Dr Laura Denby
- Affiliate (School of Cardiovascular & Metabolic Health)
telephone:
01413308428
email:
Laura.Denby@glasgow.ac.uk
Publications
2020
Nosalski, R. et al. (2020) T cell-derived miRNA-214 mediates perivascular fibrosis in hypertension. Circulation Research, 126, pp. 988-1003. (doi: 10.1161/CIRCRESAHA.119.315428) (PMID:32065054) (PMCID:PMC7147427)
2019
Mark, P. B. and Denby, L. (2019) Renal disease. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 409-417. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_38)
2017
Stevens, K., Denby, L., Patel, R. K., Mark, P. B. , Kettlewell, S., Smith, G. L. , Clancy, M. J., Delles, C. and Jardine, A. G. (2017) Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway. Nephrology Dialysis Transplantation, 32(10), pp. 1617-1627. (doi: 10.1093/ndt/gfw252) (PMID:27448672) (PMCID:PMC5837731)
Lopez-Gordo, E., Doszpoly, A., Duffy, M. R., Coughlan, L., Bradshaw, A. C. , White, K. M., Denby, L., Nicklin, S. A. and Baker, A. H. (2017) Defining a novel role for the coxsackie and adenovirus receptor in human adenovirus serotype 5 transduction in vitro in the presence of mouse serum. Journal of Virology, 91(12), e02487-16. (doi: 10.1128/JVI.02487-16) (PMID:28381574) (PMCID:PMC5446653)
Sodi, R., Eastwood, J., Caslake, M., Packard, C. J. and Denby, L. (2017) Relationship between circulating microRNA-30c with total- and LDL-cholesterol, their circulatory transportation and effect of statins. Clinica Chimica Acta, 466, pp. 13-19. (doi: 10.1016/j.cca.2016.12.031) (PMID:28062296)
2014
Lopez Gordo, E., Denby, L., Nicklin, S. A. and Baker, A. H. (2014) The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery. Expert Opinion on Drug Delivery, 11(11), pp. 1795-1813. (doi: 10.1517/17425247.2014.938637)
Denby, L. et al. (2014) MicroRNA-214 antagonism protects against renal fibrosis. Journal of the American Society of Nephrology, 25(1), pp. 65-80. (doi: 10.1681/ASN.2013010072) (PMID:24158985) (PMCID:PMC3871772)
2013
Ramdas, V., McBride, M. , Denby, L. and Baker, A. H. (2013) Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. American Journal of Pathology, 183(6), pp. 1885-1896. (doi: 10.1016/j.ajpath.2013.08.027)
2012
Miller, A. M., Xu, D., Asquith, D. L., Denby, L., Li, Y., Sattar, N. , Baker, A. H., McInnes, I. B. and Liew, F. Y. (2012) IL-33 reduces the development of atherosclerosis (vol 205, pg 339, 2008). Journal of Experimental Medicine, 209(13), p. 2515. (doi: 10.1084/jem.2007186820913c)
Flores, M., Work, L.M. , Douglas, K., Denby, L., Dominiczak, A.F. , Graham, D. and Nicklin, S.A. (2012) Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor. Hypertension, 59(2), pp. 300-307. (doi: 10.1161/HYPERTENSIONAHA.111.177485)
2011
Denby, L. et al. (2011) miR-21 and miR-214 are consistently modulated during renal injury in rodent models. American Journal of Pathology, 179(2), pp. 661-672. (doi: 10.1016/j.ajpath.2011.04.021)
2010
