Professor Niall Macfarlane
- Professor in Physiology and Sports Science (Cardiovascular & Metabolic Health)
telephone:
01413305965
email:
Niall.MacFarlane@glasgow.ac.uk
R240A Level 2, LS Human Biology /Sports Science, Sir James Black Building, Glasgow G12 8QQ
Research interests
Research Interests
- Physiological demands of exercise
- human performance in elite athletes and elite team sports
- muscle adaptation and training interventions
Publications
2024
Zou, Y. and MacFarlane, N. (2024) Influence of biceps-triceps ratio on golf swing performance. PLoS ONE, 19(7), e0307547. (doi: 10.1371/journal.pone.0307547) (PMID:39042614)
Carpels, T., Scobie, N. , MacFarlane, N. G. and Kemi, O. J. (2024) Mind the gap: comparison of external load and load variation between a reserve team in a 1-game week microcycle and its first team in a 2-game week microcycle within an elite professional soccer club. Journal of Strength and Conditioning Research, 38(5), e235-e242. (doi: 10.1519/JSC.0000000000004734) (PMID:38517476)
Kemi, O. J. , Penpraze, V., Scobie, N. and MacFarlane, N. G. (2024) Graduate prospects explain undergraduate program standing in university league sports science tables. Advances in Physiology Education, (doi: 10.1152/advan.00126.2023) (PMID:38420665) (In Press)
2023
Maughan, P. C., MacFarlane, N. G., Towlson, C., Barrett, S. and Swinton, P. A. (2023) Does transforming subjective measures of load better represent training and match-play intensity in youth soccer players? International Journal of Sports Science and Coaching, 18(5), pp. 1541-1549. (doi: 10.1177/17479541221114739)
2022
Guard, A., McMillan, K. and MacFarlane, N. (2022) Influence of game format and team strategy on physical and perceptual intensity in soccer small-sided games. International Journal of Sports Science and Coaching, 17(5), pp. 1109-1118. (doi: 10.1177/17479541211056399)
Towlson, C. et al. (2022) The effect of bio-banding on technical and tactical indicators of talent identification in academy soccer players. Science and Medicine in Football, 6(3), pp. 295-308. (doi: 10.1080/24733938.2021.2013522) (PMID:35862161)
Guard, A. N., McMillan, K. and MacFarlane, N. G. (2022) The influence of relative playing area and player numerical imbalance on physical and perceptual demands in soccer small-sided game formats. Science and Medicine in Football, 6(2), pp. 221-227. (doi: 10.1080/24733938.2021.1939408) (PMID:35475753)
2021
Maughan, P. C., MacFarlane, N. G. and Swinton, P. A. (2021) Quantification of training and match-play load across a season in professional youth football players. International Journal of Sports Science and Coaching, 16(5), pp. 1169-1177. (doi: 10.1177/17479541211000328)
Maughan, P. C., MacFarlane, N. G. and Swinton, P. A. (2021) Relationship between subjective and external training load variables in youth soccer players. International Journal of Sports Physiology and Performance, 16(8), pp. 1127-1133. (doi: 10.1123/ijspp.2019-0956) (PMID:33607628)
Maughan, P., Swinton, P. and MacFarlane, N. (2021) Relationships between training load variables in professional youth football players. International Journal of Sports Medicine, 42(7), pp. 624-629. (doi: 10.1055/a-1300-2959) (PMID:33260250)
Carpels, T., Scobie, N. , MacFarlane, N. G. and Kemi, O. J. (2021) Youth-to-senior transition in elite European club soccer. International Journal of Exercise Science, 14(6), pp. 1192-1203. (PMID:35096247) (PMCID:PMC8758176)
Tollan, C. J., MacFarlane, N. G. and MacKay, I. R. (2021) High cut-off microdialysis catheters to clinically investigate cytokine changes following flap transfer. European Journal of Plastic Surgery, 44, pp. 483-492. (doi: 10.1007/s00238-020-01778-x)
Towlson, C. et al. (2021) The effect of bio-banding on physical and psychological indicators of talent identification in academy soccer players. Science and Medicine in Football, 5(4), pp. 280-292. (doi: 10.1080/24733938.2020.1862419)
