriel, J. L., Tinti, M., Fuller, W. and Ashford, M. L.J. (2022) Identifying the beta-site amyloid precursor protein cleaving enzyme 1 interactome through the proximity-dependent biotin identification assay. Neuroscience Letters, 767, 136302. (doi: 10.1016/j.neulet.2021.136302) (PMID:34710551)

2021

Chung, Y. J., Park, K. C., Tokar, S., Eykyn, T. R., Fuller, W. , Pavlovic, D., Swietach, P. and Shattock, M. J. (2021) Off-target effects of SGLT2 blockers: empagliflozin does not inhibit Na+/H+ exchanger-1 or lower [Na+]i in the heart. Cardiovascular Research, 117(14), pp. 2794-2806. (doi: 10.1093/cvr/cvaa323) (PMID:33135077) (PMCID:PMC8683707)

Chung, Y. J., Park, K. C., Tokar, S., Eykyn, T. R., Fuller, W. , Pavlovic, D., Swietach, P. and Shattock, M. J. (2021) SGLT2 inhibitors and the cardiac Na+/H+ exchanger-1: the plot thickens. Cardiovascular Research, 117(14), pp. 2702-2704. (doi: 10.1093/cvr/cvab184) (PMID:34051094) (PMCID:PMC8683703)

Kerr, M. et al. (2021) Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischaemia. FASEB Journal, 35(8), e21765. (doi: 10.1096/fj.202100394R) (PMID:34318967)

Gök, C. , Main, A., Gao, X., Kerekes, Z., Plain, F., Kuo, C.-W., Robertson, A. D., Fraser, N. J. and Fuller, W. (2021) Insights into the molecular basis of the palmitoylation and depalmitoylation of NCX1. Cell Calcium, 97, 102408. (doi: 10.1016/j.ceca.2021.102408) (PMID:33873072)

Robertson-Gray, O. and Fuller, W. (2021) The role of protein S-acylation in cardiac function. Clinical Laboratory International, Feb, pp. 10-13.

Main, A., Robertson-Gray, O. and Fuller, W. (2021) Cyclophilin D palmitoylation and permeability transition: a new twist in the tale of myocardial ischaemia-reperfusion injury. Cardiovascular Research, 117(1), pp. 15-17. (doi: 10.1093/cvr/cvaa149) (PMID:32449761)

Boguslavskyi, A. et al. (2021) Phospholemman phosphorylation regulates vascular tone, blood pressure and hypertension in mice and man. Circulation, 143(11), pp. 1123-1138. (doi: 10.1161/CIRCULATIONAHA.119.040557) (PMID:33334125) (PMCID:PMC7969167)

2020

Gök, C. and Fuller, W. (2020) Topical review: shedding light on molecular and cellular consequences of NCX1 palmitoylation. Cellular Signalling, 76, 109791. (doi: 10.1016/j.cellsig.2020.109791) (PMID:32980495)

Main, A., Fuller, W. and Baillie, G. S. (2020) Post-translational regulation of cardiac myosin binding protein-C: a graphical review. Cellular Signalling, 76, 109788. (doi: 10.1016/j.cellsig.2020.109788) (PMID:32976931)

Aksentijević, D. et al. (2020) Intracellular sodium elevation reprograms cardiac metabolism. Nature Communications, 11, 4337. (doi: 10.1038/s41467-020-18160-x) (PMID:32859897) (PMCID:PMC7455741)

Zou, Z.-G. et al. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. Clinical Science, 134(15), pp. 2019-2035. (doi: 10.1042/CS20200827) (PMID:32706027) (PMCID:PMC8299307)

Plain, F., Howie, J., Kennedy, J., Brown, E., Shattock, M. J., Fraser, N. J. and Fuller, W. (2020) Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase. Communications Biology, 3, 411. (doi: 10.1038/s42003-020-01145-3) (PMID:32737405) (PMCID:PMC7395175)

Gök, C. , Plain, F., Robertson, A., Howie, J., Baillie, G. S. , Fraser, N. J. and Fuller, W. (2020) Dynamic palmitoylation of the sodium-calcium exchanger modulates its structure, affinity for lipid ordered domains, and inhibition by XIP. Cell Reports, 31(10), 107697. (doi: 10.1016/j.celrep.2020.107697) (PMID:32521252) (PMCID:PMC7296346)

Fuller, W. and Gök, C. (2020) Regulation of NCX1 by palmitoylation. Cell Calcium, 86, 102158. (doi: 10.1016/j.ceca.2019.102158) (PMID:31935590)

