Dr Dilys Freeman

Honorary Senior Lecturer (School of Cardiovascular & Metabolic Health)

Biography

After studying Biochemistry at the University of Edinburgh, Dr Dilys Freeman undertook her PhD in industry at Glaxo Group Research in Middlesex. Postdoctoral positions in Glasgow and the University of Texas Southwestern Medical Center at Dallas were followed by her first academic appointment in Biological Science at the University of Durham. Dilys joined the University of Glasgow in 1999. Dr Freeman's early research was in the field of cardiovascular disease in particular lipid and lipoprotein metabolism. She studied cholesteryl ester transfer protein and its role in high density lipoprotein metabolism as well as the genetic regulation of plasma high density lipoprotein and low density lipoprotein levels. Dilys has been involved in the analysis of the West of Scotland Coronary Prevention Study (WOSCOPS), in particular the influence of inflammation, statins and genetics on the aetiology of type 2 diabetes. Her current research is in the field of metabolism in diabetes and also in pregnancy.

Research interests

Research Theme: Metabolic Disease

My current research predominantly focuses on metabolism in pregnancy and its vascular complications such as preeclampsia, gestational diabetes mellitus and growth restriction. The focus is on lipid and carbohydrate metabolism and inflammation in obese pregnancy and the role of vascular function, the adipocyte and ectopic fat in the development of adverse pregnancy outcome. The metabolic cross-talk between mother and baby, its regulation by the placenta and long term disease implications for the offspring are also of interest.

Research on type 2 diabetes involves exploring the links between adipose tissue expandability and ectopic fat accumulation. I am involved in studies comparing how adipose tissue from Europeans and South Asians adapts to weight gain and weight loss and in studies looking at how muscle stores triglyceride in insulin resistant states.

Research groups

Publications

List by: Type | Date

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Number of items: 82.

2024

Beazer, J. D. et al. (2024) Favourable HDL composition in endurance athletes is not associated with changes in HDL in vitro antioxidant and endothelial anti-inflammatory function. Bioscience Reports, (doi: 10.1042/BSR20241165) (PMID:39344511) (Early Online Publication)

McLaren, J., Gao, X., Ghouri, N. , Freeman, D. J. , Richardson, J. , Sattar, N. and Gill, J. M.R. (2024) Weight gain leads to greater adverse metabolic responses in South Asian compared with white European men: the GlasVEGAS study. Nature Metabolism, 6(8), pp. 1632-1645. (doi: 10.1038/s42255-024-01101-z) (PMID:39152223) (PMCID:PMC11349579) (Early Online Publication)

2023

Irshad, Z. et al. (2023) The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background. FASEB Journal, 37(11), e23209. (doi: 10.1096/fj.202300960RR) (PMID:37779421)

Meyer, B. J., Cortie, C., Dekker-Nitert, M., Barrett, H. L. and Freeman, D. J. (2023) Women with gestational diabetes mellitus, controlled for plasma glucose level, exhibit maternal and fetal dyslipidaemia that may warrant treatment. Diabetes Research and Clinical Practice, 204, 110929. (doi: 10.1016/j.diabres.2023.110929) (PMID:37783345)

2022

Beazer, J. D. and Freeman, D. J. (2022) Estradiol and HDL function in women – a partnership for life. Journal of Clinical Endocrinology and Metabolism, 107(5), e2192-2194. (doi: 10.1210/clinem/dgab811) (PMID:34788853) (PMCID:PMC9016454)

2021

Trivett, C., Lees, Z. J. and Freeman, D. J. (2021) Adipose tissue function in healthy pregnancy, gestational diabetes mellitus and pre-eclampsia. European Journal of Clinical Nutrition, 75(12), pp. 1745-1756. (doi: 10.1038/s41430-021-00948-9) (PMID:34131300)

Patanapirunhakit, P., Karlsson, H., Mulder, M., Ljunggren, S., Graham, D. and Freeman, D. (2021) Sphingolipids in HDL – potential markers for adaptation to pregnancy? Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids, 1866(8), 158955. (doi: 10.1016/j.bbalip.2021.158955) (PMID:33933650)

