Dr Francis Burton
- Research Technologist (Cardiovascular & Metabolic Health)
telephone:
01413306598
email:
Francis.Burton@glasgow.ac.uk
R406B Level 4, Institute of C&MS, West Medical Building, Glasgow G12 8QQ
Research interests
Research Theme: Cardiac Diseases
Role of Contraction-Excitation Feedback in Ventricular Arrythmogenesis*
Research groups
Publications
2024
Shead, K. D., Huethorst, E. , Burton, F., Lang, N. , Myles, R. C. and Smith, G. L. (2024) Human induced pluripotent stem cell derived cardiomyocytes for pre-clinical cardiotoxicity screening. JACC: CardioOncology, (Accepted for Publication)
Freeman, M., Huethorst, E. , Boland, E., Dunne, M., Burton, F., Denning, C., Myles, R. and Smith, G. (2024) A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit. American Journal of Physiology: Heart and Circulatory Physiology, 326(3), H735--H751. (doi: 10.1152/ajpheart.00657.2023) (PMID:38180449)
2023
Selli, A. L., Ghasemi, M., Watters, T., Burton, F., Smith, G. and Dietrichs, E. S. (2023) Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 31(1), 61. (doi: 10.1186/s13049-023-01134-5) (PMID:37880801) (PMCID:PMC10601188)
Lu, H. R., Van de Sande, D., Mohammadreza, G., Watters, T., Burton, F., Pham, L., Altrocchi, C., Gallacher, D. J. and Smith, G. (2023) Are more mature hiPSC-cardiomyocytes better for the detection of drug-induced cardiotoxicity? Biomolecules, 13(4), 676. (doi: 10.3390/biom13040676) (PMID:37189424) (PMCID:PMC10135569)
Alexander, C., Bishop, M. J., Gilchrist, R. J., Burton, F. L., Smith, G. L. and Myles, R. C. (2023) Initiation of ventricular arrhythmia in the acquired long QT syndrome. Cardiovascular Research, 119(2), pp. 465-476. (doi: 10.1093/cvr/cvac103) (PMID:35727943) (PMCID:PMC10064840)
2022
Lachaud, Q., Aziz, M. H. N., Burton, F. L., Macquaide, N. , Myles, R. C. , Simitev, R. D. and Smith, G. L. (2022) Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes. Cardiovascular Research, 118(15), pp. 3112-3125. (doi: 10.1093/cvr/cvab375) (PMID:35020837) (PMCID:PMC9732512)
Main, A. et al. (2022) Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies. Frontiers in Physiology, 13, 1023237. (doi: 10.3389/fphys.2022.1023237) (PMID:36277202) (PMCID:PMC9581287)
Huethorst, E. , Mortensen, P., Simitev, R. D. , Gao, H. , Pohjolainen, L., Talman, V., Ruskoaho, H., Burton, F. L., Gadegaard, N. and Smith, G. L. (2022) Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell derived cardiomyocytes. Journal of Physiology, 600(3), pp. 483-507. (doi: 10.1113/JP282228) (PMID:34761809) (PMCID:PMC9299844)
2021
Hortigon-Vinagre, M.P., Zamora, V., Burton, F. L. and Smith, G. L. (2021) The use of voltage sensitive dye di-4-ANEPPS and video-based contractility measurements to assess drug effects on excitation-contraction coupling in human induced pluripotent stem cell-derived cardiomyocytes. Journal of Cardiovascular Pharmacology, 77(3), pp. 280-290. (doi: 10.1097/FJC.0000000000000937) (PMID:33109927)
Burton, R. F. and Burton, F. L. (2021) When is sitting height a better measure of adult body size than total height, and why? The contrasting examples of body mass, waist circumference and lung volume. American Journal of Human Biology, 33(1), e23433. (doi: 10.1002/ajhb.23433) (PMID:32530561)
