Dr Elaine Rutherford
- Honorary Clinical Senior Lecturer (School of Cardiovascular & Metabolic Health)
email:
Elaine.Rutherford@glasgow.ac.uk
Dumfries and Galloway Royal Infirmary, Cargenbridge, Dumfries, DG2 8RX
Biography
Dr Rutherford undertook her undergraduate medical studies at the University of Aberdeen (2002-2007 MBChB) where she won the Smith Shand award for the student with the best mark in clinical finals. She undertook medical training post-qualification n Aberdeen and Dundee before moving to Glasgow in 2012 to commence speciality training in nephrology and general internal medicine. Between 2013-2016 she took time out of programme to complete a PhD as a research fellow at the University of Dundee. Following her PHD Dr Rutherford has been employed as a clinical lecturer at the University of Glasgow.
Research interests
The cardiovascular complications of chronic kidney disease
Clinical trials
Publications
2024
Chen, D. C. et al. (2024) Cystatin C- and creatinine-based estimated GFR differences: prevalence and predictors in the UK Biobank. Kidney Medicine, 6(4), 100796. (doi: 10.1016/j.xkme.2024.100796) (PMID:8567244) (PMCID:PMC10986041)
2023
Lees, J. S. , De La Mata, N. L., Sullivan, M. K. , Wyld, M. L., Rosales, B. M., Cutting, R., Hedley, J. A., Rutherford, E., Mark, P. B. and Webster, A. C. (2023) Sex differences in associations between creatinine and cystatin C-based kidney function measures with stroke and major bleeding. European Stroke Journal, 8(3), pp. 756-768. (doi: 10.1177/23969873231173282)
Mayne, K. J., Lees, J. S. , Rutherford, E., Thomson, P. C., Traynor, J. P., Dey, V. , Lang, N. N. and Mark, P. B. (2023) Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios: associations with mortality in a haemodialysis cohort. Clinical Kidney Journal, 16(3), pp. 512-520. (doi: 10.1093/ckj/sfac248) (PMID:36865003) (PMCID:PMC9972818)
Chen, D. C., Lees, J. S. , Lu, K., Scherzer, R., Rutherford, E., Mark, P. B. , Kanaya, A. M., Shlipak, M. G. and Estrella, M. M. (2023) Differential associations of cystatin C versus creatinine‐based kidney function with risks of cardiovascular event and mortality among South Asian individuals in the UK Biobank. Journal of the American Heart Association, 12(3), e027079. (doi: 10.1161/JAHA.122.027079) (PMID:36695320) (PMCID:PMC9973614)
Sullivan, M. K. et al. (2023) Potential impact of NICE guidelines on referrals from primary care to nephrology: a primary care database and prospective research study. British Journal of General Practice, 73(727), e141-e147. (doi: 10.3399/BJGP.2022.0145) (PMID:36376072) (PMCID:PMC9678375)
2022
Mark, P. B. , Mangion, K., Rankin, A. J. , Rutherford, E., Lang, N. N. , Petrie, M. C. , Stoumpos, S. and Patel, R. K. (2022) Left ventricular dysfunction with preserved ejection fraction: the most common left ventricular disorder in chronic kidney disease patients. Clinical Kidney Journal, 15(12), pp. 2186-2199. (doi: 10.1093/ckj/sfac146) (PMID:36381379) (PMCID:PMC9664574)
Rutherford, E., Leach, J. F., Bennett, E. J.A., Rutherford, J. S., Urquhart, L., Watt, E., Allen, R. M., Wrathall, D. W., Williams, D. and Muniraju, T. M. (2022) Acute intermittent renal replacement therapy in a rural Scottish intensive care unit – a review of patient and renal outcomes. Journal of the Intensive Care Society, 23(4), pp. 503-505. (doi: 10.1177/17511437211018616)
