Professor Christopher Loughrey

  • Professor of Experimental Cardiology (Cardiovascular & Metabolic Health)
  • Head of School, Biodiversity, One Health and Veterinary Medicine (Biodiversity, One Health & Veterinary Medicine Professional Services)

telephone: 01413302753
email: Christopher.Loughrey@glasgow.ac.uk

Prof. Christopher M. Loughrey, University of Glasgow, Glasgow Cardiovascular Research Centre, 126 University Place, Glasgow, G12 8TA

Import to contacts

ORCID iDhttps://orcid.org/0000-0003-1297-9159

Biography

Christopher qualified as a veterinary surgeon in 2000 and gained his PhD in 2003. Since 2005, his research group has focused on using novel animal models to advance our understanding of human cardiac disease including the molecular mechanisms associated with heart failure and myocardial infarction – the leading cause of death globally. Christopher’s research provides important insights into how early perturbations of gene expression fundamentally affect adverse cardiac remodelling. This work not only expands the boundaries of our basic scientific knowledge in cardiomyocyte biology but demonstrates that therapeutic interventions applied early following disease have the potential to change the entire trajectory of patient outcome over time.

Christopher is a Principal Investigator on a British Heart Foundation (BHF) programme grant and has held a number of project grants funded by the Medical Research Council, BHF, Heart Research UK, Medical Research Scotland and Chief Scientist Office. He is currently the Executive Deputy Editor of Cardiovascular Research and has served on the Editorial board of the British Journal of Pharmacology and Frontiers in Physiology; Cardiac Electrophysiology. Christopher is an appointed member of the Royal College of Veterinary Surgeons (RCVS) Council, Honorary Professor at the University of Sydney, Fellow of the Royal Society of Biology and an elected Fellow of the RCVS.

Christopher was International Dean between 2018-2024 and implemented an international partnership strategy across the College of Medical, Veterinary and Life Sciences that continues to contribute to the University of Glasgow’s vibrant international student population, cultural diversity and global connections. As the current Head of the School of Biodiversity, One Health and Veterinary Medicine (2023-present), Christopher is responsible for the strategic and operational leadership of the School, including its research, clinical and educational strategies and management of >500 staff working across a highly complex unit including veterinary hospitals and practices.

Research interests

Research Theme: Cardiac Diseases

 

 

 

 

 

Christopher Loughrey is Professor of Experimental Cardiology at the University of Glasgow (UK) and his research group use an integrative approach to study the pathophysiology of heart disease. His group has a particular focus on the mechanisms by which cardiac disease leads to changes in heart architecture and function and how this adverse cardiac remodelling leads to heart failure. His group have identified several new therapeutic targets with the translational potential to limit progression to heart failure in patients with myocardial infarction and in the context of Heart Failure with Preserved Ejection Fraction (HFpEF).

Key research areas include: Excitation-contraction coupling in cardiomyocytes, sarcoplasmic reticulum–mediated calcium handling, adverse cardiac remodelling, myocardial infarction, heart failure, heart failure with preserved ejection fraction, ischaemia-reperfusion injury, myocarditis, cathepsins and runt-related transcription factors (Runx1, Runx2 and Runx3).

Christopher Loughrey’s research group have expertise in a number of methodologies which span the level of the single cell, isolated organ, whole animal in vivo and patient including: confocal microscopy, single cell electrophysiology, fluorescence measurements/imaging, Western blotting, rtqPCR, isolated heart techniques (Langendorff perfusion and working heart preparations) and in vivo cardiac phenotyping/micro-surgery (e.g. intra-ventricular pressure-volume measurements, electrocardiography, echocardiography and mouse models of myocardial infarction, myocarditis, heart failure with preserved ejection fraction and ischaemia–reperfusion injury).

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2022 | 2020 | 2019 | 2018 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002
Number of items: 34.

