Machine Learning
Machine Learning (ML), also known as Artificial Intelligence (AI), is the use of computer algorithms to find and extract patterns in large data sets and using these patterns to predict outcomes.
Staff
Publications
2024
Rochmawati, I. D., Deo, S., Lees, J. S., Mark, P. B., Sattar, N., Celis-Morales, C., Pell, J. P., Welsh, P., Ho, F. K. (2024) Adding traditional and emerging biomarkers for risk assessment in secondary prevention: a prospective cohort study of 20,656 patients with cardiovascular disease. European Journal of Preventive Cardiology, (doi: 10.1093/eurjpc/zwae352)
Liu, Q., Celis-Morales, C., Lees, J. S., Sattar, N., Ho, F., Pell, J. P., Mark, P. B., Welsh, P. (2024) Change in physical activity and its association with decline in kidney function: A UK Biobank-based cohort study. Journal of Cachexia, Sarcopenia and Muscle, 15, pp. 2046-2055. (doi: 10.1002/jcsm.13551)
Marshall, W. R., Curran, G. A., Traynor, J. P., Gillis, K. A., Mark, P. B., Lees, J. S. (2024) Sodium zirconium cyclosilicate treatment and rates of emergency interventions for hyperkalaemia: a propensity-score weighted case-control study. Clinical Kidney Journal, (doi: 10.1093/ckj/sfae313)
Greiffenhagen, L., Kutti, T., Maier, S. R., De Clippele, L. (2024) Biomass mapping of fjordic cold-water coral reefs reveals distinct functional role of vertical wall habitat. Deep Sea Research Part I: Oceanographic Research Papers, 211, (doi: 10.1016/j.dsr.2024.104350)
Elyan, B. M.P., Sullivan, M. K., Hedley, J., De La Mata, N., Webster, A. C., Venugopal, B., Jones, R. J., Lang, N. N., Mark, P. B., Lees, J. S. (2024) The impact of VEGF signalling pathway inhibitors and/or immune checkpoint inhibitors on kidney function over time: a single centre retrospective analysis. BJC Reports, 2, (doi: 10.1038/s44276-024-00081-7)
Sullivan, M. K., Lees, J. S., Rosales, B. M., Cutting, R., Wyld, M. L., Woodward, M., Webster, A. C., Mark, P. B., De La Mata, N. (2024) Sex and the relationship between cardiometabolic risk factors and estimated GFR Decline: a population-based cohort study. American Journal of Kidney Diseases, (doi: 10.1053/j.ajkd.2024.05.007)
Clark, H. P., Smith, A. G., McKay Fletcher, D., Larsson, A. I., Jaspars, M., De Clippele, L. H. (2024) New interactive machine learning tool for marine image analysis. Royal Society Open Science, 11, (doi: 10.1098/rsos.231678)
Mayne, K. J., Hanlon, P., Lees, J. S. (2024) Detecting and managing the patient with chronic kidney disease in primary care: A review of the latest guidelines. Diabetes, Obesity and Metabolism, (doi: 10.1111/dom.15625)
Lees, J. S., Crowther, J., Hanlon, P., Butterly, E., Wild, S. H., Mair, F. S., Guthrie, B., Gillies, K., Dias, S., Welton, N. J., Katikireddi, S. V., McAllister, D. A. (2024) Participant characteristics and exclusion from trials: a meta-analysis of individual participant-level data from phase 3/4 industry-funded trials in chronic medical conditions. BMJ Medicine, 3, (doi: 10.1136/bmjmed-2023-000732)
Lees, J. S., Fabian, J., Shlipak, M. G. (2024) Cystatin C should be routinely available for estimating kidney function. Current Opinion in Nephrology and Hypertension, 33, pp. 337-343. (doi: 10.1097/MNH.0000000000000980)
