Professor Dame Anna Dominiczak
- Regius Professor of Medicine (Cardiovascular & Metabolic Health)
telephone:
01413308564
email:
Anna.Dominiczak@glasgow.ac.uk
Institute of Cardiovascular & Medical Sciences, Room C235, Level 2, BHF GCRC, 126 University Place, Glasgow, G12 8TA
https://orcid.org/0000-0003-4913-3608Biography
Professor Dame Anna Dominiczak DBE, OBE, MD, FRCP, FAHA, FRSE, FMedSci
Regius Professor of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow
Professor Dame Anna Dominiczak is Regius Professor of Medicine at the University of Glasgow; Honorary Consultant Physician and Endocrinologist at NHS Greater Glasgow and Clyde; and Chief Scientist (Health) for the Scottish Government.
Recognised as a world-leading cardiovascular scientist and clinical academic, she held a British Heart Foundation Chair of Cardiovascular Medicine at University of Glasgow between 1997 and 2010, and directorship of the BHF Cardiovascular Research Centre between 2000 and 2010. Her major research interests are in hypertension, cardiovascular genomics and precision medicine, where she not only publishes extensively in top peer-reviewed journals (over 500 publications), but also excels in large scale research funding for programmes and infrastructure (with a total value more than £100M over the last ten years). This included a leadership of a major fundraising initiative with the British Heart Foundation.
From 2010 – 2020, Professor Dominiczak was Vice-Principal and Head of the College of Medical, Veterinary and Life Sciences at the University of Glasgow. She was the driving force behind the fundraising, development and delivery of the University’s clinical academic campus at Queen Elizabeth University Hospital in Glasgow, comprising Clinical Research Facilities; a Teaching and Learning Centre; a state-of-the-art Imaging Centre of Excellence (including the UK’s first 7Tesla MRI scanner in a clinical setting); and a Clinical Innovation Zone. She led a triple helix partnership between academia, the NHS and industry to accelerate innovation, maximise patient benefit and stimulate business growth, including a collaboration of four Scottish universities, four NHS Health Boards across Scotland and two major industry partners in a public/private partnership focused on precision medicine.
She is a Fellow of the Royal College of Physicians, the American Heart Association, the Academy of Medical Sciences, the Royal Society of Edinburgh, the European Society of Cardiology and the Royal Society of Biology. She is a member of the British Medical Association, the British and Irish Hypertension Society, the European Society of Hypertension, the International Society of Hypertension, the British Endocrine Society, the American Physiological Society, the British Atherosclerosis Society, the British Cardiovascular Society and the European Atherosclerosis Society. From 2013 to 2015, she was President of the European Society of Hypertension. She is a past President of the Association of Physicians of Great Britain and Ireland, past Vice President for Life Sciences of the Royal Society of Edinburgh, and Health Innovation Champion for the Medical Research Council.
Professor Dominiczak had served as a trustee of the Academy of Medical Sciences, British Heart Foundation, UK Medical Schools Council, Royal Society of Edinburgh, Greater Glasgow and Clyde Health Board and the Beatson Cancer Research Centre. She currently serves on two major international scientific advisory boards, the Inserm Cardiovascular Unit in Paris and the International Cardiovascular Research Centre in Madrid
She has been invited to give over 100 international plenary lectures, including the Presidential Award and Lecture of the Canadian Hypertension Society, the Arthur Corcoran Award and Lecture of the American Heart Association, the R.D. Wright Award and Lecture of the High Blood Pressure Research Council of Australia, the Bjorn Folkow Award and Lecture of the European Society of Hypertension, the William Harvey Outstanding Contribution to Science Award and Lecture, Queen Mary University of London, the Robert Tigerstedt Award and Lecture of the Finnish Hypertension Society, and Pickering Lecture of British & Irish Hypertension Society as well as many plenary lectures on health innovation and precision medicine.
Professor Dominiczak has invested time and excellence in scientific publishing, with three major roles as Editor in Chief undertaken in succession: for Clinical Science, Hypertension, journal of the American Heart Association and the world’s top journal in her area of research and her current role as Editor in Chief for Precision Medicine, Prism Journal of Cambridge Press.
Professor Dominiczak was seconded to the Department of Health and Social Care in the UK Government between August 2020 and June 2022 as Director of Laboratories. In March 2020, she successfully led the establishment of the Lighthouse Laboratory in Glasgow, followed by an invitation to lead the UK - wide Lighthouse laboratory network, including a role of SRO for planning and building the biggest ever laboratory in the UK, the Rosalind Franklin laboratory.
In July 2022 Professor Dominiczak was appointed as Chief Scientist (Health) for the Scottish Government, where she leads and coordinates health research and innovation, working in partnership with the NHS, academia and industry to develop rapid translation and adoption of transformative innovations for the Scottish NHS.
Publications
2024
McCallum, L. et al. (2024) UMOD genotype-dependent effects of Torasemide on ambulatory blood pressure: a multicentre genotype-blinded trial. Hypertension, 81(10), pp. 2049-2059. (doi: 10.1161/HYPERTENSIONAHA.124.23122) (PMID:39077768) (PMCID:PMC11460757)
Zhou, M., Mary, S. , Delles, C. , Padmanabhan, S. , Graham, D. , McBride, M. W. and Dominiczak, A. (2024) Insights into uromodulin and blood pressure. Current Hypertension Reports, (doi: 10.1007/s11906-024-01317-0) (PMID:39259220) (Early Online Publication)
Padmanabhan, S. , Delles, C. and Dominiczak, A. F. (2024) Beyond genome-wide scans: advancing hypertension genomics into the future. Hypertension, 81(6), pp. 1186-1189. (doi: 10.1161/HYPERTENSIONAHA.124.21371) (PMID:38748763)
Tran, T. Q. B. et al. (2024) Assessing machine learning for diagnostic classification of hypertension types identified by ambulatory blood pressure monitoring. CJC Open, 6(6), pp. 798-804. (doi: 10.1016/j.cjco.2024.03.005) (PMID:39022171) (PMCID:PMC11250845)
Keaton, J. M. et al. (2024) Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. Nature Genetics, 56(5), pp. 778-791. (doi: 10.1038/s41588-024-01714-w) (PMID:38689001) (PMCID:PMC11096100)
2023
Cui, L. et al. (2023) Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing. Genome Biology, 24(1), 215. (doi: 10.1186/s13059-023-03060-2) (PMID:37773188) (PMCID:PMC10540365)
Brown, C. E., Casey, H., Dominiczak, A. F. , Kerr, S., Campbell, A. and Delles, C. (2023) Impact of preeclampsia on cardiovascular events: an analysis of the Generation Scotland: Scottish family health study. Journal of Human Hypertension, 37(8), pp. 735-741. (doi: 10.1038/s41371-023-00812-2) (PMID:36973315)
Arisido, M. W. et al. (2023) Cluster analysis of angiotensin biomarkers to identify antihypertensive drug treatment in population studies. BMC Medical Research Methodology, 23, 131. (doi: 10.1186/s12874-023-01930-8) (PMID:37245005) (PMCID:PMC10224304)
Tran, T. Q. B. et al. (2023) Predictive accuracy and clinical utility of machine learning prediction for classifying blood pressure status. SSRN, (doi: 10.2139/ssrn.4307704)
Padmanabhan, S. , Du Toit, C. and Dominiczak, A. F. (2023) Cardiovascular precision medicine – a pharmacogenomic perspective. Cambridge Prisms: Precision Medicine, 1, pp. 1-54. e28. (doi: 10.1017/pcm.2023.17)
2022
Mary, S. , Boder, P., Padmanabhan, S. , McBride, M. W. , Graham, D. , Delles, C. and Dominiczak, A. F. (2022) The role of uromodulin in salt-sensitive hypertension. Hypertension, 79, pp. 2419-2429. (doi: 10.1161/HYPERTENSIONAHA.122.19888) (PMID:36378920) (PMCID:PMC9553220)
Le, N. N., Tran, T. Q. B., Lip, S. , McCallum, L., McClure, J. , Dominiczak, A. F. , Gill, D. and Padmanabhan, S. (2022) Unravelling the distinct effects of systolic and diastolic blood pressure using Mendelian randomisation. Genes, 13(7), 1226. (doi: 10.3390/genes13071226) (PMID:35886009) (PMCID:PMC9323763)
Chen, J., Chen, X., Dominiczak, A. F. , Carey, R. M., Laffer, C. L., Elijovich, F., Taler, S. J., Dudenbostel, T., Touyz, R. M. and Wang, J.-G. (2022) A rare disease leading to hypertension. Hypertension, 79(6), pp. 1147-1152. (doi: 10.1161/HYPERTENSIONAHA.122.18678) (PMID:35300529)
Lopez, A.-G., Dominiczak, A. F. , Touyz, R. , Schlaich, M., de Freminville, J.-B. and Amar, L. (2022) Hypertension with negative metaiodobenzylguanidine scintigraphy. Hypertension, 79(2), pp. 474-478. (doi: 10.1161/HYPERTENSIONAHA.121.18012) (PMID:34879700)
2021
Dominiczak, A. F. and Meyer, T. J. (2021) Hypertension update: a reflection of the past decade. Hypertension, 78(6), pp. 1670-1673. (doi: 10.1161/HYPERTENSIONAHA.121.18596) (PMID:34757771) (PMCID:PMC8577297)
Boder, P., Mary, S. , Mark, P. B. , Leiper, J. , Dominiczak, A. F. , Padmanabhan, S. , Rampold, L. and Delles, C. (2021) Mechanistic interactions of uromodulin with the thick ascending limb: perspectives in physiology and hypertension. Journal of Hypertension, 39(8), pp. 1490-1504. (doi: 10.1097/HJH.0000000000002861) (PMID:34187999) (PMCID:PMC7611110)
Padmanabhan, S. and Dominiczak, A. F. (2021) Genomics of hypertension: the road to precision medicine. Nature Reviews Cardiology, 18(4), pp. 235-250. (doi: 10.1038/s41569-020-00466-4) (PMID:33219353)
2020
Surendran, P. et al. (2020) Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics, 52(12), pp. 1314-1332. (doi: 10.1038/s41588-020-00713-x) (PMID:33230300) (PMCID:PMC7610439)
Steinthorsdottir, V. et al. (2020) Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women. Nature Communications, 11, 5976. (doi: 10.1038/s41467-020-19733-6) (PMID:33239696) (PMCID:PMC7688949)
Erzurumluoglu, A. M. et al. (2020) Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. Molecular Psychiatry, 25(10), pp. 2392-2409. (doi: 10.1038/s41380-018-0313-0) (PMID:30617275) (PMCID:PMC7515840)
Dominiczak, A. and Mancia, G. (2020) Joint editorial for the International Society of Hypertension guidelines. Hypertension, 75(6), p. 1419. (doi: 10.1161/HYPERTENSIONAHA.120.15224) (PMID:32370573)
Ntalla, I. et al. (2020) Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nature Communications, 11, 2542. (doi: 10.1038/s41467-020-15706-x) (PMID:32439900) (PMCID:PMC7242331)
2019
Teumer, A. et al. (2019) KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern. JCI Insight, 4(23), e131156. (doi: 10.1172/jci.insight.131156) (PMID:31600170) (PMCID:PMC6962032)
Cameron, A. C. et al. (2019) Progressive hypertension and severe left ventricular outflow tract obstruction. Hypertension, 74(6), pp. 1216-1225. (doi: 10.1161/hypertensionaha.119.13343) (PMID:31587571)
Aitken, S. et al. (2019) Finding diagnostically useful patterns in quantitative phenotypic data. American Journal of Human Genetics, 105(5), pp. 933-946. (doi: 10.1016/j.ajhg.2019.09.015) (PMID:31607427)
Dominiczak, A. F. , de Champvallins, M., Brzozowska-Villatte, R. and Asmar, R. (2019) Efficacy of a new single-pill combination of a thiazide-like diuretic and a calcium channel blocker (indapamide sustained release/amlodipine) in essential hypertension. Journal of Hypertension, 37(11), pp. 2280-2289. (doi: 10.1097/HJH.0000000000002177) (PMID:31246894)
Lip, S. , Tan, L. E., Jeemon, P., McCallum, L., Dominiczak, A. F. and Padmanabhan, S. (2019) Diastolic blood pressure J-curve phenomenon in a tertiary-care hypertension clinic. Hypertension, 74(4), pp. 767-775. (doi: 10.1161/HYPERTENSIONAHA.119.12787) (PMID:31422693) (PMCID:PMC6756261)
Luther, J. M., Dominiczak, A. F. , Jennings, G. L.R., VanDevender, F. K., Carey, R. M., Peixoto, A. J., Chung, C. P. and Oates, J. A. (2019) Paroxysmal hypertension associated with presyncope. Hypertension, 74(4), pp. 718-725. (doi: 10.1161/hypertensionaha.119.13341) (PMID:31476903)
Romagnoni, A. et al. (2019) Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data. Scientific Reports, 9, 10351. (doi: 10.1038/s41598-019-46649-z) (PMID:31316157) (PMCID:PMC6637191)
de Vries, P. S. et al. (2019) Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions. American Journal of Epidemiology, 188(6), pp. 1033-1054. (doi: 10.1093/aje/kwz005) (PMID:30698716)
Noordam, R. et al. (2019) Effects of calcium, magnesium, and potassium concentrations on ventricular repolarization in unselected individuals. Journal of the American College of Cardiology, 73(24), pp. 3118-3131. (doi: 10.1016/j.jacc.2019.03.519) (PMID:31221261)
Olson, E., Pravenec, M., Landa, V., Koh-Tan, H. H. C., Dominiczak, A. F. , McBride, M. W. and Graham, D. (2019) Transgenic overexpression of glutathione S-transferase μ-type 1 reduces hypertension and oxidative stress in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 37(5), pp. 985-996. (doi: 10.1097/HJH.0000000000001960) (PMID:30308595)
Haworth, S. et al. (2019) Low-frequency variation in TP53 has large effects on head circumference and intracranial volume. Nature Communications, 10, 357. (doi: 10.1038/s41467-018-07863-x) (PMID:30664637) (PMCID:PMC6341110)
van Twist, D. J.L., de Leeuw, P. W., Spiering, W., Rossi, G. P., Dominiczak, A. F. , Jennings, G. L.R., Barigou, M., Persu, A. and Kroon, A. A. (2019) Unifocal and multifocal fibromuscular dysplasia: two different disease entities in a single patient? Hypertension, 73(1), pp. 7-12. (doi: 10.1161/HYPERTENSIONAHA.118.12004) (PMID:30571541)
Cameron, A.C., Dominiczak, A.F. and Touyz, R.M. (2019) Hypertension. In: Touyz, R.M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer Nature Switzerland: Cham, Switzerland, pp. 331-341. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_31)
Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2019) Genetics of hypertension and heart failure. In: Dorobantu, M., Mancia, G., Grassi, G. and Voicu, V. (eds.) Hypertension and Heart Failure. Series: Updates in hypertension and cardiovascular protection. Springer International Publishing, pp. 15-29. ISBN 9783319933191
Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2019) Genomics of hypertension. In: Touyz, R.M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer, pp. 171-181. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_16)
2018
Graham, L. A. , Aman, A. , Campbell, D. D. , Augley, J., Graham, D. , McBride, M. W. , Fraser, N. J., Ferreri, N. R., Dominiczak, A. F. and Padmanabhan, S. (2018) Salt stress in the renal tubules is linked to TAL specific expression of uromodulin and an upregulation of heat shock genes. Physiological Genomics, 50(11), pp. 964-972. (doi: 10.1152/physiolgenomics.00057.2018) (PMID:30216136) (PMCID:PMC6293113)
Williams, B. et al. (2018) 2018 ESC/ESH Guidelines for the management of arterial hypertension. European Heart Journal, 39(33), pp. 3021-3104. (doi: 10.1093/eurheartj/ehy339) (PMID:30165516)
Ravassa, S. et al. (2018) Biomarker-based phenotyping of myocardial fibrosis identifies patients with heart failure with preserved ejection fraction resistant to the beneficial effects of spironolactone: results from the Aldo-DHF trial. European Journal of Heart Failure, 20(9), pp. 1290-1299. (doi: 10.1002/ejhf.1194) (PMID:29709099)
Van Setten, J. et al. (2018) PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. Nature Communications, 9, 2904. (doi: 10.1038/s41467-018-04766-9) (PMID:30046033) (PMCID:PMC6060178)
Prins, B. P. et al. (2018) Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Genome Biology, 19, 87. (doi: 10.1186/s13059-018-1457-6) (PMID:30012220) (PMCID:PMC6048820)
Rajani, R. M. et al. (2018) Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Science Translational Medicine, 10(448), eaam9507. (doi: 10.1126/scitranslmed.aam9507) (PMID:29973407)
Bailey, E. , McBride, M. W. , McClure, J. D. , Beattie, W., Graham, D. , Dominiczak, A. , Smith, C. and Wardlaw, J. (2018) Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease. Clinical Science, 132(12), pp. 1315-1328. (doi: 10.1042/CS20171572) (PMID:29632138) (PMCID:PMC6365623)
Bursztyn, M., Touyz, R. M. , Laffer, C. L., Carey, R. M. and Dominiczak, A. F. (2018) Case of severe hypertension and nephrotic range proteinuria. Hypertension, 71(6), pp. 956-961. (doi: 10.1161/HYPERTENSIONAHA.118.11045) (PMID:29610267)
Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2018) Recent findings in the genetics of blood pressure: how to apply in practice or is a moonshot required? Current Hypertension Reports, 20, 54. (doi: 10.1007/s11906-018-0863-1) (PMID:29881931) (PMCID:PMC5992231)
Berra, E. et al. (2018) Management of a pregnant woman with fibromuscular dysplasia. Hypertension, 71(4), pp. 540-547. (doi: 10.1161/HYPERTENSIONAHA.118.10819) (PMID:29483231)
Oparil, S. et al. (2018) Hypertension. Nature Reviews Disease Primers, 4, 18014. (doi: 10.1038/nrdp.2018.14)
Feng, Y.-M. et al. (2018) Glomerular function in relation to circulating adhesion molecules and inflammation markers in a general population. Nephrology Dialysis Transplantation, 33(3), pp. 426-435. (doi: 10.1093/ndt/gfx256) (PMID:28992257)
Bihlmeyer, N. A. et al. (2018) ExomeChip-wide analysis of 95 626 individuals identifies 10 novel loci associated with QT and JT intervals. Circulation: Genomic and Precision Medicine, 11(1), e001758. (doi: 10.1161/CIRCGEN.117.001758) (PMID:29874175) (PMCID:PMC5992491)
Padmanabhan, S. , Tan, L.-E. and Dominiczak, A. F. (2018) Genetics of blood pressure and hypertension. In: Berbari, A.E. and Mancia, G. (eds.) Disorders of Blood Pressure Regulation. Series: Updates in hypertension and cardiovascular protection. Springer, pp. 135-154. ISBN 9783319599175 (doi: 10.1007/978-3-319-59918-2_10)
Williams, B. et al. (2018) 2018 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC). Blood Pressure, 27(6), pp. 314-340. (doi: 10.1080/08037051.2018.1527177) (PMID:30380928)
2017
Kraja, A. T. et al. (2017) New blood pressure–associated loci identified in meta-analyses of 475 000 individuals. Circulation: Cardiovascular Genetics, 10(5), e001778. (doi: 10.1161/CIRCGENETICS.117.001778) (PMID:29030403)
McGinnis, R. et al. (2017) Variants in the fetal genome near FLT1 are associated with risk of preeclampsia. Nature Genetics, 49(8), pp. 1255-1260. (doi: 10.1038/ng.3895) (PMID:28628106)
Zhang, Z.‐Y. et al. (2017) Novel urinary peptidomic classifier predicts incident heart failure. Journal of the American Heart Association, 6(8), e005432. (doi: 10.1161/JAHA.116.005432) (PMID:28784649) (PMCID:PMC5586413)
Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2017) Genomics of hypertension. Pharmacological Research, 121, pp. 219-229. (doi: 10.1016/j.phrs.2017.04.031) (PMID:28495658)
van den Berg, M. E. et al. (2017) Discovery of novel heart rate-associated loci using the Exome Chip. Human Molecular Genetics, 26(12), pp. 2346-2363. (doi: 10.1093/hmg/ddx113) (PMID:28379579) (PMCID:PMC5458336)
Calvet, D., Amar, L., Rossi, G. P., Laurent, S., Dominiczak, A. F. , Turc, G., Jennings, G., Guzik, T. and Touyz, R. M. (2017) Case of asymptomatic carotid artery stenosis in a hypertensive patient. Hypertension, 69(6), pp. 985-991. (doi: 10.1161/HYPERTENSIONAHA.117.09330) (PMID:28461597)