2024

Loughrey, C. et al. (2024) A novel ryanodine receptor 2 inhibitor, M201-A, enhances natriuresis, renal function and lusi-inotropic action: Pre-clinical and phase I study. British Journal of Pharmacology, 181(18), pp. 3401-3419. (doi: 10.1111/bph.16379) (PMID:38773354)

2023

Martin, T. P. et al. (2023) Ribonucleicacid interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction. Cardiovascular Research, 119(16), 2663–2671-2663–2671. (doi: 10.1093/cvr/cvad107) (PMID:37433039) (PMCID:PMC10730241)

2022

He, W. et al. (2022) Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size. Cardiovascular Research, 118(6), pp. 1535-1547. (doi: 10.1093/cvr/cvab204) (PMID:34132807)

Martin, T. P. , MacDonald, E. A. , Elbassioni, A. A., Zaeri, A. A. I., O'Toole, D., Nicklin, S. A. , Gray, G. A. and Loughrey, C. M. (2022) Pre-clinical models of myocardial infarction: from mechanism to translation. British Journal of Pharmacology, 179(5), pp. 770-791. (doi: 10.1111/bph.15595) (PMID:34131903)

2020

Mangion, K. et al. (2020) Displacement encoding with stimulated echoes enables the identification of infarct transmurality early postmyocardial infarction. Journal of Magnetic Resonance Imaging, 52(6), pp. 1722-1731. (doi: 10.1002/jmri.27295) (PMID:32720405)

O'Toole, D., Zaeri, A. A. I., Nicklin, S. A. , French, A. T., Loughrey, C. M. and Martin, T. P. (2020) Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling. Cellular Signalling, 76, 109770. (doi: 10.1016/j.cellsig.2020.109770) (PMID:32891693)

Riddell, A. , McBride, M. , Braun, T., Nicklin, S. A. , Cameron, E. , Loughrey, C. M. and Martin, T. P. (2020) RUNX1: an emerging therapeutic target for cardiovascular disease. Cardiovascular Research, 116(8), pp. 1410-1423. (doi: 10.1093/cvr/cvaa034) (PMID:32154891) (PMCID:PMC7314639)

2019

Nather, K., Loughrey, C. M. and Nicklin, S. A. (2019) Vasoactive peptides: renin-angiotensin-aldosterone system. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 93-101. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_9)

2018

Guzik, T. J. et al. (2018) What matters in Cardiovascular Research? Scientific discovery driving clinical delivery. Cardiovascular Research, 114(12), pp. 1565-1568. (doi: 10.1093/cvr/cvy214)

McCarroll, C. S. et al. (2018) Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction. Circulation, 137(1), pp. 57-70. (doi: 10.1161/CIRCULATIONAHA.117.028911) (PMID:29030345) (PMCID:PMC5757664)

2016

Fattah, C. et al. (2016) Gene therapy with Angiotensin-(1-9) preserves left ventricular systolic function after myocardial infarction. Journal of the American College of Cardiology, 68(24), pp. 2652-2666. (doi: 10.1016/j.jacc.2016.09.946) (PMID:27978950) (PMCID:PMC5158000)

Ross, P. D. et al. (2016) Exclusive expression of MeCP2 in the nervous system distinguishes between brain and peripheral Rett syndrome-like phenotypes. Human Molecular Genetics, 25(20), pp. 4389-4404. (doi: 10.1093/hmg/ddw269) (PMID:28173151) (PMCID:PMC5886038)

2015

McCarroll, C. S., Rossor, C. L., Morrison, L. R., Morrison, L. J. and Loughrey, C. M. (2015) A pre-clinical animal model of Trypanosoma brucei infection demonstrating cardiac dysfunction. PLoS Neglected Tropical Diseases, 9(5), e0003811. (doi: 10.1371/journal.pntd.0003811) (PMID:26023927) (PMCID:PMC4449042)

2014

McKinney, C. A., Fattah, C., Loughrey, C. M. , Milligan, G. and Nicklin, S. A. (2014) Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodeling. Clinical Science, 126, pp. 815-827. (doi: 10.1042/CS20130436)

2013

Elliott, E.B. et al. (2013) T. brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes. Cardiovascular Research, 100(2), pp. 325-335. (doi: 10.1093/cvr/cvt187) (PMID:23892734) (PMCID:PMC3797627)

