Dr Liane McGlynn
- SYMPHONY Project Manager (Cardiovascular & Metabolic Health)
telephone:
01413302740
email:
Liane.McGlynn@glasgow.ac.uk
BHF GCRC, Level 4 C443,, 126 University Place,, Glasgow,, G12 8TA
Publications
2023
Hill, C. et al. (2023) Differential methylation of telomere-related genes is associated with kidney disease in individuals with type 1 diabetes. Genes, 14(5), 1029. (doi: 10.3390/genes14051029) (PMID:37239390) (PMCID:PMC10217816)
2017
Lu, L., Johnman, C., McGlynn, L., Mackay, D. F. , Shiels, P. G. and Pell, J. P. (2017) Association between exposure to second-hand smoke and telomere length: cross-sectional study of 1303 non-smokers. International Journal of Epidemiology, 46(6), pp. 1978-1984. (doi: 10.1093/ije/dyx212) (PMID:29040594)
2015
Martin-Ruiz, C. M. et al. (2015) Is Southern blotting necessary to measure telomere length reproducibly? Authors’ Response to: Commentary: The reliability of telomere length measurements. International Journal of Epidemiology, 44(5), pp. 1686-1687. (doi: 10.1093/ije/dyv169) (PMID:26403813)
McGlynn, L. M., McCluney, S., Jamieson, N. B. , Thomson, J., MacDonald, A. I., Oien, K. , Dickson, E. J., Carter, C. R., McKay, C. J. and Shiels, P. G. (2015) SIRT3 & SIRT7: potential novel biomarkers for determining outcome in pancreatic cancer patients. PLoS ONE, 10(6), e0131344. (doi: 10.1371/journal.pone.0131344) (PMID:26121130) (PMCID:PMC4487247)
Martin-Ruiz, C. M. et al. (2015) Reproducibility of telomere length assessment: Authors’ Response to Damjan Krstajic and Ljubomir Buturovic. International Journal of Epidemiology, 44(5), pp. 1739-1741. (doi: 10.1093/ije/dyv170) (PMID:26403811)
2014
Lu, L., Johnman, C., McGlynn, L., Mackay, D.F. , Shiels, P. and Pell, J.P. (2014) Association between telomere length, inflammation and cardiovascular risk. European Journal of Public Health, 24(S2), p. 273. (doi: 10.1093/eurpub/cku165.080)
Martin-Ruiz, C. M. et al. (2014) Reproducibility of telomere length assessment: an international collaborative study. International Journal of Epidemiology, 44(5), pp. 1673-1683. (doi: 10.1093/ije/dyu191) (PMID:25239152) (PMCID:PMC4681105)
McGlynn, L.M. et al. (2014) SIRT2: Tumour suppressor or tumour promoter in operable breast cancer? European Journal of Cancer, 50(2), pp. 290-301. (doi: 10.1016/j.ejca.2013.10.005) (PMID:24183459)
2013
Rutherford, C. et al. (2013) Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1. Cell Death and Disease, 4(11), e927. (doi: 10.1038/cddis.2013.455)
McGlynn, L.M., Tovey, S., Bartlett, J.M.S., Doughty, J., Cooke, T.G. and Edwards, J. (2013) Interactions between MAP kinase and oestrogen receptor in human breast cancer. European Journal of Cancer, 49(6), pp. 1176-1186. (doi: 10.1016/j.ejca.2012.11.020)
McGlynn, L.M., Eller, K., MacDonald, A.I., MacIntyre, A., Russell, D., Koppelstaetter, C., Davies, R. and Shiels, P.G. (2013) Pathfinder cells provide a novel therapeutic intervention for acute kidney injury. Rejuvenation Research, 16(1), pp. 11-20. (doi: 10.1089/rej.2012.1350)