Da Silva Costa, A. , Mortensen, P., Hortigon-Vinagre, M. P., van der Heyden, M. A. G., Burton, F. L., Gao, H. , Simitev, R. D. and Smith, G. L. (2021) Electrophysiology of hiPSC-cardiomyocytes co-cultured with HEK cells expressing the inward rectifier channel. International Journal of Molecular Sciences, 22(12), 6621. (doi: 10.3390/ijms22126621)
2020
Dietrichs, E. S., McGlynn, K., Allan, A., Connolly, A., Bishop, M., Burton, F., Kettlewell, S., Myles, R. , Tveita, T. and Smith, G. L. (2020) Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology. Cardiovascular Research, 116(13), pp. 2081-2090. (doi: 10.1093/cvr/cvz309) (PMID:32031595) (PMCID:PMC7584464)
2018
Henry, A. D., MacQuaide, N. , Burton, F.L., Rankin, A.C., Rowan, E.G. and Drummond, R.M. (2018) Spontaneous Ca2+ transients in rat pulmonary vein cardiomyocytes are increased in frequency and become more synchronous following electrical stimulation. Cell calcium, 76, pp. 36-47. (doi: 10.1016/j.ceca.2018.09.001) (PMID:30253263)
van Meer, B. J., Sala, L., Tertoolen, L. G.J., Smith, G. L. , Burton, F. L. and Mummery, C. L. (2018) Quantification of muscle contraction in vitro and in vivo using MUSCLEMOTION software: from stem cell-derived cardiomyocytes to zebrafish and human hearts. Current Protocols in Human Genetics, 99(1), e67. (doi: 10.1002/cphg.67) (PMID:30253059)
Sala, L. et al. (2018) MUSCLEMOTION: a versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo. Circulation Research, 122(3), e5-e16. (doi: 10.1161/CIRCRESAHA.117.312067) (PMID:29282212) (PMCID:PMC5805275)
Lachaud, Q., MacQuaide, N. , Burton, F. and Smith, G. (2018) High-throughput study of rabbit ventricle action potential populations in MI model. Biophysical Journal, 114(3.S1), 625A. (doi: 10.1016/j.bpj.2017.11.3377)
2016
Huethorst, E., Hortigon, M. , Zamora-Rodriguez, V., Reynolds, P.M. , Burton, F., Smith, G. and Gadegaard, N. (2016) Enhanced human-induced pluripotent stem cell derived cardiomyocyte maturation using a dual microgradient substrate. ACS Biomaterials Science and Engineering, 2(12), pp. 2231-2239. (doi: 10.1021/acsbiomaterials.6b00426) (PMID:27990488) (PMCID:PMC5155309)
Hortigon-Vinagre, M.P., Zamora, V., Burton, F.L., Green, J., Gintant, G.A. and Smith, G.L. (2016) The use of ratiometric fluorescence measurements of the voltage sensitive dye Di-4-ANEPPS to examine action potential characteristics and drug effects on human induced pluripotent stem cell-derived cardiomyocytes. Toxicological Sciences, 154(2), pp. 320-331. (doi: 10.1093/toxsci/kfw171) (PMID:27621282) (PMCID:PMC5139069)
Nisbet, A. M., Camelliti, P., Walker, N. L., Burton, F. L., Cobbe, S. M., Kohl, P. and Smith, G. L. (2016) Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: role of fibrosis and connexin remodelling. Journal of Molecular and Cellular Cardiology, 94, pp. 54-64. (doi: 10.1016/j.yjmcc.2016.03.011) (PMID:27021518) (PMCID:PMC4873602)
2015
Hu, D. et al. (2015) Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity, 42(6), pp. 1100-1115. (doi: 10.1016/j.immuni.2015.05.015) (PMID:26084025) (PMCID:PMC4678289)
Ghouri, I. A., Kelly, A., Burton, F. L., Smith, G. L. and Kemi, O. J. (2015) 2-photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca2+in intact mice, rat, and rabbit hearts. Journal of Biophotonics, 8(1-2), pp. 112-123. (doi: 10.1002/jbio.201300109)
2014
Campbell, A. S., Burton, F. L., Baillie, G. and Smith, G. L. (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway. In: 58th Annual Meeting of the Biophysical-Society, San Francisco CA, USA, 15-19 Feb 2014, 119a.
