Dr Sheon Samji

  • Research Fellow (School of Cardiovascular & Metabolic Health)

Biography

Sheon Mary Samji is a Research Fellow at the School of Cardiovascular and Metabolic Health (SCMH) at the University of Glasgow, specializing in molecular biology with a focus on proteomics. With over 12 years of academic and research experience, her expertise spans protein mass spectrometry, cell and molecular biology, and biochemistry.

Her academic journey began with a BSc and MSc in Biotechnology from the University of Pune, India, followed by a PhD in Biochemical Sciences from CSIR-National Chemical Laboratory (India), where she investigated proteomic patterns in pre-eclampsia. Sheon joined University of Glasgow as Newton International Fellow in 2018 funded by the Academy of Medical Sciences and the Royal Society. Before her tenure in Glasgow, she worked as a scientist at Enzene Bioscience Ltd (India), managing teams to characterize therapeutic biosimilars and novel medicinal compounds.

Her research interests revolve around understanding the molecular mechanisms underlying cardiovascular and renal diseases. Her work focuses on uromodulin, a protein linked to salt-sensitive hypertension and kidney function, investigating its role in the regulation of cardiovascular health and its response to environmental factors like salt, pregnancy, diabetes, heart failure and hypertension. Beyond research, Dr. Samji is actively involved in mentoring PhD students and teaching courses on proteomics, and she plays a key role in promoting equality and mental health awareness within SCMH.

Research interests

Research Theme: Vascular Diseases and Comorbidities

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2014 | 2013 | 2012
Number of items: 29.

2024

Main, A., Mary, S. , Sin, Y. Y. , Wright, T. A., Ling, J., Blair, C. M., Smith, G. L. , Fuller, W. and Baillie, G. S. (2024) SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline. International Journal of Biochemistry and Cell Biology, 176, 106668. (doi: 10.1016/j.biocel.2024.106668) (PMID:39321569)

Zhou, M., Mary, S. , Delles, C. , Padmanabhan, S. , Graham, D. , McBride, M. W. and Dominiczak, A. (2024) Insights into uromodulin and blood pressure. Current Hypertension Reports, (doi: 10.1007/s11906-024-01317-0) (PMID:39259220) (Early Online Publication)

Mary, S. et al. (2024) Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension. Journal of Nephrology, (doi: 10.1007/s40620-023-01830-6) (PMID:38236469) (Early Online Publication)

2023

de Beer, D., MC. Mels, C., Schutte, A., Delles, C. , Mary, S. , Mullen, W. , Mischak, H. and Kruger, R. (2023) Urinary peptidomics and pulse wave velocity: The African-PREDICT study. Journal of Proteome Research, 22(10), pp. 3282-3289. (doi: 10.1021/acs.jproteome.3c00347) (PMID:37688558) (PMCID:PMC10563154)

Montezano, A. C. et al. (2023) SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication. Scientific Reports, 13, 14086. (doi: 10.1038/s41598-023-41115-3) (PMID:37640791) (PMCID:PMC10462711)

De Beer, D., Mels, C. M.C., Schutte, A. E., Delles, C. , Mary, S. , Mullen, W. , Latosinska, A., Mischak, H. and Kruger, R. (2023) Identifying a urinary peptidomics profile for hypertension in young adults: the African-PREDICT study. Proteomics, 23(11), 2200444. (doi: 10.1002/pmic.202200444) (PMID:36943111)

Chen, J. Y., Chew, K. S., Mary, S. , Boder, P., Bagordo, D., Rossi, G. P., Touyz, R. M. , Delles, C. and Rossitto, G. (2023) Skin-specific mechanisms of body fluid regulation in hypertension. Clinical Science, 137(3), pp. 239-250. (doi: 10.1042/CS20220609) (PMID:36648486)

de Beer, D., Mels, C. M. C., Schutte, A. E., Delles, C. , Mary, S. , Mullen, W. , Mischak, H. and Kruger, R. (2023) A urinary peptidomics approach for early stages of cardiovascular disease risk: the African-PREDICT study. Hypertension Research, 46(2), pp. 485-494. (doi: 10.1038/s41440-022-01097-7) (PMID:36396816)

2022

Mary, S. , Boder, P., Padmanabhan, S. , McBride, M. W. , Graham, D. , Delles, C. and Dominiczak, A. F. (2022) The role of uromodulin in salt-sensitive hypertension. Hypertension, 79, pp. 2419-2429. (doi: 10.1161/HYPERTENSIONAHA.122.19888) (PMID:36378920) (PMCID:PMC9553220)