Rankin, S., Elyan, B., Jones, R., Venugopal, B., Mark, P. B., Lees, J. S., Petrie, M. C., Lang, N. N. (2024) Cardiovascular eligibility criteria and adverse event reporting in combined immune checkpoint and VEGF inhibitors trials. JACC: CardioOncology, 6, pp. 267-279. (doi: 10.1016/j.jaccao.2023.12.010)
Chen, D. C., Lu, K., Scherzer, R., Lees, J. S., Rutherford, E., Mark, P. B., Potok, O. A., Rifkin, D. E., Ix, J. H., Shlipak, M. G., Estrella, M. M. (2024) Cystatin C- and creatinine-based estimated GFR differences: prevalence and predictors in the UK Biobank. Kidney Medicine, 6, (doi: 10.1016/j.xkme.2024.100796)
Shemilt, R., Sullivan, M.K., Hanlon, P., Jani, B., De La Mata, N., Rosales, B., Elyan, B.M.P., Hedley, J.A., Cutting, R.B., Wyld, M., McAllister, D.A., Webster, A.C., Mark, P.B., Lees, J.S. (2024) Sex differences in cancer outcomes across the range of eGFR. Nephrology Dialysis Transplantation, (doi: 10.1093/ndt/gfae059)
2023
Mayne, K. J. et al. (2023) Effects of empagliflozin on fluid overload, weight and blood pressure in chronic kidney disease. Journal of the American Society of Nephrology, (doi: 10.1681/ASN.0000000000000271)
Asa Strong, J., Piechaud, N., De Clippele, L. H., Bett, B. J., Horton, T., Corbera, G., Huvenne, V. A. I. (2023) Recovery and restoration potential of cold‐water corals: experience from a deep‐sea marine protected area. Restoration Ecology, 31, (doi: 10.1111/rec.13970)
Jani, B. D., Sullivan, M. K., Hanlon, P., Nicholl, B. I., Lees, J. S., Brown, L., MacDonald, S., Mark, P. B., Mair, F. S., Sullivan, F. M. (2023) Personalised lung cancer risk stratification and lung cancer screening: do general practice electronic medical records have a role? British Journal of Cancer, (doi: 10.1038/s41416-023-02467-9)
Radley, A., Lees, J. S., Stevens, K. I. (2023) Cardiovascular disease in older women with CKD. Clinical Kidney Journal, 16, pp. 2304-2308. (doi: 10.1093/ckj/sfad235)
Lees, J. S., Mark, P. B. (2023) GFR slope as a surrogate marker for future kidney failure. Nature Reviews Nephrology, 19, pp. 625-626. (doi: 10.1038/s41581-023-00748-3)
Maier, S. R., Brooke, S., De Clippele, L. H., de Froe, E., van der Kaaden, A.‐S., Kutti, T., Mienis, F., van Oevelen, D. (2023) On the paradox of thriving cold‐water coral reefs in the food‐limited deep sea. Biological Reviews, 98, pp. 1768-1795. (doi: 10.1111/brv.12976)
van der Kaaden, A.-S., Maier, S. R., Siteur, K., De Clippele, L. H., van de Koppel, J., Purkis, S. J., Rietkerk, M., Soetaert, K., van Oevelen, D. (2023) Tiger reefs: Self‐organized regular patterns in deep‐sea cold‐water coral reefs. Ecosphere, 14, (doi: 10.1002/ecs2.4654)
Lees, J. S., De La Mata, N. L., Sullivan, M. K., Wyld, M. L., Rosales, B. M., Cutting, R., Hedley, J. A., Rutherford, E., Mark, P. B., Webster, A. C. (2023) Sex differences in associations between creatinine and cystatin C-based kidney function measures with stroke and major bleeding. European Stroke Journal, 8, pp. 756-768. (doi: 10.1177/23969873231173282)
Shemilt, R., Sullivan, M. K., Hanlon, P., Jani, B., De La Mata, N., Rosales, B., Elyan, B. M.P., Wyld, M., Hedley, J.A., Cutting, R., McAllister, D. A., Webster, A.C., Mark, P. B., Lees, J. S. (2023) Sex differences in the diagnosis of advanced cancer and subsequent outcome in people with chronic kidney disease: an analysis of a national population cohort. medRxiv, (doi: 10.1101/2023.08.22.23294412)
