Research

Sin, Y. Y., Giblin, A., Judina, A., Rujirachaivej, P., Corral, L., Glennon, E., Tai, Z., Feng, T., Torres, E., Zorn, A., Gorelik, J., Kyurkchieva, E., Yenchitsomanus, P.-t., Swindlehurst, C., Chan, K., Stirling, D., Baillie, G. S. (2024) Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera. FEBS Journal, (doi: 10.1111/febs.17359)

Montezano, A. C., Kuriakose, J., Hood, K. Y., Sin, Y. Y., Camargo, L. L., Namkung, Y., Castro, C. H., Santos, R. A., Alves-Lopes, R., Tejeda, G., Passaglia, P., Basheer, S., Gallen, E., Findlay, J. E., Awan, F. R., Laporte, S. A., MacLean, M. R., Baillie, G. S., Touyz, R. M. (2024) Ang-(1-7) and ET-1 interplay through Mas and ETB receptor interaction defines a novel vasoprotective mechanism. Hypertension, (doi: 10.1161/HYPERTENSIONAHA.124.22693)

Hwej, A., Al-Ferjani, A., Alshuweishi, Y., Naji, A., Kennedy, S., Salt, I. (2024) Lack of AMP-activated protein kinase-α1 reduces nitric oxide synthesis in thoracic aorta perivascular adipose tissue. Vascular Pharmacology, 157, (doi: 10.1016/j.vph.2024.107437)

Fullerton, J. L., Hay, J., Bryant-Craig, C., Atkinson, J., Smith, D. H., Stewart, W. (2024) Pediatric traumatic brain injury and microvascular blood-brain barrier pathology. JAMA Network Open, 7, (doi: 10.1001/jamanetworkopen.2024.46767)

Main, A., Mary, S., Sin, Y. Y., Wright, T. A., Ling, J., Blair, C. M., Smith, G. L., Fuller, W., Baillie, G. S. (2024) SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline. International Journal of Biochemistry and Cell Biology, 176, (doi: 10.1016/j.biocel.2024.106668)

Riddell, A., Flynn, A., Bergugnat, H., Dowsett, L. B., Miller, A. A. (2024) SDMA as a marker and mediator in cerebrovascular disease. Clinical Science, 138, pp. 1305-1323. (doi: 10.1042/CS20241021)

Beazer, J. D., Sillars, A., Beck, S., Christoffersen, C., Ferraz, M. J., Mulder, M., Graham, D., Karlsson, H., Ljunggren, S. A., Gill, J. M. R., Freeman, D. J. (2024) Favourable HDL composition in endurance athletes is not associated with changes in HDL in vitro antioxidant and endothelial anti-inflammatory function. Bioscience Reports, (doi: 10.1042/BSR20241165)

Zhou, M., Mary, S., Delles, C., Padmanabhan, S., Graham, D., McBride, M. W., Dominiczak, A. (2024) Insights into uromodulin and blood pressure. Current Hypertension Reports, (doi: 10.1007/s11906-024-01317-0)

McNeilly, S. et al. (2024) Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage. EBioMedicine, 107, (doi: 10.1016/j.ebiom.2024.105315)

Lipina, T., Li, S., Petrova, E. S., Amstislavskaya, T. G., Cameron, R. T., Elliott, C., Gondo, Y., McGirr, A., Mullins, J. G.L., Baillie, G. S., Woodgett, J. R., Clapcote, S. J. (2024) PDE4B missense variant increases susceptibility to post-traumatic stress disorder-relevant phenotypes in mice. Journal of Neuroscience,

Koponen, M., Poyade, M., Daly, C. (2024) MyoSITE: A site-specific mixed reality educational tool for life sciences. Springer, Cham

McLaren, J., Gao, X., Ghouri, N., Freeman, D. J., Richardson, J., Sattar, N., Gill, J. M.R. (2024) Weight gain leads to greater adverse metabolic responses in South Asian compared with white European men: the GlasVEGAS study. Nature Metabolism, 6, pp. 1632-1645. (doi: 10.1038/s42255-024-01101-z)

Thongyim, S., Wright, T. A., Sattayawat, P., Kaewkod, T., Baillie, G. S., Tragoolpua, Y., Jangsutthivorawat, S., Panya, A. (2024) Clinacanthus nutans extract lowers periodontal inflammation under high-glucose conditions via inhibiting NF-κB signaling pathway. Frontiers in Pharmacology, 15, (doi: 10.3389/fphar.2024.1410419)