Lees, J. S. , Rutherford, E., Stevens, K. I., Chen, D. C., Scherzer, R., Estrella, M. M., Sullivan, M. K. , Ebert, N., Mark, P. B. and Shlipak, M. G. (2022) Assessment of Cystatin C level for risk stratification in adults with chronic kidney disease. JAMA Network Open, 5(10), e2238300. (doi: 10.1001/jamanetworkopen.2022.38300) (PMID:36282503) (PMCID:PMC9597396)
Lees, J. , Rutherford, E., Stevens, K., Chen, D., Scherzer, R., Estrella, M., Sullivan, M. , Ebert, N., Mark, P. and Shlipak, M. (2022) FC077: Cystatin C testing improves risk stratification associated with chronic kidney disease without adopting age-adapted diagnostic thresholds : a UK Biobank Study. Nephrology Dialysis Transplantation, 37(Sup 3), I842-I843. (doi: 10.1093/ndt/gfac114.001)
Stevens, K., Delles, C. , Mark, P. , Thomson, P., Gill, J. , Gray, S. , Ho, F., Rutherford, E. and Lees, J. (2022) MO468: Moving more associates with reduced risk of cardiovascular disease and death across all stages of chronic kidney disease: a UK Biobank study. Nephrology Dialysis Transplantation, 37(Sup 3), i337. (doi: 10.1093/ndt/gfac070.082)
2021
Rankin, A. J. et al. (2021) Myocardial changes on 3T cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal. Journal of Cardiovascular Magnetic Resonance, 23, 125. (doi: 10.1186/s12968-021-00822-4) (PMCID:PMC8580743)
Lees, J. S. et al. (2021) The ViKTORIES trial: a randomised, double-blind, placebo-controlled trial of vitamin K supplementation to improve vascular health in kidney transplant recipients. American Journal of Transplantation, 21(10), pp. 3356-3368. (doi: 10.1111/ajt.16566) (PMID:33742520)
Rankin, A. J. et al. (2021) Global longitudinal strain by feature tracking cardiovascular MRI predicts mortality in patients with end stage kidney disease. Clinical Kidney Journal, 14(10), pp. 2187-2196. (doi: 10.1093/ckj/sfab020)
Rutherford, E. et al. (2021) A randomized, controlled trial of the effect of allopurinol on left ventricular mass index in hemodialysis patients. Kidney International Reports, 6(1), pp. 146-155. (doi: 10.1016/j.ekir.2020.10.025) (PMID:33358501) (PMCID:PMC7590839)
2020
Witham, M. D. et al. (2020) Vitamin K supplementation to improve vascular stiffness in chronic kidney disease: the K4Kidneys randomised controlled trial. Journal of the American Society of Nephrology, 31(10), pp. 2434-2445. (doi: 10.1681/ASN.2020020225) (PMID:32817311)
Lees, J. S. , Mangion, K., Rutherford, E., Witham, M. D., Woodward, R., Roditi, G., Hopkins, T., Brooksbank, K., Jardine, A. and Mark, P. B. (2020) Vitamin K for kidney transplant organ recipients: investigating vEssel stiffness (ViKTORIES): study rationale and protocol of a randomised controlled trial. Open Heart, 7, e001070. (doi: 10.1136/openhrt-2019-001070) (PMID:32675297) (PMCID:PMC7368482)
2018
Mangion, K., McDowell, K., Mark, P. B. and Rutherford, E. (2018) Characterizing cardiac involvement in chronic kidney disease using CMR—a systematic review. Current Cardiovascular Imaging Reports, 11, 2. (doi: 10.1007/s12410-018-9441-9) (PMID:29497467) (PMCID:PMC5818546)
2017
Rutherford, E., Stewart, G., Houston, J. G., Jardine, A. G. , Mark, P. B. and Struthers, A. D. (2017) An open-label dose-finding study of allopurinol to target defined reduction in urate levels in hemodialysis patients. Journal of Clinical Pharmacology, 57(11), pp. 1409-1414. (doi: 10.1002/jcph.939) (PMID:28597919)
Rutherford, E. et al. (2017) Myocardial changes in incident haemodialysis patients over 6-months: an observational cardiac magnetic resonance imaging study. Scientific Reports, 7, 13976. (doi: 10.1038/s41598-017-14481-y) (PMID:29070834) (PMCID:PMC5656609)
