Cardio-oncology
Led by Professor Ninian Lang, the Cardio-Oncology Unit in SCMH focuses on the potential adverse cardiovascular effects of cancer and its treatment.
Staff
Publications
2024
Harrison, L. L., Fu, E. L., Thomson, P. C., Traynor, J. P., Mark, P. B., Stoumpos, S. (2024) Impact of arteriovenous fistula formation on trajectory of kidney function decline: a target trial emulation. Clinical Kidney Journal,
De Biase, N., Del Punta, L., L'Hoyes, W., Pellicori, P., Cleland, J. G.F., Masini, G., Gargani, L., Moura-Ferreira, S., Hoedemakers, S., Di Fiore, V., Herbots, L., Stassen, J., Mengozzi, A., Armenia, S., Taddei, S., Masi, S., Verwerft, J., Pugliese, N. R. (2024) Associations of iron deficiency with cardiac function, congestion, exercise capacity and prognosis in heart failure. European Journal of Heart Failure,
Osmanska, J., Petrie, M. C., Docherty, K. F., Lee, M. M.Y., McMurray, J. J.V., Campbell, R. (2024) Subcutaneous furosemide in heart failure: a systematic review. European Heart Journal: Cardiovascular Pharmacotherapy, (doi: 10.1093/ehjcvp/pvae083)
Lambourg, E. J., Fu, E. L., McGurnaghan, S., Conway, B. R., Dhaun, N., Grant, C. H., Pearson, E. R., Mark, P. B., Petrie, J., Colhoun, H., Bell, S., McCrimmon, R., Armstrong, C., Emslie-Smith, A., Lindsay, R., MacRury, S., McKnight, J., Pearson, D., McKinstry, B. (2024) Stopping versus continuing metformin in patients with advanced CKD: A nationwide Scottish target trial emulation study. American Journal of Kidney Diseases, (doi: 10.1053/j.ajkd.2024.08.012)
Averbuch, T., Lee, S. F., Zagorski, B., Pandey, A., Petrie, M. C., Biering‐Sorensen, T., Xie, F., Van Spall, H. G.C. (2024) Long‐term clinical outcomes and healthcare resource utilization in male and female patients following hospitalization for heart failure. European Journal of Heart Failure, (doi: 10.1002/ejhf.3499)
Main, A., Mary, S., Sin, Y. Y., Wright, T. A., Ling, J., Blair, C. M., Smith, G. L., Fuller, W., Baillie, G. S. (2024) SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline. International Journal of Biochemistry and Cell Biology, 176, (doi: 10.1016/j.biocel.2024.106668)
Rochmawati, I. D., Deo, S., Lees, J. S., Mark, P. B., Sattar, N., Celis-Morales, C., Pell, J. P., Welsh, P., Ho, F. K. (2024) Adding traditional and emerging biomarkers for risk assessment in secondary prevention: a prospective cohort study of 20,656 patients with cardiovascular disease. European Journal of Preventive Cardiology, (doi: 10.1093/eurjpc/zwae352)
Dieden, A., Girerd, N., Ottosson, F., Molvin, J., Pareek, M., Melander, O., Bachus, E., Råstam, L., Lindblad, U., Daka, B., Leósdóttir, M., Nilsson, P. M., Olsen, M. H., Clark, A. L., Cleland, J. G.F., Delles, C., González, A., Lamiral, Z., Duarte, K., Rossignol, P., Zannad, F., Gudmundsson, P., Jujić, A., Magnusson, M. (2024) Proteomic biomarkers and pathway analysis for progression to heart failure in three epidemiological representative cohorts. European Journal of Heart Failure, (doi: 10.1002/ejhf.3502)
Foley, P.W., Kalra, P.R., Cleland, J.G.F., Petrie, M.C., Kalra, P.A., Squire, I., Campbell, P., Chapman, C., Donnelly, P., Graham, F., Hannah, A., Lang, N.N., Matthews, I., Leslie, S.J., Pellicori, P., Piper, S., Ray, R., Savage, H.O., Spencer, C., Walsh, J., Wong, Y., Ford, I. (2024) Effect of correcting iron deficiency on the risk of serious infection in heart failure insights from the IRONMAN trial. European Journal of Heart Failure, (doi: 10.1002/ejhf.3504)