Schofield, C., Sarrigiannidis, S., Moran-Horowich, A., Jackson, E., Rodrigo-Navarro, A., Van Agtmael, T., Cantini, M., Dalby, M. J., Salmeron-Sanchez, M. (2024) An in vitro model of the blood-brain barrier for the investigation and isolation of the key drivers of barriergenesis. Advanced Healthcare Materials, (doi: 10.1002/adhm.202303777)

Sin, Y. Y., Cameron, R. T., Schepers, M., MacLeod, R., Wright, T. A., Paes, D., van den Hove, D., Willems, E., Vanmierlo, T., Prickaerts, J., Blair, C. M., Baillie, G. S. (2024) Beta-amyloid interacts with and activates the longform phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability. FEBS Letters, 598, pp. 1591-1604. (doi: 10.1002/1873-3468.14902)

Shead, K. D., Salyahetdinova, V., Baillie, G. S. (2024) Charting the importance of Filamin A posttranslational modifications. Biochemical Journal, 481, pp. 865-881. (doi: 10.1042/BCJ20240121)

Gardner, O. F.W., Bai, T., Baillie, G. S., Ferretti, P. (2024) Phosphodiesterase 4D activity in acrodysostosis-associated neural pathology: too much or too little? Brain Communications, (doi: 10.1093/braincomms/fcae225)

Ramses, R., Kennedy, S., Good, R., Oldroyd, K. G., Mcginty, S. (2024) Performance of drug-coated balloons in coronary and below-the-knee arteries: anatomical, physiological and pathological considerations. Vascular Pharmacology, 155, (doi: 10.1016/j.vph.2024.107366)

Loughrey, C. et al. (2024) A novel ryanodine receptor 2 inhibitor, M201-A, enhances natriuresis, renal function and lusi-inotropic action: Pre-clinical and phase I study. British Journal of Pharmacology, 181, pp. 3401-3419. (doi: 10.1111/bph.16379)

Olivera, S., Graham, D. (2024) Modelling pre-eclampsia and its cardiovascular effects. Nature Reviews Cardiology, 21, (doi: 10.1038/s41569-024-01006-0)

Cooke, S. F., Wright, T. A., Sin, Y. Y., Ling, J., Kyurkchieva, E., Phanthaphol, N., McSkimming, T., Herbert, K., Rebus, S., Biankin, A. V., Chang, D. K., Baillie, G. S., Blair, C. M. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, (doi: 10.1038/s41598-024-59451-3)

Gulliver, C., Busiau, T., Byrne, A., Findlay, J. E., Hoffmann, R., Baillie, G. (2024) cAMP-phosphodiesterase 4D7 (PDE4D7) forms a cAMP signalosome complex with DHX9 and is implicated in prostate cancer progression. Molecular Oncology, 18, pp. 707-725. (doi: 10.1002/1878-0261.13572)

Hoare, D., Kingsmore, D., Holsgrove, M., Russell, E., Kirimi, M. T., Czyzewski, J., Mirzai, N., Kennedy, S., Neale, S. L., Mercer, J. R. (2024) Realtime monitoring of thrombus formation in vivo using a self-reporting vascular access graft. Communications Medicine, 4, (doi: 10.1038/s43856-024-00436-8)

Mary, S., Conti-Ramsden, F., Boder, P., Parveen, H., Setjiadi, D., Fleminger, J., Brockbank, A., Graham, D., Bramham, K., Chappell, L. C., Delles, C. (2024) Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension. Journal of Nephrology, (doi: 10.1007/s40620-023-01830-6)

Lyon, M., Fullerton, J. L., Kennedy, S., Work, L. M. (2024) Hypertension & dementia: pathophysiology & potential utility of antihypertensives in reducing disease burden. Pharmacology and Therapeutics, 253, (doi: 10.1016/j.pharmthera.2023.108575)

McFall, A., Graham, D., Nicklin, S. A., Work, L. M. (2024) Unscheduled changes in pre-clinical stroke model housing contributes to variance in physiological and behavioural data outcomes: a post hoc analysis. Brain and Neuroscience Advances, 8, (doi: 10.1177/23982128241238934)

Freeman-Jones, E., Miller, W. H., Work, L. M., Fullerton, J. L. (2023) Polypathologies and animal models of traumatic brain injury. Brain Sciences, 13, (doi: 10.3390/brainsci13121709)

