Dr Yvonne Dempsie
- Honorary Research Associate (School of Cardiovascular & Metabolic Health)
email:
Yvonne.Dempsie@glasgow.ac.uk
Glasgow Caledonian University, Glasgow, G4 0BA
Publications
2014
White, K. et al. (2014) Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis. Hypertension, 64(1), pp. 185-194. (doi: 10.1161/HYPERTENSIONAHA.113.03037)
2013
Grant, J. S., Morecroft, I., Dempsie, Y., van Rooij, E., MacLean, M. R. and Baker, A. H. (2013) Transient but not genetic loss of miR-451 attenuates the development of pulmonary arterial hypertension. Pulmonary Circulation, 3(4), pp. 840-850. (doi: 10.1086/674751) (PMID:25006399) (PMCID:PMC4070830)
Dempsie, Y. and Maclean, M. R. (2013) The influence of gender on the development of pulmonary arterial hypertension. Experimental Physiology, 98, pp. 1257-1261. (doi: 10.1113/expphysiol.2012.069120)
Dempsie, Y., MacRitchie, N.A., White, K., Morecroft, I., Wright, A.F., Nilsen, M., Loughlin, L., Mair, K.M. and MacLean, M.R. (2013) Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension. Cardiovascular Research, 99(1), pp. 24-34. (doi: 10.1093/cvr/cvt064) (PMID:23519266) (PMCID:PMC3687748)
2012
Caruso, P. et al. (2012) A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples. Circulation Research, 111(3), pp. 290-300. (doi: 10.1161/CIRCRESAHA.112.267591)
2011
Dempsie, Y., Nilsen, M., White, K., Mair, K., Loughlin, L., Ambartsumian, N., Rabinovitch, M. and MacLean, M. (2011) Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females. Respiratory Research, 12(1), p. 159. (doi: 10.1186/1465-9921-12-159)
White, K., Loughlin, L., Maqbool, Z., Nilsen, M., McClure, J. , Dempsie, Y., Baker, A. H. and MacLean, M. R. (2011) Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH. Physiological Genomics, 43(8), pp. 417-437. (doi: 10.1152/physiolgenomics.00249.2010)
White, K., Dempsie, Y., Nilsen, M., Wright, A. F., Loughlin, L. and MacLean, M. R. (2011) The serotonin transporter, gender, and 17β oestradiol in the development of pulmonary arterial hypertension. Cardiovascular Research, 90(2), pp. 373-382. (doi: 10.1093/cvr/cvq408)
2010
Caruso, P. et al. (2010) Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(4), pp. 716-723. (doi: 10.1161/ATVBAHA.109.202028)
MacLean, M. R. and Dempsie, Y. (2010) The serotonin hypothesis of pulmonary hypertension revisited. In: Membrane Receptors, Channels and Transporters in Pulmonary Circulation. Series: Advances in experimental medicine and biology ;; v. 661, 661. Humana Press: New York, pp. 309-322. ISBN 9781607614999 (doi: 10.1007/978-1-60761-500-2_20)
Morecroft, I., Pang, L., Baranowska, M., Nilsen, M., Loughlin, L., Dempsie, Y., Millet, C. and MacLean, M. R. (2010) In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Cardiovascular Research, 85(3), pp. 593-603. (doi: 10.1093/cvr/cvp306) (PMID:19736308)
Morecroft, I., Pang, L., Baranowska, M., Nilsen, M., Loughlin, L., Dempsie, Y., Millet, C. and MacLean, M. R. (2010) In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Cardiovascular Research, 85(3), pp. 593-603. (doi: 10.1093/cvr/cvp306) (PMID:19736308)
Kelland, N.F., Bagnall, A.J., Morecroft, I., Gulliver-Sloan, F.H., Dempsie, Y., Nilsen, M., Yanagisawa, M., MacLean, M.R., Kotelevtsev, Y.V. and Webb, D.J. (2010) Endothelial ET limits vascular remodelling and development of pulmonary hypertension during hypoxia. Journal of Vascular Research, 47(1), pp. 16-22. (doi: 10.1159/000231717) (PMID:19672104)
2009
MacLean, M.R. and Dempsie, Y. (2009) Serotonin and pulmonary hypertension—from bench to bedside? Current Opinion in Pharmacology, 9(3), pp. 281-286. (doi: 10.1016/j.coph.2009.02.005)
2008