Mary, S. , Rossitto, G. and Delles, C. (2022) Pathophysiology of hypertension. In: Nadar, S. and Lip, G. (eds.) Hypertension. Series: Oxford cardiology library. Oxford University Press: Oxford, pp. 11-20. ISBN 9780198870678 (doi: 10.1093/med/9780198870678.003.0002)

Gao, X. et al. (2022) Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7. Cell Calcium, 106, 102639. (doi: 10.1016/j.ceca.2022.102639) (PMID:36027648)

2021

Mary, S. , Boder, P., Rossitto, G., Graham, L., Scott, K. , Flynn, A., Kipgen, D., Graham, D. and Delles, C. (2021) Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats. Clinical Science, 135(24), pp. 2749-2761. (doi: 10.1042/CS20211017) (PMID:34870708) (PMCID:PMC8689196)

Boder, P., Mary, S. , Mark, P. B. , Leiper, J. , Dominiczak, A. F. , Padmanabhan, S. , Rampold, L. and Delles, C. (2021) Mechanistic interactions of uromodulin with the thick ascending limb: perspectives in physiology and hypertension. Journal of Hypertension, 39(8), pp. 1490-1504. (doi: 10.1097/HJH.0000000000002861) (PMID:34187999) (PMCID:PMC7611110)

Mary, S. , Small, H., Herse, F., Carrick, E., Flynn, A., Mullen, W. , Dechend, R. and Delles, C. (2021) Pre-existing hypertension and pregnancy induced hypertension reveal molecular differences in placental proteome in rodents. Physiological Genomics, 53(6), pp. 259-268. (doi: 10.1152/physiolgenomics.00160.2020) (PMID:33969702)

Rossitto, G. et al. (2021) High sodium intake, glomerular hyperfiltration and protein catabolism in patients with essential hypertension. Cardiovascular Research, 117(5), pp. 1372-1381. (doi: 10.1093/cvr/cvaa205) (PMID:33053160) (PMCID:PMC8064429)

2020

Rossitto, G. et al. (2020) Reduced lymphatic reserve in heart failure with preserved ejection fraction. Journal of the American College of Cardiology, 76(24), pp. 2817-2829. (doi: 10.1016/j.jacc.2020.10.022) (PMID:33303070) (PMCID:PMC7724570)

Rossitto, G. et al. (2020) Tissue sodium excess is not hypertonic and reflects extracellular volume expansion. Nature Communications, 11, 4222. (doi: 10.1038/s41467-020-17820-2) (PMID:32839436) (PMCID:PMC7445299)

Currie, G. , Mary, S. and Delles, C. (2020) Is there a role for proteomics in diabetic renal disease? NDT Plus, 35(7), pp. 1133-1135. (doi: 10.1093/ndt/gfz017) (PMID:32777079) (PMCID:PMC7417003)

Mary, S. , Currie, G. , Schutte, A. E. and Delles, C. (2020) Cardiovascular proteomics. In: Faintuch, J. and Faintuch, S. (eds.) Precision Medicine for Investigators, Practitioners and Providers. Academic Press: London ; San Diego, CA, pp. 263-270. ISBN 9780128191781 (doi: 10.1016/b978-0-12-819178-1.00025-3)

2019

Small, H. Y., McNeilly, S., Mary, S. , Sheikh, A. M. and Delles, C. (2019) Resistin mediates sex-dependent effects of perivascular adipose tissue on vascular function in the SHRSP. Scientific Reports, 9, 6897. (doi: 10.1038/s41598-019-43326-z) (PMID:31053755) (PMCID:PMC6499830)

2018

Currie, G. E. et al. (2018) Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria. Cardiovascular Diabetology, 17, 50. (doi: 10.1186/s12933-018-0697-9) (PMID:29625564) (PMCID:PMC5889591)

2017

Mary, S. , Kulkarni, M. J., Mehendale, S. S., Joshi, S. R. and Giri, A. P. (2017) Differential accumulation of vimentin fragments in preeclamptic placenta. Cytoskeleton, 74(11), pp. 420-425. (doi: 10.1002/cm.21390) (PMID:28752964)

