2021

Bates, E. A. et al. (2021) In vitro and in vivo evaluation of human adenovirus type 49 as a vector for therapeutic applications. Viruses, 13(8), 1483. (doi: 10.3390/v13081483)

2019

Doszpoly, A., de la Cuesta, F., Lopez-Gordo, E., Bénézech, C., Nicklin, S. A. and Baker, A. H. (2019) Human adenovirus serotype 5 is sensitive to IgM-independent neutralization in vitro and in vivo. Viruses, 11(7), 616. (doi: 10.3390/v11070616) (PMID:31284434) (PMCID:PMC6669743)

Pinel, K., Diver, L. A., White, K., McDonald, R. A. and Baker, A. H. (2019) Substantial dysregulation of miRNA passenger strands underlies the vascular response to injury. Cells, 8(2), 83. (doi: 10.3390/cells8020083) (PMID:30678104) (PMCID:PMC6406808)

Low, E. L., Baker, A. H. and Bradshaw, A. C. (2019) TGFβ, smooth muscle cells and coronary artery disease: a review. Cellular Signalling, 53, pp. 90-101. (doi: 10.1016/j.cellsig.2018.09.004) (PMID:30227237) (PMCID:PMC6293316)

Ballantyne, M. D., Rayner, K. J., Stewart, D. J., Baker, A. H. and Schlosser, K. (2019) MicroRNA and LncRNA in the vascular system. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 149-158. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_14)

2018

Guzik, T. J. et al. (2018) What matters in Cardiovascular Research? Scientific discovery driving clinical delivery. Cardiovascular Research, 114(12), pp. 1565-1568. (doi: 10.1093/cvr/cvy214)

MacAskill, M. G. et al. (2018) Robust revascularization in models of limb ischemia using a clinically translatable human stem cell-derived endothelial cell product. Molecular Therapy, 26(7), pp. 1669-1684. (doi: 10.1016/j.ymthe.2018.03.017) (PMID:29703701) (PMCID:PMC6035339)

English, W. R., Ireland-Zecchini, H., Baker, A. H., Littlewood, T. D., Bennett, M. R. and Murphy, G. (2018) Tissue Inhibitor of Metalloproteinase–3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells. PLoS ONE, 13(4), e0195116. (doi: 10.1371/journal.pone.0195116) (PMID:29617412) (PMCID:PMC5884528)

Duffy, M. R. et al. (2018) Generation and characterization of a novel candidate gene therapy and vaccination vector based on human species D adenovirus type 56. Journal of General Virology, 99(1), pp. 135-147. (doi: 10.1099/jgv.0.000978) (PMID:29154744)

2017

Lopez-Gordo, E., Doszpoly, A., Duffy, M. R., Coughlan, L., Bradshaw, A. C. , White, K. M., Denby, L., Nicklin, S. A. and Baker, A. H. (2017) Defining a novel role for the coxsackie and adenovirus receptor in human adenovirus serotype 5 transduction in vitro in the presence of mouse serum. Journal of Virology, 91(12), e02487-16. (doi: 10.1128/JVI.02487-16) (PMID:28381574) (PMCID:PMC5446653)

Deng, L., Baker, A. H. and Bradshaw, A. C. (2017) MicroRNA delivery strategies to the lung in a model of pulmonary hypertension. In: Ishikawa, K. (ed.) Cardiac Gene Therapy: Methods and Protocols. Series: Methods in molecular biology (1521). Humana Press: New York, NY, pp. 325-338. ISBN 9781493965861 (doi: 10.1007/978-1-4939-6588-5_23)

MacAskill, M. G., Tavares, A. S., Wu, J., Lucatelli, C., Mountford, J. C., Baker, A. H., Newby, D. and Hadoke, P. W.F. (2017) PET cell tracking using (18)F-FLT is not limited by local reuptake of free radiotracer. Scientific Reports, 7, 44233. (doi: 10.1038/srep44233) (PMID:28287126) (PMCID:PMC5347009)

2016

Finan, K. M., Hodge, G., Reynolds, A. M., Hodge, S., Holmes, M. D., Baker, A. H. and Reynolds, P. N. (2016) Corrigendum to "In vitro susceptibility to the pro-apoptotic effects of TIMP-3 gene delivery translates to greater in vivo efficacy versus gene delivery for TIMPs-1 or -2" [Lung Cancer 53 (3) (September 2006) 273-284]. Lung Cancer, 101, p. 149. (doi: 10.1016/j.lungcan.2016.06.002) (PMID:27312600)

Deng, L., Bradshaw, A. C. and Baker, A. H. (2016) Role of noncoding RNA in vascular remodelling. Current Opinion in Lipidology, 27(5), pp. 439-448. (doi: 10.1097/MOL.0000000000000336) (PMID:27472407)

Lavery, C. A., Kurowska-Stolarska, M. , Holmes, W. , Donnelly, I., Caslake, M., Collier, A., Baker, A. H. and Miller, A. M. (2016) miR-34a-/- mice are susceptible to diet-induced obesity. Obesity, 24(8), pp. 1741-1751. (doi: 10.1002/oby.21561) (PMID:27377585) (PMCID:PMC4979678)

Duffy, M.R., Doszpoly, A., Turner, G., Nicklin, S.A. and Baker, A.H. (2016) The relevance of coagulation factor X protection of adenoviruses in human sera. Gene Therapy, 23(7), pp. 592-596. (doi: 10.1038/gt.2016.32) (PMID:27014840) (PMCID:PMC4940928)

Ballantyne, M. D. et al. (2016) Smooth muscle enriched long noncoding RNA (SMILR) regulates cell proliferation. Circulation, 133(21), pp. 2050-2065. (doi: 10.1161/circulationaha.115.021019) (PMID:27052414) (PMCID:PMC4872641)

Ballantyne, M.D., McDonald, R.A. and Baker, A.H. (2016) lncRNA/MicroRNA interactions in the vasculature. Clinical Pharmacology and Therapeutics, 99(5), pp. 494-501. (doi: 10.1002/cpt.355) (PMID:26910520)

Stevens, H. C., Deng, L., Grant, J. S., Pinel, K., Thomas, M., Morrell, N. W., MacLean, M. R. and Baker, A. (2016) Regulation and function of miR-214 in pulmonary arterial hypertension. Pulmonary Circulation, 6(1), pp. 109-117. (doi: 10.1086/685079) (PMID:27162619) (PMCID:PMC4860547)

Alonso-Padilla, J., Papp, T., Kaján, G. L., Benkő, M., Havenga, M., Lemckert, A., Harrach, B. and Baker, A. H. (2016) Development of novel adenoviral vectors to overcome challenges observed with HAdV-5 based constructs. Molecular Therapy, (doi: 10.1038/mt.2015.194) (PMID:26478249) (PMCID:PMC4754553)

Boulberdaa, M. et al. (2016) A role for the long non-coding RNA SENCR in commitment and function of endothelial cells. Molecular Therapy, 24(5), pp. 978-990. (doi: 10.1038/mt.2016.41) (PMID:26898221) (PMCID:PMC4876031)

2015

Brittan, M., Hunter, A., Boulberdaa, M., Fujisawa, T., Skinner, E. M., Shah, A. S., Baker, A.H. and Mills, N. L. (2015) Impaired vascular function and repair in patients with premature coronary artery disease. European Journal of Preventive Cardiology, 22(12), pp. 1557-1566. (doi: 10.1177/2047487315600169) (PMID:26276790)

Deng, L. et al. (2015) MicroRNA-143 activation regulates smooth muscle and endothelial cell crosstalk in pulmonary arterial hypertension. Circulation Research, 117(10), pp. 870-883. (doi: 10.1161/CIRCRESAHA.115.306806) (PMID:26311719) (PMCID:PMC4620852)

McDonald, R. A., Pinel, K. and Baker, A. H. (2015) Micro(RNA) management of smooth muscle cell phenotype and response to vascular injury. Cardiovascular Research, 107(4), pp. 403-406. (doi: 10.1093/cvr/cvv199) (PMID:26224571)

Schneider, M. D., Baker, A. H. and Riley, P. (2015) Hopx and the cardiomyocyte parentage. Molecular Therapy, 23(9), pp. 1420-1422. (doi: 10.1038/mt.2015.140) (PMID:26321185)

Wallace, E. , Morrell, N. W., Yang, X. D., Long, L., Stevens, H., Nilsen, M., Loughlin, L., Mair, K. M., Baker, A. H. and MacLean, M. R. (2015) A sex-specific microRNA-96/5HT1B Axis influences development of pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine, 191(12), pp. 1432-1442. (doi: 10.1164/rccm.201412-2148OC) (PMID:25871906) (PMCID:PMC4476563)

McDonald, R. A. et al. (2015) Reducing in-stent restenosis therapeutic manipulation of miRNA in vascular remodeling and inflammation. Journal of the American College of Cardiology, 65(21), pp. 2314-2327. (doi: 10.1016/j.jacc.2015.03.549) (PMID:26022821) (PMCID:PMC4444526)

Dakin, R. S., Parker, A. L., Delles, C. , Nicklin, S. A. and Baker, A. H. (2015) Efficient transduction of primary vascular cells by the rare adenovirus serotype 49 vector. Human Gene Therapy, 26(5), pp. 312-319. (doi: 10.1089/hum.2015.019) (PMID:25760682) (PMCID:PMC4442572)

Nicklin, S. A. , Griesenbach, U. and Baker, A. H. (2015) Special focus issue on the annual meeting of the british society for gene and cell therapy. Human Gene Therapy, 26(5), pp. 247-248. (doi: 10.1089/hum.2015.2500) (PMID:25989311)

Duffy, M., Ma, J., Deng, L., Dakin, R. S., Uil, T., Custers, J., Kelly, S. M. , McVey, J. H., Nicklin, S. A. and Baker, A. H. (2015) Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo. PLoS Pathogens, 11(2), e1004673. (doi: 10.1371/journal.ppat.1004673) (PMID:25658827) (PMCID:PMC4450073)

2014

Lopez Gordo, E., Denby, L., Nicklin, S. A. and Baker, A. H. (2014) The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery. Expert Opinion on Drug Delivery, 11(11), pp. 1795-1813. (doi: 10.1517/17425247.2014.938637)

White, K. et al. (2014) Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis. Hypertension, 64(1), pp. 185-194. (doi: 10.1161/HYPERTENSIONAHA.113.03037)

Coughlan, L., Uusi-Kerttula, H., Ma, J., Degg, B. P., Parker, A. L. and Baker, A. H. (2014) Retargeting adenovirus serotype 48 fiber knob domain by peptide incorporation. Human Gene Therapy, 25(4), pp. 385-394. (doi: 10.1089/hum.2014.016) (PMID:24617540)

Baker, A. H. (2014) Adenovirus-based vectors: maximizing opportunities and optimizing a rich diversity of vectors for gene-based therapy. Human Gene Therapy, 25(4), pp. 255-256. (doi: 10.1089/hum.2014.2508)

Denby, L. et al. (2014) MicroRNA-214 antagonism protects against renal fibrosis. Journal of the American Society of Nephrology, 25(1), pp. 65-80. (doi: 10.1681/ASN.2013010072) (PMID:24158985) (PMCID:PMC3871772)

2013

Grant, J. S., Morecroft, I., Dempsie, Y., van Rooij, E., MacLean, M. R. and Baker, A. H. (2013) Transient but not genetic loss of miR-451 attenuates the development of pulmonary arterial hypertension. Pulmonary Circulation, 3(4), pp. 840-850. (doi: 10.1086/674751) (PMID:25006399) (PMCID:PMC4070830)

Grant, J. S., White, K., MacLean, M. R. and Baker, A. H. (2013) MicroRNAs in pulmonary arterial remodeling. Cellular and Molecular Life Sciences, 70(23), pp. 4479-4494. (doi: 10.1007/s00018-013-1382-5)

Ramdas, V., McBride, M. , Denby, L. and Baker, A. H. (2013) Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. American Journal of Pathology, 183(6), pp. 1885-1896. (doi: 10.1016/j.ajpath.2013.08.027)

Scott, E., Loya, K., Mountford, J., Milligan, G. and Baker, A. H. (2013) MicroRNA regulation of endothelial homeostasis and commitment—implications for vascular regeneration strategies using stem cell therapies. Free Radical Biology and Medicine, 64, pp. 52-60. (doi: 10.1016/j.freeradbiomed.2013.04.037)

Duffy, M. R., Parker, A. L., Kalkman, E. R., White, K., Kovalskyy, D., Kelly, S. M. and Baker, A. H. (2013) Identification of novel small molecule inhibitors of adenovirus gene transfer using a high throughput screening approach. Journal of Controlled Release, 170(1), pp. 132-140. (doi: 10.1016/j.jconrel.2013.05.007)

McDonald, R. A. et al. (2013) miRNA-21 is dysregulated in response to vein grafting in multiple models and genetic ablation in mice attenuates neointima formation. European Heart Journal, 34(22), pp. 1636-1643. (doi: 10.1093/eurheartj/eht105)

Baker, A.H., Nicklin, S.A. and Shayakhmetov, D.M. (2013) FX and host defense evasion tactics by adenovirus. Molecular Therapy, 21(6), pp. 1109-1111. (doi: 10.1038/mt.2013.100)

McKimmie, C.S. et al. (2013) An analysis of the function and expression of D6 on lymphatic endothelial cells. Blood, 121(18), pp. 3768-3777. (doi: 10.1182/blood-2012-04-425314)

Baker, A. H. and Delles, C. (2013) Is microRNA-376c a biomarker or mediator of preeclampsia? Hypertension, 61(4), pp. 767-769. (doi: 10.1161/HYPERTENSIONAHA.111.00087)

Bradshaw, A. C. and Baker, A. H. (2013) Gene therapy for cardiovascular disease: perspectives and potential. Vascular Pharmacology, 58(3), pp. 174-181. (doi: 10.1016/j.vph.2012.10.008)

Howard, L., MacKenzie, R. M., Pchelintsev, N. A., McBryan, T., McClure, J. D. , McBride, M. W. , Kane, N. M., Adams, P. D., Milligan, G. and Baker, A. H. (2013) Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment. Stem Cell Research and Therapy, 4(2), Art. 36. (doi: 10.1186/scrt192)

Parker, A.L., White, K.M., Lavery, C.A., Custers, J., Waddington, S.N. and Baker, A.H. (2013) Pseudotyping the adenovirus serotype 5 capsid with both the fibre and penton of serotype 35 enhances vascular smooth muscle cell transduction. Gene Therapy, 20(12), pp. 1158-1164. (doi: 10.1038/gt.2013.44)

Parker, A. L., Bradshaw, A. C. , Alba, R., Nicklin, S. A. and Baker, A. H. (2013) Capsid modification strategies for detargeting adenoviral vectors. In: Chillon, M. and Bosch, A. (eds.) Adenovirus: Methods and Protocols [3rd.]. Series: Methods in molecular biology (1089). Humana Press, pp. 45-59. ISBN 9781627036788 (doi: 10.1007/978-1-62703-679-5_3)

Son, D.J. et al. (2013) The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. Nature Communications, 4, (doi: 10.1038/ncomms4000)

White, K. M., Alba, R., Parker, A. L., Wright, A. F., Bradshaw, A. C. , Delles, C. , McDonald, R. A. and Baker, A. H. (2013) Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile. Journal of Cardiothoracic Surgery, 8(183), (doi: 10.1186/1749-8090-8-183)

2012

Bradshaw, A. C. , Coughlan, L., Miller, A. M.., Nicklin, S. A. , Baker, A. H., Alba, R. and van Rooijen, N. (2012) Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses. Journal of Controlled Release, 164(3), pp. 394-402. (doi: 10.1016/j.jconrel.2012.05.025)