2019
Barclay, A., Paul, L., MacFarlane, N. and McFadyen, A. (2019) The effect of cycling using active-passive trainers on spasticity, cardiovascular fitness, function and quality of life in people with moderate to severe Multiple Sclerosis (MS); a feasibility study. Multiple Sclerosis and Related Disorders, 34, pp. 128-134. (doi: 10.1016/j.msard.2019.06.019)
2018
Awede, B., Adovoekpe, D., Adehan, G., MacFarlane, N. G., Azonbakin, S., Dossou, E., Amoussou-Guenou, M. and Djrolo, F. (2018) Adiponectin, in contrast to leptin, is not associated with body mass index, waist circumference and HOMA-IR in subjects of a west-African population. Physiological Reports, 6(11), e13718. (doi: 10.14814/phy2.13718)
MacFarlane, N. G. (2018) Digestion and absorption. Anaesthesia and Intensive Care Medicine, 19(3), pp. 125-127. (doi: 10.1016/j.mpaic.2018.01.001)
MacFarlane, N. G. (2018) Gut motility and its control. Anaesthesia and Intensive Care Medicine, 19(3), pp. 133-135. (doi: 10.1016/j.mpaic.2018.01.002)
McDonald, S. W. and MacFarlane, N. G. (2018) The mouth, stomach and intestines. Anaesthesia and Intensive Care Medicine, 19(3), pp. 128-132. (doi: 10.1016/j.mpaic.2018.01.003)
2015
White, A. D. and MacFarlane, N. G. (2015) Contextual effects on activity profiles of domestic field hockey during competition and training. Human Movement Science, 40, pp. 422-431. (doi: 10.1016/j.humov.2015.01.007) (PMID:25697973)
White, A. D. and MacFarlane, N. G. (2015) Analysis of international competition and training in menʼs field hockey by global positioning system and inertial sensor technology. Journal of Strength and Conditioning Research, 29(1), pp. 137-143. (doi: 10.1519/JSC.0000000000000600)
2014
Learmonth, Y. C., Paul, L., McFadyen, A. K., Marshall-Mckenna, R. , Mattison, P., Miller, L. and MacFarlane, N. G. (2014) Short-term effect of aerobic exercise on symptoms in multiple sclerosis and chronic fatigue syndrome. International Journal of MS Care, 16(2), pp. 76-82. (doi: 10.7224/1537-2073.2013-005) (PMID:25061431) (PMCID:PMC4106394)
2013
White, A.D. and MacFarlane, N. (2013) Time-on-pitch or full-game GPS analysis procedures for elite field hockey? International Journal of Sports Physiology and Performance, 8(5), pp. 549-55.
Johnston, R. D., Gibson, N. V., Twist, C., Gabbett, T. J., MacNay, S. A. and MacFarlane, N. G. (2013) Physiological responses to an intensified period of rugby league competition. Journal of Strength and Conditioning Research, 27(3), pp. 643-654. (doi: 10.1519/JSC.0b013e31825bb469) (PMID:22592168)
2010
Hall, L.M.L., Moran, C.N., Milne, G.R., MacFarlane, N.G., Forouhi, N.G., Hariharan, N., Salt, I.P. , Sattar, N. and Gill, J.M.R. (2010) Fat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance? PLoS ONE, 5(12), e14197. (doi: 10.1371/journal.pone.0014197) (PMID:21152018) (PMCID:PMC2995737)
2008
Newell, M., Newell, J., Grant, S. and MacFarlane, N. (2008) Fluid and electrolyte balance in elite gaelic football players. Irish Medical Journal, 101(8), pp. 236-9.
2007
Busquets, X., MacFarlane, N. G., Heine-Suñer, D., Morlá, M., Torres-Juan, L., Iglesias, A., Lladó, J., Sauleda, J. and Agustí, A. G.N. (2007) Angiotensin-converting-enzyme gene polymorphisms, smoking and chronic obstructive pulmonary disease. International Journal of COPD, 2(3), pp. 329-334. (PMID:18229571) (PMCID:PMC2695206)
McEntegart, M., Awede, B., Petrie, M. , Sattar, N., Dunn, F., MacFarlane, N. and McMurray, J. (2007) Increase in serum adiponectin concentration in patients with heart failure and cachexia: relationship with leptin, other cytokines, and B-type natriuretic peptide. European Heart Journal, 28, pp. 829-835. (doi: 10.1093/eurheartj/ehm033)
2006
Scott, S., Fuld, J., Carter, R., McEntegart, M. and MacFarlane, N. (2006) Diaphragm ultrasonography as an alternative to whole-body plethysmography in pulmonary function testing. Journal of Ultrasound in Medicine, 25, pp. 225-232.
