Professor Rachel Myles

  • Professor (Cardiovascular & Metabolic Health)

email: Rachel.Myles@glasgow.ac.uk

RC342 Level C3, Institute of C&MS, Bhf Gcrc, Glasgow G12 8TA

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-4670-361X

Biography

Dr Rachel Myles trained in medicine at the University of Oxford, gaining a First Class degree in Physiological Sciences, and thereafter at Guy’s and St. Thomas’ Hospital in London, graduating in 2001. She undertook general professional training in medicine at the Royal Infirmary of Edinburgh before moving to Glasgow in 2004 to pursue a career in academic and clinical cardiac electrophysiology. She completed a PhD in cardiac electrophysiology under the supervision of Professors Stuart Cobbe and Godfrey Smith in 2008 and was appointed as a Clinical Lecturer in Cardiology. She now divides her time between clinical training in cardiology and electrophysiology, and research into the mechanisms of ventricular arrhythmias in heart failure. She recently undertook a post-doctoral research fellowship at the University of California, Davis. 

Research interests

Research Theme: Cardiac Diseases 

My current research approach combines both clinical and laboratory-based research, which utilizes optical imaging techniques to record voltage signals from intact myocardium in order to investigate the mechanisms of ventricular arrhythmias and sudden death in heart failure.

Research: Ventricular Arrhythmia Mechanisms

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008
Number of items: 36.

2024

Shead, K. D., Huethorst, E. , Burton, F., Lang, N. , Myles, R. C. and Smith, G. L. (2024) Human induced pluripotent stem cell derived cardiomyocytes for pre-clinical cardiotoxicity screening. JACC: CardioOncology, (Accepted for Publication)

Freeman, M., Huethorst, E. , Boland, E., Dunne, M., Burton, F., Denning, C., Myles, R. and Smith, G. (2024) A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit. American Journal of Physiology: Heart and Circulatory Physiology, 326(3), H735--H751. (doi: 10.1152/ajpheart.00657.2023) (PMID:38180449)

2023

Simitev, R. D. , Al dawoud, A., Aziz, M. H.N., Myles, R. and Smith, G. L. (2023) Phenomenological analysis of simple ion channel block in large populations of uncoupled cardiomyocytes. Mathematical Medicine and Biology, 40(2), pp. 175-198. (doi: 10.1093/imammb/dqad001) (PMID:36689769)

Mooney, L., Jackson, C. E., Adamson, C., McConnachie, A. , Welsh, P. , Myles, R. C. , McMurray, J. J.V. , Jhund, P. S. , Petrie, M. C. and Lang, N. N. (2023) Adverse outcomes associated with interleukin-6 in patients recently hospitalized for heart failure with preserved ejection fraction. Circulation: Heart Failure, 16(4), e010051. (doi: 10.1161/CIRCHEARTFAILURE.122.010051) (PMID:36896709) (PMCID:PMC10101136)

Alexander, C., Bishop, M. J., Gilchrist, R. J., Burton, F. L., Smith, G. L. and Myles, R. C. (2023) Initiation of ventricular arrhythmia in the acquired long QT syndrome. Cardiovascular Research, 119(2), pp. 465-476. (doi: 10.1093/cvr/cvac103) (PMID:35727943) (PMCID:PMC10064840)

2022

Saxena, P., Myles, R. C. , Smith, G. L. and Workman, A. J. (2022) Adrenoceptor sub-type involvement in Ca2+ current stimulation by noradrenaline in human and rabbit atrial myocytes. Pflügers Archiv European Journal of Physiology, 474(12), pp. 1311-1321. (doi: 10.1007/s00424-022-02746-z) (PMID:36131146) (PMCID:PMC9663393)

Lachaud, Q., Aziz, M. H. N., Burton, F. L., Macquaide, N. , Myles, R. C. , Simitev, R. D. and Smith, G. L. (2022) Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes. Cardiovascular Research, 118(15), pp. 3112-3125. (doi: 10.1093/cvr/cvab375) (PMID:35020837) (PMCID:PMC9732512)

2021

Sveberg Dietrichs, E., Myles, R. and Smith, G. (2021) Is hypothermia more neuroprotective than avoiding fever after cardiac arrest? Cardiovascular Research, 117(12), e159-e161. (doi: 10.1093/cvr/cvab297) (PMID:34718465) (PMCID:PMC8562327)