Loughrey, C.M. and Gray, G.A. (2013) Advancing our understanding of the pathophysiology of cardiac disease using in vivo assessment of heart structure and function in rodent models. Experimental Physiology, 98(3), pp. 599-600. (doi: 10.1113/expphysiol.2012.064550)

2012

Elliott, E.B., Kelly, A., Smith, G.L. and Loughrey, C.M. (2012) Isolated rabbit working heart function during progressive inhibition of myocardial SERCA activity. Circulation Research, 110(12), pp. 1618-1627. (doi: 10.1161/CIRCRESAHA.111.262337)

Kelly, A., Elliott, E.B., Matsuda, R., Kaneko, N., Smith, G.L. and Loughrey, C.M. (2012) The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically-induced Ca2+ overload. British Journal of Pharmacology, 165(4b), pp. 1068-1083. (doi: 10.1111/j.1476-5381.2011.01531.x)

2011

Currie, S., Elliott, E.B., Smith, G.L. and Loughrey, C.M. (2011) Two candidates at the heart of dysfunction: The ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention—An in vivo perspective. Pharmacology and Therapeutics, 131(2), pp. 204-220. (doi: 10.1016/j.pharmthera.2011.02.006)

Elliott, E.B., Hasumi, H., Otani, N., Matsuda, T., Matsuda, R., Kaneko, N., Smith, G.L. and Loughrey, C.M. (2011) K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca2+ release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes. Basic Research in Cardiology, 106(6), pp. 1009-1022. (doi: 10.1007/s00395-011-0218-4)

2010

Toischer, K. et al. (2010) K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Research in Cardiology, 105(2), pp. 279-287. (doi: 10.1007/s00395-009-0057-8)

2007

Volkers, M. et al. (2007) S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium, 41(2), pp. 135-143. (doi: 10.1016/j.ceca.2006.06.001) (PMID:16919727)

Loughrey, C., Otani, N., Seidler, T., Craig, M., Matsuda, R., Kaneko, N. and Smith, G. (2007) K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes. Cardiovascular Research, 76(2), pp. 236-246. (doi: 10.1016/j.cardiores.2007.06.014)

Seidler, T., Loughrey, C., Zibrova, D., Kettlewell, S., Teucher, N., Kogler, H., Hasenfuss, G. and Smith, G. (2007) Overexpression of FK-506-binding protein 12.0 modulates excitation-contraction coupling in adult rabbit ventricular cardiomyocytes. Circulation Research, 101(10), pp. 1020-1029. (doi: 10.1161/CIRCRESAHA.107.154609)

2006

Colotti, G., Zamparelli, C., Verzili, D., Mella, M., Loughrey, C., Smith, G. and Chiancone, E. (2006) The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca2+-dependent interaction with annexin VII and the cardiac ryanodine receptor. Biochemistry, 45(41), pp. 12519-12529. (doi: 10.1021/bi060416a)

2005

Miller, S., Currie, S., Loughrey, C., Kettlewell, S., Seidler, T., Reynolds, D., Hasenfuss, G. and Smith, G. (2005) Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Cardiovascular Research, 67(4), pp. 667-677. (doi: 10.1016/j.cardiores.2005.04.023)

2004

Loughrey, C.M. , Smith, G.L. and MacEachern, K.E. (2004) Comparison of Ca2+ release and uptake characteristics of the sarcoplasmic reticulum in isolated horse and rabbit cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 287(3), H1149-H1159. (doi: 10.1152/ajpheart.00060.2004) (PMID:15117716)

Loughrey, C.M. , Seidler, T., Miller, S.L.W., Prestle, J., MacEachern, K.E. , Reynolds, D.F., Hasenfuss, G. and Smith, G.L. (2004) Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes. Journal of Physiology, 556(3), pp. 919-934. (doi: 10.1113/jphysiol.2003.057166)

Currie, S., Loughrey, C., Craig, M. and Smith, G. (2004) Calcium/calmodulin-dependent protein kinase II delta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochemical Journal, 377(2), pp. 357-366. (doi: 10.1042/BJ200310431)