Gingell-Littlejohn, M., McGuinness, D., McGlynn, L.M., Kingsmore, D., Stevenson, K.S., Koppelstaetter, C., Clancy, M.J. and Shiels, P. (2013) Pre-transplant CDKN2A expression in kidney biopsies predicts renal function and is a future component of donor scoring criteria. PLoS ONE, 8(7), e68133. (doi: 10.1371/journal.pone.0068133) (PMID:23861858) (PMCID:PMC3701657)
Pathai, S. et al. (2013) Accelerated biological aging in HIV-infected individuals in South Africa: a case–control study. AIDS, 27(15), pp. 2375-2384. (doi: 10.1097/QAD.0b013e328363bf7f)
Roxburgh, C.S. , Richards, C.H., MacDonald, A.I., Powell, A.G., McGlynn, L.M., McMillan, D.C. , Horgan, P.G. , Edwards, J. and Shiels, P.G. (2013) The in situ local immune response, tumour senescence and proliferation in colorectal cancer. British Journal of Cancer, 109(8), pp. 2207-2216. (doi: 10.1038/bjc.2013.556)
2012
Sebastián, C. et al. (2012) The histone deacetylase SIRT6 is a novel tumor suppressor that controls cancer metabolism. Cell, 151(6), pp. 1185-1199. (doi: 10.1016/j.cell.2012.10.047) (PMID:23217706) (PMCID:PMC3526953)
Robertson, T., Batty, G.D., Der, G., Green, M.J., McGlynn, L.M., McIntyre, A., Shiels, P.G. and Benzeval, M. (2012) Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 study. PLoS ONE, 7(7), e41805. (doi: 10.1371/journal.pone.0041805) (PMID:22844525) (PMCID:PMC3402400)
McGuinness, D. et al. (2012) Socio-economic status is associated with epigenetic differences in the pSoBid cohort. International Journal of Epidemiology, 41(1), pp. 151-160. (doi: 10.1093/ije/dyr215)
Der, G., Batty, G.D., Benzeval, M., Deary, I.J., Green, M.J., McGlynn, L., McIntyre, A., Robertson, T. and Shiels, P.G. (2012) Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland? PLoS ONE, 7(9), e45166. (doi: 10.1371/journal.pone.0045166) (PMID:23028820) (PMCID:PMC3454419)
Gardani, M. , McMillan, T., Shiels, P. , McGlynn, L. and Stewart, E. (2012) An investigation of biological ageing processes following head injury. In: International Brain Injury Association's Ninth World Congress on Brain Injury, Edinburgh, UK, 21-25 Mar 2012, pp. 679-680. (doi: 10.3109/02699052.2012.660091)
2011
Maxwell, F., McGlynn, L.M., Muir, H.C., Talwar, D., Benzeval, M., Robertson, T., Roxburgh, C.S., McMillan, D. , Horgan, P.G. and Shiels, P. (2011) Telomere attrition and decreased Fetuin A levels indicate accelerated biological ageing and are implicated in the pathogenesis of colorectal cancer. Clinical Cancer Research, 17(17), pp. 5573-5581. (doi: 10.1158/1078-0432.CCR-10-3271)
Gingell-Littlejohn, M., McGuinness, D., McGlynn, L. M., Kingsmore, D., Clancy, M. J., Koppelstaetter, C., Mayer, G. and Shiels, P.G. (2011) Telomere Length Impacts on Allograft Function Post Kidney Transplant. In: 2011 American Transplant Conference, Phildadelphia, PA, USA, 30 Apr - 4 May 2011,
Shiels, P.G. et al. (2011) Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort. PLoS ONE, 6(7), e22521. (doi: 10.1371/journal.pone.0022521) (PMID:21818333) (PMCID:PMC3144896)
Stevenson, K. et al. (2011) Pancreatic derived pathfinder cells enable regeneration of critically damaged adult pancreatic tissue and completely reverse streptozotocin induced diabetes. Rejuvenation Research, 14(2), pp. 163-171. (doi: 10.1089/rej.2010.1099)
2010