2020

Zamai, N., Cortie, C. H., Jarvie, E. M., Onyiaodike, C. C., Alrehaili, A., Francois, M., Freeman, D. J. and Meyer, B. J. (2020) In pregnancy, maternal HDL is specifically enriched in, and carries the highest proportion of, DHA in plasma. Prostaglandins, Leukotrienes and Essential Fatty Acids, 163, 102209. (doi: 10.1016/j.plefa.2020.102209)

Beazer, J. D. , Patanapirunhakit, P., Gill, J. M.R. , Graham, D. , Karlsson, H., Ljunggren, S., Mulder, M. and Freeman, D. J. (2020) High-density lipoprotein’s vascular protective functions in metabolic and cardiovascular disease - could extracellular vesicles be at play? Clinical Science, 134(22), pp. 2977-2986. (doi: 10.1042/CS20200892) (PMID:33210708)

Jarvie, E., Stewart, F., Ramsay, J. E., Brown, E. A., Meyer, B., Olivecrona, G., Griffin, B. and Freeman, D. (2020) Maternal adipose tissue expansion, a missing link in the prediction of birth weight centile. Journal of Clinical Endocrinology and Metabolism, 105(3), e814-e825. (doi: 10.1210/clinem/dgz248) (PMID:31832635)

2019

Bagot, C.N., Leishman, E., Onyiaodike, C.C., Jordan, F., Gibson, V.B. and Freeman, D.J. (2019) Changes in laboratory markers of thrombotic risk early in the first trimester of pregnancy may be linked to an increase in estradiol and progesterone. Thrombosis Research, 178, pp. 47-53. (doi: 10.1016/j.thromres.2019.03.015) (PMID:30965151)

Logue, J. , Sattar, N. and Freeman, D. (2019) Obesity. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 419-427. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_39)

2018

Chavan-Gautam, P., Rani, A. and Freeman, D. J. (2018) Distribution of fatty acids and lipids during pregnancy. In: Makowski, G. S. (ed.) Advances in Clinical Chemistry. Elsevier, pp. 209-239. (doi: 10.1016/bs.acc.2017.12.006)

Onyiaodike, C. C. et al. (2018) Pre-conception maternal erythrocyte saturated to unsaturated fatty acid ratio predicts pregnancy after natural cycle frozen embryo transfer. Scientific Reports, 8, 1216. (doi: 10.1038/s41598-018-19500-0) (PMID:29352147) (PMCID:PMC5775249)

2017

Jayabalan, N. et al. (2017) Cross talk between adipose tissue and placenta in obese and gestational diabetes mellitus pregnancies via exosomes. Frontiers in Endocrinology, 8, 239. (doi: 10.3389/fendo.2017.00239)

Bagot, C.N., Leishman, E., Onyiaodike, C.C., Jordan, F. and Freeman, D.J. (2017) Normal pregnancy is associated with an increase in thrombin generation from the very early stages of the first trimester. Thrombosis Research, 157, pp. 49-54. (doi: 10.1016/j.thromres.2017.06.027) (PMID:28692840)

Gao, X., Salomon, C. and Freeman, D. J. (2017) Extracellular vesicles from adipose tissue - a potential role in obesity and type 2 diabetes? Frontiers in Endocrinology, 8, 202. (doi: 10.3389/fendo.2017.00202)

Huda, S. S., Jordan, F., Bray, J., Love, G., Payne, R., Sattar, N. and Freeman, D. J. (2017) Visceral adipose tissue activated macrophage content and inflammatory adipokine secretion is higher in pre-eclampsia than in healthy pregnancy. Clinical Science, 131(13), pp. 1529-1540. (doi: 10.1042/CS20160832) (PMID:28566469) (PMCID:PMC6376613)

Meyer, B. J. and Freeman, D. J. (2017) Maternal plasma docosahexaenoic acid (DHA) concentrations increase at the critical time of neural tube closure. Fats of Life,

Small, H. Y., Akehurst, C., Sharafetdinova, L., McBride, M. W. , McClure, J. D. , Robinson, S. W., Carty, D. M., Freeman, D. J. and Delles, C. (2017) HLA gene expression is altered in whole blood and placenta from women who later developed preeclampsia. Physiological Genomics, 49(3), pp. 193-200. (doi: 10.1152/physiolgenomics.00106.2016) (PMID:28130428) (PMCID:PMC5374453)

Freeman, D. J. and Meyer, B. J. (2017) Brain food for babies. Biochemist, 39(1), pp. 26-29.