Miller, A. M., Xu, D., Asquith, D. L., Denby, L., Li, Y., Sattar, N. , Baker, A. H., McInnes, I. B. and Liew, F. Y. (2012) IL-33 reduces the development of atherosclerosis (vol 205, pg 339, 2008). Journal of Experimental Medicine, 209(13), p. 2515. (doi: 10.1084/jem.2007186820913c)

Coughlan, L. et al. (2012) Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery. Molecular Therapy, 20(12), pp. 2268-2281. (doi: 10.1038/mt.2012.162) (PMID:22929662) (PMCID:PMC3514487)

Chick, H.E. et al. (2012) Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk. Human Gene Therapy, 23(12), pp. 1247-1257. (doi: 10.1089/hum.2012.042)

Kaupisch, A., Kennedy, L., Stelmanis, V., Tye, B., Kane, N.M., Mountford, J.C., Courtney, A. and Baker, A.H. (2012) Derivation of vascular endothelial cells from human embryonic stem cells under GMP-compliant conditions: towards clinical studies in ischaemic disease. Journal of Cardiovascular Translational Research, 5(5), pp. 605-617. (doi: 10.1007/s12265-012-9379-2)

Robinson, H. C. and Baker, A. H. (2012) How do microRNAs affect vascular smooth muscle cell biology? Current Opinion in Lipidology, 23(5), pp. 405-411. (doi: 10.1097/MOL.0b013e32835719a1)

Robertson, K.E., McDonald, R.A., Oldroyd, K.G., Nicklin, S.A. and Baker, A.H. (2012) Prevention of coronary in-stent restenosis and vein graft failure: Does vascular gene therapy have a role? Pharmacology and Therapeutics, 136(1), pp. 23-34. (doi: 10.1016/j.pharmthera.2012.07.002)

Coughlan, L., Vallath, S., Gros, A., Giménez-Alejandre, M., Van Rooijen, N., Thomas, G.J., Baker, A.H., Cascalló, M., Alemany, R. and Hart, I.R. (2012) Combined fiber modifications both to target αvβ6 and detarget the coxsackievirus–adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5. Human Gene Therapy, 23(9), pp. 960-979. (doi: 10.1089/hum.2011.218)

Caruso, P. et al. (2012) A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples. Circulation Research, 111(3), pp. 290-300. (doi: 10.1161/CIRCRESAHA.112.267591)

Baker, A.H. (2012) Spotlight: Andrew Baker, PhD, FAHA, FESC, FRSE: "A strategy of short-term genetic engineering prevented long-term pathological processes in the vein graft". Circulation, 125(21), F121-F123. (doi: 10.1161/CIR.0b013e31825e771f)

Alba, R., Baker, A. H. and Nicklin, S. (2012) Vector systems for prenatal gene therapy: principles of adenovirus design and production. In: Coutelle, C. and Waddington, S. N. (eds.) Prenatal Gene Therapy: Concepts, Methods, and Protocols. Series: Methods and protocols (891). Humana Press: Totowa, NJ, pp. 55-84. ISBN 9781617798726 (doi: 10.1007/978-1-61779-873-3_4)

Kane, N. M. et al. (2012) Role of MicroRNAs 99b, 181a, and 181b in the differentiation of human embryonic stem cells to vascular endothelial cells. Stem Cells, 30(4), pp. 643-654. (doi: 10.1002/stem.1026)

White, K., Kane, N. M., Milligan, G. and Baker, A. H. (2012) The role of miRNA in stem cell pluripotency and commitment to the vascular endothelial lineage. Microcirculation, 19(3), pp. 196-207. (doi: 10.1111/j.1549-8719.2012.00161.x)

McDonald, R. A., Hata, A., MacLean, M. R., Morrell, N. W. and Baker, A. H. (2012) MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling. Cardiovascular Research, 93(4), pp. 594-604. (doi: 10.1093/cvr/cvr299)

Duffy, M. R., Parker, A. L., Bradshaw, A. C. and Baker, A. H. (2012) Manipulation of adenovirus interactions with host factors for gene therapy applications. Nanomedicine, 7(2), pp. 271-288. (doi: 10.2217/nnm.11.186)

Alba, R., Bradshaw, A.C. , Mestre-Francés, N., Verdier, J.-M., Henaff, D. and Baker, A.H. (2012) Coagulation factor X mediates adenovirus type 5 liver gene transfer in non-human primates (Microcebus murinus). Gene Therapy, 19(1), pp. 109-113. (doi: 10.1038/gt.2011.87)

Coughlan, L., Vallath, S., Gros, A., Giménez-Alejandre, M., Van Rooijen, N., Thomas, G.J., Baker, A.H., Cascalló, M., Alemany, R. and Hart, I.R. (2012) Combined fiber modifications both to target αvβ6 and detarget the coxsackievirus–adenovirus receptor improve virus toxicity profilesIn vivobut fail to improve antitumoral efficacy relative to adenovirus serotype 5. Human Gene Therapy, 23(9), pp. 960-979. (doi: 10.1089/hum.2011.218) (PMID:22708837)

Duffy, M.R., Kalkman, E. and Baker, A.H. (2012) Identification of a novel small molecule inhibitor of FX-mediated Ad5 gene transfer for gene therapy applications. Molecular Therapy, 20(S1), S117-S117. (doi: 10.1038/mt.2012.86)

Flores, M., Graham, D. , Dominiczak, A.F. , Milligan, G. , Baker, A.H. and Nicklin, S.A. (2012) Angiotensin-(1-9) antagonises Angiotensin II-induced cardiac remodeling via the angiotensin type 2 receptor. Proceedings of the Physiological Society, 27, C1.

Flores, M., Graham, D. , Dominiczak, A. F. , Milligan, G. , Baker, A. H. and Nicklin, S. A. (2012) Abstract 231: angiotensin-(1-9) antagonises cardiac remodelling in a mouse model of Angiotensin Ii-induced hypertension. Hypertension, 60, A231.

Morecroft, I., White, K., Caruso, P., Nilsen, M., Loughlin, L., Alba, R., Reynolds, P.N., Danilov, S.M., Baker, A.H. and MacLean, M.R. (2012) Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension. Molecular Therapy, 20(8), pp. 1516-1528. (doi: 10.1038/mt.2012.70)

Rahim, A.A. et al. (2012) In utero administration of Ad5 and AAV pseudotypes to the fetal brain leads to efficient, widespread and long-term gene expression. Gene Therapy, 19(9), pp. 936-946. (doi: 10.1038/gt.2011.157)

2011

Ialenti, A. et al. (2011) Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(11), pp. 2448-2454. (doi: 10.1161/ATVBAHA.111.230078) (PMID:21852559)

Howard, L., Kane, N., Milligan, G. and Baker, A. H. (2011) MicroRNAs regulating cell pluripotency and vascular differentiation. Vascular Pharmacology, 55(4), pp. 69-78. (doi: 10.1016/j.vph.2011.08.002)

Duffy, M.R., Bradshaw, A.C. , Parker, A.L., McVey, J.H. and Baker, A.H. (2011) A cluster of basic amino acids in the factor X serine protease mediate surface attachment of adenovirus/FX complexes. Journal of Virology, 85(20), pp. 10914-10919. (doi: 10.1128/JVI.05382-11)

White, K., Loughlin, L., Maqbool, Z., Nilsen, M., McClure, J. , Dempsie, Y., Baker, A. H. and MacLean, M. R. (2011) Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH. Physiological Genomics, 43(8), pp. 417-437. (doi: 10.1152/physiolgenomics.00249.2010)

Caporali, A. et al. (2011) Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation, 123(3), pp. 282-291. (doi: 10.1161/CIRCULATIONAHA.110.952325)

Kane, N. M., Xiao, Q., Baker, A. H., Luo, Z., Xu, Q. and Emanueli, C. (2011) Pluripotent stem cell differentiation into vascular cells: a novel technology with promises for vascular re(generation). Pharmacology and Therapeutics, 129(1), pp. 29-49. (doi: 10.1016/j.pharmthera.2010.10.004)

Baker, A.H. (2011) MicroRNA 21 "Shapes" Vascular Smooth Muscle Behavior Through Regulating Tropomyosin 1. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(9), pp. 1941-1942. (doi: 10.1161/ATVBAHA.111.231985)

Denby, L. et al. (2011) miR-21 and miR-214 are consistently modulated during renal injury in rodent models. American Journal of Pathology, 179(2), pp. 661-672. (doi: 10.1016/j.ajpath.2011.04.021)

George, S. J., Wan, S., Hu, J., McDonald, R.A., Johnson, J. L. and Baker, A.H. (2011) Sustained reduction of vein graft neointima formation by ex vivo TIMP-3 gene therapy. Circulation, 124(11_sup), S135-S142. (doi: 10.1161/CIRCULATIONAHA.110.012732)

2010

Burton, P. et al. (2010) Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells. Biochemical Journal, 432(3), pp. 575-584. (doi: 10.1042/BJ20100726)

Kane, N. M. et al. (2010) Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors. Molecular Therapy, 18(12), pp. 2139-2145. (doi: 10.1038/mt.2010.231)

Greig, J.A., Shirley, R., Graham, D. , Denby, L., Dominiczak, A.F. , Work, L.M. and Baker, A. (2010) Vascular-targeting anti-oxidant therapy in a model of hypertension and stroke. Journal of Cardiovascular Pharmacology, 56(6), pp. 642-650. (doi: 10.1097/FJC.0b013e3181f8f19f)

Othman, M. et al. (2010) Functional characterization of a 13-bp deletion (c.-1522_-1510del13) in the promoter of the von Willebrand factor gene in type 1 von Willebrand disease. Blood, 116(18), pp. 3645-3652. (doi: 10.1182/blood-2009-12-261131)

Alba, R. et al. (2010) Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors. Blood, 14(116), pp. 2656-2664. (doi: 10.1182/blood-2009-12-260026)

Burton, P. et al. (2010) Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells. Biochemical Society Transactions, 38(4), pp. 1058-1061. (doi: 10.1042/BST0381058)

Kane, N. M., Meloni, M., Spencer, H. L., Craig, M. A., Strehl, R., Milligan, G., Houslay, M. D., Mountford, J. C., Emanueli, C. and Baker, A. H. (2010) Derivation of endothelial cells from human embryonic stem cells by directed differentiation: analysis of microRNA and angiogenesis in vitro and in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(7), pp. 1389-1397. (doi: 10.1161/ATVBAHA.110.204800)

Craig, M. A., McBride, M. W. , Smith, G., George, S. and Baker, A. (2010) Dysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat. Journal of Molecular and Cellular Cardiology, 48(6), pp. 1121-1128. (doi: 10.1016/j.yjmcc.2010.01.017)

Caruso, P. et al. (2010) Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(4), pp. 716-723. (doi: 10.1161/ATVBAHA.109.202028)

Shin, S.Y., Kim, J.H., Baker, A.H., Lim, Y. and Lee, Y.H. (2010) Transcription factor Egr-1 is essential for maximal matrix metalloproteinase-9 transcription by tumor necrosis factor α. Molecular Cancer Research, 8(4), pp. 507-519. (doi: 10.1158/1541-7786.MCR-09-0454) (PMID:20332214)

Balestrieri, M. L. et al. (2010) Therapeutic angiogenesis in diabetic apolipoprotein E-deficient mice using bone marrow cells, functional hemangioblasts and metabolic intervention. Atherosclerosis, 209(2), pp. 403-414. (doi: 10.1016/j.atherosclerosis.2009.10.022)

Bradshaw, A.C. , Parker, A.L., Duffy, M.R., Coughlan, L., van Rooijen, N., Kahari, V.M., Nicklin, S.A. and Baker, A.H. (2010) Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X. PLoS Pathogens, 6(10), e1001142. (doi: 10.1371/journal.ppat.1001142)

Coughlan, L., Alba, R., Parker, A.L., Bradshaw, A.C. , Mcneish, I.A. , Nicklin, S. and Baker, A. (2010) Tropism-modification strategies for targeted gene delivery using adenoviral vectors. Viruses, 2(10), pp. 2290-2355. (doi: 10.3390/v2102290) (PMID:21994621) (PMCID:PMC3185574)

Kallio, J.P., Hopkins-Donaldson, S., Baker, A.H. and Kähäri, V.M. (2010) TIMP-3 promotes apoptosis in nonadherent small cell lung carcinoma cells lacking functional death receptor pathway. International Journal of Cancer, 128(4), pp. 991-996. (doi: 10.1002/ijc.25404)

Nicklin, S. A. and Baker, A. H. (2010) Adenoviral vectors. In: Herzog, R. W. and Zolotukhin, S. (eds.) A Guide to Human Gene Therapy. World Scientific Publishing, pp. 21-36. ISBN 9789814280907 (doi: 10.1142/9789814280914_0002)

Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6(10), e1001177. (doi: 10.1371/journal.pgen.1001177)

2009

Masson, R., Nicklin, S. A. and Baker, A. H. (2009) Gene delivery to cardiovascular tissue. In: Abraham, D., Handler, C., Dashwood, M. and Coghlan, G. (eds.) Advances in Vascular Medicine. Springer London, pp. 25-54. ISBN 9781848826366 (doi: 10.1007/978-1-84882-637-3_2)

Alba, R. et al. (2009) Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer. Blood, 114(5), pp. 965-971. (doi: 10.1182/blood-2009-03-208835)

Terashima, T., Oka, K., Kritz, A. B., Kojima, H., Baker, A. H. and Chan, L. (2009) DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice. Journal of Clinical Investigation, 119(7), pp. 2100-2112. (doi: 10.1172/JCI39038)

Nicol, C. G., Denby, L., Lopez-Franco, O., Masson, R., Halliday, C. A., Nicklin, S. A., Kritz, A., Work, L. M. and Baker, A. H. (2009) Use of in vivo phage display to engineer novel adenoviruses for targeted delivery to the cardiac vasculature. FEBS Letters, 583(12), pp. 2100-2107. (doi: 10.1016/j.febslet.2009.05.037)

Diaconu, I. et al. (2009) Serotype chimeric and fiber-mutated adenovirus Ad5/19p-HIT for targeting renal cancer and untargeting the liver. Human Gene Therapy, 20(6), pp. 611-620. (doi: 10.1089/hum.2008.108)

Liu, Y., Wang, H.J., Yumul, R., Gao, W.T., Gambotto, A., Morita, T., Baker, A.H., Shayakhmetov, D. and Lieber, A. (2009) Transduction of liver metastases after intravenous injection of Ad5/35 or Ad35 vectors with and without factor X-binding protein pretreatment. Human Gene Therapy, 20(6), pp. 621-629. (doi: 10.1089/hum.2008.142)

Parker, A.L., Waddington, S.N., Buckley, S.M.K., Custers, J., Havenga, M.J.E., van Rooijen, N., Goudsmit, J., Mcvey, J.H., Nicklin, S.A. and Baker, A.H. (2009) Effect of neutralizing sera on factor X-mediated adenovirus serotype 5 gene transfer. Journal of Virology, 83(1), pp. 479-483. (doi: 10.1128/JVI.01878-08)

Greig, J.A. et al. (2009) Influence of Coagulation Factor X on In Vitro and In Vivo Gene Delivery by Adenovirus (Ad) 5, Ad35, and Chimeric Ad5/Ad35 Vectors. Molecular Therapy, 17(10), pp. 1683-1691. (doi: 10.1038/mt.2009.152)

Lenaerts, L., Mcvey, J., Baker, A., Denby, L., Nicklin, S., Verbeken, E. and Naesens, L. (2009) Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting. Journal of Gene Medicine, 11(2), pp. 119-127. (doi: 10.1002/jgm.1283)

Masson, R. et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53(4), pp. 694-700. (doi: 10.1161/HYPERTENSIONAHA.108.122333)

2008

Parker, A.L., Nicklin, S.A. and Baker, A.H. (2008) Interactions of adenovirus vectors with blood: implications for intravascular gene therapy applications. Current Opinion in Molecular Therapeutics, 10(5), pp. 439-448.