Bhat, S., Mary, S. , Giri, A. P. and Kulkarni, M. J. (2017) Advanced glycation end products (AGEs) in diabetic complications. In: Kartha, C.C., Ramachandran, S. and Pillai, R. M. (eds.) Mechanisms of Vascular Defects in Diabetes Mellitus. Series: Advances in biochemistry in health and disease (17). Springer: Cham, pp. 423-449. ISBN 9783319603230 (doi: 10.1007/978-3-319-60324-7_19)

Mary, S. , Small, H. Y., Siwy, J., Mullen, W. , Giri, A. and Delles, C. (2017) Polymerization-incompetent uromodulin in the pregnant stroke-prone spontaneously hypertensive rat. Hypertension, 69(5), pp. 910-918. (doi: 10.1161/HYPERTENSIONAHA.116.08826) (PMID:28348009) (PMCID:PMC5389592)

Mary, S. , Kulkarni, M. J., Mehendale, S. S., Joshi, S. R. and Giri, A. P. (2017) Tubulointerstitial nephritis antigen-like 1 protein is downregulated in the placenta of pre-eclamptic women. Clinical Proteomics, 14, 8. (doi: 10.1186/s12014-017-9144-2) (PMID:28344540) (PMCID:PMC5361709)

Mary, S. , Kulkarni, M. J., Malakar, D., Joshi, S. R., Mehendale, S. S. and Giri, A. P. (2017) Placental proteomics provides insights into pathophysiology of pre-eclampsia and predicts possible markers in plasma. Journal of Proteome Research, 16(2), pp. 1050-1060. (doi: 10.1021/acs.jproteome.6b00955) (PMID:28030762)

2014

Bhat, S., Mary, S. , Banarjee, R., Giri, A. P. and Kulkarni, M. J. (2014) Immune response to chemically modified proteome. Proteomics Clinical Applications, 8(1-2), pp. 19-34. (doi: 10.1002/prca.201300068) (PMID:24375944)

2013

Kulkarni, M. J., Korwar, A. M., Mary, S. , Bhonsle, H. S. and Giri, A. P. (2013) Glycated proteome: from reaction to intervention. Proteomics Clinical Applications, 7(1-2), pp. 155-170. (doi: 10.1002/prca.201200101) (PMID:23184864)

2012

Mary, S. , Patil, G. V., Kulkarni, A. V., Kulkarni, M. J., Joshi, S. R., Mehendale, S. S. and Giri, A. P. (2012) Dynamic proteome in enigmatic preeclampsia: an account of molecular mechanisms and biomarker discovery. Proteomics Clinical Applications, 6(1-2), pp. 79-90. (doi: 10.1002/prca.201100089) (PMID:22447695)

This list was generated on Thu Nov 21 03:25:16 2024 GMT.
Jump to: Articles | Book Sections
Number of items: 29.

Articles

Main, A., Mary, S. , Sin, Y. Y. , Wright, T. A., Ling, J., Blair, C. M., Smith, G. L. , Fuller, W. and Baillie, G. S. (2024) SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline. International Journal of Biochemistry and Cell Biology, 176, 106668. (doi: 10.1016/j.biocel.2024.106668) (PMID:39321569)

Zhou, M., Mary, S. , Delles, C. , Padmanabhan, S. , Graham, D. , McBride, M. W. and Dominiczak, A. (2024) Insights into uromodulin and blood pressure. Current Hypertension Reports, (doi: 10.1007/s11906-024-01317-0) (PMID:39259220) (Early Online Publication)

Mary, S. et al. (2024) Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension. Journal of Nephrology, (doi: 10.1007/s40620-023-01830-6) (PMID:38236469) (Early Online Publication)

de Beer, D., MC. Mels, C., Schutte, A., Delles, C. , Mary, S. , Mullen, W. , Mischak, H. and Kruger, R. (2023) Urinary peptidomics and pulse wave velocity: The African-PREDICT study. Journal of Proteome Research, 22(10), pp. 3282-3289. (doi: 10.1021/acs.jproteome.3c00347) (PMID:37688558) (PMCID:PMC10563154)

Montezano, A. C. et al. (2023) SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication. Scientific Reports, 13, 14086. (doi: 10.1038/s41598-023-41115-3) (PMID:37640791) (PMCID:PMC10462711)

De Beer, D., Mels, C. M.C., Schutte, A. E., Delles, C. , Mary, S. , Mullen, W. , Latosinska, A., Mischak, H. and Kruger, R. (2023) Identifying a urinary peptidomics profile for hypertension in young adults: the African-PREDICT study. Proteomics, 23(11), 2200444. (doi: 10.1002/pmic.202200444) (PMID:36943111)