Walker, H., Sullivan, M. K., Jani, B. D., Mark, P. B., Gallacher, K. I. (2024) Exploration of patients’ and health care professionals’ perspectives of kidney failure risk and the use of the kidney failure risk equation in MULTIPle lOng-term condItions aNd frailTy (MULTIPOINT) study: a qualitative interview and focus group study protocol. BMJ Open, 14, (doi: 10.1136/bmjopen-2024-085843)
Walker, H., Day, S., Grant, C. H., Jones, C., Ker, R., Sullivan, M. K., Jani, B. D., Gallacher, K., Mark, P. B. (2024) Representation of multimorbidity and frailty in the development and validation of kidney failure prognostic prediction models: a systematic review. BMC Medicine, 22, (doi: 10.1186/s12916-024-03649-9)
Alharbi, A., Nurfianti, A., Mullen, R. F., McClure, J. D., Miller, W. H. (2024) The effectiveness of simulation-based learning (SBL) on students' knowledge and skills in nursing programs: a systematic review. BMC Medical Education, 24, (doi: 10.1186/s12909-024-06080-z)
Varga, C. R., Cleland, J. G.F., Abraham, W. T., Lip, G. Y.H., Leyva, F., Hatamizadeh, P. (2024) Implantable cardioverter defibrillator and resynchronization therapy in patients with overt chronic kidney disease. Journal of the American College of Cardiology, 84, pp. 1342-1362. (doi: 10.1016/j.jacc.2024.05.081)
Ho, F., Allan, M., Shao, H., Man, K. K.C., Jani, B. D., Lyall, D., Hastie, C., Fleming, M., Mackay, D., Cleland, J. G.F., Delles, C., Dundas, R., Lewsey, J., Ip, P., Wong, I., Welsh, P., Pearce, A., Wright, C. M., Minnis, H., Katikireddi, V., Pell, J. P. (2024) Maternal and pregnancy factors contributing to the association between area deprivation and infant mortality in England: a retrospective cohort study. Lancet Regional Health - Europe, (doi: 10.1016/j.lanepe.2024.101075)
Lee, M., Petrie, M. C., Cleland, J. G.F., Donnelly, P., Francis, M., Hannah, A., Japp, A. G., Labinjoh, C., Lang, N. N., Mainsty, C., Petrie, C. J., Piper, S. E., Williams, S. G., Ford, I., Kalra, P. R., IRONMAN Trial Investigators, (2024) Administration of ferric derisomaltose for iron deficiency and heart failure during hospital admission or at the clinic – insights from the IRONMAN trial. European Journal of Heart Failure, 26, pp. 2293-2295. (doi: 10.1002/ejhf.3394)
Liu, Q., Celis-Morales, C., Lees, J. S., Sattar, N., Ho, F., Pell, J. P., Mark, P. B., Welsh, P. (2024) Change in physical activity and its association with decline in kidney function: A UK Biobank-based cohort study. Journal of Cachexia, Sarcopenia and Muscle, 15, pp. 2046-2055. (doi: 10.1002/jcsm.13551)
Cleland, J. G.F. (2024) Home-time is good, but feeling well is better: patient-journey and quality-home-time as endpoints in heart failure trials and registries. Circulation: Heart Failure, 17, (doi: 10.1161/CIRCHEARTFAILURE.124.012263)
Sliwa, K., Rakisheva, A., Viljoen, C., Pfeffer, T., Simpson, M., Jackson, A. M., Petrie, M. C., van der Meer, P., Al Farhan, H., Jovanova, S., Mbakwem, A., Sinagra, G., Van Craenenbroeck, E., Hoevelmann, J., Johnson, M. R., Mindham, R., Chioncel, O., Kahl, K. G., Rosano, G., Tschöpe, C., Mebazaa, A., Seferovic, P., Bauersachs, J. (2024) Living with peripartum cardiomyopathy: A statement from the Heart Failure Association and the Association of Cardiovascular Nursing and Allied Professions of the European Society of Cardiology. European Journal of Heart Failure, 26, pp. 2143-2154. (doi: 10.1002/ejhf.3377)