Graham, T., McIntosh, J., Work, L. , Nathwani, A. and Baker, A. (2008) Performance of AAV8 vectors expressing human factor IX from a hepatic-selective promoter following intravenous injection into rats. Genetic Vaccines and Therapy, 6(1), p. 9. (doi: 10.1186/1479-0556-6-9)

White, K. et al. (2008) Engineering adeno-associated virus 2 vectors for targeted gene delivery to atherosclerotic lesions. Gene Therapy, 15(6), pp. 443-451. (doi: 10.1038/sj.gt.3303077)

Waddington, S. et al. (2008) Adenovirus serotype 5 hexon mediates liver gene transfer. Cell, 132(3), pp. 397-409. (doi: 10.1016/j.cell.2008.01.016)

Miller, A. M., Xu, D., Asquith, D. L., Denby, L., Li, Y., Sattar, N. , Baker, A. H., McInnes, I. B. and Liew, F. Y. (2008) IL-33 reduces the development of atherosclerosis. Journal of Experimental Medicine, 205(2), pp. 339-346. (doi: 10.1084/jem.20071868) (PMID:18268038) (PMCID:PMC2271006)

Baker, A. (2008) Interaction of Ad5 with blood coagulation factor X mediates liver gene transfer. Human Gene Therapy, 19(10), pp. 1072-1073.

Benest, A.V., Stone, O.A., Miller, W.H., Glover, C.P., Uney, J.B., Baker, A.H., Harper, S.J. and Bates, D.O. (2008) Arteriolar genesis and angiogenesis induced by endothelial nitric oxide synthase overexpression results in a mature vasculature. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(8), pp. 1462-1468. (doi: 10.1161/ATVBAHA.108.169375)

Buckley, S. et al. (2008) Luciferin Detection After Intranasal Vector Delivery Is Improved by Intranasal Rather Than Intraperitoneal Luciferin Administration. Human Gene Therapy, 19(10), pp. 1050-1056.

Flores-Munoz, M., Baker, A. and Nicklin, S. (2008) Development of a gene transfer vector expressing angiotensin 1-7 and assessment of its effects on cardiac hypertrophy. Journal of Human Hypertension, 22(10), p. 723.

Kane, N.M., McRae, S., Denning, C. and Baker, A.H. (2008) Viral and non-viral gene delivery and its role in pluripotent stem cell engineering. Drug Discovery Today: Technologies, 5(4), e107-e115. (doi: 10.1016/j.ddtec.2008.10.002)

Kritz Wilson, A.B., Yu, J., Wright, P.L., Wan, S., George, S.J., Halliday, C., Kang, N., Sessa, W.C. and Baker, A.H. (2008) In Vivo Modulation of Nogo-B Attenuates Neointima Formation. Molecular Therapy, 16(11), pp. 1798-1804. (doi: 10.1038/mt.2008.188)

Nicklin, S. and Baker, A. (2008) Efficient Vascular Endothelial Gene Transfer Following Intravenous Adenovirus Delivery. Molecular Therapy, 16(12), pp. 1904-1905. (doi: 10.1038/mt.2008.226)

Parker, A., Parker, A., Mcvey, J., Waddington, S., Buckley, S., Francischetti, I., Monteiro, R., Nicklin, S. and Baker, A. (2008) An exosite within the human FX serine protease domain mediates cell transduction of AD5: FX complexes. Human Gene Therapy, 19(4), p. 34.

Wang, H. et al. (2008) In Vitro and In Vivo Properties of Adenovirus Vectors with Increased Affinity to CD46. Journal of Virology, 82(21), pp. 10567-10579.

2007

Waddington, S.N., Parker, A.L., Havenga, M., Nicklin, S.A., Buckley, S.M., McVey, J.H. and Baker, A.H. (2007) Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: Fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5. Journal of Virology, 81(17), pp. 9568-9571. (doi: 10.1128/JVI.00663-07)

Kritz, A. B., Nicol, C. G., Dishart, K. L., Nelson, R., Holbeck, S., Von Seggern, D. J., Work, L. M., Mcvey, J. H., Nicklin, S. A. and Baker, A. H. (2007) Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop. Molecular Therapy, 15, pp. 741-749. (doi: 10.1038/sj.mt.6300094)

Baker, A.H. et al. (2007) Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia. Proceedings of the National Academy of Sciences of the United States of America, 104, pp. 3597-3602. (doi: 10.1073/pnas.0611112104)

Baker, A., Mcvey, J., Waddington, S., Di Paolo, N. and Shayakhmetov, D. (2007) The influence of blood on in vivo adenovirus bio-distribution and transduction. Molecular Therapy, 15(8), pp. 1410-1416. (doi: 10.1038/sj.mt.6300206)

Denby, L., Work, L.M., Von Seggern, D.J., Wu, E., Mcvey, J.H., Nicklin, S.A. and Baker, A.H. (2007) Development of renal-targeted vectors through combined in vivo phage display and capsid engineering of adenoviral fibers from serotype 19p. Molecular Therapy, 15(9), pp. 1647-1654. (doi: 10.1038/sj.mt.6300214)

Maffia, P. , Zinselmeyer, B.H., Ialenti, A., Kennedy, S. , Baker, A.H., McInnes, I., Brewer, J.M. and Garside, P. (2007) Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery. Circulation, 115(11), E326-E328. (doi: 10.1161/CIRCULATIONAHA.106.658492) (PMID:17372180)

Magnoni, S., Baker, A., Thomson, S., Jordan, G., George, S., Mccoll, B., McCulloch, J. and Horsburgh, K. (2007) Neuroprotective effect of adenoviral-mediated gene transfer of TIMP-1 and-2 in ischemic brain injury. Gene Therapy, 14, pp. 621-625. (doi: 10.1038/sj.gt.3302894)

Mccoll, B., McGregor, A., Wong, A., Harris, J., Amalfitano, A., Magnoni, S., Baker, A., Dickson, G. and Horsburgh, K. (2007) APOE epsilon 3 gene transfer attenuates brain damage after experimental stroke. Journal of Cerebral Blood Flow and Metabolism, 27, pp. 477-487. (doi: 10.1038/sj.jcbfm.9600361)

Parker, A., Mcvey, J., Doctor, J., Lopez-Franco, O., Waddington, S., Havenga, M., Nicklin, S. and Baker, A. (2007) Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D. Journal of Virology, 81, pp. 3627-3631. (doi: 10.1128/JVI.02786-06)

Sithu, S., English, W., Olson, P., Krubasik, D., Baker, A., Murphy, G. and D'Souza, S. (2007) Membrane-type 1-matrix metalloproteinase regulates intracellular adhesion molecule-1 (ICAM-1)-mediated monocyte transmigration. Journal of Biological Chemistry, 282, pp. 25010-25019. (doi: 10.1074/jbc.M611273200)

Smyth, A., Reid, H., Baker, A. and McGlynn, H. (2007) Modifications of the radiosensitivity of a renal cancer cell line as a consequence of stable TIMP-1 overexpression. International Journal of Radiation Biology, 83, pp. 13-25. (doi: 10.1080/09553000600983136)

Toriseva, M., Ala-aho, R., Karvinen, J., Baker, A., Marjomaki, V., Heino, J. and Kahari, V. (2007) Collagenase-3 (MMP-13) enhances remodeling of three-dimensional collagen and promotes survival of human skin fibroblasts. Journal of Investigative Dermatology, 127, pp. 49-59.

Van Roy, M., Wielockx, B., Baker, A. and Libert, C. (2007) The use of tissue inhibitors of matrix metalloproteinases to increase the efficacy of a tumor necrosis factor/interferon gamma antitumor therapy. Cancer Gene Therapy, 14, pp. 372-379. (doi: 10.1038/sj.cgt.7701020)

White, K., Nicklin, S. and Baker, A. (2007) Novel vectors for in vivo gene delivery to vascular tissue. Expert Opinion on Biological Therapy, 7(6), pp. 809-821. (doi: 10.1517/14712598.7.6.809)

Yoshida, S. et al. (2007) Metalloproteinase inhibition has differential effects on alloimmunity, autoimmunity, and histopathology in the transplanted lung. Transplantation, 83(6), pp. 799-808. (doi: 10.1097/01.tp.0000258600.05531.5d)

2006

Parker, A.L. et al. (2006) Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes in vitro and in vivo. Blood, 108(8), pp. 2554-2561. (doi: 10.1182/blood-2006-04-008532)

Finan, K. M., Hodge, G., Reynolds, A. M., Hodge, S., Holmes, M. D., Baker, A. H. and Reynolds, P. N. (2006) In vitro susceptibility to the pro-apoptotic effects of TIMP-3 gene delivery translates to greater in vivo efficacy versus gene delivery for TIMPs-1 or-2. Lung Cancer, 53, pp. 273-284. (doi: 10.1016/j.lungcan.2006.06.006) (PMID:16860902)

Perabo, L. et al. (2006) Heparan sulfate proteoglycan binding properties of adeno-associated virus retargeting mutants and consequences for their in vivo tropism. Journal of Virology, 80(14), pp. 7265-7269. (doi: 10.1128/JVI.00076-06)

Baker, A., Yim, A. and Wan, S. (2006) Opportunities for gene therapy in preventing vein graft failure after coronary artery bypass surgery. Diabetes, Obesity and Metabolism, 8(2), pp. 119-124. (doi: 10.1111/j.1463-1326.2005.00494.x) (PMID:16448515)

de Nooijer, R., Verkleij, C.J.N., der Thusen, J.H., Jukema, J.W., van der Wall, E.E., van Berkel, T.J.C., Baker, A.H. and Biessen, E.A.L. (2006) Lesional overexpression of matrix metalloproteinase-9 promotes intraplaque hemorrhage in advanced lesions but not at earlier stages of atherogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology, 26, pp. 340-346. (doi: 10.1161/01.ATV.0000197795.56960.64)

George, S., Channon, K. and Baker, A. (2006) Gene therapy and coronary artery bypass grafting: Current perspectives. Current Opinion in Molecular Therapeutics, 8, pp. 288-294.

Heymans, S. et al. (2006) Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditis. Circulation, 114, pp. 565-573. (doi: 10.1161/CIRCULATIONAHA.105.591032)

Johnson, J., Baker, A., Oka, K., Chan, L., Newby, A., Jackson, C. and George, S. (2006) Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2 - Involvement of macrophage migration and apoptosis. Circulation, 113, pp. 2435-2444. (doi: 10.1161/CIRCULATIONAHA.106.613281)

Kim, M., Bodenstine, T., Sumerel, L., Rivera, A., Baker, A. and Douglas, J. (2006) Tissue inhibitor of metalloproteinases-2 improves antitumor efficacy of a replicating adenovirus in vivo. Cancer Biology and Therapy, 5, pp. 1647-1653.

Parker, A. et al. (2006) Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes. Blood, 108, pp. 2554-2561. (doi: 10.1182/blood-2006-04-008532)

Work, L.M. et al. (2006) Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses. Molecular Therapy, 13(4), pp. 683-693. (doi: 10.1016/j.ymthe.2005.11.013)

2005

Akowuah, E. et al. (2005) Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model. Gene Therapy, 12, pp. 1154-1157. (doi: 10.1038/sj.gt.3302498)

Baker, A., Kritz, A., Work, L., Nicklin, S. and Nicklin, A. (2005) Cell-selective viral gene delivery vectors for the vasculature. Experimental Physiology, 90(1), pp. 27-31. (doi: 10.1113/expphysiol.2004.028126)

Denby, L., Nicklin, S.A. and Baker, A.H. (2005) Adeno-associated virus (AAV)-7 and-8 poorly transduce vascular endothelial cells and are sensitive to proteasomal degradation. Gene Therapy, 12, pp. 1534-1538. (doi: 10.1038/sj.gt.3302564)

Heymans, S., Lupu, F., Terclavers, S., Vanwetswinkel, B., Herbert, J., Baker, A., Collen, D., Carmeliet, P. and Moons, L. (2005) Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice. American Journal of Pathology, 166(1), pp. 15-25.

Lovelock, J.D., Baker, A.H., Gao, F., Dong, J.F., Bergeron, A.L., McPheat, W., Sivasubramanian, N. and Mann, D.L. (2005) Heterogeneous effects of tissue inhibitors of matrix metalloproteinases on cardiac fibroblasts. American Journal of Physiology: Heart and Circulatory Physiology, 288, H461-H468. (doi: 10.1152/ajpheart.00402.2004)

Miller, W. , Brosnan, M.J., Graham, D., Nicol, C.G., Morecroft, I., Channon, K.M., Danilov, S.M., Reynolds, P.N., Baker, A.H. and Dominiczak, A.F. (2005) Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats. Molecular Therapy, 12(2), pp. 321-327. (doi: 10.1016/j.ymthe.2005.02.025)

Miller, W.H. , Nicklin, S.A. , Baker, A.H. and Dominiczak, A. (2005) Gene transfer and cardiovascular system. In: Raizada, M.K., Paton, J.F.R., Kasparov, S. and Katovich, M.J. (eds.) Cardiovascular Genomics. Series: Contemporary cardiology. Humana Press: Totowa, NJ, USA, pp. 175-196. ISBN 9781588294005

Nicklin, S., Wu, E., Nemerow, G. and Baker, A. (2005) The influence of adenovirus fiber structure and function on vector development for gene therapy. Molecular Therapy, 12(3), pp. 384-393. (doi: 10.1016/j.ymthe.2005.05.008)

Parker, A., Fisher, K., Oupicky, D., Read, M., Nicklin, S., Baker, A. and Seymour, L. (2005) Enhanced gene transfer activity of peptide-targeted gene-delivery vectors. Journal of Drug Targeting, 13, pp. 39-51. (doi: 10.1080/10611860400020449)

White, S., Simmonds, R., Lane, D. and Baker, A. (2005) Efficient isolation of peptide ligands for the endothelial cell protein C receptor (EPCR) using candidate receptor phage display biopanning. Peptides, 26, pp. 1264-1269. (doi: 10.1016/j.peptides.2005.01.015)

2004

Work, L.M. , Reynolds, P. N. and Baker, A. H. (2004) Improved gene delivery to human saphenous vein cells and tissue using a peptide-modified adenoviral vector. Genetic Vaccines and Therapy, 2(1), p. 14. (doi: 10.1186/1479-0556-2-14)

Baker, A. (2004) Designing gene delivery vectors for cardiovascular gene therapy. Progress in Biophysics and Molecular Biology, 84, pp. 279-299. (doi: 10.1016/j.pbiomolbio.2003.11.006)

Denby, L., Work, L.M., Graham, D. , Hsu, C., Von Seggern, D.J., Nicklin, S.A. and Baker, A.H. (2004) Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo. Human Gene Therapy, 15(11), pp. 1054-1064.