2004
Miller, D., MacFarlane, N. and Wilson, G. (2004) Altered oscillatory work by ventricular myofilaments from a rabbit coronary artery ligation model of heart failure. Cardiovascular Research, 61, pp. 94-104. (doi: 10.1016/j.cardiores.2003.09.032)
2001
Darnley, G.M., Duke, A.M., Steele, D.S. and MacFarlane, N.G. (2001) Effects of reactive oxygen species on aspects of excitation-contraction coupling in chemically skinned rabbit diaphragm muscle fibres. Experimental Physiology, 86(2), pp. 161-168. (doi: 10.1113/eph8602109) (PMID:11429630)
Caruana, L., Petrie, M. C. , McMurray, J. j. and MacFarlane, N. G. (2001) Altered diaphragm position and function in patients with chronic heart failure. European Journal of Heart Failure, 3(2), pp. 183-187. (doi: 10.1016/S1388-9842(00)00133-1) (PMID:11246055)
2000
MacFarlane, N., Darnley, G.M. and Smith, G.L. (2000) Cellular basis for contractile dysfunction in the diaphragm from a rabbit infarct model of heart failure. American Journal of Physiology: Cell Physiology, 278(4), C739-C746. (PMID:10751323)
1999
Darnley, G. M., Gray, A. C., McClure, S. J., Neary, P., Petrie, M. , McMurray, J. J.V. and MacFarlane, N. G. (1999) Effects of resistive breathing on exercise capacity and diaphragm function in patients with ischaemic heart disease. European Journal of Heart Failure, 1(3), pp. 297-300. (doi: 10.1016/s1388-9842(99)00027-6) (PMID:10935679)
MacFarlane, N., Takahashi, S., Wilson, G., Okabe, E. and Miller, D.J. (1999) Effects of reactive oxygen species on myofilament function in a rabbit coronary artery ligation model of heart failure. Pflügers Archiv European Journal of Physiology, 438(3), pp. 289-98. (doi: 10.1007/s004240050912) (PMID:10398858)
1998
Denvir, M.A., MacFarlane, N.G., Miller, D.J. and Cobbe, S.M. (1998) Effects of cyclic adenosine monophosphate (cAMP) on sarcoplasmic reticulum Ca 2+ -loading in failing rabbit and human cardiac trabeculae. Basic Research in Cardiology, 93(5), pp. 396-404. (doi: 10.1007/s003950050108) (PMID:9833152)
Denvir, M.A., MacFarlane, N., Cobbe, S.M. and Miller, D.J. (1998) Sarcoplasmic reticulum Ca2+ loading in rabbits 8 and 15 weeks after coronary artery ligation. Pflügers Archiv European Journal of Physiology, 436(3), pp. 436-442. (doi: 10.1007/s004240050654) (PMID:9644227)
Takahashi, S.-s., Denvir, M. A., Harder, L., Miller, D. J., Cobbe, S., Kawakami, M., MacFarlane, N. G. and Okabe, E. (1998) Effects of in vitro and in vivo exposure to doxorubicin (Adriamycin) on caffeine-induced Ca2+ release from sarcoplasmic reticulum and contractile protein function in 'chemically-skinned' rabbit ventricular trabeculae. Japanese Journal of Pharmacology, 76(4), pp. 405-413. (doi: 10.1254/jjp.76.405) (PMID:9623719)
1997
Clark, A.L., Galloway, S., MacFarlane, N., Henderson, E., Aitchison, T. and McMurray, J.J.V. (1997) Catecholamines contribute to exertional dyspnoea and to the ventilatory response to exercise in normal humans. European Heart Journal, 18(11), pp. 1829-33. (doi: 10.1093/oxfordjournals.eurheartj.a015179) (PMID:9402459)
1996
Denvir, M.A., MacFarlane, N., Miller, D.J. and Cobbe, S. (1996) Enhanced SR function in saponin-treated ventricular trabeculae from rabbits with heart failure. American Journal of Physiology, 271(3 Pt 2), H850-H859. (PMID:8853317)
1995