Pellicori, P., Cuthbert, J. J., Clark, A. L., Cleland, J. G.F. (2024) Managing water and salt balance in heart failure: Is there anything else to consider other than diet and diuretics? European Journal of Heart Failure, 26, pp. 2140-2142. (doi: 10.1002/ejhf.3374)
Keene, D. et al. (2024) Predictors of the efficacy of His bundle pacing in patients with a prolonged PR interval: A stratified analysis of the HOPE‐HF randomized controlled trial. European Journal of Heart Failure, 26, pp. 2261-2268. (doi: 10.1002/ejhf.3367)
Lee, M., Aimo, A., Bayés-Genís, A. (2024) Reverse cardiac remodelling: VICTORIA for inflammation and cardiac metabolism. European Journal of Heart Failure, 26, pp. 2240-2242. (doi: 10.1002/ejhf.3421)
Yu, Y.-L. et al. (2024) Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial. Heart, 110, pp. 1180-1187. (doi: 10.1136/heartjnl-2023-323796)
Lee, M. M.Y., Codina, P., Tomasoni, D., Aimo, A. (2024) What’s new in heart failure? October 2024. European Journal of Heart Failure, 26, pp. 2049-2054. (doi: 10.1002/ejhf.3492)
Cheng, L., Hammersley, D., Ragavan, A., Javed, S., Mukhopadhyay, S., Gregson, J., Han, J., Khalique, Z., Lota, A., Pantazis, A., Baksi, A. J., Carr‐White, G., de Marvao, A., Ware, J., Tayal, U., Pennell, D. J., Cleland, J. G.F., Prasad, S. K., Halliday, B. P. (2024) Long‐term follow‐up of the TRED ‐ HF trial: Implications for therapy in patients with dilated cardiomyopathy and heart failure remission. European Journal of Heart Failure, (doi: 10.1002/ejhf.3475)
Valentova, M., Vatic, M., Garfias-Veitl, T., Sandek, A., Bekfani, T., Jankowska, E. A., Cleland, J. G.F., Clark, A. L., Lainscak, M., Ahmed, A., Jauert, N., Hasenfuss, G., Anker, S. D., Doehner, W., von Haehling, S. (2024) Diabetes mellitus is associated with low exercise capacity and impaired peripheral vasodilation in patients with heart failure – a propensity score-matched stud. Diabetes Research and Clinical Practice,
Greene, S. J. et al. (2024) Cardiovascular and renal treatment in heart failure patients with hyperkalemia or high risk of hyperkalemia: rationale and design of the CARE-HK in HF registry. Journal of Cardiac Failure, (doi: 10.1016/j.cardfail.2024.08.048)
Cuthbert, J. J., Cleland, J. G. F., Pellicori, P., Clark, A. L. (2024) Natriuresis guided diuresis in patients admitted to hospital with heart failure – barking up the wrong tree? Journal of Cardiac Failure,
Marshall, W. R., Curran, G. A., Traynor, J. P., Gillis, K. A., Mark, P. B., Lees, J. S. (2024) Sodium zirconium cyclosilicate treatment and rates of emergency interventions for hyperkalaemia: a propensity-score weighted case-control study. Clinical Kidney Journal, (doi: 10.1093/ckj/sfae313)
Coats, C. J. et al. (2024) Cardiac biomarkers and effects of aficamten in obstructive hypertrophic cardiomyopathy: the SEQUOIA-HCM trial. European Heart Journal, (doi: 10.1093/eurheartj/ehae590)