Elezkurtaj, S., Kopitz, C., Baker, A., Perez-Canto, A., Arlt, M., Khokha, R., Gansbacher, B., Anton, M., Brand, K. and Kruger, A. (2004) Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis. Journal of Gene Medicine, 6, pp. 1228-1237. (doi: 10.1002/jgm.637)

Magnoni, S., Baker, A., George, S., Duncan, W., Kerr, L., McCulloch, J. and Horsburgh, K. (2004) Differential alterations in the expression and activity of matrix metalloproteinases 2 and 9 after transient cerebral ischemia in mice. Neurobiology of Disease, 17, pp. 188-197. (doi: 10.1016/j.nbd.2004.07.020)

Nicklin, S., White, S., Nicol, C., Von Seggern, D. and Baker, A. (2004) In vitro and in vivo characterisation of endothelial cell selective adenoviral vectors. Journal of Gene Medicine, 6, pp. 300-308. (doi: 10.1002/jgm.526)

Nicol, C., Graham, D., Miller, W., White, S., Smith, T., Nicklin, S., Stevenson, S. and Baker, A. (2004) Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats. Molecular Therapy, 10(2), pp. 344-354. (doi: 10.1016/j.ymthe.2004.05.020)

Papadakis, E., Nicklin, S., Baker, A. and White, S. (2004) Promoters and control elements: Designing expression cassettes for gene therapy. Current Gene Therapy, 4, pp. 89-113.

Wan, S., George, S., Nicklin, S., Yim, A. and Baker, A. (2004) Overexpression of p53 increases lumen size and blocks neointima formation in porcine interposition vein grafts. Molecular Therapy, 9(5), pp. 689-698. (doi: 10.1016/j.ymthe.2004.02.005)

White, S., Nicklin, S., Buning, H., Brosnan, M., Leike, K., Papadakis, E., Hallek, M. and Baker, A. (2004) Targeted gene delivery to vascular tissue in vivo by tropism-modified adeno-associated virus vectors. Circulation, 109, pp. 513-519. (doi: 10.1161/01.CIR.0000109697.68832.5D)

Work, L.M., Nicol, C.G., Denby, L. and Baker, A.H. (2004) In vivo biopanning: a methodological approach to identifying novel targeting ligands for delivery of biological agents to the vasculature. In: Fennell, J.P. and Baker, A.H. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular medicine (108). Humana Press: Totowa, NJ, USA, pp. 395-413. ISBN 9781588293237 (doi: 10.1385/1-59259-850-1:395)

Work, L., Nicklin, S., Brain, N., Dishart, K., Von Seggern, D., Hallek, M., Buning, H. and Baker, A. (2004) Development of efficient viral vectors selective for vascular smooth muscle cells. Molecular Therapy, 9(2), pp. 198-208. (doi: 10.1016/j.ymthe.2003.11.006)

Work, L., Ritchie, N., Nicklin, S., Reynolds, P. and Baker, A. (2004) Dual targeting of gene delivery by genetic modification of adenovirus serotype 5 fibers and cell-selective transcriptional control. Gene Therapy, 11, pp. 1296-1300. (doi: 10.1038/sj.gt.3302292)

2003

Dishart, K.L., Work, L.M. , Denby, L. and Baker, A.H. (2003) Gene therapy for cardiovascular disease. Journal of Biomedicine and Biotechnology, 2003(2), pp. 138-148. (doi: 10.1155/S1110724303209086)

Ahonen, M., Poukkula, M., Baker, A., Kashiwagi, M., Nagase, H., Eriksson, J. and Kahari, V. (2003) Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors. Oncogene, 22, pp. 2121-2134. (doi: 10.1038/sj.onc.1206292)

Baker, A. (2003) Targeting AAV vectors. Molecular Therapy, 7(4), pp. 433-434. (doi: 10.1016/S1525-0016(03)00072-8)

Buning, H., Nicklin, S., Perabo, L., Hallek, M. and Baker, A. (2003) AAV-based gene transfer. Current Opinion in Molecular Therapeutics, 5, pp. 367-375.

de Nigris, F., Lerman, A., Ignarro, L., Williams-Ignarro, S., Sica, V., Baker, A., Lerman, L., Geng, Y. and Napoli, C. (2003) Oxidation-sensitive mechanisms, vascular apoptosis and atherosclerosis. Trends in Molecular Medicine, 9, pp. 351-359. (doi: 10.1016/S1471-4914(03)00139-4)

Dishart, K.L. et al. (2003) Third-generation lentivirus vectors efficiently transduce and phenotypically modify vascular cells: implications for gene therapy. Journal of Molecular and Cellular Cardiology, 35(7), pp. 739-748. (doi: 10.1016/S0022-2828(03)00136-6)

Gruss, C. et al. (2003) Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice. Journal of Investigative Dermatology, 120, pp. 683-692.

Lambert, V. et al. (2003) MMP-2 and MMP-9 synergize in promoting choroidal neovascularization. FASEB Journal, 17(15), pp. 2290-2292. (doi: 10.1096/fj.03-0113fje)

MacKenzie, C., Paul, A., Wilson, S., de Martin, R., Baker, A. and Plevin, R. (2003) Enhancement of lipopolysaccharide-stimulated JNK activity in rat aortic smooth muscle cells by pharmacological and adenovirusmediated inhibition of inhibitory kappa B kinase signalling. British Journal of Pharmacology, 139, pp. 1041-1049. (doi: 10.1038/sj.bjp.0705330)

Nicklin, S.A. and Baker, A.H. (2003) Development of targeted viral vectors for cardiovascular gene therapy. In: Setlow, J.K. (ed.) Genetic Engineering, Principles and Methods. Kluwer Academic: Dordrecht, The Netherlands, pp. 15-49. ISBN 9780306477768

Nicklin, S., Dishart, K., Buening, H., Reynolds, P., Hallek, M., Nemerow, G., Von Seggern, D. and Baker, A. (2003) Transductional and transcriptional targeting of cancer cells using genetically engineered viral vectors. Cancer Letters, 201, pp. 165-173. (doi: 10.1016/j.canlet.2003.07.003)

Qi, J., Ebrahem, Q., Moore, N., Murphy, G., Claesson-Welsh, L., Bond, M., Baker, A. and Anand-Apte, B. (2003) A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2. Nature Medicine, 9, pp. 407-415. (doi: 10.1038/nm846)

Tan, H., Heywood, D., Ralph, G., Bienemann, A., Baker, A. and Uney, J. (2003) Tissue inhibitor of metalloproteinase 1 inhibits excitotoxic cell death in neurons. Molecular and Cellular Neuroscience, 22, pp. 98-106. (doi: 10.1016/S1044-7431(02)00024-6)

Vieillard-Baron, A., Frisdal, E., Raffestin, B., Baker, A., Eddahibi, S., Adnot, S. and D'Ortho, M. (2003) Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer limits monocrotaline-induced pulmonary vascular remodeling in rats. Human Gene Therapy, 14, pp. 861-869.

Work, L., Nicklin, S. and Baker, A. (2003) Targeting Gene Therapy Vectors to the Vascular Endothelium. Current Atherosclerosis Reports, 5(3), pp. 163-170.

2002

Majid, M. A., Smith, V. A., Easty, D. L., Baker, A. H. and Newby, A. C. (2002) Sorsby's fundus dystrophy mutant tissue inhibitors of metalloproteinase-3 induce apoptosis of retinal pigment epithelial and MCF-7 cells. FEBS Letters, 529(2-3), pp. 281-285. (doi: 10.1016/S0014-5793(02)03359-8)

Van de Louw, A., Jean, D., Frisdal, E., Cerf, C., D'Ortho, M.-P., Baker, A. H., Lafuma, C., Duvaldestin, P., Harf, A. and Delclaux, C. (2002) Neutrophil proteinases in hydrochloric acid- and endotoxin-induced acute lung injury: Evaluation of interstitial protease activity by in situ zymography. Laboratory Investigation, 82(2), pp. 133-145. (doi: 10.1038/labinvest.3780406) (PMID:11850527)

Ahonen, M., Ala-aho, R., Baker, A., George, S., Grenman, R., Saarialho-Kere, U. and Kahari, V. (2002) Antitumor activity and bystander effect of adenovirally delivered tissue inhibitor of metalloproteinases-3. Molecular Therapy, 5(6), pp. 705-715. (doi: 10.1006/mthe.2002.0606)

Ala-aho, R., Johansson, N., Baker, A. and Kahari, V. (2002) Expression of collagenase-3 (MMP-13) enhances invasion of human fibrosarcoma HT-1080 cells. International Journal of Cancer, 97(3), pp. 283-289. (doi: 10.1002/ijc.1619)

Bainbridge, J., Mistry, A., De Alwis, M., Paleolog, E., Baker, A., Thrasher, A. and Ali, R. (2002) Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1. Gene Therapy, 9, pp. 320-326. (doi: 10.1038/sj/gt/3301680)

Baker, A. (2002) Development and use of gene transfer for treatment of cardiovascular disease. Journal of Cardiac Surgery, 17(6), pp. 543-548. (doi: 10.1046/j.1540-8191.2002.01011.x)

Baker, A. (2002) Gene therapy for bypass graft failure and restenosis. Pathophysiology of Haemostasis and Thrombosis, 32, pp. 389-391.

Baker, A., Edwards, D. and Murphy, G. (2002) Metalloproteinase inhibitors: biological actions and therapeutic opportunities. Journal of Cell Science, 115, pp. 3719-3727. (doi: 10.1242/jcs.00063)

Bauerschmitz, G., Nettelbeck, D., Kanerva, A., Baker, A., Hemminki, A., Reynolds, P. and Curiel, D. (2002) The flt-1 promoter for transcriptional targeting of teratocarcinoma. Cancer Research, 62, pp. 1271-1274.

Bond, M., Murphy, G., Bennett, M., Newby, A. and Baker, A. (2002) Tissue inhibitor of metalloproteinase-3 induces a Fas-associated death domain-dependent type II apoptotic pathway. Journal of Biological Chemistry, 277, pp. 13787-13795. (doi: 10.1074/jbc.M111507200)

Fennell, J., Brosnan, M., Frater, A., Hamilton, C., Alexander, M., Nicklin, S., Heistad, D., Baker, A. and Dominiczak, A. (2002) Adenovirus-mediated overexpression of extracellular superoxide dismutase improves endothelial dysfunction in a rat model of hypertension. Gene Therapy, 9(2), pp. 110-117. (doi: 10.1038/sj.gt.3301633)

Majid, M., Smith, V., Easty, D., Baker, A. and Newby, A. (2002) Adenovirus mediated gene delivery of tissue inhibitor of metalloproteinases-3 induces death in retinal pigment epithelial cells. British Journal of Ophthalmology, 86(1), pp. 97-101.

Nicklin, S. and Baker, A. (2002) Tropism-Modified Adenoviral and Adeno-Associated Viral Vectors for Gene Therapy. Current Gene Therapy, 2(3), pp. 273-293.

Turunen, M. et al. (2002) Peptide-retargeted adenovirus encoding a tissue inhibitor of metalloproteinase-1 decreases restenosis after intravascular gene transfer. Molecular Therapy, 6(3), pp. 306-312. (doi: 10.1006/mthe.2002.0668)

Work, L. M. , Nicklin, S. A. , White, S. J. and Baker, A. H. (2002) Use of phage display to identify novel peptides for targeted gene therapy. In: Phillips, M. I. (ed.) Gene Therapy Methods. Series: Methods in enzymology (346). Academic Press: San Diego, California ; London, pp. 157-176. ISBN 9780121822477 (doi: 10.1016/S0076-6879(02)46055-7)

2001

Apparailly, F., Noel, D., Millet, V., Baker, A., Lisignoli, G., Jacquet, C., Kaiser, M., Sany, J. and Jorgensen, C. (2001) Paradoxical effects of tissue inhibitor of metalloproteinases 1 gene transfer in collagen-induced arthritis. Arthritis and Rheumatism, 44(6), pp. 1444-1454. (doi: 10.1002/1529-0131(200106)44:6<1444::AID-ART240>3.0.CO;2-Q)

Bond, M., Chase, A., Baker, A. and Newby, A. (2001) Inhibition of transcription factor NF-kappa B reduces matrix metalloproteinase-1,-3 and-9 production by vascular smooth muscle cells. Cardiovascular Research, 50, pp. 556-565. (doi: 10.1016/S0008-6363(01)00220-6)

George, S., Angelini, G., Capogrossi, M. and Baker, A. (2001) Wild-type p53 gene transfer inhibits neointima formation in human saphenous vein by modulation of smooth muscle cell migration and induction of apoptosis. Gene Therapy, 8(9), pp. 668-676. (doi: 10.1038/sj.gt.3301431)

Hu, Y.H., Baker, A.H., Zou, Y.P., Newby, A.C. and Xu, Q.B. (2001) Local gene transfer of tissue inhibitor of metalloproteinase-2 influences vein graft remodeling in a mouse model. Arteriosclerosis, Thrombosis, and Vascular Biology, 21(8), pp. 1275-1280. (doi: 10.1161/hq0801.093658)

Nicklin, S., Buening, H., Dishart, K., De Alwis, M., Girod, A., Hacker, U., Thrasher, A., Ali, R., Hallek, M. and Baker, A. (2001) Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells. Molecular Therapy, 4(2), pp. 174-181. (doi: 10.1006/mthe.2001.0424)

Nicklin, S., Reynolds, P., Brosnan, M., White, S., Curiel, D., Dominiczak, A. and Baker, A. (2001) Analysis of cell-specific promoters for viral gene therapy targeted at the vascular endothelium. Hypertension, 38(1), pp. 65-70. (doi: 10.1161/01.HYP.38.1.65)

Nicklin, S., Von Seggern, D., Work, L., Pek, D., Dominiczak, A., Nemerow, G. and Baker, A. (2001) Ablating adenovirus type 5 fiber-CAR binding and HI loop insertion of the SIGYPLP peptide generate an endothelial cell-selective adenovirus. Molecular Therapy, 4(6), pp. 534-542. (doi: 10.1006/mthe.2001.0489)

Reynolds, P., Nicklin, S., Kaliberova, L., Boatman, B., Grizzle, W., Balyasnikova, I., Baker, A., Danilov, S. and Curiel, D. (2001) Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo. Nature Biotechnology, 19, pp. 838-842.

White, S., Nicklin, S., Sawamura, T. and Baker, A. (2001) Identification of peptides that target the endothelial cell-specific LOX-1 receptor. Hypertension, 37, pp. 449-455.

