Hypertension

We study all aspects of hypertension (high blood pressure) from understanding the pathophysiology to describing the epidemiology and developing new potential treatments. 

Staff

Publications

2024

Greenlees, C., Hosseinzadeh, S., Delles, C., Mcginnigle, E. (2024) Hypertension evaluation and management in new young patients: are we doing our female patients a disservice? Blood Pressure, 33, (doi: 10.1080/08037051.2024.2387909)

McGinley, K. A., Lucas-Herald, A., Connelly, P., Delles, C. (2024) Gender-affirming hormone therapy: effects on cardiovascular risk and vascular function. Endocrine Connections,

Main, A., Mary, S., Sin, Y. Y., Wright, T. A., Ling, J., Blair, C. M., Smith, G. L., Fuller, W., Baillie, G. S. (2024) SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline. International Journal of Biochemistry and Cell Biology, 176, (doi: 10.1016/j.biocel.2024.106668)

Dieden, A., Girerd, N., Ottosson, F., Molvin, J., Pareek, M., Melander, O., Bachus, E., Råstam, L., Lindblad, U., Daka, B., Leósdóttir, M., Nilsson, P. M., Olsen, M. H., Clark, A. L., Cleland, J. G.F., Delles, C., González, A., Lamiral, Z., Duarte, K., Rossignol, P., Zannad, F., Gudmundsson, P., Jujić, A., Magnusson, M. (2024) Proteomic biomarkers and pathway analysis for progression to heart failure in three epidemiological representative cohorts. European Journal of Heart Failure, (doi: 10.1002/ejhf.3502)

Foley, P.W., Kalra, P.R., Cleland, J.G.F., Petrie, M.C., Kalra, P.A., Squire, I., Campbell, P., Chapman, C., Donnelly, P., Graham, F., Hannah, A., Lang, N.N., Matthews, I., Leslie, S.J., Pellicori, P., Piper, S., Ray, R., Savage, H.O., Spencer, C., Walsh, J., Wong, Y., Ford, I. (2024) Effect of correcting iron deficiency on the risk of serious infection in heart failure insights from the IRONMAN trial. European Journal of Heart Failure, (doi: 10.1002/ejhf.3504)

Riddell, A., Flynn, A., Bergugnat, H., Dowsett, L. B., Miller, A. A. (2024) SDMA as a marker and mediator in cerebrovascular disease. Clinical Science, 138, pp. 1305-1323. (doi: 10.1042/CS20241021)

Ho, F., Allan, M., Shao, H., Man, K. K.C., Jani, B. D., Lyall, D., Hastie, C., Fleming, M., Mackay, D., Cleland, J. G.F., Delles, C., Dundas, R., Lewsey, J., Ip, P., Wong, I., Welsh, P., Pearce, A., Wright, C. M., Minnis, H., Katikireddi, V., Pell, J. P. (2024) Maternal and pregnancy factors contributing to the association between area deprivation and infant mortality in England: a retrospective cohort study. Lancet Regional Health - Europe, (doi: 10.1016/j.lanepe.2024.101075)

Lee, M., Petrie, M. C., Cleland, J. G.F., Donnelly, P., Francis, M., Hannah, A., Japp, A. G., Labinjoh, C., Lang, N. N., Mainsty, C., Petrie, C. J., Piper, S. E., Williams, S. G., Ford, I., Kalra, P. R., IRONMAN Trial Investigators, (2024) Administration of ferric derisomaltose for iron deficiency and heart failure during hospital admission or at the clinic – insights from the IRONMAN trial. European Journal of Heart Failure, 26, pp. 2293-2295. (doi: 10.1002/ejhf.3394)

Beazer, J. D., Sillars, A., Beck, S., Christoffersen, C., Ferraz, M. J., Mulder, M., Graham, D., Karlsson, H., Ljunggren, S. A., Gill, J. M. R., Freeman, D. J. (2024) Favourable HDL composition in endurance athletes is not associated with changes in HDL in vitro antioxidant and endothelial anti-inflammatory function. Bioscience Reports, (doi: 10.1042/BSR20241165)

Zhou, M., Mary, S., Delles, C., Padmanabhan, S., Graham, D., McBride, M. W., Dominiczak, A. (2024) Insights into uromodulin and blood pressure. Current Hypertension Reports, (doi: 10.1007/s11906-024-01317-0)

Morrow, A. et al. (2024) Zibotentan in microvascular angina: a randomized, placebo-controlled, crossover trial. Circulation, (doi: 10.1161/CIRCULATIONAHA.124.069901)

McNeilly, S. et al. (2024) Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage. EBioMedicine, 107, (doi: 10.1016/j.ebiom.2024.105315)

Lipina, T., Li, S., Petrova, E. S., Amstislavskaya, T. G., Cameron, R. T., Elliott, C., Gondo, Y., McGirr, A., Mullins, J. G.L., Baillie, G. S., Woodgett, J. R., Clapcote, S. J. (2024) PDE4B missense variant increases susceptibility to post-traumatic stress disorder-relevant phenotypes in mice. Journal of Neuroscience,

McLaren, J., Gao, X., Ghouri, N., Freeman, D. J., Richardson, J., Sattar, N., Gill, J. M.R. (2024) Weight gain leads to greater adverse metabolic responses in South Asian compared with white European men: the GlasVEGAS study. Nature Metabolism, 6, pp. 1632-1645. (doi: 10.1038/s42255-024-01101-z)

Thongyim, S., Wright, T. A., Sattayawat, P., Kaewkod, T., Baillie, G. S., Tragoolpua, Y., Jangsutthivorawat, S., Panya, A. (2024) Clinacanthus nutans extract lowers periodontal inflammation under high-glucose conditions via inhibiting NF-κB signaling pathway. Frontiers in Pharmacology, 15, (doi: 10.3389/fphar.2024.1410419)

Elyan, B. M.P., Sullivan, M. K., Hedley, J., De La Mata, N., Webster, A. C., Venugopal, B., Jones, R. J., Lang, N. N., Mark, P. B., Lees, J. S. (2024) The impact of VEGF signalling pathway inhibitors and/or immune checkpoint inhibitors on kidney function over time: a single centre retrospective analysis. BJC Reports, 2, (doi: 10.1038/s44276-024-00081-7)

Richardson, S. H., Mackenzie, J., Thekkethil, N., Feng, L., Lee, J., Berry, C., Hill, N., Luo, X., Gao, H. (2024) Cardiac perfusion coupled with a structured coronary network tree. Computer Methods in Applied Mechanics and Engineering, 428, (doi: 10.1016/j.cma.2024.117083)

Carberry, J., Petrie, M. C., Lee, M. M.Y., Brooksbank, K., Campbell, R. T., Good, R., Jhund, P. S., Kellman, P., Lang, N. N., Mangion, K., Mark, P. B., McConnachie, A., McMurray, J. J.V., Meyer, B., Orchard, V., Shaukat, A., Watkins, S., Welsh, P., Sattar, N., Berry, C., Docherty, K. F. (2024) Empagliflozin to prevent progressive adverse remodelling after myocardial infarction (EMPRESS-MI): rationale and design. ESC Heart Failure, 11, pp. 2001-2012. (doi: 10.1002/ehf2.14830)

Docherty, K. F., McMurray, J. J.V., Kalra, P., Cleland, J. G.F., Lang, N. N., Petrie, M. C., Robertson, M., Ford, I. (2024) Intravenous iron and SGLT2 inhibitors in iron-deficient patients with heart failure and reduced ejection fraction. ESC Heart Failure, 11, pp. 1875-1879. (doi: 10.1002/ehf2.14742)

Murphy, R. P., Hankey, G. J., Judge, C., Reddin, C., Langhorne, P., López-Jaramillo, P., Mondo, C., Xavier, D., Wang, X., Yusuf, S., O'Donnell, M. (2024) Markers of periodontal disease and risk of stroke: INTERSTROKE case-control study. Journal of Stroke and Cerebrovascular Diseases, 33, (doi: 10.1016/j.jstrokecerebrovasdis.2024.107803)

Li, C., Wu, J., Lin, J., Wu, Y., Xu, R., Quian, J., Hau, W. K., Barbato, E., Johnson, N. J., Hennigan, B., Berry, C., Oldroyd, K. G., Song, L., Ge, J. (2024) Validation of a new non-hyperemic physiological index: the constant-resistance ratio (cRR) Journal of Invasive Cardiology, 36, (doi: 10.25270/jic/24.00047)

McCallum, L., Lip, S., McConnachie, A., Brooksbank, K., MacIntyre, I., Doney, A., Llano, A., Aman, A., Caparrotta, T. M., Ingram, G., Mackenzie, I. S., Dominiczak, A. F., MacDonald, T. M., Webb, D. J., Padmanabhan, S. (2024) UMOD genotype-dependent effects of Torasemide on ambulatory blood pressure: a multicentre genotype-blinded trial. Hypertension, (doi: 10.1161/HYPERTENSIONAHA.124.23122)

Delles, C., Setjiadi, D., Geddes, C. (2024) Blood pressure measurement technique in clinical practice. Research Square, (doi: 10.21203/rs.3.rs-4635130/v1)

Shead, K. D., Huethorst, E., Burton, F., Lang, N., Myles, R. C., Smith, G. L. (2024) Human induced pluripotent stem cell derived cardiomyocytes for pre-clinical cardiotoxicity screening. JACC: CardioOncology,

Kelham, M., Vyas, R., Ramaseshan, R., Rathod, K., de Winter, R. J., de Winter, R. W., Bendz, B., Thiele, H., Hirlekar, G., Morici, N., Myat, A., Michalis, L. K., Sanchis, J., Kunadian, V., Berry, C., Mathur, A., Jones, D. A. (2024) Non-ST-elevation acute coronary syndromes with previous coronary artery bypass grafting: a meta-analysis of invasive vs. conservative management. European Heart Journal, 45, pp. 2380-2391. (doi: 10.1093/eurheartj/ehae245)

Berry, C., Sidik, N. P., McEntegart, M. B., CorCTA Investigators, (2024) Response by Berry et al to letter regarding article, "Invasive Endotyping in Patients With Angina and No Obstructive Coronary Artery Disease: A Randomized Controlled Trial". Circulation, 150, pp. e5-e6. (doi: 10.1161/CIRCULATIONAHA.124.069708)

Collet, C. et al. (2024) A systematic approach to the evaluation of the coronary microcirculation using bolus thermodilution: CATH CMD. Journal of the Society for Cardiovascular Angiography and Interventions, 3, (doi: 10.1016/j.jscai.2024.101934)

Sin, Y. Y., Cameron, R. T., Schepers, M., MacLeod, R., Wright, T. A., Paes, D., van den Hove, D., Willems, E., Vanmierlo, T., Prickaerts, J., Blair, C. M., Baillie, G. S. (2024) Beta-amyloid interacts with and activates the longform phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability. FEBS Letters, 598, pp. 1591-1604. (doi: 10.1002/1873-3468.14902)

Shead, K. D., Salyahetdinova, V., Baillie, G. S. (2024) Charting the importance of Filamin A posttranslational modifications. Biochemical Journal, 481, pp. 865-881. (doi: 10.1042/BCJ20240121)

Gardner, O. F.W., Bai, T., Baillie, G. S., Ferretti, P. (2024) Phosphodiesterase 4D activity in acrodysostosis-associated neural pathology: too much or too little? Brain Communications, (doi: 10.1093/braincomms/fcae225)

Kulkarni, S., Faconti, L., Partridge, S., Delles, C., Glover, M., Lewis, P., Gray, A., Hodson, E., Macintyre, I., Maniero, C., McEniery, C. M., Sinha, M. D., Walsh, S. B., Wilkinson, I. B. (2024) Investigation and management of young-onset hypertension: British and Irish Hypertension Society position statement. Journal of Human Hypertension, (doi: 10.1038/s41371-024-00922-5)

Canning, J., Strawbridge, R. J., Miedzybrodzka, Z., Marioni, R. E., Melbye, M., Porteous, D. J., Hurles, M. E., Sattar, N., Sudlow, C. L.M., Collins, R., Padmanabhan, S., Pell, J. P. (2024) Methods applied to neonatal dried blood spot samples for secondary research purposes: a scoping review. Critical Reviews in Clinical Laboratory Sciences, (doi: 10.1080/10408363.2024.2360996)

Rankin, S., Fountain, C., Gemmell, A., Quinn, D., Henderson, A., McClure, J., Small, S., Venugopal, B., McKay, P., Slomka, P. J., Colville, D., Petrie, M. C., Meléndez, G. C., Lang, N. N. (2024) Arterial effects of anthracycline: structural and inflammatory assessments in non-human primates and lymphoma patients using 18F-FDG positron emission tomography. bioRxiv, (doi: 10.1101/2024.05.30.596741)

Ang, D. T.Y., Abraham, G., Sim, K. Y.T., Sidik, N. P., Anwar, M., Ford, T. J., Berry, C., Hoole, S. P. (2024) Comparing pressure-bounded versus thermodilution-derived coronary flow reserve in unobstructed coronary arteries. American Journal of Cardiology, 222, pp. 165-166. (doi: 10.1016/j.amjcard.2024.05.014)

Tran, T. Q. B., Lip, S., du Toit, C., Kalaria, T. K., Bhaskar, R. K., O'Neil, A. Q., Graff, B., Hoffmann, M., Szyndler, A., Polonis, K., Wolf, J., Reddy, S., Narkiewicz, K., Dasgupta, I., Dominiczak, A. F., Visweswaran, S., McCallum, L., Padmanabhan, S. (2024) Assessing machine learning for diagnostic classification of hypertension types identified by ambulatory blood pressure monitoring. CJC Open, 6, pp. 798-804. (doi: 10.1016/j.cjco.2024.03.005)

Padmanabhan, S., Delles, C., Dominiczak, A. F. (2024) Beyond genome-wide scans: advancing hypertension genomics into the future. Hypertension, 81, pp. 1186-1189. (doi: 10.1161/HYPERTENSIONAHA.124.21371)

Ang, D. T.Y., Carrick, D., Kamdar, A., Sykes, R., McGeoch, R. J., Collison, D., McConnachie, A., Berry, C. (2024) Intracoronary adenosine–derived coronary flow reserve and index of microvascular resistance. Circulation: Cardiovascular Interventions, 17, (doi: 10.1161/circinterventions.123.013667)

Curtain, J. P., Talebi, A., McIntosh, A., McConnachie, A., O’Donnell, J., Welsh, P., Osmanska, J., Lee, M. M.Y., Sonecki, P., Akl, T., Seo, J., Gopinathan, V., Hurwitz, J., Thiagarajan, S., Pettit, S., Kalra, P. R., Patel, R. K., Mark, P. B., Lang, N. N., McMurray, J. J.V., Petrie, M. C., Gardner, R. S., Jhund, P. S. (2024) Measuring congestion with a non-invasive monitoring device in heart failure and haemodialysis: CONGEST-HF. European Journal of Heart Failure, 26, pp. 1383-1392. (doi: 10.1002/ejhf.3290)

Murphy, R. et al. (2024) Variations in the prevalence of atrial fibrillation, and in the strength of its association with ischemic stroke, in countries with different income levels: INTERSTROKE case–control study. International Journal of Stroke, 19, pp. 559-568. (doi: 10.1177/17474930241227783)

Docherty, N. G., Delles, C., López-Hernández, F. J. (2024) Reframing acute kidney injury as a pathophysiological continuum of disrupted renal excretory function. Acta Physiologica, (doi: 10.1111/apha.14181)

Lawson, C. A. et al. (2024) Long COVID and cardiovascular disease: a prospective cohort study. Open Heart, 11, (doi: 10.1136/openhrt-2024-002662)

Loughrey, C. et al. (2024) A novel ryanodine receptor 2 inhibitor, M201-A, enhances natriuresis, renal function and lusi-inotropic action: Pre-clinical and phase I study. British Journal of Pharmacology, 181, pp. 3401-3419. (doi: 10.1111/bph.16379)

Lechner, I., Reindl, M., Stiermaier, T., Tiller, C., Holzknecht, M., Oberhollenzer, F., von der Emde, S., Mayr, A., Feistritzer, H.-J., Carberry, J., Carrick, D., Bauer, A., Thiele, H., Berry, C., Eitel, I., Metzler, B., Reinstadler, S. J. (2024) Clinical outcomes associated with various microvascular injury patterns identified by CMR after STEMI. Journal of the American College of Cardiology, 83, pp. 2052-2062. (doi: 10.1016/j.jacc.2024.03.408)

Eerdekens, R., El Farissi, M., De Maria, G. L., van Royen, N., van ‘t Veer, M., van Leeuwen, M. A.H., Hoole, S. P., Marin, F., Carrick, D., Tonino, P. A.L., Pijls, N. H.J., Fineschi, M., Oldroyd, K. G., Berry, C., Banning, A. P., Fearon, W. F., Zimmermann, F. M. (2024) Prognostic value of microvascular resistance reserve after percutaneous coronary intervention in patients with myocardial infarction. Journal of the American College of Cardiology, 83, pp. 2066-2076. (doi: 10.1016/j.jacc.2024.02.052)

Collet, C. et al. (2024) Influence of pathophysiological patterns of coronary artery disease on immediate percutaneous coronary intervention outcomes. Circulation, (doi: 10.1161/circulationaha.124.069450)

Abraham, G. R., Berry, C., Fu, Q., Hoole, S. P., Weir-McCall, J. R. (2024) Differences in quantitative myocardial perfusion mapping by CMR at 1.5 T and 3 T. American Heart Journal Plus: Cardiology Research and Practice, 41, (doi: 10.1016/j.ahjo.2024.100388)

Olivera, S., Graham, D. (2024) Modelling pre-eclampsia and its cardiovascular effects. Nature Reviews Cardiology, 21, (doi: 10.1038/s41569-024-01006-0)

Kobayashi, M., Ferreira, J. P., Kevin, D., Bresso, E., Huttin, O., Bozec, E., Brunner La Rocca, H.-P., Delles, C., Clark, A. L., Edelmann, F., González, A., Heymans, S., Pellicori, P., Petutschnigg, J., Verdonschot, J. A.J., Rossignol, P., Cleland, J. G.F., Zannad, F., Girerd, N. (2024) Proteomic profiles of left atrial volume and its influence on response to spironolactone: findings from the HOMAGE trial and STANISLAS cohort. European Journal of Heart Failure, 26, pp. 1231-1241. (doi: 10.1002/ejhf.3202)

Cooke, S. F., Wright, T. A., Sin, Y. Y., Ling, J., Kyurkchieva, E., Phanthaphol, N., McSkimming, T., Herbert, K., Rebus, S., Biankin, A. V., Chang, D. K., Baillie, G. S., Blair, C. M. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, (doi: 10.1038/s41598-024-59451-3)

Rankin, S., Elyan, B., Jones, R., Venugopal, B., Mark, P. B., Lees, J. S., Petrie, M. C., Lang, N. N. (2024) Cardiovascular eligibility criteria and adverse event reporting in combined immune checkpoint and VEGF inhibitors trials. JACC: CardioOncology, 6, pp. 267-279. (doi: 10.1016/j.jaccao.2023.12.010)

Glen, C., Morrow, A., Roditi, G., Hopkins, T., Macpherson, I., Stewart, P., Petrie, M. C., Berry, C., Epstein, F., Lang, N. N., Mangion, K. (2024) Cardiovascular sequalae of trastuzumab and anthracycline in long-term survivors of breast cancer. Heart, 110, pp. 650-656. (doi: 10.1136/heartjnl-2023-323437)

O’Callaghan, G., Fahy, M., O’Meara, S., Chawke, M., Waldron, E., Corry, M., Gallagher, S., Coyne, C., Lynch, J., Kennedy, E., Walsh, T., Cronin, H., Hannon, N., Fallon, C., Williams, D. J., Langhorne, P., Galvin, R., Horgan, F. (2024) Transitioning to home and beyond following stroke: a prospective cohort study of outcomes and needs. BMC Health Services Research, 24, pp. 449. (doi: 10.1186/s12913-024-10820-8)

Austin, R., Ellison, S., Kavuncu, D., Kinsey, L., Loftus, N. W., Masters, H., Richardson, J., Ting, F. F., Bernhardt, L. (2024) The BANCC research forum: supporting cardiac nurses to develop research and academic skills. British Journal of Cardiac Nursing, 19, (doi: 10.12968/bjca.2024.0022)