Lee, C. J., Kim, B.-K., Yoon, K. B., Lee, H.-Y., Dominiczak, A. F. , Touyz, R. M. , Jennings, G. L.R., Cho, E. J., Hering, D. and Park, S. (2017) Case of refractory hypertension controlled by repeated renal denervation and celiac plexus block: a case of refractory sympathetic overload. Hypertension, 69(6), pp. 978-984. (doi: 10.1161/HYPERTENSIONAHA.117.09260) (PMID:28416585)
Neisius, U., Olson, E., Rossi, S. H., Ibrahim, H. A., Currie, G. , Dominiczak, A. and Delles, C. (2017) Evaluation of the systemic micro- and macrovasculature in stable angina: a case-control study. PLoS ONE, 12(5), e0178412. (doi: 10.1371/journal.pone.0178412) (PMID:28542516) (PMCID:PMC5444845)
Graham, L. A. , Dominiczak, A. and Ferreri, N. R. (2017) The role of renal transporters and novel regulatory interactions in the TAL that control blood pressure. Physiological Genomics, 49(5), pp. 261-276. (doi: 10.1152/physiolgenomics.00017.2017) (PMID:28389525)
Lee, H., Dominiczak, A. F. , Jennings, G. L.R., Cho, E. J. and Lee, H.-Y. (2017) Case of chronic indolent pheochromocytoma that caused medically controlled hypertension but treatment-resistant diabetes mellitus. Hypertension, 69(5), pp. 740-746. (doi: 10.1161/HYPERTENSIONAHA.117.09183) (PMID:28373587)
Amar, L. et al. (2017) Case of primary aldosteronism with discordant hormonal and computed tomographic findings. Hypertension, 69(4), pp. 529-535. (doi: 10.1161/HYPERTENSIONAHA.116.08751) (PMID:28193708)
Dominiczak, A. , Delles, C. and Padmanabhan, S. (2017) Genomics and precision medicine for clinicians and scientists in hypertension. Hypertension, 69(4), e10-e13. (doi: 10.1161/HYPERTENSIONAHA.116.08252) (PMID:28193712)
Menni, C., Metrustry, S. J., Ehret, G., Dominiczak, A. F. , Chowienczyk, P., Spector, T. D., Padmanabhan, S. and Valdes, A. M. (2017) Molecular pathways associated with blood pressure and hexadecanedioate levels. PLoS ONE, 9(4), e0175479. (doi: 10.1371/journal.pone.0175479) (PMID:28403188) (PMCID:PMC5389832)
Miller-Hodges, E., Dominiczak, A. F. , Jennings, G. L.R., Oparil, S., Batlle, D. C., Elijovich, F., Basile, J. N., Laffer, C. L., Oliveras, A. and Dhaun, N. (2017) Hypertension and its complications in a young man with autoimmune disease. Hypertension, 69(4), pp. 536-544. (doi: 10.1161/HYPERTENSIONAHA.117.09036) (PMID:28242716)
Mancia, G. et al. (2017) The technical report on sodium intake and cardiovascular disease in low- and middle-income countries by the joint working group of the World Heart Federation, the European Society of Hypertension and the European Public Health Association. European Heart Journal, 38(10), pp. 712-719. (doi: 10.1093/eurheartj/ehw549) (PMID:28110297)
Carty, D. M., Doogan, F., Welsh, P. , Dominiczak, A. F. and Delles, C. (2017) Thyroid stimulating hormone (TSH) ≥2.5mU/l in early pregnancy: prevalence and subsequent outcomes. European Journal of Obstetrics and Gynecology and Reproductive Biology, 210, pp. 366-369. (doi: 10.1016/j.ejogrb.2017.01.048) (PMID:28153744)
Koh-Tan, H.H. C., Dashti, M., Wang, T., Beattie, W., Mcclure, J. , Young, B., Dominiczak, A. F. , McBride, M. W. and Graham, D. (2017) Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3. Journal of Hypertension, 35(2), pp. 319-329. (doi: 10.1097/HJH.0000000000001155) (PMID:27755386) (PMCID:PMC5214373)
Dominiczak, A. F. and Kuo, D. (2017) Hypertension: update 2017. Hypertension, 61(1), pp. 3-4. (doi: 10.1161/HYPERTENSIONAHA.116.08683) (PMID:27920130)
Salvi, E. et al. (2017) Genome-wide and gene-based meta-analyses identify novel loci influencing blood pressure response to hydrochlorothiazide. Hypertension, 69(1), pp. 51-59. (doi: 10.1161/HYPERTENSIONAHA.116.08267) (PMID:27802415) (PMCID:PMC5145728)
Liu, D. J. et al. (2017) Exome-wide association study of plasma lipids in >300,000 individuals. Nature Genetics, 49, pp. 1758-1766. (doi: 10.1038/ng.3977) (PMID:29083408)
2016
Boal, A. H., Smith, D. J. , Mccallum, L., Muir, S., Touyz, R. M. , Dominiczak, A. F. and Padmanabhan, S. (2016) Monotherapy with major antihypertensive drug classes and risk of hospital admissions for mood disorders. Hypertension, 68(5), pp. 1132-1138. (doi: 10.1161/HYPERTENSIONAHA.116.08188) (PMID:27733585) (PMCID:PMC5058642)
Ehret, G. B. et al. (2016) The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics, 48(10), pp. 1171-1184. (doi: 10.1038/ng.3667) (PMID:27618452) (PMCID:PMC5042863)
Lurbe, E. et al. (2016) 2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents. Journal of Hypertension, 34(10), pp. 1887-1920. (doi: 10.1097/HJH.0000000000001039) (PMID:27467768)
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Touyz, R. M. and Dominiczak, A. F. (2016) Hypertension guidelines: is it time to reappraise blood pressure thresholds and targets? Hypertension, 67(4), pp. 688-689. (doi: 10.1161/hypertensionaha.116.07090) (PMID:26962205)
Lip, S. , Jeemon, P., Mccallum, L., Dominiczak, A. F. , McInnes, G. T. and Padmanabhan, S. (2016) Contrasting mortality risks among subgroups of treated hypertensive patients developing new-onset diabetes. European Heart Journal, 374(12), (doi: 10.1093/eurheartj/ehv557) (PMID:26508167)
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MacIsaac, R., Janek, S., Higgins, P., Walters, M. R. , Padmanabhan, S. , Dominiczak, A. F. , Touyz, R. M. and Dawson, J. (2016) Allopurinol and cardiovascular outcomes in adults with hypertension. Hypertension, 67(3), pp. 535-540. (doi: 10.1161/HYPERTENSIONAHA.115.06344) (PMID:26865199)
Zanchetti, A. et al. (2016) Continuation of the ESH-CHL-SHOT trial after publication of the SPRINT: rationale for further study on blood pressure targets of antihypertensive treatment after stroke. Journal of Hypertension, 34(3), pp. 393-396. (doi: 10.1097/HJH.0000000000000853) (PMID:26780185)
Currie, G. , Delles, C. , Touyz, R. M. , Staessen, J. A., Dominiczak, A. F. , Jennings, G. L. R. and Wang, J.-G. (2016) A woman with treatment-resistant hypertension. Hypertension, 67(2), pp. 243-250. (doi: 10.1161/HYPERTENSIONAHA.115.06756) (PMID:26711735)
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Touyz, R. M. and Dominiczak, A. F. (2016) Successes of SPRINT, but still some hurdles to cross. Hypertension, 67, pp. 268-269. (doi: 10.1161/HYPERTENSIONAHA.115.06725) (PMID:26556815)
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Hunter, R. W., Dominiczak, A. F. , Alwakeel, J., Staessen, J. A., Jennings, G. L.R., Abu-Alfa, A. K., Webb, D. J. and Dhaun, N. (2016) Hypertensive encephalopathy and renal failure in a young man. Hypertension, 67(1), (doi: 10.1161/HYPERTENSIONAHA.115.06651) (PMID:26597825)
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2015
Tomaszewski, M. et al. (2015) Renal mechanisms of association between fibroblast growth factor 1 and blood pressure. Journal of the American Society of Nephrology, (doi: 10.1681/ASN.2014121211) (PMID:25918036)
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Borghi, C., Rosei, E. A., Bardin, T., Dawson, J. , Dominiczak, A. , Kielstein, J. T., Manolis, A. J., Perez-Ruiz, F. and Mancia, G. (2015) Serum uric acid and the risk of cardiovascular and renal disease. Journal of Hypertension, 33(9), pp. 1729-1741. (doi: 10.1097/HJH.0000000000000701) (PMID:26136207)
Menni, C. et al. (2015) Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate. Hypertension, 66, pp. 422-429. (doi: 10.1161/HYPERTENSIONAHA.115.05544) (PMID:26034203) (PMCID:PMC4490909)
Mccallum, L. et al. (2015) Longitudinal blood pressure control, long-term mortality and predictive utility of serum liver enzymes and bilirubin in hypertensive patients. Hypertension, 66(1), pp. 37-43. (doi: 10.1161/HYPERTENSIONAHA.114.04915) (PMID:25941342) (PMCID:PMC4461392)
Wei, W. et al. (2015) Copy number variation in the human Y chromosome in the UK population. Human Genetics, 134(7), pp. 789-800. (doi: 10.1007/s00439-015-1562-5) (PMID:25957587)
Wei, W. et al. (2015) Erratum to: Copy number variation in the human Y chromosome in the UK population. Human Genetics, 134(7), p. 801. (doi: 10.1007/s00439-015-1565-2) (PMID:25986439)
Chittani, M. et al. (2015) TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives. Journal of Hypertension, 33(6), pp. 1301-1309. (doi: 10.1097/HJH.0000000000000541) (PMID:25695618)
Lip, S. , Carlin, C., McCallum, L., Touyz, R.H. , Dominiczak, A.F. and Padmanabhan, S. (2015) Incidence and prognosis of cancer associated with digoxin and common antihypertensive drugs. Journal of Hypertension, 33(Supl 1), e45. (doi: 10.1097/01.hjh.0000467465.54504.ae) (PMID:26102824)
Fulton, R. L., Walters, M. R. , Morton, R., Touyz, R. M. , Dominiczak, A. F. , Morrison, D. S., Padmanabhan, S. , Meredith, P. A., McInnes, G. T. and Dawson, J. (2015) Acetaminophen use and risk of myocardial infarction and stroke in a hypertensive cohort. Hypertension, 65(5), 1008-U596. (doi: 10.1161/HYPERTENSIONAHA.114.04945) (PMID:25801870)
King, D.A. et al. (2015) Mosaic structural variation in children with developmental disorders. Human Molecular Genetics, 24(10), pp. 2733-2745. (doi: 10.1093/hmg/ddv033) (PMID:25634561) (PMCID:PMC4406290)
Kurtz, T.W., Dominiczak, A.F. , DiCarlo, S.E., Pravenec, M. and Morris, R.C. (2015) Molecular-based mechanisms of mendelian forms of salt-dependent hypertension: questioning the prevailing theory. Hypertension, 65(5), pp. 932-941. (doi: 10.1161/HYPERTENSIONAHA.114.05092) (PMID:25753977)
Ravassa, S., Kuznetsova, T., Varo, N., Thijs, L., Delles, C. , Dominiczak, A. , Díez, J. and Staessen, J. A. (2015) Biomarkers of cardiomyocyte injury and stress identify left atrial and left ventricular remodelling and dysfunction: a population-based study. International Journal of Cardiology, 185, pp. 177-185. (doi: 10.1016/j.ijcard.2015.03.046) (PMID:25796005)
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Lucaccioni, L., Wong, S. C. , Smyth, A., Lyall, H., Dominiczak, A. , Ahmed, S. F. and Mason, A. (2015) Turner syndrome-issues to consider for transition to adulthood. British Medical Bulletin, 113(1), pp. 45-58. (doi: 10.1093/bmb/ldu038) (PMID:25533182)
Padmanabhan, S. , Caulfield, M. and Dominiczak, A. (2015) Genetic and molecular aspects of hypertensin. Circulation Research, 116(6), pp. 937-959. (doi: 10.1161/CIRCRESAHA.116.303647) (PMID:25767282)
Tillmann, T., Gibson, A. R., Scott, G., Harrison, O., Dominiczak, A. and Hanlon, P. (2015) Systems medicine 2.0: potential benefits of combining electronic healthcare records with systems science models. Journal of Medical Internet Research, 17(3), e64. (doi: 10.2196/jmir.3082) (PMID:25831125) (PMCID:PMC4387294)
Boal, A., Smith, D. , Muir, S., Touyz, R. M. , Dominiczak, A. F. and Padmanabhan, S. (2015) Antihypertensive therapy and risk of admissions for mood disorders. Journal of Hypertension, 33(Supp 1), e128. (doi: 10.1097/01.hjh.0000467697.82617.32) (PMID:26102733)
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Dominiczak, A. F. and Kuo, D. R.K. (2015) Hypertension: update 2015. Hypertension, 65(1), pp. 3-4. (doi: 10.1161/HYPERTENSIONAHA.114.04842)
Lip, S. , McCallum, L., Touyz, R.H. , Dominiczak, A.F. and Padmanabhan, S. (2015) Clinical implications of the diastolic blood pressure 'J Curve' in treated hypertensive patients. Journal of Hypertension, 33(Supl 1), e87. (doi: 10.1097/01.hjh.0000467584.81358.e3) (PMID:26102953)
Locke, A. E. et al. (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature, 518(7538), pp. 197-206. (doi: 10.1038/nature14177) (PMID:25673413) (PMCID:PMC4382211)
Lopez, L. M. et al. (2015) Genes from a translational analysis support a multifactorial nature of white matter hyperintensities. Stroke, 46(2), pp. 341-347. (doi: 10.1161/STROKEAHA.114.007649) (PMID:25586835) (PMCID:PMC4306534)
Perry, C. G., Freel, E. M., O'Dwyer, P., Schiffrin, E. L., Jennings, G. L., Dominiczak, A. F. and De Buyzere, M. (2015) Rare cause of severe hypertension in a young woman. Hypertension, 65(1), pp. 21-24. (doi: 10.1161/HYPERTENSIONAHA.114.04619) (PMID:25385763)
2014
Mark, P. B., Schiffrin, E. L., Jennings, G. L., Dominiczak, A. F. , Wang, J.-G., De Buyzere, M. and Staessen, J. A. (2014) Renovascular hypertension: to stent or not to stent? Hypertension, 64(6), pp. 1165-1168. (doi: 10.1161/HYPERTENSIONAHA.114.04497)
Herbert, A. et al. (2014) Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors. European Heart Journal, 35(44), pp. 3122-3133. (doi: 10.1093/eurheartj/ehu293) (PMID:25112663)
Beattie, C. J., Fulton, R. L., Higgins, P., Padmanabhan, S. , McCallum, L., Walters, M. R. , Dominiczak, A. F. , Touyz, R. M. and Dawson, J. (2014) Allopurinol initiation and change in blood pressure in older adults with hypertension. Hypertension, 64(5), pp. 1102-1107. (doi: 10.1161/HYPERTENSIONAHA.114.03953) (PMID:25135183)
Sampson, A. K., Mohammed, D., Beattie, W., Graham, D. , Kenyon, C. J., Al-Dujaili, E. A.S., Guryev, V., McBride, M. W. and Dominiczak, A. F. (2014) Introgressed chromosome 2 quantitative trait loci restores aldosterone regulation and reduces response to salt in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 32(10), pp. 2013-2021. (doi: 10.1097/HJH.0000000000000300)
Zanchetti, A. et al. (2014) Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient. Journal of Hypertension, 32(9), pp. 1888-1897. (doi: 10.1097/HJH.0000000000000254) (PMID:24979303)
Arking, D. E. et al. (2014) Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nature Genetics, 46(8), pp. 826-836. (doi: 10.1038/ng.3014) (PMID:24952745) (PMCID:PMC4124521)
Yoneyama, S. et al. (2014) Gene-centric meta-analyses for central adiposity traits in up to 57 412 individuals of European descent confirm known loci and reveal several novel associations. Human Molecular Genetics, 23(9), pp. 2498-2510. (doi: 10.1093/hmg/ddt626)
Tragante, V. et al. (2014) Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. American Journal of Human Genetics, 94(3), pp. 349-360. (doi: 10.1016/j.ajhg.2013.12.016) (PMID:24560520) (PMCID:PMC3951943)
Graham, L. A. et al. (2014) Validation of uromodulin as a candidate gene for human essential hypertension. Hypertension, 63(3), pp. 551-558. (doi: 10.1161/HYPERTENSIONAHA.113.01423)
McLachlan, J., Beattie, E., Murphy, M. P., Koh-Tan, C. H.H., Olson, E., Beattie, W., Dominiczak, A. F. , Nicklin, S. A. and Graham, D. (2014) Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function. Journal of Hypertension, 32(3), pp. 555-564. (doi: 10.1097/HJH.0000000000000054)
Carty, D.M., Neisius, U., Rooney, L.K., Dominiczak, A.F. and Delles, C. (2014) Pulse wave analysis for the prediction of preeclampsia. Journal of Human Hypertension, 28(2), pp. 98-104. (doi: 10.1038/jhh.2013.64)
Mancia, G. et al. (2014) 2013 ESH/ESC practice guidelines for the management of arterial hypertension. Blood Pressure, 23(1), pp. 3-16. (doi: 10.3109/08037051.2014.868629)
Bailey, E. L. , McBride, M. W. , Crawford, W., McClure, J. D. , Graham, D. , Dominiczak, A. F. , Sudlow, C. L.M., Smith, C. and Wardlaw, J. M. (2014) Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke. Neuropathology and Applied Neurobiology, 40(7), pp. 855-872. (doi: 10.1111/nan.12116)
Baud, A. et al. (2014) Genomes and phenomes of a population of outbred rats and its progenitors. Scientific Data, 1, 140011. (doi: 10.1038/sdata.2014.11) (PMID:25977769) (PMCID:PMC4381735)
Dominiczak, A.F. and Fink, G.D. (2014) Celebrating 35 years of success. Hypertension, 63(1), pp. 2-3. (doi: 10.1161/HYPERTENSIONAHA.113.02762)
Holmes, M. V. et al. (2014) Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. British Medical Journal, 349, g4164. (doi: 10.1136/bmj.g4164) (PMID:25011450) (PMCID:PMC4091648)
Holmes, M. V. et al. (2014) Mendelian randomization of blood lipids for coronary heart disease. European Heart Journal, 36(9), pp. 539-550. (doi: 10.1093/eurheartj/eht571) (PMID:24474739) (PMCID:PMC4344957)
McCallum, L. et al. (2014) Response to effect of serum chloride on mortality in hypertensive patients. Hypertension, 63(3), e15-e15. (doi: 10.1161/HYPERTENSIONAHA.113.02926)
Norsworthy, P. J. et al. (2014) Targeted genetic testing for familial hypercholesterolaemia using next generation sequencing: a population-based study. BMC Medical Genetics, 15(1), p. 70. (doi: 10.1186/1471-2350-15-70)
Padmanabhan, S. , Caulfield, M. and Dominiczak, A. F. (2014) Genetic basis of blood pressure and hypertension. In: Mancia, Giuseppe, Grassi, Guido and Redon, Josep (eds.) Manual of Hypertension of the European Society of Hypertension, Second Edition. CRC Press: Boca Raton, FL, pp. 115-128. ISBN 9781841849973 (doi: 10.1201/b17072-13)
Padmanabhan, S. , Graham, L. , Ferreri, N. R., Graham, D. , McBride, M. and Dominiczak, A. (2014) Uromodulin, an emerging novel pathway for blood pressure regulation and hypertension. Hypertension, 64(5), pp. 918-923. (doi: 10.1161/HYPERTENSIONAHA.114.03132)
Sampson, A. K., Andrews, K. L., Graham, D. , McBride, M. W. , Head, G. A., Thomas, M. C., Chin-Dusting, J. P.F., Dominiczak, A. F. and Jennings, G. L. (2014) Origin of the y chromosome influences intrarenal vascular responsiveness to angiotensin i and angiotensin (1-7) in stroke-prone spontaneously hypertensive rats. Hypertension, 64(6), pp. 1376-1383. (doi: 10.1161/HYPERTENSIONAHA.114.03756)
Williamson, C. et al. (2014) Family history of premature cardiovascular disease: blood pressure control and long-term mortality outcomes in hypertensive patients. European Heart Journal, 35(9), pp. 563-570. (doi: 10.1093/eurheartj/eht539)
2013
McCallum, L. et al. (2013) Serum chloride is an independent predictor of mortality in hypertensive patients. Hypertension, 62(5), pp. 836-843. (doi: 10.1161/HYPERTENSIONAHA.113.01793)
Brown, C.E. et al. (2013) Predictors of QTc and QTc prolongation in the generation scotland family study. Journal of Human Hypertension, 27(10), p. 639. (doi: 10.1038/jhh.2013.72)
Mancia, G. et al. (2013) 2013 practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC). Journal of Hypertension, 31(10), pp. 1925-1938. (doi: 10.1097/HJH.0b013e328364ca4c)
Goodson, N.J., Smith, B.H., Hocking, L.J., McGilchrist, M.M., Dominiczak, A.F. , Morris, A., Porteous, D.J. and Goebel, A. (2013) Cardiovascular risk factors associated with the metabolic syndrome are more prevalent in people reporting chronic pain: Results from a cross-sectional general population study. Pain, 154(9), pp. 1595-1602. (doi: 10.1016/j.pain.2013.04.043)
Rossi, S. H. et al. (2013) Impaired renal function impacts negatively on vascular stiffness in patients with coronary artery disease. BMC Nephrology, 14(173), (doi: 10.1186/1471-2369-14-173)
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Aubini è re-Robb, L. et al. (2013) Blood pressure response to patterns of weather fluctuations and effect on mortality. Hypertension, 62(1), pp. 190-196. (doi: 10.1161/HYPERTENSIONAHA.111.00686)
Smith, B. H. et al. (2013) Cohort Profile: Generation Scotland: Scottish Family Health Study (GS:SFHS). The study, its participants and their potential for genetic research on health and illness. International Journal of Epidemiology, 42(3), pp. 689-700. (doi: 10.1093/ije/dys084)
Carty, D.M., Dominiczak, A. and Delles, C. (2013) Pulse wave analysis for prediction of preeclampsia. Endocrine Reviews, 34(3), SAT-520.