Nisbet, A. M., Burton, F. L., Walker, N. L., Craig, M. A., Cheng, H., Hancox, J. C., Orchard, C. H. and Smith, G. L. (2014) Acidosis slows electrical conduction through the atrio-ventricular node. Frontiers in Physiology, 5(233), (doi: 10.3389/fphys.2014.00233)
2013
Kettlewell, S., Burton, F. L., Smith, G. L. and Workman, A. J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi: 10.1093/cvr/cvt087) (PMID:23568957) (PMCID:PMC3687753)
Di Diego, J.M., Sicouri, S., Myles, R.C. , Burton, F., Smith, G.L. and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi: 10.1016/j.yjmcc.2012.10.017)
Kelly, A., Ghouri, I.A., Kemi, O.J. , Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C. , Burton, F.L. and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi: 10.1161/CIRCEP.113.000334)
2012
Cheng, H., Smith, G.L. , Orchard, C.H., Hancox, J.C. and Burton, F.L. (2012) Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits. Experimental Physiology, 97(10), pp. 1131-1139. (doi: 10.1113/expphysiol.2012.065110)
2011
Myles, R. , Burton, F.L., Cobbe, S. and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi: 10.1016/j.yjmcc.2010.11.019)
2010
Burton, F.L., Malkova, D. , Caslake, M.J. and Gill, J.M.R. (2010) Substrate metabolism, appetite and feeding behaviour under low and high energy turnover conditions in overweight women. British Journal of Nutrition, 104(8), pp. 1249-1259. (doi: 10.1017/S0007114510002023)
Myles, R.C. , Bernus, O., Burton, F.L., Cobbe, S.M. and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi: 10.1152/ajpheart.00518.2010)
Smith, G. , Reynolds, M., Burton, F.L. and Kemi, O.J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. Methods in Cell Biology, 99(10), pp. 255-261. (doi: 10.1016/B978-0-12-374841-6.00009-8)
Smith, G. , Reynolds, M., Burton, F. and Kemi, O. J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. In: Whitaker, M. (ed.) Calcium in Living Cells. Series: Methods in cell biology (99). Elsevier, pp. 225-261. ISBN 9780123748416 (doi: 10.1016/B978-0-12-374841-6.00009-8)
2008
Burton, F.L., Malkova, D. , Caslake, M.J. and Gill, J.M.R. (2008) Energy replacement attenuates the effects of prior moderate exercise on postprandial metabolism in overweight/obese men. International Journal of Obesity, 32(3), pp. 481-489. (doi: 10.1038/sj.ijo.0803754)
Lang, N.N. , Myles, R.C., Burton, F.L., Hall, D.P., Chin, Y.Z., Boon, N.A. and Newby, D.E. (2008) The vascular effects of rotigaptide in vivo in man. Biochemical Pharmacology, 76(10), pp. 1194-1200. (doi: 10.1016/j.bcp.2008.08.022)
Myles, R.C. , Burton, F.L., Cobbe, S.M. and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi: 10.1016/j.yjmcc.2008.03.024)
2007
Caldwell, J., Burton, F., Smith, G. and Cobbe, S. (2007) Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 18(8), pp. 854-861. (doi: 10.1111/j.1540-8167.2007.00867.x)
Walker, N., Burton, F., Kettlewell, S., Smith, G. and Cobbe, S. (2007) Mapping of epicardial activation in a rabbit model of chronic myocardial infarction: Response to atrial, endocardial, and epicardial pacing. Journal of Cardiovascular Electrophysiology, 18(8), pp. 862-868. (doi: 10.1111/j.1540-8167.2007.00858.x)
2005
Kohl, P., Camelliti, P., Burton, F. and Smith, G. (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of Electrocardiology, 38(4), pp. 45-50. (doi: 10.1016/j.jelectrocard.2005.06.096)
2004
Kettlewell, S., Walker, N., Cobbe, S., Burton, F. and Smith, G. (2004) The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Experimental Physiology, 89(2), pp. 163-172. (doi: 10.1113/expphysiol.2003.026732)
Articles
Shead, K. D., Huethorst, E. , Burton, F., Lang, N. , Myles, R. C. and Smith, G. L. (2024) Human induced pluripotent stem cell derived cardiomyocytes for pre-clinical cardiotoxicity screening. JACC: CardioOncology, (Accepted for Publication)