Hanson Ng, Y. Y., Dora, K. A., Lemmey, H. A. L., Lin, J., Alden, J., Wallis, L., Donovan, L., Shorthose, O., Leiper, F. C., Leiper, J., Garland, C. J. (2024) Asymmetric dimethylarginine enables depolarizing spikes and vasospasm in mesenteric and coronary resistance arteries. Hypertension, 81, pp. 764-775. (doi: 10.1161/HYPERTENSIONAHA.123.22454)

Yang, Y., Husmeier, D., Gao, H., Berry, C., Carrick, D., Radjenovic, A. (2024) Automatic detection of myocardial ischaemia using generalisable spatio-temporal hierarchical Bayesian modelling of DCE-MRI. Computerized Medical Imaging and Graphics, 113, (doi: 10.1016/j.compmedimag.2024.102333)

Neupane, D., Mukhtar, Q., Krajan Pardo, E. K., Acharya, S. D., Delles, C., Sharman, J. E., Cobb, L., Lackland, D. T., Moran, A., Weber, M. A., Olsen, M. H. (2024) Emerging Authors Program for building cardiovascular disease prevention and management research capacity in low- and middle-income countries: a collaboration of the U.S. Centers for Disease Control and Prevention, the Lancet Commission on Hypertension Group, Resolve to Save Lives, and the World Hypertension League. Journal of Human Hypertension, 38, pp. 380-381. (doi: 10.1038/s41371-023-00880-4)

Alsanosi, S. M., Padmanabhan, S. (2024) Potential applications of artificial intelligence (AI) in managing polypharmacy in Saudi Arabia: a narrative review. Healthcare, 12, (doi: 10.3390/healthcare12070788)

Sani, R. N., Connelly, P. J., Toft, M., Rowa-Dewar, N., Delles, C., Gasevic, D., Karaye, K. M. (2024) Rural-urban difference in the prevalence of hypertension in West Africa: a systematic review and meta-analysis. Journal of Human Hypertension, 38, pp. 352-364. (doi: 10.1038/s41371-022-00688-8)

Lim, M. W. S., Lucas-Herald, A. K., Mason, A., Delles, C., Connelly, P. J. (2024) Sex differences in the cardiovascular effects of GnRH analogues. Journal of Endocrinology, 261, (doi: 10.1530/JOE-23-0309)

Rossitto, G., Bertoldi, G., Rutkowski, J. M., Mitchell, B. M., Delles, C. (2024) Sodium, interstitium, lymphatics, and hypertension - A tale of hydraulics. Hypertension, 81, pp. 727-737. (doi: 10.1161/HYPERTENSIONAHA.123.17942)

Mavrogeorgis, E., Kondyli, M., Mischak, H., Vlahou, A., Siwy, J., Rossing, P., Campbell, A., Mels, C. M.C., Delles, C., Staessen, J. A., Latosinska, A., Persu, A. (2024) Multiple urinary peptides are associated with hypertension: a link to molecular pathophysiology. Journal of Hypertension, (doi: 10.1097/HJH.0000000000003726)

Wang, X. et al. (2024) Tobacco use and risk of acute stroke in 32 countries in the INTERSTROKE study: a case-control study. eClinicalMedicine, 70, (doi: 10.1016/j.eclinm.2024.102515)

Kite, T. A. et al. (2024) Complex percutaneous coronary intervention in patients unable to undergo coronary artery bypass grafting during the COVID-19 pandemic: insights from the UK-ReVasc Registry. Journal of Invasive Cardiology, (doi: 10.25270/jic/24.00030)

Haag, L., Richardson, J., Haig, C., Cunningham, Y., Fraser, H., Brosnahan, N., Ibbotson, T., Omerod, J., White, C., McIntosh, E., O'Donnell, K., Sattar, N., McConnachie, A., Lean, M., Blane, D., Combet, E. (2024) Baseline characteristics in the Remote Diet Intervention to REduce long-COVID Symptoms Trial (ReDIRECT) NIHR Open Research, 4, (doi: 10.3310/nihropenres.13522.1)

Setjiadi, D., Delles, C., Boutouyrie, P., Bruno, R. M. (2024) Inappropriate Pulse Wave Velocity to Blood Pressure Level: Definition and Clinical Determinants.

McCallum, L., Lip, S., Rostron, M., Hanna, R., Salimin, N. B. P. M., Nichol, S., Padmanabhan, S. (2024) OPTIMA-BP: empOwering PaTients in MAnaging Blood Pressure – protocol for a randomised parallel group study comparing use of Kvatchii web-based patient education portal as an addition to home blood pressure monitoring. Open Heart, 11, (doi: 10.1136/openhrt-2023-002535)

Sykes, R., Hanna, R., Berry, C. (2024) Prognostic importance of fractional flow reserve and left ventricular systolic dysfunction after percutaneous coronary intervention. JACC: Asia, 4, pp. 241-243. (doi: 10.1016/j.jacasi.2023.12.002)

Gulliver, C., Busiau, T., Byrne, A., Findlay, J. E., Hoffmann, R., Baillie, G. (2024) cAMP-phosphodiesterase 4D7 (PDE4D7) forms a cAMP signalosome complex with DHX9 and is implicated in prostate cancer progression. Molecular Oncology, 18, pp. 707-725. (doi: 10.1002/1878-0261.13572)

Bosserdt, M. et al. (2024) Age and computed tomography and invasive coronary angiography in stable chest pain: a prespecified secondary analysis of the discharge randomized clinical trial. JAMA Cardiology, 9, pp. 346-356. (doi: 10.1001/jamacardio.2024.0001)

Morrow, A. J. et al. (2024) Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization. Communications Medicine, 4, (doi: 10.1038/s43856-024-00455-5)

Kelham, M., Vyas, R., Rameseshan, R., Rathod, K., de Winter, R.J., de Winter, R.W., Bendz, B., Thiele, H., Hirlekar, G., Morici, N., Myat, A., Michalis, L., Sanchis, J., Kunadian, V., Berry, C., Mathur, A., Jones, D. (2024) 100.03 Routine Invasive Versus Conservative Management of Non-ST Elevation Acute Coronary Syndromes in Patients With Previous Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis of Randomised Clinical Trials. (doi: 10.1016/j.jcin.2024.01.082)

Desson, Z., Sharman, J. E., Searles, A., Schutte, A. E., Delles, C., Olsen, M. H., Ordunez, P., Hure, A., Morton, R., Figtree, G., Webster, J., Jennings, G., Redfern, J., Nicolls, S., McNamara, M., Deeming, S., Doyle, K., Ramanathan, S. (2024) Improving the accuracy of blood pressure measuring devices in Australia: a modelled return on investment study. Journal of Human Hypertension, 38, pp. 177-186. (doi: 10.1038/s41371-023-00866-2)

MacKenzie, S. M., Birch, L. A., Lamprou, S., Rezvanisanijouybari, P., Fayad, M., Zennaro, M.-C., Davies, E. (2024) MicroRNAs in aldosterone production and action. Elsevier

Olowoyo, P. et al. (2024) Priorities to reduce the burden of hypertension in Africa through ACHIEVE. Lancet Global Health, 12, pp. e192-e193. (doi: 10.1016/S2214-109X(23)00540-5)

Mary, S., Conti-Ramsden, F., Boder, P., Parveen, H., Setjiadi, D., Fleminger, J., Brockbank, A., Graham, D., Bramham, K., Chappell, L. C., Delles, C. (2024) Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension. Journal of Nephrology, (doi: 10.1007/s40620-023-01830-6)

Kharlamov, A., Sherriff, N., Delles, C., van der Harst, P. (2024) Tackling cardiovascular healthcare disparities for LGBTQIA+ population: a call to action in the European Society of Cardiology. European Heart Journal, (doi: 10.1093/eurheartj/ehad882)

Sidik, N. P., Stanley, B., Sykes, R., Morrow, A. J., Bradley, C. P., Mcdermott, M., Ford, T., Roditi, G., Hargreaves, A., Stobo, D., Adams, J., Byrne, J., Mahrous, A., Young, R., Carrick, D., McGeoch, R., Corcoran, D., Lang, N. N., Heggie, R., Wu, O., McEntegart, M. B., McConnachie, A., Berry, C. (2024) Invasive endotyping in patients with angina and no obstructive coronary artery disease: a randomized controlled trial. Circulation, 149, pp. 7-23. (doi: 10.1161/CIRCULATIONAHA.123.064751)

Osmanska, J., Brooksbank, K., Docherty, K. F., Robertson, S., Wetherall, K., McConnachie, A., Hu, J., Gardner, R. S., Clark, A. L., Squire, I. B., Kalra, P. R., Jhund, P. S., Muntendam, P., McMurray, J. J.V., Petrie, M. C., Campbell, R. T. (2024) A novel, small-volume subcutaneous furosemide formulation delivered by an abdominal patch infusor device in patients with heart failure: results of two phase I studies. European Heart Journal: Cardiovascular Pharmacotherapy, 10, pp. 35-44. (doi: 10.1093/ehjcvp/pvad073)

Lyon, M., Fullerton, J. L., Kennedy, S., Work, L. M. (2024) Hypertension & dementia: pathophysiology & potential utility of antihypertensives in reducing disease burden. Pharmacology and Therapeutics, 253, (doi: 10.1016/j.pharmthera.2023.108575)

McFall, A., Graham, D., Nicklin, S. A., Work, L. M. (2024) Unscheduled changes in pre-clinical stroke model housing contributes to variance in physiological and behavioural data outcomes: a post hoc analysis. Brain and Neuroscience Advances, 8, (doi: 10.1177/23982128241238934)

Mair, F. S., Nickpour, F., Nicholl, B., Macdonald, S., Joyce, D. W., Cooper, J., Dickson, N., Leason, I., Abbasi, Q. H., Akin, I. F., Deligianni, F., Camacho, E., Downing, J., Garrett, H., Gray, M. J., Lowe, D. J., Imran, M. A., Padmanabhan, S., McCowan, C., Clarkson, P. J., Walker, L. E., Buchan, I. (2024) Developing SysteMatic: prevention, precision and equity by design for people living with multiple long-term conditions. Journal of Multimorbidity and Comorbidity, 14, pp. 1-9. (doi: 10.1177/26335565241272682)

Richardson, J., Raj, J. (2024) International nurse collaborations to improve cardiometabolic health: A professional visit report. British Journal of Cardiac Nursing, 19, (doi: 10.12968/bjca.2023.0098)

2023

Jackson, A. M., Macartney, M., Brooksbank, K., Brown, C., Dawson, D., Francis, M., Japp, A., Lennie, V., Leslie, S. J., Martin, T., Neary, P., Venakatasubramanian, S., Vickers, D., Weir, R. A., McMurray, J. J.V., Jhund, P. S., Petrie, M. C. (2023) A 20-year population study of peripartum cardiomyopathy. European Heart Journal, 44, pp. 5128-5141. (doi: 10.1093/eurheartj/ehad626)

Glen, C., Adam, S., Coats, C. J., Lang, N. N. (2023) Reply: Cardiotoxicity of BRAF/MEK inhibitors according to HFA/ICOS cardiotoxicity risk category. JACC: CardioOncology, 5, pp. 850. (doi: 10.1016/j.jaccao.2023.10.003)

Freeman-Jones, E., Miller, W. H., Work, L. M., Fullerton, J. L. (2023) Polypathologies and animal models of traumatic brain injury. Brain Sciences, 13, (doi: 10.3390/brainsci13121709)

Bagordo, D., Rossi, G. P., Delles, C., Wiig, H., Rossitto, G. (2023) The tangram of sodium and fluid balance: salt series. Hypertension, (doi: 10.1161/HYPERTENSIONAHA.123.19569)

Camargo, L. L., Wang, Y., Rios, F. J., McBride, M., Montezano, A. C., Touyz, R. M. (2023) Oxidative stress and endoplasmic reticular stress interplay in the vasculopathy of hypertension. Canadian Journal of Cardiology, 39, pp. 1874-1887. (doi: 10.1016/j.cjca.2023.10.012)

Richardson, J., Lee, M. (2023) Cardiovascular Screening Checks on Mongolian Nomads During the Khan Khentii Expedition, July 2023.

Connelly, P., Osmanska, J., Lee, M. M.Y., Delles, C., McEntegart, M. B., Byrne, J. (2023) A case report of myocardial infarction in a young transgender man with testosterone therapy? raising awareness on healthcare issues in the transgender community and a call for further research. European Heart Journal: Case Reports, 7, (doi: 10.1093/ehjcr/ytad562)

McErlane, J., McCall, P., Willder, J., Berry, C., Shelley, B. (2023) Cardiac biomarkers and right ventricular dysfunction are independently associated with one year mortality in patients with COVID-19 receiving mechanical ventilation: a prospective cohort study. CHEST Critical Care, 1, (doi: 10.1016/j.chstcc.2023.100015)

Sattar, N., Deanfield, J., Delles, C. (2023) Impact of intentional weight loss in cardiometabolic disease: what we know about timing of benefits on differing outcomes? Cardiovascular Research, 119, pp. e167-e171. (doi: 10.1093/cvr/cvac186)

Berry, C. et al. (2023) Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study. Heart and Mind, 7, pp. 235-245. (doi: 10.4103/hm.HM-D-23-00037)

Henriksen, P. A. et al. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148, pp. 1680-1690. (doi: 10.1161/CIRCULATIONAHA.123.064274)

Fullerton, J. L., Cosgrove, C. C., Rooney, R. A., Work, L. (2023) Extracellular vesicles and their microRNA cargo in ischaemic stroke. Journal of Physiology, 601, pp. 4907-4921. (doi: 10.1113/JP282050)

Murphy, C. N., Delles, C., Davies, E., Connelly, P. J. (2023) Cardiovascular disease in transgender individuals. Atherosclerosis, 384, (doi: 10.1016/j.atherosclerosis.2023.117282)

Martin, T. P., MacDonald, E. A., Bradley, A., Watson, H., Saxena, P., Rog-Zielinska, E. A., Raheem, A., Fisher, S., Elbassioni, A. A. M., Almuzaini, O., Booth, C., Campbell, M., Riddell, A., Herzyk, P., Blyth, K., Nixon, C., Zentilin, L., Berry, C., Braun, T., Giacca, M., McBride, M. W., Nicklin, S. R., Cameron, E. R., Loughrey, C. (2023) Ribonucleicacid interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction. Cardiovascular Research, 119, pp. 2663–2671-2663–2671. (doi: 10.1093/cvr/cvad107)

Bradley, C. P., Orchard, V., McKinley, G., Heggie, R., Wu, O., Good, R., Watkins, S., Lindsay, M., Eteiba, H., McGowan, J., McGeoch, R., Corcoran, D., Kellman, P., McConnachie, A., Berry, C. (2023) The coronary microvascular angina cardiovascular magnetic resonance imaging trial: rationale and design. American Heart Journal, 265, pp. 213-224. (doi: 10.1016/j.ahj.2023.08.067)

Irshad, Z., Lund, J., Sillars, A., Løvsletten, N. G., Gharanei, S., Salt, I. P., Freeman, D. J., Gill, J. M.R., Thoresen, G. H., Rustan, A. C., Zammit, V. A. (2023) The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background. FASEB Journal, 37, (doi: 10.1096/fj.202300960RR)

Gulliver, C., Huss, S., Semjonow, A., Baillie, G. S., Hoffmann, R. (2023) Loss of PDE4D7 expression promotes androgen independence, neuroendocrine differentiation, and alterations in DNA repair: implications for therapeutic strategies. British Journal of Cancer, 129, pp. 1462-1476. (doi: 10.1038/s41416-023-02417-5)

Glen, C., Adam, S., McDowell, K., Waterston, A., Tan, Y. Y., Petrie, M. C., Coats, C. J., Lang, N. N. (2023) Cardiotoxicity of BRAF/MEK inhibitors: a longitudinal study incorporating contemporary definitions and risk scores. JACC: CardioOncology, 5, pp. 628-637. (doi: 10.1016/j.jaccao.2023.04.004)

Kulkarni, S., Glover, M., Kapil, V., Abrams, S. M. L., Partridge, S., McCormack, T., Sever, P., Delles, C., Wilkinson, I. B. (2023) Management of hypertensive crisis: British and Irish Hypertension Society position document. Journal of Human Hypertension, 37, pp. 863-879. (doi: 10.1038/s41371-022-00776-9)

Gulliver, C., Baillie, G. S., Hoffmann, R. (2023) Reduced PDE4D7 in prostate cancer correlates with genomic downregulation within the upstream PDE4D coding region. Future Science OA, 9, (doi: 10.2144/fsoa-2023-0064)

Parsons, E. C., Baillie, G. S., Hoffmann, R. (2023) Revisiting the roles of cAMP signalling in the progression of prostate cancer. Biochemical Journal, 480, pp. 1599-1614. (doi: 10.1042/BCJ20230297)

Brown, A. D., Vergunst, K. L., Branch, M., Blair, C. M., Dupré, D. J., Baillie, G. S., Langelaan, D. N. (2023) Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor. Biochimica et Biophysica Acta: Molecular Cell Research, 1870, (doi: 10.1016/j.bbamcr.2023.119520)

Murray, E. C., Delles, C., Orzechowski, P., Renc, P., Sitek, A., Wagenaar, J., Guzik, T. J. (2023) Vascular phenotypes in early hypertension. Journal of Human Hypertension, 37, pp. 898-906. (doi: 10.1038/s41371-022-00794-7)

Meyer, B. J., Cortie, C., Dekker-Nitert, M., Barrett, H. L., Freeman, D. J. (2023) Women with gestational diabetes mellitus, controlled for plasma glucose level, exhibit maternal and fetal dyslipidaemia that may warrant treatment. Diabetes Research and Clinical Practice, 204, (doi: 10.1016/j.diabres.2023.110929)

Cui, L., Yang, B., Xiao, S., Gao, J., Baud, A., Graham, D., McBride, M., Dominiczak, A., Schafer, S., Aumatell, R. L., Mont, C., Teruel, A. F., Hübner, N., Flint, J., Mott, R., Huang, L. (2023) Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing. Genome Biology, 24, (doi: 10.1186/s13059-023-03060-2)

Richardson, J., Sattar, N., AlOzairi, E., Dawwas, B., Raj, J., Nappoe, A., Alshammari, S., Patil, S. (2023) Within an International Research Project, Visits to Collaborator Sites Informs Staff Training Needs, and Contributes to Successful Project Delivery.

de Beer, D., MC. Mels, C., Schutte, A., Delles, C., Mary, S., Mullen, W., Mischak, H., Kruger, R. (2023) Urinary peptidomics and pulse wave velocity: The African-PREDICT study. Journal of Proteome Research, 22, pp. 3282-3289. (doi: 10.1021/acs.jproteome.3c00347)

Lucas-Herald, A. K., Montezano, A. C., Alves-Lopes, R., Haddow, L., O'Toole, S., Flett, M., Lee, B., Amjad, S. B., Steven, M., McNeilly, J., Brooksbank, K., Touyz, R. M., Ahmed, S. F. (2023) Effects of sex hormones on vascular reactivity in boys with hypospadias. Journal of Clinical Endocrinology and Metabolism, (doi: 10.1210/clinem/dgad525)

Wright, T. A., Gemmell, A. O., Tejeda, G. S., Blair, C. M., Baillie, G. S. (2023) Cancer: phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target. International Journal of Biochemistry and Cell Biology, 162, (doi: 10.1016/j.biocel.2023.106453)

Sykes, R., Doherty, D., Morrow, A., Mangion, K., Rushd, A., Berry, C. (2023) NT-proBNP in patients presenting with myocardial infarction and non-obstructive coronary arteries without left ventricular systolic dysfunction. American Heart Journal Plus: Cardiology Research and Practice, 33, (doi: 10.1016/j.ahjo.2023.100311)

Keast, T., McErlane, J., Kearns, R., McKinlay, S., Raju, I., Watson, M., Robertson, K. E., Berry, C., Greenlaw, N., Ackland, G., McCall, P., Shelley, B. (2023) Study protocol for IMPRoVE: a multicentre prospective observational cohort study of the incidence, impact and mechanisms of perioperative right ventricular dysfunction in non-cardiac surgery. BMJ Open, 13, (doi: 10.1136/bmjopen-2023-074687)