Fraser, N. J., Howie, J., Wypijewski, K. J. and Fuller, W. (2020) Therapeutic targeting of protein S-acylation for the treatment of disease. Biochemical Society Transactions, 48(1), pp. 281-290. (doi: 10.1042/BST20190707) (PMID:31872231)

2019

Bastug-Özel, Z., Wright, P. T., Kraft, A. E., Pavlovic, D., Howie, J., Froese, A., Fuller, W. , Gorelik, J., Shattock, M. J. and Nikolaev, V. O. (2019) Heart failure leads to altered β2-adrenoceptor/cyclic adenosine monophosphate dynamics in the sarcolemmal phospholemman/Na,K ATPase microdomain. Cardiovascular Research, 115(3), pp. 546-555. (doi: 10.1093/cvr/cvy221) (PMID:30165515)

2018

Norman, R., Fuller, W. and Calaghan, S. (2018) Caveolae and the cardiac myocyte. Current Opinion in Physiology, 1, pp. 59-67. (doi: 10.1016/j.cophys.2017.08.005)

Howie, J., Wypijewski, K. J., Plain, F., Tulloch, L. B., Fraser, N. J. and Fuller, W. (2018) Greasing the wheels or a spanner in the works? Regulation of the cardiac sodium pump by palmitoylation. Critical Reviews in Biochemistry and Molecular Biology, 53(2), pp. 175-191. (doi: 10.1080/10409238.2018.1432560) (PMID:29424237)

2017

Logie, L. et al. (2017) Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3). Scientific Reports, 7, 17682. (doi: 10.1038/s41598-017-17087-6) (PMID:29247183) (PMCID:PMC5732219)

Petrushanko, I. Y. et al. (2017) Cysteine residues 244 and 458–459 within the catalytic subunit of Na,K-ATPase control the enzyme's hydrolytic and signaling function under hypoxic conditions. Redox Biology, 13, pp. 310-319. (doi: 10.1016/j.redox.2017.05.021) (PMID:28601781) (PMCID:PMC5470536)

Plain, F., Congreve, S. D., Yee, R. S. Z., Kennedy, J., Howie, J., Kuo, C.-W., Fraser, N. J. and Fuller, W. (2017) An amphipathic α-helix directs palmitoylation of the large intracellular loop of the sodium/calcium exchanger. Journal of Biological Chemistry, 292(25), pp. 10745-10752. (doi: 10.1074/jbc.M116.773945) (PMID:28432123) (PMCID:PMC5481580)

Hurst, C. H., Turnbull, D., Plain, F., Fuller, W. and Hemsley, P. A. (2017) Maleimide scavenging enhances determination of protein S-palmitoylation state in acyl-exchange methods. BioTechniques, 62(2), pp. 69-75. (doi: 10.2144/000114516) (PMID:28193150) (PMCID:PMC5400063)

Plain, F., Turnbull, D., Fraser, N. J. and Fuller, W. (2017) Understanding the rules governing NCX1 palmitoylation. Channels, 11(5), pp. 377-379. (doi: 10.1080/19336950.2017.1342501) (PMID:28617626)

2016

Hafver, T. L. et al. (2016) Protein phosphatase 1c associated with the cardiac sodium calcium exchanger 1 regulates its activity by dephosphorylating serine 68-phosphorylated phospholemman. Journal of Biological Chemistry, 291(9), pp. 4561-4579. (doi: 10.1074/jbc.M115.677898) (PMID:26668322) (PMCID:PMC4813481)

Fuller, W. , Reilly, L. and Hilgemann, D. W. (2016) S-palmitoylation and the regulation of NCX1. Channels, 10(2), pp. 75-77. (doi: 10.1080/19336950.2015.1099329) (PMID:26418268) (PMCID:PMC4960986)

2015

Reilly, L., Howie, J., Wypijewski, K., Ashford, M. L. J., Hilgemann, D. W. and Fuller, W. (2015) Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling. FASEB Journal, 29(11), pp. 4532-4543. (doi: 10.1096/fj.15-276493) (PMID:26174834) (PMCID:PMC4608915)

Eykyn, T. R., Aksentijević, D., Aughton, K. L., Southworth, R., Fuller, W. and Shattock, M. J. (2015) Multiple quantum filtered 23Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]i. Journal of Molecular and Cellular Cardiology, 86, pp. 95-101. (doi: 10.1016/j.yjmcc.2015.07.009) (PMID:26196304) (PMCID:pmc4564289)

Wypijewski, K. J., Tinti, M., Chen, W., Lamont, D., Ashford, M. L. J., Calaghan, S. C. and Fuller, W. (2015) Identification of caveolar resident proteins in ventricular myocytes using a quantitative proteomic approach: dynamic changes in caveolar composition following adrenoceptor activation. Molecular and Cellular Proteomics, 14(3), pp. 596-608. (doi: 10.1074/mcp.M114.038570) (PMID:25561500) (PMCID:PMC4349980)