Greig, J.A., Shirley, R., Graham, D. , Denby, L., Dominiczak, A.F. , Work, L.M. and Baker, A. (2010) Vascular-targeting anti-oxidant therapy in a model of hypertension and stroke. Journal of Cardiovascular Pharmacology, 56(6), pp. 642-650. (doi: 10.1097/FJC.0b013e3181f8f19f)
Alba, R. et al. (2010) Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors. Blood, 14(116), pp. 2656-2664. (doi: 10.1182/blood-2009-12-260026)
Caruso, P. et al. (2010) Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(4), pp. 716-723. (doi: 10.1161/ATVBAHA.109.202028)
2009
Nicol, C. G., Denby, L., Lopez-Franco, O., Masson, R., Halliday, C. A., Nicklin, S. A., Kritz, A., Work, L. M. and Baker, A. H. (2009) Use of in vivo phage display to engineer novel adenoviruses for targeted delivery to the cardiac vasculature. FEBS Letters, 583(12), pp. 2100-2107. (doi: 10.1016/j.febslet.2009.05.037)
Diaconu, I. et al. (2009) Serotype chimeric and fiber-mutated adenovirus Ad5/19p-HIT for targeting renal cancer and untargeting the liver. Human Gene Therapy, 20(6), pp. 611-620. (doi: 10.1089/hum.2008.108)
Lenaerts, L., Mcvey, J., Baker, A., Denby, L., Nicklin, S., Verbeken, E. and Naesens, L. (2009) Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting. Journal of Gene Medicine, 11(2), pp. 119-127. (doi: 10.1002/jgm.1283)
2008
Waddington, S. et al. (2008) Adenovirus serotype 5 hexon mediates liver gene transfer. Cell, 132(3), pp. 397-409. (doi: 10.1016/j.cell.2008.01.016)
Miller, A. M., Xu, D., Asquith, D. L., Denby, L., Li, Y., Sattar, N. , Baker, A. H., McInnes, I. B. and Liew, F. Y. (2008) IL-33 reduces the development of atherosclerosis. Journal of Experimental Medicine, 205(2), pp. 339-346. (doi: 10.1084/jem.20071868) (PMID:18268038) (PMCID:PMC2271006)
Waddington, S. et al. (2008) A critical role for the adenovirus serotype 5 hexon in liver gene transfer. Human Gene Therapy, 19(4), p. 40.
2007
Denby, L., Work, L.M., Von Seggern, D.J., Wu, E., Mcvey, J.H., Nicklin, S.A. and Baker, A.H. (2007) Development of renal-targeted vectors through combined in vivo phage display and capsid engineering of adenoviral fibers from serotype 19p. Molecular Therapy, 15(9), pp. 1647-1654. (doi: 10.1038/sj.mt.6300214)
2006
Parker, A.L. et al. (2006) Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes in vitro and in vivo. Blood, 108(8), pp. 2554-2561. (doi: 10.1182/blood-2006-04-008532)
Work, L.M. et al. (2006) Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses. Molecular Therapy, 13(4), pp. 683-693. (doi: 10.1016/j.ymthe.2005.11.013)
2005
Denby, L., Nicklin, S.A. and Baker, A.H. (2005) Adeno-associated virus (AAV)-7 and-8 poorly transduce vascular endothelial cells and are sensitive to proteasomal degradation. Gene Therapy, 12, pp. 1534-1538. (doi: 10.1038/sj.gt.3302564)
2004
Denby, L., Work, L.M., Graham, D. , Hsu, C., Von Seggern, D.J., Nicklin, S.A. and Baker, A.H. (2004) Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo. Human Gene Therapy, 15(11), pp. 1054-1064.