Jabbour, R. J. et al. (2021) In vivo grafting of large engineered heart tissue patches for cardiac repair. JCI Insight, 6(15), e144068. (doi: 10.1172/jci.insight.144068) (PMID:34369384) (PMCID:PMC8410032)

Wang, L., Myles, R. C. , Lee, I.-J., Bers, D. M. and Ripplinger, C. M. (2021) Role of reduced sarco-endoplasmic reticulum Ca2+-ATPase function on sarcoplasmic reticulum Ca2+ alternans in the intact rabbit heart. Frontiers in Physiology, 12, 656516. (doi: 10.3389/fphys.2021.656516) (PMID:34045974) (PMCID:PMC8144333)

Dobbin, S. J.H. , Petrie, M. C. , Myles, R. C. , Touyz, R. M. and Lang, N. N. (2021) Cardiotoxic effects of angiogenesis inhibitors. Clinical Science, 135(1), pp. 71-100. (doi: 10.1042/CS20200305) (PMID:33404052) (PMCID:PMC7812690)

2020

Dietrichs, E. S., McGlynn, K., Allan, A., Connolly, A., Bishop, M., Burton, F., Kettlewell, S., Myles, R. , Tveita, T. and Smith, G. L. (2020) Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology. Cardiovascular Research, 116(13), pp. 2081-2090. (doi: 10.1093/cvr/cvz309) (PMID:32031595) (PMCID:PMC7584464)

Dietrichs, E. S., Tveita, T., Myles, R. and Smith, G. (2020) A novel ECG-biomarker for cardiac arrest during hypothermia. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 28, 27. (doi: 10.1186/s13049-020-00721-0) (PMID:32276599) (PMCID:PMC7149849)

2019

Wang, L. et al. (2019) Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts. Journal of Physiology, 597(15), pp. 3867-3883. (doi: 10.1113/jp278016) (PMID:31215643)

Kettlewell, S., Saxena, P., Dempster, J., Colman, M. A., Myles, R. C. , Smith, G. L. and Workman, A. J. (2019) Dynamic‐clamping human and rabbit atrial calcium current: narrowing ICaL window abolishes early afterdepolarisations. Journal of Physiology, 597(14), pp. 3619-3638. (doi: 10.1113/JP277827) (PMID:31093979) (PMCID:PMC6767690)

2018

Connolly, A., Kelly, A., Campos, F. O., Myles, R. , Smith, G. and Bishop, M. J. (2018) Ventricular endocardial tissue geometry affects stimulus threshold and effective refractory period. Biophysical Journal, 115(12), pp. 2486-2498. (doi: 10.1016/j.bpj.2018.11.003) (PMID:30503533) (PMCID:PMC6301915)

2017

Holman, R. R. et al. (2017) Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial. Lancet Diabetes and Endocrinology, 5(11), pp. 877-886. (doi: 10.1016/S2213-8587(17)30309-1) (PMID:28917545)

Murphy, S. R., Wang, L., Wang, Z., Domondon, P., Lang, D., Habecker, B. A., Myles, R. C. and Ripplinger, C. M. (2017) β-adrenergic inhibition prevents action potential and calcium handling changes during regional myocardial ischemia. Frontiers in Physiology, 8, 630. (doi: 10.3389/fphys.2017.00630) (PMID:28894423) (PMCID:PMC5581400)

2016

Gardner, R. T., Ripplinger, C. M., Myles, R. and Habecker, B. A. (2016) Molecular mechanisms of sympathetic remodeling and arrhythmias. Circulation: Arrhythmia and Electrophysiology, 9(2), e001359. (doi: 10.1161/circep.115.001359) (PMID:26810594) (PMCID:PMC4730917)

2015

Myles, R. C. , Wang, L., Bers, D. M. and Ripplinger, C. M. (2015) Decreased inward rectifying K+current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart. Journal of Physiology, 593(6), pp. 1479-1493. (doi: 10.1113/jphysiol.2014.279638) (PMID:25772297)

2014

Wang, L., Myles, R. C. , De Jesus, N. M., Ohlendorf, A. K.P., Bers, D. M. and Ripplinger, C. M. (2014) Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation. Circulation Research, 114(9), pp. 1410-1421. (doi: 10.1161/CIRCRESAHA.114.302505)