Freeman, M., Huethorst, E. , Boland, E., Dunne, M., Burton, F., Denning, C., Myles, R. and Smith, G. (2024) A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit. American Journal of Physiology: Heart and Circulatory Physiology, 326(3), H735--H751. (doi: 10.1152/ajpheart.00657.2023) (PMID:38180449)
Selli, A. L., Ghasemi, M., Watters, T., Burton, F., Smith, G. and Dietrichs, E. S. (2023) Proarrhythmic changes in human cardiomyocytes during hypothermia by milrinone and isoprenaline, but not levosimendan: an experimental in vitro study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 31(1), 61. (doi: 10.1186/s13049-023-01134-5) (PMID:37880801) (PMCID:PMC10601188)
Lu, H. R., Van de Sande, D., Mohammadreza, G., Watters, T., Burton, F., Pham, L., Altrocchi, C., Gallacher, D. J. and Smith, G. (2023) Are more mature hiPSC-cardiomyocytes better for the detection of drug-induced cardiotoxicity? Biomolecules, 13(4), 676. (doi: 10.3390/biom13040676) (PMID:37189424) (PMCID:PMC10135569)
Alexander, C., Bishop, M. J., Gilchrist, R. J., Burton, F. L., Smith, G. L. and Myles, R. C. (2023) Initiation of ventricular arrhythmia in the acquired long QT syndrome. Cardiovascular Research, 119(2), pp. 465-476. (doi: 10.1093/cvr/cvac103) (PMID:35727943) (PMCID:PMC10064840)
Lachaud, Q., Aziz, M. H. N., Burton, F. L., Macquaide, N. , Myles, R. C. , Simitev, R. D. and Smith, G. L. (2022) Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes. Cardiovascular Research, 118(15), pp. 3112-3125. (doi: 10.1093/cvr/cvab375) (PMID:35020837) (PMCID:PMC9732512)
Main, A. et al. (2022) Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies. Frontiers in Physiology, 13, 1023237. (doi: 10.3389/fphys.2022.1023237) (PMID:36277202) (PMCID:PMC9581287)
Huethorst, E. , Mortensen, P., Simitev, R. D. , Gao, H. , Pohjolainen, L., Talman, V., Ruskoaho, H., Burton, F. L., Gadegaard, N. and Smith, G. L. (2022) Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell derived cardiomyocytes. Journal of Physiology, 600(3), pp. 483-507. (doi: 10.1113/JP282228) (PMID:34761809) (PMCID:PMC9299844)
Hortigon-Vinagre, M.P., Zamora, V., Burton, F. L. and Smith, G. L. (2021) The use of voltage sensitive dye di-4-ANEPPS and video-based contractility measurements to assess drug effects on excitation-contraction coupling in human induced pluripotent stem cell-derived cardiomyocytes. Journal of Cardiovascular Pharmacology, 77(3), pp. 280-290. (doi: 10.1097/FJC.0000000000000937) (PMID:33109927)
Burton, R. F. and Burton, F. L. (2021) When is sitting height a better measure of adult body size than total height, and why? The contrasting examples of body mass, waist circumference and lung volume. American Journal of Human Biology, 33(1), e23433. (doi: 10.1002/ajhb.23433) (PMID:32530561)
Da Silva Costa, A. , Mortensen, P., Hortigon-Vinagre, M. P., van der Heyden, M. A. G., Burton, F. L., Gao, H. , Simitev, R. D. and Smith, G. L. (2021) Electrophysiology of hiPSC-cardiomyocytes co-cultured with HEK cells expressing the inward rectifier channel. International Journal of Molecular Sciences, 22(12), 6621. (doi: 10.3390/ijms22126621)
Dietrichs, E. S., McGlynn, K., Allan, A., Connolly, A., Bishop, M., Burton, F., Kettlewell, S., Myles, R. , Tveita, T. and Smith, G. L. (2020) Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology. Cardiovascular Research, 116(13), pp. 2081-2090. (doi: 10.1093/cvr/cvz309) (PMID:32031595) (PMCID:PMC7584464)
Henry, A. D., MacQuaide, N. , Burton, F.L., Rankin, A.C., Rowan, E.G. and Drummond, R.M. (2018) Spontaneous Ca2+ transients in rat pulmonary vein cardiomyocytes are increased in frequency and become more synchronous following electrical stimulation. Cell calcium, 76, pp. 36-47. (doi: 10.1016/j.ceca.2018.09.001) (PMID:30253263)
van Meer, B. J., Sala, L., Tertoolen, L. G.J., Smith, G. L. , Burton, F. L. and Mummery, C. L. (2018) Quantification of muscle contraction in vitro and in vivo using MUSCLEMOTION software: from stem cell-derived cardiomyocytes to zebrafish and human hearts. Current Protocols in Human Genetics, 99(1), e67. (doi: 10.1002/cphg.67) (PMID:30253059)