Work, L.M., Nicol, C.G., Denby, L. and Baker, A.H. (2004) In vivo biopanning: a methodological approach to identifying novel targeting ligands for delivery of biological agents to the vasculature. In: Fennell, J.P. and Baker, A.H. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular medicine (108). Humana Press: Totowa, NJ, USA, pp. 395-413. ISBN 9781588293237 (doi: 10.1385/1-59259-850-1:395)
2003
Dishart, K.L., Work, L.M. , Denby, L. and Baker, A.H. (2003) Gene therapy for cardiovascular disease. Journal of Biomedicine and Biotechnology, 2003(2), pp. 138-148. (doi: 10.1155/S1110724303209086)
Dishart, K.L. et al. (2003) Third-generation lentivirus vectors efficiently transduce and phenotypically modify vascular cells: implications for gene therapy. Journal of Molecular and Cellular Cardiology, 35(7), pp. 739-748. (doi: 10.1016/S0022-2828(03)00136-6)
Articles
Nosalski, R. et al. (2020) T cell-derived miRNA-214 mediates perivascular fibrosis in hypertension. Circulation Research, 126, pp. 988-1003. (doi: 10.1161/CIRCRESAHA.119.315428) (PMID:32065054) (PMCID:PMC7147427)
Stevens, K., Denby, L., Patel, R. K., Mark, P. B. , Kettlewell, S., Smith, G. L. , Clancy, M. J., Delles, C. and Jardine, A. G. (2017) Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway. Nephrology Dialysis Transplantation, 32(10), pp. 1617-1627. (doi: 10.1093/ndt/gfw252) (PMID:27448672) (PMCID:PMC5837731)
Lopez-Gordo, E., Doszpoly, A., Duffy, M. R., Coughlan, L., Bradshaw, A. C. , White, K. M., Denby, L., Nicklin, S. A. and Baker, A. H. (2017) Defining a novel role for the coxsackie and adenovirus receptor in human adenovirus serotype 5 transduction in vitro in the presence of mouse serum. Journal of Virology, 91(12), e02487-16. (doi: 10.1128/JVI.02487-16) (PMID:28381574) (PMCID:PMC5446653)
Sodi, R., Eastwood, J., Caslake, M., Packard, C. J. and Denby, L. (2017) Relationship between circulating microRNA-30c with total- and LDL-cholesterol, their circulatory transportation and effect of statins. Clinica Chimica Acta, 466, pp. 13-19. (doi: 10.1016/j.cca.2016.12.031) (PMID:28062296)
Lopez Gordo, E., Denby, L., Nicklin, S. A. and Baker, A. H. (2014) The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery. Expert Opinion on Drug Delivery, 11(11), pp. 1795-1813. (doi: 10.1517/17425247.2014.938637)
Denby, L. et al. (2014) MicroRNA-214 antagonism protects against renal fibrosis. Journal of the American Society of Nephrology, 25(1), pp. 65-80. (doi: 10.1681/ASN.2013010072) (PMID:24158985) (PMCID:PMC3871772)
Ramdas, V., McBride, M. , Denby, L. and Baker, A. H. (2013) Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. American Journal of Pathology, 183(6), pp. 1885-1896. (doi: 10.1016/j.ajpath.2013.08.027)
Miller, A. M., Xu, D., Asquith, D. L., Denby, L., Li, Y., Sattar, N. , Baker, A. H., McInnes, I. B. and Liew, F. Y. (2012) IL-33 reduces the development of atherosclerosis (vol 205, pg 339, 2008). Journal of Experimental Medicine, 209(13), p. 2515. (doi: 10.1084/jem.2007186820913c)
Flores, M., Work, L.M. , Douglas, K., Denby, L., Dominiczak, A.F. , Graham, D. and Nicklin, S.A. (2012) Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor. Hypertension, 59(2), pp. 300-307. (doi: 10.1161/HYPERTENSIONAHA.111.177485)
Denby, L. et al. (2011) miR-21 and miR-214 are consistently modulated during renal injury in rodent models. American Journal of Pathology, 179(2), pp. 661-672. (doi: 10.1016/j.ajpath.2011.04.021)
Greig, J.A., Shirley, R., Graham, D. , Denby, L., Dominiczak, A.F. , Work, L.M. and Baker, A. (2010) Vascular-targeting anti-oxidant therapy in a model of hypertension and stroke. Journal of Cardiovascular Pharmacology, 56(6), pp. 642-650. (doi: 10.1097/FJC.0b013e3181f8f19f)