van der Meer, P., van Essen, B., Viljoen, C., Böhm, M., Jackson, A., Hilfiker-Kleiner, D., Hoevelmann, J., Mebazaa, A., Farhan, H. A., Goland, S., Ouwerkerk, W., Petrie, M. C., Seferović, P. M., Tromp, J., Sliwa, K., Bauersachs, J. (2024) Bromocriptine treatment and outcomes in peripartum cardiomyopathy: the EORP PPCM registry. European Heart Journal, (doi: 10.1093/eurheartj/ehae559)
Seferović, P. M., Paulus, W. J., Rosano, G., Polovina, M., Petrie, M. C., Jhund, P. S., Tschöpe, C., Sattar, N., Piepoli, M., Papp, Z., Standl, E., Mamas, M. A., Valensi, P., Linhart, A., Lalić, N., Ceriello, A., Döhner, W., Ristić, A., Milinković, I., Seferović, J., Cosentino, F., Metra, M., Coats, A. J.S. (2024) Diabetic myocardial disorder. A clinical consensus statement of the Heart Failure Association of the ESC and the ESC Working Group on Myocardial & Pericardial Diseases. European Journal of Heart Failure, 26, pp. 1893-1903. (doi: 10.1002/ejhf.3347)
Ryan, M., Taylor, D., Dodd, M., Spertus, J. A., Kosiborod, M. N., Shaukat, A., Docherty, K. F., Clayton, T., Perera, D., Petrie, M. C., REVIVED-BCIS2 Investigators, (2024) Effect of PCI on health status in ischemic left ventricular dysfunction: insights from REVIVED-BCIS2. JACC: Heart Failure, 12, pp. 1553-1562. (doi: 10.1016/j.jchf.2024.03.010)
Ponikowski, P. et al. (2024) Hospitalization of symptomatic patients with heart failure and moderate to severe functional mitral regurgitation treated with MitraClip: insights from RESHAPE-HF2. JACC: Heart Failure, (doi: 10.1016/j.jacc.2024.08.027)
McNeilly, S. et al. (2024) Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage. EBioMedicine, 107, (doi: 10.1016/j.ebiom.2024.105315)
Graham, F. J., Guha, K., Cleland, J. G., Kalra, P. R. (2024) Treating iron deficiency in patients with heart failure: what, why, when, how, where and who. Heart, (doi: 10.1136/heartjnl-2022-322030)
Cleland, J., Pellicori, P., Graham, F. J., Lane, R., Petrie, M. C., Ahmed, F., Squire, I. B., Ludman, A., Japp, A., Al-Mohammad, A., Clark, A. L., Szwejkowski, B., Critoph, C., Chong, V., Schiff, R., Nageh, T., Glover, J., McMurray, J. J.V., Thomson, E. A., Robertson, M., Ford, I., Kalra, P. A., Kalra, P. R. (2024) The IRONMAN trial of intravenous iron for heart failure. Adjudication of hospitalizations and deaths. Journal of the American College of Cardiology,
Elyan, B. M.P., Sullivan, M. K., Hedley, J., De La Mata, N., Webster, A. C., Venugopal, B., Jones, R. J., Lang, N. N., Mark, P. B., Lees, J. S. (2024) The impact of VEGF signalling pathway inhibitors and/or immune checkpoint inhibitors on kidney function over time: a single centre retrospective analysis. BJC Reports, 2, (doi: 10.1038/s44276-024-00081-7)
Cao, T. H., Tay, W. T., Jones, D. J.L., Cleland, J. G.F., Tromp, J., Emmens, J. E., Teng, T.‐H. K., Chandramouli, C., Slingsby, O. C., Anker, S. D., Dickstein, K., Filippatos, G., Lang, C. C., Metra, M., Ponikowski, P., Samani, N. J., Van Veldhuisen, D. J., Zannad, F., Anand, I. S., Lam, C. S.P., Voors, A. A., Ng, L. L. (2024) Heart failure with improved versus persistently reduced left ventricular ejection fraction: A comparison of the BIOSTAT‐CHF (European) study with the ASIAN‐HF registry. European Journal of Heart Failure, (doi: 10.1002/ejhf.3378)
Kazmi, S., Kambhampati, C., Rigby, A. S., Cleland, J. G.F., Kazmi, K. S., Cuthbert, J., Pellicori, P., Clark, A. L. (2024) Disease progression in chronic heart failure is linear: insights from multistate modelling. European Journal of Heart Failure, (doi: 10.1002/ejhf.3400)