Denvir, M.A., MacFarlane, N.G., Cobbe, S.M. and Miller, D.J. (1995) Sarcoplasmic reticulum and myofilament function in chemically-treated ventricular trabeculae from patients with heart failure. Cardiovascular Research, 30(3), pp. 377-385. (doi: 10.1016/S0008-6363(95)00056-9) (PMID:7585829)
Miller, D. J. and MacFarlane, N. G. (1995) Intracellular effects of free radicals and reactive oxygen species in cardiac muscle. Journal of Human Hypertension, 9(6), pp. 465-73. (PMID:7473529)
1994
MacFarlane, N.G., Miller, D.J., Smith, G.L. and Steele, D.S. (1994) Effects of oxidants on the sarcoplasmic reticulum of saponin treated rat ventricular trabeculae. Cardiovascular Research, 28(11), pp. 1647-1652. (doi: 10.1093/cvr/28.11.1647) (PMID:7842458)
Ray, S.G., McCann, G., Henderson, E., MacFarlane, N., Christie, J., Norrie, J., Ford, I. , Grant, S. and Dargie, H.J. (1994) Cardiorespiratory and symptomatic variables during maximal and submaximal exercise in men with stable effort angina: a comparison of atenolol and celiprolol. European Heart Journal, 15(11), pp. 1566-1570. (doi: 10.1093/oxfordjournals.eurheartj.a060431) (PMID:7835373)
Rowland, T.W., Unnithan, V.B., MacFarlane, N., Gibson, N.G. and Paton, J.Y. (1994) Clinical manifestations of the ‘athlete's heart’ in prepubertal male runners. International Journal of Sports Medicine, 15(8), pp. 515-519. (doi: 10.1055/s-2007-1021097)
MacFarlane, N. G. and Miller, D. J. (1994) Effects of the reactive oxygen species hypochlorous acid and hydrogen peroxide on force production and calcium sensitivity of rat cardiac myofilaments. Pflügers Archiv, 428(5-6), pp. 561-568. (doi: 10.1007/BF00374578) (PMID:7838678)
1992
O'Dowd, A., O'Dowd, J.J., O'Dowd, J.J., MacFarlane, N., Abe, H. and Miller, D.J. (1992) Analysis of novel imidazoles from isolated perfused rabbit heart by two high-performance liquid chromatographic methods. Journal of Chromatography B: Biomedical Sciences and Applications, 577(2), pp. 347-53. (doi: 10.1016/0378-4347(92)80257-Q) (PMID:1400766)
Northridge, D. B., Jamieson, M. P., Jardine, A. G. , MacArthur, K. J.D., MacFarlane, N. and Dargie, H. J. (1992) Pulmonary extraction and left atrial secretion of atrial natriuretic factor during cardiopulmonary bypass surgery. American Heart Journal, 123(3), pp. 698-703. (doi: 10.1016/0002-8703(92)90509-T) (PMID:1531724)
MacFarlane, N.G. and Miller, D.J. (1992) Depression of peak force without altering calcium sensitivity by the superoxide anion in chemically skinned cardiac muscle of rat. Circulation Research, 70(6), pp. 1217-1224. (doi: 10.1161/01.RES.70.6.1217) (PMID:1315636)
1991
MacFarlane, N., McMurray, J. , O'Dowd, J. J., Dargie, H. J. and Miller, D. J. (1991) Synergism of histidyl dipeptides as antioxidants. Journal of Molecular and Cellular Cardiology, 23(11), pp. 1205-1207. (doi: 10.1016/0022-2828(91)90077-Y) (PMID:1803015)
MacFarlane, N., Northridge, D.B., Wright, A.R., Grant, S. and Dargie, H.J. (1991) A comparative study of left ventricular structure and function in elite athletes. British Journal of Sports Medicine, 25(1), pp. 45-48. (doi: 10.1136/bjsm.25.1.45) (PMID:1833026) (PMCID:PMC1478796)
1990
MacFarlane, N. (1990) Serum creatine kinase activity in myocardial infarction. Journal of Cardiovascular Technology, 5(2), pp. 64-68.
1989
MacFarlane, N. (1989) Psychogenic hypertension: fact or fiction. Journal of Cardiovascular Technology, 4(3), pp. 125-128.