Jackson, C. E., Myles, R. C. and McMurray, J. J.V. (2014) Microvolt T-wave alternans testing in patients recently hospitalized with decompensated heart failure. European Journal of Heart Failure, 16(1), p. 113. (doi: 10.1111/ejhf.45) (PMID:24453101)

2013

Di Diego, J.M., Sicouri, S., Myles, R.C. , Burton, F., Smith, G.L. and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi: 10.1016/j.yjmcc.2012.10.017)

Jackson, C.E. et al. (2013) Feasibility/eligibility of T-wave alternans testing in patients with heart failure: should we rethink our current modus operandi?: reply. European Journal of Heart Failure, 14(6), pp. 676-677. (doi: 10.1093/eurjhf/hfs050)

Kelly, A., Ghouri, I.A., Kemi, O.J. , Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C. , Burton, F.L. and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi: 10.1161/CIRCEP.113.000334)

2012

Jackson, C.E., Myles, R.C. , Cobbe, S.M., Petrie, M.C. and McMurray, J.J.V. (2012) Microvolt T-wave alternans testing has no role at present in guiding therapy for patients at high risk of ventricular arrhythmias. Journal of the American College of Cardiology, 59(9), p. 856. (doi: 10.1016/j.jacc.2011.10.897)

Jackson, C.E. et al. (2012) Microvolt T-wave alternans (MTWA) testing in 'real world' heart failure (HF): a study of prevalence and incremental prognostic value. Heart, 2012(98), A12. (doi: 10.1136/heartjnl-2012-301877b.17)

Jackson, C.E. et al. (2012) Microvolt T-wave alternans testing should be used to guide arrhythmic therapy in heart failure patients: reply. European Journal of Heart Failure, 14(6), p. 678. (doi: 10.1093/eurjhf/hfs077)

Jackson, C.E. et al. (2012) Profile of microvolt T-wave alternans testing in 1003 patients hospitalized with heart failure. European Journal of Heart Failure, 14(4), pp. 377-386. (doi: 10.1093/eurjhf/hfs010)

Myles, R.C. , Wang, L., Kang, C., Bers, D.M. and Ripplinger, C.M. (2012) Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia. Circulation Research, 110(11), pp. 1454-1464. (doi: 10.1161/CIRCRESAHA.111.262345)

Seegers, J. et al. (2012) Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype. Europace, 14(3), pp. 416-422. (doi: 10.1093/europace/eur352)

2011

Myles, R. , Burton, F.L., Cobbe, S. and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi: 10.1016/j.yjmcc.2010.11.019)

2010

Myles, R.C. , Bernus, O., Burton, F.L., Cobbe, S.M. and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi: 10.1152/ajpheart.00518.2010)

2009

Jackson, C.E., Dalzell, J.R., Bezlyak, V., Tsorlalis, I.K., Myles, R.C., Spooner, R., Ford, I., Petrie, M.C., Cobbe, S. and McMurray, J.J. (2009) Red cell distribution width has incremental prognostic value to B-type natriuretic peptide in acute heart failure. European Journal of Heart Failure, 11(12), pp. 1152-1154. (doi: 10.1093/eurjhf/hfp157)

2008

Lang, N.N. , Myles, R.C., Burton, F.L., Hall, D.P., Chin, Y.Z., Boon, N.A. and Newby, D.E. (2008) The vascular effects of rotigaptide in vivo in man. Biochemical Pharmacology, 76(10), pp. 1194-1200. (doi: 10.1016/j.bcp.2008.08.022)

Myles, R.C. , Burton, F.L., Cobbe, S.M. and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi: 10.1016/j.yjmcc.2008.03.024)

This list was generated on Wed Nov 20 19:15:50 2024 GMT.
Jump to: Articles
Number of items: 36.

Articles

Shead, K. D., Huethorst, E. , Burton, F., Lang, N. , Myles, R. C. and Smith, G. L. (2024) Human induced pluripotent stem cell derived cardiomyocytes for pre-clinical cardiotoxicity screening. JACC: CardioOncology, (Accepted for Publication)

Freeman, M., Huethorst, E. , Boland, E., Dunne, M., Burton, F., Denning, C., Myles, R. and Smith, G. (2024) A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit. American Journal of Physiology: Heart and Circulatory Physiology, 326(3), H735--H751. (doi: 10.1152/ajpheart.00657.2023) (PMID:38180449)