Wokosin, D., Loughrey, C. and Smith, G. (2004) Characterization of a range of fura dyes with two-photon excitation. Biophysical Journal, 86(3), pp. 1726-1738. (doi: 10.1016/S0006-3495(04)74241-1)

2003

Loughrey, C.M. , MacEachern, K.E. , Cooper, J. and Smith, G.L. (2003) Measurement of the dissociation constant of Fluo-3 for Ca2+ in isolated rabbit cardiomyocytes using Ca2+ wave characteristics. Cell Calcium, 34(1), pp. 1-9. (doi: 10.1016/S0143-4160(03)00012-5) (PMID:12767887)

Seidler, T. et al. (2003) Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Circulation Research, 93(2), pp. 132-139. (doi: 10.1161/01.RES.0000081596.90205.E2)

Zhang, H. et al. (2003) Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. International Journal of Bifurcation and Chaos, 13(12), pp. 3535-3560. (doi: 10.1142/S0218127403008843)

2002

Loughrey, C.M. , MacEachern, K.E. , Neary, P. and Smith, G.L. (2002) The relationship between intracellular [Ca2+] and Ca2+ wave characteristics in permeabilised cardiomyocytes from the rabbit. Journal of Physiology, 543(3), pp. 859-870. (doi: 10.1113/jphysiol.2002.021519) (PMID:12231644)

This list was generated on Sat Dec 21 11:02:24 2024 GMT.
Jump to: Articles | Book Sections
Number of items: 34.

Articles

Loughrey, C. et al. (2024) A novel ryanodine receptor 2 inhibitor, M201-A, enhances natriuresis, renal function and lusi-inotropic action: Pre-clinical and phase I study. British Journal of Pharmacology, 181(18), pp. 3401-3419. (doi: 10.1111/bph.16379) (PMID:38773354)

Martin, T. P. et al. (2023) Ribonucleicacid interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction. Cardiovascular Research, 119(16), 2663–2671-2663–2671. (doi: 10.1093/cvr/cvad107) (PMID:37433039) (PMCID:PMC10730241)

He, W. et al. (2022) Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size. Cardiovascular Research, 118(6), pp. 1535-1547. (doi: 10.1093/cvr/cvab204) (PMID:34132807)

Martin, T. P. , MacDonald, E. A. , Elbassioni, A. A., Zaeri, A. A. I., O'Toole, D., Nicklin, S. A. , Gray, G. A. and Loughrey, C. M. (2022) Pre-clinical models of myocardial infarction: from mechanism to translation. British Journal of Pharmacology, 179(5), pp. 770-791. (doi: 10.1111/bph.15595) (PMID:34131903)

Mangion, K. et al. (2020) Displacement encoding with stimulated echoes enables the identification of infarct transmurality early postmyocardial infarction. Journal of Magnetic Resonance Imaging, 52(6), pp. 1722-1731. (doi: 10.1002/jmri.27295) (PMID:32720405)

O'Toole, D., Zaeri, A. A. I., Nicklin, S. A. , French, A. T., Loughrey, C. M. and Martin, T. P. (2020) Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling. Cellular Signalling, 76, 109770. (doi: 10.1016/j.cellsig.2020.109770) (PMID:32891693)

Riddell, A. , McBride, M. , Braun, T., Nicklin, S. A. , Cameron, E. , Loughrey, C. M. and Martin, T. P. (2020) RUNX1: an emerging therapeutic target for cardiovascular disease. Cardiovascular Research, 116(8), pp. 1410-1423. (doi: 10.1093/cvr/cvaa034) (PMID:32154891) (PMCID:PMC7314639)

Guzik, T. J. et al. (2018) What matters in Cardiovascular Research? Scientific discovery driving clinical delivery. Cardiovascular Research, 114(12), pp. 1565-1568. (doi: 10.1093/cvr/cvy214)

McCarroll, C. S. et al. (2018) Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction. Circulation, 137(1), pp. 57-70. (doi: 10.1161/CIRCULATIONAHA.117.028911) (PMID:29030345) (PMCID:PMC5757664)