Rutherford, E. and Mark, P.B. (2017) What happens to the heart in chronic kidney disease? Journal of the Royal College of Physicians of Edinburgh, 47(1), pp. 76-82. (doi: 10.4997/JRCPe.2017.117) (PMID:28569289)
Graham-Brown, M. P.M. et al. (2017) Native T1 mapping: inter-study, inter-observer and inter-center reproducibility in hemodialysis patients. Journal of Cardiovascular Magnetic Resonance, 19, 21. (doi: 10.1186/s12968-017-0337-7) (PMID:28238284) (PMCID:PMC5327541)
Rutherford, E., Weir-McCall, J. R., Patel, R. K., Houston, J. G., Roditi, G., Struthers, A. D., Jardine, A. G. and Mark, P. B. (2017) Research cardiac magnetic resonance imaging in end stage renal disease - incidence, significance and implications of unexpected incidental findings. European Radiology, 27(1), pp. 315-324. (doi: 10.1007/s00330-016-4288-4) (PMID:27053260)
2016
Rutherford, E. et al. (2016) Definition of myocardial tissue abnormalities in end stage renal failure with cardiac magnetic resonance imaging using T1 mapping. Kidney International, 90(4), pp. 845-852. (doi: 10.1016/j.kint.2016.06.014)
Findlay, M. D. et al. (2016) Risk factors and outcome of stroke in renal transplant recipients. Clinical Transplantation, 30(8), pp. 918-924. (doi: 10.1111/ctr.12765) (PMID:27218240)
Rutherford, E. and Mark, P. (2016) What does STOP-IgAN tell us about how to treat IgA nephropathy? Journal of the Royal College of Physicians of Edinburgh, 46(1), pp. 23-25. (doi: 10.4997/JRCPE.2016.107)
2015
Kidder, D., Rutherford, E., Kipgen, D., Fleming, S., Geddes, C. and Stewart, G. A. (2015) Kidney biopsy findings in primary Sjögren syndrome. Nephrology Dialysis Transplantation, 30(8), pp. 1363-1369. (doi: 10.1093/ndt/gfv042) (PMID:25817222)
2014
Patel, R. K., Pennington, C., Stevens, K. K., Taylor, A., Gillis, K. , Rutherford, E., Johnston, N., Jardine, A. G. and Mark, P. B. (2014) Effect of left atrial and ventricular abnormalities on renal transplant recipient outcome—a single-center study. Transplantation Research, 3(20), (doi: 10.1186/s13737-014-0020-6)
Articles
Chen, D. C. et al. (2024) Cystatin C- and creatinine-based estimated GFR differences: prevalence and predictors in the UK Biobank. Kidney Medicine, 6(4), 100796. (doi: 10.1016/j.xkme.2024.100796) (PMID:8567244) (PMCID:PMC10986041)
Lees, J. S. , De La Mata, N. L., Sullivan, M. K. , Wyld, M. L., Rosales, B. M., Cutting, R., Hedley, J. A., Rutherford, E., Mark, P. B. and Webster, A. C. (2023) Sex differences in associations between creatinine and cystatin C-based kidney function measures with stroke and major bleeding. European Stroke Journal, 8(3), pp. 756-768. (doi: 10.1177/23969873231173282)
Mayne, K. J., Lees, J. S. , Rutherford, E., Thomson, P. C., Traynor, J. P., Dey, V. , Lang, N. N. and Mark, P. B. (2023) Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios: associations with mortality in a haemodialysis cohort. Clinical Kidney Journal, 16(3), pp. 512-520. (doi: 10.1093/ckj/sfac248) (PMID:36865003) (PMCID:PMC9972818)
Chen, D. C., Lees, J. S. , Lu, K., Scherzer, R., Rutherford, E., Mark, P. B. , Kanaya, A. M., Shlipak, M. G. and Estrella, M. M. (2023) Differential associations of cystatin C versus creatinine‐based kidney function with risks of cardiovascular event and mortality among South Asian individuals in the UK Biobank. Journal of the American Heart Association, 12(3), e027079. (doi: 10.1161/JAHA.122.027079) (PMID:36695320) (PMCID:PMC9973614)