Fullerton, J. L., Cosgrove, C. C., Rooney, R. A., Work, L. (2023) Extracellular vesicles and their microRNA cargo in ischaemic stroke. Journal of Physiology, 601, pp. 4907-4921. (doi: 10.1113/JP282050)

Martin, T. P., MacDonald, E. A., Bradley, A., Watson, H., Saxena, P., Rog-Zielinska, E. A., Raheem, A., Fisher, S., Elbassioni, A. A. M., Almuzaini, O., Booth, C., Campbell, M., Riddell, A., Herzyk, P., Blyth, K., Nixon, C., Zentilin, L., Berry, C., Braun, T., Giacca, M., McBride, M. W., Nicklin, S. R., Cameron, E. R., Loughrey, C. (2023) Ribonucleicacid interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction. Cardiovascular Research, 119, pp. 2663–2671-2663–2671. (doi: 10.1093/cvr/cvad107)

Irshad, Z., Lund, J., Sillars, A., Løvsletten, N. G., Gharanei, S., Salt, I. P., Freeman, D. J., Gill, J. M.R., Thoresen, G. H., Rustan, A. C., Zammit, V. A. (2023) The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background. FASEB Journal, 37, (doi: 10.1096/fj.202300960RR)

Gulliver, C., Huss, S., Semjonow, A., Baillie, G. S., Hoffmann, R. (2023) Loss of PDE4D7 expression promotes androgen independence, neuroendocrine differentiation, and alterations in DNA repair: implications for therapeutic strategies. British Journal of Cancer, 129, pp. 1462-1476. (doi: 10.1038/s41416-023-02417-5)

Gulliver, C., Baillie, G. S., Hoffmann, R. (2023) Reduced PDE4D7 in prostate cancer correlates with genomic downregulation within the upstream PDE4D coding region. Future Science OA, 9, (doi: 10.2144/fsoa-2023-0064)

Parsons, E. C., Baillie, G. S., Hoffmann, R. (2023) Revisiting the roles of cAMP signalling in the progression of prostate cancer. Biochemical Journal, 480, pp. 1599-1614. (doi: 10.1042/BCJ20230297)

Brown, A. D., Vergunst, K. L., Branch, M., Blair, C. M., Dupré, D. J., Baillie, G. S., Langelaan, D. N. (2023) Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor. Biochimica et Biophysica Acta: Molecular Cell Research, 1870, (doi: 10.1016/j.bbamcr.2023.119520)

Meyer, B. J., Cortie, C., Dekker-Nitert, M., Barrett, H. L., Freeman, D. J. (2023) Women with gestational diabetes mellitus, controlled for plasma glucose level, exhibit maternal and fetal dyslipidaemia that may warrant treatment. Diabetes Research and Clinical Practice, 204, (doi: 10.1016/j.diabres.2023.110929)

Cui, L., Yang, B., Xiao, S., Gao, J., Baud, A., Graham, D., McBride, M., Dominiczak, A., Schafer, S., Aumatell, R. L., Mont, C., Teruel, A. F., Hübner, N., Flint, J., Mott, R., Huang, L. (2023) Dominance is common in mammals and is associated with trans-acting gene expression and alternative splicing. Genome Biology, 24, (doi: 10.1186/s13059-023-03060-2)

Wright, T. A., Gemmell, A. O., Tejeda, G. S., Blair, C. M., Baillie, G. S. (2023) Cancer: phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target. International Journal of Biochemistry and Cell Biology, 162, (doi: 10.1016/j.biocel.2023.106453)

Zorn, A., Baillie, G. (2023) Phosphodiesterase 7 as a therapeutic target – Where are we now? Cellular Signalling, 108, (doi: 10.1016/j.cellsig.2023.110689)

Olivera, S., Graham, D. (2023) Sex differences in preclinical models of hypertension. Journal of Human Hypertension, 37, pp. 619-625. (doi: 10.1038/s41371-022-00770-1)

Paes, D., Schepers, M., Willems, E., Rombaut, B., Tiane, A., Solomina, Y., Tibbo, A., Blair, C., Kyurkchieva, E., Baillie, G. S., Ricciarelli, R., Brullo, C., Fedele, E., Bruno, O., van den Hove, D., Vanmierlo, T., Prickaerts, J. (2023) Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology. Cellular and Molecular Life Sciences, 80, (doi: 10.1007/s00018-023-04804-w)