Fattah, C. et al. (2016) Gene therapy with Angiotensin-(1-9) preserves left ventricular systolic function after myocardial infarction. Journal of the American College of Cardiology, 68(24), pp. 2652-2666. (doi: 10.1016/j.jacc.2016.09.946) (PMID:27978950) (PMCID:PMC5158000)

Ross, P. D. et al. (2016) Exclusive expression of MeCP2 in the nervous system distinguishes between brain and peripheral Rett syndrome-like phenotypes. Human Molecular Genetics, 25(20), pp. 4389-4404. (doi: 10.1093/hmg/ddw269) (PMID:28173151) (PMCID:PMC5886038)

McCarroll, C. S., Rossor, C. L., Morrison, L. R., Morrison, L. J. and Loughrey, C. M. (2015) A pre-clinical animal model of Trypanosoma brucei infection demonstrating cardiac dysfunction. PLoS Neglected Tropical Diseases, 9(5), e0003811. (doi: 10.1371/journal.pntd.0003811) (PMID:26023927) (PMCID:PMC4449042)

McKinney, C. A., Fattah, C., Loughrey, C. M. , Milligan, G. and Nicklin, S. A. (2014) Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodeling. Clinical Science, 126, pp. 815-827. (doi: 10.1042/CS20130436)

Elliott, E.B. et al. (2013) T. brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes. Cardiovascular Research, 100(2), pp. 325-335. (doi: 10.1093/cvr/cvt187) (PMID:23892734) (PMCID:PMC3797627)

Loughrey, C.M. and Gray, G.A. (2013) Advancing our understanding of the pathophysiology of cardiac disease using in vivo assessment of heart structure and function in rodent models. Experimental Physiology, 98(3), pp. 599-600. (doi: 10.1113/expphysiol.2012.064550)

Elliott, E.B., Kelly, A., Smith, G.L. and Loughrey, C.M. (2012) Isolated rabbit working heart function during progressive inhibition of myocardial SERCA activity. Circulation Research, 110(12), pp. 1618-1627. (doi: 10.1161/CIRCRESAHA.111.262337)

Kelly, A., Elliott, E.B., Matsuda, R., Kaneko, N., Smith, G.L. and Loughrey, C.M. (2012) The effect of K201 on isolated working rabbit heart mechanical function during pharmacologically-induced Ca2+ overload. British Journal of Pharmacology, 165(4b), pp. 1068-1083. (doi: 10.1111/j.1476-5381.2011.01531.x)

Currie, S., Elliott, E.B., Smith, G.L. and Loughrey, C.M. (2011) Two candidates at the heart of dysfunction: The ryanodine receptor and calcium/calmodulin protein kinase II as potential targets for therapeutic intervention—An in vivo perspective. Pharmacology and Therapeutics, 131(2), pp. 204-220. (doi: 10.1016/j.pharmthera.2011.02.006)

Elliott, E.B., Hasumi, H., Otani, N., Matsuda, T., Matsuda, R., Kaneko, N., Smith, G.L. and Loughrey, C.M. (2011) K201 (JTV-519) alters the spatiotemporal properties of diastolic Ca2+ release and the associated diastolic contraction during β-adrenergic stimulation in rat ventricular cardiomyocytes. Basic Research in Cardiology, 106(6), pp. 1009-1022. (doi: 10.1007/s00395-011-0218-4)

Toischer, K. et al. (2010) K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca2+ leak from the sarcoplasmic reticulum. Basic Research in Cardiology, 105(2), pp. 279-287. (doi: 10.1007/s00395-009-0057-8)

Volkers, M. et al. (2007) S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes. Cell Calcium, 41(2), pp. 135-143. (doi: 10.1016/j.ceca.2006.06.001) (PMID:16919727)

Loughrey, C., Otani, N., Seidler, T., Craig, M., Matsuda, R., Kaneko, N. and Smith, G. (2007) K201 modulates excitation-contraction coupling and spontaneous Ca2+ release in normal adult rabbit ventricular cardiomyocytes. Cardiovascular Research, 76(2), pp. 236-246. (doi: 10.1016/j.cardiores.2007.06.014)

