Miss Elaine Brown
- Technician (Cardiovascular & Metabolic Health)
Publications
2024
Bai, M. et al. (2024) Targeted degradation of zDHHC-PATs decreases substrate S -palmitoylation. PLoS ONE, 19(3), e0299665. (doi: 10.1371/journal.pone.0299665) (PMID:38512906) (PMCID:PMC10956751)
Ashford, F., Kuo, C.-W. , Dunning, E., Brown, E., Calagan, S., Jayasinghe, I., Henderson, C., Fuller, W. and Wypijewski, K. (2024) Cysteine post-translational modifications regulate protein interactions of caveolin-3. FASEB Journal, 38(5), e23535. (doi: 10.1096/fj.202201497RR) (PMID:38466300)
Howie, J. et al. (2024) Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6. Cell Reports, 43(2), 113679. (doi: 10.1016/j.celrep.2024.113679) (PMID:38236777)
2023
Congreve, S. D., Main, A., Butler, A. S., Gao, X., Brown, E., Du, C., Choisy, S. C., Cheng, H., Hancox, J. C. and Fuller, W. (2023) Palmitoylation regulates the magnitude of HCN4-mediated currents in mammalian cells. Frontiers in Physiology, 14, 1163339. (doi: 10.3389/fphys.2023.1163339) (PMID:37123274) (PMCID:PMC10133559)
2022
Gao, X. et al. (2022) Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7. Cell Calcium, 106, 102639. (doi: 10.1016/j.ceca.2022.102639) (PMID:36027648)
2020
Plain, F., Howie, J., Kennedy, J., Brown, E., Shattock, M. J., Fraser, N. J. and Fuller, W. (2020) Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase. Communications Biology, 3, 411. (doi: 10.1038/s42003-020-01145-3) (PMID:32737405) (PMCID:PMC7395175)
2016
Duncan, S. M., Myburgh, E. , Philipon, C., Brown, E., Meissner, M. , Brewer, J. and Mottram, J. (2016) Conditional gene deletion with DiCre demonstrates an essential role for CRK3 in Leishmania mexicana cell cycle regulation. Molecular Microbiology, 100(6), pp. 931-944. (doi: 10.1111/mmi.13375) (PMID:26991545) (PMCID:PMC4913733)
Grewal, J. S. et al. (2016) PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast. Journal of Biological Chemistry, 291, pp. 9492-9500. (doi: 10.1074/jbc.M116.714972) (PMID:26940875) (PMCID:PMC4850289)
2015
Moss, C. X., Brown, E., Hamilton, A., Van der Veken, P., Augustyns, K. and Mottram, J. (2015) An essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma brucei. PLoS ONE, 10(3), e0123241. (doi: 10.1371/journal.pone.0123241) (PMID:25816352) (PMCID:PMC4376731)
2014
Jones, N. G., Thomas, E. B., Brown, E., Dickens, N. J. , Hammarton, T. C. and Mottram, J. C. (2014) Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen. PLoS Pathogens, 10(1), e1003886. (doi: 10.1371/journal.ppat.1003886)
2011
Munday, J. C. , McLuskey, K., Brown, E., Coombs, G. H. and Mottram, J. C. (2011) Oligopeptidase B deficient mutants of Leishmania major. Molecular and Biochemical Parasitology, 175(1), pp. 49-57. (doi: 10.1016/j.molbiopara.2010.09.003)
Walker, R.G., Thomson, G., Malone, K., Nowicki, M.W., Brown, E., Blake, D.G., Turner, N.J., Walkinshaw, M.D., Grant, K.M. and Mottram, J.C. (2011) High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase. PLoS Neglected Tropical Diseases, 5(4), e1033. (doi: 10.1371/journal.pntd.0001033)
2010
Gomes, F. C., Ali, N. O. M., Brown, E., Walker, R. G., Grant, K. M. and Mottram, J. C. (2010) Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178. Molecular and Biochemical Parasitology, 171(2), pp. 89-96. (doi: 10.1016/j.molbiopara.2010.03.002)
2009
Monnerat, S., Clucas, C. , Brown, E., Mottram, J. C. and Hammarton, T. C. (2009) Searching for novel cell cycle regulators in Trypanosoma brucei with an RNA interference screen. BMC Research Notes, 2(46), (doi: 10.1186/1756-0500-2-46)
Articles
Bai, M. et al. (2024) Targeted degradation of zDHHC-PATs decreases substrate S -palmitoylation. PLoS ONE, 19(3), e0299665. (doi: 10.1371/journal.pone.0299665) (PMID:38512906) (PMCID:PMC10956751)