2014

Howie, J. et al. (2014) Substrate recognition by the cell surface palmitoyl transferase DHHC5. Proceedings of the National Academy of Sciences of the United States of America, 111(49), pp. 17534-17539. (doi: 10.1073/pnas.1413627111) (PMID:25422474) (PMCID:PMC4267385)

Boguslavskyi, A., Pavlovic, D., Aughton, K., Clark, J. E., Howie, J., Fuller, W. and Shattock, M. J. (2014) Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman. Cardiovascular Research, 104(1), pp. 72-82. (doi: 10.1093/cvr/cvu182) (PMID:25103111) (PMCID:PMC4174889)

2013

Pavlovic, D., Fuller, W. and Shattock, M. J. (2013) Novel regulation of cardiac Na pump via phospholemman. Journal of Molecular and Cellular Cardiology, 61, pp. 83-93. (doi: 10.1016/j.yjmcc.2013.05.002) (PMID:23672825)

Pavlovic, D., Hall, A. R., Kennington, E. J., Aughton, K., Boguslavskyi, A., Fuller, W. , Despa, S., Bers, D. M. and Shattock, M. J. (2013) Nitric oxide regulates cardiac intracellular Na+ and Ca2+ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism. Journal of Molecular and Cellular Cardiology, 61, pp. 164-171. (doi: 10.1016/j.yjmcc.2013.04.013) (PMID:23612119) (PMCID:PMC3981027)

Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C. and Fuller, W. (2013) A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump. Journal of Biological Chemistry, 288(19), pp. 13808-13820. (doi: 10.1074/jbc.M113.460956) (PMID:23532852) (PMCID:PMC3650417)

Fuller, W. , Tulloch, L.B., Shattock, M.J., Calaghan, S.C., Howie, J. and Wypijewski, K.J. (2013) Regulation of the cardiac sodium pump. Cellular and Molecular Life Sciences, 70(8), pp. 1357-1380. (doi: 10.1007/s00018-012-1134-y) (PMID:22955490) (PMCID:PMC3607738)

Howie, J., Tulloch, L. B., Shattock, M. J. and Fuller, W. (2013) Regulation of the cardiac Na+ pump by palmitoylation of its catalytic and regulatory subunits. Biochemical Society Transactions, 41(1), pp. 95-100. (doi: 10.1042/BST20120269) (PMID:23356265)

2011

El-Armouche, A., Wittköpper, K., Fuller, W. , Howie, J., Shattock, M. J. and Pavlovic, D. (2011) Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase. FASEB Journal, 25(12), pp. 4467-4475. (doi: 10.1096/fj.11-184903) (PMID:21849407)

Tulloch, L. B., Howie, J., Wypijewski, K. J., Wilson, C. R., Bernard, W. G., Shattock, M. J. and Fuller, W. (2011) The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation. Journal of Biological Chemistry, 286(41), pp. 36020-36031. (doi: 10.1074/jbc.M111.282145) (PMID:21868384) (PMCID:PMC3195638)

2010

Madhani, M., Hall, A. R., Cuello, F., Charles, R. L., Burgoyne, J. R., Fuller, W. , Hobbs, A. J., Shattock, M. J. and Eaton, P. (2010) Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury. American Journal of Physiology: Heart and Circulatory Physiology, 299(3), H827-H836. (doi: 10.1152/ajpheart.00129.2010) (PMID:20543084) (PMCID:PMC2944484)

2009

Fuller, W. , Howie, J., McLatchie, L. M., Weber, R. J., Hastie, C. J., Burness, K., Pavlovic, D. and Shattock, M. J. (2009) FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine 69 is a novel substrate for protein kinase C. American Journal of Physiology: Cell Physiology, 296(6), C1346-C1355. (doi: 10.1152/ajpcell.00523.2008) (PMID:19339511) (PMCID:PMC2692419)

2008

Armitage, J. A., Gupta, S., Wood, C., Jensen, R. I., Samuelsson, A.-M., Fuller, W. , Shattock, M. J., Poston, L. and Taylor, P. D. (2008) Maternal dietary supplementation with saturated, but not monounsaturated or polyunsaturated fatty acids, leads to tissue-specific inhibition of offspring Na+,K+-ATPase. Journal of Physiology, 586(20), pp. 5013-5022. (doi: 10.1113/jphysiol.2008.157818) (PMID:18718984)