2016

Brown, S. H.J., Eather, S. R., Freeman, D. J. , Meyer, B. J. and Mitchell, T. W. (2016) A lipidomic analysis of placenta in preeclampsia: evidence for lipid storage. PLoS ONE, 11(9), e0163972. (doi: 10.1371/journal.pone.0163972) (PMID:27685997) (PMCID:PMC5042456)

Wan Sulaiman, W.N., Caslake, M.J., Delles, C. , Karlsson, H., Mulder, M.T., Graham, D. and Freeman, D.J. (2016) Does high-density lipoprotein protect vascular function in healthy pregnancy? Clinical Science, 130(7), pp. 491-497. (doi: 10.1042/cs20150475) (PMID:26888561)

Meyer, B. J., Onyiaodike, C. C., Brown, E. A., Jordan, F., Murray, H., Nibbs, R. J. B. , Sattar, N. , Lyall, H., Nelson, S. M. and Freeman, D. J. (2016) Maternal plasma DHA levels increase prior to 29 days post-LH surge in women undergoing frozen embryo transfer: a prospective, observational study of human pregnancy. Journal of Clinical Endocrinology and Metabolism, 101(4), pp. 1745-1753. (doi: 10.1210/jc.2015-3089) (PMID:26895389)

2015

Akehurst, C. et al. (2015) Differential expression of microRNA-206 and its target genes in pre-eclampsia. Journal of Hypertension, 33(10), pp. 2068-2074. (doi: 10.1097/HJH.0000000000000656) (PMID:26213997) (PMCID:PMC4570688)

Escola-Gil, J.C., Julve, J., Griffin, B.A., Freeman, D.J. and Blanco-Vaca, F. (2015) HDL and lifestyle interventions. In: von Eckardstein, A. and Kardassis, D. (eds.) High Density Lipoproteins: From Biological Understanding to Clinical Exploitation. Series: Handbook of experimental pharmacology (224). Springer Open: Cham, pp. 569-592. ISBN 9783319096650 (doi: 10.1007/978-3-319-09665-0_18)

2014

Lawlor, D. A., West, J., Fairley, L., Nelson, S. M. , Bhopal, R. S., Tuffnell, D., Freeman, D. J. , Wright, J., Whitelaw, D. C. and Sattar, N. (2014) Pregnancy glycaemia and cord-blood levels of insulin and leptin in Pakistani and white British mother–offspring pairs: findings from a prospective pregnancy cohort. Diabetologia, 57(12), pp. 2492-2500. (doi: 10.1007/s00125-014-3386-6)

Huda, S. S., Forrest, R., Paterson, N., Jordan, F., Sattar, N. and Freeman, D. J. (2014) In preeclampsia, maternal third trimester subcutaneous adipocyte lipolysis is more resistant to suppression by insulin than in healthy pregnancy. Hypertension, 63(5), pp. 1094-1101. (doi: 10.1161/HYPERTENSIONAHA.113.01824) (PMID:24591340)

2013

McKenna, L., Huda, S., Freeman, D. and Jarvie, E. (2013) How to assess and manage hypertension during and after pregnancy. Clinical Practice, 10(4), pp. 455-470. (doi: 10.2217/CPR.13.34)

Meyer, B.J., Stewart, F.M., Brown, E.A., Cooney, J., Nilsson, S., Olivecrona, G., Ramsay, J.E., Griffin, B.A., Caslake, M.J. and Freeman, D.J. (2013) Maternal obesity is associated with the formation of small dense LDL and hypoadiponectinemia in the third trimester. Journal of Clinical Endocrinology and Metabolism, 98(2), pp. 643-652. (doi: 10.1210/jc.2012-3481)

Hodson, L., Neville, M., Chong, M.F.-F., Rogers, I., Huda, S.S., Freeman, D.J. , Frayn, K.N. and Fielding, B.A. (2013) Micro-techniques for analysis of human adipose tissue fatty acid composition in dietary studies. Nutrition, Metabolism and Cardiovascular Diseases, 23(11), pp. 1128-1133. (doi: 10.1016/j.numecd.2012.11.003)