Ranasinghe, S., Merz, C. N. B., Khan, N., Wei, J., George, M., Berry, C., Chieffo, A., Camici, P. G., Crea, F., Kaski, J. C., Marzilli, M., Gulati, M. (2023) Sex differences in Quality of Life in Patients with Ischemia with No Obstructive Coronary Artery Disease (INOCA): A Patient Self-Report Retrospective Survey from INOCA International. Journal of Clinical Medicine, 12, (doi: 10.3390/jcm12175646)

Montezano, A. C., Camargo, L. L., Mary, S., Neves, K. B., Rios, F. J., Stein, R., Lopes, R. A., Beattie, W., Thomson, J., Herder, V., Szemiel, A. M., McFarlane, S., Palmarini, M., Touyz, R. (2023) SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication. Scientific Reports, 13, (doi: 10.1038/s41598-023-41115-3)

Berry, C., McClure, J. D., Oldroyd, K. (2023) Death at 5-years in the DEFINE-FLAIR and iFR-SWEDEHEART trials: a pooled analysis. European Heart Journal,

Yeoh, S. E., Osmanska, J., Petrie, M. C., Brooksbank, K. J.M., Clark, A. L., Docherty, K. F., Foley, P. W.X., Guha, K., Halliday, C. A., Jhund, P. S., Kalra, P. R., McKinley, G., Lang, N. N., Lee, M. M.Y., McConnachie, A., McDermott, J. J., Platz, E., Sartipy, P., Seed, A., Stanley, B., Weir, R. A.P., Welsh, P., McMurray, J. J.V., Campbell, R. T. (2023) Dapagliflozin versus metolazone in heart failure resistant to loop diuretics. European Heart Journal, 44, pp. 2966-2977. (doi: 10.1093/eurheartj/ehad341)

Mangion, K., Morrow, A. J., Sykes, R., Kamdar, A., Bagot, C., Bruce, G., Connelly, P., Delles, C., Gibson, V. B., Gillespie, L., Hall Barrientos, P., Lennie, V., Roditi, G., Sattar, N., Stobo, D., Allwood-Spiers, S., McConnachie, A., Berry, C., CISCO-19 investigators, (2023) Post-COVID-19 illness and associations with sex and gender. BMC Cardiovascular Disorders, 23, (doi: 10.1186/s12872-023-03412-7)

Ohashi, H. et al. (2023) Fractional flow reserve guided stent optimisation in focal and diffuse coronary artery disease. Diagnostics, 13, (doi: 10.3390/diagnostics13152612)

Rigattieri, S., Barbato, E., Berry, C. (2023) Microvascular resistance reserve: a reference test of the coronary microcirculation? European Heart Journal, 44, pp. 2870-2872. (doi: 10.1093/eurheartj/ehad291)

Haag, L., Richardson, J., Cunningham, Y., Fraser, H., Brosnahan, N., Ibbotson, T., Ormerod, J., White, C., O'Donnell, K., Sattar, N., McConnachie, A., Lean, M. E. J., Blane, D. N., Combet, E. (2023) The remote diet intervention to reduce Long COVID symptoms trial (ReDIRECT): protocol for a randomised controlled trial to determine the effectiveness and cost-effectiveness of a remotely delivered supported weight management programme for people with Long COVID and excess weight, with personalised improvement goals. NIHR Open Research, 2, (doi: 10.3310/nihropenres.13315.2)

van de Vegte, Y. J. et al. (2023) Genetic insights into resting heart rate and its role in cardiovascular disease. Nature Communications, 14, (doi: 10.1038/s41467-023-39521-2)

Brown, C. E., Casey, H., Dominiczak, A. F., Kerr, S., Campbell, A., Delles, C. (2023) Impact of preeclampsia on cardiovascular events: an analysis of the Generation Scotland: Scottish family health study. Journal of Human Hypertension, 37, pp. 735-741. (doi: 10.1038/s41371-023-00812-2)

Sykes, R., Ang, D. T. Y., Berry, C. (2023) Invasive coronary microvascular function assessment: pharmacological versus exercise testing. Heart, 109, pp. 1130-1131. (doi: 10.1136/heartjnl-2023-322512)

Connelly, P. J., Delles, C. (2023) Journal of Human Hypertension special issue on sex and gender differences in hypertension. Journal of Human Hypertension, 37, pp. 587-588. (doi: 10.1038/s41371-023-00847-5)

Zorn, A., Baillie, G. (2023) Phosphodiesterase 7 as a therapeutic target – Where are we now? Cellular Signalling, 108, (doi: 10.1016/j.cellsig.2023.110689)

Casey, H., Dennehy, N., Fraser, A., Lees, C., McEniery, C. M., Scott, K., Wilkinson, I. B., Delles, C. (2023) Placental syndromes and maternal cardiovascular health. Clinical Science, 137, pp. 1211-1224. (doi: 10.1042/CS20211130)

Olivera, S., Graham, D. (2023) Sex differences in preclinical models of hypertension. Journal of Human Hypertension, 37, pp. 619-625. (doi: 10.1038/s41371-022-00770-1)

Bernhardt, J., Churilov, L., Dewey, H., Donnan, G., Ellery, F., English, C. K., Gao, L., Hayward, K. S., Horgan, F., Indredavik, B., Johns, H., Langhorne, P., Lindley, R., Martins, S., Mohd Ali, K., Middleton, S., Moodie, M., Pandian, J. D., Parsons, B., Robinson, T., Srikanth, V., Thijs, V. (2023) A phase III, multi-arm multi-stage covariate-adjusted response-adaptive randomized trial to determine optimal early mobility training after stroke (AVERT DOSE) International Journal of Stroke, 18, pp. 745-750. (doi: 10.1177/17474930221142207)

Lees, J. S., Dobbin, S. J.H., Elyan, B. M.P., Gilmour, D. F., Tomlinson, L. P., Lang, N. N., Mark, P. B. (2023) A systematic review and meta-analysis of the effect of intravitreal VEGF inhibitors on cardiorenal outcomes. Nephrology Dialysis Transplantation, 38, pp. 1666-1681. (doi: 10.1093/ndt/gfac305)

Paes, D., Schepers, M., Willems, E., Rombaut, B., Tiane, A., Solomina, Y., Tibbo, A., Blair, C., Kyurkchieva, E., Baillie, G. S., Ricciarelli, R., Brullo, C., Fedele, E., Bruno, O., van den Hove, D., Vanmierlo, T., Prickaerts, J. (2023) Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology. Cellular and Molecular Life Sciences, 80, (doi: 10.1007/s00018-023-04804-w)

Dowsett, L., Duluc, L., Higgins, E., Alghamdi, F., Fast, W., Salt, I. P., Leiper, J. (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular Signalling, 107, (doi: 10.1016/j.cellsig.2023.110676)

Patel, T. R., Villines, T., Kramer, C. M., Kwong, R. Y., Raharjo, D. E., Kunadian, V., Berry, C. (2023) Great Debate: computed tomography coronary angiography should be the initial diagnostic test in suspected angina. European Heart Journal, 44, pp. 2366-2375. (doi: 10.1093/eurheartj/ehac597)

Elyan, B. M.P., Rankin, S., Jones, R., Lang, N. N., Mark, P. B., Lees, J. S. (2023) Kidney disease patient representation in trials of combination therapy with VEGF-signaling pathway inhibitors and immune checkpoint inhibitors: a systematic review. Kidney Medicine, 5, (doi: 10.1016/j.xkme.2023.100672)

Kyurkchieva, E., Baillie, G. S. (2023) Short PDE4 isoforms as drug targets in disease. Frontiers in Bioscience: Landmark, 28, (doi: 10.31083/j.fbl2807133)

Youkee, D., Deen, G., Baldeh, M., Conteh, Z. F., Fox-Rushby, J., Gbessay, M., Johnson, J., Langhorne, P., Leather, A., Lisk, D. R., Marshall, I., O'Hara, J., Pessima, S., Rudd, A., Soley-Bori, M., Thompson, M., Wafa, H., Wang, Y., Watkins, C. L., Williams, C., Wolfe, C., Sackley, C. (2023) Stroke in Sierra Leone: case fatality rate and functional outcome after stroke in Freetown. International Journal of Stroke, 18, pp. 672-680. (doi: 10.1177/17474930231164892)

Morrow, A. J., McFarlane, R., Berry, C. (2023) Novel therapy for ischaemia with no obstructive coronary arteries. European Heart Journal, (doi: 10.1093/eurheartj/ehad391)

Habibi, J., Bosch, J., Bidulka, P., Belson, S., DePaul, V., Gandhi, D., Kumurenzi, A., Melifonwu, R., Pandian, J., Langhorne, P., Solomon, J. M., Dawar, D., Carroll, S., Urimubenshi, G., Kaddumukasa, M., Hamilton, L. (2023) Strategies for specialty training of healthcare professionals in low-resource settings: a systematic review on evidence from stroke care. BMC Medical Education, 23, (doi: 10.1186/s12909-023-04431-w)

Henriksen, P. A., Rankin, S., Lang, N. N. (2023) Cardioprotection in patients at high risk of anthracycline-induced cardiotoxicity: JACC: CardioOncology Primer. JACC: CardioOncology, 5, pp. 292-297. (doi: 10.1016/j.jaccao.2023.05.004)

Smilowitz, N. R., Toleva, O., Chieffo, A., Perera, D., Berry, C. (2023) Coronary microvascular disease in contemporary clinical practice. Circulation: Cardiovascular Interventions, 16, pp. 386-395. (doi: 10.1161/CIRCINTERVENTIONS.122.012568)

De Beer, D., Mels, C. M.C., Schutte, A. E., Delles, C., Mary, S., Mullen, W., Latosinska, A., Mischak, H., Kruger, R. (2023) Identifying a urinary peptidomics profile for hypertension in young adults: the African-PREDICT study. Proteomics, 23, (doi: 10.1002/pmic.202200444)

Rabbani, A., Gao, H., Lazarus, A., Dalton, D., Ge, Y., Mangion, K., Berry, C., Husmeier, D. (2023) Image-based estimation of the left ventricular cavity volume using deep learning and Gaussian process with cardio-mechanical applications. Computerized Medical Imaging and Graphics, 106, (doi: 10.1016/j.compmedimag.2023.102203)

Angelov, A., Connelly, P. J., Delles, C., Kararigas, G. (2023) Sex-biased and sex hormone-dependent regulation of apolipoprotein A1. Current Opinion in Physiology, 33, (doi: 10.1016/j.cophys.2023.100654)

Kumluang, S., Wu, O., Langhorne, P., Geue, C. (2023) Stroke resource utilisation and all-cause mortality in Thailand 2017–2020: a retrospective, cross-sectional study. BMJ Open, 13, (doi: 10.1136/bmjopen-2023-072259)

Sykes, R. A., Neves, K. B., Alves-Lopes, R., Caputo, I., Jamieson, N. B., Kamdar, A., Legrini, A., Leslie, H., McIntosh, A., McConnachie, A., Morrow, A., McFarlane, R. W., Mangion, K., McAbney, J., Montezano, A. C., Touyz, R. M., Wood, C., Berry, C. (2023) Vascular mechanisms of post-COVID-19 conditions: rho-kinase is a novel target for therapy. European Heart Journal: Cardiovascular Pharmacotherapy, 9, pp. 371-386. (doi: 10.1093/ehjcvp/pvad025)

Arisido, M. W., Foco, L., Shoemaker, R., Melotti, R., Delles, C., Gögele, M., Barolo, S., Baron, S., Azizi, M., Dominiczak, A. F., Zennaro, M.-C., P. Pramstaller, P., Poglitsch, M., Pattaro, C. (2023) Cluster analysis of angiotensin biomarkers to identify antihypertensive drug treatment in population studies. BMC Medical Research Methodology, 23, (doi: 10.1186/s12874-023-01930-8)

Le, N. N., Tran, T. Q. B., Du Toit, C., Gill, D., Padmanabhan, S. (2023) Establishing plausibility of cardiovascular adverse effects of immunotherapies using Mendelian randomisation. Frontiers in Cardiovascular Medicine, 10, (doi: 10.3389/fcvm.2023.1116799)

Khan, M., Wasay, M., O'Donnell, M. J., Iqbal, R., Langhorne, P., Rosengren, A., Damasceno, A., Oguz, A., Lanas, F., Pogosova, N., Alhussain, F., Oveisgharan, S., Czlonkowska, A., Ryglewicz, D., Yusuf, S. (2023) Risk factors for stroke in the young (18-45 years): a case-control analysis of INTERSTROKE data from 32 countries. Neuroepidemiology, (doi: 10.1159/000530675)

Du Toit, C. et al. (2023) Survey and evaluation of hypertension machine learning research. Journal of the American Heart Association, 12, (doi: 10.1161/JAHA.122.027896)

Wang, Y. et al. (2023) Early-life cardiovascular risk factor trajectories and vascular aging in midlife: a 30-year prospective cohort study. Hypertension, 80, pp. 1057-1066. (doi: 10.1161/HYPERTENSIONAHA.122.20518)

Girerd, N. et al. (2023) Protein biomarkers of new-onset heart failure: insights from the Heart Omics and Ageing cohort, the Atherosclerosis Risk in Communities Study, and the Framingham Heart Study. Circulation: Heart Failure, 16, pp. 426-441. (doi: 10.1161/CIRCHEARTFAILURE.122.009694)

Lees, J. S., Elyan, B. M.P., Hermann, S. M., Lang, N. N., Jones, R. J., Mark, P. B. (2023) The ‘other’ big complication: how chronic kidney disease impacts on cancer risks and outcomes. Nephrology Dialysis Transplantation, 38, pp. 1071-1079. (doi: 10.1093/ndt/gfac011)

Degenaar, A., Jacobs, A., Kruger, R., Delles, C., Mischak, H., Mels, C.M.C. (2023) Cardiovascular risk and kidney function profiling using conventional and novel biomarkers in young adults: the African-PREDICT study. BMC Nephrology, 24, (doi: 10.1186/s12882-023-03100-w)

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Chen, J. Y., Chew, K. S., Mary, S., Boder, P., Bagordo, D., Rossi, G. P., Touyz, R. M., Delles, C., Rossitto, G. (2023) Skin-specific mechanisms of body fluid regulation in hypertension. Clinical Science, 137, pp. 239-250. (doi: 10.1042/CS20220609)

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Sykes, R. et al. (2023) Rationale and design of the effect of mineralocorticoid receptor antagonist therapy in patients with acute myocardial infarction or injury and non-obstructive coronary arteries: A registry-based, stratified-medicine, randomised, controlled trial. (doi: 10.1136/heartjnl-2022-BSCMR.26)

Gulati, M., Khan, N., George, M., Berry, C., Chieffo, A., Camici, P. G., Crea, F., Kaski, J.-C., Marzilli, M., Merz, C. N. B. (2023) Ischemia with no obstructive coronary artery disease (INOCA): a patient self-report quality of life survey from INOCA international. International Journal of Cardiology, 371, pp. 28-39. (doi: 10.1016/j.ijcard.2022.09.047)

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Garimella, P. S., Du Toit, C., Le, N. N., Padmanabhan, S. (2023) A genomic deep field view of hypertension. Kidney International, 103, pp. 42-52. (doi: 10.1016/j.kint.2022.09.029)

Sykes, R. et al. (2023) Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19. Open Heart, 10, (doi: 10.1136/openhrt-2022-002192)

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Gulliver, C., Huss, S., Semjonow, A., Baillie, G. S., Hoffmann, R. (2023) The CAPRA&PDE4D5/7/9 prognostic model is significantly associated to adverse post-surgical pathology outcomes. Cancers, 15, (doi: 10.3390/cancers15010262)

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Richardson, J., Lee, M. (2023) Cardiovascular Screening Checks on Mongolian Nomads During the Khan Khentii Expedition.

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2022

Collet, C., Collison, D., Mizukami, T., McCartney, P., Sonck, J., Ford, T., Munhoz, D., Berry, C., De Bruyne, B., Oldroyd, K. (2022) Differential improvement in angina and health-related quality of life after PCI in focal and diffuse coronary artery disease. JACC: Cardiovascular Interventions, 15, pp. 2506-2518. (doi: 10.1016/j.jcin.2022.09.048)

Kumluang, S., Geue, C., Langhorne, P., Wu, O. (2022) Availability of stroke services and hospital facilities at different hospital levels in Thailand: a cross-sectional survey study. BMC Health Services Research, 22, (doi: 10.1186/s12913-022-08922-2)

Kalra, P. R., Cleland, J. G.F., Petrie, M. C., Thomson, E. A., Kalra, P. A., Squire, I. B., Ahmed, F. Z., Al-Mohammad, A., Cowburn, P. J., Foley, P. W.X., Graham, F. J., Japp, A. G., Lane, R. E., Lang, N. N., Ludman, A. J., Macdougall, I. C., Pellicori, P., Ray, R., Robertson, M., Seed, A., Ford, I. (2022) Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial. Lancet, 400, pp. 2199-2209. (doi: 10.1016/S0140-6736(22)02083-9)

McGettrick, M., Dormand, H., Brewis, M., Johnson, M. K., Lang, N. N., Church, A. C. (2022) Cardiac geometry, as assessed by cardiac magnetic resonance, can differentiate subtypes of chronic thromboembolic pulmonary vascular disease. Frontiers in Cardiovascular Medicine, 9, (doi: 10.3389/fcvm.2022.1004169)

Gerganova, G., Riddell, A., Miller, A. A. (2022) CNS border-associated macrophages in the homeostatic and ischaemic brain. Pharmacology and Therapeutics, 240, (doi: 10.1016/j.pharmthera.2022.108220)

Mark, P. B., Mangion, K., Rankin, A. J., Rutherford, E., Lang, N. N., Petrie, M. C., Stoumpos, S., Patel, R. K. (2022) Left ventricular dysfunction with preserved ejection fraction: the most common left ventricular disorder in chronic kidney disease patients. Clinical Kidney Journal, 15, pp. 2186-2199. (doi: 10.1093/ckj/sfac146)

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Bradley, C., Berry, C. (2022) Retinal microvascular function: a tractable biomarker of cardiovascular risk? Cardiovascular Research, 118, pp. 3169-3170. (doi: 10.1093/cvr/cvac170)

Kumar, A. A., Yeo, N., Whittaker, M., Attra, P., Barrick, T. R., Bridges, L. R., Dickson, D. W., Esiri, M. M., Farris, C. W., Graham, D., Lin, W. L., Meijles, D. N., Pereira, A. C., Perry, G., Rosene, D. L., Shtaya, A. B., Van Agtmael, T., Zamboni, G., Hainsworth, A. H. (2022) Vascular collagen type-IV in hypertension and cerebral small vessel disease. Stroke, 53, pp. 3696-3705. (doi: 10.1161/STROKEAHA.122.037761)

McErlane, J., McCall, P., Willder, J., Berry, C., Shelley, B. (2022) Right ventricular free wall longitudinal strain is independently associated with mortality in mechanically ventilated patients with COVID-19. Annals of Intensive Care, 12, (doi: 10.1186/s13613-022-01077-7)

Paterson, C., Hinterberg, M. A., Morrow, A. J., Sykes, R., Mangion, K., Welsh, P., McConnachie, A., Sattar, N., Berry, C., Williams, S. A. (2022) Utility of a Proteomic Surrogate for Cardiovascular Outcomes to Predict and Monitor COVID-19 Induced Myocarditis. (doi: 10.1161/circ.146.suppl_1.12132)

Yang, Y., Gao, H., Berry, C., Carrick, D., Radjenovic, A., Husmeier, D. (2022) Classification of myocardial blood flow based on dynamic contrast-enhanced magnetic resonance imaging using hierarchical Bayesian models. Journal of the Royal Statistical Society: Series C (Applied Statistics), 71, pp. 1085-1115. (doi: 10.1111/rssc.12568)

Morris, P. D., Al-Lamee, R. K., Berry, C., on behalf of the BCIS Research and Development Committee, (2022) Coronary physiological assessment in the catheter laboratory: haemodynamics, clinical assessment and future perspectives. Heart, 108, pp. 1737-1746. (doi: 10.1136/heartjnl-2020-318743)

Byrne, A., Chouliara, N., Cameron, T., Geue, C., Lewis, S., Robinson, T., Langhorne, P., Walker, M. F., Fisher, R. J. (2022) Evaluating stroke early supported discharge using cost-consequence analysis. Disability and Rehabilitation, 44, pp. 7127-7133. (doi: 10.1080/09638288.2021.1983043)

Mary, S., Boder, P., Padmanabhan, S., McBride, M. W., Graham, D., Delles, C., Dominiczak, A. F. (2022) The role of uromodulin in salt-sensitive hypertension. Hypertension, 79, pp. 2419-2429. (doi: 10.1161/HYPERTENSIONAHA.122.19888)

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Mangion, K., Berry, C. (2022) Multisystem involvement in COVID-19: what have we learnt? British Journal of Hospital Medicine, 83, pp. 1-5. (doi: 10.12968/hmed.2022.0290)

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Yang, Y., Gao, H., Berry, C., Radjenovic, A., Husmeier, D. (2022) Myocardial Perfusion Classification Using A Markov Random Field Constrained Gaussian Mixture Model. (doi: 10.11159/icsta22.146)

Lee, M. M.Y. et al. (2022) Effect of empagliflozin on kidney biochemical and imaging outcomes in patients with type 2 diabetes, or prediabetes, and heart failure with reduced ejection fraction (SUGAR-DM-HF) Circulation, 146, pp. 364-367. (doi: 10.1161/CIRCULATIONAHA.122.059851)

Acur, N., Carbajal Pina, C., Padmanabhan, S. (2022) Therme & The University of Glasgow Global Wellbeing Centre of Excellence (WellEx), Feasibility Study.