2000

Nicklin, S. A. , White, S. J., Watkins, S. J., Hawkins, R. E. and Baker, A. H. (2000) Selective targeting of gene transfer to vascular endothelial cells by use of peptides isolated by phage display. Circulation, 102(2), pp. 231-237. (doi: 10.1161/01.CIR.102.2.231) (PMID:10889136)

Bond, M., Murphy, G., Bennett, M., Amour, A., Knauper, V., Newby, A. and Baker, A. (2000) Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus - Metalloproteinase inhibition is associated with proapoptotic activity. Journal of Biological Chemistry, 275(52), pp. 41358-41363. (doi: 10.1074/jbc.M007929200)

1999

Nicklin, S. A. and Baker, A. H. (1999) Simple methods for preparing recombinant adenoviruses for high-efficiency transduction of vascular cells. In: Baker, A. H. (ed.) Vascular Disease: Molecular Biology and Gene Transfer Protocols. Series: Methods in molecular medicine (30). Humana Press: Totowa, NJ, pp. 271-284. ISBN 9780896037311 (doi: 10.1385/1-59259-247-3:271)

Articles

Bates, E. A. et al. (2021) In vitro and in vivo evaluation of human adenovirus type 49 as a vector for therapeutic applications. Viruses, 13(8), 1483. (doi: 10.3390/v13081483)

Doszpoly, A., de la Cuesta, F., Lopez-Gordo, E., Bénézech, C., Nicklin, S. A. and Baker, A. H. (2019) Human adenovirus serotype 5 is sensitive to IgM-independent neutralization in vitro and in vivo. Viruses, 11(7), 616. (doi: 10.3390/v11070616) (PMID:31284434) (PMCID:PMC6669743)

Pinel, K., Diver, L. A., White, K., McDonald, R. A. and Baker, A. H. (2019) Substantial dysregulation of miRNA passenger strands underlies the vascular response to injury. Cells, 8(2), 83. (doi: 10.3390/cells8020083) (PMID:30678104) (PMCID:PMC6406808)

Low, E. L., Baker, A. H. and Bradshaw, A. C. (2019) TGFβ, smooth muscle cells and coronary artery disease: a review. Cellular Signalling, 53, pp. 90-101. (doi: 10.1016/j.cellsig.2018.09.004) (PMID:30227237) (PMCID:PMC6293316)

Guzik, T. J. et al. (2018) What matters in Cardiovascular Research? Scientific discovery driving clinical delivery. Cardiovascular Research, 114(12), pp. 1565-1568. (doi: 10.1093/cvr/cvy214)

MacAskill, M. G. et al. (2018) Robust revascularization in models of limb ischemia using a clinically translatable human stem cell-derived endothelial cell product. Molecular Therapy, 26(7), pp. 1669-1684. (doi: 10.1016/j.ymthe.2018.03.017) (PMID:29703701) (PMCID:PMC6035339)

English, W. R., Ireland-Zecchini, H., Baker, A. H., Littlewood, T. D., Bennett, M. R. and Murphy, G. (2018) Tissue Inhibitor of Metalloproteinase–3 (TIMP-3) induces FAS dependent apoptosis in human vascular smooth muscle cells. PLoS ONE, 13(4), e0195116. (doi: 10.1371/journal.pone.0195116) (PMID:29617412) (PMCID:PMC5884528)

Duffy, M. R. et al. (2018) Generation and characterization of a novel candidate gene therapy and vaccination vector based on human species D adenovirus type 56. Journal of General Virology, 99(1), pp. 135-147. (doi: 10.1099/jgv.0.000978) (PMID:29154744)

Lopez-Gordo, E., Doszpoly, A., Duffy, M. R., Coughlan, L., Bradshaw, A. C. , White, K. M., Denby, L., Nicklin, S. A. and Baker, A. H. (2017) Defining a novel role for the coxsackie and adenovirus receptor in human adenovirus serotype 5 transduction in vitro in the presence of mouse serum. Journal of Virology, 91(12), e02487-16. (doi: 10.1128/JVI.02487-16) (PMID:28381574) (PMCID:PMC5446653)

MacAskill, M. G., Tavares, A. S., Wu, J., Lucatelli, C., Mountford, J. C., Baker, A. H., Newby, D. and Hadoke, P. W.F. (2017) PET cell tracking using (18)F-FLT is not limited by local reuptake of free radiotracer. Scientific Reports, 7, 44233. (doi: 10.1038/srep44233) (PMID:28287126) (PMCID:PMC5347009)

Finan, K. M., Hodge, G., Reynolds, A. M., Hodge, S., Holmes, M. D., Baker, A. H. and Reynolds, P. N. (2016) Corrigendum to "In vitro susceptibility to the pro-apoptotic effects of TIMP-3 gene delivery translates to greater in vivo efficacy versus gene delivery for TIMPs-1 or -2" [Lung Cancer 53 (3) (September 2006) 273-284]. Lung Cancer, 101, p. 149. (doi: 10.1016/j.lungcan.2016.06.002) (PMID:27312600)

Deng, L., Bradshaw, A. C. and Baker, A. H. (2016) Role of noncoding RNA in vascular remodelling. Current Opinion in Lipidology, 27(5), pp. 439-448. (doi: 10.1097/MOL.0000000000000336) (PMID:27472407)

Lavery, C. A., Kurowska-Stolarska, M. , Holmes, W. , Donnelly, I., Caslake, M., Collier, A., Baker, A. H. and Miller, A. M. (2016) miR-34a-/- mice are susceptible to diet-induced obesity. Obesity, 24(8), pp. 1741-1751. (doi: 10.1002/oby.21561) (PMID:27377585) (PMCID:PMC4979678)

Duffy, M.R., Doszpoly, A., Turner, G., Nicklin, S.A. and Baker, A.H. (2016) The relevance of coagulation factor X protection of adenoviruses in human sera. Gene Therapy, 23(7), pp. 592-596. (doi: 10.1038/gt.2016.32) (PMID:27014840) (PMCID:PMC4940928)

Ballantyne, M. D. et al. (2016) Smooth muscle enriched long noncoding RNA (SMILR) regulates cell proliferation. Circulation, 133(21), pp. 2050-2065. (doi: 10.1161/circulationaha.115.021019) (PMID:27052414) (PMCID:PMC4872641)

Ballantyne, M.D., McDonald, R.A. and Baker, A.H. (2016) lncRNA/MicroRNA interactions in the vasculature. Clinical Pharmacology and Therapeutics, 99(5), pp. 494-501. (doi: 10.1002/cpt.355) (PMID:26910520)

Stevens, H. C., Deng, L., Grant, J. S., Pinel, K., Thomas, M., Morrell, N. W., MacLean, M. R. and Baker, A. (2016) Regulation and function of miR-214 in pulmonary arterial hypertension. Pulmonary Circulation, 6(1), pp. 109-117. (doi: 10.1086/685079) (PMID:27162619) (PMCID:PMC4860547)

Alonso-Padilla, J., Papp, T., Kaján, G. L., Benkő, M., Havenga, M., Lemckert, A., Harrach, B. and Baker, A. H. (2016) Development of novel adenoviral vectors to overcome challenges observed with HAdV-5 based constructs. Molecular Therapy, (doi: 10.1038/mt.2015.194) (PMID:26478249) (PMCID:PMC4754553)

Boulberdaa, M. et al. (2016) A role for the long non-coding RNA SENCR in commitment and function of endothelial cells. Molecular Therapy, 24(5), pp. 978-990. (doi: 10.1038/mt.2016.41) (PMID:26898221) (PMCID:PMC4876031)

Brittan, M., Hunter, A., Boulberdaa, M., Fujisawa, T., Skinner, E. M., Shah, A. S., Baker, A.H. and Mills, N. L. (2015) Impaired vascular function and repair in patients with premature coronary artery disease. European Journal of Preventive Cardiology, 22(12), pp. 1557-1566. (doi: 10.1177/2047487315600169) (PMID:26276790)

Deng, L. et al. (2015) MicroRNA-143 activation regulates smooth muscle and endothelial cell crosstalk in pulmonary arterial hypertension. Circulation Research, 117(10), pp. 870-883. (doi: 10.1161/CIRCRESAHA.115.306806) (PMID:26311719) (PMCID:PMC4620852)

McDonald, R. A., Pinel, K. and Baker, A. H. (2015) Micro(RNA) management of smooth muscle cell phenotype and response to vascular injury. Cardiovascular Research, 107(4), pp. 403-406. (doi: 10.1093/cvr/cvv199) (PMID:26224571)

Schneider, M. D., Baker, A. H. and Riley, P. (2015) Hopx and the cardiomyocyte parentage. Molecular Therapy, 23(9), pp. 1420-1422. (doi: 10.1038/mt.2015.140) (PMID:26321185)

Wallace, E. , Morrell, N. W., Yang, X. D., Long, L., Stevens, H., Nilsen, M., Loughlin, L., Mair, K. M., Baker, A. H. and MacLean, M. R. (2015) A sex-specific microRNA-96/5HT1B Axis influences development of pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine, 191(12), pp. 1432-1442. (doi: 10.1164/rccm.201412-2148OC) (PMID:25871906) (PMCID:PMC4476563)

McDonald, R. A. et al. (2015) Reducing in-stent restenosis therapeutic manipulation of miRNA in vascular remodeling and inflammation. Journal of the American College of Cardiology, 65(21), pp. 2314-2327. (doi: 10.1016/j.jacc.2015.03.549) (PMID:26022821) (PMCID:PMC4444526)

Dakin, R. S., Parker, A. L., Delles, C. , Nicklin, S. A. and Baker, A. H. (2015) Efficient transduction of primary vascular cells by the rare adenovirus serotype 49 vector. Human Gene Therapy, 26(5), pp. 312-319. (doi: 10.1089/hum.2015.019) (PMID:25760682) (PMCID:PMC4442572)

Nicklin, S. A. , Griesenbach, U. and Baker, A. H. (2015) Special focus issue on the annual meeting of the british society for gene and cell therapy. Human Gene Therapy, 26(5), pp. 247-248. (doi: 10.1089/hum.2015.2500) (PMID:25989311)

Duffy, M., Ma, J., Deng, L., Dakin, R. S., Uil, T., Custers, J., Kelly, S. M. , McVey, J. H., Nicklin, S. A. and Baker, A. H. (2015) Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo. PLoS Pathogens, 11(2), e1004673. (doi: 10.1371/journal.ppat.1004673) (PMID:25658827) (PMCID:PMC4450073)

Lopez Gordo, E., Denby, L., Nicklin, S. A. and Baker, A. H. (2014) The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery. Expert Opinion on Drug Delivery, 11(11), pp. 1795-1813. (doi: 10.1517/17425247.2014.938637)

White, K. et al. (2014) Endothelial apoptosis in pulmonary hypertension is controlled by a microRNA/programmed cell death 4/caspase-3 axis. Hypertension, 64(1), pp. 185-194. (doi: 10.1161/HYPERTENSIONAHA.113.03037)

Coughlan, L., Uusi-Kerttula, H., Ma, J., Degg, B. P., Parker, A. L. and Baker, A. H. (2014) Retargeting adenovirus serotype 48 fiber knob domain by peptide incorporation. Human Gene Therapy, 25(4), pp. 385-394. (doi: 10.1089/hum.2014.016) (PMID:24617540)

Baker, A. H. (2014) Adenovirus-based vectors: maximizing opportunities and optimizing a rich diversity of vectors for gene-based therapy. Human Gene Therapy, 25(4), pp. 255-256. (doi: 10.1089/hum.2014.2508)

Denby, L. et al. (2014) MicroRNA-214 antagonism protects against renal fibrosis. Journal of the American Society of Nephrology, 25(1), pp. 65-80. (doi: 10.1681/ASN.2013010072) (PMID:24158985) (PMCID:PMC3871772)

Grant, J. S., Morecroft, I., Dempsie, Y., van Rooij, E., MacLean, M. R. and Baker, A. H. (2013) Transient but not genetic loss of miR-451 attenuates the development of pulmonary arterial hypertension. Pulmonary Circulation, 3(4), pp. 840-850. (doi: 10.1086/674751) (PMID:25006399) (PMCID:PMC4070830)

Grant, J. S., White, K., MacLean, M. R. and Baker, A. H. (2013) MicroRNAs in pulmonary arterial remodeling. Cellular and Molecular Life Sciences, 70(23), pp. 4479-4494. (doi: 10.1007/s00018-013-1382-5)

Ramdas, V., McBride, M. , Denby, L. and Baker, A. H. (2013) Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. American Journal of Pathology, 183(6), pp. 1885-1896. (doi: 10.1016/j.ajpath.2013.08.027)

Scott, E., Loya, K., Mountford, J., Milligan, G. and Baker, A. H. (2013) MicroRNA regulation of endothelial homeostasis and commitment—implications for vascular regeneration strategies using stem cell therapies. Free Radical Biology and Medicine, 64, pp. 52-60. (doi: 10.1016/j.freeradbiomed.2013.04.037)

Duffy, M. R., Parker, A. L., Kalkman, E. R., White, K., Kovalskyy, D., Kelly, S. M. and Baker, A. H. (2013) Identification of novel small molecule inhibitors of adenovirus gene transfer using a high throughput screening approach. Journal of Controlled Release, 170(1), pp. 132-140. (doi: 10.1016/j.jconrel.2013.05.007)

McDonald, R. A. et al. (2013) miRNA-21 is dysregulated in response to vein grafting in multiple models and genetic ablation in mice attenuates neointima formation. European Heart Journal, 34(22), pp. 1636-1643. (doi: 10.1093/eurheartj/eht105)

Baker, A.H., Nicklin, S.A. and Shayakhmetov, D.M. (2013) FX and host defense evasion tactics by adenovirus. Molecular Therapy, 21(6), pp. 1109-1111. (doi: 10.1038/mt.2013.100)

McKimmie, C.S. et al. (2013) An analysis of the function and expression of D6 on lymphatic endothelial cells. Blood, 121(18), pp. 3768-3777. (doi: 10.1182/blood-2012-04-425314)

Baker, A. H. and Delles, C. (2013) Is microRNA-376c a biomarker or mediator of preeclampsia? Hypertension, 61(4), pp. 767-769. (doi: 10.1161/HYPERTENSIONAHA.111.00087)

Bradshaw, A. C. and Baker, A. H. (2013) Gene therapy for cardiovascular disease: perspectives and potential. Vascular Pharmacology, 58(3), pp. 174-181. (doi: 10.1016/j.vph.2012.10.008)

Howard, L., MacKenzie, R. M., Pchelintsev, N. A., McBryan, T., McClure, J. D. , McBride, M. W. , Kane, N. M., Adams, P. D., Milligan, G. and Baker, A. H. (2013) Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment. Stem Cell Research and Therapy, 4(2), Art. 36. (doi: 10.1186/scrt192)

Parker, A.L., White, K.M., Lavery, C.A., Custers, J., Waddington, S.N. and Baker, A.H. (2013) Pseudotyping the adenovirus serotype 5 capsid with both the fibre and penton of serotype 35 enhances vascular smooth muscle cell transduction. Gene Therapy, 20(12), pp. 1158-1164. (doi: 10.1038/gt.2013.44)

Son, D.J. et al. (2013) The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. Nature Communications, 4, (doi: 10.1038/ncomms4000)

White, K. M., Alba, R., Parker, A. L., Wright, A. F., Bradshaw, A. C. , Delles, C. , McDonald, R. A. and Baker, A. H. (2013) Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile. Journal of Cardiothoracic Surgery, 8(183), (doi: 10.1186/1749-8090-8-183)

Bradshaw, A. C. , Coughlan, L., Miller, A. M.., Nicklin, S. A. , Baker, A. H., Alba, R. and van Rooijen, N. (2012) Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses. Journal of Controlled Release, 164(3), pp. 394-402. (doi: 10.1016/j.jconrel.2012.05.025)

Miller, A. M., Xu, D., Asquith, D. L., Denby, L., Li, Y., Sattar, N. , Baker, A. H., McInnes, I. B. and Liew, F. Y. (2012) IL-33 reduces the development of atherosclerosis (vol 205, pg 339, 2008). Journal of Experimental Medicine, 209(13), p. 2515. (doi: 10.1084/jem.2007186820913c)

Coughlan, L. et al. (2012) Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery. Molecular Therapy, 20(12), pp. 2268-2281. (doi: 10.1038/mt.2012.162) (PMID:22929662) (PMCID:PMC3514487)

Chick, H.E. et al. (2012) Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk. Human Gene Therapy, 23(12), pp. 1247-1257. (doi: 10.1089/hum.2012.042)

Kaupisch, A., Kennedy, L., Stelmanis, V., Tye, B., Kane, N.M., Mountford, J.C., Courtney, A. and Baker, A.H. (2012) Derivation of vascular endothelial cells from human embryonic stem cells under GMP-compliant conditions: towards clinical studies in ischaemic disease. Journal of Cardiovascular Translational Research, 5(5), pp. 605-617. (doi: 10.1007/s12265-012-9379-2)