Watson, C., Long, J.S., Orange, C., Tannahill, C.L., Mallon, E., McGlynn, L.M., Pyne, S., Pyne, N.J. and Edwards, J. (2010) High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. American Journal of Pathology, 177(5), pp. 2205-2215. (doi: 10.2353/ajpath.2010.100220)
2009
Stevenson, K.S., McGlynn, L.M., Hodge, M., McLinden, H., George, W.D., Davies, R.W. and Shiels, P.G. (2009) Isolation, characterization, and differentiation of Thy1.1-sorted pancreatic adult progenitor cell populations. Stem Cells and Development, 18(10), pp. 1389-1398. (doi: 10.1089/scd.2008.0301)
Stevenson, K.S., McGlynn, L.M. and Shiels, P.G. (2009) Stem cells: outstanding potential and outstanding questions. Scottish Medical Journal, 54(4), pp. 35-37. (doi: 10.1258/rsmsmj.54.4.35)
McGlynn, L.M., Kirkegaard, T., Edwards, J., Tovey, S., Cameron, D., Twelves, C., Bartlett, J.M.S. and Cooke, T.G. (2009) Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients. Clinical Cancer Research, 15(4), pp. 1487-1495. (doi: 10.1158/1078-0432.CCR-07-4967)
McGlynn, L.M., Stevenson, K., Lamb, K., Zino, S., Brown, M., Prina, A., Kingsmore, D. and Shiels, P.G. (2009) Cellular senescence in pre-transplant renal biopsies predicts postoperative organ function. Aging Cell, 8(1), pp. 45-51. (doi: 10.1111/j.1474-9726.2008.00447.x)
Brown, S.B.F., Mallon, E.A., Edwards, J., Campbell, F.M., McGlynn, L.M., Elsberger, B. and Cooke, T.G. (2009) Is the biology of breast cancer changing? A study of hormone receptor status 1984-1986 and 1996-1997. British Journal of Cancer, 100(5), pp. 807-810. (doi: 10.1038/sj.bjc.6604934)
2008
Maclntyre, A., Brouilette, S.W., Lamb, K., Radhakrishnan, K., McGlynn, L.M., Chee, M.M., Parkinson, E.K., Freeman, D., Madhok, R. and Shiels, P.G. (2008) Association of increased telomere lengths in limited scleroderma, with a lack of age-related telomere erosion. Annals of the Rheumatic Diseases, 67(12), pp. 1780-1782. (doi: 10.1136/ard.2007.086652)
Traynor, P., McGlynn, L.M., Mukherjee, R., Grimsley, S.L.S., Bartlett, J.M.S. and Edwards, J. (2008) An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients. Disease Markers, 24(3), pp. 157-165.
2007
Kirkegaard, T., McGlynn, L.M., Campbell, F.M., Muller, S., Tovey, S.M., Dunne, B., Nielsen, K.V., Cooke, T.G. and Bartlett, J.M. (2007) Amplified in breast cancer 1 in human epidermal growth factor receptor - positive tumors of tamoxifen-treated breast cancer patients. Clinical Cancer Research, 13(5), pp. 1405-1411. (doi: 10.1158/1078-0432.CCR-06-1933)
Tam, L., McGlynn, L.M., Traynor, P., Mukherjee, R., Bartlett, J.M.S. and Edwards, J. (2007) Expression levels of the JAK/STAT pathway in the transition from hormone-sensitive to hormone-refractory prostate cancer. British Journal of Cancer, 97(3), pp. 378-383. (doi: 10.1038/sj.bjc.6603871)
2006
Kirkegaard, T., Edwards, J. , Tovey, S., McGlynn, L.M., Krishna, S.N., Mukherjee, R., Tam, L., Munro, A.F., Dunne, B. and Bartlett, J.M. (2006) Observer variation in immunohistochemical analysis of protein expression, time for a change? Histopathology, 48(7), pp. 787-794. (doi: 10.1111/j.1365-2559.2006.02412.x)
2005
Kirkegaard, T., Witton, C.J., McGlynn, L.M., Tovey, S.M., Dunne, B., Lyon, A. and Bartlett, J.M. (2005) AKT activation predicts outcome in breast cancer patients treated with tamoxifen. Journal of Pathology, 207(2), pp. 139-146. (doi: 10.1002/path.1829)