Dowsett, L., Duluc, L., Higgins, E., Alghamdi, F., Fast, W., Salt, I. P., Leiper, J. (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular Signalling, 107, (doi: 10.1016/j.cellsig.2023.110676)

Kyurkchieva, E., Baillie, G. S. (2023) Short PDE4 isoforms as drug targets in disease. Frontiers in Bioscience: Landmark, 28, (doi: 10.31083/j.fbl2807133)

Fullerton, J., Bettencourt, C., Daniels, M., Mclean, F., Simpson, S., Smith, A., Woodling, N., Kerr, F. (2023) Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field. Health Open Research, 4, (doi: 10.12688/amrcopenres.13091.2)

Gulliver, C., Huss, S., Semjonow, A., Baillie, G. S., Hoffmann, R. (2023) The CAPRA&PDE4D5/7/9 prognostic model is significantly associated to adverse post-surgical pathology outcomes. Cancers, 15, (doi: 10.3390/cancers15010262)

Gerganova, G., Riddell, A., Miller, A. A. (2022) CNS border-associated macrophages in the homeostatic and ischaemic brain. Pharmacology and Therapeutics, 240, (doi: 10.1016/j.pharmthera.2022.108220)

Kumar, A. A., Yeo, N., Whittaker, M., Attra, P., Barrick, T. R., Bridges, L. R., Dickson, D. W., Esiri, M. M., Farris, C. W., Graham, D., Lin, W. L., Meijles, D. N., Pereira, A. C., Perry, G., Rosene, D. L., Shtaya, A. B., Van Agtmael, T., Zamboni, G., Hainsworth, A. H. (2022) Vascular collagen type-IV in hypertension and cerebral small vessel disease. Stroke, 53, pp. 3696-3705. (doi: 10.1161/STROKEAHA.122.037761)

Mary, S., Boder, P., Padmanabhan, S., McBride, M. W., Graham, D., Delles, C., Dominiczak, A. F. (2022) The role of uromodulin in salt-sensitive hypertension. Hypertension, 79, pp. 2419-2429. (doi: 10.1161/HYPERTENSIONAHA.122.19888)

Main, A., Bogusalvskyii, A., Howie, J., Kuo, C.-W., Rankin, A., Burton, F. L., Smith, G. L., Hajjar, R., Baillie, G. S., Campbell, K. S., Shattock, M. J., Fuller, W. (2022) Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies. Frontiers in Physiology, 13, (doi: 10.3389/fphys.2022.1023237)

Reel, P. S. et al. (2022) Machine learning for classification of hypertension subtypes using multi-omics: a multi-centre, retrospective, data-driven study. EBioMedicine, 84, (doi: 10.1016/j.ebiom.2022.104276)

Fertig, B., Ling, J., Nollet, E. E., Dobi, S., Busiau, T., Ishikawa, K., Yamada, K., Lee, A., Kho, C., Wills, L., Tibbo, A. J., Scott, M., Grant, K., Campbell, K. S., Birks, E. J., MacQuaide, N., Hajjar, R., Smith, G. L., van der Velden, J., Baillie, G. (2022) SUMOylation does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca2+ FEBS Journal, 289, pp. 6267-6285. (doi: 10.1111/febs.16537)

McQueen, A., Escuer, J., Schmidt, A. F., Aggarwal, A., Kennedy, S., McCormick, C., Oldroyd, K., Mcginty, S. (2022) An intricate interplay between stent drug dose and release rate dictates arterial restenosis. Journal of Controlled Release, 349, pp. 992-1008. (doi: 10.1016/j.jconrel.2022.07.037)

Daly, C., Briddon, S. (2022) Pharmacology in the Metaverse. Pharmacology Matters, 2022,

Stathopoulou, K., Schnittger, J., Raabe, J., Fleischer, F., Mangels, N., Piasecki, A., Findlay, J., Hartmann, K., Krasemann, S., Schlossarek, S., Uebeler, J., Wixler, V., Blake, D. J., Baillie, G., Carrier, L., Ehler, E., Cuello, F. (2022) CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes. FEBS Journal, 289, pp. 4622-4645. (doi: 10.1111/febs.16402)