MacKenzie, R.M. et al. (2013) Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes. Clinical Science, 124(6), pp. 403-411. (doi: 10.1042/CS20120239)
Guo, Y., Lanktree, M. B., Taylor, K. C., Hakonarson, H., Lange, L. A., Keating, B. J., Padmanabhan, S. , Delles, C. , Dominiczak, A. F. and Hastie, C. (2013) Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Human Molecular Genetics, 22(1), pp. 184-201. (doi: 10.1093/hmg/dds396) (PMID:23001569) (PMCID:PMC3522401)
Alvarez-Madrazo, S. et al. (2013) Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension. Hypertension, 61(1), pp. 232-239. (doi: 10.1161/HYPERTENSIONAHA.112.200741)
Baud, A. et al. (2013) Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nature Genetics, 45(7), pp. 767-775. (doi: 10.1038/ng.2644)
Brittain, J.F. et al. (2013) An MRI-histological study of white matter in stroke-free SHRSP. Journal of Cerebral Blood Flow and Metabolism, 33(5), pp. 760-763. (doi: 10.1038/jcbfm.2013.14)
Dawson, J. et al. (2013) Acetaminophen use and change in blood pressure in a hypertensive population. Journal of Hypertension, 31(7), pp. 1485-1490. (doi: 10.1097/HJH.0b013e328360f6f8)
Dawson, J. et al. (2013) Serum uric acid level, longitudinal blood pressure, renal function, and long-term mortality in treated hypertensive patients. Hypertension, 62(1), pp. 105-111. (doi: 10.1161/HYPERTENSIONAHA.113.00859)
Delles, C. and Dominiczak, A. F. (2013) Metabolic alterations. In: Mancia, G. (ed.) Resistant Hypertension : Epidemiology, Pathophysiology, Diagnosis and Treatment. Springer, pp. 23-37. ISBN 9788847054158 (doi: 10.1007/978-88-470-5415-8_3)
Dominiczak, A. (2013) Hypertension: update 2013. Hypertension, 61(1), p. 2. (doi: 10.1161/HYPERTENSIONAHA.111.00667)
Hastie, C. et al. (2013) Long-term and ultra-long term blood pressure variability during follow–up and mortality in 14522 patients with hypertension. Hypertension, 62(4), pp. 698-705. (doi: 10.1161/HYPERTENSIONAHA.113.01343) (PMID:23959561)
Koh-Tan, H.H. C., McBride, M. W. , McClure, J. D. , Beattie, E., Young, B., Dominiczak, A. F. and Graham, D. (2013) Interaction between chromosome 2 and 3 regulates pulse pressure in the stroke-prone spontaneously hypertensive rat. Hypertension, 62(1), pp. 33-40. (doi: 10.1161/HYPERTENSIONAHA.111.00814)
Mancia, G. et al. (2013) 2013 ESH/ESC guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). European Heart Journal, 34(28), pp. 2159-2219. (doi: 10.1093/eurheartj/eht151)
McDonough, C.W., Gong, Y., Padmanabhan, S. , Burkley, B., Langaee, T.Y., Melander, O., Pepine, C.J., Dominiczak, A.F. , Cooper-DeHoff, R.M. and Johnson, J.A. (2013) Pharmacogenomic association of nonsynonymous SNPs in SIGLEC12, A1BG, and the selectin region and cardiovascular outcomes. Hypertension, 62(1), pp. 48-54. (doi: 10.1161/HYPERTENSIONAHA.111.00823)
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2012
van der Harst, P. et al. (2012) Seventy-five genetic loci influencing the human red blood cell. Nature, 492(7429), pp. 369-375. (doi: 10.1038/nature11677) (PMID:23222517) (PMCID:PMC3623669)
Sanna-Cherchi, S. et al. (2012) Copy-number disorders are a common cause of congenital kidney malformations. American Journal of Human Genetics, 91(6), pp. 987-997. (doi: 10.1016/j.ajhg.2012.10.007)
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MacKenzie, R.M., Sandrim, V.C., Carty, D.M., McClure, J.D. , Freeman, D.J. , Dominiczak, A.F. , McBride, M.W. and Delles, C. (2012) Endothelial FOS expression and pre-eclampsia. BJOG: An International Journal of Obstetrics and Gynaecology, 119(13), pp. 1564-1571. (doi: 10.1111/1471-0528.12016)
Asselbergs, F.W. et al. (2012) Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. American Journal of Human Genetics, 91(5), pp. 823-838. (doi: 10.1016/j.ajhg.2012.08.032)
Paul, L. et al. (2012) Hematocrit predicts long-term mortality in a nonlinear and sex-specific manner in hypertensive adults. Hypertension, 60(3), pp. 631-638. (doi: 10.1161/HYPERTENSIONAHA.112.191510)
Mischak, H. et al. (2012) Implementation of proteomic biomarkers: making it work. European Journal of Clinical Investigation, 42(9), pp. 1027-1036. (doi: 10.1111/j.1365-2362.2012.02674.x) (PMID:22519700) (PMCID:PMC3464367)
Hocking, L.J. et al. (2012) Heritability of chronic pain in 2195 extended families. European Journal of Pain, 16(7), pp. 1053-1063. (doi: 10.1002/j.1532-2149.2011.00095.x)
Carty, D.M., Anderson, L.A., Freeman, D.J. , Welsh, P.I. , Brennand, J.E., Dominiczak, A.F. and Delles, C. (2012) Early pregnancy soluble E-selectin concentrations and risk of preeclampsia. Journal of Hypertension, 30(5), pp. 954-959. (doi: 10.1097/HJH.0b013e328352573b)
Saxena, R. et al. (2012) Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. American Journal of Human Genetics, 90(3), pp. 410-425. (doi: 10.1016/j.ajhg.2011.12.022)
Currie, G. , Freel, E. M., Perry, C. G. and Dominiczak, A. F. (2012) Disorders of blood pressure regulation — role of catecholamine biosynthesis, release, and metabolism. Current Hypertension Reports, 14(1), pp. 38-45. (doi: 10.1007/s11906-011-0239-2)
Carty, D.M., Anderson, L.A., Duncan, C.N., Baird, D., Rooney, L.K., Dominiczak, A.F. and Delles, C. (2012) Peripheral arterial tone: assessment of microcirculatory function in pregnancy. Journal of Hypertension, 30(1), pp. 117-123. (doi: 10.1097/HJH.0b013e32834d76fb)
Charchar, F.J. et al. (2012) Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome. Lancet, 379(9819), pp. 915-922. (doi: 10.1016/S0140-6736(11)61453-0)
Dominiczak, A.F. (2012) Hypertension: update 2012. Hypertension, 59(4), pp. 753-754. (doi: 10.1161/HYP.0b013e31824f9ffe)
Flores, M., Graham, D. , Dominiczak, A.F. , Milligan, G. , Baker, A.H. and Nicklin, S.A. (2012) Angiotensin-(1-9) antagonises Angiotensin II-induced cardiac remodeling via the angiotensin type 2 receptor. Proceedings of the Physiological Society, 27, C1.
Flores, M., Work, L.M. , Douglas, K., Denby, L., Dominiczak, A.F. , Graham, D. and Nicklin, S.A. (2012) Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor. Hypertension, 59(2), pp. 300-307. (doi: 10.1161/HYPERTENSIONAHA.111.177485)
Flores, M., Graham, D. , Dominiczak, A. F. , Milligan, G. , Baker, A. H. and Nicklin, S. A. (2012) Abstract 231: angiotensin-(1-9) antagonises cardiac remodelling in a mouse model of Angiotensin Ii-induced hypertension. Hypertension, 60, A231.
Hamilton, G., Evans, K.L., MacIntyre, D.J., Deary, I.J., Dominiczak, A.F. , Smith, B.H., Morris, A.D., Porteous, D.J. and Thomson, P.A. (2012) Alzheimer's disease risk factor complement receptor 1 is associated with depression. Neuroscience Letters, 510(1), pp. 6-9. (doi: 10.1016/j.neulet.2011.12.059)
Neisius, U. et al. (2012) Association of central and peripheral pulse pressure with intermediate cardiovascular phenoytpes. Journal of Hypertension, 30(1), pp. 67-74. (doi: 10.1097/HJH.0b013e32834e12d8)
Padmanabhan, S. , Newton-Cheh, C. and Dominiczak, A.F. (2012) Genetic basis of blood pressure and hypertension. Trends in Genetics, 28(8), pp. 397-408. (doi: 10.1016/j.tig.2012.04.001)
Padmanabhan, S. and Dominiczak, A. F. (2012) Genetics and hypertension: which information for clinical practice. In: Berbari, Adel E. and Mancia, Giuseppe (eds.) Special Issues in Hypertension. Springer Milan: Milan, pp. 439-452. ISBN 9788847026001 (doi: 10.1007/978-88-470-2601-8_33)
Salvi, E. et al. (2012) Genomewide Association study using a high-density single nucleotide polymorphism array and case-control design identifies a novel essential hypertension susceptibility locus in the promoter region of endothelial NO synthase. Hypertension, 59(2), pp. 248-255. (doi: 10.1161/HYPERTENSIONAHA.111.181990)
2011
Johnson, T. et al. (2011) Blood pressure loci identified with a gene-centric array. American Journal of Human Genetics, 89(6), pp. 688-700. (doi: 10.1016/j.ajhg.2011.10.013)
Ehret, G. B. et al. (2011) Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478(7367), pp. 103-109. (doi: 10.1038/nature10405)
Delles, C. , Diez, J. and Dominiczak, A.F. (2011) Urinary proteomics in cardiovascular disease: achievements, limits and hopes. Proteomics Clinical Applications, 5(5-6), pp. 222-232. (doi: 10.1002/prca.201000125)
Lanktree, M. B. et al. (2011) Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics, 88(1), pp. 6-18. (doi: 10.1016/j.ajhg.2010.11.007)
Bailey, E.L. , Wardlaw, J.M., Graham, D. , Dominiczak, A.F. , Sudlow, C.L.M. and Smith, C. (2011) Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats. Neuropathology and Applied Neurobiology, 37(7), pp. 711-726. (doi: 10.1111/j.1365-2990.2011.01170.x)
Carty, D.M. et al. (2011) Urinary proteomics for prediction of preeclampsia. Hypertension, 57(3), pp. 561-569. (doi: 10.1161/HYPERTENSIONAHA.110.164285)
Denby, L. et al. (2011) miR-21 and miR-214 are consistently modulated during renal injury in rodent models. American Journal of Pathology, 179(2), pp. 661-672. (doi: 10.1016/j.ajpath.2011.04.021)
Dominiczak, A.F. (2011) Replication of genome-wide association studies blood pressure hits in a large cohort. Journal of Hypertension, 29(1), p. 32. (doi: 10.1097/HJH.0b013e328341c6c9)
Menni, C. et al. (2011) Evaluation of How Gene-Job Strain Interaction Affects Blood Pressure in the PAMELA Study. Psychosomatic Medicine, 73(4), pp. 304-309. (doi: 10.1097/PSY.0b013e318212e0be)
Shah, S. et al. (2011) Four genetic loci influencing electrocardiographic indices of left ventricular hypertrophy. Circulation: Cardiovascular Genetics, 4(6), pp. 626-635. (doi: 10.1161/CIRCGENETICS.111.960203)
Soler Artigas, M. et al. (2011) Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function. American Journal of Respiratory and Critical Care Medicine, 184(7), pp. 786-795. (doi: 10.1164/rccm.201102-0192OC)
Yogi, A., Callera, G.E., Aranha, A.B., Antunes, T.T., Graham, D. , McBride, M. , Dominiczak, A. and Touyz, R.M. (2011) Sphingosine-1-Phosphate-Induced Inflammation Involves Receptor Tyrosine Kinase Transactivation in Vascular Cells: Upregulation in Hypertension. Hypertension, 57(4), pp. 809-818. (doi: 10.1161/HYPERTENSIONAHA.110.162719)
2010
Dominiczak, A.F. and Munroe, P.B. (2010) Genome-Wide association studies will unlock the genetic basis of hypertension: Pro side of the argument. Hypertension, 56(6), pp. 1017-1020. (doi: 10.1161/HYPERTENSIONAHA.110.156208)
Greig, J.A., Shirley, R., Graham, D. , Denby, L., Dominiczak, A.F. , Work, L.M. and Baker, A. (2010) Vascular-targeting anti-oxidant therapy in a model of hypertension and stroke. Journal of Cardiovascular Pharmacology, 56(6), pp. 642-650. (doi: 10.1097/FJC.0b013e3181f8f19f)
Hopcroft, L. E.M. , McBride, M. W. , Harris, K. J., Sampson, A. K., McClure, J. D. , Graham, D. , Young, G., Holyoake, T. L., Girolami, M. A. and Dominiczak, A. F. (2010) Predictive response-relevant clustering of expression data provides insights into disease processes. Nucleic Acids Research, 38(20), pp. 6831-6840. (doi: 10.1093/nar/gkq550)
Good, D. M. et al. (2010) Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease. Molecular and Cellular Proteomics, 9(11), pp. 2424-2437. (doi: 10.1074/mcp.M110.001917)
Lango Allen, H. et al. (2010) Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467(7317), pp. 832-838. (doi: 10.1038/nature09410) (PMID:20881960) (PMCID:PMC2955183)
Chambers, J. C. et al. (2010) Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics, 42(5), pp. 373-375. (doi: 10.1038/ng.566)
Craddock, N. et al. (2010) Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature, 464(7289), 713-U86. (doi: 10.1038/nature08979)
Paul, L., Hastie, C. E. , Li, W. S., Harrow, C., Muir, S., Connell, J. M.C., Dominiczak, A. F. , McInnes, G. T. and Padmanabhan, S. (2010) Resting heart rate pattern during follow-up and mortality in hypertensive patients. Hypertension, 55(2), pp. 567-574. (doi: 10.1161/HYPERTENSIONAHA.109.144808)
Carty, D.A., Crichton, L., Alakandy, L., O'Dwyer, P. and Dominiczak, A. (2010) Hypertension in pregnancy:think laterally. European Journal of Obstetrics and Gynecology and Reproductive Biology, 150(2), pp. 220-221. (doi: 10.1016/j.ejogrb.2010.03.005)
Carty, D.M., Delles, C. and Dominiczak, A.F. (2010) Preeclampsia and future maternal health. Journal of Hypertension, 28(7), pp. 1349-1355. (doi: 10.1097/HJH.0b013e32833a39d0)
Delles, C. , Dymott, J.A., Neisius, U., Rocchiccioli, J.P., Bryce, G.J., Moreno Zulategui, M.U., Carty, D.M., Berg, G.A., Hamilton, C.A. and Dominiczak, A.F. (2010) Reduced LDL-cholesterol levels in patients with coronary artery disease are paralelled by improved endothelial function: An observational study in patients from 2003 and 2007. Atherosclerosis, 211(1), pp. 271-277. (doi: 10.1016/j.atherosclerosis.2010.01.014)
Delles, C. , McBride, M.W. , Graham, D. , Padmanabhan, S. and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802(12), pp. 1299-1308. (doi: 10.1016/j.bbadis.2009.12.006)
Delles, C. et al. (2010) Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals. Journal of Hypertension, 28(11), pp. 2316-2322. (doi: 10.1097/HJH.0b013e32833d81b7)
Delles, C. and Dominiczak, A. F. (2010) Redox-related genetic markers of cardiovascular diseases. In: Sauer, H., Shah, A.M. and Laurindo, F.R.M. (eds.) Studies on Cardiovascular Disorders. Series: Oxidative stress in applied basic research and clinical practice. Humana Press, pp. 187-209. ISBN 9781607615996 (doi: 10.1007/978-1-60761-600-9_10)
Dominiczak, A. F. et al. (2010) Systems biology to battle vascular disease. Nephrology Dialysis Transplantation, 25(4), pp. 1019-1022. (doi: 10.1093/ndt/gfq025)
Fairley, S., McClure, J. , Hanlon, N., Irving, R., McBride, M. , Dominiczak, A. and Hunt, E. (2010) Mapping affymetrix microarray probes to the rat genome via a persistent index. International Journal of Knowledge Discovery in Bioinformatics, 1(1), pp. 48-65. (doi: 10.4018/jkdb.2010100204)
Graham, D. , Koh-Tan, H. H. C. and Dominiczak, A. F. (2010) Reduced renal glutathione S-transferase mu type 1 expression in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 28(3), p. 634. (doi: 10.1097/HJH.0b013e328336902d)
Hastie, C. E. , Padmanabhan, S. and Dominiczak, A. F. (2010) Genome-wide association studies of hypertension: light at the end of the tunnel. International Journal of Hypertension, 2010(509581), (doi: 10.4061/2010/509581)
Hastie, C. et al. (2010) Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention. European Heart Journal, 31(2), pp. 222-226. (doi: 10.1093/eurheartj/ehp317)
Lindgren, C.M. et al. (2010) Genome-wide association scan meta-analysis identifies three loci influencing adiposity and fat distribution. PLoS Genetics, 6(4), e1000508. (doi: 10.1371/journal.pgen.1000508)
Liu, J. Z. et al. (2010) Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nature Genetics, 42(5), pp. 436-440. (doi: 10.1038/ng.572)
Luciano, M. et al. (2010) Shared genetic aetiology between cognitive ability and cardiovascular disease risk factors: Generation Scotland's Scottish family health study. Intelligence, 38(3), pp. 304-313. (doi: 10.1016/j.intell.2010.03.002)
Maahs, D.M. et al. (2010) Urinary collagen fragments are significantly altered in diabetes: a link to pathophysiology. PLoS ONE, 5(9), e13051. (doi: 10.1371/journal.pone.0013051) (PMID:20927192) (PMCID:PMC2946909)
McCabe, C. , Gallagher, L., Macrae, I.M., Gsell, W., Graham, D. and Dominiczak, A.F. (2010) Response to letter by Yao (Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats). Stroke, 41(4), E198-E199. (doi: 10.1161/STROKEAHA.109.575704)
Olsen, M.H. et al. (2010) Agreement within Europe about antihypertensive treatment and education – results from the European Society of Hypertension questionnaire. Journal of Hypertension, 28(7), pp. 1593-1594. (doi: 10.1097/HJH.0b013e32833b7b08)
Padmanabhan, S. , Hastie, C. , Prabhakaran, D. and Dominiczak, A.F. (2010) Genomic approaches to coronary artery disease. Indian Journal of Medical Research, 132(5), pp. 567-78.
Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6(10), e1001177. (doi: 10.1371/journal.pgen.1001177)
Padmanabhan, S. et al. (2010) The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study. Journal of Hypertension, 28(3), pp. 465-477. (doi: 10.1097/HJH.0b013e32833594d7)
Rocchiccioli, J.P., McMurray, J.J.V. and Dominiczak, A.F. (2010) Biomarkers in heart failure: a clinical review. Heart Failure Reviews, 15(4), pp. 251-273. (doi: 10.1007/s10741-008-9123-9)
Sotoodehnia, N. et al. (2010) Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nature Genetics, 42(12), pp. 1068-1076. (doi: 10.1038/ng.716)
Taurino, C., Miller, W.H. , McBride, M.W. , McClure, J.D. , Khanin, R., Moreno Zulategui, M.U., Dymott, J., Delles, C. and Dominiczak, A.F. (2010) Gene expression profiling in whole blood of patients with coronary artery disease. Clinical Science, 119(8), pp. 335-343. (doi: 10.1042/CS20100043)
Teslovich, T.M. et al. (2010) Biological, clinical and population relevance of 95 loci for blood lipids. Nature, 466(7307), pp. 707-713. (doi: 10.1038/nature09270)
2009
McCabe, C. , Gallagher, L., Gsell, W., Graham, D. , Dominiczak, A. F. and Macrae, I. M. (2009) Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. Stroke, 40(12), pp. 3864-3868. (doi: 10.1161/STROKEAHA.109.559021)
Talmud, P. et al. (2009) Gene-centric association signals for lipids and apolipoproteins identified via the humanCVD BeadChip. American Journal of Human Genetics, 85(5), pp. 628-642. (doi: 10.1016/j.ajhg.2009.10.014)
Nolte, I. M. et al. (2009) Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. PLoS ONE, 4(7), e6138. (doi: 10.1371/journal.pone.0006138) (PMID:19587794) (PMCID:PMC2704957)
Sõber, S. et al. (2009) Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array. PLoS ONE, 4(6), e6034. (doi: 10.1371/journal.pone.0006034) (PMID:19562039) (PMCID:PMC2699027)
Org, E. et al. (2009) Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. Human Molecular Genetics, 18(12), pp. 2288-2296. (doi: 10.1093/hmg/ddp135)
Newton-Cheh, C. et al. (2009) Genome-wide association study identifies eight loci associated with blood pressure. Nature Genetics, 41(6), pp. 666-676. (doi: 10.1038/ng.361)
Newhouse, S. et al. (2009) Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion. PLoS ONE, 4(4), e5003. (doi: 10.1371/journal.pone.0005003) (PMID:19347040) (PMCID:PMC2661139)
Padmanabhan, S. , Hastie, C. , Sainsbury, C., McBride, M. W. , Connell, J. M. and Dominiczak, A. F. (2009) The cat, the fly and the beetle - why genetics needs a semantic education. International Journal of Semantic Computing, 3(1), pp. 77-90. (doi: 10.1142/S1793351X09000665)
Dominiczak, A. F. , Delles, C. and Padmanabhan, S. (2009) Are isolated populations better for studying genes that predispose to hypertension? Journal of Hypertension, 27(5), pp. 939-940. (doi: 10.1097/HJH.0b013e328329fca3) (PMCID:PMC2709222)
Dominiczak, A. and Webb, R. (2009) David F. Bohr 1915-2008 In memoriam. Journal of Hypertension, 27(3), pp. 660-661.