Stevens, K. I., Lees, J. S. (2023) Measure and risk: cystatin C, creatinine and controversy in CKD. Nephrology Dialysis Transplantation, 38, pp. 1785-1788. (doi: 10.1093/ndt/gfad113)
Lees, J. S., Dobbin, S. J.H., Elyan, B. M.P., Gilmour, D. F., Tomlinson, L. P., Lang, N. N., Mark, P. B. (2023) A systematic review and meta-analysis of the effect of intravitreal VEGF inhibitors on cardiorenal outcomes. Nephrology Dialysis Transplantation, 38, pp. 1666-1681. (doi: 10.1093/ndt/gfac305)
Grant, C. H., Salim, E., Lees, J. S., Stevens, K. I. (2023) Deprivation and chronic kidney disease—a review of the evidence. Clinical Kidney Journal, 16, pp. 1081-1091. (doi: 10.1093/ckj/sfad028)
Elyan, B. M.P., Rankin, S., Jones, R., Lang, N. N., Mark, P. B., Lees, J. S. (2023) Kidney disease patient representation in trials of combination therapy with VEGF-signaling pathway inhibitors and immune checkpoint inhibitors: a systematic review. Kidney Medicine, 5, (doi: 10.1016/j.xkme.2023.100672)
Mayne, K. J., Sullivan, M. K., Lees, J. S. (2023) Sex and gender differences in the management of chronic kidney disease and hypertension. Journal of Human Hypertension, (doi: 10.1038/s41371-023-00843-9)
Stevens, K. I., Graham-Brown, M., Lees, J. S. (2023) Let's get physical: considering and overcoming the barriers to physical activity in CKD. Nephrology Dialysis Transplantation, 38, pp. 1405-1407. (doi: 10.1093/ndt/gfad002)
Lees, J. S., Elyan, B. M.P., Hermann, S. M., Lang, N. N., Jones, R. J., Mark, P. B. (2023) The ‘other’ big complication: how chronic kidney disease impacts on cancer risks and outcomes. Nephrology Dialysis Transplantation, 38, pp. 1071-1079. (doi: 10.1093/ndt/gfac011)
Mayne, K. J., Lees, J. S., Herrington, W. G. (2023) Bioimpedance in CKD: an untapped resource? Nephrology Dialysis Transplantation, 38, pp. 583-585. (doi: 10.1093/ndt/gfac275)
Mayne, K. J., Lees, J. S., Mark, P. B. (2023) Cardiovascular complications of chronic kidney disease. Medicine, 51, pp. 190-195. (doi: 10.1016/j.mpmed.2022.12.008)
Mayne, K. J., Lees, J. S., Rutherford, E., Thomson, P. C., Traynor, J. P., Dey, V., Lang, N. N., Mark, P. B. (2023) Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios: associations with mortality in a haemodialysis cohort. Clinical Kidney Journal, 16, pp. 512-520. (doi: 10.1093/ckj/sfac248)
Chen, D. C., Lees, J. S., Lu, K., Scherzer, R., Rutherford, E., Mark, P. B., Kanaya, A. M., Shlipak, M. G., Estrella, M. M. (2023) Differential associations of cystatin C versus creatinine‐based kidney function with risks of cardiovascular event and mortality among South Asian individuals in the UK Biobank. Journal of the American Heart Association, 12, (doi: 10.1161/JAHA.122.027079)
De Clippele, L. H., Alonso Díaz, L., Andradi-Brown, D. A., Erdi Lazuardi, M., Iqbal, M., Musthofa Zainudin, I., Prabuning, D., van Hooidonk, R., Hakim, A., Agung, F., Dermawan, A., Hennige, S. J. (2023) Evaluating annual severe coral bleaching risk for marine protected areas across Indonesia. Marine Policy, 148, (doi: 10.1016/j.marpol.2022.105428)
Sullivan, M. K., Jani, B. D., Rutherford, E., Welsh, P., McConnachie, A., Major, R. W., McAllister, D., Nitsch, D., Mair, F. S., Mark, P. B., Lees, J. S. (2023) Potential impact of NICE guidelines on referrals from primary care to nephrology: a primary care database and prospective research study. British Journal of General Practice, 73, pp. e141-e147. (doi: 10.3399/BJGP.2022.0145)