2012

MacKenzie, R.M., Sandrim, V.C., Carty, D.M., McClure, J.D. , Freeman, D.J. , Dominiczak, A.F. , McBride, M.W. and Delles, C. (2012) Endothelial FOS expression and pre-eclampsia. BJOG: An International Journal of Obstetrics and Gynaecology, 119(13), pp. 1564-1571. (doi: 10.1111/1471-0528.12016)

Carty, D.M., Anderson, L.A., Freeman, D.J. , Welsh, P.I. , Brennand, J.E., Dominiczak, A.F. and Delles, C. (2012) Early pregnancy soluble E-selectin concentrations and risk of preeclampsia. Journal of Hypertension, 30(5), pp. 954-959. (doi: 10.1097/HJH.0b013e328352573b)

Bernini, F. et al. (2012) European lipoprotein club: report of the 34th ELC annual conference, Tutzing, 5–8 September 2011. Atherosclerosis, 221(1), pp. 287-293. (doi: 10.1016/j.atherosclerosis.2011.12.002)

Mackay, V.A. et al. (2012) Preeclampsia is associated with compromized maternal synthesis of long chain polyunsaturated fatty acids leading to offspring deficiency. Hypertension, 60(4), pp. 1078-1085. (doi: 10.1161/HYPERTENSIONAHA.112.197897)

Sattar, N. and Freeman, D.J. (2012) Potential mechanisms contributing to gestational diabetes and pre-eclampsia in the obese woman. In: Gillman, M.W. and Poston, L. (eds.) Maternal Obesity. Series: Cambridge medicine. Cambridge University Press: Cambridge, UK, pp. 45-55. ISBN 978107003965 (doi: 10.1017/CBO9780511782466)

Sattar, N. and Freeman, D.J. (2012) Potential mechanisms contributing to gestational diabetes and preeclampsia in the obese woman. In: Gillman, M.W. and Poston, L. (eds.) Maternal Obesity. Cambridge University Press. ISBN 9781107003965

2011

Bernini, F., Fisher, R., Freeman, D.J. , Groen, A., Kalopissis, A., Malle, E., Mulder, M., Niemeier, A., Parini, P. and Hansen, A.T. (2011) Report of the 33rd Annual Conference of the European Lipoprotein Club, Tutzing, 6–9 September 2010. Atherosclerosis, 215(1), pp. 249-255. (doi: 10.1016/j.atherosclerosis.2010.12.002)

Freeman, D. J. et al. (2011) Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). BMC Geriatrics, 11, 8. (doi: 10.1186/1471-2318-11-8) (PMID:21342490) (PMCID:PMC3053238)

2010

Sattar, N. et al. (2010) Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet, 375(9716), pp. 735-742. (doi: 10.1016/S0140-6736(09)61965-6)

Fisher, R. et al. (2010) European Lipoprotein Club: Report of the 32nd ELC Annual Conference, Tutzing, 7–10 September 2009. Atherosclerosis, 210(2), pp. 680-686. (doi: 10.1016/j.atherosclerosis.2009.12.038)

Freeman, D.J. (2010) Effects of maternal obesity on fetal growth and body composition: implications for programming and future health. Seminars in Fetal and Neonatal Medicine, 15(2), pp. 113-118. (doi: 10.1016/j.siny.2009.09.001)

Freeman, D.J. and Sattar, N. (2010) The effect of pregnancy on energy metabolism, body composition and endothelial function. In: Tsatsoulis, A., Wyckoff, J. and Brown, F.M. (eds.) Diabetes in Women. Series: Contemporary diabetes. Humana Press Inc., pp. 207-222. ISBN 9781603272506 (doi: 10.1007/978-1-60327-250-6_11)

Jarvie, E., Hauguel‑de‑Mouzon, S., Nelson, S.M. , Sattar, N. , Catalano, P.M. and Freeman, D.J. (2010) Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring. Clinical Science, 119(3), pp. 123-129. (doi: 10.1042/CS20090640)

Madigan, J. et al. (2010) Chemokine Scavenger D6 Is Expressed by Trophoblasts and Aids the Survival of Mouse Embryos Transferred into Allogeneic Recipients. Journal of Immunology, 184(6), pp. 3202-3212. (doi: 10.4049/jimmunol.0902118)

Nelson, S. M. , Stewart, F., Fleming, R. and Freeman, D. J. (2010) Longitudinal assessment of antimullerian hormone during pregnancy-relationship with maternal adiposity, insulin, and adiponectin. Fertility and Sterility, 93(4), pp. 1356-1358. (doi: 10.1016/j.fertnstert.2009.07.1676)