Graham, D., Huynh, N.N., Hamilton, C.A., Beattie, E.C., Smith, R.A.J., Cocheme, H.M., Murphy, M.P. and Dominiczak, A.F. (2009) Mitochondria-targeted antioxidant MitoQ(10) improves endothelial function and attenuates cardiac hypertrophy. Hypertension, 54(2), 322-U233. (doi: 10.1161/HYPERTENSIONAHA.109.130351)
Johannesson, M. et al. (2009) A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock. Genome Research, 19(1), pp. 150-158. (doi: 10.1101/gr.081497.108)
Koh-Tan, H., Graham, D. , Hamilton, C., Nicoll, G., Fields, L., McBride, M. , Young, B., Young, B. and Dominiczak, A. (2009) Renal and vascular glutathione S-transferase mu is not affected by pharmacological intervention to reduce systolic blood pressure. Journal of Hypertension, 27(8), pp. 1575-1584. (doi: 10.1097/HJH.0b013e32832cc5a1)
Kolz, M. et al. (2009) Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genetics, 5(6), e1000504. (doi: 10.1371/journal.pgen.1000504)
Mancia, G. et al. (2009) Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. Blood Pressure, 18(6), pp. 308-347. (doi: 10.3109/08037050903450468)
Mancia, G. et al. (2009) Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. Journal of Hypertension, 27(11), pp. 2121-2158.
Masson, R. et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53(4), pp. 694-700. (doi: 10.1161/HYPERTENSIONAHA.108.122333)
Mischak, H., Coon, J., Novak, J., Weissinger, E., Schanstra, J. and Dominiczak, A. (2009) Capillary Electrophoresis-Mass Spectrometry As A Powerful Tool in Biomarker Discovery and Clinical Diagnosis: An Update of Recent Developments. Mass Spectrometry Reviews, 28(5), pp. 703-724. (doi: 10.1002/mas.20205)
Padmanabhan, S. , Menni, C., Prabhakaran, D. and Dominiczak, A. (2009) Discovering the genetic determinants of complex diseases. Current Science, 97(3), pp. 385-391.
Tomaszewski, M., Padmanabhan, S. , Miller, W.H., Lee, W.K. and Dominiczak, A.F. (2009) Genetic factors. In: Mancia, G., Grassi, G. and Kjeldsen, S. (eds.) Manual of Hypertension of the European Society of Hypertension. Informa Healthcare: London, pp. 84-93. ISBN 9781841846484
Work, L.M. , Dominiczak, A.F. and McBride, M.W. (2009) The genetic basis of stroke: animal models. In: 3rd Report on Stroke: Genetic research in prevention and in cure. Il Pensiero Scientifico Editore, pp. 219-40.
zur Muhlen, C. et al. (2009) Evaluation of Urine Proteome Pattern Analysis for Its Potential To Reflect Coronary Artery Atherosclerosis in Symptomatic Patients. Journal of Proteome Research, 8(1), pp. 335-345. (doi: 10.1021/pr800615t)
2008
Delles, C., McBride, M.W., Padmanabhan, S. and Dominiczak, A.F. (2008) The genetics of cardiovascular disease. Trends in Endocrinology and Metabolism, 19(9), pp. 309-316. (doi: 10.1016/j.tem.2008.07.010)
Caulfield, M. J. et al. (2008) SLC2A9 is a high-capacity urate transporter in humans. PLoS Medicine, 5(10), e197. (doi: 10.1371/journal.pmed.0050197)
Delles, C. et al. (2008) Glutathione S-transferase variants and hypertension. Journal of Hypertension, 26(7), pp. 1343-1352. (doi: 10.1097/HJH.0b013e3282fe1d67)
Padmanabhan, S. , Melander, O., Hastie, C., Menni, C., Delles, C. , Connell, J. M. and Dominiczak, A. F. (2008) Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols. Journal of Hypertension, 26(7), pp. 1275-1281. (doi: 10.1097/HJH.0b013e3282ff634f)
Delles, C. , Zimmerli, L., McGrane, D. J., Koh-Tan, C. H.H., Pathi, V. L., McKay, A. J., Steedman, T., Dargie, H. J., Hamilton, C. A. and Dominiczak, A. F. (2008) Vascular stiffness is related to superoxide generation in the vessel wall. Journal of Hypertension, 26(5), pp. 946-955.
Berry, C., Zimmerli, L.U., Steedman, T., Foster, J.E., Dargie, H.J., Berg, H.A., Dominiczak, A.F. and Delles, C. (2008) Cardiac magnetic resonance findings predict increased resource utilization in elective coronary artery bypass grafting. Clinical Science, 114(6), pp. 423-430. (doi: 10.1042/CS20070337)
Zimmerli, L.U. et al. (2008) Urinary proteomic biomarkers on coronary artery disease. Molecular and Cellular Proteomics, 7(2), pp. 290-298. (doi: 10.1074/mcp.M700394-MCP200)
Wallace, C. et al. (2008) Genome-wide association study identifies genes for biomarkers of cardiovascular disease: Serum urate and dyslipiclemia. American Journal of Human Genetics, 82(1), pp. 139-149. (doi: 10.1016/j.ajhg.2007.11.001)
Carty, D., Delles, C. and Dominiczak, A. (2008) Novel Biomarkers for Predicting Preeclampsia. Trends in Cardiovascular Medicine, 18(5), pp. 186-194. (doi: 10.1016/j.tcm.2008.07.002)
Coon, J.J. et al. (2008) CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics. Proteomics Clinical Applications, 2(7-8), pp. 964-973. (doi: 10.1002/prca.200800024)
Delles, C. , Miller, W. H. and Dominiczak, A. F. (2008) Targeting reactive oxygen species in hypertension. Antioxidants and Redox Signaling, 10(6), pp. 1061-1077. (doi: 10.1089/ars.2007.2008)
Dymott, J.A., Chow, C., Rocchiccioli, J.P., Berg, G.A., Cherry, A.K.L., Delles, C. , Hamilton, C.A. and Dominiczak, A.F. (2008) Endothelial function in patients undergoing coronary artery by-pass grafting is improved in patients in 2006 compared to 2003. Scottish Medical Journal, 53(1), p. 57.
Hastie, C., Padmanabhan, S., Slack, R., Dominiczak, A. and Pell, J. (2008) Factors that predict survival following Percutaneous coronary intervention in patients with and without hypertension. Journal of Hypertension, 26, S113-S113.
Miller, W., Graham, D., Douglas, K., MacKenzie, R. and Dominiczak, A. (2008) Metabolic phenotypes in SHRSP and chromosome 2 congenic strains. Journal of Human Hypertension, 22(10), pp. 736-737.
Miller, W., Graham, D. , Douglas, K., Mackenzie, R., Huynh, N. and Dominiczak, A. (2008) Characterisation of metabolic phenotypes in the SHRSP using chromosome 2 congenic strains. Journal of Hypertension, 26(Suppl.), S340-S341.
Padmanabhan, S. , Menni, C., Lee, W., Brambilla, P., Laing, S., Sega, R., Cesana, G., Mancia, G. and Dominiczak, A. (2008) Cardiovascular gene centric association study of metabolic syndrome and ambulatory blood pressure in the PAMELA study. Journal of Hypertension, 26, S18-S18.
Tian, T., McBride, M.W., Graham, D., Touyz, R. and Dominiczak, A.F. (2008) A systems biology approach for the sphingosine-1-phosphate signal transduction in vascular smooth muscle cell. Journal of Hypertension, 26(Suppl.), S148-S148.
Tonyz, R., Aranha, A., Yogi, A., Graham, D., McBride, M., Callera, G., Montezano, A., Coimbra, T. and Dominiczak, A. (2008) Increased vascular sphingosine-1-phosphate signaling in SHRSP is due to post-receptor mechanisms. Journal of Hypertension, 26(Suppl.), S329-S329.
Weedon, M. et al. (2008) Genome-wide association analysis identifies 20 loci that influence adult height. Nature Genetics, 40(5), pp. 575-583.
2007
Freel, E.M. et al. (2007) Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study. Clinical Endocrinology, 67(6), pp. 832-838. (doi: 10.1111/j.1365-2265.2007.02971.x)
Lee-Kirsch, M. A. et al. (2007) Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nature Genetics, 39(9), pp. 1065-1067. (doi: 10.1038/ng2091) (PMID:17660818)
Barr, M. et al. (2007) Polymorphic variation in the 11 beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency. Hypertension, 49(1), pp. 113-119. (doi: 10.1161/01.HYP.0000249904.93940.7a)
Burton, P.R. et al. (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature, 447(7145), pp. 661-678. (doi: 10.1038/nature05911)
Burton, P. R. et al. (2007) Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nature Genetics, 39(11), pp. 1329-1337. (doi: 10.1038/ng.2007.17)
Chow, C., Pell, A., Walker, A., O'Dowd, C., Dominiczak, A. and Pell, J. (2007) Families of patients with premature coronary heart disease: an obvious but neglected target for primary prevention. British Medical Journal, 335(7618), pp. 481-485. (doi: 10.1136/bmj.39253.577859.BE)
Good, D., Thongboonkerd, V., Novak, J., Bascands, J., Schanstra, J., Coon, J., Dominiczak, A. and Mischak, H. (2007) Body fluid proteomics for biomarker discovery: lessons from the past hold the key to success in the future. Journal of Proteome Research, 6(12), pp. 4549-4555. (doi: 10.1021/pr070529w)
Graham, D. et al. (2007) Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat - Congenic analysis. Hypertension, 50(6), pp. 1134-1141. (doi: 10.1161/HYPERTENSIONAHA.107.095349)
Jakubowska, J., Hunt, E., Chalmers, M., McBride, M. and Dominiczak, A. F. (2007) VisGenome: visualization of single and comparative genome representations. Bioinformatics, 23(19), pp. 2641-2642. (doi: 10.1093/bioinformatics/btm394)
Mancia, G. et al. (2007) [ESH/ESC 2007 Guidelines for the management of arterial hypertension]. Rev Esp Cardiol, 60(9), pp. 968-994.
Mancia, G. et al. (2007) 2007 ESH-ESC Guidelines for the management of arterial hypertension: the task force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Blood Pressure, 16(3), pp. 135-232. (doi: 10.1080/08037050701461084)
Mancia, G. et al. (2007) 2007 Guidelines for the management of arterial hypertension - The task force for the management of arterial hypertension of the European society of hypertension (ESH) and of the European society of cardiology (ESC). European Heart Journal, 28(12), pp. 1462-1536. (doi: 10.1093/eurheartj/ehm236)
Mancia, G. et al. (2007) 2007 ESH-ESC practice guidelines for the management of arterial hypertension - ESH-ESC task force on the management of arterial hypertension. Journal of Hypertension, 25(9), pp. 1751-1762. (doi: 10.1097/HJH.0b013e3282f0580f)
Mancia, G. et al. (2007) [Practice guidelines 2007 for the treatment of arterial hypertension]. Giornale Italiano di Cardiologia, 8(7), pp. 389-479.
Marcano, A. C. B. et al. (2007) Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension. Journal of Medical Genetics, 44(9), pp. 603-605. (doi: 10.1136/jmg.2007.049718)
Nawrot, T., Staessen, J., Roels, H., Den Hond, E., Thijs, L., Fagard, R., Dominiczak, A. and Struijker-Boudier, H. (2007) Blood pressure and blood selenium: a cross-sectional and longitudinal population study. European Heart Journal, 28(5), pp. 628-633. (doi: 10.1093/eurheartj/ehl479)
Newhouse, S. et al. (2007) Association of the WNK1 gene with essential hypertension, blood pressure variability and serum and urine electrolytes. Journal of Human Hypertension, 21(10), p. 831.
Newhouse, S. et al. (2007) Novel associations of the Wnk1 gene with risk for essential hypertension and electrolyte homeostasis. Circulation Research, 101(11), p. 1208.
Padmanabhan, S. et al. (2007) Association of the CYP11B1 and CYP11B2 gene polymorphisms with hypertension in the British Genetics of Hypertension case-control study. Journal of Human Hypertension, 21(10), p. 837.
Padmanabhan, S. et al. (2007) Urinary albumin excretion in hypertensive siblings in the British Genetics of Hypertension study. Journal of Human Hypertension, 21(10), p. 843.
Shankar, R., Charchar, F., Eckert, G., Saha, C., Tu, W., Dominiczak, A. and Pratt, J. (2007) Studies of an association in boys of blood pressure and the Y chromosome. American Journal of Hypertension, 20(1), pp. 27-31. (doi: 10.1016/j.amjhyper.2006.06.013)
Tomaszewski, M., Charchar, F., Lynch, M., Padmanabhan, S. , Wang, W., Miller, W., Grzeszczak, W., Maric, C., Zukowska-Szczechowska, E. and Dominiczak, A. (2007) Fibroblast growth factor 1 gene and hypertension - From the quantitative trait locus to positional analysis. Circulation, 116(17), pp. 1915-1924. (doi: 10.1161/CIRCULATIONAHA.107.710293)
Tomaszewski, M., Charchar, F., Maric, C., McClure, J. , Crawford, L., Grzeszczak, W., Sattar, N. , Zukowska-Szczechowska, E. and Dominiczak, A. (2007) Glomerular hyperfiltration: A new marker of metabolic risk. Kidney International, 71(8), pp. 816-821. (doi: 10.1038/sj.ki.5002160)
Wallace, C. et al. (2007) Discovery of novel genes for serum urate and low-density lipoprotein cholesterol - Two biomarkers of cardiovascular disease. Circulation Research, 101(11), p. 1208.
Zimmerli, L., Mark, P., Steedman, T., Foster, J., Berg, G., Dargie, H., Jardine, A., Delles, C. and Dominiczak, A. (2007) Vascular function in patients with end-stage renal disease and/or coronary artery disease: A cardiac magnetic resonance imaging study. Kidney International, 71(1), pp. 68-73. (doi: 10.1038/sj.ki.5002024)
2006
Al Benna, S., Hamilton, C.A., McClure, J.D. , Rogers, P.N., Berg, G.A., Ford, I. , Delles, C. and Dominiczak, A.F. (2006) Low-density lipoprotein cholesterol determines oxidative stress and endothelial dysfunction in saphenous veins from patients with coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(1), pp. 218-223. (doi: 10.1161/01.ATV.0000193626.22269.45)
Bell, J. et al. (2006) Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension. Human Molecular Genetics, 15(8), pp. 1365-1374. (doi: 10.1093/hmg/ddl058)
Brosnan, M.J. and Dominiczak, A.F. (2006) Common diseases, Genetics. In: Ganten, D. and Ruckpaul, K. (eds.) Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine [vol. 1(3)]. Springer. ISBN 9783540442448
Delles, C. and Dominiczak, A. (2006) Vascular failure or sick vessel syndrome: The cardiovascular continuum is a useful concept for clinical research. Journal of Hypertension, 24(11), pp. 2147-2148. (doi: 10.1097/01.hjh.0000249687.43123.d2)
Delles, C. et al. (2006) Variants of the human mu type glutathione-s-transferase (GSTM) gene family are associated with hypertension. Journal of Hypertension, 24, S13-S13.
Hamilton, C., Groves, S., Carswell, H., Brosnan, M., Graham, D. and Dominiczak, A. (2006) Estrogen treatment enhances nitric oxide bioavailability in normotensive but not hypertensive rats. American Journal of Hypertension, 19(8), pp. 859-866. (doi: 10.1016/j.amjhyper.2006.01.008)
Ibrahim, J., McGee, A., Graham, D., McGrath, J.C. and Dominiczak, A.F. (2006) Sex-specific differences in cerebral arterial myogenic tone in hypertensive and normotensive rats. American Journal of Physiology: Heart and Circulatory Physiology, 290(3), H1081-H1089. (doi: 10.1152/ajpheart.00752.2005)
McBride, M. , Graham, D., Delles, C. and Dominiczak, A. (2006) Functional genomics in hypertension. Current Opinion in Nephrology and Hypertension, 15(2), pp. 145-151. (doi: 10.1097/01.mnh.0000203188.57513.3f)
Munroe, P. et al. (2006) Increased support for linkage of a novel locus on chromosome 5q13 for essential hypertension in the British genetics of hypertension study. Hypertension, 48(1), pp. 105-111. (doi: 10.1161/01.HYP.0000228324.74255.f1)
Padmanabhan, S. et al. (2006) Genomewide linkage analysis for loci affecting electrocardiographic LV mass. Journal of Hypertension, 24, S330-S330.
Padmanabhan, S. et al. (2006) Chromosome 2p shows significant linkage to antihypertensive response in the British genetics of hypertension study. Hypertension, 47(3), pp. 603-608. (doi: 10.1161/01.HYP.0000197947.62601.9d)
Smith, B.H. et al. (2006) Generation Scotland: the Scottish family health study; a new resource for researching genes and heritability. BMC Medical Genetics, 7, p. 74. (doi: 10.1186/1471-2350-7-74)
Tomaszewski, M., Moreno, M., Charchar, F., Zukowska-Szczechowska, E. and Dominiczak, A. (2006) Functional significance of single nucleotide polymorphisms within the 5'-flanking region of beta2-adrenergic receptor gene. Journal of Hypertension, 24(12), pp. 2473-2474. (doi: 10.1097/01.hjh.0000251911.46664.51)
Tomaszewski, M., Zimmerli, L., Charchar, F. and Dominiczak, A. (2006) Genetic information in the diagnosis and treatment of hypertension. Current Hypertension Reports, 8(4), pp. 309-316. (doi: 10.1007/s11906-006-0070-3)
Tomaszewski, M., Brain, N. J. R., Charchar, F. J. and Dominiczak, A. F. (2006) Genetics of human essential hypertension - from single mutations to quantitative trait loci. In: Re, R.N., Di Pette, D.J., Schiffrin, E. and Sowers, J.R. (eds.) Molecular Mechanisms of Hypertension. Taylor & Frances Medical, pp. 241-248. ISBN 9781842143049
Wallace, C. et al. (2006) Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension. American Journal of Human Genetics, 79(2), pp. 323-331. (doi: 10.1086/506370)
2005
Jakubowska, J., Hunt, E., Chalmers, M. , Leader, D. , McBride, M. and Dominiczak, A. F. (2005) System level visualization of eQTLs and pQTLs. BMC Bioinformatics, 6(Sup 3), P15. (doi: 10.1186/1471-2105-6-S3-P15)
Tomaszewski, M., Charchar, F.J., Zukowska-Szczechowska, E., Grzeszczak, W. and Dominiczak, A.F. (2005) Letter re: Inflammation and lipoprotein changes with protracted exercise. Journal of Clinical Endocrinology and Metabolism, 90(8), p. 4981. (doi: 10.1210/jc.2005-1064)
Brain, N.J.R. and Dominiczak, A.F. (2005) Pharmacogenomics in hypertension: present practicalities and future potential. Journal of Hypertension, 23(7), pp. 1327-1329.
Carswell, H., Dominiczak, A. , Garcia-Segura, L., Harada, N., Hutchison, J. and Macrae, I. (2005) Brain aromatase expression after experimental stroke: Topography and time course. Journal of Steroid Biochemistry and Molecular Biology, 96(1), pp. 89-91. (doi: 10.1016/j.jsbmb.2005.02.016)
Carswell, H., McBride, M., Graham, D., Dominiczak, A. and Macrae, I. (2005) Mutant animal models of stroke and gene expression: the stroke-prone spontaneously hypertensive rat. In: Read, SJ and Virley, D (eds.) Stroke Genomics. Series: Methods in Molecular Medicine (104). Humana Press, pp. 49-74. ISBN 978-1-58829-333-6 (doi: 10.1385/1-59259-836-6:049)
Collison, M., James, D., Graham, D., Holman, G., Connell, J., Dominiczak, A.F., Gould, G. and Salt, I. (2005) Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats. Diabetologia, 48(3), pp. 539-546. (doi: 10.1007/s00125-005-1674-x)
Dominiczak, A. F., Graham, D. , McBride, M. W. , Brain, N. J.R., Lee, W. K. , Charchar, F. J., Tomaszewski, M., Delles, C. and Hamilton, C. A. (2005) Corcoran Lecture. Cardiovascular genomics and oxidative stress. Hypertension, 45(4), pp. 636-642. (doi: 10.1161/01.HYP.0000154253.53134.09)
Dominiczak, A. (2005) Disentangling fetal and maternal susceptibility for pre-eclampsia: a British multicenter candidate-gene study. American Journal of Human Genetics, 77(1), pp. 127-131. (doi: 10.1086/431245)
Graham, D., McBride, M., Brain, N. and Dominiczak, A. (2005) Congenic/consomic models of hypertension. In: Fennell, J.P. and Baker, A.H. (eds.) Hypertension. Series: Methods in Molecular Medicine (108). Humana Press, pp. 3-15. ISBN 978-1-58829-323-7 (doi: 10.1385/1-59259-850-1:003)
McBride, M. et al. (2005) Reduction of Gstm1 expression in the stroke-prone spontaneously hypertension rat contributes to increased oxidative stress. Hypertension, 45(4), pp. 786-792. (doi: 10.1161/01.HYP.0000154879.49245.39)
McCallum, R., Sainsbury, C., Spiers, A., Dominiczak, A., Petrie, J. , Sattar, N. and Connell, J. (2005) Growth hormone replacement reduces C-reactive protein and large-artery stiffness but does not alter endothelial function in patients with adult growth hormone deficiency. Clinical Endocrinology, 62(4), pp. 473-479. (doi: 10.1111/j.1365-2265.2005.02245.x)
McCallum, R., Hamilton, C., Graham, D., Jardine, E., Connell, J. and Dominiczak, A. (2005) Vascular responses to IGF-I and insulin are impaired in aortae of hypertensive rats. Journal of Hypertension, 23(2), pp. 351-358.