2022
Lithgow, H., Johnston, L., Ho, F. K., Celis-Morales, C., Cobley, J., Raastad, T., Hunter, A. M., Lees, J. S., Mark, P. B., Quinn, T. J., Gray, S. R. (2022) Protocol for a randomised controlled trial to investigate the effects of vitamin K2 on recovery from muscle-damaging resistance exercise in young and older adults—the TAKEOVER study. Trials, 23, (doi: 10.1186/s13063-022-06937-y)
Lees, J. S., Shlipak, M. G. (2022) Age-adapted eGFR thresholds underestimate the risks beyond kidney failure associated with CKD in older populations. Journal of the American Geriatrics Society, 70, pp. 3660-3664. (doi: 10.1111/jgs.18046)
Mayne, K. J., Shemilt, R., Keane, D. F., Lees, J. S., Mark, P. B., Herrington, W. G. (2022) Bioimpedance indices of fluid overload and cardiorenal outcomes in heart failure and chronic kidney disease: a systematic review. Journal of Cardiac Failure, 28, pp. 1628-1641. (doi: 10.1016/j.cardfail.2022.08.005)
Lees, J. S., Rutherford, E., Stevens, K. I., Chen, D. C., Scherzer, R., Estrella, M. M., Sullivan, M. K., Ebert, N., Mark, P. B., Shlipak, M. G. (2022) Assessment of Cystatin C level for risk stratification in adults with chronic kidney disease. JAMA Network Open, 5, (doi: 10.1001/jamanetworkopen.2022.38300)
Lithgow, H., Johnston, L., Ho, F. K., Celis- Morales, C., Cobley, J., Raastad, T., Hunter, A. M., Lees, J., Mark, P. B., Quinn, T. J., Gray, S. (2022) Protocol for a randomised controlled trial to investigate the effects of vitamin K2 on recovery from muscle damaging resistance exercise in young and older adults – The TAKEOVER study. Research Square, (doi: 10.21203/rs.3.rs-1020009/v1)
Lees, J., Rutherford, E., Stevens, K., Chen, D., Scherzer, R., Estrella, M., Sullivan, M., Ebert, N., Mark, P., Shlipak, M. (2022) FC077: Cystatin C testing improves risk stratification associated with chronic kidney disease without adopting age-adapted diagnostic thresholds : a UK Biobank Study. Nephrology Dialysis Transplantation, 37, pp. I842-I843. (doi: 10.1093/ndt/gfac114.001)
Sullivan, M. K., Lees, J. S., Drake, T. M., Docherty, A. B., Oates, G., Hardwick, H. E., Russell, C. D., Merson, L., Dunning, J., Nguyen-Van-Tam, J. S., Openshaw, P., Harrison, E. M., Baillie, J. K., ISARIC4C Investigators, , Semple, M. G., Ho, A., Mark, P. B., Scott, J. T., Davis, C. (2022) Acute kidney injury in patients hospitalised with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. Nephrology Dialysis Transplantation, 37, pp. 271-284. (doi: 10.1093/ndt/gfab303)
Lees, J. S., Mark, P. B. (2022) Insights into vitamin K metabolism in chronic kidney disease: more complicated than kale deficiency. Kidney International, 101, pp. 216-219. (doi: 10.1016/j.kint.2021.11.022)
Lees, J. S., Mark, P. B. (2022) Vitamin K supplementation and vascular health after kidney transplantation: authors' response. American Journal of Transplantation, 22, pp. 320-321. (doi: 10.1111/ajt.16769)
Lees, J. S., Hanlon, P., Butterly, E. W., Wild, S. H., Mair, F. S., Taylor, R. S., Guthrie, B., Gillies, K., Dias, S., Welton, N. J., McAllister, D. A. (2022) Effect of age, sex, and morbidity count on trial attrition: meta-analysis of individual participant level data from phase 3/4 industry funded clinical trials. BMJ Medicine, 1, (doi: 10.1136/bmjmed-2022-000217)