Sala, L. et al. (2018) MUSCLEMOTION: a versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo. Circulation Research, 122(3), e5-e16. (doi: 10.1161/CIRCRESAHA.117.312067) (PMID:29282212) (PMCID:PMC5805275)
Lachaud, Q., MacQuaide, N. , Burton, F. and Smith, G. (2018) High-throughput study of rabbit ventricle action potential populations in MI model. Biophysical Journal, 114(3.S1), 625A. (doi: 10.1016/j.bpj.2017.11.3377)
Huethorst, E., Hortigon, M. , Zamora-Rodriguez, V., Reynolds, P.M. , Burton, F., Smith, G. and Gadegaard, N. (2016) Enhanced human-induced pluripotent stem cell derived cardiomyocyte maturation using a dual microgradient substrate. ACS Biomaterials Science and Engineering, 2(12), pp. 2231-2239. (doi: 10.1021/acsbiomaterials.6b00426) (PMID:27990488) (PMCID:PMC5155309)
Hortigon-Vinagre, M.P., Zamora, V., Burton, F.L., Green, J., Gintant, G.A. and Smith, G.L. (2016) The use of ratiometric fluorescence measurements of the voltage sensitive dye Di-4-ANEPPS to examine action potential characteristics and drug effects on human induced pluripotent stem cell-derived cardiomyocytes. Toxicological Sciences, 154(2), pp. 320-331. (doi: 10.1093/toxsci/kfw171) (PMID:27621282) (PMCID:PMC5139069)
Nisbet, A. M., Camelliti, P., Walker, N. L., Burton, F. L., Cobbe, S. M., Kohl, P. and Smith, G. L. (2016) Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: role of fibrosis and connexin remodelling. Journal of Molecular and Cellular Cardiology, 94, pp. 54-64. (doi: 10.1016/j.yjmcc.2016.03.011) (PMID:27021518) (PMCID:PMC4873602)
Hu, D. et al. (2015) Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity, 42(6), pp. 1100-1115. (doi: 10.1016/j.immuni.2015.05.015) (PMID:26084025) (PMCID:PMC4678289)
Ghouri, I. A., Kelly, A., Burton, F. L., Smith, G. L. and Kemi, O. J. (2015) 2-photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca2+in intact mice, rat, and rabbit hearts. Journal of Biophotonics, 8(1-2), pp. 112-123. (doi: 10.1002/jbio.201300109)
Nisbet, A. M., Burton, F. L., Walker, N. L., Craig, M. A., Cheng, H., Hancox, J. C., Orchard, C. H. and Smith, G. L. (2014) Acidosis slows electrical conduction through the atrio-ventricular node. Frontiers in Physiology, 5(233), (doi: 10.3389/fphys.2014.00233)
Kettlewell, S., Burton, F. L., Smith, G. L. and Workman, A. J. (2013) Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarisations and fibrillation. Cardiovascular Research, 99(1), pp. 215-224. (doi: 10.1093/cvr/cvt087) (PMID:23568957) (PMCID:PMC3687753)
Di Diego, J.M., Sicouri, S., Myles, R.C. , Burton, F., Smith, G.L. and Antzelevitch, C. (2013) Optical and electrical recordings from isolated coronary-perfused ventricular wedge preparations. Journal of Molecular and Cellular Cardiology, 54, pp. 53-64. (doi: 10.1016/j.yjmcc.2012.10.017)
Kelly, A., Ghouri, I.A., Kemi, O.J. , Bishop, M.J., Bernus, O., Fenton, F.H., Myles, R.C. , Burton, F.L. and Smith, G.L. (2013) Subepicardial action potential characteristics are a function of depth and activation sequence in isolated rabbit hearts. Circulation: Arrhythmia and Electrophysiology, 6(4), pp. 809-817. (doi: 10.1161/CIRCEP.113.000334)
Cheng, H., Smith, G.L. , Orchard, C.H., Hancox, J.C. and Burton, F.L. (2012) Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits. Experimental Physiology, 97(10), pp. 1131-1139. (doi: 10.1113/expphysiol.2012.065110)
Myles, R. , Burton, F.L., Cobbe, S. and Smith, G.L. (2011) Alternans of action potential duration and amplitude in rabbits with left ventricular dysfunction following myocardial infarction. Journal of Molecular and Cellular Cardiology, 50(3), pp. 510-512. (doi: 10.1016/j.yjmcc.2010.11.019)