Robinson, H. C. and Baker, A. H. (2012) How do microRNAs affect vascular smooth muscle cell biology? Current Opinion in Lipidology, 23(5), pp. 405-411. (doi: 10.1097/MOL.0b013e32835719a1)

Robertson, K.E., McDonald, R.A., Oldroyd, K.G., Nicklin, S.A. and Baker, A.H. (2012) Prevention of coronary in-stent restenosis and vein graft failure: Does vascular gene therapy have a role? Pharmacology and Therapeutics, 136(1), pp. 23-34. (doi: 10.1016/j.pharmthera.2012.07.002)

Coughlan, L., Vallath, S., Gros, A., Giménez-Alejandre, M., Van Rooijen, N., Thomas, G.J., Baker, A.H., Cascalló, M., Alemany, R. and Hart, I.R. (2012) Combined fiber modifications both to target αvβ6 and detarget the coxsackievirus–adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5. Human Gene Therapy, 23(9), pp. 960-979. (doi: 10.1089/hum.2011.218)

Caruso, P. et al. (2012) A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples. Circulation Research, 111(3), pp. 290-300. (doi: 10.1161/CIRCRESAHA.112.267591)

Baker, A.H. (2012) Spotlight: Andrew Baker, PhD, FAHA, FESC, FRSE: "A strategy of short-term genetic engineering prevented long-term pathological processes in the vein graft". Circulation, 125(21), F121-F123. (doi: 10.1161/CIR.0b013e31825e771f)

Kane, N. M. et al. (2012) Role of MicroRNAs 99b, 181a, and 181b in the differentiation of human embryonic stem cells to vascular endothelial cells. Stem Cells, 30(4), pp. 643-654. (doi: 10.1002/stem.1026)

White, K., Kane, N. M., Milligan, G. and Baker, A. H. (2012) The role of miRNA in stem cell pluripotency and commitment to the vascular endothelial lineage. Microcirculation, 19(3), pp. 196-207. (doi: 10.1111/j.1549-8719.2012.00161.x)

McDonald, R. A., Hata, A., MacLean, M. R., Morrell, N. W. and Baker, A. H. (2012) MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling. Cardiovascular Research, 93(4), pp. 594-604. (doi: 10.1093/cvr/cvr299)

Duffy, M. R., Parker, A. L., Bradshaw, A. C. and Baker, A. H. (2012) Manipulation of adenovirus interactions with host factors for gene therapy applications. Nanomedicine, 7(2), pp. 271-288. (doi: 10.2217/nnm.11.186)

Alba, R., Bradshaw, A.C. , Mestre-Francés, N., Verdier, J.-M., Henaff, D. and Baker, A.H. (2012) Coagulation factor X mediates adenovirus type 5 liver gene transfer in non-human primates (Microcebus murinus). Gene Therapy, 19(1), pp. 109-113. (doi: 10.1038/gt.2011.87)

Coughlan, L., Vallath, S., Gros, A., Giménez-Alejandre, M., Van Rooijen, N., Thomas, G.J., Baker, A.H., Cascalló, M., Alemany, R. and Hart, I.R. (2012) Combined fiber modifications both to target αvβ6 and detarget the coxsackievirus–adenovirus receptor improve virus toxicity profilesIn vivobut fail to improve antitumoral efficacy relative to adenovirus serotype 5. Human Gene Therapy, 23(9), pp. 960-979. (doi: 10.1089/hum.2011.218) (PMID:22708837)

Duffy, M.R., Kalkman, E. and Baker, A.H. (2012) Identification of a novel small molecule inhibitor of FX-mediated Ad5 gene transfer for gene therapy applications. Molecular Therapy, 20(S1), S117-S117. (doi: 10.1038/mt.2012.86)

Flores, M., Graham, D. , Dominiczak, A.F. , Milligan, G. , Baker, A.H. and Nicklin, S.A. (2012) Angiotensin-(1-9) antagonises Angiotensin II-induced cardiac remodeling via the angiotensin type 2 receptor. Proceedings of the Physiological Society, 27, C1.

Flores, M., Graham, D. , Dominiczak, A. F. , Milligan, G. , Baker, A. H. and Nicklin, S. A. (2012) Abstract 231: angiotensin-(1-9) antagonises cardiac remodelling in a mouse model of Angiotensin Ii-induced hypertension. Hypertension, 60, A231.

Morecroft, I., White, K., Caruso, P., Nilsen, M., Loughlin, L., Alba, R., Reynolds, P.N., Danilov, S.M., Baker, A.H. and MacLean, M.R. (2012) Gene therapy by targeted adenovirus-mediated knockdown of pulmonary endothelial Tph1 attenuates hypoxia-induced pulmonary hypertension. Molecular Therapy, 20(8), pp. 1516-1528. (doi: 10.1038/mt.2012.70)

Rahim, A.A. et al. (2012) In utero administration of Ad5 and AAV pseudotypes to the fetal brain leads to efficient, widespread and long-term gene expression. Gene Therapy, 19(9), pp. 936-946. (doi: 10.1038/gt.2011.157)

Ialenti, A. et al. (2011) Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(11), pp. 2448-2454. (doi: 10.1161/ATVBAHA.111.230078) (PMID:21852559)

Howard, L., Kane, N., Milligan, G. and Baker, A. H. (2011) MicroRNAs regulating cell pluripotency and vascular differentiation. Vascular Pharmacology, 55(4), pp. 69-78. (doi: 10.1016/j.vph.2011.08.002)

Duffy, M.R., Bradshaw, A.C. , Parker, A.L., McVey, J.H. and Baker, A.H. (2011) A cluster of basic amino acids in the factor X serine protease mediate surface attachment of adenovirus/FX complexes. Journal of Virology, 85(20), pp. 10914-10919. (doi: 10.1128/JVI.05382-11)

White, K., Loughlin, L., Maqbool, Z., Nilsen, M., McClure, J. , Dempsie, Y., Baker, A. H. and MacLean, M. R. (2011) Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH. Physiological Genomics, 43(8), pp. 417-437. (doi: 10.1152/physiolgenomics.00249.2010)

Caporali, A. et al. (2011) Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation, 123(3), pp. 282-291. (doi: 10.1161/CIRCULATIONAHA.110.952325)

Kane, N. M., Xiao, Q., Baker, A. H., Luo, Z., Xu, Q. and Emanueli, C. (2011) Pluripotent stem cell differentiation into vascular cells: a novel technology with promises for vascular re(generation). Pharmacology and Therapeutics, 129(1), pp. 29-49. (doi: 10.1016/j.pharmthera.2010.10.004)

Baker, A.H. (2011) MicroRNA 21 "Shapes" Vascular Smooth Muscle Behavior Through Regulating Tropomyosin 1. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(9), pp. 1941-1942. (doi: 10.1161/ATVBAHA.111.231985)

Denby, L. et al. (2011) miR-21 and miR-214 are consistently modulated during renal injury in rodent models. American Journal of Pathology, 179(2), pp. 661-672. (doi: 10.1016/j.ajpath.2011.04.021)

George, S. J., Wan, S., Hu, J., McDonald, R.A., Johnson, J. L. and Baker, A.H. (2011) Sustained reduction of vein graft neointima formation by ex vivo TIMP-3 gene therapy. Circulation, 124(11_sup), S135-S142. (doi: 10.1161/CIRCULATIONAHA.110.012732)

Burton, P. et al. (2010) Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells. Biochemical Journal, 432(3), pp. 575-584. (doi: 10.1042/BJ20100726)

Kane, N. M. et al. (2010) Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors. Molecular Therapy, 18(12), pp. 2139-2145. (doi: 10.1038/mt.2010.231)

Greig, J.A., Shirley, R., Graham, D. , Denby, L., Dominiczak, A.F. , Work, L.M. and Baker, A. (2010) Vascular-targeting anti-oxidant therapy in a model of hypertension and stroke. Journal of Cardiovascular Pharmacology, 56(6), pp. 642-650. (doi: 10.1097/FJC.0b013e3181f8f19f)

Othman, M. et al. (2010) Functional characterization of a 13-bp deletion (c.-1522_-1510del13) in the promoter of the von Willebrand factor gene in type 1 von Willebrand disease. Blood, 116(18), pp. 3645-3652. (doi: 10.1182/blood-2009-12-261131)

Alba, R. et al. (2010) Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors. Blood, 14(116), pp. 2656-2664. (doi: 10.1182/blood-2009-12-260026)

Burton, P. et al. (2010) Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells. Biochemical Society Transactions, 38(4), pp. 1058-1061. (doi: 10.1042/BST0381058)

Kane, N. M., Meloni, M., Spencer, H. L., Craig, M. A., Strehl, R., Milligan, G., Houslay, M. D., Mountford, J. C., Emanueli, C. and Baker, A. H. (2010) Derivation of endothelial cells from human embryonic stem cells by directed differentiation: analysis of microRNA and angiogenesis in vitro and in vivo. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(7), pp. 1389-1397. (doi: 10.1161/ATVBAHA.110.204800)

Craig, M. A., McBride, M. W. , Smith, G., George, S. and Baker, A. (2010) Dysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat. Journal of Molecular and Cellular Cardiology, 48(6), pp. 1121-1128. (doi: 10.1016/j.yjmcc.2010.01.017)

Caruso, P. et al. (2010) Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(4), pp. 716-723. (doi: 10.1161/ATVBAHA.109.202028)

Shin, S.Y., Kim, J.H., Baker, A.H., Lim, Y. and Lee, Y.H. (2010) Transcription factor Egr-1 is essential for maximal matrix metalloproteinase-9 transcription by tumor necrosis factor α. Molecular Cancer Research, 8(4), pp. 507-519. (doi: 10.1158/1541-7786.MCR-09-0454) (PMID:20332214)

Balestrieri, M. L. et al. (2010) Therapeutic angiogenesis in diabetic apolipoprotein E-deficient mice using bone marrow cells, functional hemangioblasts and metabolic intervention. Atherosclerosis, 209(2), pp. 403-414. (doi: 10.1016/j.atherosclerosis.2009.10.022)

Bradshaw, A.C. , Parker, A.L., Duffy, M.R., Coughlan, L., van Rooijen, N., Kahari, V.M., Nicklin, S.A. and Baker, A.H. (2010) Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X. PLoS Pathogens, 6(10), e1001142. (doi: 10.1371/journal.ppat.1001142)

Coughlan, L., Alba, R., Parker, A.L., Bradshaw, A.C. , Mcneish, I.A. , Nicklin, S. and Baker, A. (2010) Tropism-modification strategies for targeted gene delivery using adenoviral vectors. Viruses, 2(10), pp. 2290-2355. (doi: 10.3390/v2102290) (PMID:21994621) (PMCID:PMC3185574)

Kallio, J.P., Hopkins-Donaldson, S., Baker, A.H. and Kähäri, V.M. (2010) TIMP-3 promotes apoptosis in nonadherent small cell lung carcinoma cells lacking functional death receptor pathway. International Journal of Cancer, 128(4), pp. 991-996. (doi: 10.1002/ijc.25404)

Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6(10), e1001177. (doi: 10.1371/journal.pgen.1001177)

Alba, R. et al. (2009) Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer. Blood, 114(5), pp. 965-971. (doi: 10.1182/blood-2009-03-208835)

Terashima, T., Oka, K., Kritz, A. B., Kojima, H., Baker, A. H. and Chan, L. (2009) DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice. Journal of Clinical Investigation, 119(7), pp. 2100-2112. (doi: 10.1172/JCI39038)

Nicol, C. G., Denby, L., Lopez-Franco, O., Masson, R., Halliday, C. A., Nicklin, S. A., Kritz, A., Work, L. M. and Baker, A. H. (2009) Use of in vivo phage display to engineer novel adenoviruses for targeted delivery to the cardiac vasculature. FEBS Letters, 583(12), pp. 2100-2107. (doi: 10.1016/j.febslet.2009.05.037)

Diaconu, I. et al. (2009) Serotype chimeric and fiber-mutated adenovirus Ad5/19p-HIT for targeting renal cancer and untargeting the liver. Human Gene Therapy, 20(6), pp. 611-620. (doi: 10.1089/hum.2008.108)

Liu, Y., Wang, H.J., Yumul, R., Gao, W.T., Gambotto, A., Morita, T., Baker, A.H., Shayakhmetov, D. and Lieber, A. (2009) Transduction of liver metastases after intravenous injection of Ad5/35 or Ad35 vectors with and without factor X-binding protein pretreatment. Human Gene Therapy, 20(6), pp. 621-629. (doi: 10.1089/hum.2008.142)

Parker, A.L., Waddington, S.N., Buckley, S.M.K., Custers, J., Havenga, M.J.E., van Rooijen, N., Goudsmit, J., Mcvey, J.H., Nicklin, S.A. and Baker, A.H. (2009) Effect of neutralizing sera on factor X-mediated adenovirus serotype 5 gene transfer. Journal of Virology, 83(1), pp. 479-483. (doi: 10.1128/JVI.01878-08)

Greig, J.A. et al. (2009) Influence of Coagulation Factor X on In Vitro and In Vivo Gene Delivery by Adenovirus (Ad) 5, Ad35, and Chimeric Ad5/Ad35 Vectors. Molecular Therapy, 17(10), pp. 1683-1691. (doi: 10.1038/mt.2009.152)

Lenaerts, L., Mcvey, J., Baker, A., Denby, L., Nicklin, S., Verbeken, E. and Naesens, L. (2009) Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting. Journal of Gene Medicine, 11(2), pp. 119-127. (doi: 10.1002/jgm.1283)

Masson, R. et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53(4), pp. 694-700. (doi: 10.1161/HYPERTENSIONAHA.108.122333)

Parker, A.L., Nicklin, S.A. and Baker, A.H. (2008) Interactions of adenovirus vectors with blood: implications for intravascular gene therapy applications. Current Opinion in Molecular Therapeutics, 10(5), pp. 439-448.

Graham, T., McIntosh, J., Work, L. , Nathwani, A. and Baker, A. (2008) Performance of AAV8 vectors expressing human factor IX from a hepatic-selective promoter following intravenous injection into rats. Genetic Vaccines and Therapy, 6(1), p. 9. (doi: 10.1186/1479-0556-6-9)

White, K. et al. (2008) Engineering adeno-associated virus 2 vectors for targeted gene delivery to atherosclerotic lesions. Gene Therapy, 15(6), pp. 443-451. (doi: 10.1038/sj.gt.3303077)

Waddington, S. et al. (2008) Adenovirus serotype 5 hexon mediates liver gene transfer. Cell, 132(3), pp. 397-409. (doi: 10.1016/j.cell.2008.01.016)

Miller, A. M., Xu, D., Asquith, D. L., Denby, L., Li, Y., Sattar, N. , Baker, A. H., McInnes, I. B. and Liew, F. Y. (2008) IL-33 reduces the development of atherosclerosis. Journal of Experimental Medicine, 205(2), pp. 339-346. (doi: 10.1084/jem.20071868) (PMID:18268038) (PMCID:PMC2271006)

Baker, A. (2008) Interaction of Ad5 with blood coagulation factor X mediates liver gene transfer. Human Gene Therapy, 19(10), pp. 1072-1073.

Benest, A.V., Stone, O.A., Miller, W.H., Glover, C.P., Uney, J.B., Baker, A.H., Harper, S.J. and Bates, D.O. (2008) Arteriolar genesis and angiogenesis induced by endothelial nitric oxide synthase overexpression results in a mature vasculature. Arteriosclerosis, Thrombosis, and Vascular Biology, 28(8), pp. 1462-1468. (doi: 10.1161/ATVBAHA.108.169375)

Buckley, S. et al. (2008) Luciferin Detection After Intranasal Vector Delivery Is Improved by Intranasal Rather Than Intraperitoneal Luciferin Administration. Human Gene Therapy, 19(10), pp. 1050-1056.