Articles
Zou, Y. and MacFarlane, N. (2024) Influence of biceps-triceps ratio on golf swing performance. PLoS ONE, 19(7), e0307547. (doi: 10.1371/journal.pone.0307547) (PMID:39042614)
Carpels, T., Scobie, N. , MacFarlane, N. G. and Kemi, O. J. (2024) Mind the gap: comparison of external load and load variation between a reserve team in a 1-game week microcycle and its first team in a 2-game week microcycle within an elite professional soccer club. Journal of Strength and Conditioning Research, 38(5), e235-e242. (doi: 10.1519/JSC.0000000000004734) (PMID:38517476)
Kemi, O. J. , Penpraze, V., Scobie, N. and MacFarlane, N. G. (2024) Graduate prospects explain undergraduate program standing in university league sports science tables. Advances in Physiology Education, (doi: 10.1152/advan.00126.2023) (PMID:38420665) (In Press)
Maughan, P. C., MacFarlane, N. G., Towlson, C., Barrett, S. and Swinton, P. A. (2023) Does transforming subjective measures of load better represent training and match-play intensity in youth soccer players? International Journal of Sports Science and Coaching, 18(5), pp. 1541-1549. (doi: 10.1177/17479541221114739)
Guard, A., McMillan, K. and MacFarlane, N. (2022) Influence of game format and team strategy on physical and perceptual intensity in soccer small-sided games. International Journal of Sports Science and Coaching, 17(5), pp. 1109-1118. (doi: 10.1177/17479541211056399)
Towlson, C. et al. (2022) The effect of bio-banding on technical and tactical indicators of talent identification in academy soccer players. Science and Medicine in Football, 6(3), pp. 295-308. (doi: 10.1080/24733938.2021.2013522) (PMID:35862161)
Guard, A. N., McMillan, K. and MacFarlane, N. G. (2022) The influence of relative playing area and player numerical imbalance on physical and perceptual demands in soccer small-sided game formats. Science and Medicine in Football, 6(2), pp. 221-227. (doi: 10.1080/24733938.2021.1939408) (PMID:35475753)
Maughan, P. C., MacFarlane, N. G. and Swinton, P. A. (2021) Quantification of training and match-play load across a season in professional youth football players. International Journal of Sports Science and Coaching, 16(5), pp. 1169-1177. (doi: 10.1177/17479541211000328)
Maughan, P. C., MacFarlane, N. G. and Swinton, P. A. (2021) Relationship between subjective and external training load variables in youth soccer players. International Journal of Sports Physiology and Performance, 16(8), pp. 1127-1133. (doi: 10.1123/ijspp.2019-0956) (PMID:33607628)
Maughan, P., Swinton, P. and MacFarlane, N. (2021) Relationships between training load variables in professional youth football players. International Journal of Sports Medicine, 42(7), pp. 624-629. (doi: 10.1055/a-1300-2959) (PMID:33260250)
Carpels, T., Scobie, N. , MacFarlane, N. G. and Kemi, O. J. (2021) Youth-to-senior transition in elite European club soccer. International Journal of Exercise Science, 14(6), pp. 1192-1203. (PMID:35096247) (PMCID:PMC8758176)
Tollan, C. J., MacFarlane, N. G. and MacKay, I. R. (2021) High cut-off microdialysis catheters to clinically investigate cytokine changes following flap transfer. European Journal of Plastic Surgery, 44, pp. 483-492. (doi: 10.1007/s00238-020-01778-x)
Towlson, C. et al. (2021) The effect of bio-banding on physical and psychological indicators of talent identification in academy soccer players. Science and Medicine in Football, 5(4), pp. 280-292. (doi: 10.1080/24733938.2020.1862419)
Barclay, A., Paul, L., MacFarlane, N. and McFadyen, A. (2019) The effect of cycling using active-passive trainers on spasticity, cardiovascular fitness, function and quality of life in people with moderate to severe Multiple Sclerosis (MS); a feasibility study. Multiple Sclerosis and Related Disorders, 34, pp. 128-134. (doi: 10.1016/j.msard.2019.06.019)