Ferreira, V. M., Berry, C. (2022) The health economics of ischemia with nonobstructive coronary arteries. JACC: Cardiovascular Imaging, 14, pp. 1380-1383. (doi: 10.1016/j.jcmg.2021.03.017)

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McCall, P.J., Willder, J.M., Stanley, B.L., Messow, C.-M., Allan, J., Gemmell, L., Puxty, A., Strachan, D., Berry, C., Shelley, B.G. (2022) Right ventricular dysfunction in patients with COVID-19 pneumonitis whose lungs are mechanically ventilated: a multicentre prospective cohort study. Anaesthesia, 77, pp. 772-784. (doi: 10.1111/anae.15745)

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Lip, S., McCallum, L., Delles, C., McClure, J. D., Guzik, T., Berry, C., Touyz, R., Padmanabhan, S. (2022) Rationale and design for the LOnger-term effects of SARS-CoV-2 INfection on blood Vessels And blood pRessure (LOCHINVAR) Open Heart, 9, (doi: 10.1136/openhrt-2022-002057)

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Lucas-Herald, A. K., Delles, C. (2022) Carotid intima-media thickness is associated with obesity and hypertension in young people. Hypertension, 79, pp. 1177-1179. (doi: 10.1161/hypertensionaha.122.19163)

Rastogi, T., Ho, F. K., Rossignol, P., Merkling, T., Butler, J., Clark, A., Collier, T., Delles, C., Jukema, J. W., Heymans, S., Latini, R., Mebazaa, A., Pellicori, P., Sever, P., Staessen, J. A., Thijs, L., Cleland, J. G., Sattar, N., Zannad, F., Girerd, N. (2022) Comparing and contrasting risk factors for heart failure in patients with and without history of myocardial infarction: data from HOMAGE and the UK Biobank. European Journal of Heart Failure, 24, pp. 976-984. (doi: 10.1002/ejhf.2495)

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Connelly, P. J., Currie, G., Delles, C. (2022) Sex differences in the prevalence, outcomes and management of hypertension. Current Hypertension Reports, 24, pp. 185-192. (doi: 10.1007/s11906-022-01183-8)

Fullerton, J. L., Thomas, J. M., Gonzalez-Trueba, L., Trivett, C., Van Kralingen, J. C., Allan, S. M., Quinn, T. J., Work, L. M. (2022) Systematic review: association between circulating microRNA expression & stroke. Journal of Cerebral Blood Flow and Metabolism, 42, pp. 935-951. (doi: 10.1177/0271678X221085090)

Crea, F., Badimon, L., Berry, C., De Caterina, R., Elliott, P. M., Hatala, R., Libby, P., Linde, C., Tybjaerg-Hansen on behalf of the EHJ Editorial Board, A. (2022) The European Heart Journal: fulfilling the mission. European Heart Journal, 43, pp. 2181-2184. (doi: 10.1093/eurheartj/ehac171)

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Stevens, K., Delles, C., Mark, P., Thomson, P., Gill, J., Gray, S., Ho, F., Rutherford, E., Lees, J. (2022) MO468: Moving more associates with reduced risk of cardiovascular disease and death across all stages of chronic kidney disease: a UK Biobank study. Nephrology Dialysis Transplantation, 37, (doi: 10.1093/ndt/gfac070.082)

O'Donnell, M. J. et al. (2022) Association of Lipids, Lipoproteins, and Apolipoproteins with Stroke Subtypes in an International Case Control Study (INTERSTROKE) Journal of Stroke, 24, pp. 224-235. (doi: 10.5853/jos.2021.02152)

Rossitto, G., Delles, C. (2022) Does excess tissue sodium storage regulate blood pressure? Current Hypertension Reports, 24, pp. 115-122. (doi: 10.1007/s11906-022-01180-x)

Beazer, J. D., Freeman, D. J. (2022) Estradiol and HDL function in women – a partnership for life. Journal of Clinical Endocrinology and Metabolism, 107, pp. e2192-2194. (doi: 10.1210/clinem/dgab811)

He, W. et al. (2022) Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size. Cardiovascular Research, 118, pp. 1535-1547. (doi: 10.1093/cvr/cvab204)

Al-Lamee, R., Aubiniere-Robb, L., Berry, C. (2022) The British Cardiovascular Society and clinical studies in ischaemic heart disease: from RITA to ORBITA, and beyond. Heart, 108, pp. 800-806. (doi: 10.1136/heartjnl-2021-320150)

Kite, T. A., Banning, A. S., Ladwiniec, A., Gale, C. P., Greenwood, J. P., Dalby, M., Hobson, R., Barber, S., Parker, E., Berry, C., Flather, M. D., Curzen, N., Banning, A. P., McCann, G. P., Gershlick, A. H. (2022) Very early invasive angiography versus standard of care in higher-risk non-ST elevation myocardial infarction: study protocol for the prospective multicentre randomised controlled RAPID N-STEMI trial. BMJ Open, 12, (doi: 10.1136/bmjopen-2021-055878)

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Berry, C., Ang, D. T.Y. (2022) Picture perfect? Performance of quantitative coronary angiography-based vessel FFR versus pressure wire-based FFR. EuroIntervention, 17, pp. 1463-1465. (doi: 10.4244/EIJ-E-22-00005)

Mileva, N., Nagumo, S., Mizukami, T., Sonck, J., Berry, C., Gallinoro, E., Monizzi, G., Candreva, A., Munhoz, D., Vassilev, D., Penicka, M., Barbato, E., De Bruyne, B., Collet, C. (2022) Prevalence of coronary microvascular disease and coronary vasospasm in patients with nonobstructive coronary artery disease: systematic review and meta‐analysis. Journal of the American Heart Association, 11, (doi: 10.1161/JAHA.121.023207)

Toloza, F. J. K. et al. (2022) Association between maternal thyroid function and risk of gestational hypertension and pre-eclampsia: a systematic review and individual-participant data meta-analysis. Lancet Diabetes and Endocrinology, 10, pp. 243-252. (doi: 10.1016/S2213-8587(22)00007-9)

Abraham, G. R., Morrow, A. J., Oliveira, J., Weir-McCall, J. R., Davenport, E. E., Berry, C., Davenport, A. P., Hoole, S. P. (2022) Mechanistic study of the effect of Endothelin SNPs in microvascular angina – Protocol of the PRIZE Endothelin Sub-Study. International Journal of Cardiology: Heart and Vasculature, 39, (doi: 10.1016/j.ijcha.2022.100980)

Tibbo, A. J., Mika, D., Dobi, S., Ling, J., McFall, A., Tejeda, G. S., Blair, C., MacLeod, R., MacQuaide, N., Gök, C., Fuller, W., Smith, B. O., Smith, G. L., Vandecasteele, G., Brand, T., Baillie, G. S. (2022) Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins. Journal of Molecular and Cellular Cardiology, 165, pp. 86-102. (doi: 10.1016/j.yjmcc.2022.01.001)

Dritsoula, A., Dowsett, L., Pilotti, C., O'Connor, M. N., Moss, S. E., Greenwood, J. (2022) Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway. Scientific Reports, 12, (doi: 10.1038/s41598-022-08516-2)

Ang, D. T.Y., Sidik, N. P., Morrow, A. J., Sykes, R., McEntegart, M. B., Berry, C. (2022) Interventional diagnostic procedure: A practical guide for the assessment of coronary vascular function. Journal of Visualized Experiments, 181, (doi: 10.3791/62265)

Shaman, J. A., Bousman, C. A., Mitropoulou, C., Padmanabhan, S. (2022) Editorial: Pharmacogenomics: from bench to bedside and back again. Frontiers in Genetics, 13, (doi: 10.3389/fgene.2022.878191)

Divorty, N., Jenkins, L., Ganguly, A., Butcher, A. J., Hudson, B. D., Schulz, S., Tobin, A. B., Nicklin, S. A., Milligan, G. (2022) Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor. Journal of Biological Chemistry, 298, (doi: 10.1016/j.jbc.2022.101655)

Ferguson, L. D., Cathcart, S., Rimmer, D., Semple, G., Brooksbank, K., Paterson, C., Brown, R., Harvie, J., Gao, X., Radjenovic, A., Welsh, P., McInnes, I. B., Sattar, N., Siebert, S. (2022) Effect of the phosphodiesterase 4 inhibitor apremilast on cardiometabolic outcomes in psoriatic disease – results of the Immune Metabolic Associations in Psoriatic Arthritis study. Rheumatology, 61, pp. 1026-1034. (doi: 10.1093/rheumatology/keab474)

Dobbin, S. J.H., Herrmann, S. M.S., Lang, N. N., Herrmann, J., Touyz, R. M. (2022) Hypertension and renal disease before anti-cancer therapies. Elsevier

Herrmann, S. M.S., Dobbin, S. J.H., Herrmann, J., Touyz, R. M., Lang, N. N. (2022) Hypertension and renal disease during anti-cancer therapies. Elsevier

Lang, N. N., Dobbin, S. J.H., Herrmann, S. M.S., Herrmann, J., Touyz, R. M. (2022) Hypertension and renal failure prevention and management after cancer therapy. Elsevier

Glen, C., Tan, Y. Y., Waterston, A., Evans, T. R. J., Jones, R. J., Petrie, M. C., Lang, N. N. (2022) Mechanistic and clinical overview cardiovascular toxicity of BRAF and MEK inhibitors: JACC: CardioOncology state-of-the-art review. JACC: CardioOncology, 4, pp. 1-18. (doi: 10.1016/j.jaccao.2022.01.096)

Martin, T. P., MacDonald, E. A., Elbassioni, A. A., Zaeri, A. A. I., O'Toole, D., Nicklin, S. A., Gray, G. A., Loughrey, C. M. (2022) Pre-clinical models of myocardial infarction: from mechanism to translation. British Journal of Pharmacology, 179, pp. 770-791. (doi: 10.1111/bph.15595)

Stoyek, M. R., MacDonald, E., Mantifel, M., Baillie, J. S., Selig, B. M., Croll, R. P., Smith, F. M., Quinn, T. A. (2022) Drivers of sinoatrial node automaticity in zebrafish: comparison with mechanisms of mammalian pacemaker function. Frontiers in Physiology, 13, (doi: 10.3389/fphys.2022.818122)

Reynolds, H. R., Bairey Merz, C. N., Berry, C., Samuel, R., Saw, J., Smilowitz, N. R., de Souza, A. C. d. A.H., Sykes, R., Taqueti, V. R., Wei, J. (2022) Coronary arterial function and disease in women with no obstructive coronary arteries. Circulation Research, 130, pp. 529-551. (doi: 10.1161/CIRCRESAHA.121.319892)

Alexander, J., Dawson, J., Langhorne, P. (2022) Dynamic hand orthoses for the recovery of hand and arm function in adults after stroke: a systematic review and meta-analysis of randomised controlled trials. Topics in Stroke Rehabilitation, 29, pp. 114-124. (doi: 10.1080/10749357.2021.1878669)

Nogal, A., Louca, P., Tran, T. Q. B., Bowyer, R. C., Christofidou, P., Steves, C. J., Berry, S. E., Wong, K., Wolf, J., Franks, P. W., Mangino, M., Spector, T. D., Valdes, A. M., Padmanabhan, S., Menni, C. (2022) Incremental value of a panel of serum metabolites for predicting risk of atherosclerotic cardiovascular disease. Journal of the American Heart Association, 11, (doi: 10.1161/JAHA.121.024590)

Chong, M. R., Narula, S., Morton, R., Judge, C., Akhabir, L., Cawte, N., Pathan, N., Lali, R., Mohammadi-Shemirani, P., Shoamanesh, A., O'Donnell, M., Yusuf, S., Langhorne, P., Pare, G. (2022) Mitochondrial DNA copy number as a marker and mediator of stroke prognosis: observational and Mendelian randomization analyses. Neurology, 98, pp. e470-e482. (doi: 10.1212/WNL.0000000000013165)

Mujaj, B., ZHang, Z.-Y., Yang, W.-Y., Thijs, L., Wei, F.-F., Verhamme, P., Delles, C., Butler, J., Sever, P., Latini, R., Cleland, J. G. F., Zannad, F., Staessen, J. A. (2022) Aspirin use is associated with increased risk for incident heart failure: a patient-level pooled analysis. ESC Heart Failure, 9, pp. 685-694. (doi: 10.1002/ehf2.13688)

Connelly, P. J., Casey, H., Montezano, A. C., Touyz, R. M., Delles, C. (2022) Sex steroids receptors, hypertension and vascular ageing. Journal of Human Hypertension, 36, pp. 120-125. (doi: 10.1038/s41371-021-00576-7)

Ciminata, G., Geue, C., Wu, O., Deidda, M., Kreif, N., Langhorne, P. (2022) Propensity score methods for comparative-effectiveness analysis: a case study of direct oral anticoagulants in the atrial fibrillation population. PLoS ONE, 17, (doi: 10.1371/journal.pone.0262293)

Herrmann, J. et al. (2022) Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement. European Heart Journal, 43, pp. 280-299. (doi: 10.1093/eurheartj/ehab674)

Smyth, A., O’Donnell, M., Hankey, G. J., Rangarajan, S., Lopez-Jaramillo, P., Xavier, D., Zhang, H., Canavan, M., Damasceno, A., Langhorne, P., Avezum, A., Pogosova, N., Oguz, A., Yusuf, S. (2022) Anger or emotional upset and heavy physical exertion as triggers of stroke: the INTERSTROKE study. European Heart Journal, 43, pp. 202-209. (doi: 10.1093/eurheartj/ehab738)

Delles, C. (2022) Maternally inherited essential hypertension: adding further complexity to an already complex condition. American Journal of Hypertension, 35, pp. 16-18. (doi: 10.1093/ajh/hpab133)

Moudio, S., Willis, A., Pytka, K., Abulkassim, R., Brett, R. R., Webster, J. F., Wozny, C., Barbour, M., Jiang, H.-R., Watson, D. G., van Kralingen, J. C., MacKenzie, S. M., Daniels, M., McColl, B. W., Sossick, S., Nuthall, H. N., Bushell, T. J. (2022) Protease-activated receptor 2 activation induces behavioural changes associated with depression-like behaviour through microglial-independent modulation of inflammatory cytokines. Psychopharmacology, 239, pp. 229-242. (doi: 10.1007/s00213-021-06040-1)

Baillie, G., Kyurkchieva, E., Sin, Y. Y., Ahmed, F., Rajapakse, N., Schoolmeesters, A., Richard, N., Erdman, P., Hecht, D., Chourasia, A. H., Mercurio, F., Fung, L., Chan, K., Stirling, D. (2022) Evaluating the Utility of Bi-functional Degrader Molecules for Selective Inhibition of PDE4 In Acrodysostosis Type2.

Dekkers, R., Carey, L., Langhorne, P. (2022) Making Literature Reviews Work: A Multidisciplinary Guide to Systematic Approaches. Springer

Delles, C., Rossitto, G. (2022) Of snails, earthworms, and men: insights into strategies to preserve water. Function, 3, (doi: 10.1093/function/zqab071)

Morrow, A., Gray, S. R., Bayes, H. K., Sykes, R., McGarry, E., Anderson, D., Boiskin, D., Burke, C., Cleland, J. G. F., Goodyear, C., Ibbotson, T., Lang, C. C., McConnachie, A., Mair, F., Mangion, K., Patel, M., Sattar, N., Taggart, D., Taylor, R., Dawkes, S., Berry, C. (2022) Prevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise—CISCO-21. Trials, 23, (doi: 10.1186/s13063-022-06632-y)

Quinn, T. J., Taylor-Rowan, M., Elliott, E., Drozdowska, B., McMahon, D., Broomfield, N. M., Barber, M., MacLeod, M. J., Cvoro, V., Byrne, A., Ross, S., Crow, J., Slade, P., Dawson, J., Langhorne, P. (2022) Research protocol – Assessing Post-Stroke Psychology Longitudinal Evaluation (APPLE) study: a prospective cohort study in stroke. Cerebral Circulation - Cognition and Behavior, 3, (doi: 10.1016/j.cccb.2022.100042)

Armignacco, R. et al. (2022) Whole blood methylome-derived features to discriminate endocrine hypertension. Clinical Epigenetics, 14, (doi: 10.1186/s13148-022-01347-y)

2021

Connelly, P. J., Delles, C. (2021) Cardiovascular disease in transgender people: recent research and emerging evidence. Cardiovascular Research, 117, pp. e174-e176. (doi: 10.1093/cvr/cvab288)

Collison, D., Didagelos, M., Aetesam-Ur-Rahman, M., Copt, S., McDade, R., McCartney, P., Ford, T. J., McClure, J., Lindsay, M., Shaukat, A., Rocchiccioli, P., Brogan, R., Watkins, S., McEntegart, M., Good, R., Robertson, K., O’Boyle, P., Davie, A., Khan, A., Hood, S., Eteiba, H., Berry, C., Oldroyd, K. G. (2021) Post-stenting fractional flow reserve vs coronary angiography for optimization of percutaneous coronary intervention (TARGET-FFR) European Heart Journal, 42, pp. 4656-4668. (doi: 10.1093/eurheartj/ehab449)

Trivett, C., Lees, Z. J., Freeman, D. J. (2021) Adipose tissue function in healthy pregnancy, gestational diabetes mellitus and pre-eclampsia. European Journal of Clinical Nutrition, 75, pp. 1745-1756. (doi: 10.1038/s41430-021-00948-9)

Lang, N. N., Touyz, R. M. (2021) Mechanistic science in cardiovascular-oncology: the way forward to maximise anti-cancer drug effects and minimise cardiovascular toxicity. Clinical Science, 135, pp. 2661-2663. (doi: 10.1042/CS20210986)

Keenan, N. G., Captur, G., McCann, G. P., Berry, C., Myerson, S. G., Fairbairn, T., Hudsmith, L., O'Regan, D. P., Westwood, M., Greenwood, J. P. (2021) Regional variation in cardiovascular magnetic resonance service delivery across the UK. Heart, 107, pp. 1974-1979. (doi: 10.1136/heartjnl-2020-318667)

Mary, S., Boder, P., Rossitto, G., Graham, L., Scott, K., Flynn, A., Kipgen, D., Graham, D., Delles, C. (2021) Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats. Clinical Science, 135, pp. 2749-2761. (doi: 10.1042/CS20211017)

Mahindra, A., Tejeda, G., Rossi, M., Janha, O., Herbert, I., Morris, C., Morgan, D. C., Beattie, W., Montezano, A. C., Hudson, B., Tobin, A. B., Bhella, D., Touyz, R. M., Jamieson, A. G., Baillie, G. S., Blair, C. M. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16, (doi: 10.1371/journal.pone.0260283)

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Fisher, R. J., Byrne, A., Chouliara, N., Lewis, S., Paley, L., Hoffman, A., Rudd, A., Robinson, T., Langhorne, P., Walker, M. (2021) Effect of stroke early supported discharge on length of hospital stay: analysis from a national stroke registry. BMJ Open, 11, (doi: 10.1136/bmjopen-2020-043480)

McCallum, L., Brooksbank, K., McConnachie, A., Aman, A., Lip, S., Dawson, J., MacIntyre, I. M., MacDonald, T. M., Webb, D. J., Padmanabhan, S. (2021) Rationale and design of the genotype-blinded trial of torasemide for the treatment of hypertension (BHF UMOD) American Journal of Hypertension, 34, pp. 92-99. (doi: 10.1093/ajh/hpaa166)