Gulliver, C., Hoffmann, R., Baillie, G. S. (2022) Ataxia-telangiectasia mutated and ataxia telangiectasia and Rad3-related kinases as therapeutic targets and stratification indicators for prostate cancer. International Journal of Biochemistry and Cell Biology, 147, (doi: 10.1016/j.biocel.2022.106230)

Fullerton, J. L., Thomas, J. M., Gonzalez-Trueba, L., Trivett, C., Van Kralingen, J. C., Allan, S. M., Quinn, T. J., Work, L. M. (2022) Systematic review: association between circulating microRNA expression & stroke. Journal of Cerebral Blood Flow and Metabolism, 42, pp. 935-951. (doi: 10.1177/0271678X221085090)

Beazer, J. D., Freeman, D. J. (2022) Estradiol and HDL function in women – a partnership for life. Journal of Clinical Endocrinology and Metabolism, 107, pp. e2192-2194. (doi: 10.1210/clinem/dgab811)

He, W. et al. (2022) Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size. Cardiovascular Research, 118, pp. 1535-1547. (doi: 10.1093/cvr/cvab204)

Malfait, F., Forlino, A., Sengle, G., Van Agtmael, T. (2022) Editorial: molecular mechanisms of heritable connective tissue disorders. Frontiers in Genetics, 13, (doi: 10.3389/fgene.2022.866665)

Tibbo, A. J., Mika, D., Dobi, S., Ling, J., McFall, A., Tejeda, G. S., Blair, C., MacLeod, R., MacQuaide, N., Gök, C., Fuller, W., Smith, B. O., Smith, G. L., Vandecasteele, G., Brand, T., Baillie, G. S. (2022) Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins. Journal of Molecular and Cellular Cardiology, 165, pp. 86-102. (doi: 10.1016/j.yjmcc.2022.01.001)

Dritsoula, A., Dowsett, L., Pilotti, C., O'Connor, M. N., Moss, S. E., Greenwood, J. (2022) Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway. Scientific Reports, 12, (doi: 10.1038/s41598-022-08516-2)

Martin, T. P., MacDonald, E. A., Elbassioni, A. A., Zaeri, A. A. I., O'Toole, D., Nicklin, S. A., Gray, G. A., Loughrey, C. M. (2022) Pre-clinical models of myocardial infarction: from mechanism to translation. British Journal of Pharmacology, 179, pp. 770-791. (doi: 10.1111/bph.15595)

Stoyek, M. R., MacDonald, E., Mantifel, M., Baillie, J. S., Selig, B. M., Croll, R. P., Smith, F. M., Quinn, T. A. (2022) Drivers of sinoatrial node automaticity in zebrafish: comparison with mechanisms of mammalian pacemaker function. Frontiers in Physiology, 13, (doi: 10.3389/fphys.2022.818122)

Bakalchuk, S., Walker, C., Daly, C., Hill, L., Poyade, M. (2022) Creating interactive three-dimensional applications to visualise novel stent grafts that aid in the treatment of aortic aneurysms. Springer

Douglass, A., Moffat, G., Daly, C. (2022) Using confocal microscopy to generate an accurate vascular model for use in patient education animation. Springer

Baillie, G., Kyurkchieva, E., Sin, Y. Y., Ahmed, F., Rajapakse, N., Schoolmeesters, A., Richard, N., Erdman, P., Hecht, D., Chourasia, A. H., Mercurio, F., Fung, L., Chan, K., Stirling, D. (2022) Evaluating the Utility of Bi-functional Degrader Molecules for Selective Inhibition of PDE4 In Acrodysostosis Type2.

Trivett, C., Lees, Z. J., Freeman, D. J. (2021) Adipose tissue function in healthy pregnancy, gestational diabetes mellitus and pre-eclampsia. European Journal of Clinical Nutrition, 75, pp. 1745-1756. (doi: 10.1038/s41430-021-00948-9)

Omar, R., Malfait, F., Van Agtmael, T. (2021) Four decades in the making: collagen III and mechanisms of vascular Ehlers Danlos Syndrome. Matrix Biology Plus, 12, (doi: 10.1016/j.mbplus.2021.100090)

Alsufyani, H. A., Daly, C., Docherty, J. R. (2021) Interaction between α 1B ‐ and other α 1 ‐ and α 2 ‐adrenoceptors in producing contractions of mouse spleen. Basic and Clinical Pharmacology and Toxicology, 129, pp. 416-426. (doi: 10.1111/bcpt.13639)