Articles
Hill, C. et al. (2023) Differential methylation of telomere-related genes is associated with kidney disease in individuals with type 1 diabetes. Genes, 14(5), 1029. (doi: 10.3390/genes14051029) (PMID:37239390) (PMCID:PMC10217816)
Lu, L., Johnman, C., McGlynn, L., Mackay, D. F. , Shiels, P. G. and Pell, J. P. (2017) Association between exposure to second-hand smoke and telomere length: cross-sectional study of 1303 non-smokers. International Journal of Epidemiology, 46(6), pp. 1978-1984. (doi: 10.1093/ije/dyx212) (PMID:29040594)
Martin-Ruiz, C. M. et al. (2015) Is Southern blotting necessary to measure telomere length reproducibly? Authors’ Response to: Commentary: The reliability of telomere length measurements. International Journal of Epidemiology, 44(5), pp. 1686-1687. (doi: 10.1093/ije/dyv169) (PMID:26403813)
McGlynn, L. M., McCluney, S., Jamieson, N. B. , Thomson, J., MacDonald, A. I., Oien, K. , Dickson, E. J., Carter, C. R., McKay, C. J. and Shiels, P. G. (2015) SIRT3 & SIRT7: potential novel biomarkers for determining outcome in pancreatic cancer patients. PLoS ONE, 10(6), e0131344. (doi: 10.1371/journal.pone.0131344) (PMID:26121130) (PMCID:PMC4487247)
Martin-Ruiz, C. M. et al. (2015) Reproducibility of telomere length assessment: Authors’ Response to Damjan Krstajic and Ljubomir Buturovic. International Journal of Epidemiology, 44(5), pp. 1739-1741. (doi: 10.1093/ije/dyv170) (PMID:26403811)
Lu, L., Johnman, C., McGlynn, L., Mackay, D.F. , Shiels, P. and Pell, J.P. (2014) Association between telomere length, inflammation and cardiovascular risk. European Journal of Public Health, 24(S2), p. 273. (doi: 10.1093/eurpub/cku165.080)
Martin-Ruiz, C. M. et al. (2014) Reproducibility of telomere length assessment: an international collaborative study. International Journal of Epidemiology, 44(5), pp. 1673-1683. (doi: 10.1093/ije/dyu191) (PMID:25239152) (PMCID:PMC4681105)
McGlynn, L.M. et al. (2014) SIRT2: Tumour suppressor or tumour promoter in operable breast cancer? European Journal of Cancer, 50(2), pp. 290-301. (doi: 10.1016/j.ejca.2013.10.005) (PMID:24183459)
Rutherford, C. et al. (2013) Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1. Cell Death and Disease, 4(11), e927. (doi: 10.1038/cddis.2013.455)
McGlynn, L.M., Tovey, S., Bartlett, J.M.S., Doughty, J., Cooke, T.G. and Edwards, J. (2013) Interactions between MAP kinase and oestrogen receptor in human breast cancer. European Journal of Cancer, 49(6), pp. 1176-1186. (doi: 10.1016/j.ejca.2012.11.020)
McGlynn, L.M., Eller, K., MacDonald, A.I., MacIntyre, A., Russell, D., Koppelstaetter, C., Davies, R. and Shiels, P.G. (2013) Pathfinder cells provide a novel therapeutic intervention for acute kidney injury. Rejuvenation Research, 16(1), pp. 11-20. (doi: 10.1089/rej.2012.1350)
Gingell-Littlejohn, M., McGuinness, D., McGlynn, L.M., Kingsmore, D., Stevenson, K.S., Koppelstaetter, C., Clancy, M.J. and Shiels, P. (2013) Pre-transplant CDKN2A expression in kidney biopsies predicts renal function and is a future component of donor scoring criteria. PLoS ONE, 8(7), e68133. (doi: 10.1371/journal.pone.0068133) (PMID:23861858) (PMCID:PMC3701657)
