Dr Eline Huethorst
- Research Associate (Cardiovascular & Metabolic Health)
telephone:
01413304734
email:
Eline.Huethorst@glasgow.ac.uk
pronouns:
She/her/hers
Room 416, Sir James Black Building, University of Glasgow Campus, G12 8QQ
https://orcid.org/0000-0003-1900-4039Biography
Eline started her academic career in the Netherlands with an undergraduate in Life Sciences from the University of Groningen, where she gained interest in the field of Regenerative Medicine. She therefore decided to do a postgraduate in Regenerative Medicine at the University of Utrecht. Afterwards, she was awarded a 4-year PHD studentship by the British Heart Foundation and started working at the University of Glasgow to study how small, engineered heart tissues could integrate with the myocardium after implantation.
Eline is now a Research Associate at the University of Glasgow and part of the Glasgow Cardiac Research Centre. Eline is also part of the BHF Centre for Regenerative Medicine, which is a network of universities within the UK that all work together to tackle the big challenges within cardiac regeneration to be able to treat patients that have suffered a heart attack with new cell therapies in the future.
Research interests
Research Theme: Cardiac Diseases
Research groups
Publications
2025
Huethorst, E. , Bishop, M. J., Burton, F.L., Denning, C., Gadegaard, N. , Myles, R.C. and Smith, G.L. (2025) Evidence for intermittent coupling of intramyocardial small, engineered heart tissues acutely implanted into rabbit myocardium. Cardiovascular Research, (Accepted for Publication)
2024
Shead, K. D., Huethorst, E. , Burton, F., Lang, N. , Myles, R. C. and Smith, G. L. (2024) Human induced pluripotent stem cell-derived cardiomyocytes for preclinical cardiotoxicity screening in cardio-oncology. JACC: CardioOncology, 6(5), pp. 678-683. (doi: 10.1016/j.jaccao.2024.07.012) (PMID:39479327) (PMCID:PMC11520213)
Astrauskaite, G., Mohanan, S. , Williamson, L., Boland, E., Huethorst, E. , Kinegawa, R., Smith, G. and Muellenbroich, C. (2024) Remote Focusing for 2-photon Microscopy to Follow Action Potential Propagation Transmurally in Acute Rabbit Cardiac Slices. In: SPIE BiOS 2024, San Francisco, CA, USA, 27 January - 1 February 2024, ISBN 9781510669536 (doi: 10.1117/12.3002956)
Freeman, M., Huethorst, E. , Boland, E., Dunne, M., Burton, F., Denning, C., Myles, R. and Smith, G. (2024) A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit. American Journal of Physiology: Heart and Circulatory Physiology, 326(3), H735--H751. (doi: 10.1152/ajpheart.00657.2023) (PMID:38180449)
Astrauskaitė, G., Williamson, L., Mohanan, S. , Moreno, S. M., Kinegawa, R., Boland, E., Huethorst, E. , Smith, G. and Müllenbroich, C. (2024) Fast Axial Scanning with Remote Focusing for Multiphoton Microscopy of Acute Rabbit Ventricular Slices to Follow Action Potentials Transmurally. In: Conference on Lasers and Electro-Optics (CLEO) 2024: Science and Innovations, Charlotte, North Carolina, USA, 05-10 May 2024, SF2B.1. ISBN 9781957171395 (doi: 10.1364/CLEO_SI.2024.SF2B.1)
2022
Huethorst, E. , Mortensen, P., Simitev, R. D. , Gao, H. , Pohjolainen, L., Talman, V., Ruskoaho, H., Burton, F. L., Gadegaard, N. and Smith, G. L. (2022) Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell derived cardiomyocytes. Journal of Physiology, 600(3), pp. 483-507. (doi: 10.1113/JP282228) (PMID:34761809) (PMCID:PMC9299844)
2020
Huethorst, E. , Cutiongco, M. F.A. , Campbell, F. A., Saeed, A. , Love, R., Reynolds, P. M. , Dalby, M. J. and Gadegaard, N. (2020) Customizable, engineered substrates for rapid screening of cellular cues. Biofabrication, 12(2), 025009. (doi: 10.1088/1758-5090/ab5d3f) (PMID:31783378) (PMCID:PMC7655147)
2016