Mary, S., Boder, P., Rossitto, G., Graham, L., Scott, K., Flynn, A., Kipgen, D., Graham, D., Delles, C. (2021) Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats. Clinical Science, 135, pp. 2749-2761. (doi: 10.1042/CS20211017)

Mahindra, A., Tejeda, G., Rossi, M., Janha, O., Herbert, I., Morris, C., Morgan, D. C., Beattie, W., Montezano, A. C., Hudson, B., Tobin, A. B., Bhella, D., Touyz, R. M., Jamieson, A. G., Baillie, G. S., Blair, C. M. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16, (doi: 10.1371/journal.pone.0260283)

O'Connor, M. N., Kallenberg, D. M., Camilli, C., Pilotti, C., Dritsoula, A., Jackstadt, R., Bowers, C. E., Watson, H. A., Alatsatianos, M., Ohme, J., Dowsett, L., George, J., Blackburn, J. W.D., Wang, X., Singhal, M., Augustin, H. G., Ager, A., Sansom, O. J., Moss, S. E., Greenwood, J. (2021) LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency. Med, 2, pp. 1231-1252.e10. (doi: 10.1016/j.medj.2021.10.002)

MacKenzie, S. M., Saunders, H., van Kralingen, J. C., Robertson, S., Riddell, A., Zennaro, M.-C., Davies, E. (2021) Circulating microRNAs as diagnostic markers in primary aldosteronism. Cancers, 13, (doi: 10.3390/cancers13215312)

MacDonald, E. A., Quinn, T. A. (2021) What keeps us ticking? Sinoatrial node mechano-sensitivity: the grandfather clock of cardiac rhythm. Biophysical Reviews, 13, pp. 707-716. (doi: 10.1007/s12551-021-00831-8)

Pokhilko, A., Brezzo, G., Handunnetthi, L., Heilig, R., Lennon, R., Smith, C., Allan, S. M., Granata, A., Sinha, S., Wang, T., Markus, H. S., Naba, A., Fischer, R., Van Agtmael, T., Horsburgh, K., Cader, M. Z. (2021) Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease. Journal of Cerebral Blood Flow and Metabolism, 41, pp. 2423-2438. (doi: 10.1177/0271678X211004307)

Buist, H. K., Luchowska-Stańska, U., van Basten, B., Valli, J., Smith, B. O., Baillie, G. S., Rickman, C., Ricketts, B., Davidson, A., Hannam, R., Sunderland, J., Yarwood, S. J. (2021) Identification and characterization of an affimer affinity reagent for the detection of the cAMP sensor, EPAC1. Cells, 10, (doi: 10.3390/cells10092307)

Alves-Lopes, R., Montezano, A. C., Neves, K. B., Harvey, A., Rios, F. J., Skiba, D. S., Arendse, L. B., Guzik, T. J., Graham, D., Poglitsch, M., Sturrock, E., Touyz, R. M. (2021) Selective inhibition of the C-domain of ACE (angiotensin-converting enzyme) combined with inhibition of NEP (neprilysin): a potential new therapy for hypertension. Hypertension, 78, pp. 604-616. (doi: 10.1161/HYPERTENSIONAHA.121.17041)

Patanapirunhakit, P., Karlsson, H., Mulder, M., Ljunggren, S., Graham, D., Freeman, D. (2021) Sphingolipids in HDL – potential markers for adaptation to pregnancy? Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids, 1866, (doi: 10.1016/j.bbalip.2021.158955)

Boland, E., Quondamatteo, F., Van Agtmael, T. (2021) The role of basement membranes in cardiac biology and disease. Bioscience Reports, 41, pp. BSR20204185. (doi: 10.1042/bsr20204185)

Chung, J. et al. (2021) Rare missense functional variants at COL4A1 and COL4A2 in sporadic intracerebral hemorrhage. Neurology, 97, pp. e236-e247. (doi: 10.1212/WNL.0000000000012227)

Randles, M., Lausecker, F., Kong, Q., Suleiman, H., Reid, G., Kolatsi-Joannou, M., Tian, P., Falcone, S., Davenport, B., Potter, P., Van Agtmael, T., Norman, J., Long, D., Humphries, M., Miner, J., Lennon, R. (2021) Identification of an altered matrix signature in kidney aging and disease. Journal of the American Society of Nephrology, 32, pp. 1713-1732. (doi: 10.1681/ASN.2020101442)