Seidler, T., Loughrey, C., Zibrova, D., Kettlewell, S., Teucher, N., Kogler, H., Hasenfuss, G. and Smith, G. (2007) Overexpression of FK-506-binding protein 12.0 modulates excitation-contraction coupling in adult rabbit ventricular cardiomyocytes. Circulation Research, 101(10), pp. 1020-1029. (doi: 10.1161/CIRCRESAHA.107.154609)

Colotti, G., Zamparelli, C., Verzili, D., Mella, M., Loughrey, C., Smith, G. and Chiancone, E. (2006) The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca2+-dependent interaction with annexin VII and the cardiac ryanodine receptor. Biochemistry, 45(41), pp. 12519-12529. (doi: 10.1021/bi060416a)

Miller, S., Currie, S., Loughrey, C., Kettlewell, S., Seidler, T., Reynolds, D., Hasenfuss, G. and Smith, G. (2005) Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Cardiovascular Research, 67(4), pp. 667-677. (doi: 10.1016/j.cardiores.2005.04.023)

Loughrey, C.M. , Smith, G.L. and MacEachern, K.E. (2004) Comparison of Ca2+ release and uptake characteristics of the sarcoplasmic reticulum in isolated horse and rabbit cardiomyocytes. American Journal of Physiology: Heart and Circulatory Physiology, 287(3), H1149-H1159. (doi: 10.1152/ajpheart.00060.2004) (PMID:15117716)

Loughrey, C.M. , Seidler, T., Miller, S.L.W., Prestle, J., MacEachern, K.E. , Reynolds, D.F., Hasenfuss, G. and Smith, G.L. (2004) Over-expression of FK506-binding protein FKBP12.6 alters excitation-contraction coupling in adult rabbit cardiomyocytes. Journal of Physiology, 556(3), pp. 919-934. (doi: 10.1113/jphysiol.2003.057166)

Currie, S., Loughrey, C., Craig, M. and Smith, G. (2004) Calcium/calmodulin-dependent protein kinase II delta associates with the ryanodine receptor complex and regulates channel function in rabbit heart. Biochemical Journal, 377(2), pp. 357-366. (doi: 10.1042/BJ200310431)

Wokosin, D., Loughrey, C. and Smith, G. (2004) Characterization of a range of fura dyes with two-photon excitation. Biophysical Journal, 86(3), pp. 1726-1738. (doi: 10.1016/S0006-3495(04)74241-1)

Loughrey, C.M. , MacEachern, K.E. , Cooper, J. and Smith, G.L. (2003) Measurement of the dissociation constant of Fluo-3 for Ca2+ in isolated rabbit cardiomyocytes using Ca2+ wave characteristics. Cell Calcium, 34(1), pp. 1-9. (doi: 10.1016/S0143-4160(03)00012-5) (PMID:12767887)

Seidler, T. et al. (2003) Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Circulation Research, 93(2), pp. 132-139. (doi: 10.1161/01.RES.0000081596.90205.E2)

Zhang, H. et al. (2003) Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. International Journal of Bifurcation and Chaos, 13(12), pp. 3535-3560. (doi: 10.1142/S0218127403008843)

Loughrey, C.M. , MacEachern, K.E. , Neary, P. and Smith, G.L. (2002) The relationship between intracellular [Ca2+] and Ca2+ wave characteristics in permeabilised cardiomyocytes from the rabbit. Journal of Physiology, 543(3), pp. 859-870. (doi: 10.1113/jphysiol.2002.021519) (PMID:12231644)

Book Sections

Nather, K., Loughrey, C. M. and Nicklin, S. A. (2019) Vasoactive peptides: renin-angiotensin-aldosterone system. In: Touyz, R. M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer: Cham, pp. 93-101. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_9)

This list was generated on Sat Dec 21 11:02:24 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Cross disciplinary capacity building in ultra-high frequency preclinical cardiovascular ultrasound
    British Heart Foundation
    2022 - 2025
     