Simitev, R. D. , Al dawoud, A., Aziz, M. H.N., Myles, R. and Smith, G. L. (2023) Phenomenological analysis of simple ion channel block in large populations of uncoupled cardiomyocytes. Mathematical Medicine and Biology, 40(2), pp. 175-198. (doi: 10.1093/imammb/dqad001) (PMID:36689769)

Mooney, L., Jackson, C. E., Adamson, C., McConnachie, A. , Welsh, P. , Myles, R. C. , McMurray, J. J.V. , Jhund, P. S. , Petrie, M. C. and Lang, N. N. (2023) Adverse outcomes associated with interleukin-6 in patients recently hospitalized for heart failure with preserved ejection fraction. Circulation: Heart Failure, 16(4), e010051. (doi: 10.1161/CIRCHEARTFAILURE.122.010051) (PMID:36896709) (PMCID:PMC10101136)

Alexander, C., Bishop, M. J., Gilchrist, R. J., Burton, F. L., Smith, G. L. and Myles, R. C. (2023) Initiation of ventricular arrhythmia in the acquired long QT syndrome. Cardiovascular Research, 119(2), pp. 465-476. (doi: 10.1093/cvr/cvac103) (PMID:35727943) (PMCID:PMC10064840)

Saxena, P., Myles, R. C. , Smith, G. L. and Workman, A. J. (2022) Adrenoceptor sub-type involvement in Ca2+ current stimulation by noradrenaline in human and rabbit atrial myocytes. Pflügers Archiv European Journal of Physiology, 474(12), pp. 1311-1321. (doi: 10.1007/s00424-022-02746-z) (PMID:36131146) (PMCID:PMC9663393)

Lachaud, Q., Aziz, M. H. N., Burton, F. L., Macquaide, N. , Myles, R. C. , Simitev, R. D. and Smith, G. L. (2022) Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes. Cardiovascular Research, 118(15), pp. 3112-3125. (doi: 10.1093/cvr/cvab375) (PMID:35020837) (PMCID:PMC9732512)

Sveberg Dietrichs, E., Myles, R. and Smith, G. (2021) Is hypothermia more neuroprotective than avoiding fever after cardiac arrest? Cardiovascular Research, 117(12), e159-e161. (doi: 10.1093/cvr/cvab297) (PMID:34718465) (PMCID:PMC8562327)

Jabbour, R. J. et al. (2021) In vivo grafting of large engineered heart tissue patches for cardiac repair. JCI Insight, 6(15), e144068. (doi: 10.1172/jci.insight.144068) (PMID:34369384) (PMCID:PMC8410032)

Wang, L., Myles, R. C. , Lee, I.-J., Bers, D. M. and Ripplinger, C. M. (2021) Role of reduced sarco-endoplasmic reticulum Ca2+-ATPase function on sarcoplasmic reticulum Ca2+ alternans in the intact rabbit heart. Frontiers in Physiology, 12, 656516. (doi: 10.3389/fphys.2021.656516) (PMID:34045974) (PMCID:PMC8144333)

Dobbin, S. J.H. , Petrie, M. C. , Myles, R. C. , Touyz, R. M. and Lang, N. N. (2021) Cardiotoxic effects of angiogenesis inhibitors. Clinical Science, 135(1), pp. 71-100. (doi: 10.1042/CS20200305) (PMID:33404052) (PMCID:PMC7812690)

Dietrichs, E. S., McGlynn, K., Allan, A., Connolly, A., Bishop, M., Burton, F., Kettlewell, S., Myles, R. , Tveita, T. and Smith, G. L. (2020) Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology. Cardiovascular Research, 116(13), pp. 2081-2090. (doi: 10.1093/cvr/cvz309) (PMID:32031595) (PMCID:PMC7584464)

Dietrichs, E. S., Tveita, T., Myles, R. and Smith, G. (2020) A novel ECG-biomarker for cardiac arrest during hypothermia. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 28, 27. (doi: 10.1186/s13049-020-00721-0) (PMID:32276599) (PMCID:PMC7149849)

Wang, L. et al. (2019) Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts. Journal of Physiology, 597(15), pp. 3867-3883. (doi: 10.1113/jp278016) (PMID:31215643)