Dempsie, Y. and MacLean, M.R. (2008) Role of the serotonin transporter in pulmonary arterial hypertension. Expert Review of Clinical Pharmacology, 1(6), pp. 749-757. (doi: 10.1586/17512433.1.6.749)
Mair, K.M., MacLean, M.R., Morecroft, I., Dempsie, Y. and Palmer, T.M. (2008) Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts. British Journal of Pharmacology, 155(4), pp. 606-616. (doi: 10.1038/bjp.2008.310) (PMID:18695640) (PMCID:PMC2579673)
Dempsie, Y. et al. (2008) Converging Evidence in Support of the Serotonin Hypothesis of Dexfenfluramine-Induced Pulmonary Hypertension With Novel Transgenic Mice. Circulation, 117(22), pp. 2928-2937. (doi: 10.1161/CIRCULATIONAHA.108.767558)
Dempsie, Y. and MacLean, M.R. (2008) Pulmonary hypertension: therapeutic targets within the serotonin system. British Journal of Pharmacology, 155(4), pp. 455-462. (doi: 10.1038/bjp.2008.241)
2007
Morecroft, I., Dempsie, Y., Bader, M., Walther, D.J., Kotnik, K., Loughlin, L., Nilsen, M. and MacLean, M.R. (2007) Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension. Hypertension, 49, pp. 232-236. (doi: 10.1161/01.HYP.0000252210.58849.78)
2006
Deuchar, G.A., Morecroft, I., Dempsie, Y., Herold, N., Nilsen, M., Hicks, M.N. and MacLean, M.R. (2006) The in vivo effects of human urotensin II in the rabbit and rat pulmonary circulation: effects of experimental pulmonary hypertension. European Journal of Pharmacology, 537, pp. 135-142. (doi: 10.1016/j.ejphar.2006.03.025)
2005
Morecroft, I., Loughlin, L., Nilsen, M., Colston, J., Dempsie, Y., Sheward, J., Harmar, A. and MacLean, M.R. (2005) Functional interactions between 5-hydroxytryptamine receptors and the serotonin transporter in pulmonary arteries. Journal of Pharmacology and Experimental Therapeutics, 313, pp. 539-548. (doi: 10.1124/jpet.104.081182)
2004
MacLean, M.R. et al. (2004) Overexpression of the 5-hydroxytryptamine transporter gene - effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension. Circulation, 109, pp. 2150-2155. (doi: 10.1161/01.CIR.0000127375.56172.92)
Articles
White, K. et al. (2014) Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis. Hypertension, 64(1), pp. 185-194. (doi: 10.1161/HYPERTENSIONAHA.113.03037)
Grant, J. S., Morecroft, I., Dempsie, Y., van Rooij, E., MacLean, M. R. and Baker, A. H. (2013) Transient but not genetic loss of miR-451 attenuates the development of pulmonary arterial hypertension. Pulmonary Circulation, 3(4), pp. 840-850. (doi: 10.1086/674751) (PMID:25006399) (PMCID:PMC4070830)
Dempsie, Y. and Maclean, M. R. (2013) The influence of gender on the development of pulmonary arterial hypertension. Experimental Physiology, 98, pp. 1257-1261. (doi: 10.1113/expphysiol.2012.069120)
Dempsie, Y., MacRitchie, N.A., White, K., Morecroft, I., Wright, A.F., Nilsen, M., Loughlin, L., Mair, K.M. and MacLean, M.R. (2013) Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension. Cardiovascular Research, 99(1), pp. 24-34. (doi: 10.1093/cvr/cvt064) (PMID:23519266) (PMCID:PMC3687748)
Caruso, P. et al. (2012) A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples. Circulation Research, 111(3), pp. 290-300. (doi: 10.1161/CIRCRESAHA.112.267591)
Dempsie, Y., Nilsen, M., White, K., Mair, K., Loughlin, L., Ambartsumian, N., Rabinovitch, M. and MacLean, M. (2011) Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females. Respiratory Research, 12(1), p. 159. (doi: 10.1186/1465-9921-12-159)
White, K., Loughlin, L., Maqbool, Z., Nilsen, M., McClure, J. , Dempsie, Y., Baker, A. H. and MacLean, M. R. (2011) Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH. Physiological Genomics, 43(8), pp. 417-437. (doi: 10.1152/physiolgenomics.00249.2010)
White, K., Dempsie, Y., Nilsen, M., Wright, A. F., Loughlin, L. and MacLean, M. R. (2011) The serotonin transporter, gender, and 17β oestradiol in the development of pulmonary arterial hypertension. Cardiovascular Research, 90(2), pp. 373-382. (doi: 10.1093/cvr/cvq408)