Sullivan, M. K. et al. (2023) Potential impact of NICE guidelines on referrals from primary care to nephrology: a primary care database and prospective research study. British Journal of General Practice, 73(727), e141-e147. (doi: 10.3399/BJGP.2022.0145) (PMID:36376072) (PMCID:PMC9678375)
Mark, P. B. , Mangion, K., Rankin, A. J. , Rutherford, E., Lang, N. N. , Petrie, M. C. , Stoumpos, S. and Patel, R. K. (2022) Left ventricular dysfunction with preserved ejection fraction: the most common left ventricular disorder in chronic kidney disease patients. Clinical Kidney Journal, 15(12), pp. 2186-2199. (doi: 10.1093/ckj/sfac146) (PMID:36381379) (PMCID:PMC9664574)
Rutherford, E., Leach, J. F., Bennett, E. J.A., Rutherford, J. S., Urquhart, L., Watt, E., Allen, R. M., Wrathall, D. W., Williams, D. and Muniraju, T. M. (2022) Acute intermittent renal replacement therapy in a rural Scottish intensive care unit – a review of patient and renal outcomes. Journal of the Intensive Care Society, 23(4), pp. 503-505. (doi: 10.1177/17511437211018616)
Lees, J. S. , Rutherford, E., Stevens, K. I., Chen, D. C., Scherzer, R., Estrella, M. M., Sullivan, M. K. , Ebert, N., Mark, P. B. and Shlipak, M. G. (2022) Assessment of Cystatin C level for risk stratification in adults with chronic kidney disease. JAMA Network Open, 5(10), e2238300. (doi: 10.1001/jamanetworkopen.2022.38300) (PMID:36282503) (PMCID:PMC9597396)
Lees, J. , Rutherford, E., Stevens, K., Chen, D., Scherzer, R., Estrella, M., Sullivan, M. , Ebert, N., Mark, P. and Shlipak, M. (2022) FC077: Cystatin C testing improves risk stratification associated with chronic kidney disease without adopting age-adapted diagnostic thresholds : a UK Biobank Study. Nephrology Dialysis Transplantation, 37(Sup 3), I842-I843. (doi: 10.1093/ndt/gfac114.001)
Stevens, K., Delles, C. , Mark, P. , Thomson, P., Gill, J. , Gray, S. , Ho, F., Rutherford, E. and Lees, J. (2022) MO468: Moving more associates with reduced risk of cardiovascular disease and death across all stages of chronic kidney disease: a UK Biobank study. Nephrology Dialysis Transplantation, 37(Sup 3), i337. (doi: 10.1093/ndt/gfac070.082)
Rankin, A. J. et al. (2021) Myocardial changes on 3T cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal. Journal of Cardiovascular Magnetic Resonance, 23, 125. (doi: 10.1186/s12968-021-00822-4) (PMCID:PMC8580743)
Lees, J. S. et al. (2021) The ViKTORIES trial: a randomised, double-blind, placebo-controlled trial of vitamin K supplementation to improve vascular health in kidney transplant recipients. American Journal of Transplantation, 21(10), pp. 3356-3368. (doi: 10.1111/ajt.16566) (PMID:33742520)
Rankin, A. J. et al. (2021) Global longitudinal strain by feature tracking cardiovascular MRI predicts mortality in patients with end stage kidney disease. Clinical Kidney Journal, 14(10), pp. 2187-2196. (doi: 10.1093/ckj/sfab020)
Rutherford, E. et al. (2021) A randomized, controlled trial of the effect of allopurinol on left ventricular mass index in hemodialysis patients. Kidney International Reports, 6(1), pp. 146-155. (doi: 10.1016/j.ekir.2020.10.025) (PMID:33358501) (PMCID:PMC7590839)
Witham, M. D. et al. (2020) Vitamin K supplementation to improve vascular stiffness in chronic kidney disease: the K4Kidneys randomised controlled trial. Journal of the American Society of Nephrology, 31(10), pp. 2434-2445. (doi: 10.1681/ASN.2020020225) (PMID:32817311)