Alba, R. et al. (2010) Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors. Blood, 14(116), pp. 2656-2664. (doi: 10.1182/blood-2009-12-260026)
Caruso, P. et al. (2010) Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(4), pp. 716-723. (doi: 10.1161/ATVBAHA.109.202028)
Nicol, C. G., Denby, L., Lopez-Franco, O., Masson, R., Halliday, C. A., Nicklin, S. A., Kritz, A., Work, L. M. and Baker, A. H. (2009) Use of in vivo phage display to engineer novel adenoviruses for targeted delivery to the cardiac vasculature. FEBS Letters, 583(12), pp. 2100-2107. (doi: 10.1016/j.febslet.2009.05.037)
Diaconu, I. et al. (2009) Serotype chimeric and fiber-mutated adenovirus Ad5/19p-HIT for targeting renal cancer and untargeting the liver. Human Gene Therapy, 20(6), pp. 611-620. (doi: 10.1089/hum.2008.108)
Lenaerts, L., Mcvey, J., Baker, A., Denby, L., Nicklin, S., Verbeken, E. and Naesens, L. (2009) Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting. Journal of Gene Medicine, 11(2), pp. 119-127. (doi: 10.1002/jgm.1283)
Waddington, S. et al. (2008) Adenovirus serotype 5 hexon mediates liver gene transfer. Cell, 132(3), pp. 397-409. (doi: 10.1016/j.cell.2008.01.016)
Miller, A. M., Xu, D., Asquith, D. L., Denby, L., Li, Y., Sattar, N. , Baker, A. H., McInnes, I. B. and Liew, F. Y. (2008) IL-33 reduces the development of atherosclerosis. Journal of Experimental Medicine, 205(2), pp. 339-346. (doi: 10.1084/jem.20071868) (PMID:18268038) (PMCID:PMC2271006)
Waddington, S. et al. (2008) A critical role for the adenovirus serotype 5 hexon in liver gene transfer. Human Gene Therapy, 19(4), p. 40.
Denby, L., Work, L.M., Von Seggern, D.J., Wu, E., Mcvey, J.H., Nicklin, S.A. and Baker, A.H. (2007) Development of renal-targeted vectors through combined in vivo phage display and capsid engineering of adenoviral fibers from serotype 19p. Molecular Therapy, 15(9), pp. 1647-1654. (doi: 10.1038/sj.mt.6300214)
Parker, A.L. et al. (2006) Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes in vitro and in vivo. Blood, 108(8), pp. 2554-2561. (doi: 10.1182/blood-2006-04-008532)
Work, L.M. et al. (2006) Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses. Molecular Therapy, 13(4), pp. 683-693. (doi: 10.1016/j.ymthe.2005.11.013)
Denby, L., Nicklin, S.A. and Baker, A.H. (2005) Adeno-associated virus (AAV)-7 and-8 poorly transduce vascular endothelial cells and are sensitive to proteasomal degradation. Gene Therapy, 12, pp. 1534-1538. (doi: 10.1038/sj.gt.3302564)
Denby, L., Work, L.M., Graham, D. , Hsu, C., Von Seggern, D.J., Nicklin, S.A. and Baker, A.H. (2004) Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo. Human Gene Therapy, 15(11), pp. 1054-1064.
Dishart, K.L., Work, L.M. , Denby, L. and Baker, A.H. (2003) Gene therapy for cardiovascular disease. Journal of Biomedicine and Biotechnology, 2003(2), pp. 138-148. (doi: 10.1155/S1110724303209086)
Dishart, K.L. et al. (2003) Third-generation lentivirus vectors efficiently transduce and phenotypically modify vascular cells: implications for gene therapy. Journal of Molecular and Cellular Cardiology, 35(7), pp. 739-748. (doi: 10.1016/S0022-2828(03)00136-6)
Book Sections
Mark, P. B. and Denby, L. (2019) Renal disease. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 409-417. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_38)
Work, L.M., Nicol, C.G., Denby, L. and Baker, A.H. (2004) In vivo biopanning: a methodological approach to identifying novel targeting ligands for delivery of biological agents to the vasculature. In: Fennell, J.P. and Baker, A.H. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular medicine (108). Humana Press: Totowa, NJ, USA, pp. 395-413. ISBN 9781588293237 (doi: 10.1385/1-59259-850-1:395)