Willder, J. M., McCall, P., Messow, C.-M., Gillies, M., Berry, C., Shelley, B. (2021) Study protocol for COVID-RV: a multicentre prospective observational cohort study of right ventricular dysfunction in ventilated patients with COVID-19. BMJ Open, 11, (doi: 10.1136/bmjopen-2020-042098)

Jacobs, M., Benovoy, M., Chang, L.-C., Corcoran, D., Berry, C., Arai, A. E., Hsu, L.-Y. (2021) Automated segmental analysis of fully quantitative myocardial blood flow maps by first-pass perfusion cardiovascular magnetic resonance. IEEE Access, 9, pp. 52796-52811. (doi: 10.1109/ACCESS.2021.3070320)

Kamdar, A., Sykes, R., Morrow, A., Mangion, K., Berry, C. (2021) Cardiovascular outcomes of glucose lowering therapy in chronic kidney disease patients: a systematic review with meta-analysis. Reviews in Cardiovascular Medicine, 22, pp. 1479-1490. (doi: 10.31083/j.rcm2204152)

Small, H. Y., Delles, C. (2021) Letter to the Editor regarding Cunningham et al. 2020. Hypertension in Pregnancy, 40, pp. 133. (doi: 10.1080/10641955.2021.1899201)

McGettrick, M., MacLellan, A., McCaughey, P., Bagot, C., Brewis, M.J., Lang, N.N., Johnson, M.K., Church, A.C. (2021) Pulmonary thromboembolism in hospitalised patients with COVID-19: a retrospective national study of patients managed in critical care and ward environments in Scotland. BMJ Open, 11, (doi: 10.1136/bmjopen-2021-050281)

Sykes, R., Briscoe, M., Krystofiak, T., Peck, O., Mangion, K., Berry, C. (2021) Type 2 myocardial infarction and myocardial injury: eligibility for novel medical therapy to de-risk clinical trials. Open Heart, 8, (doi: 10.1136/openhrt-2021-001633)

Ang, D. T. Y., Berry, C. (2021) What an interventionalist needs to know about INOCA. Interventional Cardiology Review, 16, (doi: 10.15420/icr.2021.16)

Sykes, R., Doherty, D., Mangion, K., Morrow, A., Berry, C. (2021) What an interventionalist needs to know about MI with non-obstructive coronary arteries. Interventional Cardiology Review, 16, (doi: 10.15420/icr.2021.10)

2020

Rossitto, G., Mary, S., McAllister, C., Neves, K. B., Haddow, L., Rocchiccioli, J. P., Lang, N. N., Murphy, C. L., Touyz, R. M., Petrie, M. C., Delles, C. (2020) Reduced lymphatic reserve in heart failure with preserved ejection fraction. Journal of the American College of Cardiology, 76, pp. 2817-2829. (doi: 10.1016/j.jacc.2020.10.022)

Mangion, K. et al. (2020) The Chief Scientist Office cardiovascular and pulmonary imaging in SARS Coronavirus disease-19 (CISCO-19) study. Cardiovascular Research, 116, pp. 2185-2196. (doi: 10.1093/cvr/cvaa209)

Surendran, P. et al. (2020) Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics, 52, pp. 1314-1332. (doi: 10.1038/s41588-020-00713-x)

Mangion, K., Loughrey, C., Auger, D. A., McComb, C., Lee, M. M., Corcoran, D., McEntegart, M., Davie, A., Good, R., Lindsay, M., Eteiba, H., Rocchiccioli, J. P., Watkins, S., Hood, S., Shaukat, A., Haig, C., Epstein, F. H., Berry, C. (2020) Displacement encoding with stimulated echoes enables the identification of infarct transmurality early postmyocardial infarction. Journal of Magnetic Resonance Imaging, 52, pp. 1722-1731. (doi: 10.1002/jmri.27295)

Zamai, N., Cortie, C. H., Jarvie, E. M., Onyiaodike, C. C., Alrehaili, A., Francois, M., Freeman, D. J., Meyer, B. J. (2020) In pregnancy, maternal HDL is specifically enriched in, and carries the highest proportion of, DHA in plasma. Prostaglandins, Leukotrienes and Essential Fatty Acids, 163, (doi: 10.1016/j.plefa.2020.102209)

Main, A., Fuller, W., Baillie, G. S. (2020) Post-translational regulation of cardiac myosin binding protein-C: a graphical review. Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109788)

O'Toole, D., Zaeri, A. A. I., Nicklin, S. A., French, A. T., Loughrey, C. M., Martin, T. P. (2020) Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling. Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109770)

McFall, A., Nicklin, S. A., Work, L. M. (2020) The counter regulatory axis of the renin angiotensin system in the brain and ischaemic stroke: insight from preclinical stroke studies and therapeutic potential. Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109809)

Pashova, A., Work, L.M., Nicklin, S.A. (2020) The role of extracellular vesicles in neointima formation post vascular injury. Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109783)

Beazer, J. D., Patanapirunhakit, P., Gill, J. M.R., Graham, D., Karlsson, H., Ljunggren, S., Mulder, M., Freeman, D. J. (2020) High-density lipoprotein’s vascular protective functions in metabolic and cardiovascular disease - could extracellular vesicles be at play? Clinical Science, 134, pp. 2977-2986. (doi: 10.1042/CS20200892)

Ho, F. K., Celis-Morales, C. A., Gray, S. R., Katikireddi, S. V., Niedzwiedz, C. L., Hastie, C., Ferguson, L. D., Berry, C., Mackay, D. F., Gill, J. M.R., Pell, J. P., Sattar, N., Welsh, P. (2020) Modifiable and non-modifiable risk factors for COVID-19, and comparison to risk factors for influenza and pneumonia: results from a UK Biobank prospective cohort study. BMJ Open, 10, (doi: 10.1136/bmjopen-2020-040402)

Briscoe, M., Sykes, R. A., Krysztofiak, T., Peck, O. H., Mangion, K., Berry, C. (2020) Clinical Significance of Coronavirus Disease 2019 in Hospitalized Patients With Myocardial Injury. (doi: 10.1161/circ.142.suppl_3.15932)

Briscoe, M., Sykes, R. A., Krysztofiak, T., Mangion, K., Peck, O. H., Berry, C. (2020) Clinical Significance of Troponin Elevation in a Contemporary Hospitalized Population: Endotypes, Morbidity and In-hospital Mortality. (doi: 10.1161/circ.142.suppl_3.14870)

Charla, E., Mercer, J., Maffia, P., Nicklin, S. (2020) Extracellular vesicle signalling in atherosclerosis. Cellular Signalling, 75, (doi: 10.1016/j.cellsig.2020.109751)

McCartney, P. J. et al. (2020) Low-dose intracoronary alteplase during primary percutaneous coronary intervention in patients with acute myocardial infarction: the T-TIME three-arm RCT. Efficacy and Mechanism Evaluation, 7, (doi: 10.3310/eme07050)

Morrow, A. J. et al. (2020) Rationale and design of the Medical Research Council precision medicine with Zibotentan in microvascular angina (PRIZE) trial. American Heart Journal, 229, pp. 70-80. (doi: 10.1016/j.ahj.2020.07.007)

Langhorne, P., Audebert, H. J., Cadilhac, D. A., Kim, J., Lindsay, P. (2020) Stroke systems of care in high-income countries: what is optimal? Lancet, 396, pp. 1433-1442. (doi: 10.1016/S0140-6736(20)31363-5)

Kunadian, V., Chieffo, A., Camici, P. G., Berry, C., Escaned, J., Maas, A. H. E. M., Prescott, E., Karam, N., Appelman, Y., Fraccaro, C., Louise Buchanan, G., Manzo-Silberman, S., Al-Lamee, R., Regar, E., Lansky, A., Abbott, J. D., Badimon, L., Duncker, D. J., Mehran, R., Capodanno, D., Baumbach, A. (2020) An EAPCI expert consensus document on ischaemia with non-obstructive coronary arteries in collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation endorsed by Coronary Vasomotor Disorders International Study Group. European Heart Journal, 41, pp. 3504-3520. (doi: 10.1093/eurheartj/ehaa503)

Lang, N. N., Dobbin, S. J.H., Petrie, M. C. (2020) Vericiguat in worsening heart failure – agonising over, or celebrating, agonism. Cardiovascular Research, 116, pp. e152-e155. (doi: 10.1093/cvr/cvaa247)

Dowsett, L., Higgins, E., Alanazi, S., Alshuwayer, N. A., Leiper, F. C., Leiper, J. (2020) ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis. Journal of Clinical Medicine, 9, (doi: 10.3390/jcm9093026)

Ford, T. J., Corcoran, D., Padmanabhan, S., Aman, A., Rocchiccioli, P., Good, R., McEntegart, M., Maguire, J. J., Watkins, S., Eteiba, H., Shaukat, A., Lindsay, M., Robertson, K., Hood, S., McGeoch, R., McDade, R., Yii, E., Sattar, N., Hsu, L.-Y., Arai, A. E., Oldroyd, K. G., Touyz, R. M., Davenport, A. P., Berry, C. (2020) Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction. European Heart Journal, 41, pp. 3239-3252. (doi: 10.1093/eurheartj/ehz915)

Sattar, N., Ho, F. K., Gill, J. M.R., Ghouri, N., Gray, S. R., Celis-Morales, C. A., Katikireddi, S. V., Berry, C., Pell, J. P., McMurray, J. J.V., Welsh, P. (2020) BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: preliminary findings from UK biobank. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 14, pp. 1149-1151. (doi: 10.1016/j.dsx.2020.06.060)

Cameron, A. C., McMahon, K., Hall, M., Neves, K. B., Rios, F. J., Montezano, A. C., Welsh, P., Waterston, A., White, J., Mark, P. B., Touyz, R. M., Lang, N. N. (2020) Comprehensive characterisation of the vascular effects of cisplatin-based chemotherapy in patients with testicular cancer. JACC: CardioOncology, 2, pp. 443-455. (doi: 10.1016/j.jaccao.2020.06.004)

Ford, T. J., Ong, P., Sechtem, U., Beltrame, J., Camici, P. G., Crea, F., Kaski, J.-C., Bairey Merz, C. N., Pepine, C. J., Shimokawa, H., Berry, C. (2020) Assessment of vascular dysfunction in patients without obstructive coronary artery disease: why, how and when. JACC: Cardiovascular Interventions, 13, pp. 1847-1864. (doi: 10.1016/j.jcin.2020.05.052)

Rossitto, G., Mary, S., Chen, J. Y., Bodder, P., Chew, K. S., Neves, K. B., Alves, R. L., Montezano, A. C., Welsh, P., Petrie, M. C., Graham, D., Touyz, R. M., Delles, C. (2020) Tissue sodium excess is not hypertonic and reflects extracellular volume expansion. Nature Communications, 11, (doi: 10.1038/s41467-020-17820-2)

McClure, J. D., Ramsay, J. C., Berry, C. (2020) Pooled analysis of bleeding and major adverse cardiovascular events in clinical trials of time-constrained dual-antiplatelet therapy after percutaneous coronary intervention. Journal of the American Heart Association, 9, (doi: 10.1161/JAHA.120.017109)

Guzik, T. J., Mohiddin, S. A., Dimarco, A., Patel, V., Savvatis, K., Marelli-Berg, F. M., Madhur, M. S., Tomaszewksi, M., Maffia, P., D'Acquisto, F., Nicklin, S. A., Marian, A. J., Nosalski, R., Murray, E. C., Guzik, B., Berry, C., Touyz, R. M., Kreutz, R., Wang, D. W., Bhella, D., Sagliocco, O., Crea, F., Thomson, E. C., McInnes, I. B. (2020) COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Cardiovascular Research, 116, pp. 1666-1687. (doi: 10.1093/cvr/cvaa106)

Fisher, R. J., Byrne, A., Chouliara, N., Lewis, S., Paley, L., Hoffman, A., Rudd, A., Robinson, T., Langhorne, P., Walker, M. F. (2020) Effectiveness of stroke early supported discharge. Circulation: Cardiovascular Quality and Outcomes, 13, (doi: 10.1161/circoutcomes.119.006395)

Zou, Z.-G., Rios, F. J., Neves, K. B., Alves-Lopes, R., Ling, J., Baillie, G. S., Gao, X., Fuller, W., Camargo, L. L., Gudermann, T., Chubanov, V., Montezano, A. C., Touyz, R. M. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. Clinical Science, 134, pp. 2019-2035. (doi: 10.1042/CS20200827)

Connelly, P. J., Jandeleit-Dahm, K. A.M., Delles, C. (2020) Sex and gender aspects in vascular pathophysiology. Clinical Science, 134, pp. 2203-2207. (doi: 10.1042/CS20200876)

Campbell, R. T., Jasilek, A., Mischak, H., Nkuipou-Kenfack, E., Latosinska, A., Welsh, P. I., Jackson, C. E., Cannon, J., McConnachie, A., Delles, C., McMurray, J. J.V. (2020) The novel urinary proteomic classifier HF1 has similar diagnostic and prognostic utility to BNP in heart failure. ESC Heart Failure, 7, pp. 1595-1604. (doi: 10.1002/ehf2.12708)

Demin, A., Løge, B., Zhiteneva, O., Nishida, C., Whiting, S., Rippin, H., Delles, C., Karymbaeva, S., Wickramasinghe, K., Breda, J. (2020) Trans fatty acid elimination policy in member states of the Eurasian Economic Union: implementation challenges and capacity for enforcement. Journal of Clinical Hypertension, 22, pp. 1328-1337. (doi: 10.1111/jch.13945)

Tarar, O. M., Ahmed, K. M., Nishtar, N. A., Achakzai, A. B. K., Gulzar, Y., Delles, C., Al-Jawaldeh, A. (2020) Understanding the complexities of prevalence of trans fat and its control in food supply in Pakistan. Journal of Clinical Hypertension, 22, pp. 1338-1346. (doi: 10.1111/jch.13943)

Dobbie, L. J., Mackin, S. T., Hogarth, K., Lonergan, F., Kannenkeril, D., Brooksbank, K., Delles, C. (2020) Validation of semi-automated flow mediated dilation measurement in healthy volunteers. Blood Pressure Monitoring, 25, pp. 216-223. (doi: 10.1097/MBP.0000000000000448)

MacDonald, E. A., Madl, J., Greiner, J., Ramadan, A. F., Wells, S. M., Torrente, A. G., Kohl, P., Rog-Zielinska, E. A., Quinn, T. A. (2020) Sinoatrial node structure, mechanics, electrophysiology and the chronotropic response to stretch in rabbit and mouse. Frontiers in Physiology, 11, (doi: 10.3389/fphys.2020.00809)

Fong, L. C. W., Ford, T. J., da Costa, B. R., Jüni, P., Berry, C. (2020) Bias and loss to follow-up in cardiovascular randomized trials: a systematic review. Journal of the American Heart Association, 9, (doi: 10.1161/JAHA.119.015361)

Bulluck, H., Carberry, J., Carrick, D., McEntegart, M., Petrie, M. C., Eteiba, H., Hood, S., Watkins, S., Lindsay, M., Mahrous, A., Ford, I., Oldroyd, K. G., Berry, C. (2020) Redefining adverse and reverse left ventricular remodeling by cardiovascular magnetic resonance following ST-segment elevation myocardial infarction and their implications on long-term prognosis. Circulation: Cardiovascular Imaging, 13, (doi: 10.1161/CIRCIMAGING.119.009937)

Louca, P., Mompeo, O., Leeming, E. R., Berry, S. E., Mangino, M., Spector, T. D., Padmanabhan, S., Menni, C. (2020) Dietary influence on systolic and diastolic blood pressure in the TwinsUK cohort. Nutrients, 12, (doi: 10.3390/nu12072130)

Drozdowska, B. A., Elliott, E., Taylor-Rowan, M., Shaw, R. C., Cuthbertson, G., Langhorne, P., Quinn, T. J. (2020) Cardiovascular risk factors indirectly affect acute post-stroke cognition through stroke severity and prior cognitive impairment: A moderated mediation analysis. Alzheimer's Research and Therapy, 12, (doi: 10.1186/s13195-020-00653-y)

Lees, J. S., Mangion, K., Rutherford, E., Witham, M. D., Woodward, R., Roditi, G., Hopkins, T., Brooksbank, K., Jardine, A., Mark, P. B. (2020) Vitamin K for kidney transplant organ recipients: investigating vEssel stiffness (ViKTORIES): study rationale and protocol of a randomised controlled trial. Open Heart, 7, (doi: 10.1136/openhrt-2019-001070)

Dobbin, S. J.H., Mangion, K., Berry, C., Roditi, G., Basak, S., Sourbron, S., White, J., Venugopal, B., Touyz, R. M., Jones, R. J., Petrie, M. C., Lang, N. N. (2020) Cardiotoxicity and myocardial hypoperfusion associated with anti-VEGF therapies: prospective cardiac magnetic resonance imaging in patients with cancer. European Journal of Heart Failure, 22, pp. 1276-1277. (doi: 10.1002/ejhf.1847)

Currie, G., Mary, S., Delles, C. (2020) Is there a role for proteomics in diabetic renal disease? NDT Plus, 35, pp. 1133-1135. (doi: 10.1093/ndt/gfz017)

Riddell, A., McBride, M., Braun, T., Nicklin, S. A., Cameron, E., Loughrey, C. M., Martin, T. P. (2020) RUNX1: an emerging therapeutic target for cardiovascular disease. Cardiovascular Research, 116, pp. 1410-1423. (doi: 10.1093/cvr/cvaa034)

Williams, J. J.L., Baillie, G. S., Palmer, T. M. (2020) Investigation of Novel Cavin-1/Suppressor of Cytokine Signaling 3 (SOCS3) Interactions by Coimmunoprecipitation, Peptide Pull-Down, and Peptide Array Overlay Approaches. Springer

Al-Hussaini, A., Abdelaty, A. M.S.E.K., Gulsin, G. S., Arnold, J. R., Garcia-Guimaraes, M., Premawardhana, D., Budgeon, C., Wood, A., Natarajan, N., Mangion, K., Rakhit, R., Hoole, S. P., Johnson, T. W., Berry, C., Hudson, I., Gershlick, A. H., Ladwiniec, A., Kovac, J., Squire, I., Samani, N. J., Plein, S., McCann, G. P., Adlam, D. (2020) Chronic infarct size after spontaneous coronary artery dissection: implications for pathophysiology and clinical management. European Heart Journal, 41, pp. 2197-2205. (doi: 10.1093/eurheartj/ehz895)

Gök, C., Plain, F., Robertson, A., Howie, J., Baillie, G. S., Fraser, N. J., Fuller, W. (2020) Dynamic palmitoylation of the sodium-calcium exchanger modulates its structure, affinity for lipid ordered domains, and inhibition by XIP. Cell Reports, 31, (doi: 10.1016/j.celrep.2020.107697)

Derakhshan, A. et al. (2020) Association of maternal thyroid function with birth weight: a systematic review and individual-participant data meta-analysis. Lancet Diabetes and Endocrinology, 8, pp. 501-510. (doi: 10.1016/S2213-8587(20)30061-9)

Sidik, N., McDermott, M., McEntegart, M. B., Berry, C. (2020) Chest pain without obstructive coronary artery disease: a case series report. European Heart Journal: Case Reports, 4, pp. 1-6. (doi: 10.1093/ehjcr/ytaa060)

Walters, R., Collier, J. M., Braighi Carvalho, L., Langhorne, P., Katijjahbe, M. A., Tan, D., Moodie, M., Bernhardt, J. (2020) Exploring post acute rehabilitation service use and outcomes for working age stroke survivors (≤65 years) in Australia, UK and South East Asia: data from the international AVERT trial. BMJ Open, 10, (doi: 10.1136/bmjopen-2019-035850)

Picone, D. S., Deshpande, R. A., Schultz, M. G., Fonseca, R., Campbell, N. R.C., Delles, C., Hecht-Olsen, M., Schutte, A. E., Stergiou, G., Padwal, R., Zhang, X.-H., Sharman, J. E. (2020) Nonvalidated home blood pressure devices dominate the online marketplace in Australia: major implications for cardiovascular risk management. Hypertension, 75, pp. 1593-1599. (doi: 10.1161/hypertensionaha.120.14719)

Ntalla, I. et al. (2020) Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nature Communications, 11, (doi: 10.1038/s41467-020-15706-x)