Sofat, R. et al. (2010) Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. Circulation, 121(1), pp. 52-62. (doi: 10.1161/CIRCULATIONAHA.109.865444)

2009

Bernini, F. et al. (2009) European Lipoprotein Club: Report of the 31st ELC Annual Conference, Tutzing, 8–11 September 20. Atherosclerosis, 205(1), pp. 41-47. (doi: 10.1016/j.atherosclerosis.2008.12.003)

Huda, S.S., Freeman, D.J. and Nelson, S.M. (2009) Short and long term strategies for the management of hypertensive disorders of pregnancy. Expert Review of Cardiovascular Therapy, 7(12), pp. 1581-1594. (doi: 10.1586/erc.09.147)

Huda, S., Sattar, N. and Freeman, D. (2009) Lipoprotein metabolism and vascular complications in pregnancy. Clinical Lipidology, 4(1), pp. 91-102.

Kanagalingam, M.G., Nelson, S., Freeman, D., Ferrell, W.R., Cherry, L.M., Lowe, G.D.O., Greer, I.A. and Sattar, N.A. (2009) Vascular dysfunction and alteration of novel and classic cardiovascular risk factors in mothers of growth restricted offspring. Atherosclerosis, 205(1), pp. 244-250. (doi: 10.1016/j.atherosclerosis.2008.10.006)

Nelson, S., Freeman, D., Sattar, N. and Lindsay, R. (2009) Erythrocytosis in offspring of mothers with Type 1 diabetes-are factors other than insulin critical determinants? Diabetic Medicine, 26(9), pp. 887-892. (doi: 10.1111/j.1464-5491.2009.02797.x)

Sattar, N. et al. (2009) Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly. Diabetologia, 52(2), pp. 235-239.

2008

Maclntyre, A., Brouilette, S.W., Lamb, K., Radhakrishnan, K., McGlynn, L.M., Chee, M.M., Parkinson, E.K., Freeman, D., Madhok, R. and Shiels, P.G. (2008) Association of increased telomere lengths in limited scleroderma, with a lack of age-related telomere erosion. Annals of the Rheumatic Diseases, 67(12), pp. 1780-1782. (doi: 10.1136/ard.2007.086652)

Sattar, N. et al. (2008) Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies. Lancet, 371(9628), pp. 1927-1935. (doi: 10.1016/S0140-6736(08)60602-9)

Freeman, D., Tham, K., Brown, E., Rumley, A., Lowe, G. and Greer, I. (2008) Placental corticotrophin-releasing hormone RNA and microparticles in maternal plasma are not measures of placental shedding of debris: reply to a rebuttal. Journal of Thrombosis and Haemostasis, 6(10), pp. 1838-1839.

Freeman, D., Tham, K., Brown, E., Rumley, A., Lowe, G. and Greer, I. (2008) Fetal corticotrophin-releasing hormone mRNA, but not phosphatidylserine-exposing microparticles, in maternal plasma are associated with factor VII activity in pre-eclampsia. Journal of Thrombosis and Haemostasis, 6(3), pp. 421-427. (doi: 10.1111/j.1538-7836.2007.02882.x)

Hofker, M. et al. (2008) European Lipoprotein Club: Report of the 30th ELC annual conference, Tutzing, 3–6 Septem. Atherosclerosis, 197(1), pp. 471-479. (doi: 10.1016/j.atherosclerosis.2007.12.022)

Meyer, B. and Freeman, D. (2008) Role of omega-3 polyunsaturated fatty acids in pregnancy: need for increasing awareness among women. Agro Food Industry Hi-Tech, 19(4), pp. 17-19.