Coats, C. J. et al. (2024) Dosing and safety profile of aficamten in symptomatic obstructive hypertrophic cardiomyopathy: results from from SEQUOIA‐HCM. Journal of the American Heart Association, 13, (doi: 10.1161/JAHA.124.035993)
Gustafsson, F., Petrie, M. C., Komtebedde, J., Swarup, V., Winkler, S., Hasenfuß, G., Borlaug, B. A., Mohan, R. C., Flaherty, J. D., Sverdlov, A. L., Fail, P. S., Chung, E. S., Lurz, P., Lilly, S., Kaye, D. M., Cleland, J. G.F., Cikes, M., Leon, M. B., Cutlip, D. E., van Veldhuisen, D. J., Solomon, S. D., Shah, S. J. (2024) 2-year outcomes of an atrial shunt device in HFpEF/HFmrEF: results from REDUCE LAP-HF II. JACC: Heart Failure, 12, pp. 1425-1438. (doi: 10.1016/j.jchf.2024.04.011)
Lam, C. S.P., Køber, L., Kuwahara, K., Lund, L. H., Mark, P. B., Mellbin, L. G., Schou, M., Ely Pizzato, P., Gabrielsen, A., Gasparyan, S. B., Ghiretti, A., Hartleib‐Geschwindner, J., Housler, G. J., Fanti, P., Leonsson‐Zachrisson, M., McMurray, J. J.V., Solomon, S. D. (2024) Balcinrenone plus dapagliflozin in patients with heart failure and chronic kidney disease: Results from the phase 2b MIRACLE trial. European Journal of Heart Failure, 26, pp. 1727-1735. (doi: 10.1002/ejhf.3294)
Sudesh, S., Abraham, W. T., Cleland, J. G.F., Curtis, A. B., Friedman, D. J., Gold, M. R., Kutyifa, V., Linde, C., Tang, A. S., Olivas-Martinez, A., Inoue, L. Y.T., Sanders, G. D., Al-Khatib, S. M. (2024) Cardiac resynchronization therapy in ischemic versus non-ischemic cardiomyopathy: patient-level meta-analysis of seven randomized clinical trials. JACC: Heart Failure,
Rosano, G. M.C. et al. (2024) Differences in presentation, diagnosis and management of heart failure in women. A scientific statement of the Heart Failure Association of the ESC. European Journal of Heart Failure, 26, pp. 1669-1686. (doi: 10.1002/ejhf.3284)
Carberry, J., Petrie, M. C., Lee, M. M.Y., Brooksbank, K., Campbell, R. T., Good, R., Jhund, P. S., Kellman, P., Lang, N. N., Mangion, K., Mark, P. B., McConnachie, A., McMurray, J. J.V., Meyer, B., Orchard, V., Shaukat, A., Watkins, S., Welsh, P., Sattar, N., Berry, C., Docherty, K. F. (2024) Empagliflozin to prevent progressive adverse remodelling after myocardial infarction (EMPRESS-MI): rationale and design. ESC Heart Failure, 11, pp. 2001-2012. (doi: 10.1002/ehf2.14830)
Grobbee, D. E., Filippatos, G., Desai, N. R., Coats, A. J.S., Pinto, F., Rosano, G. M.C., Cleland, J., Kammerer, J., Ramirez de Arellano, A. (2024) Epidemiology and risk factors for hyperkalaemia in heart failure. ESC Heart Failure, 11, pp. 1821-1840. (doi: 10.1002/ehf2.14661)
Docherty, K. F., McMurray, J. J.V., Kalra, P., Cleland, J. G.F., Lang, N. N., Petrie, M. C., Robertson, M., Ford, I. (2024) Intravenous iron and SGLT2 inhibitors in iron-deficient patients with heart failure and reduced ejection fraction. ESC Heart Failure, 11, pp. 1875-1879. (doi: 10.1002/ehf2.14742)
Madero, M., Chertow, G. M., Mark, P. B. (2024) SGLT2 inhibitor use in chronic kidney disease: supporting cardiovascular, kidney, and metabolic health. Kidney Medicine, 6, (doi: 10.1016/j.xkme.2024.100851)