Pathai, S. et al. (2013) Accelerated biological aging in HIV-infected individuals in South Africa: a case–control study. AIDS, 27(15), pp. 2375-2384. (doi: 10.1097/QAD.0b013e328363bf7f)
Roxburgh, C.S. , Richards, C.H., MacDonald, A.I., Powell, A.G., McGlynn, L.M., McMillan, D.C. , Horgan, P.G. , Edwards, J. and Shiels, P.G. (2013) The in situ local immune response, tumour senescence and proliferation in colorectal cancer. British Journal of Cancer, 109(8), pp. 2207-2216. (doi: 10.1038/bjc.2013.556)
Sebastián, C. et al. (2012) The histone deacetylase SIRT6 is a novel tumor suppressor that controls cancer metabolism. Cell, 151(6), pp. 1185-1199. (doi: 10.1016/j.cell.2012.10.047) (PMID:23217706) (PMCID:PMC3526953)
Robertson, T., Batty, G.D., Der, G., Green, M.J., McGlynn, L.M., McIntyre, A., Shiels, P.G. and Benzeval, M. (2012) Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 study. PLoS ONE, 7(7), e41805. (doi: 10.1371/journal.pone.0041805) (PMID:22844525) (PMCID:PMC3402400)
McGuinness, D. et al. (2012) Socio-economic status is associated with epigenetic differences in the pSoBid cohort. International Journal of Epidemiology, 41(1), pp. 151-160. (doi: 10.1093/ije/dyr215)
Der, G., Batty, G.D., Benzeval, M., Deary, I.J., Green, M.J., McGlynn, L., McIntyre, A., Robertson, T. and Shiels, P.G. (2012) Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland? PLoS ONE, 7(9), e45166. (doi: 10.1371/journal.pone.0045166) (PMID:23028820) (PMCID:PMC3454419)
Maxwell, F., McGlynn, L.M., Muir, H.C., Talwar, D., Benzeval, M., Robertson, T., Roxburgh, C.S., McMillan, D. , Horgan, P.G. and Shiels, P. (2011) Telomere attrition and decreased Fetuin A levels indicate accelerated biological ageing and are implicated in the pathogenesis of colorectal cancer. Clinical Cancer Research, 17(17), pp. 5573-5581. (doi: 10.1158/1078-0432.CCR-10-3271)
Shiels, P.G. et al. (2011) Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort. PLoS ONE, 6(7), e22521. (doi: 10.1371/journal.pone.0022521) (PMID:21818333) (PMCID:PMC3144896)
Stevenson, K. et al. (2011) Pancreatic derived pathfinder cells enable regeneration of critically damaged adult pancreatic tissue and completely reverse streptozotocin induced diabetes. Rejuvenation Research, 14(2), pp. 163-171. (doi: 10.1089/rej.2010.1099)
Watson, C., Long, J.S., Orange, C., Tannahill, C.L., Mallon, E., McGlynn, L.M., Pyne, S., Pyne, N.J. and Edwards, J. (2010) High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. American Journal of Pathology, 177(5), pp. 2205-2215. (doi: 10.2353/ajpath.2010.100220)
Stevenson, K.S., McGlynn, L.M., Hodge, M., McLinden, H., George, W.D., Davies, R.W. and Shiels, P.G. (2009) Isolation, characterization, and differentiation of Thy1.1-sorted pancreatic adult progenitor cell populations. Stem Cells and Development, 18(10), pp. 1389-1398. (doi: 10.1089/scd.2008.0301)
Stevenson, K.S., McGlynn, L.M. and Shiels, P.G. (2009) Stem cells: outstanding potential and outstanding questions. Scottish Medical Journal, 54(4), pp. 35-37. (doi: 10.1258/rsmsmj.54.4.35)