Nelson, S., Freeman, D.J. , Sattar, N. and Lindsay, R.S. (2008) Role of adiponectin in matching of fetal and placental weight in mothers with type 1 diabetes. Diabetes Care, 31(6), pp. 1123-1125. (doi: 10.2337/dc07-2195)

2007

Stewart, F.M., Freeman, D.J. , Ramsay, J.E., Greer, I.A., Caslake, M. and Ferrell, W.R. (2007) Longitudinal assessment of maternal endothelial function and markers of inflammation and placental function throughout pregnancy in lean and obese mothers. Journal of Clinical Endocrinology and Metabolism, 92(3), pp. 969-975. (doi: 10.1210/jc.2006-2083)

Freeman, D. (2007) Genetic factors in vascular disease. In: Greer, I.A., Ginsberg, J. and Forbes, C.D. (eds.) Women's Vascular Health. Hodder Arnold: London, pp. 52-60. ISBN 100340809973

Nelson, S., Freeman, D., Lindsay, R.S. and Sattar, N. (2007) Preeclampsia and screening for cardiovascular disease. BMJ Rapid Response,

Nelson, S.M., Freeman, D.J., Sattar, N., Johnstone, F.D. and Lindsay, R.S. (2007) IGF-1 and leptin associate with fetal HDL cholesterol at birth: Examination in offspring of mothers with type 1 diabetes. Diabetes, 56, pp. 2705-2709. (doi: 10.2337/db07-0585)

Nelson, S., Sattar, N., Freeman, D., Walker, J. and Lindsay, R. (2007) Inflammation and endothelial activation is evident at birth in offspring of mothers with type 1 diabetes. Diabetes, 56, pp. 2697-2704. (doi: 10.2337/db07-0662)

Stewart, F., Rodie, V., Ramsay, J., Greer, I., Freeman, D. and Meyer, B. (2007) Longitudinal assessment of erythrocyte fatty acid composition throughout pregnancy and post partum. Lipids, 42, pp. 335-344. (doi: 10.1007/s11745-006-3005-5)

2006

Freeman, D. (2006) Update on gestational hypertension. Women's Health, 2(5), pp. 695-698.

2005

Boekholdt, S. et al. (2005) Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment - Individual patient meta-analysis of 13,677 subjects. Circulation, 111, pp. 278-287. (doi: 10.1161/01.CIR.0000153341.46271.40)

Rodie, V., Young, A., Jordan, F., Sattar, N. , Greer, I. and Freeman, D. (2005) Human placental peroxisome proliferator-activated receptor delta and gamma expression in healthy pregnancy and in preeclampsia and intrauterine growth restriction. Journal of the Society For Gynecologic Investigation, 12, pp. 320-329. (doi: 10.1016/j.jsgi.2005.03.004)

2004

Freeman, D., McManus, F., Brown, E., Cherry, L., Norrie, J., Ramsay, J., Clark, P., Walker, I., Sattar, N. and Greer, I. (2004) Short- and long-term changes in plasma inflammatory markers associated with preeclampsia. Hypertension, 44, pp. 708-714. (doi: 10.1161/01.HYP.0000143849.67254.ca)

Rodie, V., Caslake, M., Stewart, F., Sattar, N., Ramsay, J., Greer, I. and Freeman, D. (2004) Fetal cord plasma lipoprotein status in uncomplicated human pregnancies and in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. Atherosclerosis, 176, pp. 181-187. (doi: 10.1016/j.atherosclerosis.2004.04.026)

Rodie, V., Freeman, D., Sattar, N. and Greer, I. (2004) Pre-eclampsia and cardiovascular disease: metabolic syndrome of pregnancy? Atherosclerosis, 175, pp. 189-202. (doi: 10.1016/j.atherosclerosis.2004.01.038)

Shepherd, J. et al. (2004) CHD and diabetes reversing the trend. Doctor, Supple, pp. 1-8.

2003

Clark, P., Freeman, D., Streja, E., Sattar, N., Walker, I. and Greer, I. (2003) The G-to-T point mutation in codon 34 of the factor XIII gene and the risk of pre-eclampsia. Blood Coagulation and Fibrinolysis, 14, pp. 155-157. (doi: 10.1097/01.mbc.0000046189.72384.5a)

Freeman, D., Samani, N., Wilson, V., McMahon, A., Braund, P., Cheng, S., Caslake, M., Packard, C. and Gaffney, D. (2003) A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study. European Heart Journal, 24, pp. 1833-1842. (doi: 10.1016/j.ehj.2003.07.001)

Shepherd, A. et al. (2003) Stroke prevention in primary care. Doctor, Supple, pp. 1-8.

Shepherd, J. et al. (2003) Obesity, metabolic syndrome and cardiovascular risk. Doctor, Supple, pp. 1-8.