Huethorst, E., Hortigon, M. , Zamora-Rodriguez, V., Reynolds, P.M. , Burton, F., Smith, G. and Gadegaard, N. (2016) Enhanced human-induced pluripotent stem cell derived cardiomyocyte maturation using a dual microgradient substrate. ACS Biomaterials Science and Engineering, 2(12), pp. 2231-2239. (doi: 10.1021/acsbiomaterials.6b00426) (PMID:27990488) (PMCID:PMC5155309)
Huethorst, E. , Krebber, M. M., Fledderus, J. O., Gremmels, H., Xu, Y. J., Pei, J., Verhaar, M. C. and Cheng, C. (2016) Lymphatic Vascular Regeneration: The Next Step in Tissue Engineering. Tissue Engineering Part B: Reviews, 22(1), pp. 1-14. (doi: 10.1089/ten.teb.2015.0231) (PMID:26204330)
Articles
Huethorst, E. , Bishop, M. J., Burton, F.L., Denning, C., Gadegaard, N. , Myles, R.C. and Smith, G.L. (2025) Evidence for intermittent coupling of intramyocardial small, engineered heart tissues acutely implanted into rabbit myocardium. Cardiovascular Research, (Accepted for Publication)
Shead, K. D., Huethorst, E. , Burton, F., Lang, N. , Myles, R. C. and Smith, G. L. (2024) Human induced pluripotent stem cell-derived cardiomyocytes for preclinical cardiotoxicity screening in cardio-oncology. JACC: CardioOncology, 6(5), pp. 678-683. (doi: 10.1016/j.jaccao.2024.07.012) (PMID:39479327) (PMCID:PMC11520213)
Freeman, M., Huethorst, E. , Boland, E., Dunne, M., Burton, F., Denning, C., Myles, R. and Smith, G. (2024) A novel method for the percutaneous induction of myocardial infarction by occlusion of small coronary arteries in the rabbit. American Journal of Physiology: Heart and Circulatory Physiology, 326(3), H735--H751. (doi: 10.1152/ajpheart.00657.2023) (PMID:38180449)
Huethorst, E. , Mortensen, P., Simitev, R. D. , Gao, H. , Pohjolainen, L., Talman, V., Ruskoaho, H., Burton, F. L., Gadegaard, N. and Smith, G. L. (2022) Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell derived cardiomyocytes. Journal of Physiology, 600(3), pp. 483-507. (doi: 10.1113/JP282228) (PMID:34761809) (PMCID:PMC9299844)
Huethorst, E. , Cutiongco, M. F.A. , Campbell, F. A., Saeed, A. , Love, R., Reynolds, P. M. , Dalby, M. J. and Gadegaard, N. (2020) Customizable, engineered substrates for rapid screening of cellular cues. Biofabrication, 12(2), 025009. (doi: 10.1088/1758-5090/ab5d3f) (PMID:31783378) (PMCID:PMC7655147)
Huethorst, E., Hortigon, M. , Zamora-Rodriguez, V., Reynolds, P.M. , Burton, F., Smith, G. and Gadegaard, N. (2016) Enhanced human-induced pluripotent stem cell derived cardiomyocyte maturation using a dual microgradient substrate. ACS Biomaterials Science and Engineering, 2(12), pp. 2231-2239. (doi: 10.1021/acsbiomaterials.6b00426) (PMID:27990488) (PMCID:PMC5155309)
Huethorst, E. , Krebber, M. M., Fledderus, J. O., Gremmels, H., Xu, Y. J., Pei, J., Verhaar, M. C. and Cheng, C. (2016) Lymphatic Vascular Regeneration: The Next Step in Tissue Engineering. Tissue Engineering Part B: Reviews, 22(1), pp. 1-14. (doi: 10.1089/ten.teb.2015.0231) (PMID:26204330)
Conference Proceedings
Astrauskaite, G., Mohanan, S. , Williamson, L., Boland, E., Huethorst, E. , Kinegawa, R., Smith, G. and Muellenbroich, C. (2024) Remote Focusing for 2-photon Microscopy to Follow Action Potential Propagation Transmurally in Acute Rabbit Cardiac Slices. In: SPIE BiOS 2024, San Francisco, CA, USA, 27 January - 1 February 2024, ISBN 9781510669536 (doi: 10.1117/12.3002956)
Astrauskaitė, G., Williamson, L., Mohanan, S. , Moreno, S. M., Kinegawa, R., Boland, E., Huethorst, E. , Smith, G. and Müllenbroich, C. (2024) Fast Axial Scanning with Remote Focusing for Multiphoton Microscopy of Acute Rabbit Ventricular Slices to Follow Action Potentials Transmurally. In: Conference on Lasers and Electro-Optics (CLEO) 2024: Science and Innovations, Charlotte, North Carolina, USA, 05-10 May 2024, SF2B.1. ISBN 9781957171395 (doi: 10.1364/CLEO_SI.2024.SF2B.1)