Dr Laura Dowsett

  • Research Fellow (Cardiovascular & Metabolic Health)

Biography

Dr Laura Dowsett is a Research Fellow at the BHF Glasgow Cardiovascular Research Centre. Laura first graduated from the University of Manchester with a BSc in Pharmacology and Physiology with Industrial Experience (Drug Metabolism Group, Sanofi Aventis). Following this Laura joined the MRC Clinical Science Centre, Imperial College London where she completed her PhD under the supervision of Dr James Leiper. This research focused on understanding the role of the Dimethylarginine dimethylaminohydrolase (DDAH) enzymes and the cardiovascular risk factor ‘ADMA’ in adipocytes and endothelial cells in models of diet induced obesity. Laura’s first post-doctoral position was based at UCL’s Institute of Ophthalmology investigating endothelial cell signalling and models of angiogenesis in retinal disease and cancer progression.

In 2017 Laura rejoined the Leiper Lab as it moved to the University of Glasgow. Here Laura continued to expand her previous work investigating the interaction between ADMA and the Calcium Sensing receptor. Laura is now developing her own research group, continuing her interest in the Calcium sensing receptor in cardiometabolic disease. Other current research interests include adipose-vascular crosstalk, endothelial cell heterogeneity and models of obesity and diabetes. 

Research interests

Research Theme: Vascular Diseases and Comorbidities

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2015 | 2013 | 2012
Number of items: 9.

2024

Riddell, A. , Flynn, A., Bergugnat, H., Dowsett, L. B. and Miller, A. A. (2024) SDMA as a marker and mediator in cerebrovascular disease. Clinical Science, 138(20), pp. 1305-1323. (doi: 10.1042/CS20241021)

2023

Dowsett, L. , Duluc, L., Higgins, E., Alghamdi, F., Fast, W., Salt, I. P. and Leiper, J. (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular Signalling, 107, 110676. (doi: 10.1016/j.cellsig.2023.110676) (PMID:37028778)

2022

Dritsoula, A., Dowsett, L. , Pilotti, C., O'Connor, M. N., Moss, S. E. and Greenwood, J. (2022) Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway. Scientific Reports, 12, 4867. (doi: 10.1038/s41598-022-08516-2) (PMID:35318338) (PMCID:PMC8938720)

2021

O'Connor, M. N. et al. (2021) LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency. Med, 2(11), 1231-1252.e10. (doi: 10.1016/j.medj.2021.10.002) (PMID:35590198)

2020

Dowsett, L. , Higgins, E., Alanazi, S., Alshuwayer, N. A., Leiper, F. C. and Leiper, J. (2020) ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis. Journal of Clinical Medicine, 9(9), 3026. (doi: 10.3390/jcm9093026) (PMID:32962225) (PMCID:PMC7563400)

2015

Dowsett, L. et al. (2015) Endothelial dimethylarginine dimethylaminohydrolase 1 is an important regulator of angiogenesis but does not regulate vascular reactivity or hemodynamic homeostasis. Circulation, 131(25), pp. 2217-2225. (doi: 10.1161/CIRCULATIONAHA.114.015064) (PMID:25910799)

Lambden, S. et al. (2015) Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(6), pp. 1382-1392. (doi: 10.1161/ATVBAHA.115.305278) (PMID:25857313)

2013

Tsang, H. et al. (2013) Role of asymmetric methylarginine and connexin 43 in the regulation of pulmonary endothelial function. Pulmonary Circulation, 3(3), pp. 675-691. (doi: 10.1086/674440) (PMID:24618552) (PMCID:PMC4070793)

2012

Caplin, B., Wang, Z., Slaviero, A., Tomlinson, J., Dowsett, L. , Delahaye, M., Salama, A., Wheeler, D. C. and Leiper, J. (2012) Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(12), pp. 2892-2900. (doi: 10.1161/ATVBAHA.112.254078) (PMID:23023372)

This list was generated on Fri Dec 20 20:19:24 2024 GMT.
Jump to: Articles
Number of items: 9.

Articles

Riddell, A. , Flynn, A., Bergugnat, H., Dowsett, L. B. and Miller, A. A. (2024) SDMA as a marker and mediator in cerebrovascular disease. Clinical Science, 138(20), pp. 1305-1323. (doi: 10.1042/CS20241021)

Dowsett, L. , Duluc, L., Higgins, E., Alghamdi, F., Fast, W., Salt, I. P. and Leiper, J. (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular Signalling, 107, 110676. (doi: 10.1016/j.cellsig.2023.110676) (PMID:37028778)

Dritsoula, A., Dowsett, L. , Pilotti, C., O'Connor, M. N., Moss, S. E. and Greenwood, J. (2022) Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway. Scientific Reports, 12, 4867. (doi: 10.1038/s41598-022-08516-2) (PMID:35318338) (PMCID:PMC8938720)

O'Connor, M. N. et al. (2021) LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency. Med, 2(11), 1231-1252.e10. (doi: 10.1016/j.medj.2021.10.002) (PMID:35590198)

Dowsett, L. , Higgins, E., Alanazi, S., Alshuwayer, N. A., Leiper, F. C. and Leiper, J. (2020) ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis. Journal of Clinical Medicine, 9(9), 3026. (doi: 10.3390/jcm9093026) (PMID:32962225) (PMCID:PMC7563400)

Dowsett, L. et al. (2015) Endothelial dimethylarginine dimethylaminohydrolase 1 is an important regulator of angiogenesis but does not regulate vascular reactivity or hemodynamic homeostasis. Circulation, 131(25), pp. 2217-2225. (doi: 10.1161/CIRCULATIONAHA.114.015064) (PMID:25910799)

Lambden, S. et al. (2015) Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(6), pp. 1382-1392. (doi: 10.1161/ATVBAHA.115.305278) (PMID:25857313)

Tsang, H. et al. (2013) Role of asymmetric methylarginine and connexin 43 in the regulation of pulmonary endothelial function. Pulmonary Circulation, 3(3), pp. 675-691. (doi: 10.1086/674440) (PMID:24618552) (PMCID:PMC4070793)

Caplin, B., Wang, Z., Slaviero, A., Tomlinson, J., Dowsett, L. , Delahaye, M., Salama, A., Wheeler, D. C. and Leiper, J. (2012) Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(12), pp. 2892-2900. (doi: 10.1161/ATVBAHA.112.254078) (PMID:23023372)

This list was generated on Fri Dec 20 20:19:24 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Reducing with Metformin Adverse Vascular Lesions (REMOVAL) Trial Follow-up - Identifying those at risk of Type 1 Diabetes-associated vascular complications
    The Novo Nordisk UK Research Foundation
    2024 - 2024
     
  • Investigating calcium-sensing receptor mediated sex differences in cardiometabolic disease
    British Heart Foundation
    2024 - 2027
     
  • Asymmetric dimethylarginine signalling via the calcium sensing receptor in the vascular and metabolic complications of type 2 diabetes
    British Heart Foundation
    2021 - 2024
     
  • Using the Endo-Ribotag mouse to identify targtes of ADMA in vascular disease
    Rosetrees Trust
    2019 - 2020
     

Supervision

Teaching

As a Research Fellow the majority of Laura’s teaching comes in the form of mentoring BSc, MSc and PhD students through their laboratory-based projects.

Laura also delivers formal lectures for the MSc Cardiovascular Sciences course.


Dr Laura Dowsett