2021
Rankin, A. J., Mangion, K., Lees, J. S., Rutherford, E., Gillis, K. A., Edy, E., Dymock, L., Treibel, T. A., Radjenovic, A., Patel, R. K., Berry, C., Roditi, G., Mark, P. B. (2021) Myocardial changes on 3T cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal. Journal of Cardiovascular Magnetic Resonance, 23, (doi: 10.1186/s12968-021-00822-4)
De Clippele, L. H., van der Kaaden, A.-S., Maier, S. R., de Froe, E., Roberts, J. M. (2021) Biomass mapping for an improved understanding of the contribution of cold-water coral carbonate mounds to C and N cycling. Frontiers in Marine Science, 8, (doi: 10.3389/fmars.2021.721062)
Sullivan, M. K., Jani, B. D., Lees, J. S., Welsh, C. E., McConnachie, A., Stanley, B., Welsh, P., Nicholl, B. I., Lyall, D. M., Carrero, J.-J., Nitsch, D., Sattar, N., Mair, F. S., Mark, P. B. (2021) Multimorbidity and the risk of major adverse kidney events: findings from the UK Biobank cohort. Clinical Kidney Journal, 14, pp. 2409-2419. (doi: 10.1093/ckj/sfab079)
Rankin, A. J., Zhu, L., Mangion, K., Rutherford, E., Gillis, K. A., Lees, J. S., Woodward, R., Patel, R. K., Berry, C., Roditi, G., Mark, P. B. (2021) Global longitudinal strain by feature tracking cardiovascular MRI predicts mortality in patients with end stage kidney disease. Clinical Kidney Journal, 14, pp. 2187-2196. (doi: 10.1093/ckj/sfab020)
Lees, J. S., Rankin, A. J., Gillis, K. A., Zhu, L. Y., Mangion, K., Rutherford, E., Roditi, G. H., Witham, M. D., Chantler, D., Panarelli, M., Jardine, A. G., Mark, P. B. (2021) The ViKTORIES trial: a randomised, double-blind, placebo-controlled trial of vitamin K supplementation to improve vascular health in kidney transplant recipients. American Journal of Transplantation, 21, pp. 3356-3368. (doi: 10.1111/ajt.16566)
Kazanidis, G., Henry, L.-A., Vad, J., Johnson, C., De Clippele, L., Roberts, J. M. (2021) Sensitivity of a cold-water coral reef to interannual variability in regional oceanography. Diversity and Distributions, 27, pp. 1719-1731. (doi: 10.1111/ddi.13363)
Hennige, S.J., Larsson, A.I., Orejas, C., Gori, A., De Clippele, L. H., Lee, Y.C., Jimeno, G., Georgoulas, K., Kamenos, N.A., Roberts, J. M. (2021) Using the Goldilocks Principle to model coral ecosystem engineering. Proceedings of the Royal Society of London Series B: Biological Sciences, 288, (doi: 10.1098/rspb.2021.1260)
Lees, J. S., Ho, F., Parra -Soto, S., Celis-Morales, C., Welsh, P., Sullivan, M. K., Jani, B. D., Sattar, N., Lang, N. N., Pell, J. P., Webster, A. C., Mark, P. B. (2021) Kidney function and cancer risk: an analysis using creatinine and cystatin C in a cohort study. EClinicalMedicine, 38, (doi: 10.1016/j.eclinm.2021.101030)
Li, K. K. et al. (2021) Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - a high risk community-hospital interface. Journal of Infection, 83, pp. 96-103. (doi: 10.1016/j.jinf.2021.04.020)
Lees, J. S., Mark, P. B., Witham, M. D. (2021) Vitamin K and vascular calcification. Current Opinion in Nephrology and Hypertension, 30, pp. 430-436. (doi: 10.1097/MNH.0000000000000712)
Edy, E., Rankin, A. J., Lees, J. S., Hall Barrientos, P., Woodward, R., Stoumpos, S., Koktzoglou, I., Edelman, R. R., Radjenovic, A., Mark, P. B., Roditi, G. H. (2021) Cardiovascular magnetic resonance for the detection of descending thoracic aorta calcification in patients with end-stage renal disease. Journal of Cardiovascular Magnetic Resonance, 23, (doi: 10.1186/s12968-021-00769-6)