McGill, J.K., Gallagher, L., Carswell, H.V.O., Irving, E.A., Dominiczak, A.F. and Macrae, I.M. (2005) Impaired functional recovery after stroke in the stroke-prone spontaneously hypertensive rat. Stroke, 36(1), pp. 135-141. (doi: 10.1161/01.STR.0000149629.32525.b7)
Miller, W. , Brosnan, M.J., Graham, D., Nicol, C.G., Morecroft, I., Channon, K.M., Danilov, S.M., Reynolds, P.N., Baker, A.H. and Dominiczak, A.F. (2005) Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats. Molecular Therapy, 12(2), pp. 321-327. (doi: 10.1016/j.ymthe.2005.02.025)
Miller, W.H. , Nicklin, S.A. , Baker, A.H. and Dominiczak, A. (2005) Gene transfer and cardiovascular system. In: Raizada, M.K., Paton, J.F.R., Kasparov, S. and Katovich, M.J. (eds.) Cardiovascular Genomics. Series: Contemporary cardiology. Humana Press: Totowa, NJ, USA, pp. 175-196. ISBN 9781588294005
Nemoto, K. et al. (2005) No involvement of the nerve growth factor gene locus in hypertension in spontaneously hypertensive rats. Hypertension Research, 28(2), pp. 155-163. (doi: 10.1291/hypres.28.155)
Newhouse, S. et al. (2005) Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. Human Molecular Genetics, 14(13), pp. 1805-1814. (doi: 10.1093/hmg/ddi187)
Padmanabhan, S., Munroe, P.B., Brown, M., Clayton, D., Farrall, M., Webster, J., Lathrop, M., Caulfield, M., Dominiczak, A.F. and Connell, J. (2005) Chromosome 2p shows genome wide significant linkage to anti-hypertensive medication response in the British genetics hypertension (BRIGHT) study. Hypertension, 46(4), p. 886.
Strahorn, P., Graham, D., Charchar, F., Sattar, N. , McBride, M. and Dominiczak, A. (2005) Genetic determinants of metabolic syndrome components in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 23(12), pp. 2179-2186.
2004
McBride, M.W. , Charchar, F.J., Graham, D. , Miller, W.H. , Strahorn, P., Carr, F.J. and Dominiczak, A.F. (2004) Functional genomics in rodent models of hypertension. Journal of Physiology, 554(1), pp. 56-63. (doi: 10.1113/jphysiol.2003.049361)
Antier, D., Carswell, H., Brosnan, M., Hamilton, C., Macrae, I., Groves, S., Jardine, E., Reid, J. and Dominiczak, A. (2004) Increased levels of superoxide in brains from old female rats. Free Radical Research, 38(2), pp. 177-183. (doi: 10.1080/10715760310001643294)
Carswell, H.V., Bingham, D., Wallace, K., Nilsen, M., Graham, D.I., Dominiczak, A.F. and Macrae, I.M. (2004) Differential effects of 17beta-estradiol upon stroke damage in stroke prone and normotensive rats. Journal of Cerebral Blood Flow and Metabolism, 24(3), pp. 298-304. (doi: 10.1097/01.WCB.0000112322.75217.FD)
Charchar, F., Padmanabhan, S. , Anderson, N.H., Tomaszewski, M., Upton, M.N., McConnachie, A. , Connell, J.M., Watt, G.C.M., Dominiczak, A.F. and Charchar, F.J. (2004) Y chromsome variant is a predictor of cardiovascular mortality. Journal of Hypertension: Supplement, 22(S1), S58-S59.
Charchar, F.J., Tomaszewski, M., Lacka, B., Zakrzewski, J., Zukowska-Szczechowska, E., Grzeszczak, W. and Dominiczak, A.F. (2004) Association of the human Y chromosome with cholesterol levels in the general population. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(2), pp. 308-312. (doi: 10.1161/01.ATV.0000113291.39267.0a)
Dominiczak, A. , Brain, N., Charchar, F., McBride, M. , Hanlon, N. and Lee, W. (2004) Genetics of hypertension: Lessons learnt from Mendelian and polygenic syndromes. Clinical and Experimental Hypertension, 26(7-8), pp. 611-620. (doi: 10.1081/CEH-200031939)
Graham, D., Hamilton, C., Beattie, E., Spiers, A. and Dominiczak, A. (2004) Comparison of the effects of omapatrilat and irbesartan hydrochlorothiazide on endothelial function and cardiac hypertrophy in the stroke-prone spontaneously hypertensive rat: sex differences. Journal of Hypertension, 22(2), pp. 329-337. (doi: 10.1097/01.hjh.0000098240.58662.93)
Graham, D., Hamilton, C., Beattie, E., Spiers, A. and Dominiczak, A.F. (2004) Comparison of the effects of omapatrilat and irbesartan/hydrochlorothiazide on endothelial function and cardiac hypertrophy in the stroke-prone spontaneously hypertensive rat: sex differences. Journal of Hypertension, 22(2), pp. 329-337.
Hamilton, C., Miller, W., Al Benna, S., Brosnan, M., Drummond, R., McBride, M. and Dominiczak, A. (2004) Strategies to reduce oxidative stress in cardiovascular disease. Clinical Science, 106, pp. 219-234. (doi: 10.1042/CS20030379)
Hunt, E., Hanlon, N., Leader, D.P., Bryce, H. and Dominiczak, A.F. (2004) The visual language of synteny. OMICS: A Journal of Integrative Biology, 8(4), pp. 289-305. (doi: 10.1089/omi.2004.8.289.)
Kuznetsova, T. et al. (2004) Relationship between left ventricular mass and the ACE D/I polymorphism varies according to sodium intake. Journal of Hypertension, 22(2), pp. 287-295.
Newhouse, S. et al. (2004) No association of the WNK1 gene with essential hypertension in the MRC BRIGHT study. Journal of Hypertension, 22, S212-S212.
Padmanabhan, S. , Connell, J.M.C., Dominiczak, A.F. , Inglis, G., Macfarlane, P.W. and Watt, G. (2004) Heritability and genetic determinants of electrocardiographic measures of left ventricular mass - a two generation family study. Journal of Hypertension: Supplement, 22(S1), S180-S181.
Sinnott, R.O. et al. (2004) Grid services supporting the usage of secure federated, distributed biomedical data. In: Proceedings of UK e-Science All Hands Meeting, Nottingham, UK, 31 Aug - 3 Sept 2004,
Tomaszewski, M., Charchar, F., Crawford, L., Zukowska-Sczechowska, E., Grzeszczak, W., Sattar, N. and Dominiczak, A. (2004) Serum C-reactive protein and lipids in ultra-marathon runners. American Journal of Cardiology, 94(1), pp. 125-126. (doi: 10.1016/j.amjcard.2004.03.043)
Tomaszewski, M., Charchar, F., Lacka, B., Pesonen, U., Wang, W., Zukowska-Szczechowska, E., Grzeszczak, W. and Dominiczak, A. (2004) Epistatic interaction between beta2-adrenergic receptor and neuropeptide Y genes influences LDL-cholesterol in hypertension. Hypertension, 44(5), pp. 689-694. (doi: 10.1161/01.HYP.0000143844.81979.61)
2003
Stanton, T., Payne, J.R., Montgomery, H.E., Watt, G., Dominiczak, A.F. , Jardine, A.G. and Connell, J.M. (2003) Genetic determinants of left ventricular mass: the role of beta-1 adrenoceptor variation in normal, athletic, and disease populations. Journal of the American College of Cardiology, 41(6 (S1)), p. 273. (doi: 10.1016/S0735-1097(03)82282-9)
Brown, M., Cruickshank, J., Dominiczak, A. , MacGregor, G., Poulter, N., Russell, G., Thom, S. and Williams, B. (2003) Better blood pressure control: how to combine drugs. Journal of Human Hypertension, 17, pp. 81-86. (doi: 10.1038/sj.jhh.1001511)
Caulfield, M. et al. (2003) Genome-wide mapping of human loci for essential hypertension. Lancet, 361(9375), pp. 2118-2123. (doi: 10.1016/S0140-6736(03)13722-1)
Charchar, F., Tomaszewski, M., Strahorn, P., Champagne, B. and Dominiczak, A. (2003) Y is there a risk to being male? Trends in Endocrinology and Metabolism, 14, pp. 163-168. (doi: 10.1016/S1043-2760(02)00032-8)
Dominiczak, A.F. and McBride, M.W. (2003) Genetics of common polygenic stroke. Nature Genetics, 35(2), pp. 116-117.
Izzard, A.S., Graham, D., Burnham, M.P., Heerkens, E.H., Dominiczak, A.F. and Heagerty, A.M. (2003) Myogenic and structural properties of cerebral arteries from the stroke-prone spontaneously hypertensive rat. American Journal of Physiology: Heart and Circulatory Physiology, 285, H1489-H1494. (doi: 10.1152/ajpheart.00352.2003)
Khan, I.Y., Taylor, P.D., Dekou, V., Seed, P.T., Lakasing, L., Graham, D., Dominiczak, A.F. , Hanson, M.A. and Poston, L. (2003) Gender-linked hypertension in offspring of lard-fed pregnant rats. Hypertension, 41(1), pp. 168-175.
Khan, L., Taylor, P., Dekou, V., Seed, P., Lakasing, L., Graham, D., Dominiczak, A. , Hanson, M. and Poston, L. (2003) Gender-linked hypertension in offspring of lard-fed pregnant rat. Hypertension, 41, pp. 168-175. (doi: 10.1161/01.HYP.0000047511.97879.FC)
McBride, M. , Carr, F., Graham, D., Anderson, N., Clark, J., Lee, W., Charchar, F., Brosnan, M. and Dominiczak, A. (2003) Microarray analysis of rat chromosome 2 congenic strains. Hypertension, 41, pp. 847-853. (doi: 10.1161/01.HYP.0000047103.07205.03)
Pell, J., Smith, G., Dominiczak, A., Cobbe, S., Dobbie, R., McMahon, A. and Ford, I. (2003) Family history of premature death from ischaemic heart disease is associated with an increased risk of delivering a low birth weight baby. Heart, 89(10), pp. 1249-1250. (doi: 10.1136/heart.89.10.1249)
Stanton, T., Robb, S., Payne, J., Montgomery, H., Watt, G., McDonagh, T., Dominiczak, A. , Connell, J. and Dargie, H. (2003) The effect of beta-1 adrenoceptor genetic variation on left ventricular mass. Circulation, 108(17), p. 180.
Tomaszewski, M., Charchar, F.J., Padmanabhan, S. , Zukowska-Szczechowska, E., Grzeszczak, W. and Dominiczak, A.F. (2003) Cardiovascular diseases and G-protein beta 3 subunit gene (GNB3) in the era of genomewide scans. Journal of Human Hypertension, 17(6), pp. 379-380. (doi: 10.1038/sj.jhh.1001559)
Tomaszewski, M. et al. (2003) Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity - How low can you go? Arteriosclerosis, Thrombosis, and Vascular Biology, 23(9), pp. 1640-1644. (doi: 10.1161/01.ATV.0000087036.75849.0B)
2002
Tomaszewski, M. et al. (2002) Essential hypertension and beta(2)-adrenergic receptor gene linkage and association analysis. Hypertension, 40(3), pp. 286-291. (doi: 10.1161/01.HYP.0000029105.21202.FE)
Duncan, A. C., Petrie, J. R. , Brosnan, M. J., Devlin, A. M., Bass, R. A., Charnock-Jones, D. S., Connell, J. M., Dominiczak, A. F. and Lumsden, M. A. (2002) Is estradiol cardioprotection a nitric oxide-mediated effect? Human Reproduction, 17(7), pp. 1918-1924. (doi: 10.1093/humrep/17.7.1918)
Anderson, N.H. and Dominiczak, A.F. (2002) Genetic analysis of complex traits. In: Rimoin, D.l., Connor, J.M. and Pyeritz, R.E. (eds.) Emery and Rimoin's Principles and Practice of Medical Genetics [4th ed.]. Harcourt Brace, pp. 410-424. ISBN 9780443064340
Brosnan, M., Hamilton, C., Graham, D., Lygate, C., Jardine, E. and Dominiczak, A. (2002) Irbesartan lowers superoxide levels and increases nitric oxide bioavailability in blood vessels from spontaneously hypertensive stroke-prone rats. Journal of Hypertension, 20(2), pp. 281-286.
Carr, F.J., Negrin, C.D., Clark, J.S., Graham, D., McBride, M.W. , Anderson, N.W. and Dominiczak, A.F. (2002) Chromosome 2 reciprocal congenic strains to evaluate the effect of the genetic background on blood pressure. Scottish Medical Journal, 47(1), pp. 7-9. (doi: 10.1177/003693300204700104)
Carr, F., McBride, M. , Carswell, H., Graham, D., Strahorn, P., Clark, J., Charchar, F. and Dominiczak, A. (2002) Genetic aspects of stroke: Human and experimental studies. Journal of Cerebral Blood Flow and Metabolism, 22(7), pp. 767-773. (doi: 10.1097/00004647-200207000-00001)
Caulfield, M. et al. (2002) The MRC British Genetics of Hypertension Study - Genome-wide screen results. Journal of Hypertension, 20, S7-S7.
Charchar, F.J. et al. (2002) The Y chromosome effect on blood pressure in two European populations. Hypertension, 39(2), pp. 353-356. (doi: 10.1161/hy0202.103413)
Fennell, J.P., Brosnan, M.J., Frater, A.J. and Dominiczak, A.F. (2002) Gene therapy for hypertension : future or fiction? In: Doevendans, P.A. and Kaab, S. (eds.) Cardiovascular Genomics : New Pathophysiological Concepts. Series: Developments in cardiovascular medicine (242). Springer, pp. 65-75. ISBN 9781461353478 (doi: 10.1007/978-1-4615-1005-5_7)
Fennell, J., Brosnan, M., Frater, A., Hamilton, C., Alexander, M., Nicklin, S., Heistad, D., Baker, A. and Dominiczak, A. (2002) Adenovirus-mediated overexpression of extracellular superoxide dismutase improves endothelial dysfunction in a rat model of hypertension. Gene Therapy, 9(2), pp. 110-117. (doi: 10.1038/sj.gt.3301633)
Hamilton, C., O'Dowd, G., McIntosh, L., Berg, G., Butler, J., Pathi, V., Williams, R., Reid, J. and Dominiczak, A. (2002) Vasorelaxant properties of isolated human radial arteries: comparison with internal mammary arteries. Atherosclerosis, 160(2), pp. 345-353. (doi: 10.1016/S0021-9150(01)00605-0)
Hamilton, C., Brosnan, M., Al Benna, S., Berg, G. and Dominiczak, A. (2002) NAD(P)H oxidase inhibition improves endothelial function in rat and human blood vessels. Hypertension, 40(5), pp. 755-762. (doi: 10.1161/01.HYP.0000037063.90643.0B)
McBride, M. , Carswell, H., Graham, D., Carr, F., Charchar, F., Macrae, I. and Dominiczak, A. (2002) Genetic and gender determinants of cerebrovascular disease. Seminars in Nephrology, 22, pp. 127-134. (doi: 10.1053/snep.2002.30213)
McCallum, R., Petrie, J. , Dominiczak, A. and Connell, J. (2002) Growth hormone deficiency and vascular risk. Clinical Endocrinology, 57(1), pp. 11-24. (doi: 10.1046/j.1365-2265.2002.01559.x)
McCallum, R.W., Hamilton, C., Graham, D., Jardine, E., Dominiczak, A.F. and Connell, J. (2002) Hypertensive but not normotensive rat arteries display impaired nitric oxide-dependant vasodilatation to insulin-like growth factor and insulin. Journal of Hypertension, 20, S284-S284.
Padmanabhan, S., Padmanabhan, A., Dominiczak, A.F. and Connell, J. (2002) A web-based hypertension genetics resource. Journal of Hypertension, 20, S24-S24.
Stanton, T., Inglis, G.C., Padmanabhan, S. , Dominiczak, A.F. , Jardine, A.G. and Connell, J.M. (2002) Variation at the beta-1 adrenoceptor gene locus affects left ventricular mass in renal failure. Journal of Nephrology, 15(5), pp. 512-518.
Stanton, T., Padmanabhan, S., Payne, J.R., Watt, G., Montgomery, H.E., Jardine, A.G., Dominiczak, A.F. and Connell, J. (2002) The role of beta-1 adrenoceptor variation in determining LV mass in normal, athletic and disease populations. Hypertension, 40(4), p. 576.
2001
Berry, C., Touyz, R. , Dominiczak, A.F., Webb, R.C. and Johns, D.G. (2001) Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. American Journal of Physiology: Heart and Circulatory Physiology, 281(6), H2337-H2365.
Berry, C. , Anderson, N., Kirk, A., Dominiczak, A. and McMurray, J. (2001) Renin angiotensin system inhibition is associated with reduced free radical concentrations in arteries of patients with coronary heart disease. Heart, 86(2), pp. 217-220. (doi: 10.1136/heart.86.2.217)
Berry, C., Brosnan, M., Alexander, M., Hamilton, C., McMurray, J. and Dominiczak, A.F. (2001) Mechanisms of oxidative free radical generation in human arteries. Clinical Science, 101(2), 7P.
Berry, C., Brosnan, M., Fennell, J., Hamilton, C. and Dominiczak, A. (2001) Oxidative stress and vascular damage in hypertension. Current Opinion in Nephrology and Hypertension, 10(2), pp. 247-255.
Cohuet, G., Challande, P., Osborne-Pellegrin, M., Arribas, S., Dominiczak, A. , Louis, H., Laurent, S. and Lacolley, P. (2001) Mechanical strength of the isolated carotid artery in SHR. Hypertension, 38(5), pp. 1167-1171. (doi: 10.1161/hy1101.095995)
De Lange, R.P., Burr, K., Clark, J.S., Negrin, C.D., Brosnan, M.J., St Clair, D.M., Dominiczak, A.F. and Shaw, D.J. (2001) Mapping and sequencing rat dishevelled-1: a candidate gene for cerebral ischaemic insult in a rat model of stroke. Neurogenetics, 3(2), pp. 99-106. (doi: 10.1007/s100480000099)
Dorrance, A., Graham, D., Webb, R., Fraser, R. and Dominiczak, A. (2001) Increased membrane sphingomyelin and arachidonic acid in stroke-prone spontaneously hypertensive rats. American Journal of Hypertension, 14(11), pp. 1149-1153. (doi: 10.1016/S0895-7061(01)02188-4)
Hamilton, C.A., Berg, G.A., Pathi, V. and Dominiczak, A.F. (2001) Resistance of EDHF-mediated relaxations to oxidative stress in human radial arteries. In: Vanhoutte, P.M. (ed.) EDHF 2000. Taylor & Francis: London, pp. 370-375. ISBN 9780415269049
Hamilton, C.A., McPhaden, A.R., Berg, G., Pathi, V. and Dominiczak, A.F. (2001) Is hydrogen peroxide an EDHF in human radial arteries? American Journal of Physiology: Heart and Circulatory Physiology, 280, H2451-H2455.
Hamilton, C., Brosnan, M., McIntyre, M., Graham, D. and Dominiczak, A. (2001) Superoxide excess in hypertension and aging - A common cause of endothelial dysfunction. Hypertension, 37, pp. 529-534. (doi: 10.1161/01.HYP.37.2.529)
James, D.J., Cairns, F., Salt, I.P. , Murphy, G.J., Dominiczak, A.F., Connell, J.M.C. and Gould, G.W. (2001) Skeletal muscle of stroke-prone spontaneously hypertensive rats exhibits reduced insulin-stimulated glucose transport and elevated levels of caveolin and flotillin. Diabetes, 50(9), pp. 2148-2156. (doi: 10.2337/diabetes.50.9.2148)
Jamieson, A., Ingham, D.G., Dominiczak, A.F. and Connell, J.M. (2001) Not the usual cause of superior vena cava obstruction. Scottish Medical Journal, 46(2), pp. 51-52. (doi: 10.1177/003693300104600208)
Knight, J. et al. (2001) No support for linkage of chromosome 17(q21-24) to Essential Hypertension in the MRC British Genetics of Hypertension (MRC BRIGHT) Study. American Journal of Human Genetics, 69(4), p. 559.
MacKay, A., Hamilton, C., McArthur, K., Berg, G., Tropeano, A., Boutouyrie, P., Reid, J. and Dominiczak, A. (2001) Radial artery hypertrophy occurs in coronary atherosclerosis and is independent of blood pressure. Clinical Science, 100(5), pp. 509-516.
MacKenzie, C.J., Wakefield, J.M., Cairns, F., Dominiczak, A.F. and Gould, G.W. (2001) Regulation of glucose transport in aortic smooth muscle cells by cAMP and cGMP. Biochemical Journal, 353, pp. 513-519.