Morgan, D. C., Morris, C., Mahindra, A., Blair, C. M., Tejeda, G., Herbert, I., Turnbull, M. L., Lieber, G., Willett, B. J., Logan, N., Smith, B., Tobin, A. B., Bhella, D., Baillie, G. S., Jamieson, A. G. (2021) Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalisation. Peptide Science, 113, (doi: 10.1002/pep2.24217)

Reuten, R. et al. (2021) Basement membrane stiffness determines metastases formation. Nature Materials, 20, pp. 892-903. (doi: 10.1038/s41563-020-00894-0)

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Omar, F., Findlay, J. E., Carfray, G., Allcock, R. W., Jiang, Z., Moore, C., Muir, A. L., Lannoy, M., Fertig, B. A., Maie, D., Day, J. P., Bolger, G., Baillie, G. S., Schwiebert, E., Klussmann, E., Pyne, N. J., Ong, A. C.M., Bowers, K., Adam, J. M., Adams, D. R., Houslay, M. D., Hendersona, D. J.P. (2019) Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proceedings of the National Academy of Sciences of the United States of America, 116, pp. 13320-13329. (doi: 10.1073/pnas.1822113116)

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Clister, T., Greenwald, E. C., Baillie, G. S., Zhang, J. (2019) AKAP95 organizes a nuclear microdomain to control local cAMP for regulating nuclear PKA. Cell Chemical Biology, 26, pp. 885-891. (doi: 10.1016/j.chembiol.2019.03.003)

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Daly, C. J. (2019) From confocal microscope to virtual reality and computer games; technical and educational considerations. Infocus Magazine, 54, pp. 51-59.

Kinch, K., Fullerton, J. L., Stewart, W. (2019) One-hundred years (and counting) of blast-associated traumatic brain injury. Journal of the Royal Army Medical Corps, 165, pp. 180-182. (doi: 10.1136/jramc-2017-000867)

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Vagena, E., Ryu, J. K., Baeza-Raja, B., Walsh, N. M., Syme, C., Day, J. P., Houslay, M., Baillie, G. (2019) A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signalling. Translational Psychiatry, 9, (doi: 10.1038/s41398-019-0470-1)

Olson, E., Pravenec, M., Landa, V., Koh-Tan, H. H. C., Dominiczak, A. F., McBride, M. W., Graham, D. (2019) Transgenic overexpression of glutathione S-transferase μ-type 1 reduces hypertension and oxidative stress in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 37, pp. 985-996. (doi: 10.1097/HJH.0000000000001960)

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Jones, F. E., Murray, L. S., McNeilly, S., Dean, A., Aman, A., Lu, Y., Nikolova, N., Malomgre, R., Horsburgh, K., Holmes, W. M., Kadler, K. E., Van Agtmael, T. (2019) 4-Sodium phenyl butyric acid has both efficacy and counter-indicative effects in the treatment of Col4a1 disease. Human Molecular Genetics, 28, pp. 628-638. (doi: 10.1093/hmg/ddy369)

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Kennedy, S., Touyz, R. M. (2019) Anatomy and pharmacology of vessels. Springer

Daly, C. J. (2019) Autonomic innervation of visceral and peri-vascular adipose tissue. Editora UFPE

Daly, C. J. (2019) Examining vascular structure and function using confocal microscopy and 3D imaging techniques. Springer

Daly, C. J. (2019) Imaging the vascular wall: from microscope to virtual reality. Springer

Tibbo, A. J., Busiau, T., Baillie, G. S. (2019) Methods to investigate arrestins in complex with phosphodiesterases. Springer

Logue, J., Sattar, N., Freeman, D. (2019) Obesity. Springer

Blair, C. M., Walsh, N., Littman, B. H., Marcoux, F. W., Baillie, G. S. (2019) Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A – C-Raf. BMC Cancer, 19, (doi: 10.1186/s12885-019-5489-4)

Graham, D. (2019) Vascular physiology. Springer

Strembitska, A., Mancini, S. J., Gamwell, J. M., Palmer, T. M., Baillie, G. S., Salt, I. P. (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase. International Journal of Molecular Sciences, 19, (doi: 10.3390/ijms19123886)

Maziarz, M., Broselid, S., DiGiacomo, V., Park, J.-C., Luebbers, A., Garcia-Navarrete, L., Blanco-Canosa, J. B., Baillie, G. S., Garcia-Marcos, M. (2018) A biochemical and genetic discovery pipeline identifies PLCδ4b as a non-receptor activator of heterotrimeric G proteins. Journal of Biological Chemistry, 293, pp. 16964-16983. (doi: 10.1074/jbc.RA118.003580)