Lees, J. S., Mark, P. B. (2021) Fruit for thought: lifestyle interventions to reduce the risk of future chronic kidney disease. Nephrology Dialysis Transplantation, 36, pp. 963-965. (doi: 10.1093/ndt/gfaa266)
De Clippele, L. H., Risch, D. (2021) Measuring sound at a cold-water coral reef to assess the impact of COVID-19 on noise pollution. Frontiers in Marine Science, 8, (doi: 10.3389/fmars.2021.674702)
O’Sullivan, E. D., Lees, J. S., Howie, K. L., Pugh, D., Gillis, K. A., Traynor, J. P., Macintyre, I., Mark, P. B. (2021) Prolonged SARS-CoV-2 viral shedding in patients with chronic kidney disease. Nephrology, 26, pp. 328-332. (doi: 10.1111/nep.13844)
De Clippele, L., Michelotti, M., Findlay, C. R., Cartwright, A., Fang, Q., Wheatley, C., Sladen, A., Scott-Somme, K., Harding, H. R., Jackson, J., Hepburn, L. E., Giannotti, J., Carroll, G., Heidtke, N., Worrall, A. M., De Meyer, K. (2021) The Future of Our Seas: Marine scientists and creative professionals collaborate for science communication. Research for All, 5, pp. 134-156. (doi: 10.14324/RFA.05.1.11)
Lees, J. S., Mark, P. B. (2021) Cystatin C to predict renal disease and cardiovascular risk. Nephrology Dialysis Transplantation, 36, pp. 39-41. (doi: 10.1093/ndt/gfaa152)
2020
Witham, M. D., Lees, J. S., White, M., Band, M., Bell, S., Chantler, D. J., Ford, I., Fulton, R. L., Kennedy, G., Littleford, R. C., McCrea, I. V., McGlynn, D., Panarelli, M., Ralston, M. R., Rutherford, E., Severn, A., Thomson, N., Traynor, J. P., Struthers, A. D., Wetherall, K., Mark, P. B. (2020) Vitamin K supplementation to improve vascular stiffness in chronic kidney disease: the K4Kidneys randomised controlled trial. Journal of the American Society of Nephrology, 31, pp. 2434-2445. (doi: 10.1681/ASN.2020020225)
Lees, J. S., Mangion, K., Rutherford, E., Witham, M. D., Woodward, R., Roditi, G., Hopkins, T., Brooksbank, K., Jardine, A., Mark, P. B. (2020) Vitamin K for kidney transplant organ recipients: investigating vEssel stiffness (ViKTORIES): study rationale and protocol of a randomised controlled trial. Open Heart, 7, (doi: 10.1136/openhrt-2019-001070)
2019
Lees, J. S., Welsh, C. E., Celis-Morales, C. A., Mackay, D., Lewsey, J., Gray, S. R., Lyall, D. M., Cleland, J. G., Gill, J. M.R., Jhund, P. S., Pell, J., Sattar, N., Welsh, P., Mark, P. B. (2019) Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease. Nature Medicine, 25, pp. 1753-1760. (doi: 10.1038/s41591-019-0627-8)
Grant, C. H., Gillis, K. A., Lees, J. S., Traynor, J. P., Mark, P. B., Stevens, K. I. (2019) Proton pump inhibitor use and progression to major adverse renal events: a competing risk analysis. QJM: An International Journal of Medicine, 112, pp. 835-840. (doi: 10.1093/qjmed/hcz166)
Elyan, B. M.P., Lees, J. S., Gillis, K. A., Mackinnon, B., Fox, J. G., Geddes, C. C., McQuarrie, E. P. (2019) Obesity is not associated with progression to end stage renal disease in patients with biopsy-proven glomerular diseases. BMC Nephrology, 20, (doi: 10.1186/s12882-019-1434-7)
Lees, J.S., Chapman, F.A., Witham, M.D., Jardine, A.G., Mark, P.B. (2019) Vitamin K status, supplementation and vascular disease: a systematic review and meta-analysis. Heart, 105, pp. 938-945. (doi: 10.1136/heartjnl-2018-313955)