Marks, L., Carswell, H., Peters, E., Graham, D., Patterson, J., Dominiczak, A. and Macrae, I. (2001) Characterization of the microglial response to cerebral ischemia in the stroke-prone spontaneously hypertensive rat. Hypertension, 38, pp. 116-122. (doi: 10.1161/01.HYP.38.1.116)
Negrin, C., McBride, M. , Carswell, H., Graham, D., Carr, F., Clark, J., Jeffs, B., Anderson, N., Macrae, I. and Dominiczak, A. (2001) Reciprocal consomic strains to evaluate Y chromosome effects. Hypertension, 37, pp. 391-397. (doi: 10.1161/01.HYP.37.2.391)
Nicklin, S., Reynolds, P., Brosnan, M., White, S., Curiel, D., Dominiczak, A. and Baker, A. (2001) Analysis of cell-specific promoters for viral gene therapy targeted at the vascular endothelium. Hypertension, 38(1), pp. 65-70. (doi: 10.1161/01.HYP.38.1.65)
Nicklin, S., Von Seggern, D., Work, L., Pek, D., Dominiczak, A., Nemerow, G. and Baker, A. (2001) Ablating adenovirus type 5 fiber-CAR binding and HI loop insertion of the SIGYPLP peptide generate an endothelial cell-selective adenovirus. Molecular Therapy, 4(6), pp. 534-542. (doi: 10.1006/mthe.2001.0489)
Petrie, J. , Collison, M., Connell, J., Gould, G. and Dominiczak, A. (2001) CD36 deficiency and insulin resistance. Lancet, 358(9277), pp. 242-243. (doi: 10.1016/S0140-6736(01)05428-9)
Stanton, T., Jardine, A. G., Dominiczak, A. F. and Connell, J. (2001) Genetic determinants of left ventricular mass: The role of beta-1 adrenoceptor variation. Circulation, 104(17), p. 197.
Zicha, J., Negrin, C., Dobesova, Z., Carr, F., Vokurkova, M., McBride, M., Kunes, J. and Dominiczak, A. (2001) Altered Na+-K+ pump activity and plasma lipids in salt-hypertensive Dahl rats: relationship to Atp1a1 gene. Physiological Genomics, 6(2), pp. 99-104.
2000
Caulfield, M. et al. (2000) A new tool for checks of data precision within the MRC British genetics of hypertension study. Journal of Hypertension, 18, S180-S180.
Collison, M., Campbell, I., Salt, I. , Dominiczak, A., Connell, J., Lyall, H. and Gould, G. (2000) Sex hormones induce insulin resistance in 3T3-L1 adipocytes by reducing cellular content of IRS proteins. Diabetologia, 43(11), pp. 1374-1380. (doi: 10.1007/s001250051541)
Collison, M., Glazier, A., Graham, D., Morton, J., Dominiczak, M., Aitman, T., Connell, J., Gould, G. and Dominiczak, A. F. (2000) Cd36 and molecular mechanisms of insulin resistance in the stroke-prone spontaneously hypertensive rat. Diabetes, 49(12), pp. 2222-2226. (doi: 10.2337/diabetes.49.12.2222)
Devlin, A. M., Clark, J. S., Reid, J. L. and Dominiczak, A. F. (2000) DNA synthesis and apoptosis in smooth muscle cells from a model of genetic hypertension. Hypertension, 36(1), pp. 110-115. (doi: 10.1161/01.HYP.36.1.110)
Graham, D., Collison, M., Glazier, A., Morton, J., Aitman, T., Connell, J., Gouid, G. and Dominiczak, A. F. (2000) Cd36 gene and molecular mechanisms in insulin resistance in the SHRSP. Journal of Hypertension, 18, S173-S173.
Munroe, P. et al. (2000) Analysis of the angiotensinogen gene in the MRC British genetics of Hypertension study. American Journal of Human Genetics, 67(4), p. 304.
1999
Alexander, Y. M., Brosnan, J. M., Hamilton, C. A., Downie, P., Devlin, A. M., Dowell, F., Martin, W., Prentice, H. M., O'Brien, T. and Dominiczak, A. F. (1999) Gene transfer of endothelial nitric oxide synthase improves nitric oxide-dependent endothelial function in a hypertensive rat model. Cardiovascular Research, 43(3), pp. 798-807. (doi: 10.1016/S0008-6363(99)00146-7) (PMID:10690352)
Anderson, N. H., Devlin, A. M., Graham, D. , Morton, J. J., Hamilton, C. A., Reid, J. L., Schork, N. J. and Dominiczak, A. F. (1999) Telemetry for cardiovascular monitoring in a pharmacological study: new approaches to data analysis. Hypertension, 33(1), pp. 248-255. (doi: 10.1161/01.HYP.33.1.248) (PMID:9931112)
Hamilton, C.A., Berg, G., McArthur, K., Faichney, A., Jardine, E., Reid, J.L. and Dominiczak, A. (1999) Mechanisms of vasodilation in human conduit arteries. In: Vanhoutte, P.M. (ed.) EDHF: Second International Meeting. Harwood Academic Publishers, pp. 371-380.
1998
Devlin, A. M., Brosnan, M. J., Graham, D. , Morton, J. J., McPhaden, A. R., McIntyre, M., Hamilton, C. A., Reid, J. L. and Dominiczak, A. F. (1998) Vascular smooth muscle cell polyploidy and cardiomyocyte hypertrophy due to chronic NOS inhibition in vivo. American Journal of Physiology: Heart and Circulatory Physiology, 274(1), H52-H59. (PMID:9458851)
Dominiczak, A. , Jeffs, B. and Connell, J. (1998) New genetic concepts in hypertensive cardiovascular disease. Current Opinion in Cardiology, 13(5), pp. 304-311.
1997
Jeffs, B., Clark, J.S., Anderson, N.H., Gratton, J., Brosnan, M.J., Gauguier, D., Reid, J.L., Macrae, I.M. and Dominiczak, A.F. (1997) Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus. Nature Genetics, 16(4), pp. 364-367. (doi: 10.1038/ng0897-364)
Dominiczak, A. F. , Devlin, A. M., Brosnan, M. J., Anderson, N. H., Graham, D. , Clark, J. S., McPhaden, A., Hamilton, C. A. and Reid, J. L. (1997) Left ventricular hypertrophy and arterial blood pressure in experimental models of hypertension. Advances in Experimental Medicine and Biology, 432, pp. 23-33. (doi: 10.1007/978-1-4615-5385-4_3) (PMID:9433508)
Harden, P., MacLeod, M., Rodger, R., Baxter, G., Connell, J., Dominiczak, A. , Junor, B., Briggs, J. and Moss, J. (1997) Effect of renal-artery stenting on progression of renovascular renal failure. Lancet, 349(9059), pp. 1133-1136. (doi: 10.1016/S0140-6736(96)10093-3)
1996
Arribas, S. M., Gordon, J. F., Daly, C. J. , Dominiczak, A. F. and McGrath, J. C. (1996) Confocal microscopic characterization of a lesion in a cerebral vessel of the stroke-prone spontaneously hypertensive rat. Stroke, 27(6), pp. 1118-1123. (doi: 10.1161/01.STR.27.6.1118)
Dominiczak, A. F. , Devlin, A. M., Lee, W. K. , Anderson, N. H., Bohr, D. F. and Reid, J. L. (1996) Vascular smooth muscle polyploidy and cardiac hypertrophy in genetic hypertension. Hypertension, 27(3), pp. 752-759. (doi: 10.1161/01.HYP.27.3.752) (PMID:8613236)
Dominiczak, A.F. and Connell, J.M.C. (1996) Renovascular disease. In: Tooke, J.E. and Lowe, G.D.O. (eds.) Textbook of Vascular Medicine. Edward Arnold: London, pp. 199-207. ISBN 9780340557914
1995
Arribas, S., Daly, C. , Dominiczak, A. and McGrath, J. (1995) Reduced vasodilator responses to noradrenaline correlates with decreased density of -adrenoceptor flurophore binding in the basilar artery from old WKY rats. Methods and Finding in Experimental and Clinical Pharmacology, 17, CO30.
Arribas, S.M., Gordon, J.F., Daly, C.J. , Davidson, A., Dominiczak, A. and McGrath, J.C. (1995) Structural and functional alterations in the basilar artery from stroke prone spontaneously hypertensive rats. In: 7th European Meeting on Hypertension, Milan, Italy, 9-12 Jun 1995, p. 12.
MacLeod, M., Taylor, A., Baxter, G., Harden, P., Briggs, D., Moss, J., Semple, P., Connell, J. and Dominiczak, A. (1995) Renal artery stenosis managed by Palmaz stent insertion: Technical and clinical outcome. Journal of Hypertension, 13(12), pp. 1791-1795.
MacLeod, M., Connell, J., Harden, P., Briggs, J., Moss, J. and Dominiczak, A. (1995) Transluminal Vascular Stents for Ostial Atherosclerotic Renal-Artery Stenosis. Lancet, 346(8982), pp. 1109-1110.
1994
Arribas, S., Gordon, J.F., Daly, C. , Davidson, A., Dominiczak, A. and McGrath, J.C. (1994) Vascular smooth muscle rearrangement and impaired contractions in basilar artery of the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 12(11), p. 1319.
Dominiczak, A.F. and Bohr, D.F. (1994) Experimental hypertension in the pig. In: Ganten, D. and de Jong, W. (eds.) Experimental and Genetic Models of Hypertension. Series: Handbook of hypertension (16). Elsevier Science: 1994, pp. 560-580. ISBN 9780444897152
1993
Dominiczak, A. and Bohr, D. F. (1993) Vascular smooth muscle contraction and relaxation. In: Izzo, J.L. and Black, H.R. (eds.) Hypertension Primer. American Heart Association: Dallas, Texas, pp. 553-554.
1991
Bohr, D.F., Furspan, P.B. and Dominiczak, A. (1991) Many membrane abnormalities in hypertension result from one primary defect. In: Moreland, W. (ed.) Regulation of Smooth Muscle. Plenum Publishing Corporation, pp. 291-301.
1990
O'Connell, J., Dominiczak, A. , Isles, C., McLellan, A., Davidson, G., Gray, C. and Connell, J. (1990) A Comparison of Calcium Pentagastrin and Trh Tests in Screening for Medullary Carcinoma of the Thyroid in Men-Iia. Clinical Endocrinology, 32(4), pp. 417-423. (doi: 10.1111/j.1365-2265.1990.tb00881.x)
Articles
McCallum, L. et al. (2024) UMOD genotype-dependent effects of Torasemide on ambulatory blood pressure: a multicentre genotype-blinded trial. Hypertension, 81(10), pp. 2049-2059. (doi: 10.1161/HYPERTENSIONAHA.124.23122) (PMID:39077768) (PMCID:PMC11460757)
Zhou, M., Mary, S. , Delles, C. , Padmanabhan, S. , Graham, D. , McBride, M. W. and Dominiczak, A. (2024) Insights into uromodulin and blood pressure. Current Hypertension Reports, (doi: 10.1007/s11906-024-01317-0) (PMID:39259220) (Early Online Publication)
Padmanabhan, S. , Delles, C. and Dominiczak, A. F. (2024) Beyond genome-wide scans: advancing hypertension genomics into the future. Hypertension, 81(6), pp. 1186-1189. (doi: 10.1161/HYPERTENSIONAHA.124.21371) (PMID:38748763)
Tran, T. Q. B. et al. (2024) Assessing machine learning for diagnostic classification of hypertension types identified by ambulatory blood pressure monitoring. CJC Open, 6(6), pp. 798-804. (doi: 10.1016/j.cjco.2024.03.005) (PMID:39022171) (PMCID:PMC11250845)
Keaton, J. M. et al. (2024) Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits. Nature Genetics, 56(5), pp. 778-791. (doi: 10.1038/s41588-024-01714-w) (PMID:38689001) (PMCID:PMC11096100)
Cui, L. et al. (2023) Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing. Genome Biology, 24(1), 215. (doi: 10.1186/s13059-023-03060-2) (PMID:37773188) (PMCID:PMC10540365)
Brown, C. E., Casey, H., Dominiczak, A. F. , Kerr, S., Campbell, A. and Delles, C. (2023) Impact of preeclampsia on cardiovascular events: an analysis of the Generation Scotland: Scottish family health study. Journal of Human Hypertension, 37(8), pp. 735-741. (doi: 10.1038/s41371-023-00812-2) (PMID:36973315)
Arisido, M. W. et al. (2023) Cluster analysis of angiotensin biomarkers to identify antihypertensive drug treatment in population studies. BMC Medical Research Methodology, 23, 131. (doi: 10.1186/s12874-023-01930-8) (PMID:37245005) (PMCID:PMC10224304)
Tran, T. Q. B. et al. (2023) Predictive accuracy and clinical utility of machine learning prediction for classifying blood pressure status. SSRN, (doi: 10.2139/ssrn.4307704)
Padmanabhan, S. , Du Toit, C. and Dominiczak, A. F. (2023) Cardiovascular precision medicine – a pharmacogenomic perspective. Cambridge Prisms: Precision Medicine, 1, pp. 1-54. e28. (doi: 10.1017/pcm.2023.17)
Mary, S. , Boder, P., Padmanabhan, S. , McBride, M. W. , Graham, D. , Delles, C. and Dominiczak, A. F. (2022) The role of uromodulin in salt-sensitive hypertension. Hypertension, 79, pp. 2419-2429. (doi: 10.1161/HYPERTENSIONAHA.122.19888) (PMID:36378920) (PMCID:PMC9553220)
Le, N. N., Tran, T. Q. B., Lip, S. , McCallum, L., McClure, J. , Dominiczak, A. F. , Gill, D. and Padmanabhan, S. (2022) Unravelling the distinct effects of systolic and diastolic blood pressure using Mendelian randomisation. Genes, 13(7), 1226. (doi: 10.3390/genes13071226) (PMID:35886009) (PMCID:PMC9323763)
Chen, J., Chen, X., Dominiczak, A. F. , Carey, R. M., Laffer, C. L., Elijovich, F., Taler, S. J., Dudenbostel, T., Touyz, R. M. and Wang, J.-G. (2022) A rare disease leading to hypertension. Hypertension, 79(6), pp. 1147-1152. (doi: 10.1161/HYPERTENSIONAHA.122.18678) (PMID:35300529)
Lopez, A.-G., Dominiczak, A. F. , Touyz, R. , Schlaich, M., de Freminville, J.-B. and Amar, L. (2022) Hypertension with negative metaiodobenzylguanidine scintigraphy. Hypertension, 79(2), pp. 474-478. (doi: 10.1161/HYPERTENSIONAHA.121.18012) (PMID:34879700)
Dominiczak, A. F. and Meyer, T. J. (2021) Hypertension update: a reflection of the past decade. Hypertension, 78(6), pp. 1670-1673. (doi: 10.1161/HYPERTENSIONAHA.121.18596) (PMID:34757771) (PMCID:PMC8577297)
Boder, P., Mary, S. , Mark, P. B. , Leiper, J. , Dominiczak, A. F. , Padmanabhan, S. , Rampold, L. and Delles, C. (2021) Mechanistic interactions of uromodulin with the thick ascending limb: perspectives in physiology and hypertension. Journal of Hypertension, 39(8), pp. 1490-1504. (doi: 10.1097/HJH.0000000000002861) (PMID:34187999) (PMCID:PMC7611110)
Padmanabhan, S. and Dominiczak, A. F. (2021) Genomics of hypertension: the road to precision medicine. Nature Reviews Cardiology, 18(4), pp. 235-250. (doi: 10.1038/s41569-020-00466-4) (PMID:33219353)
Surendran, P. et al. (2020) Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics, 52(12), pp. 1314-1332. (doi: 10.1038/s41588-020-00713-x) (PMID:33230300) (PMCID:PMC7610439)
Steinthorsdottir, V. et al. (2020) Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women. Nature Communications, 11, 5976. (doi: 10.1038/s41467-020-19733-6) (PMID:33239696) (PMCID:PMC7688949)
Erzurumluoglu, A. M. et al. (2020) Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. Molecular Psychiatry, 25(10), pp. 2392-2409. (doi: 10.1038/s41380-018-0313-0) (PMID:30617275) (PMCID:PMC7515840)
Dominiczak, A. and Mancia, G. (2020) Joint editorial for the International Society of Hypertension guidelines. Hypertension, 75(6), p. 1419. (doi: 10.1161/HYPERTENSIONAHA.120.15224) (PMID:32370573)
Ntalla, I. et al. (2020) Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nature Communications, 11, 2542. (doi: 10.1038/s41467-020-15706-x) (PMID:32439900) (PMCID:PMC7242331)
Teumer, A. et al. (2019) KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern. JCI Insight, 4(23), e131156. (doi: 10.1172/jci.insight.131156) (PMID:31600170) (PMCID:PMC6962032)
Cameron, A. C. et al. (2019) Progressive hypertension and severe left ventricular outflow tract obstruction. Hypertension, 74(6), pp. 1216-1225. (doi: 10.1161/hypertensionaha.119.13343) (PMID:31587571)
Aitken, S. et al. (2019) Finding diagnostically useful patterns in quantitative phenotypic data. American Journal of Human Genetics, 105(5), pp. 933-946. (doi: 10.1016/j.ajhg.2019.09.015) (PMID:31607427)
Dominiczak, A. F. , de Champvallins, M., Brzozowska-Villatte, R. and Asmar, R. (2019) Efficacy of a new single-pill combination of a thiazide-like diuretic and a calcium channel blocker (indapamide sustained release/amlodipine) in essential hypertension. Journal of Hypertension, 37(11), pp. 2280-2289. (doi: 10.1097/HJH.0000000000002177) (PMID:31246894)
Lip, S. , Tan, L. E., Jeemon, P., McCallum, L., Dominiczak, A. F. and Padmanabhan, S. (2019) Diastolic blood pressure J-curve phenomenon in a tertiary-care hypertension clinic. Hypertension, 74(4), pp. 767-775. (doi: 10.1161/HYPERTENSIONAHA.119.12787) (PMID:31422693) (PMCID:PMC6756261)
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Newhouse, S. et al. (2005) Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. Human Molecular Genetics, 14(13), pp. 1805-1814. (doi: 10.1093/hmg/ddi187)
Padmanabhan, S., Munroe, P.B., Brown, M., Clayton, D., Farrall, M., Webster, J., Lathrop, M., Caulfield, M., Dominiczak, A.F. and Connell, J. (2005) Chromosome 2p shows genome wide significant linkage to anti-hypertensive medication response in the British genetics hypertension (BRIGHT) study. Hypertension, 46(4), p. 886.
Strahorn, P., Graham, D., Charchar, F., Sattar, N. , McBride, M. and Dominiczak, A. (2005) Genetic determinants of metabolic syndrome components in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 23(12), pp. 2179-2186.
McBride, M.W. , Charchar, F.J., Graham, D. , Miller, W.H. , Strahorn, P., Carr, F.J. and Dominiczak, A.F. (2004) Functional genomics in rodent models of hypertension. Journal of Physiology, 554(1), pp. 56-63. (doi: 10.1113/jphysiol.2003.049361)
Antier, D., Carswell, H., Brosnan, M., Hamilton, C., Macrae, I., Groves, S., Jardine, E., Reid, J. and Dominiczak, A. (2004) Increased levels of superoxide in brains from old female rats. Free Radical Research, 38(2), pp. 177-183. (doi: 10.1080/10715760310001643294)
Carswell, H.V., Bingham, D., Wallace, K., Nilsen, M., Graham, D.I., Dominiczak, A.F. and Macrae, I.M. (2004) Differential effects of 17beta-estradiol upon stroke damage in stroke prone and normotensive rats. Journal of Cerebral Blood Flow and Metabolism, 24(3), pp. 298-304. (doi: 10.1097/01.WCB.0000112322.75217.FD)
Charchar, F., Padmanabhan, S. , Anderson, N.H., Tomaszewski, M., Upton, M.N., McConnachie, A. , Connell, J.M., Watt, G.C.M., Dominiczak, A.F. and Charchar, F.J. (2004) Y chromsome variant is a predictor of cardiovascular mortality. Journal of Hypertension: Supplement, 22(S1), S58-S59.
Charchar, F.J., Tomaszewski, M., Lacka, B., Zakrzewski, J., Zukowska-Szczechowska, E., Grzeszczak, W. and Dominiczak, A.F. (2004) Association of the human Y chromosome with cholesterol levels in the general population. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(2), pp. 308-312. (doi: 10.1161/01.ATV.0000113291.39267.0a)
Dominiczak, A. , Brain, N., Charchar, F., McBride, M. , Hanlon, N. and Lee, W. (2004) Genetics of hypertension: Lessons learnt from Mendelian and polygenic syndromes. Clinical and Experimental Hypertension, 26(7-8), pp. 611-620. (doi: 10.1081/CEH-200031939)
Graham, D., Hamilton, C., Beattie, E., Spiers, A. and Dominiczak, A. (2004) Comparison of the effects of omapatrilat and irbesartan hydrochlorothiazide on endothelial function and cardiac hypertrophy in the stroke-prone spontaneously hypertensive rat: sex differences. Journal of Hypertension, 22(2), pp. 329-337. (doi: 10.1097/01.hjh.0000098240.58662.93)
Graham, D., Hamilton, C., Beattie, E., Spiers, A. and Dominiczak, A.F. (2004) Comparison of the effects of omapatrilat and irbesartan/hydrochlorothiazide on endothelial function and cardiac hypertrophy in the stroke-prone spontaneously hypertensive rat: sex differences. Journal of Hypertension, 22(2), pp. 329-337.
Hamilton, C., Miller, W., Al Benna, S., Brosnan, M., Drummond, R., McBride, M. and Dominiczak, A. (2004) Strategies to reduce oxidative stress in cardiovascular disease. Clinical Science, 106, pp. 219-234. (doi: 10.1042/CS20030379)
Hunt, E., Hanlon, N., Leader, D.P., Bryce, H. and Dominiczak, A.F. (2004) The visual language of synteny. OMICS: A Journal of Integrative Biology, 8(4), pp. 289-305. (doi: 10.1089/omi.2004.8.289.)
Kuznetsova, T. et al. (2004) Relationship between left ventricular mass and the ACE D/I polymorphism varies according to sodium intake. Journal of Hypertension, 22(2), pp. 287-295.
Newhouse, S. et al. (2004) No association of the WNK1 gene with essential hypertension in the MRC BRIGHT study. Journal of Hypertension, 22, S212-S212.