MacDonald, E., Quinn, T. A. (2018) Mechanical Determinants of the Chronotropic Response to Sinoatrial Stretch. (doi: 10.1016/j.yjmcc.2018.07.030)

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Elliott, C., Rojo, A. I., Ribe, E., Broadstock, M., Xia, W., Morin, P., Semenov, M., Baillie, G., Cuadrado, A., Al-Shawi, R., Ballard, C. G., Simons, P., Killick, R. (2018) A role for APP in Wnt signalling links synapse loss with β-amyloid production. Translational Psychiatry, 8, (doi: 10.1038/s41398-018-0231-6)

Engelhardt, B., Holze, J., Elliott, C., Baillie, G.S., Kschischo, M., Fröhlich, H. (2018) Modelling and mathematical analysis of the M2 receptor-dependent joint signalling and secondary messenger network in CHO cells. Mathematical Medicine and Biology, 35, pp. 279-297. (doi: 10.1093/imammb/dqx003)

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Daly, J. P., Whiteley, E., Freeley, M., Long, A., Malacrida, B., Kiely, P., Baillie, G. S. (2018) RAB40C regulates RACK1 stability via the ubiquitin-proteasome system. Future Science OA, 4, (doi: 10.4155/fsoa-2018-0022)

van Strijp, D., de Witz, C., Vos, P. C., den Biezen, E., van Brussel, A., Wrobel, J., Baillie, G. S., Tennstedt, P., Schlomm, T., Heitkötter, B., Huss, S., Bögemann, M., Houslay, M. D., Bangma, C. H., Semjonow, A., Hoffmann, R. (2018) The prognostic PDE4D7 score in a diagnostic biopsy prostate cancer patient cohort with longitudinal biological outcomes. Prostate Cancer, 2018, (doi: 10.1155/2018/5821616)

Rajani, R. M., Quick, S., Ruigrok, S. R., Graham, D., Harris, S. E., Verhaaren, B. F.J., Fornage, M., Seshadri, S., Atanur, S. S., Dominiczak, A. F., Smith, C., Wardlaw, J. M., Williams, A. (2018) Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Science Translational Medicine, 10, (doi: 10.1126/scitranslmed.aam9507)

Daly, C. J. (2018) The future of education? Using 3D animation and virtual reality in teaching physiology. Physiology News, 111, pp. 43.

Morgan, H. L., Butler, E., Ritchie, S., Herse, F., Dechend, R., Beattie, E., McBride, M. W., Graham, D. (2018) Modeling superimposed preeclampsia using Ang II (Angiotensin II) infusion in pregnant stroke-prone spontaneously hypertensive rats. Hypertension, 72, pp. 208-218. (doi: 10.1161/HYPERTENSIONAHA.118.10935)

De Lucca Camargo, L., Harvey, A. P., Rios, F. J., Tsiropoulou, S., Silva, R. D. N. d. O., Cao, Z., Graham, D., McMaster, C., Burchmore, R. J., Hartley, R. C., Bulleid, N., Montezano, A. C., Touyz, R. M. (2018) Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72, pp. 235-246. (doi: 10.1161/HYPERTENSIONAHA.118.10824)

Bailey, E., McBride, M. W., McClure, J. D., Beattie, W., Graham, D., Dominiczak, A., Smith, C., Wardlaw, J. (2018) Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease. Clinical Science, 132, pp. 1315-1328. (doi: 10.1042/CS20171572)

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Armfield, K., Baillie, G., Wilson, J.B. (2018) Development of Therapeutic Approaches to Targeting Epstein-Barr virus Related Malignancies.

de Inda, M. A., van Strijp, D., den Biezen-Timmermans, E., van Brussel, A., Wrobel, J., van Zon, H., Vos, P., Baillie, G. S., Tennstedt, P., Schlomm, T., Houslay, M. D., Bangma, C., Hoffmann, R. (2018) Validation of cyclic adenosine monophosphate phosphodiesterase-4D7 for its independent contribution to risk stratification in a prostate cancer patient cohort with longitudinal biological outcomes. European Urology Focus, 4, pp. 376-384. (doi: 10.1016/j.euf.2017.05.010)

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