Burton, F.L., Malkova, D. , Caslake, M.J. and Gill, J.M.R. (2010) Substrate metabolism, appetite and feeding behaviour under low and high energy turnover conditions in overweight women. British Journal of Nutrition, 104(8), pp. 1249-1259. (doi: 10.1017/S0007114510002023)
Myles, R.C. , Bernus, O., Burton, F.L., Cobbe, S.M. and Smith, G.L. (2010) The effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium. American Journal of Physiology: Heart and Circulatory Physiology, 289(8), H1812-H1822. (doi: 10.1152/ajpheart.00518.2010)
Smith, G. , Reynolds, M., Burton, F.L. and Kemi, O.J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. Methods in Cell Biology, 99(10), pp. 255-261. (doi: 10.1016/B978-0-12-374841-6.00009-8)
Burton, F.L., Malkova, D. , Caslake, M.J. and Gill, J.M.R. (2008) Energy replacement attenuates the effects of prior moderate exercise on postprandial metabolism in overweight/obese men. International Journal of Obesity, 32(3), pp. 481-489. (doi: 10.1038/sj.ijo.0803754)
Lang, N.N. , Myles, R.C., Burton, F.L., Hall, D.P., Chin, Y.Z., Boon, N.A. and Newby, D.E. (2008) The vascular effects of rotigaptide in vivo in man. Biochemical Pharmacology, 76(10), pp. 1194-1200. (doi: 10.1016/j.bcp.2008.08.022)
Myles, R.C. , Burton, F.L., Cobbe, S.M. and Smith, G.L. (2008) The link between repolarisation alternans and ventricular arrhythmia: Does the cellular phenomenon extend to the clinical problem? Journal of Molecular and Cellular Cardiology, 45(1), pp. 1-10. (doi: 10.1016/j.yjmcc.2008.03.024)
Caldwell, J., Burton, F., Smith, G. and Cobbe, S. (2007) Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts. Journal of Cardiovascular Electrophysiology, 18(8), pp. 854-861. (doi: 10.1111/j.1540-8167.2007.00867.x)
Walker, N., Burton, F., Kettlewell, S., Smith, G. and Cobbe, S. (2007) Mapping of epicardial activation in a rabbit model of chronic myocardial infarction: Response to atrial, endocardial, and epicardial pacing. Journal of Cardiovascular Electrophysiology, 18(8), pp. 862-868. (doi: 10.1111/j.1540-8167.2007.00858.x)
Kohl, P., Camelliti, P., Burton, F. and Smith, G. (2005) Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation. Journal of Electrocardiology, 38(4), pp. 45-50. (doi: 10.1016/j.jelectrocard.2005.06.096)
Kettlewell, S., Walker, N., Cobbe, S., Burton, F. and Smith, G. (2004) The electrophysiological and mechanical effects of 2,3-butane-dione monoxime and cytochalasin-D in the Langendorff perfused rabbit heart. Experimental Physiology, 89(2), pp. 163-172. (doi: 10.1113/expphysiol.2003.026732)
Book Sections
Smith, G. , Reynolds, M., Burton, F. and Kemi, O. J. (2010) Confocal and multiphoton imaging of intracellular Ca2+. In: Whitaker, M. (ed.) Calcium in Living Cells. Series: Methods in cell biology (99). Elsevier, pp. 225-261. ISBN 9780123748416 (doi: 10.1016/B978-0-12-374841-6.00009-8)
Conference Proceedings
Campbell, A. S., Burton, F. L., Baillie, G. and Smith, G. L. (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway. In: 58th Annual Meeting of the Biophysical-Society, San Francisco CA, USA, 15-19 Feb 2014, 119a.
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Cardiac gene therapy with angiotensin-(1-9): dissecting the underlying mechanism for preservation of cardiac function post-myocardial infarction
British Heart Foundation
2017 - 2020
- Atrial remodelling of calcium handling and electrophysiology in heart failure.
British Heart Foundation
2009 - 2013
- Cellular basis for alternating T-wave morphology in isolated rabbit hearts
British Heart Foundation
2009 - 2012
- Atrioventricular nodal function in a rabbit model of chronic heart failure
British Heart Foundation
2005 - 2007
- Factors affecting the success of defibrillation in ischaemia
British Heart Foundation
2004 - 2007
Supervision
- Gilchrist, Rebecca
Characterising the Spatial Heterogeneity of Ventricular Electrophysiology under Physiological and Long QT Conditions