Padmanabhan, S. , Connell, J.M.C., Dominiczak, A.F. , Inglis, G., Macfarlane, P.W. and Watt, G. (2004) Heritability and genetic determinants of electrocardiographic measures of left ventricular mass - a two generation family study. Journal of Hypertension: Supplement, 22(S1), S180-S181.
Tomaszewski, M., Charchar, F., Crawford, L., Zukowska-Sczechowska, E., Grzeszczak, W., Sattar, N. and Dominiczak, A. (2004) Serum C-reactive protein and lipids in ultra-marathon runners. American Journal of Cardiology, 94(1), pp. 125-126. (doi: 10.1016/j.amjcard.2004.03.043)
Tomaszewski, M., Charchar, F., Lacka, B., Pesonen, U., Wang, W., Zukowska-Szczechowska, E., Grzeszczak, W. and Dominiczak, A. (2004) Epistatic interaction between beta2-adrenergic receptor and neuropeptide Y genes influences LDL-cholesterol in hypertension. Hypertension, 44(5), pp. 689-694. (doi: 10.1161/01.HYP.0000143844.81979.61)
Stanton, T., Payne, J.R., Montgomery, H.E., Watt, G., Dominiczak, A.F. , Jardine, A.G. and Connell, J.M. (2003) Genetic determinants of left ventricular mass: the role of beta-1 adrenoceptor variation in normal, athletic, and disease populations. Journal of the American College of Cardiology, 41(6 (S1)), p. 273. (doi: 10.1016/S0735-1097(03)82282-9)
Brown, M., Cruickshank, J., Dominiczak, A. , MacGregor, G., Poulter, N., Russell, G., Thom, S. and Williams, B. (2003) Better blood pressure control: how to combine drugs. Journal of Human Hypertension, 17, pp. 81-86. (doi: 10.1038/sj.jhh.1001511)
Caulfield, M. et al. (2003) Genome-wide mapping of human loci for essential hypertension. Lancet, 361(9375), pp. 2118-2123. (doi: 10.1016/S0140-6736(03)13722-1)
Charchar, F., Tomaszewski, M., Strahorn, P., Champagne, B. and Dominiczak, A. (2003) Y is there a risk to being male? Trends in Endocrinology and Metabolism, 14, pp. 163-168. (doi: 10.1016/S1043-2760(02)00032-8)
Dominiczak, A.F. and McBride, M.W. (2003) Genetics of common polygenic stroke. Nature Genetics, 35(2), pp. 116-117.
Izzard, A.S., Graham, D., Burnham, M.P., Heerkens, E.H., Dominiczak, A.F. and Heagerty, A.M. (2003) Myogenic and structural properties of cerebral arteries from the stroke-prone spontaneously hypertensive rat. American Journal of Physiology: Heart and Circulatory Physiology, 285, H1489-H1494. (doi: 10.1152/ajpheart.00352.2003)
Khan, I.Y., Taylor, P.D., Dekou, V., Seed, P.T., Lakasing, L., Graham, D., Dominiczak, A.F. , Hanson, M.A. and Poston, L. (2003) Gender-linked hypertension in offspring of lard-fed pregnant rats. Hypertension, 41(1), pp. 168-175.
Khan, L., Taylor, P., Dekou, V., Seed, P., Lakasing, L., Graham, D., Dominiczak, A. , Hanson, M. and Poston, L. (2003) Gender-linked hypertension in offspring of lard-fed pregnant rat. Hypertension, 41, pp. 168-175. (doi: 10.1161/01.HYP.0000047511.97879.FC)
McBride, M. , Carr, F., Graham, D., Anderson, N., Clark, J., Lee, W., Charchar, F., Brosnan, M. and Dominiczak, A. (2003) Microarray analysis of rat chromosome 2 congenic strains. Hypertension, 41, pp. 847-853. (doi: 10.1161/01.HYP.0000047103.07205.03)
Pell, J., Smith, G., Dominiczak, A., Cobbe, S., Dobbie, R., McMahon, A. and Ford, I. (2003) Family history of premature death from ischaemic heart disease is associated with an increased risk of delivering a low birth weight baby. Heart, 89(10), pp. 1249-1250. (doi: 10.1136/heart.89.10.1249)
Stanton, T., Robb, S., Payne, J., Montgomery, H., Watt, G., McDonagh, T., Dominiczak, A. , Connell, J. and Dargie, H. (2003) The effect of beta-1 adrenoceptor genetic variation on left ventricular mass. Circulation, 108(17), p. 180.
Tomaszewski, M., Charchar, F.J., Padmanabhan, S. , Zukowska-Szczechowska, E., Grzeszczak, W. and Dominiczak, A.F. (2003) Cardiovascular diseases and G-protein beta 3 subunit gene (GNB3) in the era of genomewide scans. Journal of Human Hypertension, 17(6), pp. 379-380. (doi: 10.1038/sj.jhh.1001559)
Tomaszewski, M. et al. (2003) Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity - How low can you go? Arteriosclerosis, Thrombosis, and Vascular Biology, 23(9), pp. 1640-1644. (doi: 10.1161/01.ATV.0000087036.75849.0B)
Tomaszewski, M. et al. (2002) Essential hypertension and beta(2)-adrenergic receptor gene linkage and association analysis. Hypertension, 40(3), pp. 286-291. (doi: 10.1161/01.HYP.0000029105.21202.FE)
Duncan, A. C., Petrie, J. R. , Brosnan, M. J., Devlin, A. M., Bass, R. A., Charnock-Jones, D. S., Connell, J. M., Dominiczak, A. F. and Lumsden, M. A. (2002) Is estradiol cardioprotection a nitric oxide-mediated effect? Human Reproduction, 17(7), pp. 1918-1924. (doi: 10.1093/humrep/17.7.1918)
Brosnan, M., Hamilton, C., Graham, D., Lygate, C., Jardine, E. and Dominiczak, A. (2002) Irbesartan lowers superoxide levels and increases nitric oxide bioavailability in blood vessels from spontaneously hypertensive stroke-prone rats. Journal of Hypertension, 20(2), pp. 281-286.
Carr, F.J., Negrin, C.D., Clark, J.S., Graham, D., McBride, M.W. , Anderson, N.W. and Dominiczak, A.F. (2002) Chromosome 2 reciprocal congenic strains to evaluate the effect of the genetic background on blood pressure. Scottish Medical Journal, 47(1), pp. 7-9. (doi: 10.1177/003693300204700104)
Carr, F., McBride, M. , Carswell, H., Graham, D., Strahorn, P., Clark, J., Charchar, F. and Dominiczak, A. (2002) Genetic aspects of stroke: Human and experimental studies. Journal of Cerebral Blood Flow and Metabolism, 22(7), pp. 767-773. (doi: 10.1097/00004647-200207000-00001)
Caulfield, M. et al. (2002) The MRC British Genetics of Hypertension Study - Genome-wide screen results. Journal of Hypertension, 20, S7-S7.
Charchar, F.J. et al. (2002) The Y chromosome effect on blood pressure in two European populations. Hypertension, 39(2), pp. 353-356. (doi: 10.1161/hy0202.103413)
Fennell, J., Brosnan, M., Frater, A., Hamilton, C., Alexander, M., Nicklin, S., Heistad, D., Baker, A. and Dominiczak, A. (2002) Adenovirus-mediated overexpression of extracellular superoxide dismutase improves endothelial dysfunction in a rat model of hypertension. Gene Therapy, 9(2), pp. 110-117. (doi: 10.1038/sj.gt.3301633)
Hamilton, C., O'Dowd, G., McIntosh, L., Berg, G., Butler, J., Pathi, V., Williams, R., Reid, J. and Dominiczak, A. (2002) Vasorelaxant properties of isolated human radial arteries: comparison with internal mammary arteries. Atherosclerosis, 160(2), pp. 345-353. (doi: 10.1016/S0021-9150(01)00605-0)
Hamilton, C., Brosnan, M., Al Benna, S., Berg, G. and Dominiczak, A. (2002) NAD(P)H oxidase inhibition improves endothelial function in rat and human blood vessels. Hypertension, 40(5), pp. 755-762. (doi: 10.1161/01.HYP.0000037063.90643.0B)
McBride, M. , Carswell, H., Graham, D., Carr, F., Charchar, F., Macrae, I. and Dominiczak, A. (2002) Genetic and gender determinants of cerebrovascular disease. Seminars in Nephrology, 22, pp. 127-134. (doi: 10.1053/snep.2002.30213)
McCallum, R., Petrie, J. , Dominiczak, A. and Connell, J. (2002) Growth hormone deficiency and vascular risk. Clinical Endocrinology, 57(1), pp. 11-24. (doi: 10.1046/j.1365-2265.2002.01559.x)
McCallum, R.W., Hamilton, C., Graham, D., Jardine, E., Dominiczak, A.F. and Connell, J. (2002) Hypertensive but not normotensive rat arteries display impaired nitric oxide-dependant vasodilatation to insulin-like growth factor and insulin. Journal of Hypertension, 20, S284-S284.
Padmanabhan, S., Padmanabhan, A., Dominiczak, A.F. and Connell, J. (2002) A web-based hypertension genetics resource. Journal of Hypertension, 20, S24-S24.
Stanton, T., Inglis, G.C., Padmanabhan, S. , Dominiczak, A.F. , Jardine, A.G. and Connell, J.M. (2002) Variation at the beta-1 adrenoceptor gene locus affects left ventricular mass in renal failure. Journal of Nephrology, 15(5), pp. 512-518.
Stanton, T., Padmanabhan, S., Payne, J.R., Watt, G., Montgomery, H.E., Jardine, A.G., Dominiczak, A.F. and Connell, J. (2002) The role of beta-1 adrenoceptor variation in determining LV mass in normal, athletic and disease populations. Hypertension, 40(4), p. 576.
Berry, C., Touyz, R. , Dominiczak, A.F., Webb, R.C. and Johns, D.G. (2001) Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide. American Journal of Physiology: Heart and Circulatory Physiology, 281(6), H2337-H2365.
Berry, C. , Anderson, N., Kirk, A., Dominiczak, A. and McMurray, J. (2001) Renin angiotensin system inhibition is associated with reduced free radical concentrations in arteries of patients with coronary heart disease. Heart, 86(2), pp. 217-220. (doi: 10.1136/heart.86.2.217)
Berry, C., Brosnan, M., Alexander, M., Hamilton, C., McMurray, J. and Dominiczak, A.F. (2001) Mechanisms of oxidative free radical generation in human arteries. Clinical Science, 101(2), 7P.
Berry, C., Brosnan, M., Fennell, J., Hamilton, C. and Dominiczak, A. (2001) Oxidative stress and vascular damage in hypertension. Current Opinion in Nephrology and Hypertension, 10(2), pp. 247-255.
Cohuet, G., Challande, P., Osborne-Pellegrin, M., Arribas, S., Dominiczak, A. , Louis, H., Laurent, S. and Lacolley, P. (2001) Mechanical strength of the isolated carotid artery in SHR. Hypertension, 38(5), pp. 1167-1171. (doi: 10.1161/hy1101.095995)
De Lange, R.P., Burr, K., Clark, J.S., Negrin, C.D., Brosnan, M.J., St Clair, D.M., Dominiczak, A.F. and Shaw, D.J. (2001) Mapping and sequencing rat dishevelled-1: a candidate gene for cerebral ischaemic insult in a rat model of stroke. Neurogenetics, 3(2), pp. 99-106. (doi: 10.1007/s100480000099)
Dorrance, A., Graham, D., Webb, R., Fraser, R. and Dominiczak, A. (2001) Increased membrane sphingomyelin and arachidonic acid in stroke-prone spontaneously hypertensive rats. American Journal of Hypertension, 14(11), pp. 1149-1153. (doi: 10.1016/S0895-7061(01)02188-4)
Hamilton, C.A., McPhaden, A.R., Berg, G., Pathi, V. and Dominiczak, A.F. (2001) Is hydrogen peroxide an EDHF in human radial arteries? American Journal of Physiology: Heart and Circulatory Physiology, 280, H2451-H2455.
Hamilton, C., Brosnan, M., McIntyre, M., Graham, D. and Dominiczak, A. (2001) Superoxide excess in hypertension and aging - A common cause of endothelial dysfunction. Hypertension, 37, pp. 529-534. (doi: 10.1161/01.HYP.37.2.529)
James, D.J., Cairns, F., Salt, I.P. , Murphy, G.J., Dominiczak, A.F., Connell, J.M.C. and Gould, G.W. (2001) Skeletal muscle of stroke-prone spontaneously hypertensive rats exhibits reduced insulin-stimulated glucose transport and elevated levels of caveolin and flotillin. Diabetes, 50(9), pp. 2148-2156. (doi: 10.2337/diabetes.50.9.2148)
Jamieson, A., Ingham, D.G., Dominiczak, A.F. and Connell, J.M. (2001) Not the usual cause of superior vena cava obstruction. Scottish Medical Journal, 46(2), pp. 51-52. (doi: 10.1177/003693300104600208)
Knight, J. et al. (2001) No support for linkage of chromosome 17(q21-24) to Essential Hypertension in the MRC British Genetics of Hypertension (MRC BRIGHT) Study. American Journal of Human Genetics, 69(4), p. 559.
MacKay, A., Hamilton, C., McArthur, K., Berg, G., Tropeano, A., Boutouyrie, P., Reid, J. and Dominiczak, A. (2001) Radial artery hypertrophy occurs in coronary atherosclerosis and is independent of blood pressure. Clinical Science, 100(5), pp. 509-516.
MacKenzie, C.J., Wakefield, J.M., Cairns, F., Dominiczak, A.F. and Gould, G.W. (2001) Regulation of glucose transport in aortic smooth muscle cells by cAMP and cGMP. Biochemical Journal, 353, pp. 513-519.
Marks, L., Carswell, H., Peters, E., Graham, D., Patterson, J., Dominiczak, A. and Macrae, I. (2001) Characterization of the microglial response to cerebral ischemia in the stroke-prone spontaneously hypertensive rat. Hypertension, 38, pp. 116-122. (doi: 10.1161/01.HYP.38.1.116)
Negrin, C., McBride, M. , Carswell, H., Graham, D., Carr, F., Clark, J., Jeffs, B., Anderson, N., Macrae, I. and Dominiczak, A. (2001) Reciprocal consomic strains to evaluate Y chromosome effects. Hypertension, 37, pp. 391-397. (doi: 10.1161/01.HYP.37.2.391)
Nicklin, S., Reynolds, P., Brosnan, M., White, S., Curiel, D., Dominiczak, A. and Baker, A. (2001) Analysis of cell-specific promoters for viral gene therapy targeted at the vascular endothelium. Hypertension, 38(1), pp. 65-70. (doi: 10.1161/01.HYP.38.1.65)
Nicklin, S., Von Seggern, D., Work, L., Pek, D., Dominiczak, A., Nemerow, G. and Baker, A. (2001) Ablating adenovirus type 5 fiber-CAR binding and HI loop insertion of the SIGYPLP peptide generate an endothelial cell-selective adenovirus. Molecular Therapy, 4(6), pp. 534-542. (doi: 10.1006/mthe.2001.0489)
Petrie, J. , Collison, M., Connell, J., Gould, G. and Dominiczak, A. (2001) CD36 deficiency and insulin resistance. Lancet, 358(9277), pp. 242-243. (doi: 10.1016/S0140-6736(01)05428-9)
Stanton, T., Jardine, A. G., Dominiczak, A. F. and Connell, J. (2001) Genetic determinants of left ventricular mass: The role of beta-1 adrenoceptor variation. Circulation, 104(17), p. 197.
Zicha, J., Negrin, C., Dobesova, Z., Carr, F., Vokurkova, M., McBride, M., Kunes, J. and Dominiczak, A. (2001) Altered Na+-K+ pump activity and plasma lipids in salt-hypertensive Dahl rats: relationship to Atp1a1 gene. Physiological Genomics, 6(2), pp. 99-104.
Caulfield, M. et al. (2000) A new tool for checks of data precision within the MRC British genetics of hypertension study. Journal of Hypertension, 18, S180-S180.
Collison, M., Campbell, I., Salt, I. , Dominiczak, A., Connell, J., Lyall, H. and Gould, G. (2000) Sex hormones induce insulin resistance in 3T3-L1 adipocytes by reducing cellular content of IRS proteins. Diabetologia, 43(11), pp. 1374-1380. (doi: 10.1007/s001250051541)
Collison, M., Glazier, A., Graham, D., Morton, J., Dominiczak, M., Aitman, T., Connell, J., Gould, G. and Dominiczak, A. F. (2000) Cd36 and molecular mechanisms of insulin resistance in the stroke-prone spontaneously hypertensive rat. Diabetes, 49(12), pp. 2222-2226. (doi: 10.2337/diabetes.49.12.2222)
Devlin, A. M., Clark, J. S., Reid, J. L. and Dominiczak, A. F. (2000) DNA synthesis and apoptosis in smooth muscle cells from a model of genetic hypertension. Hypertension, 36(1), pp. 110-115. (doi: 10.1161/01.HYP.36.1.110)
Graham, D., Collison, M., Glazier, A., Morton, J., Aitman, T., Connell, J., Gouid, G. and Dominiczak, A. F. (2000) Cd36 gene and molecular mechanisms in insulin resistance in the SHRSP. Journal of Hypertension, 18, S173-S173.
Munroe, P. et al. (2000) Analysis of the angiotensinogen gene in the MRC British genetics of Hypertension study. American Journal of Human Genetics, 67(4), p. 304.
Alexander, Y. M., Brosnan, J. M., Hamilton, C. A., Downie, P., Devlin, A. M., Dowell, F., Martin, W., Prentice, H. M., O'Brien, T. and Dominiczak, A. F. (1999) Gene transfer of endothelial nitric oxide synthase improves nitric oxide-dependent endothelial function in a hypertensive rat model. Cardiovascular Research, 43(3), pp. 798-807. (doi: 10.1016/S0008-6363(99)00146-7) (PMID:10690352)
Anderson, N. H., Devlin, A. M., Graham, D. , Morton, J. J., Hamilton, C. A., Reid, J. L., Schork, N. J. and Dominiczak, A. F. (1999) Telemetry for cardiovascular monitoring in a pharmacological study: new approaches to data analysis. Hypertension, 33(1), pp. 248-255. (doi: 10.1161/01.HYP.33.1.248) (PMID:9931112)
Devlin, A. M., Brosnan, M. J., Graham, D. , Morton, J. J., McPhaden, A. R., McIntyre, M., Hamilton, C. A., Reid, J. L. and Dominiczak, A. F. (1998) Vascular smooth muscle cell polyploidy and cardiomyocyte hypertrophy due to chronic NOS inhibition in vivo. American Journal of Physiology: Heart and Circulatory Physiology, 274(1), H52-H59. (PMID:9458851)
Dominiczak, A. , Jeffs, B. and Connell, J. (1998) New genetic concepts in hypertensive cardiovascular disease. Current Opinion in Cardiology, 13(5), pp. 304-311.
Jeffs, B., Clark, J.S., Anderson, N.H., Gratton, J., Brosnan, M.J., Gauguier, D., Reid, J.L., Macrae, I.M. and Dominiczak, A.F. (1997) Sensitivity to cerebral ischaemic insult in a rat model of stroke is determined by a single genetic locus. Nature Genetics, 16(4), pp. 364-367. (doi: 10.1038/ng0897-364)
Dominiczak, A. F. , Devlin, A. M., Brosnan, M. J., Anderson, N. H., Graham, D. , Clark, J. S., McPhaden, A., Hamilton, C. A. and Reid, J. L. (1997) Left ventricular hypertrophy and arterial blood pressure in experimental models of hypertension. Advances in Experimental Medicine and Biology, 432, pp. 23-33. (doi: 10.1007/978-1-4615-5385-4_3) (PMID:9433508)
Harden, P., MacLeod, M., Rodger, R., Baxter, G., Connell, J., Dominiczak, A. , Junor, B., Briggs, J. and Moss, J. (1997) Effect of renal-artery stenting on progression of renovascular renal failure. Lancet, 349(9059), pp. 1133-1136. (doi: 10.1016/S0140-6736(96)10093-3)
Arribas, S. M., Gordon, J. F., Daly, C. J. , Dominiczak, A. F. and McGrath, J. C. (1996) Confocal microscopic characterization of a lesion in a cerebral vessel of the stroke-prone spontaneously hypertensive rat. Stroke, 27(6), pp. 1118-1123. (doi: 10.1161/01.STR.27.6.1118)
Dominiczak, A. F. , Devlin, A. M., Lee, W. K. , Anderson, N. H., Bohr, D. F. and Reid, J. L. (1996) Vascular smooth muscle polyploidy and cardiac hypertrophy in genetic hypertension. Hypertension, 27(3), pp. 752-759. (doi: 10.1161/01.HYP.27.3.752) (PMID:8613236)
Arribas, S., Daly, C. , Dominiczak, A. and McGrath, J. (1995) Reduced vasodilator responses to noradrenaline correlates with decreased density of -adrenoceptor flurophore binding in the basilar artery from old WKY rats. Methods and Finding in Experimental and Clinical Pharmacology, 17, CO30.
MacLeod, M., Taylor, A., Baxter, G., Harden, P., Briggs, D., Moss, J., Semple, P., Connell, J. and Dominiczak, A. (1995) Renal artery stenosis managed by Palmaz stent insertion: Technical and clinical outcome. Journal of Hypertension, 13(12), pp. 1791-1795.
MacLeod, M., Connell, J., Harden, P., Briggs, J., Moss, J. and Dominiczak, A. (1995) Transluminal Vascular Stents for Ostial Atherosclerotic Renal-Artery Stenosis. Lancet, 346(8982), pp. 1109-1110.