Awede, B., Adovoekpe, D., Adehan, G., MacFarlane, N. G., Azonbakin, S., Dossou, E., Amoussou-Guenou, M. and Djrolo, F. (2018) Adiponectin, in contrast to leptin, is not associated with body mass index, waist circumference and HOMA-IR in subjects of a west-African population. Physiological Reports, 6(11), e13718. (doi: 10.14814/phy2.13718)
MacFarlane, N. G. (2018) Digestion and absorption. Anaesthesia and Intensive Care Medicine, 19(3), pp. 125-127. (doi: 10.1016/j.mpaic.2018.01.001)
MacFarlane, N. G. (2018) Gut motility and its control. Anaesthesia and Intensive Care Medicine, 19(3), pp. 133-135. (doi: 10.1016/j.mpaic.2018.01.002)
McDonald, S. W. and MacFarlane, N. G. (2018) The mouth, stomach and intestines. Anaesthesia and Intensive Care Medicine, 19(3), pp. 128-132. (doi: 10.1016/j.mpaic.2018.01.003)
White, A. D. and MacFarlane, N. G. (2015) Contextual effects on activity profiles of domestic field hockey during competition and training. Human Movement Science, 40, pp. 422-431. (doi: 10.1016/j.humov.2015.01.007) (PMID:25697973)
White, A. D. and MacFarlane, N. G. (2015) Analysis of international competition and training in menʼs field hockey by global positioning system and inertial sensor technology. Journal of Strength and Conditioning Research, 29(1), pp. 137-143. (doi: 10.1519/JSC.0000000000000600)
Learmonth, Y. C., Paul, L., McFadyen, A. K., Marshall-Mckenna, R. , Mattison, P., Miller, L. and MacFarlane, N. G. (2014) Short-term effect of aerobic exercise on symptoms in multiple sclerosis and chronic fatigue syndrome. International Journal of MS Care, 16(2), pp. 76-82. (doi: 10.7224/1537-2073.2013-005) (PMID:25061431) (PMCID:PMC4106394)
White, A.D. and MacFarlane, N. (2013) Time-on-pitch or full-game GPS analysis procedures for elite field hockey? International Journal of Sports Physiology and Performance, 8(5), pp. 549-55.
Johnston, R. D., Gibson, N. V., Twist, C., Gabbett, T. J., MacNay, S. A. and MacFarlane, N. G. (2013) Physiological responses to an intensified period of rugby league competition. Journal of Strength and Conditioning Research, 27(3), pp. 643-654. (doi: 10.1519/JSC.0b013e31825bb469) (PMID:22592168)
Hall, L.M.L., Moran, C.N., Milne, G.R., MacFarlane, N.G., Forouhi, N.G., Hariharan, N., Salt, I.P. , Sattar, N. and Gill, J.M.R. (2010) Fat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance? PLoS ONE, 5(12), e14197. (doi: 10.1371/journal.pone.0014197) (PMID:21152018) (PMCID:PMC2995737)
Newell, M., Newell, J., Grant, S. and MacFarlane, N. (2008) Fluid and electrolyte balance in elite gaelic football players. Irish Medical Journal, 101(8), pp. 236-9.
Busquets, X., MacFarlane, N. G., Heine-Suñer, D., Morlá, M., Torres-Juan, L., Iglesias, A., Lladó, J., Sauleda, J. and Agustí, A. G.N. (2007) Angiotensin-converting-enzyme gene polymorphisms, smoking and chronic obstructive pulmonary disease. International Journal of COPD, 2(3), pp. 329-334. (PMID:18229571) (PMCID:PMC2695206)
McEntegart, M., Awede, B., Petrie, M. , Sattar, N., Dunn, F., MacFarlane, N. and McMurray, J. (2007) Increase in serum adiponectin concentration in patients with heart failure and cachexia: relationship with leptin, other cytokines, and B-type natriuretic peptide. European Heart Journal, 28, pp. 829-835. (doi: 10.1093/eurheartj/ehm033)
Scott, S., Fuld, J., Carter, R., McEntegart, M. and MacFarlane, N. (2006) Diaphragm ultrasonography as an alternative to whole-body plethysmography in pulmonary function testing. Journal of Ultrasound in Medicine, 25, pp. 225-232.