Lip, S., Padmanabhan, S. (2020) Genomics of blood pressure and hypertension: extending the mosaic theory toward stratification. Canadian Journal of Cardiology, 36, pp. 694-705. (doi: 10.1016/j.cjca.2020.03.001)

Delles, C., Olfert, M. (2020) Electronic cigarettes: how bad are they for your health? Cardiovascular Research, 116, pp. e64-e66. (doi: 10.1093/cvr/cvaa041)

Collison, D., McClure, J. D., Berry, C., Oldroyd, K. G. (2020) A randomized controlled trial of a physiology‐guided percutaneous coronary intervention optimization strategy: rationale and design of the TARGET FFR study. Clinical Cardiology, 43, pp. 414-422. (doi: 10.1002/clc.23342)

Maznyczka, A. M., Oldroyd, K. G., Greenwood, J. P., McCartney, P. J., Cotton, J., Lindsay, M., McEntegart, M., Rocchiccioli, J. P., Good, R., Robertson, K., Eteiba, H., Watkins, S., Shaukat, A., Petrie, C. J., Murphy, A., Petrie, M. C., Berry, C. (2020) Comparative significance of invasive measures of microvascular injury in acute myocardial infarction. Circulation: Cardiovascular Interventions, 13, (doi: 10.1161/CIRCINTERVENTIONS.119.008505)

Tzolos, E., Adamson, P.D., Hall, P.S., MacPherson, I.R., Oikonomidou, O., MacLean, M., Lewis, S.C., McVicars, H., Newby, D.E., Mills, N.L., Lang, N.N., Henriksen, P.A. (2020) Dynamic changes in high-sensitivity cardiac troponin I in response to anthracycline-based chemotherapy. Clinical Oncology, 32, pp. 292-297. (doi: 10.1016/j.clon.2019.11.008)

Hennigan, B., Berry, C., Collison, D., Corcoran, D., Eteiba, H., Good, R., McEntegart, M., Watkins, S., McClure, J., Mangion, K., Ford, T., Petrie, M. C., Hood, S., Rocchiccioli, P., Shaukat, A., Lindsay, M., Oldroyd, K. G. (2020) Percutaneous coronary intervention versus medical therapy in patients with angina and grey-zone fractional flow reserve values: a randomised clinical trial. Heart, 106, pp. 714-715. (doi: 10.1136/heartjnl-2019-316075)

Li, W., Lazarus, A., Gao, H., Martinez De Azcona Naharro, A., Fontana, M., Hawkins, P., Biswas, S., Janiczek, R., Cox, J., Berry, C., Husmeier, D., Luo, X. (2020) Analysis of cardiac amyloidosis progression using model-based markers. Frontiers in Physiology, 11, (doi: 10.3389/fphys.2020.00324)

Yang, Y., Delalio, L. J., Best, A. K., Macal, E., Milstein, J., Donnelly, I., Miller, A. M., McBride, M., Shu, X., Koval, M., Isakson, B. E., Johnstone, S. R. (2020) Endothelial pannexin 1 channels control inflammation by regulating intracellular calcium. Journal of Immunology, 204, pp. 2995-3007. (doi: 10.4049/jimmunol.1901089)

Ling, J., Blair, C. M., Baillie, G. S. (2020) Fibrin Breakdown Assay. Bio-Protocol, 10, (doi: 10.21769/BioProtoc.3585)

Nosalski, R., Siedlinski, M., Denby, L., Mcginnigle, E., Nowak, M., Nguyen Dinh Cat, A., Medina-Ruiz, L., Cantini, M., Skiba, D., Wilk, G., Osmenda, G., Rodor, J., Salmeron-Sanchez, M., Graham, G., Maffia, P., Graham, D., Baker, A. H., Guzik, T. J. (2020) T cell-derived miRNA-214 mediates perivascular fibrosis in hypertension. Circulation Research, 126, pp. 988-1003. (doi: 10.1161/CIRCRESAHA.119.315428)

Blair, C. M., Ling, J., Baillie, G. S. (2020) Measuring cAMP specific phosphodiesterase activity: a two-step radioassay. Bio-Protocol, 10, (doi: 10.21769/BioProtoc.3581)

Delles, C., Li, H., Touyz, R. M. (2020) ACE2 the Janus-faced protein – from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19. Clinical Science, 134, pp. 747-750. (doi: 10.1042/CS20200363)

Tofte, N. et al. (2020) Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective observational study and embedded randomised placebo-controlled trial. Lancet Diabetes and Endocrinology, 8, pp. 301-312. (doi: 10.1016/S2213-8587(20)30026-7)

Frazier, S., McBride, M. W., Mulvana, H., Graham, D. (2020) From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia. Clinical Science, 134, pp. 1001-1025. (doi: 10.1042/CS20200023)

Wigmore, E. M., Hafferty, J. D., Hall, L. S., Howard, D. M., Clarke, T.-K., Fabbri, C., Lewis, C. M., Uher, R., Navrady, L. B., Adams, M. J., Zeng, Y., Campbell, A., Gibson, J., Thomson, P. A., Hayward, C., Smith, B. H., Hocking, L. J., Padmanabhan, S., Deary, I. J., Porteous, D. J., Mors, O., Mattheisen, M., Nicodemus, K. K., McIntosh, A. M. (2020) Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP. Pharmacogenomics Journal, 20, pp. 329-341. (doi: 10.1038/s41397-019-0067-3)

Jackson, A. M., Zhang, R., Findlay, I., Robertson, K., Lindsay, M., Morris, T., Forbes, B., Papworth, R., McConnachie, A., Mangion, K., Jhund, P. S., McCowan, C., Berry, C. (2020) Healthcare disparities for women hospitalised with myocardial infarction and angina. European Heart Journal: Quality of Care and Clinical Outcomes, 6, pp. 156-165. (doi: 10.1093/ehjqcco/qcz040)

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2019

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Avtaar Singh, S. S., Das De, S., Rushton, S., Berry, C., Al-Attar, N. (2019) PREDICTA: a model to predict primary graft dysfunction after adult heart transplantation in the United Kingdom. Journal of Cardiac Failure, 25, pp. 971-977. (doi: 10.1016/j.cardfail.2019.07.009)

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2018

Arnau-Soler, A., Adams, M. J., Generation Scotland, , Major Depressive Disorder Working Group, P. G. C., Hayward, C., Thomson, P. A. (2018) Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. PLoS ONE, 13, (doi: 10.1371/journal.pone.0209160)

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Strembitska, A., Mancini, S. J., Gamwell, J. M., Palmer, T. M., Baillie, G. S., Salt, I. P. (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase. International Journal of Molecular Sciences, 19, (doi: 10.3390/ijms19123886)

Kokubo, Y., Padmanabhan, S. (2018) Necessity of preventing cardiovascular disease by smoke-free policies. Journal of the American Heart Association, 7, (doi: 10.1161/JAHA.118.011120)

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Lang, N. N., Walker, N. L. (2018) Adult congenital heart disease and radiation exposure: the malignant price of cardiac care. Circulation, 137, pp. 1346-1348. (doi: 10.1161/CIRCULATIONAHA.117.032815)

Lee, M. M.Y. et al. (2018) Non-Invasive Versus Invasive Management in Patients With Prior Coronary Artery Bypass Surgery With a Non-ST Segment Elevation Acute Coronary Syndrome: Comparisons Between the Randomized Controlled Pilot Trial and Registry. (doi: 10.1016/S0735-1097(18)30586-2)

Weir, C. J., Butcher, I., Assi, V., Lewis, S. C., Murray, G. D., Langhorne, P., Brady, M. C. (2018) Dealing with missing standard deviation and mean values in meta-analysis of continuous outcomes: a systematic review. BMC Medical Research Methodology, 18, (doi: 10.1186/s12874-018-0483-0)

Al-Shahi Salman, R. et al. (2018) The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial. Trials, 19, (doi: 10.1186/s13063-018-2542-6)

Bath, P. M. et al. (2018) Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial. Lancet, 391, pp. 850-859. (doi: 10.1016/S0140-6736(17)32849-0)

Sung, Y. J. et al. (2018) A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure. American Journal of Human Genetics, 102, pp. 375-400. (doi: 10.1016/j.ajhg.2018.01.015)

Feng, Y.-M., Thijs, L., Zhang, Z.-Y., Yang, W.-Y., Huang, Q.-F., Wei, F.-F., Kuznetsova, T., Jennings, A.-M., Delles, C., Lennox, R., Verhamme, P., Dominiczak, A., Staessen, J. A. (2018) Glomerular function in relation to circulating adhesion molecules and inflammation markers in a general population. Nephrology Dialysis Transplantation, 33, pp. 426-435. (doi: 10.1093/ndt/gfx256)

Sellers, K. J., Elliott, C., Jackson, J., Ghosh, A., Ribe, E., Rojo, A. I., Jarosz-Griffiths, H. H., Watson, I. A., Xia, W., Semenov, M., Morin, P., Hooper, N. M., Porter, R., Preston, J., Al-Shawi, R., Baillie, G., Lovestone, S., Cuadrado, A., Harte, M., Simons, P., Srivastava, D. P., Killick, R. (2018) Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. Alzheimer's and Dementia, 14, pp. 306-317. (doi: 10.1016/j.jalz.2017.09.008)

Skrobot, O. A. et al. (2018) Progress toward standardized diagnosis of vascular cognitive impairment: guidelines from the Vascular Impairment of Cognition Classification Consensus Study. Alzheimer's and Dementia, 14, pp. 280-292. (doi: 10.1016/j.jalz.2017.09.007)

Chavan-Gautam, P., Rani, A., Freeman, D. J. (2018) Distribution of fatty acids and lipids during pregnancy. Elsevier

Corcoran, D., Young, R., Cialdella, P., McCartney, P., Bajrangee, A., Hennigan, B., Collison, D., Carrick, D., Shaukat, A., Good, R., Watkins, S., McEntegart, M., Watt, J., Welsh, P., Sattar, N., McConnachie, A., Oldroyd, K.G., Berry, C. (2018) The effects of remote ischaemic preconditioning on coronary artery function in patients with stable coronary artery disease. International Journal of Cardiology, 252, pp. 24-30. (doi: 10.1016/j.ijcard.2017.10.082)

Magnus, M. C., Lawlor, D. A., Iliodromiti, S., Padmanabhan, S., Nelson, S. M., Fraser, A. (2018) Age at menarche and cardiometabolic health: a sibling analysis in the Scottish Family Health Study. Journal of the American Heart Association, 7, (doi: 10.1161/JAHA.117.007780)

Currie, G., Delles, C. (2018) Blood pressure targets in the elderly. Journal of Hypertension, 36, pp. 234-236. (doi: 10.1097/HJH.0000000000001576)

Quinn, T. J., Elliott, E., Langhorne, P. (2018) Cognitive and mood assessment tools for use in stroke. Stroke, 49, pp. 483-490. (doi: 10.1161/STROKEAHA.117.016994)

Adamson, P. D., Hunter, A., Williams, M. C., Shah, A. S.V., McAllister, D. A., Pawade, T. A., Dweck, M. R., Mills, N. L., Berry, C., Boon, N. A., Clark, E., Flather, M., Forbes, J., McLean, S., Roditi, G., van Beek, E. J.R., Timmis, A. D., Newby, D. E. (2018) Diagnostic and prognostic benefits of computed tomography coronary angiography using the 2016 National Institute for Health and Care Excellence guidance within a randomised trial. Heart, 104, pp. 207-214. (doi: 10.1136/heartjnl-2017-311508)

Askim, T. et al. (2018) Efficacy and safety of individualized coaching after stroke: the LAST Study (Life After Stroke): a pragmatic randomized controlled trial. Stroke, 49, pp. 426-432. (doi: 10.1161/STROKEAHA.117.018827)

Adamson, P. D., Hunter, A., Madsen, D. M., Shah, A. S.V., McAllister, D. A., Pawade, T. A., Williams, M. C., Berry, C., Boon, N. A., Flather, M., Forbes, J., McLean, S., Roditi, G., Timmis, A. D., van Beek, E. J.R., Dweck, M. R., Mickley, H., Mills, N. L., Newby, D. E. (2018) High-sensitivity cardiac troponin I and the diagnosis of coronary artery disease in patients with suspected angina pectoris. Circulation: Cardiovascular Quality and Outcomes, 11, (doi: 10.1161/CIRCOUTCOMES.117.004227)

Ford, T. J., Corcoran, D., Berry, C. (2018) Stable coronary syndromes: pathophysiology, diagnostic advances and therapeutic need. Heart, 104, pp. 284-292. (doi: 10.1136/heartjnl-2017-311446)

Fertig, B. A., Baillie, G. S. (2018) PDE4-mediated cAMP signalling. Journal of Cardiovascular Development and Disease, 5, (doi: 10.3390/jcdd5010008)

Onyiaodike, C. C., Murray, H. M., Zhang, R., Meyer, B. J., Jordan, F., Brown, E. A., Nibbs, R. J.B., Lyall, H., Sattar, N., Nelson, S. M., Freeman, D. J. (2018) Pre-conception maternal erythrocyte saturated to unsaturated fatty acid ratio predicts pregnancy after natural cycle frozen embryo transfer. Scientific Reports, 8, (doi: 10.1038/s41598-018-19500-0)

Williams, J. J.L., Al-Otaiq, N., Mullen, W., Burchmore, R., Liu, L., Baillie, G. S., Schaper, F., Pilch, P. F., Palmer, T. M. (2018) Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nature Communications, 9, (doi: 10.1038/s41467-017-02585-y)

Gallacher, K. L., May, C. R., Langhorne, P., Mair, F. S. (2018) A conceptual model of treatment burden and patient capacity in stroke. BMC Family Practice, 19, (doi: 10.1186/s12875-017-0691-4)

McCarroll, C. S. et al. (2018) Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction. Circulation, 137, pp. 57-70. (doi: 10.1161/CIRCULATIONAHA.117.028911)

Rodrigues, A. L., Brescia, M., Kolshinski, A., Moreira, T. H., Cameron, R. T., Baillie, G., Beirão, P. S.L., Zaccollo, M., Cruz, J. S. (2018) Increase in Ca2+ current by sustained cAMP levels enhances proliferation rate in GH3 cells. Life Sciences, 192, pp. 144-150. (doi: 10.1016/j.lfs.2017.11.040)

Bihlmeyer, N. A. et al. (2018) ExomeChip-wide analysis of 95 626 individuals identifies 10 novel loci associated with QT and JT intervals. Circulation: Genomic and Precision Medicine, 11, (doi: 10.1161/CIRCGEN.117.001758)

Turcot, V. et al. (2018) Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics, 50, pp. 26-41. (doi: 10.1038/s41588-017-0011-x)

Maznyczka, A. M., McCartney, P., Berry, C. (2018) Reference invasive tests of microvascular injury in myocardial infarction. BMJ Open, 104, pp. 90-92. (doi: 10.1136/heartjnl-2017-311695)

Lee, M. M.Y. et al. (2018) Routine Non-invasive vs Invasive Management in Patients With Prior CABG With a NSTE-ACS: a Randomised Controlled Trial. (doi: 10.1136/heartjnl-2018-BCIS.9)

Souteyrand, G., Valladier, M., Amabile, N., Derimay, F., Harbaoui, B., Leddet, P., Barnay, P., Malcles, G., Mulliez, A., Berry, C., Eschalier, R., Combaret, N., Motreff, P. (2018) Diagnosis and management of spontaneously recanalized coronary thrombus guided by optical coherence tomography ― lessons from the French “Lotus Root” registry ― Circulation Journal, 82, pp. 783-790. (doi: 10.1253/circj.cj-17-0810)

Yalla, K., Elliott, C., Day, J.P., Findlay, J., Barratt, S., Hughes, Z.A., Wilson, L., Whiteley, E., Popiolek, M., Li, Y., Dunlop, J., Killick, R., Adams, D.R., Brandon, N.J., Houslay, M.D., Hao, B., Baillie, G.S. (2018) FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system. Molecular Psychiatry, 23, pp. 1278-1286. (doi: 10.1038/mp.2017.138)

Padmanabhan, S., Tan, L.-E., Dominiczak, A. F. (2018) Genetics of blood pressure and hypertension. Springer

Berry, C., Carberry, J., Mangion, K. (2018) How to mend a broken heart? JACC: Cardiovascular Imaging, 11, pp. 420-422. (doi: 10.1016/j.jcmg.2017.02.017)

Layland, J., Tong, D., Lee, M., Berry, C. (2018) ST and T-Wave Abnormality as Footprint of Myocardial Oedema in Non–ST-Elevation Myocardial Infarction. (doi: 10.1016/j.hlc.2018.06.515)

Delles, C., Carrick, E., Graham, D., Nicklin, S. A. (2018) Utilising proteomics to understand and define hypertension: where are we and where do we go? Expert Review of Proteomics, 15, pp. 581-592. (doi: 10.1080/14789450.2018.1493927)

2017

Avtaar Singh, S. S., Das De, S., Spadaccio, C., Berry, C., Al-Attar, N. (2017) An overview of different methods of myocardial protection currently employed peri-transplantation. Vessel Plus, 1, pp. 213-229. (doi: 10.20517/2574-1209.2017.26)

Van't Veer, M., Pijls, N. H.J., Hennigan, B., Watkins, S., Ali, Z. A., De Bruyne, B., Zimmermann, F. M., van Nunen, L. X., Barbato, E., Berry, C., Oldroyd, K. G. (2017) Comparison of different diastolic resting indexes to iFR: are they all equal? Journal of the American College of Cardiology, 70, pp. 3088-3096. (doi: 10.1016/j.jacc.2017.10.066)

Ford, T. J., Berry, C., De Bruyne, B., Yong, A. C.S., Barlis, P., Fearon, W. F., Ng, M. K.C. (2017) Physiological predictors of acute coronary syndromes: emerging insights from the plaque to the vulnerable patient. JACC: Cardiovascular Interventions, 10, pp. 2539-2547. (doi: 10.1016/j.jcin.2017.08.059)

Berry, C., McClure, J. D., Oldroyd, K. G. (2017) Meta-analysis of death and myocardial infarction in the DEFINE-FLAIR and iFR-SWEDEHEART trials: a hypothesis generating note of caution. Circulation, 136, pp. 2389-2391. (doi: 10.1161/CIRCULATIONAHA.117.030430)

Urimubenshi, G., Langhorne, P., Cadilhac, D. A., Kagwiza, J. N., Wu, O. (2017) Association between patient outcomes and key performance indicators of stroke care quality: A systematic review and meta-analysis. European Stroke Journal, 2, pp. 287-307. (doi: 10.1177/2396987317735426)

Basole, C. P., Nguyen, R. K., Lamothe, K., Vang, A., Clark, R., Baillie, G. S., Epstein, P. M., Brocke, S. (2017) PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex. Cellular Signalling, 40, pp. 62-72. (doi: 10.1016/j.cellsig.2017.08.007)

Carberry, J., Carrick, D., Haig, C., Ahmed, N., Mordi, I., McEntegart, M., Petrie, M. C., Eteiba, H., Hood, S., Watkins, S., Lindsay, M., Davie, A., Mahrous, A., Ford, I., Sattar, N., Welsh, P., Radjenovic, A., Oldroyd, K. G., Berry, C. (2017) Persistence of infarct zone T2 hyperintensity at 6 months after acute ST-elevation myocardial infarction: incidence, pathophysiology and prognostic implications. Circulation: Cardiovascular Imaging, 10, (doi: 10.1161/CIRCIMAGING.117.006586)

O'Neill, D.G., Riddell, A., Church, D.B., Owen, L., Brodbelt, D.C., Hall, J.L. (2017) Urinary incontinence in bitches under primary veterinary care in England: prevalence and risk factors. Journal of Small Animal Practice, 58, pp. 685-693. (doi: 10.1111/jsap.12731)

Krochmal, M., Kontostathi, G., Magalhães, P., Makridakis, M., Klein, J., Husi, H., Leierer, J., Mayer, G., Bascands, J.-L., Denis, C., Zoidakis, J., Zürbig, P., Delles, C., Schanstra, J. P., Mischak, H., Vlahou, A. (2017) Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy. Scientific Reports, 7, (doi: 10.1038/s41598-017-15359-9)