Zahir Anjum, D., Strange, J. E., Fosbøl, E., Garred, C. H., Elmegaard, M., Andersson, C., Jhund, P. S., McMurray, J. J.V., Petrie, M. C., Kober, L., Schou, M. (2024) Use of medical therapy and risk of clinical events according to frailty in heart failure patients – A real‐life cohort study. European Journal of Heart Failure, 26, pp. 1717-1726. (doi: 10.1002/ejhf.3249)
McCallum, L., Lip, S., McConnachie, A., Brooksbank, K., MacIntyre, I., Doney, A., Llano, A., Aman, A., Caparrotta, T. M., Ingram, G., Mackenzie, I. S., Dominiczak, A. F., MacDonald, T. M., Webb, D. J., Padmanabhan, S. (2024) UMOD genotype-dependent effects of Torasemide on ambulatory blood pressure: a multicentre genotype-blinded trial. Hypertension, (doi: 10.1161/HYPERTENSIONAHA.124.23122)
Shead, K. D., Huethorst, E., Burton, F., Lang, N., Myles, R. C., Smith, G. L. (2024) Human induced pluripotent stem cell derived cardiomyocytes for pre-clinical cardiotoxicity screening. JACC: CardioOncology,
Ezad, S. M., McEntegart, M., Dodd, M., Didagelos, M., Sidik, N., Li Kam Wa, M., Morgan, H. P., Pavlidis, A., Weerackody, R., Walsh, S. J., Spratt, J. C., Strange, J., Ludman, P., Chiribiri, A., Clayton, T., Petrie, M. C., O’Kane, P., Perera, D., REVIVED-BCIS2 Investigators, (2024) Impact of Anatomical and Viability-Guided Completeness of Revascularization on Clinical Outcomes in Ischemic Cardiomyopathy. Journal of the American College of Cardiology, 84, pp. 340-350. (doi: 10.1016/j.jacc.2024.04.043)
Sullivan, M. K., Lees, J. S., Rosales, B. M., Cutting, R., Wyld, M. L., Woodward, M., Webster, A. C., Mark, P. B., De La Mata, N. (2024) Sex and the relationship between cardiometabolic risk factors and estimated GFR Decline: a population-based cohort study. American Journal of Kidney Diseases, (doi: 10.1053/j.ajkd.2024.05.007)
Bahar, J., Rahman, A., Wong, G. W.Y., Sankaranarayanan, R., Ahmed, F. Z., Taylor, R., Fuat, A., Squire, I., Cleland, J., Lip, G. Y.H., Gamble, J. H.P., Masudi, S., Joseph, P. J. S., Wong, K. (2024) Outpatient treatment of decompensated heart failure: a systematic review and study level meta-analysis. ESC Heart Failure, (doi: 10.1002/ehf2.14841)
Schou, M., Petrie, M. C., Borlaug, B. A., Butler, J., Davies, M. J., Kitzman, D. W., Shah, S. J., Verma, S., Patel, S., Chinnakondepalli, K. M., Harring, S., Abildstrøm, S. Z., Liisberg, K., Kosiborod, M. N., STEP-HFpEF Trial Committees and Investigators, (2024) Semaglutide and NYHA functional class in obesity-related heart failure with preserved ejection fraction the STEP-HFpEF program. Journal of the American College of Cardiology, 84, pp. 247-257. (doi: 10.1016/j.jacc.2024.04.038)
Collister, D., Pyne, L., Bhasin, A. A., Smyth, B., Herrington, W., Jardine, M., Mark, P. B., Badve, S., Rossignol, P., Dember, L. M., Wanner, C., Ezekowitz, J., Deveraux, P.J., Parfrey, P., Gansevoort, R., Walsh, M. (2024) Heart failure events in randomized controlled trials for adults receiving maintenance dialysis: a meta-epidemiologic study. Nephrology Dialysis Transplantation, (doi: 10.1093/ndt/gfae156)
Rubiś, P. P., Dziewięcka, E., González, A., Cleland, J. G.F. (2024) High variability in assays of blood markers of collagen turnover in cardiovascular disease: Implications for research and clinical practice. European Journal of Heart Failure, (doi: 10.1002/ejhf.3375)