Miller, D., MacFarlane, N. and Wilson, G. (2004) Altered oscillatory work by ventricular myofilaments from a rabbit coronary artery ligation model of heart failure. Cardiovascular Research, 61, pp. 94-104. (doi: 10.1016/j.cardiores.2003.09.032)
Darnley, G.M., Duke, A.M., Steele, D.S. and MacFarlane, N.G. (2001) Effects of reactive oxygen species on aspects of excitation-contraction coupling in chemically skinned rabbit diaphragm muscle fibres. Experimental Physiology, 86(2), pp. 161-168. (doi: 10.1113/eph8602109) (PMID:11429630)
Caruana, L., Petrie, M. C. , McMurray, J. j. and MacFarlane, N. G. (2001) Altered diaphragm position and function in patients with chronic heart failure. European Journal of Heart Failure, 3(2), pp. 183-187. (doi: 10.1016/S1388-9842(00)00133-1) (PMID:11246055)
MacFarlane, N., Darnley, G.M. and Smith, G.L. (2000) Cellular basis for contractile dysfunction in the diaphragm from a rabbit infarct model of heart failure. American Journal of Physiology: Cell Physiology, 278(4), C739-C746. (PMID:10751323)
Darnley, G. M., Gray, A. C., McClure, S. J., Neary, P., Petrie, M. , McMurray, J. J.V. and MacFarlane, N. G. (1999) Effects of resistive breathing on exercise capacity and diaphragm function in patients with ischaemic heart disease. European Journal of Heart Failure, 1(3), pp. 297-300. (doi: 10.1016/s1388-9842(99)00027-6) (PMID:10935679)
MacFarlane, N., Takahashi, S., Wilson, G., Okabe, E. and Miller, D.J. (1999) Effects of reactive oxygen species on myofilament function in a rabbit coronary artery ligation model of heart failure. Pflügers Archiv European Journal of Physiology, 438(3), pp. 289-98. (doi: 10.1007/s004240050912) (PMID:10398858)
Denvir, M.A., MacFarlane, N.G., Miller, D.J. and Cobbe, S.M. (1998) Effects of cyclic adenosine monophosphate (cAMP) on sarcoplasmic reticulum Ca 2+ -loading in failing rabbit and human cardiac trabeculae. Basic Research in Cardiology, 93(5), pp. 396-404. (doi: 10.1007/s003950050108) (PMID:9833152)
Denvir, M.A., MacFarlane, N., Cobbe, S.M. and Miller, D.J. (1998) Sarcoplasmic reticulum Ca2+ loading in rabbits 8 and 15 weeks after coronary artery ligation. Pflügers Archiv European Journal of Physiology, 436(3), pp. 436-442. (doi: 10.1007/s004240050654) (PMID:9644227)
Takahashi, S.-s., Denvir, M. A., Harder, L., Miller, D. J., Cobbe, S., Kawakami, M., MacFarlane, N. G. and Okabe, E. (1998) Effects of in vitro and in vivo exposure to doxorubicin (Adriamycin) on caffeine-induced Ca2+ release from sarcoplasmic reticulum and contractile protein function in 'chemically-skinned' rabbit ventricular trabeculae. Japanese Journal of Pharmacology, 76(4), pp. 405-413. (doi: 10.1254/jjp.76.405) (PMID:9623719)
Clark, A.L., Galloway, S., MacFarlane, N., Henderson, E., Aitchison, T. and McMurray, J.J.V. (1997) Catecholamines contribute to exertional dyspnoea and to the ventilatory response to exercise in normal humans. European Heart Journal, 18(11), pp. 1829-33. (doi: 10.1093/oxfordjournals.eurheartj.a015179) (PMID:9402459)
Denvir, M.A., MacFarlane, N., Miller, D.J. and Cobbe, S. (1996) Enhanced SR function in saponin-treated ventricular trabeculae from rabbits with heart failure. American Journal of Physiology, 271(3 Pt 2), H850-H859. (PMID:8853317)
Denvir, M.A., MacFarlane, N.G., Cobbe, S.M. and Miller, D.J. (1995) Sarcoplasmic reticulum and myofilament function in chemically-treated ventricular trabeculae from patients with heart failure. Cardiovascular Research, 30(3), pp. 377-385. (doi: 10.1016/S0008-6363(95)00056-9) (PMID:7585829)
Miller, D. J. and MacFarlane, N. G. (1995) Intracellular effects of free radicals and reactive oxygen species in cardiac muscle. Journal of Human Hypertension, 9(6), pp. 465-73. (PMID:7473529)