MacDonald, T. M., Williams, B., Webb, D. J., Morant, S., Caulfield, M., Cruickshank, J. K., Ford, I., Sever, P., Mackenzie, I. S., Padmanabhan, S., McCann, G. P., Salsbury, J., McInnes, G., Brown, M. J. (2017) Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension: a double-blind randomized controlled trial. Journal of the American Heart Association, 6, (doi: 10.1161/JAHA.117.006986)

Mary, S., Kulkarni, M. J., Mehendale, S. S., Joshi, S. R., Giri, A. P. (2017) Differential accumulation of vimentin fragments in preeclamptic placenta. Cytoskeleton, 74, pp. 420-425. (doi: 10.1002/cm.21390)

MacDonald, E. A., Stoyek, M. R., Rose, R. A., Quinn, T. A. (2017) Intrinsic regulation of sinoatrial node function and the zebrafish as a model of stretch effects on pacemaking. Progress in Biophysics and Molecular Biology, 130, pp. 198-211. (doi: 10.1016/j.pbiomolbio.2017.07.012)

Pontillo, C. et al. (2017) Prediction of chronic kidney disease stage 3 by CKD273, a urinary proteomic biomarker. Kidney International Reports, 2, pp. 1066-1075. (doi: 10.1016/j.ekir.2017.06.004)

Schmieder, R. E., Wagner, F., Mayr, M., Delles, C., Ott, C., Keicher, C., Hrabak-Paar, M., Heye, T., Aichner, S., Khder, Y., Yates, D., Albrecht, D., Langenickel, T., Freyhardt, P., Janka, R., Bremerich, J. (2017) The effect of sacubitril/valsartan compared to olmesartan on cardiovascular remodelling in subjects with essential hypertension: the results of a randomized, double-blind, active-controlled study. European Heart Journal, 38, pp. 3308-3317. (doi: 10.1093/eurheartj/ehx525)

Rutherford, E., Mangion, K., Mccomb, C., Bell, E., Cockburn, S., Talle, M., Roditi, G., Welsh, P., Woodward, R., Radjenovic, A., Struthers, A. D., Jardine, A., Berry, C., Patel, R. K., Mark, P. B. (2017) Myocardial changes in incident haemodialysis patients over 6-months: an observational cardiac magnetic resonance imaging study. Scientific Reports, 7, (doi: 10.1038/s41598-017-14481-y)

Kobayashi, Y., Johnson, N. P., Zimmermann, F. M., Witt, N., Berry, C., Jeremias, A., Koo, B.-K., Esposito, G., Rioufol, G., Park, S.-J., Nishi, T., Choi, D.-H., Oldroyd, K. G., Barbato, E., Pijls, N. H. J., De Bruyne, B., Fearon, W. F. (2017) Agreement of the resting distal to aortic coronary pressure with the instantaneous wave-free ratio. Journal of the American College of Cardiology, 70, pp. 2105-2113. (doi: 10.1016/j.jacc.2017.08.049)

Shepperd, S., Cradduck-Bamford, A., Butler, C., Ellis, G., Godfrey, M., Gray, A., Hemsley, A., Khanna, P., Langhorne, P., McCaffrey, P., Mirza, L., Pushpangadan, M., Ramsay, S., Schiff, R., Stott, D., Young, J., Yu, L.-M. (2017) A multi-centre randomised trial to compare the effectiveness of geriatrician-led admission avoidance hospital at home versus inpatient admission. Trials, 18, (doi: 10.1186/s13063-017-2214-y)

Lemonidis, K., MacLeod, R., Baillie, G. S., Chamberlain, L. H. (2017) Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase. Journal of Biological Chemistry, 292, pp. 17190-17202. (doi: 10.1074/jbc.M117.799650)

Gao, H., Mangion, K., Carrick, D., Husmeier, D., Luo, X., Berry, C. (2017) Estimating prognosis in patients with acute myocardial infarction using personalized computational heart models. Scientific Reports, 7, (doi: 10.1038/s41598-017-13635-2)

Kohli-Lynch, C.N., Boyd, K., Briggs, A., Delles, C. (2017) A Framework for the Cost-Effectiveness Analysis of Novel Biomarker Testing in Cardiovascular Disease. (doi: 10.1016/j.jval.2017.08.040)

Stevens, K., Denby, L., Patel, R. K., Mark, P. B., Kettlewell, S., Smith, G. L., Clancy, M. J., Delles, C., Jardine, A. G. (2017) Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway. Nephrology Dialysis Transplantation, 32, pp. 1617-1627. (doi: 10.1093/ndt/gfw252)

Clarke, T.-K., Adams, M.J., Davies, G., Howard, D.M., Hall, L.S., Padmanabhan, S., Murray, A.D., Smith, B.H., Campbell, A., Hayward, C., Porteous, D.J., Deary, I.J., McIntosh, A.M. (2017) Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117) Molecular Psychiatry, 22, pp. 1376-1384. (doi: 10.1038/mp.2017.153)

Nishi, T., Johnson, N. P., De Bruyne, B., Berry, C., Gould, K. L., Jeremias, A., Oldroyd, K. G., Kobayashi, Y., Choi, D.-H., Pijls, N. H.J., Fearon, W. F. (2017) Influence of contrast media dose and osmolality on the diagnostic performance of contrast fractional flow reserve. Circulation: Cardiovascular Interventions, 10, (doi: 10.1161/CIRCINTERVENTIONS.117.004985)

Gao, H., Qi, N., Feng, L., Ma, X., Danton, M., Berry, C., Luo, X. (2017) Modelling mitral valvular dynamics–current trend and future directions. International Journal for Numerical Methods in Biomedical Engineering, 33, (doi: 10.1002/cnm.2858)

Queen, A. B., Lowrie, R., Richardson, J., Williamson, A. E. (2017) Multimorbidity, disadvantage and patient engagement within a specialist homeless health service in the UK. BJGP Open, 1, (doi: 10.3399/bjgpopen17X100941)

Kraja, A. T. et al. (2017) New blood pressure–associated loci identified in meta-analyses of 475 000 individuals. Circulation: Cardiovascular Genetics, 10, (doi: 10.1161/CIRCGENETICS.117.001778)

Padmanabhan, S., Joe, B. (2017) Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans. Physiological Reviews, 97, pp. 1469-1528. (doi: 10.1152/physrev.00035.2016)

Jayabalan, N., Nair, S., Nuzhat, Z., Rice, G. E., Zúñiga, F. A., Sobrevia, L., Leiva, A., Sanhueza, C., Agustin Gutierrez, J., Lappas, M., Freeman, D. J., Salomon, C. (2017) Cross talk between adipose tissue and placenta in obese and gestational diabetes mellitus pregnancies via exosomes. Frontiers in Endocrinology, 8, (doi: 10.3389/fendo.2017.00239)

Ellis, G., Gardner, M., Tsiachristas, A., Langhorne, P., Burke, O., Harwood, R. H., Conroy, S. P., Kircher, T., Somme, D., Saltvedt, I., Wald, H., O'Neill, D., Robinson, D., Shepperd, S. (2017) Comprehensive geriatric assessment for older adults admitted to hospital. Cochrane Database of Systematic Reviews, 2017, (doi: 10.1002/14651858.cd006211.pub3)

Noh, R. M., Venkatasubramanian, S., Daga, S., Langrish, J., Mills, N. L., Lang, N. N., Hoffmann, E., Waterhouse, B., Newby, D. E., Frier, B. M. (2017) Cardiometabolic effects of a novel SIRT1 activator, SRT2104, in people with type 2 diabetes mellitus. Open Heart, 4, (doi: 10.1136/openhrt-2017-000647)

Zeng, Y. et al. (2017) Genome-wide regional heritability mapping identifies a locus within the TOX2 gene associated with major depressive disorder. Biological Psychiatry, 82, pp. 312-321. (doi: 10.1016/j.biopsych.2016.12.012)

Langhorne, P., Wu, O., Rodgers, H., Ashburn, A., Bernhardt, J. (2017) A Very Early Rehabilitation Trial after stroke (AVERT): a Phase III, multicentre, randomised controlled trial. Health Technology Assessment, 21, pp. 1-120. (doi: 10.3310/hta21540)

Gao, H., Feng, L., Qi, N., Berry, C., Griffith, B. E., Luo, X. (2017) A coupled mitral valve - left ventricle model with fluid-structure interaction. Medical Engineering and Physics, 47, pp. 128-136. (doi: 10.1016/j.medengphy.2017.06.042)

Che Roos, N. A., Alsanosi, S. M., Alsieni, M. A., Gupta, M., Padmanabhan, S. (2017) Antihypertensive Drugs and Risk of Cancer: A Systematic Review and Meta-Analysis of 391, 790 Patients. (doi: 10.1161/hyp.70.suppl_1.p129)

Bagot, C.N., Leishman, E., Onyiaodike, C.C., Jordan, F., Freeman, D.J. (2017) Normal pregnancy is associated with an increase in thrombin generation from the very early stages of the first trimester. Thrombosis Research, 157, pp. 49-54. (doi: 10.1016/j.thromres.2017.06.027)

Wain, L. V. et al. (2017) Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney. Hypertension, 70, pp. e4-e19. (doi: 10.1161/HYPERTENSIONAHA.117.09438)

Krochmal, M., Cisek, K., Filip, S., Markoska, K., Orange, C., Zoidakis, J., Gakiopoulou, C., Spasovski, G., Mischak, H., Delles, C., Vlahou, A., Jankowski, J. (2017) Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis. Scientific Reports, 7, (doi: 10.1038/s41598-017-09393-w)

Gao, X., Salomon, C., Freeman, D. J. (2017) Extracellular vesicles from adipose tissue - a potential role in obesity and type 2 diabetes? Frontiers in Endocrinology, 8, (doi: 10.3389/fendo.2017.00202)

Lindley, R. I. et al. (2017) Family-led rehabilitation after stroke in India (ATTEND): a randomised controlled trial. Lancet, 390, pp. 588-599. (doi: 10.1016/S0140-6736(17)31447-2)

Robertson, S., Diver, L. A., Alvarez-Madrazo, S., Livie, C., Ejaz, A., Fraser, R., Connell, J. M., MacKenzie, S. M., Davies, E. (2017) Regulation of corticosteroidogenic genes by microRNAs. International Journal of Endocrinology, 2017, (doi: 10.1155/2017/2021903)

Berry, C. (2017) Stable coronary syndromes: the case for consolidating the nomenclature of stable ischemic heart disease. Circulation, 136, pp. 437-439. (doi: 10.1161/CIRCULATIONAHA.117.028991)

Bhat, S., Mary, S., Giri, A. P., Kulkarni, M. J. (2017) Advanced glycation end products (AGEs) in diabetic complications. Springer

Newby, D. et al. (2017) Aortic wall inflammation predicts abdominal aortic aneurysm expansion, rupture, and need for surgical repair. Circulation, 136, pp. 787-797. (doi: 10.1161/CIRCULATIONAHA.117.028433)

Wigmore, E. M., Clarke, T.-K., Howard, D. M., Adams, M. J., Hall, L. S., Zeng, Y., Gibson, J., Davies, G., Fernandez-Pujals, A. M., Thomson, P. A., Hayward, C., Smith, B. H., Hocking, L. J., Padmanabhan, S., Deary, I. J., Porteous, D. J., Nicodemus, K. K., McIntosh, A. M. (2017) Do regional brain volumes and major depressive disorder share genetic architecture? A study of Generation Scotland (n=19 762), UK Biobank (n=24 048) and the English Longitudinal Study of Ageing (n=5766) Translational Psychiatry, 7, (doi: 10.1038/tp.2017.148)

Currie, G., Delles, C. (2017) Healthy vascular ageing. Hypertension, 70, pp. 229-231. (doi: 10.1161/HYPERTENSIONAHA.117.09122)

Mangion, K., McComb, C., Auger, D. A., Epstein, F. H., Berry, C. (2017) Magnetic resonance imaging of myocardial strain after acute ST-segment-elevation myocardial infarction: a systematic review. Circulation: Cardiovascular Imaging, 10, (doi: 10.1161/CIRCIMAGING.117.006498)

Small, H. Y., Cornelius, D. C., Guzik, T. J., Delles, C. (2017) Natural killer cells in placentation and cancer: Implications for hypertension during pregnancy. Placenta, 56, pp. 59-64. (doi: 10.1016/j.placenta.2017.03.003)

Zhang, Z.‐Y., Ravassa, S., Nkuipou‐Kenfack, E., Yang, W.-Y., Kerr, S. M., Koeck, T., Campbell, A., Kuznetsova, T., Mischak, H., Padmanabhan, S., Dominiczak, A. F., Delles, C., Staessen, J. A. (2017) Novel urinary peptidomic classifier predicts incident heart failure. Journal of the American Heart Association, 6, (doi: 10.1161/JAHA.116.005432)

Gajjala, P. R., Jankowski, V., Heinze, G., Bilo, G., Zanchetti, A., Noels, H., Liehn, E., Perco, P., Schulz, A., Delles, C., Kork, F., Biessen, E., Narkiewicz, K., Kawecka-Jaszcz, K., Floege, J., Soranna, D., Zidek, W., Jankowski, J. (2017) Proteomic-biostatistic integrated approach for finding the underlying molecular determinants of hypertension in human plasma. Hypertension, 70, pp. 412-419. (doi: 10.1161/HYPERTENSIONAHA.116.08906)

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Durussel, J., Haile, D., Mooses, K., Daskalaki, E., Beattie, W., Mooses, M., Mekonen, W., Ongaro, N., Anjila, E., Patel, R., Padmanabhan, N., McBride, M., McClure, J., Pitsiladis, Y. (2016) Blood transcriptional signature of recombinant human erythropoietin administration and implications for antidoping strategies. Physiological Genomics, 48, pp. 202-209. (doi: 10.1152/physiolgenomics.00108.2015)

MacIsaac, R., Janek, S., Higgins, P., Walters, M. R., Padmanabhan, S., Dominiczak, A. F., Touyz, R. M., Dawson, J. (2016) Allopurinol and cardiovascular outcomes in adults with hypertension. Hypertension, 67, pp. 535-540. (doi: 10.1161/HYPERTENSIONAHA.115.06344)

Clarke, T.-K., Lupton, M.K., Fernandez-Pujals, A.M., Starr, J., Davies, G., Cox, S., Pattie, A., Liewald, D.C., Hall, L.S., MacIntyre, D.J., Smith, B.H., Hocking, L.J., Padmanabhan, S., Thomson, P.A., Hayward, C., Hansell, N.K., Montgomery, G.W., Medland, S.E., Martin, N.G., Wright, M.J., Porteous, D.J., Deary, I.J., McIntosh, A.M. (2016) Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population. Molecular Psychiatry, 21, pp. 419-425. (doi: 10.1038/mp.2015.12)

Mullan, A., Delles, C., Ferrell, W., Mullen, W., Edwards, C. A., McColl, J. H., Roberts, S. A., Lean, M. (2016) Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized trial. Atherosclerosis, 246, pp. 169-176. (doi: 10.1016/j.atherosclerosis.2016.01.004)

Wilson, R., Aung, H., Ju, X., Paterson, C., Sayer, R., McIntyre, A., Going, J., Irvine, R., Berry, C. (2016) Optical coherence tomography: an experimental validation for vascular imaging of saphenous vein bypass grafts. Biomedical Physics and Engineering Express, 2, (doi: 10.1088/2057-1976/2/2/025002)

Clarke, T.-K., Smith, A. H., Gelernter, J., Kranzler, H. R., Farrer, L. A., Hall, L. S., Fernandez-Pujals, A. M., MacIntyre, D. J., Smith, B. H., Hocking, L. J., Padmanabhan, S., Hayward, C., Thomson, P. A., Porteous, D. J., Deary, I. J., McIntosh, A. M. (2016) Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort. Addiction Biology, 21, pp. 469-480. (doi: 10.1111/adb.12245)

Gibson, G., Xia, C., Amador, C., Huffman, J., Trochet, H., Campbell, A., Porteous, D., Generation Scotland, , Hastie, N. D., Hayward, C., Vitart, V., Navarro, P., Haley, C. S. (2016) Pedigree- and SNP-associated genetics and recent environment are the major contributors to anthropometric and cardiometabolic trait variation. PLoS Genetics, 12, (doi: 10.1371/journal.pgen.1005804)

Padmanabhan, S., Touyz, R. M. (2016) Precision medicine in hypertension. Biochemist, 38, pp. 35-38. (doi: 10.1042/BIO03801035)

Currie, G., Delles, C., Touyz, R. M., Staessen, J. A., Dominiczak, A. F., Jennings, G. L. R., Wang, J.-G. (2016) A woman with treatment-resistant hypertension. Hypertension, 67, pp. 243-250. (doi: 10.1161/HYPERTENSIONAHA.115.06756)

Pollock, A., Farmer, S. E., Brady, M. C., Langhorne, P., Mead, G. E., Mehrholz, J., van Wijck, F., Wiffen, P. J. (2016) An algorithm was developed to assign GRADE levels of evidence to comparisons within systematic reviews. Journal of Clinical Epidemiology, 70, pp. 106-110. (doi: 10.1016/j.jclinepi.2015.08.013)

Brown, M. J., Williams, B., Morant, S. V., Webb, D. J., Caulfield, M. J., Cruickshank, J. K., Ford, I., McInnes, G., Sever, P., Salsbury, J., Mackenzie, I. S., Padmanabhan, S., MacDonald, T. M. (2016) Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial. Lancet Diabetes and Endocrinology, 4, pp. 136-147. (doi: 10.1016/s2213-8587(15)00377-0)

Small, H. Y., Currie, G. E., Delles, C. (2016) Prostasin, proteases, and preeclampsia. Journal of Hypertension, 34, pp. 193-195. (doi: 10.1097/hjh.0000000000000828)

Turner, M., Barber, M., Dodds, H., Dennis, M., Langhorne, P., Macleod, M.-J. (2016) Stroke patients admitted within normal working hours are more likely to achieve process standards and to have better outcomes. Journal of Neurology, Neurosurgery and Psychiatry, 87, pp. 138-143. (doi: 10.1136/jnnp-2015-311273)

Johnson, M. R. et al. (2016) Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease. Nature Neuroscience, 19, pp. 223-232. (doi: 10.1038/nn.4205)

Carrick, D., Haig, C., Rauhalammi, S., Clerfond, G., Ahmed, N., Mordi, I., McEntegart, M., Petrie, M., Eteiba, H., Hood, S., Watkins, S., Lindsay, M. M., Mahrous, A., Welsh, P., Sattar, N., Ford, I., Oldroyd, K., Radjenovic, A., Berry, C. (2016) Temporal evolution of myocardial hemorrhage and edema in patients after acute ST-elevation myocardial infarction: pathophysiologic insights and clinical implications. Journal of the American Heart Association, 5, (doi: 10.1161/JAHA.115.002834)

Watt, J., Kennedy, S., Ahmed, N., Hayhurst, J., McClure, J. D., Berry, C., Wadsworth, R. M., Oldroyd, K. G. (2016) The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD. Open Heart, 3, (doi: 10.1136/openhrt-2015-000342)

Rankinen, T. et al. (2016) No evidence of a common DNA variant profile specific to world class endurance athletes. PLoS ONE, 11, (doi: 10.1371/journal.pone.0147330)

Mangion, K., Gao, H., Radjenovic, A., Luo, X., Haig, C., Berry, C. (2016) Pixel-tracking derived strain using the GlasgowHeart Method. Journal of Cardiovascular Magnetic Resonance, 18, (doi: 10.1186/1532-429X-18-S1-P9)

Alim, M., Lindley, R., Felix, C., Gandhi, D. B. C., Verma, S. J., Tugnawat, D. K., Syrigapu, A., Anderson, C. S., Ramamurthy, R. K., Langhorne, P., Murthy, G. V. S., Shamanna, B. R., Hackett, M. L., Maulik, P. K., Harvey, L. A., Jan, S., Liu, H., Walker, M., Forster, A., Pandian, J. D. (2016) Family-led rehabilitation after stroke in India: the ATTEND trial, study protocol for a randomized controlled trial. Trials, 17, (doi: 10.1186/s13063-015-1129-8)

Dachtler, J., Elliott, C., Rodgers, R. J., Baillie, G. S., Clapcote, S. J. (2016) Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice. Scientific Reports, 6, (doi: 10.1038/srep18748)