Pavlović, D., Fuller, W. and Shattock, M. J. (2008) The intracellular region of FXYD1 is sufficient to regulate cardiac Na/K ATPase. FASEB Journal, 21(7), pp. 1539-1546. (doi: 10.1096/fj.06-7269com) (PMID:17283221)

Bell, J. R. et al. (2008) Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity. American Journal of Physiology: Heart and Circulatory Physiology, 294(2), H613-H621. (doi: 10.1152/ajpheart.01332.2007) (PMID:18065526)

2007

Berry, R. G., Despa, S., Fuller, W. , Bers, D. M. and Shattock, M. J. (2007) Differential distribution and regulation of mouse cardiac Na+/K+-ATPase α1 and α2 subunits in T-tubule and surface sarcolemmal membranes. Cardiovascular Research, 73(1), pp. 92-100. (doi: 10.1016/j.cardiores.2006.11.006) (PMID:17157829)

2006

Fuller, W. and Shattock, M.J. (2006) Phospholemman and the cardiac sodium pump: protein kinase C, take a bow. Circulation Research, 99(12), pp. 1290-1292. (doi: 10.1161/01.RES.0000253090.54488.81) (PMID:17158344)

Brennan, J. P., Bardswell, S. C., Burgoyne, J. R., Fuller, W. , Schröder, E., Wait, R., Begum, S., Kentish, J. C. and Eaton, P. (2006) Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation. Journal of Biological Chemistry, 281(31), pp. 21827-21836. (doi: 10.1074/jbc.M603952200) (PMID:16754666)

2005

Brennan, J. P., Miller, J. I.A., Fuller, W. , Wait, R., Begum, S., Dunn, M. J. and Eaton, P. (2005) The utility of N,N-biotinyl glutathione disulfide in the study of protein S-glutathiolation. Molecular and Cellular Proteomics, 5(2), pp. 215-225. (doi: 10.1074/mcp.M500212-MCP200) (PMID:16223748)

Silverman, B. d.Z., Fuller, W. , Eaton, P., Deng, J., Moorman, J. R., Cheung, J. Y., James, A. F. and Shattock, M. J. (2005) Serine 68 phosphorylation of phospholemman: acute isoform-specific activation of cardiac Na/K ATPase. Cardiovascular Research, 65(1), pp. 93-103. (doi: 10.1016/j.cardiores.2004.09.005) (PMID:15621037)

2004

Fuller, W. , Eeaton, P., Bell, J. R. and Shattock, M. J. (2004) Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase. FASEB Journal, 18(1), pp. 197-199. (doi: 10.1096/fj.03-0213fje) (PMID:14597563)

2003

Cuthbert, A. W. and Fuller, W. (2003) Investigation of folding and degradation of in vitro synthesized mutant proteins in microsomes. Methods in Molecular Biology, 232, pp. 265-284. (doi: 10.1385/1-59259-394-1:265) (PMID:12840556)

2002

Eaton, P., Fuller, W. and Shattock, M. J. (2002) S-thiolation of HSP27 regulates its multimeric aggregate size independently of phosphorylation. Journal of Biological Chemistry, 277(24), pp. 21189-21196. (doi: 10.1074/jbc.M200591200) (PMID:11925435)

Fuller, W. , Parmar, V., Eaton, P., Bell, J. R. and Shattock, M. J. (2002) Cardiac ischemia causes inhibition of the Na/K ATPase by a labile cytosolic compound whose production is linked to oxidant stress. Cardiovascular Research, 57(4), pp. 1044-1051. (doi: 10.1016/S0008-6363(02)00810-6) (PMID:12650882)

Medina, R. A., Southworth, R., Fuller, W. and Garlick, P. B. (2002) Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by the phosphatidylinositol-3-kinase pathway in the rat heart. Basic Research in Cardiology, 97(2), pp. 168-176. (doi: 10.1007/s003950200008) (PMID:12002265)

2001

Fuller, W. , Eaton, P., Medina, R. A., Bell, J. and Shattock, M. J. (2001) Differential centrifugation separates cardiac sarcolemmal and endosomal membranes from Langendorff-perfused rat hearts. Analytical Biochemistry, 293(2), pp. 216-223. (doi: 10.1006/abio.2001.5127) (PMID:11399035)

Eaton, P., Fuller, W. , Bell, J. R. and Shattock, M. J. (2001) Alpha B crystallin translocation and phosphorylation: signal transduction pathways and preconditioning in the isolated rat heart. Journal of Molecular and Cellular Cardiology, 33(9), pp. 1659-1671. (doi: 10.1006/jmcc.2001.1418) (PMID:11549345)

2000

Fuller, W. and Cuthbert, A. W. (2000) Post-translational disruption of the delta F508 cystic fibrosis transmembrane conductance regulator (CFTR)-molecular chaperone complex with geldanamycin stabilizes delta F508 CFTR in the rabbit reticulocyte lysate. Journal of Biological Chemistry, 275(48), pp. 37462-37468. (doi: 10.1074/jbc.M006278200) (PMID:10982807)

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Number of items: 72.