Zac-Varghese, S., Mark, P., Bain, S., Banerjee, D., Chowdhury, T. A., Dasgupta, I., De, P., Fogarty, D., Frankel, A., Goldet, G., Karalliedde, J., Mallik, R., Montero, R., Sharif, A., Wahba, M., Dhatariya, K., McCafferty, K., Lioudaki, E., Winocour, P. (2024) Clinical practice guideline for the management of lipids in adults with diabetic kidney disease: abbreviated summary of the Joint Association of British Clinical Diabetologists and UK Kidney Association (ABCD-UKKA) Guideline 2024. BMC Nephrology, 25, (doi: 10.1186/s12882-024-03664-1)
Aguiar-Neves, I., Diaz, S. O., Ferreira, J. P., Girerd, N., Pellicori, P., Mariottoni, B., Cosmi, F., Hazebroek, M., Verdonschot, J. A.J., Cuthbert, J., Petutschnigg, J., Heymans, S., Staessen, J. A., Pieske, B., Edelmann, F., Clark, A. L., Rossignol, P., Fontes-Carvalho, R., Cleland, J. G., Zannad, F. (2024) Health status and effects of spironolactone in people at high risk of heart failure: the Heart OMics in AGEing (HOMAGE) randomised trial. Clinical Cardiology,
Packer, M., Cleland, J. G.F., Bauersachs, J. (2024) Great debate: SGLT2 inhibitors should be first-line treatment in heart failure with reduced ejection fraction. European Heart Journal, 45, pp. 2186-2196. (doi: 10.1093/eurheartj/ehae300)
Espersen, C., Campbell, R. T., Claggett, B. L., Lewis, E. F., Docherty, K. F., Lee, M. M.Y., Lindner, M., Brainin, P., Biering-Sørensen, T., Solomon, S. D., McMurray, J. J.V., Platz, E. (2024) Predictors of heart failure readmission and all-cause mortality in patients with acute heart failure. International Journal of Cardiology, 406, (doi: 10.1016/j.ijcard.2024.132036)
Cannata, A., Mizani, M. A., Bromage, D. I., Piper, S. E., Hardman, S. M.C., Sudlow, C., de Belder, M., Deanfield, J., Gardner, R. S., Clark, A. L., Cleland, J. G.F., McDonagh, T. A. (2024) A nationwide, population-based study on specialized care for acute heart failure throughout the COVID-19 pandemic. European Journal of Heart Failure, 26, pp. 1574-1584. (doi: 10.1002/ejhf.3306)
Lakhal-Littleton, S., Cleland, J. G. F. (2024) Iron deficiency and supplementation in heart failure. Nature Reviews Cardiology, 21, pp. 463-486. (doi: 10.1038/s41569-024-00988-1)
Denicolò, S., Reinstadler, V., Keller, F., Thöni, S., Eder, S., Heerspink, H. J.L., Rosivall, L., Wiecek, A., Mark, P. B., Perco, P., Leierer, J., Kronbichler, A., Oberacher, H., Mayer, G. (2024) Non-adherence to antidiabetic and cardiovascular medication as assessed by LC-MS/MS in urine and its association with kidney and cardiovascular outcomes in type 2 diabetes mellitus. Diabetologia, 67, pp. 1283-1294. (doi: 10.1007/s00125-024-06149-w)
Denicolò, S., Reinstadler, V., Keller, F., Thöni, S., Eder, S., Heerspink, H. J. L., Rosivall, L., Wiecek, A., Mark, P. B., Perco, P., Leierer, J., Kronbichler, A., Oberacher, H., Mayer, G. (2024) Non-adherence to cardiometabolic medication as assessed by LC-MS/MS in urine and its association with kidney and cardiovascular outcomes in type 2 diabetes mellitus. Diabetologia, 67, pp. 1283-1294. (doi: 10.1007/s00125-024-06149-w)
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2023
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Heggie, R., Wu, O., Boyd, K., Lee, M. M.Y., Petrie, M. C., McEntegart, M., Berry, C. (2020) Does routine invasive management benefit patients presenting with an acute coronary syndrome and a history of bypass surgery? The use of clinical outcomes compared with cost-effectiveness outcomes.