McGlynn, L.M., Kirkegaard, T., Edwards, J., Tovey, S., Cameron, D., Twelves, C., Bartlett, J.M.S. and Cooke, T.G. (2009) Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients. Clinical Cancer Research, 15(4), pp. 1487-1495. (doi: 10.1158/1078-0432.CCR-07-4967)
McGlynn, L.M., Stevenson, K., Lamb, K., Zino, S., Brown, M., Prina, A., Kingsmore, D. and Shiels, P.G. (2009) Cellular senescence in pre-transplant renal biopsies predicts postoperative organ function. Aging Cell, 8(1), pp. 45-51. (doi: 10.1111/j.1474-9726.2008.00447.x)
Brown, S.B.F., Mallon, E.A., Edwards, J., Campbell, F.M., McGlynn, L.M., Elsberger, B. and Cooke, T.G. (2009) Is the biology of breast cancer changing? A study of hormone receptor status 1984-1986 and 1996-1997. British Journal of Cancer, 100(5), pp. 807-810. (doi: 10.1038/sj.bjc.6604934)
Maclntyre, A., Brouilette, S.W., Lamb, K., Radhakrishnan, K., McGlynn, L.M., Chee, M.M., Parkinson, E.K., Freeman, D., Madhok, R. and Shiels, P.G. (2008) Association of increased telomere lengths in limited scleroderma, with a lack of age-related telomere erosion. Annals of the Rheumatic Diseases, 67(12), pp. 1780-1782. (doi: 10.1136/ard.2007.086652)
Traynor, P., McGlynn, L.M., Mukherjee, R., Grimsley, S.L.S., Bartlett, J.M.S. and Edwards, J. (2008) An increase in N-Ras expression is associated with development of hormone refractory prostate cancer in a subset of patients. Disease Markers, 24(3), pp. 157-165.
Kirkegaard, T., McGlynn, L.M., Campbell, F.M., Muller, S., Tovey, S.M., Dunne, B., Nielsen, K.V., Cooke, T.G. and Bartlett, J.M. (2007) Amplified in breast cancer 1 in human epidermal growth factor receptor - positive tumors of tamoxifen-treated breast cancer patients. Clinical Cancer Research, 13(5), pp. 1405-1411. (doi: 10.1158/1078-0432.CCR-06-1933)
Tam, L., McGlynn, L.M., Traynor, P., Mukherjee, R., Bartlett, J.M.S. and Edwards, J. (2007) Expression levels of the JAK/STAT pathway in the transition from hormone-sensitive to hormone-refractory prostate cancer. British Journal of Cancer, 97(3), pp. 378-383. (doi: 10.1038/sj.bjc.6603871)
Kirkegaard, T., Edwards, J. , Tovey, S., McGlynn, L.M., Krishna, S.N., Mukherjee, R., Tam, L., Munro, A.F., Dunne, B. and Bartlett, J.M. (2006) Observer variation in immunohistochemical analysis of protein expression, time for a change? Histopathology, 48(7), pp. 787-794. (doi: 10.1111/j.1365-2559.2006.02412.x)
Kirkegaard, T., Witton, C.J., McGlynn, L.M., Tovey, S.M., Dunne, B., Lyon, A. and Bartlett, J.M. (2005) AKT activation predicts outcome in breast cancer patients treated with tamoxifen. Journal of Pathology, 207(2), pp. 139-146. (doi: 10.1002/path.1829)
Conference Proceedings
Gardani, M. , McMillan, T., Shiels, P. , McGlynn, L. and Stewart, E. (2012) An investigation of biological ageing processes following head injury. In: International Brain Injury Association's Ninth World Congress on Brain Injury, Edinburgh, UK, 21-25 Mar 2012, pp. 679-680. (doi: 10.3109/02699052.2012.660091)
Gingell-Littlejohn, M., McGuinness, D., McGlynn, L. M., Kingsmore, D., Clancy, M. J., Koppelstaetter, C., Mayer, G. and Shiels, P.G. (2011) Telomere Length Impacts on Allograft Function Post Kidney Transplant. In: 2011 American Transplant Conference, Phildadelphia, PA, USA, 30 Apr - 4 May 2011,