Gillis, K. A., Lees, J. S., Ralston, M. R., Glen, J. A., Stevenson, K. S., McManus, S. K., Geddes, C. C., Clancy, M., Traynor, J. P., Mark, P. B. (2019) Interaction between socioeconomic deprivation and likelihood of pre‐emptive transplantation: influence of competing risks and referral characteristics – a retrospective study. Transplant International, 32, pp. 153-162. (doi: 10.1111/tri.13336)
Lees, J.S., Findlay, M.D., Mark, P.B., Geddes, C.C. (2019) The impact of coronary angiography on renal transplant function. QJM: An International Journal of Medicine, 112, pp. 23-27. (doi: 10.1093/qjmed/hcy216)
2018
Lees, J. S., McQuarrie, E. P., Mackinnon, B. (2018) Renal biopsy: it is time for pragmatism and consensus. Clinical Kidney Journal, 11, pp. 605-609. (doi: 10.1093/ckj/sfy075)
Stoumpos, S., Lees, J., Welsh, P., Hund, M., Geddes, C. C., Nelson, S. M., Mark, P. B. (2018) The utility of anti-Müllerian hormone in women with chronic kidney disease, on haemodialysis and after kidney transplantation. Reproductive BioMedicine Online, 36, pp. 219-226. (doi: 10.1016/j.rbmo.2017.11.003)
2017
Lees, J. S., McQuarrie, E. P., Mordi, N., Geddes, C. C., Fox, J. G., Mackinnon, B. (2017) Risk factors for bleeding complications after nephrologist-performed native renal biopsy. Clinical Kidney Journal, 10, pp. 573-577. (doi: 10.1093/ckj/sfx012)
2015
Lees, J. S., Mark, P. B., Jardine, A. G. (2015) Cardiovascular complications of chronic kidney disease. Medicine, 43, pp. 469-473. (doi: 10.1016/j.mpmed.2015.05.009)
2013
Lees, J.S., Church, N., Langdale-Brown, B., Bellamy, C., Gibson, P., Watson, S. (2013) IgG4-related disease: a novel, important but easily missed condition. Journal of the Royal College of Physicians of Edinburgh, 43, pp. 126-133. (doi: 10.4997/JRCPE.2013.208)
Altman, D. G., Antonic, A., Sena, E. S., Lees, J. S., Wills, T. E., Skeers, P., Batchelor, P. E., Macleod, M. R., Howells, D. W. (2013) Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies. PLoS Biology, 11, (doi: 10.1371/journal.pbio.1001738)
What can machine learning do for us?
Machine Learning covers a variety of techniques which are specialty agnostic and can be applied to where there are large quantities of data available. In medicine, these principles can be used for varied purposes: our current work includes predicting osteoporosis based on routinely collected data, detecting vertebral fracture on computed tomography, mortality prediction in COVID-19 infections, and prediction of dysglycaemia in hospital inpatients.
What type of work do we do?
- Enhanced Screening – predicting disease based on routinely collected data.
- Outcome prediction – using clinical data to predict hypoglycaemia and mortality.
- Image Analysis – analysing medical imaging for diagnosis or outcome prediction.
- Synthetic Data – generation of synthetic data to run massive virtual clinical trials.
How will our research have an impact?
- Synthetic data creation and virtual trials could allow for more personalised treatment plans.
- Novel screening tools could allow for earlier identification and intervention in a variety of diseases.
- Risk stratification and mortality predictors can allow for more appropriate interventions in unwell patients.
- Clustering within diseases may identify subtypes that require tailored treatments.