Chen, J. Y., Chew, K. S., Mary, S. , Boder, P., Bagordo, D., Rossi, G. P., Touyz, R. M. , Delles, C. and Rossitto, G. (2023) Skin-specific mechanisms of body fluid regulation in hypertension. Clinical Science, 137(3), pp. 239-250. (doi: 10.1042/CS20220609) (PMID:36648486)

de Beer, D., Mels, C. M. C., Schutte, A. E., Delles, C. , Mary, S. , Mullen, W. , Mischak, H. and Kruger, R. (2023) A urinary peptidomics approach for early stages of cardiovascular disease risk: the African-PREDICT study. Hypertension Research, 46(2), pp. 485-494. (doi: 10.1038/s41440-022-01097-7) (PMID:36396816)

Mary, S. , Boder, P., Padmanabhan, S. , McBride, M. W. , Graham, D. , Delles, C. and Dominiczak, A. F. (2022) The role of uromodulin in salt-sensitive hypertension. Hypertension, 79, pp. 2419-2429. (doi: 10.1161/HYPERTENSIONAHA.122.19888) (PMID:36378920) (PMCID:PMC9553220)

Gao, X. et al. (2022) Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7. Cell Calcium, 106, 102639. (doi: 10.1016/j.ceca.2022.102639) (PMID:36027648)

Mary, S. , Boder, P., Rossitto, G., Graham, L., Scott, K. , Flynn, A., Kipgen, D., Graham, D. and Delles, C. (2021) Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats. Clinical Science, 135(24), pp. 2749-2761. (doi: 10.1042/CS20211017) (PMID:34870708) (PMCID:PMC8689196)

Boder, P., Mary, S. , Mark, P. B. , Leiper, J. , Dominiczak, A. F. , Padmanabhan, S. , Rampold, L. and Delles, C. (2021) Mechanistic interactions of uromodulin with the thick ascending limb: perspectives in physiology and hypertension. Journal of Hypertension, 39(8), pp. 1490-1504. (doi: 10.1097/HJH.0000000000002861) (PMID:34187999) (PMCID:PMC7611110)

Mary, S. , Small, H., Herse, F., Carrick, E., Flynn, A., Mullen, W. , Dechend, R. and Delles, C. (2021) Pre-existing hypertension and pregnancy induced hypertension reveal molecular differences in placental proteome in rodents. Physiological Genomics, 53(6), pp. 259-268. (doi: 10.1152/physiolgenomics.00160.2020) (PMID:33969702)

Rossitto, G. et al. (2021) High sodium intake, glomerular hyperfiltration and protein catabolism in patients with essential hypertension. Cardiovascular Research, 117(5), pp. 1372-1381. (doi: 10.1093/cvr/cvaa205) (PMID:33053160) (PMCID:PMC8064429)

Rossitto, G. et al. (2020) Reduced lymphatic reserve in heart failure with preserved ejection fraction. Journal of the American College of Cardiology, 76(24), pp. 2817-2829. (doi: 10.1016/j.jacc.2020.10.022) (PMID:33303070) (PMCID:PMC7724570)

Rossitto, G. et al. (2020) Tissue sodium excess is not hypertonic and reflects extracellular volume expansion. Nature Communications, 11, 4222. (doi: 10.1038/s41467-020-17820-2) (PMID:32839436) (PMCID:PMC7445299)

Currie, G. , Mary, S. and Delles, C. (2020) Is there a role for proteomics in diabetic renal disease? NDT Plus, 35(7), pp. 1133-1135. (doi: 10.1093/ndt/gfz017) (PMID:32777079) (PMCID:PMC7417003)

Small, H. Y., McNeilly, S., Mary, S. , Sheikh, A. M. and Delles, C. (2019) Resistin mediates sex-dependent effects of perivascular adipose tissue on vascular function in the SHRSP. Scientific Reports, 9, 6897. (doi: 10.1038/s41598-019-43326-z) (PMID:31053755) (PMCID:PMC6499830)

Currie, G. E. et al. (2018) Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria. Cardiovascular Diabetology, 17, 50. (doi: 10.1186/s12933-018-0697-9) (PMID:29625564) (PMCID:PMC5889591)

Mary, S. , Kulkarni, M. J., Mehendale, S. S., Joshi, S. R. and Giri, A. P. (2017) Differential accumulation of vimentin fragments in preeclamptic placenta. Cytoskeleton, 74(11), pp. 420-425. (doi: 10.1002/cm.21390) (PMID:28752964)