Ashford, F., Kuo, C.-W. , Dunning, E., Brown, E., Calagan, S., Jayasinghe, I., Henderson, C., Fuller, W. and Wypijewski, K. (2024) Cysteine post-translational modifications regulate protein interactions of caveolin-3. FASEB Journal, 38(5), e23535. (doi: 10.1096/fj.202201497RR) (PMID:38466300)
Howie, J. et al. (2024) Glutathione-dependent depalmitoylation of phospholemman by peroxiredoxin 6. Cell Reports, 43(2), 113679. (doi: 10.1016/j.celrep.2024.113679) (PMID:38236777)
Congreve, S. D., Main, A., Butler, A. S., Gao, X., Brown, E., Du, C., Choisy, S. C., Cheng, H., Hancox, J. C. and Fuller, W. (2023) Palmitoylation regulates the magnitude of HCN4-mediated currents in mammalian cells. Frontiers in Physiology, 14, 1163339. (doi: 10.3389/fphys.2023.1163339) (PMID:37123274) (PMCID:PMC10133559)
Gao, X. et al. (2022) Palmitoylation regulates cellular distribution of and transmembrane Ca flux through TrpM7. Cell Calcium, 106, 102639. (doi: 10.1016/j.ceca.2022.102639) (PMID:36027648)
Plain, F., Howie, J., Kennedy, J., Brown, E., Shattock, M. J., Fraser, N. J. and Fuller, W. (2020) Control of protein palmitoylation by regulating substrate recruitment to a zDHHC-protein acyltransferase. Communications Biology, 3, 411. (doi: 10.1038/s42003-020-01145-3) (PMID:32737405) (PMCID:PMC7395175)
Duncan, S. M., Myburgh, E. , Philipon, C., Brown, E., Meissner, M. , Brewer, J. and Mottram, J. (2016) Conditional gene deletion with DiCre demonstrates an essential role for CRK3 in Leishmania mexicana cell cycle regulation. Molecular Microbiology, 100(6), pp. 931-944. (doi: 10.1111/mmi.13375) (PMID:26991545) (PMCID:PMC4913733)
Grewal, J. S. et al. (2016) PNT1 is a C11 cysteine peptidase essential for replication of the trypanosome kinetoplast. Journal of Biological Chemistry, 291, pp. 9492-9500. (doi: 10.1074/jbc.M116.714972) (PMID:26940875) (PMCID:PMC4850289)
Moss, C. X., Brown, E., Hamilton, A., Van der Veken, P., Augustyns, K. and Mottram, J. (2015) An essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma brucei. PLoS ONE, 10(3), e0123241. (doi: 10.1371/journal.pone.0123241) (PMID:25816352) (PMCID:PMC4376731)
Jones, N. G., Thomas, E. B., Brown, E., Dickens, N. J. , Hammarton, T. C. and Mottram, J. C. (2014) Regulators of Trypanosoma brucei cell cycle progression and differentiation identified using a kinome-wide RNAi screen. PLoS Pathogens, 10(1), e1003886. (doi: 10.1371/journal.ppat.1003886)
Munday, J. C. , McLuskey, K., Brown, E., Coombs, G. H. and Mottram, J. C. (2011) Oligopeptidase B deficient mutants of Leishmania major. Molecular and Biochemical Parasitology, 175(1), pp. 49-57. (doi: 10.1016/j.molbiopara.2010.09.003)
Walker, R.G., Thomson, G., Malone, K., Nowicki, M.W., Brown, E., Blake, D.G., Turner, N.J., Walkinshaw, M.D., Grant, K.M. and Mottram, J.C. (2011) High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase. PLoS Neglected Tropical Diseases, 5(4), e1033. (doi: 10.1371/journal.pntd.0001033)
Gomes, F. C., Ali, N. O. M., Brown, E., Walker, R. G., Grant, K. M. and Mottram, J. C. (2010) Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178. Molecular and Biochemical Parasitology, 171(2), pp. 89-96. (doi: 10.1016/j.molbiopara.2010.03.002)
Monnerat, S., Clucas, C. , Brown, E., Mottram, J. C. and Hammarton, T. C. (2009) Searching for novel cell cycle regulators in Trypanosoma brucei with an RNA interference screen. BMC Research Notes, 2(46), (doi: 10.1186/1756-0500-2-46)
Research datasets
2024
Ashford, F., Kuo, C.-W., Dunning, E., Brown, E., Calaghan, S., Jayasinghe, I., Henderson, C., Fuller, W. and Wypijewski, K. (2024) Cysteine post-translational modifications regulate protein interactions of caveolin-3. [Data Collection]