Kettlewell, S., Saxena, P., Dempster, J., Colman, M. A., Myles, R. C. , Smith, G. L. and Workman, A. J. (2019) Dynamic‐clamping human and rabbit atrial calcium current: narrowing ICaL window abolishes early afterdepolarisations. Journal of Physiology, 597(14), pp. 3619-3638. (doi: 10.1113/JP277827) (PMID:31093979) (PMCID:PMC6767690)

Connolly, A., Kelly, A., Campos, F. O., Myles, R. , Smith, G. and Bishop, M. J. (2018) Ventricular endocardial tissue geometry affects stimulus threshold and effective refractory period. Biophysical Journal, 115(12), pp. 2486-2498. (doi: 10.1016/j.bpj.2018.11.003) (PMID:30503533) (PMCID:PMC6301915)

Holman, R. R. et al. (2017) Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial. Lancet Diabetes and Endocrinology, 5(11), pp. 877-886. (doi: 10.1016/S2213-8587(17)30309-1) (PMID:28917545)

Murphy, S. R., Wang, L., Wang, Z., Domondon, P., Lang, D., Habecker, B. A., Myles, R. C. and Ripplinger, C. M. (2017) β-adrenergic inhibition prevents action potential and calcium handling changes during regional myocardial ischemia. Frontiers in Physiology, 8, 630. (doi: 10.3389/fphys.2017.00630) (PMID:28894423) (PMCID:PMC5581400)

Gardner, R. T., Ripplinger, C. M., Myles, R. and Habecker, B. A. (2016) Molecular mechanisms of sympathetic remodeling and arrhythmias. Circulation: Arrhythmia and Electrophysiology, 9(2), e001359. (doi: 10.1161/circep.115.001359) (PMID:26810594) (PMCID:PMC4730917)

Myles, R. C. , Wang, L., Bers, D. M. and Ripplinger, C. M. (2015) Decreased inward rectifying K+current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart. Journal of Physiology, 593(6), pp. 1479-1493. (doi: 10.1113/jphysiol.2014.279638) (PMID:25772297)

Wang, L., Myles, R. C. , De Jesus, N. M., Ohlendorf, A. K.P., Bers, D. M. and Ripplinger, C. M. (2014) Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation. Circulation Research, 114(9), pp. 1410-1421. (doi: 10.1161/CIRCRESAHA.114.302505)

Jackson, C. E., Myles, R. C. and McMurray, J. J.V. (2014) Microvolt T-wave alternans testing in patients recently hospitalized with decompensated heart failure. European Journal of Heart Failure, 16(1), p. 113. (doi: 10.1111/ejhf.45) (PMID:24453101)

Di Diego, J.M., Sicouri, S., Myles, R.C. , Burton, F., Smith, G.L. and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi: 10.1016/j.yjmcc.2012.10.017)

Jackson, C.E. et al. (2013) Feasibility/eligibility of T-wave alternans testing in patients with heart failure: should we rethink our current modus operandi?: reply. European Journal of Heart Failure, 14(6), pp. 676-677. (doi: 10.1093/eurjhf/hfs050)

Kelly, A., Ghouri, I.A., Kemi, O.J. , Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C. , Burton, F.L. and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi: 10.1161/CIRCEP.113.000334)

Jackson, C.E., Myles, R.C. , Cobbe, S.M., Petrie, M.C. and McMurray, J.J.V. (2012) Microvolt T-wave alternans testing has no role at present in guiding therapy for patients at high risk of ventricular arrhythmias. Journal of the American College of Cardiology, 59(9), p. 856. (doi: 10.1016/j.jacc.2011.10.897)

Jackson, C.E. et al. (2012) Microvolt T-wave alternans (MTWA) testing in 'real world' heart failure (HF): a study of prevalence and incremental prognostic value. Heart, 2012(98), A12. (doi: 10.1136/heartjnl-2012-301877b.17)

Jackson, C.E. et al. (2012) Microvolt T-wave alternans testing should be used to guide arrhythmic therapy in heart failure patients: reply. European Journal of Heart Failure, 14(6), p. 678. (doi: 10.1093/eurjhf/hfs077)

Jackson, C.E. et al. (2012) Profile of microvolt T-wave alternans testing in 1003 patients hospitalized with heart failure. European Journal of Heart Failure, 14(4), pp. 377-386. (doi: 10.1093/eurjhf/hfs010)

Myles, R.C. , Wang, L., Kang, C., Bers, D.M. and Ripplinger, C.M. (2012) Local β-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia. Circulation Research, 110(11), pp. 1454-1464. (doi: 10.1161/CIRCRESAHA.111.262345)