  • Correlative Optical investiagtion of cardiac Eletrophysiology Under Remodelling
    British Heart Foundation
    2022 - 2025
     
  • Mitochondrial function in Heart Failure with Preserved Ejection Fraction and Myocardial infarction
    Heart Research Institute
    2022 - 2023
     
  • Cardiac-targeted exosome-mediated delivery of angiotensin-(1-7) to treat cardiac disease
    British Heart Foundation
    2021 - 2024
     
  • Targeting RUNX to Attenuate Adverse Cardiac Remodelling
    British Heart Foundation
    2021 - 2026
     
  • Elucidation of molecular pathways underlying cardiac disease caused by Col4a1 mutations
    Heart Research UK
    2018 - 2021
     
  • Investigating the Therapeutic Potential of Runx1 for Myocardial Infarction
    British Heart Foundation
    2018 - 2022
     
  • Elucidation of molecular pathways underlying cardiac disease caused by Col4a1 mutations
    Heart Research UK
    2018 - 2022
     
  • Small molecules activating Nrf2 as a therapeutic approach to prevent cardiac ischemiareperfusion
    British Heart Foundation
    2018 - 2019
     
  • Cardiac gene therapy with angiotensin-(1-9): dissecting the underlying mechanism for preservation of cardiac function post-myocardial infarction
    British Heart Foundation
    2017 - 2020
     
  • Small molecules activating Nrf2 as a therapeutic approach to prevent cardiac ischemia-reperfusion injury
    British Heart Foundation
    2017 - 2019
     
  • INSPIRE Award
    Academy of Medical Sciences
    2016 - 2017
     
  • INVESTIGATING THE ROLE OF RUNX1 IN THE HEART POST-MYOCARDIAL INFARCTION
    Medical Research Council
    2015 - 2018
     
  • Investigation of Osteopontin as a candidate gene for left ventricular hypertrophy
    British Heart Foundation
    2014 - 2018
     
  • Angiotensin-(1-9) a novel peptide therapeutic for improving cardiac function.
    Medical Research Council
    2014 - 2015
     
  • Investigating the therapeutic potential of cathepsin-L inhibition to limit ischaemia-reperfusion injury in the heart
    Chief Scientist Office
    2013 - 2016
     
  • Investigating the potential of cathepsin-L as a common therapeutic target and biomarker for coronary heart disease and African trypanosomiasis (ISSF Catalyst Fund)
    Wellcome Trust
    2011 - 2014
     
  • Angiotensin 1-9 and angiotensin 1-7: assessment of their mechanisms of action as counter-regulatory renin angiotensin system peptides in cardiovascular disease
    British Heart Foundation
    2011 - 2015
     
  • Investigating the expression and function of RUNX1 in cardiac tissue during myocardial infarction
    British Heart Foundation
    2009 - 2011
     
  • The role of direct parasite-cardiomyocyte interaction in the pathogenesis of the cardiac dysfunction observed in mammals with African trypanosomiasis
    Royal College of Veterinary Surgeons
    2008 - 2009
     
  • Targeted disruption of sarcoplasmic reticulum mediated Ca2+ handling and diastolic dysfunction: A comaprison between isolated cardiomyocytes and the whole heart.
    Heart Research UK
    2007 - 2009
     
  • Investigating the role of intracellular calcium in the left ventricular diastolic dysfunction
    Medical Research Scotland
    2006 - 2008
     
  • Cellular Basis of Arrhythmias:The Inter-Relationship between Ca2+ Transients and Ca2+ Waves in Cardiac Muscle
    British Heart Foundation
    2006 - 2009
     
  • Use of Micro-Conductance Technology to investigate the link between altered sarcoplasmic reticulum calcium dynamics & diastolic dysfunction.
    Tenovus Scotland
    2005 - 2006
     
  • Use of micro-conductance technology to study cardiac pressure-volume (PV) relations in ex vivo whole rabbit hearts during acute application.
    The Royal Society
    2005 - 2006
     