Flores-Munoz, M., Baker, A. and Nicklin, S. (2008) Development of a gene transfer vector expressing angiotensin 1-7 and assessment of its effects on cardiac hypertrophy. Journal of Human Hypertension, 22(10), p. 723.

Kane, N.M., McRae, S., Denning, C. and Baker, A.H. (2008) Viral and non-viral gene delivery and its role in pluripotent stem cell engineering. Drug Discovery Today: Technologies, 5(4), e107-e115. (doi: 10.1016/j.ddtec.2008.10.002)

Kritz Wilson, A.B., Yu, J., Wright, P.L., Wan, S., George, S.J., Halliday, C., Kang, N., Sessa, W.C. and Baker, A.H. (2008) In Vivo Modulation of Nogo-B Attenuates Neointima Formation. Molecular Therapy, 16(11), pp. 1798-1804. (doi: 10.1038/mt.2008.188)

Nicklin, S. and Baker, A. (2008) Efficient Vascular Endothelial Gene Transfer Following Intravenous Adenovirus Delivery. Molecular Therapy, 16(12), pp. 1904-1905. (doi: 10.1038/mt.2008.226)

Parker, A., Parker, A., Mcvey, J., Waddington, S., Buckley, S., Francischetti, I., Monteiro, R., Nicklin, S. and Baker, A. (2008) An exosite within the human FX serine protease domain mediates cell transduction of AD5: FX complexes. Human Gene Therapy, 19(4), p. 34.

Wang, H. et al. (2008) In Vitro and In Vivo Properties of Adenovirus Vectors with Increased Affinity to CD46. Journal of Virology, 82(21), pp. 10567-10579.

Waddington, S.N., Parker, A.L., Havenga, M., Nicklin, S.A., Buckley, S.M., McVey, J.H. and Baker, A.H. (2007) Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: Fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5. Journal of Virology, 81(17), pp. 9568-9571. (doi: 10.1128/JVI.00663-07)

Kritz, A. B., Nicol, C. G., Dishart, K. L., Nelson, R., Holbeck, S., Von Seggern, D. J., Work, L. M., Mcvey, J. H., Nicklin, S. A. and Baker, A. H. (2007) Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop. Molecular Therapy, 15, pp. 741-749. (doi: 10.1038/sj.mt.6300094)

Baker, A.H. et al. (2007) Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia. Proceedings of the National Academy of Sciences of the United States of America, 104, pp. 3597-3602. (doi: 10.1073/pnas.0611112104)

Baker, A., Mcvey, J., Waddington, S., Di Paolo, N. and Shayakhmetov, D. (2007) The influence of blood on in vivo adenovirus bio-distribution and transduction. Molecular Therapy, 15(8), pp. 1410-1416. (doi: 10.1038/sj.mt.6300206)

Denby, L., Work, L.M., Von Seggern, D.J., Wu, E., Mcvey, J.H., Nicklin, S.A. and Baker, A.H. (2007) Development of renal-targeted vectors through combined in vivo phage display and capsid engineering of adenoviral fibers from serotype 19p. Molecular Therapy, 15(9), pp. 1647-1654. (doi: 10.1038/sj.mt.6300214)

Maffia, P. , Zinselmeyer, B.H., Ialenti, A., Kennedy, S. , Baker, A.H., McInnes, I., Brewer, J.M. and Garside, P. (2007) Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery. Circulation, 115(11), E326-E328. (doi: 10.1161/CIRCULATIONAHA.106.658492) (PMID:17372180)

Magnoni, S., Baker, A., Thomson, S., Jordan, G., George, S., Mccoll, B., McCulloch, J. and Horsburgh, K. (2007) Neuroprotective effect of adenoviral-mediated gene transfer of TIMP-1 and-2 in ischemic brain injury. Gene Therapy, 14, pp. 621-625. (doi: 10.1038/sj.gt.3302894)

Mccoll, B., McGregor, A., Wong, A., Harris, J., Amalfitano, A., Magnoni, S., Baker, A., Dickson, G. and Horsburgh, K. (2007) APOE epsilon 3 gene transfer attenuates brain damage after experimental stroke. Journal of Cerebral Blood Flow and Metabolism, 27, pp. 477-487. (doi: 10.1038/sj.jcbfm.9600361)

Parker, A., Mcvey, J., Doctor, J., Lopez-Franco, O., Waddington, S., Havenga, M., Nicklin, S. and Baker, A. (2007) Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D. Journal of Virology, 81, pp. 3627-3631. (doi: 10.1128/JVI.02786-06)

Sithu, S., English, W., Olson, P., Krubasik, D., Baker, A., Murphy, G. and D'Souza, S. (2007) Membrane-type 1-matrix metalloproteinase regulates intracellular adhesion molecule-1 (ICAM-1)-mediated monocyte transmigration. Journal of Biological Chemistry, 282, pp. 25010-25019. (doi: 10.1074/jbc.M611273200)

Smyth, A., Reid, H., Baker, A. and McGlynn, H. (2007) Modifications of the radiosensitivity of a renal cancer cell line as a consequence of stable TIMP-1 overexpression. International Journal of Radiation Biology, 83, pp. 13-25. (doi: 10.1080/09553000600983136)

Toriseva, M., Ala-aho, R., Karvinen, J., Baker, A., Marjomaki, V., Heino, J. and Kahari, V. (2007) Collagenase-3 (MMP-13) enhances remodeling of three-dimensional collagen and promotes survival of human skin fibroblasts. Journal of Investigative Dermatology, 127, pp. 49-59.

Van Roy, M., Wielockx, B., Baker, A. and Libert, C. (2007) The use of tissue inhibitors of matrix metalloproteinases to increase the efficacy of a tumor necrosis factor/interferon gamma antitumor therapy. Cancer Gene Therapy, 14, pp. 372-379. (doi: 10.1038/sj.cgt.7701020)

White, K., Nicklin, S. and Baker, A. (2007) Novel vectors for in vivo gene delivery to vascular tissue. Expert Opinion on Biological Therapy, 7(6), pp. 809-821. (doi: 10.1517/14712598.7.6.809)

Yoshida, S. et al. (2007) Metalloproteinase inhibition has differential effects on alloimmunity, autoimmunity, and histopathology in the transplanted lung. Transplantation, 83(6), pp. 799-808. (doi: 10.1097/01.tp.0000258600.05531.5d)

Parker, A.L. et al. (2006) Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes in vitro and in vivo. Blood, 108(8), pp. 2554-2561. (doi: 10.1182/blood-2006-04-008532)

Finan, K. M., Hodge, G., Reynolds, A. M., Hodge, S., Holmes, M. D., Baker, A. H. and Reynolds, P. N. (2006) In vitro susceptibility to the pro-apoptotic effects of TIMP-3 gene delivery translates to greater in vivo efficacy versus gene delivery for TIMPs-1 or-2. Lung Cancer, 53, pp. 273-284. (doi: 10.1016/j.lungcan.2006.06.006) (PMID:16860902)

Perabo, L. et al. (2006) Heparan sulfate proteoglycan binding properties of adeno-associated virus retargeting mutants and consequences for their in vivo tropism. Journal of Virology, 80(14), pp. 7265-7269. (doi: 10.1128/JVI.00076-06)

Baker, A., Yim, A. and Wan, S. (2006) Opportunities for gene therapy in preventing vein graft failure after coronary artery bypass surgery. Diabetes, Obesity and Metabolism, 8(2), pp. 119-124. (doi: 10.1111/j.1463-1326.2005.00494.x) (PMID:16448515)

de Nooijer, R., Verkleij, C.J.N., der Thusen, J.H., Jukema, J.W., van der Wall, E.E., van Berkel, T.J.C., Baker, A.H. and Biessen, E.A.L. (2006) Lesional overexpression of matrix metalloproteinase-9 promotes intraplaque hemorrhage in advanced lesions but not at earlier stages of atherogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology, 26, pp. 340-346. (doi: 10.1161/01.ATV.0000197795.56960.64)

George, S., Channon, K. and Baker, A. (2006) Gene therapy and coronary artery bypass grafting: Current perspectives. Current Opinion in Molecular Therapeutics, 8, pp. 288-294.

Heymans, S. et al. (2006) Inhibition of urokinase-type plasminogen activator or matrix metalloproteinases prevents cardiac injury and dysfunction during viral myocarditis. Circulation, 114, pp. 565-573. (doi: 10.1161/CIRCULATIONAHA.105.591032)

Johnson, J., Baker, A., Oka, K., Chan, L., Newby, A., Jackson, C. and George, S. (2006) Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2 - Involvement of macrophage migration and apoptosis. Circulation, 113, pp. 2435-2444. (doi: 10.1161/CIRCULATIONAHA.106.613281)

Kim, M., Bodenstine, T., Sumerel, L., Rivera, A., Baker, A. and Douglas, J. (2006) Tissue inhibitor of metalloproteinases-2 improves antitumor efficacy of a replicating adenovirus in vivo. Cancer Biology and Therapy, 5, pp. 1647-1653.

Parker, A. et al. (2006) Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes. Blood, 108, pp. 2554-2561. (doi: 10.1182/blood-2006-04-008532)

Work, L.M. et al. (2006) Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses. Molecular Therapy, 13(4), pp. 683-693. (doi: 10.1016/j.ymthe.2005.11.013)

Akowuah, E. et al. (2005) Ultrasound-mediated delivery of TIMP-3 plasmid DNA into saphenous vein leads to increased lumen size in a porcine interposition graft model. Gene Therapy, 12, pp. 1154-1157. (doi: 10.1038/sj.gt.3302498)

Baker, A., Kritz, A., Work, L., Nicklin, S. and Nicklin, A. (2005) Cell-selective viral gene delivery vectors for the vasculature. Experimental Physiology, 90(1), pp. 27-31. (doi: 10.1113/expphysiol.2004.028126)

Denby, L., Nicklin, S.A. and Baker, A.H. (2005) Adeno-associated virus (AAV)-7 and-8 poorly transduce vascular endothelial cells and are sensitive to proteasomal degradation. Gene Therapy, 12, pp. 1534-1538. (doi: 10.1038/sj.gt.3302564)

Heymans, S., Lupu, F., Terclavers, S., Vanwetswinkel, B., Herbert, J., Baker, A., Collen, D., Carmeliet, P. and Moons, L. (2005) Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice. American Journal of Pathology, 166(1), pp. 15-25.

Lovelock, J.D., Baker, A.H., Gao, F., Dong, J.F., Bergeron, A.L., McPheat, W., Sivasubramanian, N. and Mann, D.L. (2005) Heterogeneous effects of tissue inhibitors of matrix metalloproteinases on cardiac fibroblasts. American Journal of Physiology: Heart and Circulatory Physiology, 288, H461-H468. (doi: 10.1152/ajpheart.00402.2004)

Miller, W. , Brosnan, M.J., Graham, D., Nicol, C.G., Morecroft, I., Channon, K.M., Danilov, S.M., Reynolds, P.N., Baker, A.H. and Dominiczak, A.F. (2005) Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats. Molecular Therapy, 12(2), pp. 321-327. (doi: 10.1016/j.ymthe.2005.02.025)

Nicklin, S., Wu, E., Nemerow, G. and Baker, A. (2005) The influence of adenovirus fiber structure and function on vector development for gene therapy. Molecular Therapy, 12(3), pp. 384-393. (doi: 10.1016/j.ymthe.2005.05.008)

Parker, A., Fisher, K., Oupicky, D., Read, M., Nicklin, S., Baker, A. and Seymour, L. (2005) Enhanced gene transfer activity of peptide-targeted gene-delivery vectors. Journal of Drug Targeting, 13, pp. 39-51. (doi: 10.1080/10611860400020449)

White, S., Simmonds, R., Lane, D. and Baker, A. (2005) Efficient isolation of peptide ligands for the endothelial cell protein C receptor (EPCR) using candidate receptor phage display biopanning. Peptides, 26, pp. 1264-1269. (doi: 10.1016/j.peptides.2005.01.015)

Work, L.M. , Reynolds, P. N. and Baker, A. H. (2004) Improved gene delivery to human saphenous vein cells and tissue using a peptide-modified adenoviral vector. Genetic Vaccines and Therapy, 2(1), p. 14. (doi: 10.1186/1479-0556-2-14)

Baker, A. (2004) Designing gene delivery vectors for cardiovascular gene therapy. Progress in Biophysics and Molecular Biology, 84, pp. 279-299. (doi: 10.1016/j.pbiomolbio.2003.11.006)

Denby, L., Work, L.M., Graham, D. , Hsu, C., Von Seggern, D.J., Nicklin, S.A. and Baker, A.H. (2004) Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo. Human Gene Therapy, 15(11), pp. 1054-1064.

Elezkurtaj, S., Kopitz, C., Baker, A., Perez-Canto, A., Arlt, M., Khokha, R., Gansbacher, B., Anton, M., Brand, K. and Kruger, A. (2004) Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis. Journal of Gene Medicine, 6, pp. 1228-1237. (doi: 10.1002/jgm.637)

Magnoni, S., Baker, A., George, S., Duncan, W., Kerr, L., McCulloch, J. and Horsburgh, K. (2004) Differential alterations in the expression and activity of matrix metalloproteinases 2 and 9 after transient cerebral ischemia in mice. Neurobiology of Disease, 17, pp. 188-197. (doi: 10.1016/j.nbd.2004.07.020)

Nicklin, S., White, S., Nicol, C., Von Seggern, D. and Baker, A. (2004) In vitro and in vivo characterisation of endothelial cell selective adenoviral vectors. Journal of Gene Medicine, 6, pp. 300-308. (doi: 10.1002/jgm.526)

Nicol, C., Graham, D., Miller, W., White, S., Smith, T., Nicklin, S., Stevenson, S. and Baker, A. (2004) Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats. Molecular Therapy, 10(2), pp. 344-354. (doi: 10.1016/j.ymthe.2004.05.020)

Papadakis, E., Nicklin, S., Baker, A. and White, S. (2004) Promoters and control elements: Designing expression cassettes for gene therapy. Current Gene Therapy, 4, pp. 89-113.