2002

Freeman, D.J. , Norrie, J., Caslake, M.J., Gaw, A., Ford, I. , Lowe, G.D.O., O'Reilly, D. S. J.,, Packard, C.J. and Sattar, N. (2002) C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes, 51(5), pp. 1596-1600. (doi: 10.2337/diabetes.51.5.1596)

Freeman, D.J. , Norrie, J., Caslake, M.J., Gaw, A., Ford, I. , Lowe, G.D.O., O'Reilly, D.S., Packard, C.J. and Sattar, N. (2002) C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study. Diabetes, 51(5), pp. 1596-1600.

Shepherd, J.S. et al. (2002) Pragmatic coronary prevention, identifying patients at high risk of coronary heart disease. British Journal of Cardiology, 9(4), S1-S15.

2001

Freeman, D. et al. (2001) Pravastatin and the development of diabetes mellitus - Evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study. Circulation, 103(3), pp. 357-362.

This list was generated on Wed Nov 20 21:54:19 2024 GMT.

Jump to: Articles | Book Sections

Number of items: 82.

Articles

Meyer, B. J. and Freeman, D. J. (2017) Maternal plasma docosahexaenoic acid (DHA) concentrations increase at the critical time of neural tube closure. Fats of Life,

Freeman, D. J. and Meyer, B. J. (2017) Brain food for babies. Biochemist, 39(1), pp. 26-29.

McKenna, L., Huda, S., Freeman, D. and Jarvie, E. (2013) How to assess and manage hypertension during and after pregnancy. Clinical Practice, 10(4), pp. 455-470. (doi: 10.2217/CPR.13.34)

Sattar, N. et al. (2010) Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet, 375(9716), pp. 735-742. (doi: 10.1016/S0140-6736(09)61965-6)

Huda, S., Sattar, N. and Freeman, D. (2009) Lipoprotein metabolism and vascular complications in pregnancy. Clinical Lipidology, 4(1), pp. 91-102.

Meyer, B. and Freeman, D. (2008) Role of omega-3 polyunsaturated fatty acids in pregnancy: need for increasing awareness among women. Agro Food Industry Hi-Tech, 19(4), pp. 17-19.

Nelson, S., Freeman, D., Lindsay, R.S. and Sattar, N. (2007) Preeclampsia and screening for cardiovascular disease. BMJ Rapid Response,

Freeman, D. (2006) Update on gestational hypertension. Women's Health, 2(5), pp. 695-698.

Shepherd, J. et al. (2004) CHD and diabetes reversing the trend. Doctor, Supple, pp. 1-8.

Shepherd, A. et al. (2003) Stroke prevention in primary care. Doctor, Supple, pp. 1-8.

Shepherd, J. et al. (2003) Obesity, metabolic syndrome and cardiovascular risk. Doctor, Supple, pp. 1-8.

Shepherd, J.S. et al. (2002) Pragmatic coronary prevention, identifying patients at high risk of coronary heart disease. British Journal of Cardiology, 9(4), S1-S15.

Book Sections

Freeman, D. (2007) Genetic factors in vascular disease. In: Greer, I.A., Ginsberg, J. and Forbes, C.D. (eds.) Women's Vascular Health. Hodder Arnold: London, pp. 52-60. ISBN 100340809973

This list was generated on Wed Nov 20 21:54:19 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