Supervision

  • Black, Iain
    Investigating the mechanisms of acute preservation of cardiac function post-MI following angiotensin-(1-9) gene therapy
  • Booth, Emma
    The role of IL15 in angiotensin II-mediated cardiac remodelling
  • Crichton, Conor
    One Health Approach to Cardio-Oncology Research in Veterinary Medicine
  • Raheem, Anmar
    Developing Therapeutic Approaches for Hemorrhagic Stroke
  • Song, Jian
    Runx1 and Heart Disease Post-Myocardial Infarction
  • Zhang, Haobo
    Runx1 and Heart Failure

Teaching

Professor Loughrey has supervised a substantial number of PhD and Masters students (>40) all to completion since 2005. He also teaches, assesses and mentors both undergraduates and postgraduate Masters students on the following degree programmes:

School of Veterinary Medicine: (BVMS and BSc Veterinary Biosciences)

School of Cardiovascular & Metabolic Health (British Heart Foundation MRes programme)

Professional activities & recognition

Prizes, awards & distinctions

  • 2023: (Fellowship of the Royal Society of Biology)
  • 2023: University of Sydney (Honorary Professor)
  • 2008: FHEA (Fellow of the Higher Education Academy)
  • 2005: Annual Presentations by Britain's Top Young Scientists (House of Commons)
  • 2003: Judge's Prize (British Cardiac Society)
  • 2001: President's Prize (Association of Veterinary Teachers and Research Workers (AVTRW))
  • 2000: Commendation (BVMS MRCVS)
  • 1997: (Royal Agricultural Society Medal)
  • 1997: (Eukanuba Prize)

Grant committees & research advisory boards

  • 2013 - 2013: Wellcome Trust, Clinical Veterinary Research Training Wellcome Trust grant panel, UK
  • 2010 - 2010: Wellcome Trust, Advisor on the International Mouse Phenotyping Project
  • 2023: Imperial College London, Advisory Appointments Committee National Heart and Lung Institute.
  • 2021 - 2024: British Heart Foundation, Project Grants Committee

Editorial boards

  • 2018: Deputy Executive Editor for Cardiovascular Research
  • 2017 - 2021: Editorial Board for the British Journal of Pharmacology
  • 2017 - 2021: Editorial Board for Frontiers in Physiology (Cardiac Electrophysiology)

Professional & learned societies

  • Professional Member, American Heart Association
  • Member, European Society of Cardiology (Working groups; Cardiac Cellular Electrophysiology, Cell Biology and Myocardial Function)
  • Member, International Society for Heart Research
  • Member, Physiological Society
  • Member, British Veterinary Association
  • Member, Royal College of Veterinary Surgeons
  • Member, Biophysical Society (USA)
  • Fellow, Royal Society of Biology
  • Member, British Society of Cardiovascular Research (UK)

Selected international presentations

  • 2003: British Cardiac Society Annual Conference (UK)
  • 2003: Association of Veterinary Teachers and Research Workers (UK)
  • 2008: Norwegian University of Science and Technology (Norway)
  • 2008: Medical Research Scotland (UK)
  • 2007/9: Aetas Pharma Ltd (Japan)
  • 2012: John Hopkins (USA)
  • 2013: Comparative Clinical Science Foundation; Wellcome Trust (UK)
  • 2015: Dundee University (UK)
  • 2015/16: European Society of Cardiology (UK)
  • 2015: British Society of Cardiovascular Research Meeting (UK)
  • 2016: Imperial College London (UK)
  • 2016: University of Manchester (UK)
  • 2017: Oxford University (UK)
  • 2019: PSG College of Arts and Science (India)
  • 2020: Mahidol University (Thailand)
  • 2019: Wuhan University (China)
  • 2020: International Society for Heart Research (UK)
  • 2021: Edinburgh University (UK)
  • 2022: China Academy of Chines Medical Sciences, Institute of Chinese Materia Medica (China)
  • 2022: University of Birmingham (UK)
  • 2022: Chulalongkorn University Cardiac Conference (Thailand)
  • 2023: International Society for Heart Research (Portugal)

Profile