Ahmed, N., Layland, J., Carrick, D., Petrie, M. C., McEntegart, M., Eteiba, H., Hood, S., Lindsay, M., Watkins, S., Davie, A., Mahrous, A., Carberry, J., Teng, V., McConnachie, A., Curzen, N., Oldroyd, K. G., Berry, C. (2016) Safety of guidewire-based measurement of fractional flow reserve and the index of microvascular resistance using intravenous adenosine in patients with acute or recent myocardial infarction. International Journal of Cardiology, 202, pp. 305-310. (doi: 10.1016/j.ijcard.2015.09.014)

Small, H. Y., Morgan, H., Beattie, E., Griffin, S., Indahl, M., Delles, C., Graham, D. (2016) Abnormal uterine artery remodelling in the stroke prone spontaneously hypertensive rat. Placenta, 37, pp. 34-44. (doi: 10.1016/j.placenta.2015.10.022)

Abdul-Rahim, A. H., Quinn, T. J., Alder, S., Clark, A. B., Musgrave, S., Langhorne, P., Potter, J. F., Myint, P. K. (2016) Derivation and validation of a novel prognostic scale (modified–stroke subtype, Oxfordshire community stroke project classification, age, and prestroke modified rankin) to predict early mortality in acute stroke. Stroke, 47, pp. 74-79. (doi: 10.1161/strokeaha.115.009898)

Baillie, G. S., Christian, F., Zarros, A. (2016) Editorial: frontiers in the pharmacological manipulation of intracellular cAMP levels. Frontiers in Pharmacology, 7, (doi: 10.3389/fphar.2016.00004)

Jenkins, P., Sng, S., Brooksbank, K., Brooksbank, A.J. (2016) Socioeconomic deprivation and age are barriers to the online collection of patient reported outcome measures in orthopaedic patients. Annals of the Royal College of Surgeons of England, 98, pp. 40-44. (doi: 10.1308/rcsann.2016.0007)

Olsen, M. H., Angell, S. Y., Asma, S., Boutouyrie, P., Burger, D., Chirinos, J. A., Damasceno, A., Delles, C., Gimenez-Roqueplo, A.-P., Hering, D., López-Jaramillo, P., Martinez, F., Perkovic, V., Rietzschel, E. R., Schillaci, G., Schutte, A. E., Scuteri, A., Sharman, J. E., Wachtell, K., Wang, J. G. (2016) A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension. Lancet, 388, pp. 2665-2712. (doi: 10.1016/S0140-6736(16)31134-5)

Boulberdaa, M., Scott, E., Ballantyne, M., Garcia, R., Descamps, B., Angelini, G. D., Brittan, M., Hunter, A., McBride, M., McClure, J., Miano, J. M., Emanueli, C., Mills, N. L., Mountford, J. C., Baker, A. H. (2016) A role for the long non-coding RNA SENCR in commitment and function of endothelial cells. Molecular Therapy, 24, pp. 978-990. (doi: 10.1038/mt.2016.41)

Nuesch, E. et al. (2016) Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. International Journal of Epidemiology, 45, pp. 1927-1937. (doi: 10.1093/ije/dyv074)

Kishore, A. K., Vail, A., Bray, B. D., Chamorro, A., Napoli, M. D., Kalra, L., Langhorne, P., Montaner, J., Roffe, C., Rudd, A. G., Tyrrell, P. J., de Beek, D. v., Woodhead, M., Meisel, A., Smith, C. J. (2016) Clinical risk scores for predicting stroke-associated pneumonia: a systematic review. European Stroke Journal, 1, pp. 76-84. (doi: 10.1177/2396987316651759)

Zhang, Z.-y., Ravassa, S., Yang, W.-Y., Petit, T., Pejchinovski, M., Zürbig, P., López, B., Wei, F.-F., Pontillo, C., Thijs, L., Jacobs, L., González, A., Koeck, T., Delles, C., Voigt, J.-U., Verhamme, P., Kuznetsova, T., Díez, J., Mischak, H., Staessen, J. A. (2016) Diastolic left ventricular function in relation to urinary and serum collagen biomarkers in a general population. PLoS ONE, 11, (doi: 10.1371/journal.pone.0167582)

(2016) Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels. (doi: 10.3389/978-2-88919-815-3)

McCallum, J. E., Mackenzie, A. E., Divorty, N., Clarke, C., Delles, C., Milligan, G., Nicklin, S. A. (2016) G protein-coupled receptor 35 mediates human saphenous vein vascular smooth muscle cell migration and endothelial cell proliferation. Journal of Vascular Research, 52, pp. 383-395. (doi: 10.1159/000444754)

Horikoshi, M. et al. (2016) Genome-wide associations for birth weight and correlations with adult disease. Nature, 538, pp. 248-252. (doi: 10.1038/nature19806)

O'Donnell, M. J. et al. (2016) Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study. Lancet, 388, pp. 761-775. (doi: 10.1016/S0140-6736(16)30506-2)

Corcoran, D., Berry, C. (2016) How to measure myocardial infarct size by cardiac magnetic resonance imaging. Heart and Metabolism, 70, pp. 14-18.

Mangion, K., Carrick, D., Hennigan, B. W., Payne, A. R., McClure, J., Mason, M., Das, R., Wilson, R., Edwards, R. J., Petrie, M. C., McEntegart, M., Eteiba, H., Oldroyd, K. G., Berry, C. (2016) Infarct size and left ventricular remodelling after preventive percutaneous coronary intervention. Heart, 102, pp. 1980-1987. (doi: 10.1136/heartjnl-2015-308660)

Meyer, B. J., Onyiaodike, C. C., Brown, E. A., Jordan, F., Murray, H., Nibbs, R. J. B., Sattar, N., Lyall, H., Nelson, S. M., Freeman, D. J. (2016) Maternal plasma DHA levels increase prior to 29 days post-LH surge in women undergoing frozen embryo transfer: a prospective, observational study of human pregnancy. Journal of Clinical Endocrinology and Metabolism, 101, pp. 1745-1753. (doi: 10.1210/jc.2015-3089)

Carrick, D., Haig, C., Watkins, S., Ahmed, N., McEntegart, M., Petrie, M. C., Eteiba, H., Hood, S., Watkins, S., Lindsay, M. M., Davie, A., Mahrous, A., Mordi, I., Rauhalammi, S., Sattar, N., Welsh, P., Radjenovic, A., Ford, I., Oldroyd, K., Berry, C. (2016) Myocardial hemorrhage after acute reperfused ST-segment-elevation myocardial infarction. Circulation: Cardiovascular Imaging, 9, (doi: 10.1161/CIRCIMAGING.115.004148)

Mangion, K., Corcoran, D., Carrick, D., Berry, C. (2016) New perspectives on the role of cardiac magnetic resonance imaging to evaluate myocardial salvage and myocardial hemorrhage after acute reperfused ST-elevation myocardial infarction. Expert Review of Cardiovascular Therapy, 14, pp. 843-854. (doi: 10.1586/14779072.2016.1173544)

Gillis, K. A., Mccomb, C., Patel, R. K., Stevens, K. K., Schneider, M. P., Radjenovic, A., Morris, S. T.W., Roditi, G. H., Delles, C., Mark, P. B. (2016) Non-contrast renal magnetic resonance imaging to assess perfusion and corticomedullary differentiation in health and chronic kidney disease. Nephron, 133, pp. 183-192. (doi: 10.1159/000447601)

Lindhardt, M., Persson, F., Currie, G., Pontillo, C., Beige, J., Delles, C., von der Leyen, H., Mischak, H., Navis, G., Noutsou, M., Ortiz, A., Ruggenenti, P. L., Rychlik, I., Spasovski, G., Rossing, P. (2016) Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy in TYpe 2 diabetic patients with normoalbuminuria (PRIORITY): essential study design and rationale of a randomised clinical multicentre trial. BMJ Open, 6, (doi: 10.1136/bmjopen-2015-010310)

Brkic, L., Shaw, L., van Wijck, F., Francis, R., Price, C., Forster, A., Langhorne, P., Watkins, C., Rodgers, H. (2016) Repetitive arm functional tasks after stroke (RAFTAS): a pilot randomised controlled trial. Pilot and Feasibility Studies, 2, (doi: 10.1186/s40814-016-0088-5)

Tankou, S., Ishii, K., Elliott, C., Yalla, K., Kubo, K.-i., Brandon, N. J., Tang, Q., Hayward, G., Nakajima, K., Houslay, M., Kamiya, A., Baillie, G., Ishizuka, K., Sawa, A. (2016) SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex. Molecular Neuropsychiatry, 2, pp. 20-27. (doi: 10.1159/000444257)

Sheikh, A. M., Small, H. Y., Currie, G., Delles, C. (2016) Systematic review of micro-RNA expression in pre-eclampsia identifies a number of common pathways associated with the disease. PLoS ONE, 11, (doi: 10.1371/journal.pone.0160808)

Hoffmann, T.C., Walker, M.F., Langhorne, P., Eames, S., Thomas, E., Glasziou, P. (2016) What's in a name? The challenge of describing interventions in systematic reviews: analysis of a random sample of reviews of non-pharmacological stroke interventions. BMJ Open, 5, (doi: 10.1136/bmjopen-2015-009051)

Baeza-Raja, B., Sachs, B. D., Li, P., Christian, F., Vagena, E., Davalos, D., Le Moan, N., Ryu, J. K., Sikorski, S. L., Chan, J. P., Scadeng, M., Taylor, S. S., Houslay, M. D., Baillie, G. S., Saltiel, A. R., Olefsky, J. M., Akassoglou, K. (2016) p75 neurotrophin receptor regulates energy balance in obesity. Cell Reports, 14, pp. 255-268. (doi: 10.1016/j.celrep.2015.12.028)

2015

Cameron, A. C., Touyz, R. M., Lang, N. N. (2015) Vascular complications of cancer chemotherapy. Canadian Journal of Cardiology, 32, pp. 852-862. (doi: 10.1016/j.cjca.2015.12.023)

Bernhardt, J., Lindley, R. I., Lalor, E., Ellery, F., Chamberlain, J., Van Holsteyn, J., Collier, J. M., Dewey, H. M., Parsons, B., Moodie, M., Lennon, S., Donnan, G. A., Thrift, A. G., Churilov, L., Langhorne, P. (2015) AVERT2(a very early rehabilitation trial, a very effective reproductive trigger): retrospective observational analysis of the number of babies born to trial staff. British Medical Journal, 351, (doi: 10.1136/bmj.h6432)

Berry, C., Corcoran, D., Hennigan, B., Watkins, S., Layland, J., Oldroyd, K. G. (2015) Fractional flow reserve-guided management in stable coronary disease and acute myocardial infarction: recent developments. European Heart Journal, 36, pp. 3155-3164. (doi: 10.1093/eurheartj/ehv206)

Solbu, M. D., Thomson, P. C., Macpherson, S., Findlay, M. D., Stevens, K. K., Patel, R. K., Padmanabhan, S., Jardine, A. G., Mark, P. B. (2015) Serum phosphate and social deprivation independently predict all-cause mortality in chronic kidney disease. BMC Nephrology, 16, (doi: 10.1186/s12882-015-0187-1)

Turner, M., Barber, M., Dodds, H., Dennis, M., Langhorne, P., Macleod, M.-J. (2015) Agreement between routine electronic hospital discharge and Scottish stroke care audit (SSCA) data in identifying stroke in the Scottish population. BMC Health Services Research, 15, (doi: 10.1186/s12913-015-1244-y)

Linneberg, A. et al. (2015) Effect of smoking on blood pressure and resting heart rate: a Mendelian randomization meta-analysis in the CARTA Consortium. Circulation: Cardiovascular Genetics, 8, pp. 832-841. (doi: 10.1161/circgenetics.115.001225)

Nam, J., Briggs, A., Layland, J., Oldroyd, K. G., Curzen, N., Sood, A., Balachandran, K., Das, R., Junejo, S., Eteiba, H., Petrie, M. C., Lindsay, M., Watkins, S., Corbett, S., O'Rourke, B., O'Donnell, A., Stewart, A., Hannah, A., McConnachie, A., Henderson, R., Berry, C. (2015) Fractional flow reserve (FFR) versus angiography in guiding management to optimise outcomes in non-ST segment elevation myocardial infarction (FAMOUS-NSTEMI) developmental trial: cost-effectiveness using a mixed trial- and model-based methods. Cost Effectiveness and Resource Allocation, 2015, (doi: 10.1186/s12962-015-0045-9)

Day, F. R. et al. (2015) Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility, and BRCA1-mediated DNA repair [editorial comment] Obstetrical and Gynecological Survey, 70, pp. 758-762. (doi: 10.1097/01.ogx.0000473766.71624.99)

Gao, H., Li, W.G., Cai, L., Berry, C., Luo, X.Y. (2015) Parameter estimation in a Holzapfel–Ogden law for healthy myocardium. Journal of Engineering Mathematics, 95, pp. 231-248. (doi: 10.1007/s10665-014-9740-3)

Artigas, M. S. et al. (2015) Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6, (doi: 10.1038/ncomms9658)

Williams, B., MacDonald, T. M., Morant, S., Webb, D. J., Sever, P., McInnes, G., Ford, I., Cruickshank, J. K., Caulfield, M. J., Salsbury, J., Mackenzie, I., Padmanabhan, S., Brown, M. J. (2015) Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. Lancet, 386, pp. 2059-2068. (doi: 10.1016/S0140-6736(15)00257-3)

Layland, J., Nerlekar, N., Palmer, S., Berry, C., Oldroyd, K. (2015) Invasive assessment of the coronary microcirculation in the catheter laboratory. International Journal of Cardiology, 199, pp. 141-149. (doi: 10.1016/j.ijcard.2015.05.190)

van Leeuwen, E. M. et al. (2015) Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C. npj Aging and Mechanisms of Disease, 1, (doi: 10.1038/npjamd.2015.11)

Aitken, E., Kerr, D., Geddes, C., Berry, C., Kingsmore, D. (2015) Cardiovascular changes occurring with occlusion of a mature arteriovenous fistula. Journal of Vascular Access, 16, pp. 459-466. (doi: 10.5301/jva.5000336)

Baillie, G. S. (2015) George Baillie on peptide array, a technique that transformed research on phosphodiesterases. Future Science OA, 1, (doi: 10.4155/fso.15.25)

Day, F. R. et al. (2015) Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genetics, 47, pp. 1294-1303. (doi: 10.1038/ng.3412)

Gong, Y., McDonough, C. W., Beitelshees, A. L., Rouby, N. E., Hiltunen, T. P., O’Connell, J. R., Padmanabhan, S., Langaee, T. Y., Hall, K., Schmidt, S. O.F., Curry, R. W., Gums, J. G., Donner, K. M., Kontula, K. K., Bailey, K. R., Boerwinkle, E., Takahashi, A., Tanaka, T., Kubo, M., Chapman, A. B., Turner, S. T., Pepine, C. J., Cooper-DeHoff, R. M., Johnson, J. A. (2015) PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. Journal of Hypertension, 33, pp. 2278-2285. (doi: 10.1097/hjh.0000000000000714)

MacLeod, R., Hillert, E.-K., Cameron, R. T., Baillie, G. S. (2015) The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease. Future Science OA, 1, (doi: 10.4155/fso.15.9)

Deng, L., Blanco Lopez, F. J., Stevens, H., Lu, R., Caudrillier, A., McBride, M., McClure, J. D., Grant, J., Thomas, M., Frid, M., Stenmark, K., White, K., Seto, A. G., Morrell, N. W., Bradshaw, A. C., MacLean, M. R., Baker, A. H. (2015) MicroRNA-143 activation regulates smooth muscle and endothelial cell crosstalk in pulmonary arterial hypertension. Circulation Research, 117, pp. 870-883. (doi: 10.1161/CIRCRESAHA.115.306806)

Patel, R., Jeemon, P., Stevens, K., Mccallum, L., Hastie, C., Schneider, A., Jardine, A., Mark, P., Padmanabhan, S. (2015) Association between serum phosphate and calcium, long-term blood pressure, and mortality in treated hypertensive adults. Journal of Hypertension, 33, pp. 2046-2053. (doi: 10.1097/hjh.0000000000000659)

Norrving, B., Bray, B. D., Asplund, K., Heuschmann, P., Langhorne, P., Rudd, A. G., Wagner, M., Wiedmann, S., Wolfe, C. D.A. (2015) Cross-national key performance measures of the quality of acute stroke care in Western Europe. Stroke, 46, pp. 2891-2895. (doi: 10.1161/strokeaha.115.008811)

Akehurst, C., Small, H., Sharafetdinova, L., Forrest, R., Beattie, W., Brown, C. E., Robinson, S. W., McClure, J. D., Work, L. M., Carty, D. M., McBride, M. W., Freeman, D. J., Delles, C. (2015) Differential expression of microRNA-206 and its target genes in pre-eclampsia. Journal of Hypertension, 33, pp. 2068-2074. (doi: 10.1097/HJH.0000000000000656)

Sin, Y. Y., Baillie, G. (2015) Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1) Cell Biochemistry and Function, 33, pp. 421-426. (doi: 10.1002/cbf.3147)

Zoccarato, A. et al. (2015) Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2. Circulation Research, 117, pp. 707-719. (doi: 10.1161/CIRCRESAHA.114.305892)

Corcoran, D., Grant, P., Berry, C. (2015) Risk stratification in non-ST elevation acute coronary syndromes: risk scores, biomarkers and clinical judgment. International Journal of Cardiology: Heart and Vasculature, 8, pp. 131-137. (doi: 10.1016/j.ijcha.2015.06.009)

Lindsey, M. L., Mayr, M., Gomes, A. V., Delles, C., Arrell, D. K., Murphy, A. M., Lange, R. A., Costello, C. E., Jin, Y.-F., Laskowitz, D. T., Sam, F., Terzic, A., Van Eyk, J., Srinivas, P. R. (2015) Transformative impact of proteomics on cardiovascular health and disease: a scientific statement from the American Heart Association. Circulation, 132, pp. 852-872. (doi: 10.1161/CIR.0000000000000226)

Mordi, I., Radjenovic, A., Stanton, T., Gardner, R., McPhaden, A., Carrick, D., Berry, C., Tzemos, N. (2015) Prevalence and prognostic significance of lipomatous metaplasia in poatients with prior myocardial infarction. JACC: Cardiovascular Imaging, 8, pp. 1111-1112. (doi: 10.1016/j.jcmg.2014.07.024)

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PGR

Emma Booth

  • Post Graduate Research Student
  • Research title: the role of IL-15 in vascular and cardiac fibrosis and remodelling 

Despite substantial progress in our knowledge and management of blood pressure, hypertension remains one of the most important modifiable cardiovascular risk factors. The importance of hypertension is such that in a national report the condition was named ‘Scotland’s Silent Killer’.

The University of Glasgow has a proud tradition of hypertension research, and this continues in the School of Cardiovascular and Metabolic Health. Our bench, to bedside, to population approach has resulted in a new understanding of the pathophysiology of hypertension and the identification of potential new targets for intervention. In our labs, we use techniques spanning from molecular biology and cellular assays to transgenic mouse models, myography, and blood pressure telemetry. While others in the team translate these findings to clinical trials and public health work.  

An exemplar of our approach can be seen in our aldosterone focused research. The hormone aldosterone is a key regulator of the cardiovascular system but its role as an important and treatable driver of hypertension has been poorly appreciated. By improving our understanding of how aldosterone production is regulated within the healthy human body and how this regulation can break down, we aim to improve diagnosis and treatment.

Our work goes beyond the laboratories and team members have had pivotal roles in creating clinical guidelines and raising standards in blood pressure assessment and treatment. There is still an enormous amount of work to do, as at presnet one-third of adults in Scotland have high blood pressure and only around one-quarter of these people are on adequate treatment. In addition to our science, we are actively involved in public engagement events with a focus on blood pressure management and lifestyle-based reductions.

Current areas:

  • Role of sodium and uromodulin in the pathogenesis of hypertension.
  • Asymmetric dimethylarginine (ADMA) is a risk factor and therapeutic target through its action on the nitric oxide synthase family of enzymes.
  • The use "omics" (proteomics, metabolomics, transcriptomics and epigenomics) AI (machine learning), systems biology and bioinformatics in the diagnosis of hypertension.
  • Laboratory-based analysis focused on a better understanding of the regulatory pathways that control aldosterone secretion by the adrenal cortex and its action on vascular cells.
  • Clinical trials that seek to explore how common genetic differences in the human population affect aldosterone production and predispose certain individuals to increased risk of hypertension.
  • Bioinformatic analysis of our data, using cutting-edge AI and pathway-based approaches to identify novel pathways and biomarkers for future research.
  • Hypertension and lifetime cardiovascular risk.