Caruso, P. et al. (2010) Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(4), pp. 716-723. (doi: 10.1161/ATVBAHA.109.202028)
Morecroft, I., Pang, L., Baranowska, M., Nilsen, M., Loughlin, L., Dempsie, Y., Millet, C. and MacLean, M. R. (2010) In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Cardiovascular Research, 85(3), pp. 593-603. (doi: 10.1093/cvr/cvp306) (PMID:19736308)
Morecroft, I., Pang, L., Baranowska, M., Nilsen, M., Loughlin, L., Dempsie, Y., Millet, C. and MacLean, M. R. (2010) In vivo effects of a combined 5-HT1B receptor/SERT antagonist in experimental pulmonary hypertension. Cardiovascular Research, 85(3), pp. 593-603. (doi: 10.1093/cvr/cvp306) (PMID:19736308)
Kelland, N.F., Bagnall, A.J., Morecroft, I., Gulliver-Sloan, F.H., Dempsie, Y., Nilsen, M., Yanagisawa, M., MacLean, M.R., Kotelevtsev, Y.V. and Webb, D.J. (2010) Endothelial ET limits vascular remodelling and development of pulmonary hypertension during hypoxia. Journal of Vascular Research, 47(1), pp. 16-22. (doi: 10.1159/000231717) (PMID:19672104)
MacLean, M.R. and Dempsie, Y. (2009) Serotonin and pulmonary hypertension—from bench to bedside? Current Opinion in Pharmacology, 9(3), pp. 281-286. (doi: 10.1016/j.coph.2009.02.005)
Dempsie, Y. and MacLean, M.R. (2008) Role of the serotonin transporter in pulmonary arterial hypertension. Expert Review of Clinical Pharmacology, 1(6), pp. 749-757. (doi: 10.1586/17512433.1.6.749)
Mair, K.M., MacLean, M.R., Morecroft, I., Dempsie, Y. and Palmer, T.M. (2008) Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts. British Journal of Pharmacology, 155(4), pp. 606-616. (doi: 10.1038/bjp.2008.310) (PMID:18695640) (PMCID:PMC2579673)
Dempsie, Y. et al. (2008) Converging Evidence in Support of the Serotonin Hypothesis of Dexfenfluramine-Induced Pulmonary Hypertension With Novel Transgenic Mice. Circulation, 117(22), pp. 2928-2937. (doi: 10.1161/CIRCULATIONAHA.108.767558)
Dempsie, Y. and MacLean, M.R. (2008) Pulmonary hypertension: therapeutic targets within the serotonin system. British Journal of Pharmacology, 155(4), pp. 455-462. (doi: 10.1038/bjp.2008.241)
Morecroft, I., Dempsie, Y., Bader, M., Walther, D.J., Kotnik, K., Loughlin, L., Nilsen, M. and MacLean, M.R. (2007) Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension. Hypertension, 49, pp. 232-236. (doi: 10.1161/01.HYP.0000252210.58849.78)
Deuchar, G.A., Morecroft, I., Dempsie, Y., Herold, N., Nilsen, M., Hicks, M.N. and MacLean, M.R. (2006) The in vivo effects of human urotensin II in the rabbit and rat pulmonary circulation: effects of experimental pulmonary hypertension. European Journal of Pharmacology, 537, pp. 135-142. (doi: 10.1016/j.ejphar.2006.03.025)
Morecroft, I., Loughlin, L., Nilsen, M., Colston, J., Dempsie, Y., Sheward, J., Harmar, A. and MacLean, M.R. (2005) Functional interactions between 5-hydroxytryptamine receptors and the serotonin transporter in pulmonary arteries. Journal of Pharmacology and Experimental Therapeutics, 313, pp. 539-548. (doi: 10.1124/jpet.104.081182)
MacLean, M.R. et al. (2004) Overexpression of the 5-hydroxytryptamine transporter gene - effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension. Circulation, 109, pp. 2150-2155. (doi: 10.1161/01.CIR.0000127375.56172.92)
Book Sections
MacLean, M. R. and Dempsie, Y. (2010) The serotonin hypothesis of pulmonary hypertension revisited. In: Membrane Receptors, Channels and Transporters in Pulmonary Circulation. Series: Advances in experimental medicine and biology ;; v. 661, 661. Humana Press: New York, pp. 309-322. ISBN 9781607614999 (doi: 10.1007/978-1-60761-500-2_20)