MacFarlane, N.G., Miller, D.J., Smith, G.L. and Steele, D.S. (1994) Effects of oxidants on the sarcoplasmic reticulum of saponin treated rat ventricular trabeculae. Cardiovascular Research, 28(11), pp. 1647-1652. (doi: 10.1093/cvr/28.11.1647) (PMID:7842458)
Ray, S.G., McCann, G., Henderson, E., MacFarlane, N., Christie, J., Norrie, J., Ford, I. , Grant, S. and Dargie, H.J. (1994) Cardiorespiratory and symptomatic variables during maximal and submaximal exercise in men with stable effort angina: a comparison of atenolol and celiprolol. European Heart Journal, 15(11), pp. 1566-1570. (doi: 10.1093/oxfordjournals.eurheartj.a060431) (PMID:7835373)
Rowland, T.W., Unnithan, V.B., MacFarlane, N., Gibson, N.G. and Paton, J.Y. (1994) Clinical manifestations of the ‘athlete's heart’ in prepubertal male runners. International Journal of Sports Medicine, 15(8), pp. 515-519. (doi: 10.1055/s-2007-1021097)
MacFarlane, N. G. and Miller, D. J. (1994) Effects of the reactive oxygen species hypochlorous acid and hydrogen peroxide on force production and calcium sensitivity of rat cardiac myofilaments. Pflügers Archiv, 428(5-6), pp. 561-568. (doi: 10.1007/BF00374578) (PMID:7838678)
O'Dowd, A., O'Dowd, J.J., O'Dowd, J.J., MacFarlane, N., Abe, H. and Miller, D.J. (1992) Analysis of novel imidazoles from isolated perfused rabbit heart by two high-performance liquid chromatographic methods. Journal of Chromatography B: Biomedical Sciences and Applications, 577(2), pp. 347-53. (doi: 10.1016/0378-4347(92)80257-Q) (PMID:1400766)
Northridge, D. B., Jamieson, M. P., Jardine, A. G. , MacArthur, K. J.D., MacFarlane, N. and Dargie, H. J. (1992) Pulmonary extraction and left atrial secretion of atrial natriuretic factor during cardiopulmonary bypass surgery. American Heart Journal, 123(3), pp. 698-703. (doi: 10.1016/0002-8703(92)90509-T) (PMID:1531724)
MacFarlane, N.G. and Miller, D.J. (1992) Depression of peak force without altering calcium sensitivity by the superoxide anion in chemically skinned cardiac muscle of rat. Circulation Research, 70(6), pp. 1217-1224. (doi: 10.1161/01.RES.70.6.1217) (PMID:1315636)
MacFarlane, N., McMurray, J. , O'Dowd, J. J., Dargie, H. J. and Miller, D. J. (1991) Synergism of histidyl dipeptides as antioxidants. Journal of Molecular and Cellular Cardiology, 23(11), pp. 1205-1207. (doi: 10.1016/0022-2828(91)90077-Y) (PMID:1803015)
MacFarlane, N., Northridge, D.B., Wright, A.R., Grant, S. and Dargie, H.J. (1991) A comparative study of left ventricular structure and function in elite athletes. British Journal of Sports Medicine, 25(1), pp. 45-48. (doi: 10.1136/bjsm.25.1.45) (PMID:1833026) (PMCID:PMC1478796)
MacFarlane, N. (1990) Serum creatine kinase activity in myocardial infarction. Journal of Cardiovascular Technology, 5(2), pp. 64-68.
MacFarlane, N. (1989) Psychogenic hypertension: fact or fiction. Journal of Cardiovascular Technology, 4(3), pp. 125-128.
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Impaired skeletal muscle oxidative capacity as a mechanism for greater insulin resistance in South Asians?
Diabetes UK
2006 - 2009
- Muscle wasting in chronic heart failure - a role for cyclin-dependent kinase inhibitors
British Heart Foundation
2003 - 2005
Additional information
Grant Advisory Board
- 2006 - present: Scottish Football Association - Working party on sports science
Invited International Presentations
- 2005: Edinburgh, Scotland - Inaugural plenary lecture 1st Edinburgh Festival for Sports Science
Professional Learned Society
- 2001 - present: Pharmacological Society
- 1997 - present: International Society for Heart Research
- 1995 - present: British Society for Cardiovascular Research
- 1993 - present: Physiological Society - Joint with British Pharmacological Society, working party on integrative mammalian biology, from 2006. Animal welfare and legislation working group, from 2006. Joint Committee on In Vivo Training, 2000 ongoing
Research Fellowship
- 1995 - 1998: British Heart Foundation Fellowship