HDL composition and structure in insulin resistance
NHS Greater Glasgow and Clyde Endowment Funds
2023 - 2024
Adipose tissue immunometabolic function in viscerally obese individuals at risk of poor ICU outcome in sepsis
NHS Greater Glasgow and Clyde Endowment Funds
2023 - 2024
Assessment of the Prothrombotic Effect of Obesity during Pregnancy
British Heart Foundation
2019 - 2021
Vaso-protective properties of maternal high density lipoprotein (HDL) in metabolic complications of pregnancy
NHS Greater Glasgow and Clyde Endowment Funds
2018 - 2019
Role of alternative pathway of triglyceride synthesis in determining insulin sensitivity in muscle of individuals at risk of type 2 diabetes
Diabetes UK
2016 - 2019
IL-33 as an Immune Regulator in Pregnancy
Tenovus Scotland
2014 - 2015
EMIF
European Commission
2013 - 2017
Early pregnancy mobilisation of fatty acids
The Carnegie Trust for the Universities of Scotland
2010 - 2011
Maternal lipotoxic response in obese pregnancy
Wellbeing of Women
2010 - 2012
The intrauterine environment and differences in adiposity and insulin resistance between South Asian and European populations
British Heart Foundation
2009 - 2011
Early pregnancy metabolic and inflammatory changes and their relationship to successful pregnancy
Wellbeing of Women
2007 - 2010
Risk factors for the development of incident thrombotic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER)
Chest Heart and Stroke Scotland
2005 - 2006
An investigation of the role of the chemokine receptor D6 in placental dysfunction
Scottish Hospital Endowments Research Trust
2005 - 2007
Adipocyte lipolysis as a candidate pathway in the pathogenesis of pre-eclampsia
British Heart Foundation
2004 - 2008
Maternal and fetal dyslipidaemia in polycystic ovarian syndrome pregnancy
The Future Forum
2004 - 2005
Longitudinal assessment of vascular function throughout pregnancy and the puerperium - relationship of maternal body fat distribution to...
British Medical Association
2003 - 2006
Does low birth weight pregnancy signal markedly increased maternal cardiovascular risk
Chest Heart and Stroke Scotland
2003 - 2004
Lipocortin 1 - modulation of molecular mechanisms of inflammation in atherosclerosis
British Heart Foundation
2003 - 2005
Is there a link between inflammation and insulin resistance in pre-eclampsia?
Scottish Executive Health Department
2003 - 2004

Supervision

Olivera, Sol
The impact of preeclampsia on offspring nutrition, metabolism and cardiovascular function

Teaching

Programme Director MSc Diabetes

Women's and Children's Health Specialist Course Co-Ordinator, Intercalated BSc.

Research datasets

Jump to: 2019 | 2017

Number of items: 2.

2019

Jarvie, E., Stewart, F. M., Ramsay, J. E., Brown, E. A., Meyer, B. J., Olivecrona, G., Griffin, B. A. and Freeman, D. (2019) Maternal adipose tissue expansion, a missing link in the prediction of birth weight centile. [Data Collection]

2017

Onyiaodike, C. C., Murray, H., Zhang, Z., Meyer, B. J., Jordan, F., Brown, E. A., Nibbs, R. , Lyall, H., Sattar, N. , Nelson, S. and Freeman, D. (2017) Pre-conception maternal erythrocyte saturated to unsaturated fatty acid ratio predicts pregnancy after natural cycle frozen embryo transfer. [Data Collection]

This list was generated on Thu Nov 21 03:34:02 2024 GMT.

Additional information

Editorial Board

2014 - present: Pediatric Obesity - Associate Editor
2008 - present: Clinical Science - Editorial Board and Associate Editor
2000 - 2007: Atherosclerosis - Associate Editor

Invited International Presentations

2014: Association for the Study of Obesity (ASO) - Organising committee and keynote speaker
2013: International Association for the Study of Obesity (IASO) - Organising committee and keynote speaker
2012: HDLnet COST action BM0904 Meeting - Invited speaker
2011: New Zealand Maternal Fetal Medicine Network - Keynote speaker
2011: American Diabetes Association - Keynote speaker
2011: American Diabetes Association - Keynote speaker
2011: Australian Diabetes in Pregnancy Society (ADIPS) - Keynote speaker
2010: International Association of the Diabetes and Pregnancy Study Groups (IADPSG) - Keynote speaker
2008: International Society for the Study of Hypertension in Pregnancy (ISSHP) - Keynote speaker

Professional Learned Society

2014 - 2015: UKCO 2015 - Organising Committee
2014 - present: Yorkhill Children's Charity - Steering Committee
2014 - 2015: International Association for the Study of Obesity - Organising Committee
2013 - present: Association for the Study of Obesity - Treasurer
2013 - present: University of Wollongong, Australia - Visiting Principal Fellow
2012 - present: NHSGGC - Member of the NHSGGC Research Endowments Committee
2011 - present: BM0904 - Management committee member (BM0904) EU COST action
2008 - present: University of Wollongong, Australia - Visiting Senior Fellow
2007 - 2011: European Lipoprotein Club - Treasurer

Dr Dilys Freeman

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Dr Dilys Freeman

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Additional information

Editorial Board

Invited International Presentations

Professional Learned Society