Arribas, S., Gordon, J.F., Daly, C. , Davidson, A., Dominiczak, A. and McGrath, J.C. (1994) Vascular smooth muscle rearrangement and impaired contractions in basilar artery of the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 12(11), p. 1319.
O'Connell, J., Dominiczak, A. , Isles, C., McLellan, A., Davidson, G., Gray, C. and Connell, J. (1990) A Comparison of Calcium Pentagastrin and Trh Tests in Screening for Medullary Carcinoma of the Thyroid in Men-Iia. Clinical Endocrinology, 32(4), pp. 417-423. (doi: 10.1111/j.1365-2265.1990.tb00881.x)
Book Sections
Cameron, A.C., Dominiczak, A.F. and Touyz, R.M. (2019) Hypertension. In: Touyz, R.M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer Nature Switzerland: Cham, Switzerland, pp. 331-341. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_31)
Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2019) Genetics of hypertension and heart failure. In: Dorobantu, M., Mancia, G., Grassi, G. and Voicu, V. (eds.) Hypertension and Heart Failure. Series: Updates in hypertension and cardiovascular protection. Springer International Publishing, pp. 15-29. ISBN 9783319933191
Padmanabhan, S. , Aman, A. and Dominiczak, A. F. (2019) Genomics of hypertension. In: Touyz, R.M. and Delles, C. (eds.) Textbook of Vascular Medicine. Springer, pp. 171-181. ISBN 9783030164805 (doi: 10.1007/978-3-030-16481-2_16)
Padmanabhan, S. , Tan, L.-E. and Dominiczak, A. F. (2018) Genetics of blood pressure and hypertension. In: Berbari, A.E. and Mancia, G. (eds.) Disorders of Blood Pressure Regulation. Series: Updates in hypertension and cardiovascular protection. Springer, pp. 135-154. ISBN 9783319599175 (doi: 10.1007/978-3-319-59918-2_10)
Padmanabhan, S. , Caulfield, M. and Dominiczak, A. F. (2014) Genetic basis of blood pressure and hypertension. In: Mancia, Giuseppe, Grassi, Guido and Redon, Josep (eds.) Manual of Hypertension of the European Society of Hypertension, Second Edition. CRC Press: Boca Raton, FL, pp. 115-128. ISBN 9781841849973 (doi: 10.1201/b17072-13)
Delles, C. and Dominiczak, A. F. (2013) Metabolic alterations. In: Mancia, G. (ed.) Resistant Hypertension : Epidemiology, Pathophysiology, Diagnosis and Treatment. Springer, pp. 23-37. ISBN 9788847054158 (doi: 10.1007/978-88-470-5415-8_3)
Padmanabhan, S. and Dominiczak, A. F. (2012) Genetics and hypertension: which information for clinical practice. In: Berbari, Adel E. and Mancia, Giuseppe (eds.) Special Issues in Hypertension. Springer Milan: Milan, pp. 439-452. ISBN 9788847026001 (doi: 10.1007/978-88-470-2601-8_33)
Delles, C. and Dominiczak, A. F. (2010) Redox-related genetic markers of cardiovascular diseases. In: Sauer, H., Shah, A.M. and Laurindo, F.R.M. (eds.) Studies on Cardiovascular Disorders. Series: Oxidative stress in applied basic research and clinical practice. Humana Press, pp. 187-209. ISBN 9781607615996 (doi: 10.1007/978-1-60761-600-9_10)
Tomaszewski, M., Padmanabhan, S. , Miller, W.H., Lee, W.K. and Dominiczak, A.F. (2009) Genetic factors. In: Mancia, G., Grassi, G. and Kjeldsen, S. (eds.) Manual of Hypertension of the European Society of Hypertension. Informa Healthcare: London, pp. 84-93. ISBN 9781841846484
Work, L.M. , Dominiczak, A.F. and McBride, M.W. (2009) The genetic basis of stroke: animal models. In: 3rd Report on Stroke: Genetic research in prevention and in cure. Il Pensiero Scientifico Editore, pp. 219-40.
Brosnan, M.J. and Dominiczak, A.F. (2006) Common diseases, Genetics. In: Ganten, D. and Ruckpaul, K. (eds.) Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine [vol. 1(3)]. Springer. ISBN 9783540442448
Tomaszewski, M., Brain, N. J. R., Charchar, F. J. and Dominiczak, A. F. (2006) Genetics of human essential hypertension - from single mutations to quantitative trait loci. In: Re, R.N., Di Pette, D.J., Schiffrin, E. and Sowers, J.R. (eds.) Molecular Mechanisms of Hypertension. Taylor & Frances Medical, pp. 241-248. ISBN 9781842143049
Carswell, H., McBride, M., Graham, D., Dominiczak, A. and Macrae, I. (2005) Mutant animal models of stroke and gene expression: the stroke-prone spontaneously hypertensive rat. In: Read, SJ and Virley, D (eds.) Stroke Genomics. Series: Methods in Molecular Medicine (104). Humana Press, pp. 49-74. ISBN 978-1-58829-333-6 (doi: 10.1385/1-59259-836-6:049)
Graham, D., McBride, M., Brain, N. and Dominiczak, A. (2005) Congenic/consomic models of hypertension. In: Fennell, J.P. and Baker, A.H. (eds.) Hypertension. Series: Methods in Molecular Medicine (108). Humana Press, pp. 3-15. ISBN 978-1-58829-323-7 (doi: 10.1385/1-59259-850-1:003)
Miller, W.H. , Nicklin, S.A. , Baker, A.H. and Dominiczak, A. (2005) Gene transfer and cardiovascular system. In: Raizada, M.K., Paton, J.F.R., Kasparov, S. and Katovich, M.J. (eds.) Cardiovascular Genomics. Series: Contemporary cardiology. Humana Press: Totowa, NJ, USA, pp. 175-196. ISBN 9781588294005
Anderson, N.H. and Dominiczak, A.F. (2002) Genetic analysis of complex traits. In: Rimoin, D.l., Connor, J.M. and Pyeritz, R.E. (eds.) Emery and Rimoin's Principles and Practice of Medical Genetics [4th ed.]. Harcourt Brace, pp. 410-424. ISBN 9780443064340
Fennell, J.P., Brosnan, M.J., Frater, A.J. and Dominiczak, A.F. (2002) Gene therapy for hypertension : future or fiction? In: Doevendans, P.A. and Kaab, S. (eds.) Cardiovascular Genomics : New Pathophysiological Concepts. Series: Developments in cardiovascular medicine (242). Springer, pp. 65-75. ISBN 9781461353478 (doi: 10.1007/978-1-4615-1005-5_7)
Hamilton, C.A., Berg, G.A., Pathi, V. and Dominiczak, A.F. (2001) Resistance of EDHF-mediated relaxations to oxidative stress in human radial arteries. In: Vanhoutte, P.M. (ed.) EDHF 2000. Taylor & Francis: London, pp. 370-375. ISBN 9780415269049
Hamilton, C.A., Berg, G., McArthur, K., Faichney, A., Jardine, E., Reid, J.L. and Dominiczak, A. (1999) Mechanisms of vasodilation in human conduit arteries. In: Vanhoutte, P.M. (ed.) EDHF: Second International Meeting. Harwood Academic Publishers, pp. 371-380.
Dominiczak, A.F. and Connell, J.M.C. (1996) Renovascular disease. In: Tooke, J.E. and Lowe, G.D.O. (eds.) Textbook of Vascular Medicine. Edward Arnold: London, pp. 199-207. ISBN 9780340557914
Dominiczak, A.F. and Bohr, D.F. (1994) Experimental hypertension in the pig. In: Ganten, D. and de Jong, W. (eds.) Experimental and Genetic Models of Hypertension. Series: Handbook of hypertension (16). Elsevier Science: 1994, pp. 560-580. ISBN 9780444897152
Dominiczak, A. and Bohr, D. F. (1993) Vascular smooth muscle contraction and relaxation. In: Izzo, J.L. and Black, H.R. (eds.) Hypertension Primer. American Heart Association: Dallas, Texas, pp. 553-554.
Bohr, D.F., Furspan, P.B. and Dominiczak, A. (1991) Many membrane abnormalities in hypertension result from one primary defect. In: Moreland, W. (ed.) Regulation of Smooth Muscle. Plenum Publishing Corporation, pp. 291-301.
Conference Proceedings
Sinnott, R.O. et al. (2004) Grid services supporting the usage of secure federated, distributed biomedical data. In: Proceedings of UK e-Science All Hands Meeting, Nottingham, UK, 31 Aug - 3 Sept 2004,
Arribas, S.M., Gordon, J.F., Daly, C.J. , Davidson, A., Dominiczak, A. and McGrath, J.C. (1995) Structural and functional alterations in the basilar artery from stroke prone spontaneously hypertensive rats. In: 7th European Meeting on Hypertension, Milan, Italy, 9-12 Jun 1995, p. 12.
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Ensuring the Science Legacy of COVID-19 in Scotland
Scottish Government
2021 - 2022
- Living Lab: Driving Economic Growth in Glasgow through Real-World Implementation of Precision Medicine
UK Research and Innovation
2020 - 2025
- Confidence in Concept 2020
Medical Research Council
2020 - 2022
- The Lighthouse Laboratory
Department of Health and Social Security
2020 - 2020
- Institutional Translation Partnership Award
Wellcome Trust
2020 - 2022
- Institutional Strategic Support Fund
Wellcome Trust
2019 - 2021
- Stratified Medicine Scotland Innovation Centre (phase 2)
Scottish Funding Council
2019 - 2024
- Stratified Medicine Scotland Innovation Centre (phase 2)
Scottish Enterprise
2019 - 2024
- SMS-IC maintenance contract
Scottish Funding Council
2019 - 2020
- Confidence in Concept 2019
Medical Research Council
2019 - 2021
- Graph-Based Data Federation for Healthcare Data Science
Health Data Research UK
2019 - 2019
- Stratified Medicine Scotland Innovation Centre
Scottish Funding Council
2019 - 2019
- Leaders Skills Development
Scottish Funding Council (SFC)
2018 - 2021
- Wolfson Merit Award
The Royal Society
2018 - 2023
- Glasgow Precision Diagnostics and Therapeutics - Confidence in Concept
Medical Research Council
2018 - 2020
- Pools Engagement in European Research (PEER) and Postgraduate and Early Career Research Exchanges (PECRE)
Scottish Funding Council
2018 - 2019
- Accelerating Precision Diagnostics - Bridging the Gap
Medical Research Council
2017 - 2019
- AZ Collaboration
Scottish Enterprise
2017 - 2018
- Institutional Strategic Support Fund (2016)
Wellcome Trust
2016 - 2021
- Continued Development of the Scottish Universities Life Sciences Alliance: SULSA
Scottish Funding Council
2016 - 2021
- Stage differentiation in malaria parasites
The Royal Society
2016 - 2021
- Priming Innovative Translational Research - the Glasgow Chemical Biology Programme
Medical Research Council
2016 - 2018
- The Precision Medicine Ecosystem
Chief Scientist Office
2016 - 2017
- Glasgow Molecular Pathology (GMP) Node
Medical Research Council
2015 - 2019
- Glasgow Clinical Research Facility: Translating Research into Benefits for Patients
Wellcome Trust
2015 - 2015
- Impact Acceleration Account Award (IAA)
Biotechnology and Biological Sciences Research Council
2015 - 2017
- Construction of an Imaging Center of Excellence (ICE) at the New south Glasgow University hospital
Medical Research Council
2015 - 2016
- ISSF Year 4 - Pilot Projects
Wellcome Trust
2014 - 2017
- Investigation of Osteopontin as a candidate gene for left ventricular hypertrophy
British Heart Foundation
2014 - 2018
- BHF centre of excellence
British Heart Foundation
2014 - 2019
- Priming Innovative Translational Research - The University of Glasgow Confidence in Concept Programme
Medical Research Council
2014 - 2015
- Stratified Medicine and Imaging
European Regional Development Fund
2014 - 2015
- Genetic, molecular and functional dissection of a novel pathway for hypertension: Uromodulin, renal function, sodium homeostasis and blood pressure.
British Heart Foundation
2013 - 2017
- Wolfson Research Merit Award
The Royal Society
2013 - 2018
- The Stratified Medicine Scotland Innovation Centre
Scottish Funding Council
2013 - 2018
- Institutional Strategic Support Fund (ISSF)
Wellcome Trust
2012 - 2018
- Cardiovascular consequences of preeclampsia in women from the Generation Scotland: Scottish Family Health Study.
Chief Scientist Office
2012 - 2015
- The mitochondrial-targeted antioxidant, MitoQ10: a novel therapeutic agent for cardiovascular disease.
British Heart Foundation
2012 - 2012
- EU-MASCARA - Biomarkers for Cardiovascular Disease
European Commission
2011 - 2015
- InterPregGen
European Commission
2011 - 2016
- SAHSC Industry Support Programme
East Scotland European Partnership
2011 - 2014
- Integrated Health - Polyomics and Systems Biomedicine (ISSF Bid)
Wellcome Trust
2011 - 2014
- Glasgow Cancer Research UK Centre (CORE)
Cancer Research UK
2010 - 2015
- MRes Pathology Students
Cancer Research UK
2010 - 2015
- Value in people awards 2010 - 2011
Wellcome Trust
2010 - 2011
- Euratrans
European Commission
2010 - 2014
- Generation Scotland
Chief Scientist Office
2010 - 2011
- Dissecting the mechanism of action of the novel renin angiotensin hormone angiotensin1-9
Medical Research Council
2010 - 2013
- Interrogation and manipulation of miRNA in acute vascular injury
British Heart Foundation
2010 - 2014
- InGenious HyperCare - Integrating Genomics, Clinical Research and Care in Hypertension
European Commission
2009 - 2010
- Wellcome VIP award
Wellcome Trust
2009 - 2009
- BHF Chair
British Heart Foundation
2009 - 2014
- Researcher Exchange from Faculdade de Medicina de Ribeirao Preto, Brazil
British Council - Manchester
2009 - 2009
- DPFS Resource Request (University of Glasgow)
Medical Research Council
2009 - 2011
- 3 Tesla Cardiac Magnetic Resonance Imaging Facility at the BHF Glasgow Cardiovascular Research Centre
British Heart Foundation
2008 - 2009
- A combined approach targeting oxidative stress and apoptosis in stroke
British Heart Foundation
2008 - 2012
- Collaborative strategy for a definitive genome scan in essential hypertension: high fidelity phenotyping and "hypercontrols"
British Heart Foundation
2008 - 2011
- Genomics and proteomics of hypertension and its vascular complications: the pathwayomic strategies.
British Heart Foundation
2008 - 2011
- Assessment of endothelial function in pregnancy: evaluation of a non-invasive method to analyse flow-mediated vasodilation
NHS Greater Glasgow and Clyde Endowment Funds
2008 - 2010
- QTL [Quantitative Trait Locus] Mapping using a rat heterogeneous stock
Wellcome Trust
2008 - 2011
- High throughput collaborative analysis of cardiovascular genes in 6000 hypertensives and 6000 controls
British Heart Foundation
2008 - 2009
- Does ACE2 have a protective role in the heart? Systematic analysis of ACE2 in a disease model
British Heart Foundation
2007 - 2010
- Biomarkers for battling chronic diseases
Scottish Funding Council
2007 - 2012
- Variation in promoter function in CYP11B2 and regulation of aldosterone secretion in cardiovascular disease
Medical Research Council
2007 - 2010
- VisGenome: visualisation of single and comparative genome representations
Wellcome Trust
2007 - 2008
- Does variation in response to oral antiplatelet therapy influence outcome in patients undergoing PCI [Percutaneous Coronary Intervention]?
NHS Greater Glasgow and Clyde Endowment Funds
2007 - 2007
- Characterising the ischaemic penumbra in the SIIRSP and WKY following focal cerebral ischaemia
Neurosciences Foundation
2006 - 2007
- Hydralazine in heart failure - a study of the mechanisms of action in human blood vessels
British Heart Foundation
2006 - 2009
- Research Councils UK academic fellowships - adrenal and extra-adrenal production of corticosteroids
Engineering and Physical Sciences Research Council
2006 - 2011
- EURATools - European Rat Tools for Functional Genomics
European Commission
2006 - 2010
- Acidic fibroblast growth factor gene and human hypertension - from positional cloning to functional studies
Scottish Executive Health Department
2005 - 2006
- Endothelial Repair:Relationships with Human Coronary Atheroma in Vivo
British Heart Foundation
2005 - 2006
- Targeted gene therapy for cardiovascular disease
Medical Research Council
2005 - 2008
- BRIGHT study - early results and future prospects
Medical Research Council
2005 - 2010
- Sustained gene delivery in vivo using vascular-targeted AAV vectors
British Heart Foundation
2005 - 2008
- High Fidelity Phenotyping combined with genomics, proteomics and metabonomics close to the patient
British Heart Foundation
2004 - 2008
- Adipocyte lipolysis as a candidate pathway in the pathogenesis of pre-eclampsia
British Heart Foundation
2004 - 2008
- Functional genomic analysis of the glutathione-S-transferase mu type 1, positional candidate gene for hypertension
British Heart Foundation
2004 - 2007
- Genetic Health in the 21st Century Project
Scottish Funding Council
2004 - 2009
- Development of systemic gene delivery to the kidney
Kidney Research UK
2003 - 2005
- Development and evaluation of novel adeno-associated viral vectors for long term gene therapy
Medical Research Council
2003 - 2006
- Development of a novel adenovirus-based, targetable vector for selective in vivo gene delivery
British Heart Foundation
2003 - 2005
- Genetic determinants of hypertension and its vascular complications: from positional candidate genes to vascular gene transfer strategies
British Heart Foundation
2003 - 2008
- The British genetics of hypertension study - application to enhance TDT and control recruitment for fine mapping genes for hypertension
British Heart Foundation
2003 - 2005
- The Y Chromosome and Genetic Hypertension
North Glasgow University Hospitals NHS Trust
2002 - 2005
- Cardiovascular Functional genomics - Translating experimental work to human disease
Wellcome Trust
2002 - 2009
- Y chromosome B2-adrenergic receptor gene and cardiovascular traits from intermediate phenotypes to gene-gene interactions
Wellcome Trust
2002 - 2005
- Scottish Centre for Research into e-Science Data, Information and Knowledge Transformation (eDIKT)
Scottish Funding Council
2000 - 2008
Additional information
Editorial Board
- 2015 - present: Arterial Hypertension - Editorial Board
- 2012 - present: Hypertension - Editor in Chief
- 2011 - present: Global Heart - Editorial Board
- 2009 - present: The Asia-Pacific Journal of General Practice - Editorial Board
- 2009 - 2011: Journal of Hypertension - Associate Editor
- 2006 - present: Internal and Emergency Medicine - Editorial Board
- 2006 - present: American Journal of Hypertension - Editorial Board
- 2006 - present: Journal of the American Society of Hypertension - Editorial Board
- 2005 - 2007: Faculty of 1000 Biology - Editorial Board
- 2004 - 2008: Clinical Science - Editor-in-Chief
- 2004 - present: Current Hypertension Reviews - Editorial Board
- 2004 - present: Cell Metabolism - Editorial Board
- 2001 - present: Blood Pressure - Editorial Board
- 2001 - 2010: Journal of Molecular Medicine - Editorial Board
- 2000 - 2003: Clinical Science - Associate Editor
- 1999 - present: Physiological Genomics - Editorial Board
- 1999 - 2000: Clinical Science - Rapid Communication Editor
- 1998 - present: Hypertension - Editorial Board
- 1997 - 2008: Clinical Science - Editorial Board
- 1996: Hypertension - Guest Editor -(Genetic Symposium)
- 1994 - 1997: Journal of Hypertension - Editorial Board
Prizes, Awards and Distinctions
- 2019: Fitzgerald Peel Lecture - Scottish Society of Physicians 61st Annual Meeting
- 2019: Pioneering Precision Medicine in Scotland - TEDxGlasgow
- 2018: Sir Derrick Melville Dunlop Lecture - Royal College of Physicians of Edinburgh
- 2017: The Pickering Lecture, British Hypertension Society
- 2016: Visiting Professorship, Chinese University of Hong Kong
- 2016: D.B.E. for services to cardiovascular and medical sciences
- 2015: Visiting Professorship, Sun Yat Sen University, Guangzhou, China
- 2014: The Robert Tigerstedt Award & Lecture, Helsinki
- 2013: The William Harvey Outstanding Contribution to Science Award and Lecture, London
- 2010: Fellowship of the Society of Biology
- 2010: Sackler Foundation - Sackler Fellowship and Lecture
- 2009: The Royal Philosophical Society of Glasgow - The Graham Lecture and Medal
- 2008: European Society of Hypertension - Bjorn Folkow Award and Lecture
- 2007: Lord Provost - The Lord Provost's Special Award for 2006, for the contribution and commitment to the health of Glasgow
- 2006: Scotswoman of the Year
- 2005: OBE
- 2005: High Blood Pressure Research Council of Australia - RD Wright Award and Lecture
- 2004: American Heart Association - Arthur Corcoran Award and Lecture
- 2003: Canadian Hypertension Society - Presidential Award and Lecture
- 2003: Belgian Hypertension Society - The Lecturer of the Year
- 1990: University of Michigan - Visiting Associate Professor
Professional Learned Society
- 2003 - present: Royal Society of Edinburgh - FRSE
- 2001 - present: Academy of Medical Sciences - FMedSci
- 1996 - present: American Heart Association - International Fellowship of the Council of High Blood Pressure Research of the American Heart Association (F.A.H.A)
Research Fellowship
- 1993 - 1998: British Heart Foundation - Senior Research Fellowship