Seegers, J. et al. (2012) Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype. Europace, 14(3), pp. 416-422. (doi: 10.1093/europace/eur352)

Myles, R. , Burton, F.L., Cobbe, S. and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi: 10.1016/j.yjmcc.2010.11.019)

Myles, R.C. , Bernus, O., Burton, F.L., Cobbe, S.M. and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi: 10.1152/ajpheart.00518.2010)

Jackson, C.E., Dalzell, J.R., Bezlyak, V., Tsorlalis, I.K., Myles, R.C., Spooner, R., Ford, I., Petrie, M.C., Cobbe, S. and McMurray, J.J. (2009) Red cell distribution width has incremental prognostic value to B-type natriuretic peptide in acute heart failure. European Journal of Heart Failure, 11(12), pp. 1152-1154. (doi: 10.1093/eurjhf/hfp157)

Lang, N.N. , Myles, R.C., Burton, F.L., Hall, D.P., Chin, Y.Z., Boon, N.A. and Newby, D.E. (2008) The vascular effects of rotigaptide in vivo in man. Biochemical Pharmacology, 76(10), pp. 1194-1200. (doi: 10.1016/j.bcp.2008.08.022)

Myles, R.C. , Burton, F.L., Cobbe, S.M. and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi: 10.1016/j.yjmcc.2008.03.024)

This list was generated on Wed Nov 20 19:15:50 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Cross disciplinary capacity building in ultra-high frequency preclinical cardiovascular ultrasound
    British Heart Foundation
    2022 - 2025
     
  • Correlative Optical investiagtion of cardiac Eletrophysiology Under Remodelling
    British Heart Foundation
    2022 - 2025
     
  • Pharmacological and dynamic-clamp narrowing of the calcium current window to inhibit human atrial early after depolarisations and atrial fibrillation.
    British Heart Foundation
    2021 - 2024
     
  • Adrenergic modulation of ventricular conduction velocity is a novel modulator of electrical excitability in health and disease
    British Heart Foundation
    2019 - 2022
     
  • Investigating the influence of myofibroblast coupling on cardiac conduction and infarct electrophysiology
    British Heart Foundation
    2017 - 2020
     
  • Adrenoceptor-subtype antagonism profiles with anti-arrhythmic potential in human atrial myocytes
    British Heart Foundation
    2017 - 2020
     
  • The role of sarcoplasmic reticulum calcium in the generation of early after-depolarisations and ventricular arrhythmias in the long QT syndrome
    British Heart Foundation
    2015 - 2018
     
  • Heterogeneity of sympathetic stimulation as a mechanism of ventricular arrhythmia following myocardial infarction
    Wellcome Trust
    2015 - 2020
     
  • Mechanisms of Early Afterdepolarisations in the Long QT Syndrome: A Study of Cellular Voltage and Calcium Dynamics in the Intact Heart
    Academy of Medical Sciences
    2013 - 2015
     
  • Electrophysiological remodelling and mechanisms of ventricular arrhythmia in dilated cardiomyopathy.
    British Heart Foundation
    2010 - 2011
     
  • Cellular basis for alternating T-wave morphology in isolated rabbit hearts
    British Heart Foundation
    2009 - 2012
     
  • Microvolt T-wave alternans in chronic heart failure: a study of prevalence and incremental prognostic value.
    Scottish Executive Health Department
    2007 - 2009
     
  • Microvolt T-wave alternans in chronic heart failure: a study of prevalence and incremental prognostic value.
    NHS Endowment Funds
    2007 - 2008
     
  • The role of repolarisation alternans in ventricular arrhythmia in a rabbit model of heart failure
    British Heart Foundation
    2006 - 2009
     

Supervision

  • Dickson-Murray, Eleanor
    Palmitoylation and the regulation of the cardiac transient outward current
  • Shead, Kyle
    Use of IPSCs as a novel platform to screen for cardiotoxicity in anti-cancer therapies

Research datasets

Jump to: 2023
Number of items: 1.

2023

Simitev, R. D. , Al dawoud, A. M. A., Aziz, M. H. N., Myles, R. and Smith, G. (2023) Phenomenological analysis of simple ion channel block in large populations of uncoupled cardiomyocytes. [Data Collection]

This list was generated on Wed Nov 20 23:21:38 2024 GMT.

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