Wan, S., George, S., Nicklin, S., Yim, A. and Baker, A. (2004) Overexpression of p53 increases lumen size and blocks neointima formation in porcine interposition vein grafts. Molecular Therapy, 9(5), pp. 689-698. (doi: 10.1016/j.ymthe.2004.02.005)

White, S., Nicklin, S., Buning, H., Brosnan, M., Leike, K., Papadakis, E., Hallek, M. and Baker, A. (2004) Targeted gene delivery to vascular tissue in vivo by tropism-modified adeno-associated virus vectors. Circulation, 109, pp. 513-519. (doi: 10.1161/01.CIR.0000109697.68832.5D)

Work, L., Nicklin, S., Brain, N., Dishart, K., Von Seggern, D., Hallek, M., Buning, H. and Baker, A. (2004) Development of efficient viral vectors selective for vascular smooth muscle cells. Molecular Therapy, 9(2), pp. 198-208. (doi: 10.1016/j.ymthe.2003.11.006)

Work, L., Ritchie, N., Nicklin, S., Reynolds, P. and Baker, A. (2004) Dual targeting of gene delivery by genetic modification of adenovirus serotype 5 fibers and cell-selective transcriptional control. Gene Therapy, 11, pp. 1296-1300. (doi: 10.1038/sj.gt.3302292)

Dishart, K.L., Work, L.M. , Denby, L. and Baker, A.H. (2003) Gene therapy for cardiovascular disease. Journal of Biomedicine and Biotechnology, 2003(2), pp. 138-148. (doi: 10.1155/S1110724303209086)

Ahonen, M., Poukkula, M., Baker, A., Kashiwagi, M., Nagase, H., Eriksson, J. and Kahari, V. (2003) Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors. Oncogene, 22, pp. 2121-2134. (doi: 10.1038/sj.onc.1206292)

Baker, A. (2003) Targeting AAV vectors. Molecular Therapy, 7(4), pp. 433-434. (doi: 10.1016/S1525-0016(03)00072-8)

Buning, H., Nicklin, S., Perabo, L., Hallek, M. and Baker, A. (2003) AAV-based gene transfer. Current Opinion in Molecular Therapeutics, 5, pp. 367-375.

de Nigris, F., Lerman, A., Ignarro, L., Williams-Ignarro, S., Sica, V., Baker, A., Lerman, L., Geng, Y. and Napoli, C. (2003) Oxidation-sensitive mechanisms, vascular apoptosis and atherosclerosis. Trends in Molecular Medicine, 9, pp. 351-359. (doi: 10.1016/S1471-4914(03)00139-4)

Dishart, K.L. et al. (2003) Third-generation lentivirus vectors efficiently transduce and phenotypically modify vascular cells: implications for gene therapy. Journal of Molecular and Cellular Cardiology, 35(7), pp. 739-748. (doi: 10.1016/S0022-2828(03)00136-6)

Gruss, C. et al. (2003) Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice. Journal of Investigative Dermatology, 120, pp. 683-692.

Lambert, V. et al. (2003) MMP-2 and MMP-9 synergize in promoting choroidal neovascularization. FASEB Journal, 17(15), pp. 2290-2292. (doi: 10.1096/fj.03-0113fje)

MacKenzie, C., Paul, A., Wilson, S., de Martin, R., Baker, A. and Plevin, R. (2003) Enhancement of lipopolysaccharide-stimulated JNK activity in rat aortic smooth muscle cells by pharmacological and adenovirusmediated inhibition of inhibitory kappa B kinase signalling. British Journal of Pharmacology, 139, pp. 1041-1049. (doi: 10.1038/sj.bjp.0705330)

Nicklin, S., Dishart, K., Buening, H., Reynolds, P., Hallek, M., Nemerow, G., Von Seggern, D. and Baker, A. (2003) Transductional and transcriptional targeting of cancer cells using genetically engineered viral vectors. Cancer Letters, 201, pp. 165-173. (doi: 10.1016/j.canlet.2003.07.003)

Qi, J., Ebrahem, Q., Moore, N., Murphy, G., Claesson-Welsh, L., Bond, M., Baker, A. and Anand-Apte, B. (2003) A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2. Nature Medicine, 9, pp. 407-415. (doi: 10.1038/nm846)

Tan, H., Heywood, D., Ralph, G., Bienemann, A., Baker, A. and Uney, J. (2003) Tissue inhibitor of metalloproteinase 1 inhibits excitotoxic cell death in neurons. Molecular and Cellular Neuroscience, 22, pp. 98-106. (doi: 10.1016/S1044-7431(02)00024-6)

Vieillard-Baron, A., Frisdal, E., Raffestin, B., Baker, A., Eddahibi, S., Adnot, S. and D'Ortho, M. (2003) Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer limits monocrotaline-induced pulmonary vascular remodeling in rats. Human Gene Therapy, 14, pp. 861-869.

Work, L., Nicklin, S. and Baker, A. (2003) Targeting Gene Therapy Vectors to the Vascular Endothelium. Current Atherosclerosis Reports, 5(3), pp. 163-170.

Majid, M. A., Smith, V. A., Easty, D. L., Baker, A. H. and Newby, A. C. (2002) Sorsby's fundus dystrophy mutant tissue inhibitors of metalloproteinase-3 induce apoptosis of retinal pigment epithelial and MCF-7 cells. FEBS Letters, 529(2-3), pp. 281-285. (doi: 10.1016/S0014-5793(02)03359-8)

Van de Louw, A., Jean, D., Frisdal, E., Cerf, C., D'Ortho, M.-P., Baker, A. H., Lafuma, C., Duvaldestin, P., Harf, A. and Delclaux, C. (2002) Neutrophil proteinases in hydrochloric acid- and endotoxin-induced acute lung injury: Evaluation of interstitial protease activity by in situ zymography. Laboratory Investigation, 82(2), pp. 133-145. (doi: 10.1038/labinvest.3780406) (PMID:11850527)

Ahonen, M., Ala-aho, R., Baker, A., George, S., Grenman, R., Saarialho-Kere, U. and Kahari, V. (2002) Antitumor activity and bystander effect of adenovirally delivered tissue inhibitor of metalloproteinases-3. Molecular Therapy, 5(6), pp. 705-715. (doi: 10.1006/mthe.2002.0606)

Ala-aho, R., Johansson, N., Baker, A. and Kahari, V. (2002) Expression of collagenase-3 (MMP-13) enhances invasion of human fibrosarcoma HT-1080 cells. International Journal of Cancer, 97(3), pp. 283-289. (doi: 10.1002/ijc.1619)

Bainbridge, J., Mistry, A., De Alwis, M., Paleolog, E., Baker, A., Thrasher, A. and Ali, R. (2002) Inhibition of retinal neovascularisation by gene transfer of soluble VEGF receptor sFlt-1. Gene Therapy, 9, pp. 320-326. (doi: 10.1038/sj/gt/3301680)

Baker, A. (2002) Development and use of gene transfer for treatment of cardiovascular disease. Journal of Cardiac Surgery, 17(6), pp. 543-548. (doi: 10.1046/j.1540-8191.2002.01011.x)

Baker, A. (2002) Gene therapy for bypass graft failure and restenosis. Pathophysiology of Haemostasis and Thrombosis, 32, pp. 389-391.

Baker, A., Edwards, D. and Murphy, G. (2002) Metalloproteinase inhibitors: biological actions and therapeutic opportunities. Journal of Cell Science, 115, pp. 3719-3727. (doi: 10.1242/jcs.00063)

Bauerschmitz, G., Nettelbeck, D., Kanerva, A., Baker, A., Hemminki, A., Reynolds, P. and Curiel, D. (2002) The flt-1 promoter for transcriptional targeting of teratocarcinoma. Cancer Research, 62, pp. 1271-1274.

Bond, M., Murphy, G., Bennett, M., Newby, A. and Baker, A. (2002) Tissue inhibitor of metalloproteinase-3 induces a Fas-associated death domain-dependent type II apoptotic pathway. Journal of Biological Chemistry, 277, pp. 13787-13795. (doi: 10.1074/jbc.M111507200)

Fennell, J., Brosnan, M., Frater, A., Hamilton, C., Alexander, M., Nicklin, S., Heistad, D., Baker, A. and Dominiczak, A. (2002) Adenovirus-mediated overexpression of extracellular superoxide dismutase improves endothelial dysfunction in a rat model of hypertension. Gene Therapy, 9(2), pp. 110-117. (doi: 10.1038/sj.gt.3301633)

Majid, M., Smith, V., Easty, D., Baker, A. and Newby, A. (2002) Adenovirus mediated gene delivery of tissue inhibitor of metalloproteinases-3 induces death in retinal pigment epithelial cells. British Journal of Ophthalmology, 86(1), pp. 97-101.

Nicklin, S. and Baker, A. (2002) Tropism-Modified Adenoviral and Adeno-Associated Viral Vectors for Gene Therapy. Current Gene Therapy, 2(3), pp. 273-293.

Turunen, M. et al. (2002) Peptide-retargeted adenovirus encoding a tissue inhibitor of metalloproteinase-1 decreases restenosis after intravascular gene transfer. Molecular Therapy, 6(3), pp. 306-312. (doi: 10.1006/mthe.2002.0668)

Apparailly, F., Noel, D., Millet, V., Baker, A., Lisignoli, G., Jacquet, C., Kaiser, M., Sany, J. and Jorgensen, C. (2001) Paradoxical effects of tissue inhibitor of metalloproteinases 1 gene transfer in collagen-induced arthritis. Arthritis and Rheumatism, 44(6), pp. 1444-1454. (doi: 10.1002/1529-0131(200106)44:6<1444::AID-ART240>3.0.CO;2-Q)

Bond, M., Chase, A., Baker, A. and Newby, A. (2001) Inhibition of transcription factor NF-kappa B reduces matrix metalloproteinase-1,-3 and-9 production by vascular smooth muscle cells. Cardiovascular Research, 50, pp. 556-565. (doi: 10.1016/S0008-6363(01)00220-6)

George, S., Angelini, G., Capogrossi, M. and Baker, A. (2001) Wild-type p53 gene transfer inhibits neointima formation in human saphenous vein by modulation of smooth muscle cell migration and induction of apoptosis. Gene Therapy, 8(9), pp. 668-676. (doi: 10.1038/sj.gt.3301431)

Hu, Y.H., Baker, A.H., Zou, Y.P., Newby, A.C. and Xu, Q.B. (2001) Local gene transfer of tissue inhibitor of metalloproteinase-2 influences vein graft remodeling in a mouse model. Arteriosclerosis, Thrombosis, and Vascular Biology, 21(8), pp. 1275-1280. (doi: 10.1161/hq0801.093658)

Nicklin, S., Buening, H., Dishart, K., De Alwis, M., Girod, A., Hacker, U., Thrasher, A., Ali, R., Hallek, M. and Baker, A. (2001) Efficient and selective AAV2-mediated gene transfer directed to human vascular endothelial cells. Molecular Therapy, 4(2), pp. 174-181. (doi: 10.1006/mthe.2001.0424)

Nicklin, S., Reynolds, P., Brosnan, M., White, S., Curiel, D., Dominiczak, A. and Baker, A. (2001) Analysis of cell-specific promoters for viral gene therapy targeted at the vascular endothelium. Hypertension, 38(1), pp. 65-70. (doi: 10.1161/01.HYP.38.1.65)

Nicklin, S., Von Seggern, D., Work, L., Pek, D., Dominiczak, A., Nemerow, G. and Baker, A. (2001) Ablating adenovirus type 5 fiber-CAR binding and HI loop insertion of the SIGYPLP peptide generate an endothelial cell-selective adenovirus. Molecular Therapy, 4(6), pp. 534-542. (doi: 10.1006/mthe.2001.0489)

Reynolds, P., Nicklin, S., Kaliberova, L., Boatman, B., Grizzle, W., Balyasnikova, I., Baker, A., Danilov, S. and Curiel, D. (2001) Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo. Nature Biotechnology, 19, pp. 838-842.

White, S., Nicklin, S., Sawamura, T. and Baker, A. (2001) Identification of peptides that target the endothelial cell-specific LOX-1 receptor. Hypertension, 37, pp. 449-455.

Nicklin, S. A. , White, S. J., Watkins, S. J., Hawkins, R. E. and Baker, A. H. (2000) Selective targeting of gene transfer to vascular endothelial cells by use of peptides isolated by phage display. Circulation, 102(2), pp. 231-237. (doi: 10.1161/01.CIR.102.2.231) (PMID:10889136)

Bond, M., Murphy, G., Bennett, M., Amour, A., Knauper, V., Newby, A. and Baker, A. (2000) Localization of the death domain of tissue inhibitor of metalloproteinase-3 to the N terminus - Metalloproteinase inhibition is associated with proapoptotic activity. Journal of Biological Chemistry, 275(52), pp. 41358-41363. (doi: 10.1074/jbc.M007929200)

Book Sections

Ballantyne, M. D., Rayner, K. J., Stewart, D. J., Baker, A. H. and Schlosser, K. (2019) MicroRNA and LncRNA in the vascular system. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 149-158. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_14)

Deng, L., Baker, A. H. and Bradshaw, A. C. (2017) MicroRNA delivery strategies to the lung in a model of pulmonary hypertension. In: Ishikawa, K. (ed.) Cardiac Gene Therapy: Methods and Protocols. Series: Methods in molecular biology (1521). Humana Press: New York, NY, pp. 325-338. ISBN 9781493965861 (doi: 10.1007/978-1-4939-6588-5_23)

Parker, A. L., Bradshaw, A. C. , Alba, R., Nicklin, S. A. and Baker, A. H. (2013) Capsid modification strategies for detargeting adenoviral vectors. In: Chillon, M. and Bosch, A. (eds.) Adenovirus: Methods and Protocols [3rd.]. Series: Methods in molecular biology (1089). Humana Press, pp. 45-59. ISBN 9781627036788 (doi: 10.1007/978-1-62703-679-5_3)

Alba, R., Baker, A. H. and Nicklin, S. (2012) Vector systems for prenatal gene therapy: principles of adenovirus design and production. In: Coutelle, C. and Waddington, S. N. (eds.) Prenatal Gene Therapy: Concepts, Methods, and Protocols. Series: Methods and protocols (891). Humana Press: Totowa, NJ, pp. 55-84. ISBN 9781617798726 (doi: 10.1007/978-1-61779-873-3_4)

Nicklin, S. A. and Baker, A. H. (2010) Adenoviral vectors. In: Herzog, R. W. and Zolotukhin, S. (eds.) A Guide to Human Gene Therapy. World Scientific Publishing, pp. 21-36. ISBN 9789814280907 (doi: 10.1142/9789814280914_0002)

Masson, R., Nicklin, S. A. and Baker, A. H. (2009) Gene delivery to cardiovascular tissue. In: Abraham, D., Handler, C., Dashwood, M. and Coghlan, G. (eds.) Advances in Vascular Medicine. Springer London, pp. 25-54. ISBN 9781848826366 (doi: 10.1007/978-1-84882-637-3_2)

Miller, W.H. , Nicklin, S.A. , Baker, A.H. and Dominiczak, A. (2005) Gene transfer and cardiovascular system. In: Raizada, M.K., Paton, J.F.R., Kasparov, S. and Katovich, M.J. (eds.) Cardiovascular Genomics. Series: Contemporary cardiology. Humana Press: Totowa, NJ, USA, pp. 175-196. ISBN 9781588294005

Work, L.M., Nicol, C.G., Denby, L. and Baker, A.H. (2004) In vivo biopanning: a methodological approach to identifying novel targeting ligands for delivery of biological agents to the vasculature. In: Fennell, J.P. and Baker, A.H. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular medicine (108). Humana Press: Totowa, NJ, USA, pp. 395-413. ISBN 9781588293237 (doi: 10.1385/1-59259-850-1:395)

Nicklin, S.A. and Baker, A.H. (2003) Development of targeted viral vectors for cardiovascular gene therapy. In: Setlow, J.K. (ed.) Genetic Engineering, Principles and Methods. Kluwer Academic: Dordrecht, The Netherlands, pp. 15-49. ISBN 9780306477768

Work, L. M. , Nicklin, S. A. , White, S. J. and Baker, A. H. (2002) Use of phage display to identify novel peptides for targeted gene therapy. In: Phillips, M. I. (ed.) Gene Therapy Methods. Series: Methods in enzymology (346). Academic Press: San Diego, California ; London, pp. 157-176. ISBN 9780121822477 (doi: 10.1016/S0076-6879(02)46055-7)

Nicklin, S. A. and Baker, A. H. (1999) Simple methods for preparing recombinant adenoviruses for high-efficiency transduction of vascular cells. In: Baker, A. H. (ed.) Vascular Disease: Molecular Biology and Gene Transfer Protocols. Series: Methods in molecular medicine (30). Humana Press: Totowa, NJ, pp. 271-284. ISBN 9780896037311 (doi: 10.1385/1-59259-247-3:271)