Mary, S. , Small, H. Y., Siwy, J., Mullen, W. , Giri, A. and Delles, C. (2017) Polymerization-incompetent uromodulin in the pregnant stroke-prone spontaneously hypertensive rat. Hypertension, 69(5), pp. 910-918. (doi: 10.1161/HYPERTENSIONAHA.116.08826) (PMID:28348009) (PMCID:PMC5389592)

Mary, S. , Kulkarni, M. J., Mehendale, S. S., Joshi, S. R. and Giri, A. P. (2017) Tubulointerstitial nephritis antigen-like 1 protein is downregulated in the placenta of pre-eclamptic women. Clinical Proteomics, 14, 8. (doi: 10.1186/s12014-017-9144-2) (PMID:28344540) (PMCID:PMC5361709)

Mary, S. , Kulkarni, M. J., Malakar, D., Joshi, S. R., Mehendale, S. S. and Giri, A. P. (2017) Placental proteomics provides insights into pathophysiology of pre-eclampsia and predicts possible markers in plasma. Journal of Proteome Research, 16(2), pp. 1050-1060. (doi: 10.1021/acs.jproteome.6b00955) (PMID:28030762)

Bhat, S., Mary, S. , Banarjee, R., Giri, A. P. and Kulkarni, M. J. (2014) Immune response to chemically modified proteome. Proteomics Clinical Applications, 8(1-2), pp. 19-34. (doi: 10.1002/prca.201300068) (PMID:24375944)

Kulkarni, M. J., Korwar, A. M., Mary, S. , Bhonsle, H. S. and Giri, A. P. (2013) Glycated proteome: from reaction to intervention. Proteomics Clinical Applications, 7(1-2), pp. 155-170. (doi: 10.1002/prca.201200101) (PMID:23184864)

Mary, S. , Patil, G. V., Kulkarni, A. V., Kulkarni, M. J., Joshi, S. R., Mehendale, S. S. and Giri, A. P. (2012) Dynamic proteome in enigmatic preeclampsia: an account of molecular mechanisms and biomarker discovery. Proteomics Clinical Applications, 6(1-2), pp. 79-90. (doi: 10.1002/prca.201100089) (PMID:22447695)

Book Sections

Mary, S. , Rossitto, G. and Delles, C. (2022) Pathophysiology of hypertension. In: Nadar, S. and Lip, G. (eds.) Hypertension. Series: Oxford cardiology library. Oxford University Press: Oxford, pp. 11-20. ISBN 9780198870678 (doi: 10.1093/med/9780198870678.003.0002)

Mary, S. , Currie, G. , Schutte, A. E. and Delles, C. (2020) Cardiovascular proteomics. In: Faintuch, J. and Faintuch, S. (eds.) Precision Medicine for Investigators, Practitioners and Providers. Academic Press: London ; San Diego, CA, pp. 263-270. ISBN 9780128191781 (doi: 10.1016/b978-0-12-819178-1.00025-3)

Bhat, S., Mary, S. , Giri, A. P. and Kulkarni, M. J. (2017) Advanced glycation end products (AGEs) in diabetic complications. In: Kartha, C.C., Ramachandran, S. and Pillai, R. M. (eds.) Mechanisms of Vascular Defects in Diabetes Mellitus. Series: Advances in biochemistry in health and disease (17). Springer: Cham, pp. 423-449. ISBN 9783319603230 (doi: 10.1007/978-3-319-60324-7_19)

This list was generated on Thu Nov 21 03:25:16 2024 GMT.

Teaching

Sheon is on a research-only track, the majority of my teaching efforts involve mentoring PhD students, PGT, UGT and other junior colleagues. Apart from research focused teaching, she is involved in formal teaching and grading on L5- proteomics: clinical biomarker for Masters students (Biotechnology applications) for School of Molecular Biosciences.

Professional activities & recognition

Research fellowships

  • 2018 - 2020: Newton International Fellowship, The Royal Society
  • 2011 - 2016: CSIR research fellowship, Govt of India
  • 2015 - 2016: Commonwealth Split-Site Scholarship

Research datasets

Jump to: 2022
Number of items: 1.

2022

GAO, X., Samji, S. and Fuller, W. (2022) Proteomic analysis of TrpM7 interacting proteins in HEK cells. [Data Collection]

This list was generated on Thu Nov 21 03:25:18 2024 GMT.

Dr Sheon Samji