Lees, J. S. , Mangion, K., Rutherford, E., Witham, M. D., Woodward, R., Roditi, G., Hopkins, T., Brooksbank, K., Jardine, A. and Mark, P. B. (2020) Vitamin K for kidney transplant organ recipients: investigating vEssel stiffness (ViKTORIES): study rationale and protocol of a randomised controlled trial. Open Heart, 7, e001070. (doi: 10.1136/openhrt-2019-001070) (PMID:32675297) (PMCID:PMC7368482)
Mangion, K., McDowell, K., Mark, P. B. and Rutherford, E. (2018) Characterizing cardiac involvement in chronic kidney disease using CMR—a systematic review. Current Cardiovascular Imaging Reports, 11, 2. (doi: 10.1007/s12410-018-9441-9) (PMID:29497467) (PMCID:PMC5818546)
Rutherford, E., Stewart, G., Houston, J. G., Jardine, A. G. , Mark, P. B. and Struthers, A. D. (2017) An open-label dose-finding study of allopurinol to target defined reduction in urate levels in hemodialysis patients. Journal of Clinical Pharmacology, 57(11), pp. 1409-1414. (doi: 10.1002/jcph.939) (PMID:28597919)
Rutherford, E. et al. (2017) Myocardial changes in incident haemodialysis patients over 6-months: an observational cardiac magnetic resonance imaging study. Scientific Reports, 7, 13976. (doi: 10.1038/s41598-017-14481-y) (PMID:29070834) (PMCID:PMC5656609)
Rutherford, E. and Mark, P.B. (2017) What happens to the heart in chronic kidney disease? Journal of the Royal College of Physicians of Edinburgh, 47(1), pp. 76-82. (doi: 10.4997/JRCPe.2017.117) (PMID:28569289)
Graham-Brown, M. P.M. et al. (2017) Native T1 mapping: inter-study, inter-observer and inter-center reproducibility in hemodialysis patients. Journal of Cardiovascular Magnetic Resonance, 19, 21. (doi: 10.1186/s12968-017-0337-7) (PMID:28238284) (PMCID:PMC5327541)
Rutherford, E., Weir-McCall, J. R., Patel, R. K., Houston, J. G., Roditi, G., Struthers, A. D., Jardine, A. G. and Mark, P. B. (2017) Research cardiac magnetic resonance imaging in end stage renal disease - incidence, significance and implications of unexpected incidental findings. European Radiology, 27(1), pp. 315-324. (doi: 10.1007/s00330-016-4288-4) (PMID:27053260)
Rutherford, E. et al. (2016) Definition of myocardial tissue abnormalities in end stage renal failure with cardiac magnetic resonance imaging using T1 mapping. Kidney International, 90(4), pp. 845-852. (doi: 10.1016/j.kint.2016.06.014)
Findlay, M. D. et al. (2016) Risk factors and outcome of stroke in renal transplant recipients. Clinical Transplantation, 30(8), pp. 918-924. (doi: 10.1111/ctr.12765) (PMID:27218240)
Rutherford, E. and Mark, P. (2016) What does STOP-IgAN tell us about how to treat IgA nephropathy? Journal of the Royal College of Physicians of Edinburgh, 46(1), pp. 23-25. (doi: 10.4997/JRCPE.2016.107)
Kidder, D., Rutherford, E., Kipgen, D., Fleming, S., Geddes, C. and Stewart, G. A. (2015) Kidney biopsy findings in primary Sjögren syndrome. Nephrology Dialysis Transplantation, 30(8), pp. 1363-1369. (doi: 10.1093/ndt/gfv042) (PMID:25817222)
Patel, R. K., Pennington, C., Stevens, K. K., Taylor, A., Gillis, K. , Rutherford, E., Johnston, N., Jardine, A. G. and Mark, P. B. (2014) Effect of left atrial and ventricular abnormalities on renal transplant recipient outcome—a single-center study. Transplantation Research, 3(20), (doi: 10.1186/s13737-014-0020-6)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Non-invasively quantifying, understanding and reversing myocardial fibrosis in renal failure
Chief Scientist Office
2018 - 2021
- Vitamin K in Transplanted Kidney Organ Recipients: Investigating vEssel Stiffness (ViKTORIES)
Kidney Research UK
2017 - 2019