Articles

Chung, Y. J. et al. (2024) Elevated Na is a dynamic and reversible modulator of mitochondrial metabolism in the heart. Nature Communications, 15, 4277. (doi: 10.1038/s41467-024-48474-z)

Bai, M. et al. (2024) Targeted degradation of zDHHC-PATs decreases substrate S -palmitoylation. PLoS ONE, 19(3), e0299665. (doi: 10.1371/journal.pone.0299665) (PMID:38512906) (PMCID:PMC10956751)

Howie, J. et al. (2024) Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6. Cell Reports, 43(2), 113679. (doi: 10.1016/j.celrep.2024.113679) (PMID:38236777)

Fuller, W. and Mejías, R. (2023) Editorial: Protein lipidation in health and disease. Frontiers in Physiology, 14, 1317031. (doi: 10.3389/fphys.2023.1317031) (PMCID:PMC10643125)

Gao, X. et al. (2022) Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7. Cell Calcium, 106, 102639. (doi: 10.1016/j.ceca.2022.102639) (PMID:36027648)

Robertson-Gray, O. and Fuller, W. (2021) The role of protein S-acylation in cardiac function. Clinical Laboratory International, Feb, pp. 10-13.

Aksentijević, D. et al. (2020) Intracellular sodium elevation reprograms cardiac metabolism. Nature Communications, 11, 4337. (doi: 10.1038/s41467-020-18160-x) (PMID:32859897) (PMCID:PMC7455741)

Fuller, W. and Gök, C. (2020) Regulation of NCX1 by palmitoylation. Cell Calcium, 86, 102158. (doi: 10.1016/j.ceca.2019.102158) (PMID:31935590)

Norman, R., Fuller, W. and Calaghan, S. (2018) Caveolae and the cardiac myocyte. Current Opinion in Physiology, 1, pp. 59-67. (doi: 10.1016/j.cophys.2017.08.005)

Fuller, W. , Reilly, L. and Hilgemann, D. W. (2016) S-palmitoylation and the regulation of NCX1. Channels, 10(2), pp. 75-77. (doi: 10.1080/19336950.2015.1099329) (PMID:26418268) (PMCID:PMC4960986)

This list was generated on Wed Nov 20 16:46:55 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

Palm-TACs - palmitoylation targeting chimaeras. Genetic and pharmacological reagents to specifically target protein S-Palmitoylation
Biotechnology and Biological Sciences Research Council
2024 - 2027
Palmitoylation and regulation of a potassium channel of central importance in cardiac electrophysiology
British Heart Foundation
2023 - 2025
Therapeutic Manipulation of NCX1 activity
British Heart Foundation
2022 - 2025
Inhibitory G protein S-acylation as a therapeutic target in heart failure
British Heart Foundation
2019 - 2022
Palmitoylation of the L-Type Ca Channel Pore-Forming Subunit
British Heart Foundation
2018 - 2021
Small molecules activating Nrf2 as a therapeutic approach to prevent cardiac ischemiareperfusion
British Heart Foundation
2018 - 2019
The Na/K ATPase in cardiovascular health and disease
British Heart Foundation
2017 - 2021

Supervision

Adu, Samuel
Vascular redox signalling and protein oxidation in hypertens
Dickson-Murray, Eleanor
Palmitoylation and the regulation of the cardiac transient outward current

Research datasets

Jump to: 2024 | 2022

Number of items: 3.

2024

Ashford, F., Kuo, C.-W., Dunning, E., Brown, E., Calaghan, S., Jayasinghe, I., Henderson, C., Fuller, W. and Wypijewski, K. (2024) Cysteine post-translational modifications regulate protein interactions of caveolin-3. [Data Collection]

2022

Kuo, C.-W., Dobi, S. , Gok, C. , Costa, A., Main, A., MacQuaide, N. and Fuller, W. (2022) Palmitoylation of the pore-forming subunit of Ca(v)1.2 controls channel voltage sensitivity and calcium transients in cardiac myocytes. [Data Collection]

GAO, X., Samji, S. and Fuller, W. (2022) Proteomic analysis of TrpM7 interacting proteins in HEK cells. [Data Collection]

This list was generated on Thu Nov 21 06:45:47 2024 GMT.

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Professor Will Fuller

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