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2019
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Howlett, J. G., Stebbins, A., Petrie, M. C., Jhund, P. S., Castelvecchio, S., Cherniavsky, A., Sueta, C. A., Roy, A., Piña, I. L., Wurm, R., Drazner, M. H., Andersson, B., Batlle, C., Senni, M., Chrzanowski, L., Merkely, B., Carson, P., Desvigne-Nickens, P. M., Lee, K. L., Velazquez, E. J., Al-Khalidi, H. R. (2019) CABG improves outcomes in patients with ischemic cardiomyopathy 10-year follow-up of the STICH trial. JACC: Heart Failure, 7, pp. 878-887. (doi: 10.1016/j.jchf.2019.04.018)
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Packer, M. et al. (2019) Evaluation of the effect of sodium–glucose co‐transporter 2 inhibition with empagliflozin on morbidity and mortality of patients with chronic heart failure and a reduced ejection fraction: rationale for and design of the EMPEROR‐Reduced trial. European Journal of Heart Failure, 21, pp. 1270-1278. (doi: 10.1002/ejhf.1536)
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2018
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Dobbin, S. J.H., Cameron, A. C., Petrie, M. C., Jones, R. J., Touyz, R. M., Lang, N. N. (2018) Toxicity of cancer therapy: what the cardiologist needs to know about angiogenesis inhibitors. Heart, 104, pp. 1995-2002. (doi: 10.1136/heartjnl-2018-313726)
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Linde, C., Cleland, J. G.F., Gold, M. R., Daubert, J. C., Tang, A. S.L., Young, J. B., Sherfesee, L., Abraham, W. T. (2018) The interaction of sex, height, and QRS duration on the effects of cardiac resynchronization therapy on morbidity and mortality: an individual-patient data meta-analysis. European Journal of Heart Failure, 20, pp. 780-791. (doi: 10.1002/ejhf.1133)
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Lee, M. M.Y. et al. (2018) Non-Invasive Versus Invasive Management in Patients With Prior Coronary Artery Bypass Surgery With a Non-ST Segment Elevation Acute Coronary Syndrome: Comparisons Between the Randomized Controlled Pilot Trial and Registry. (doi: 10.1016/S0735-1097(18)30586-2)
Malmo, V., Kelly, A., Garten, K. S., Stolen, T., Rolim, N. P. L., Wisloff, U., Smith, G., Loennechen, J. P. (2018) Aerobic interval training prevents age-dependent vulnerability to atrial fibrillation in rodents. Frontiers in Physiology, 9, (doi: 10.3389/fphys.2018.00206)
Gho, J. M.I.H., Schmidt, A. F., Pasea, L., Koudstaal, S., Pujades-Rodriguez, M., Denaxas, S., Shah, A. D., Patel, R. S., Gale, C. P., Hoes, A. W., Cleland, J. G., Hemingway, H., Asselbergs, F. W. (2018) An electronic health records cohort study on heart failure following myocardial infarction in England: incidence and predictors. BMJ Open, 8, (doi: 10.1136/bmjopen-2017-018331)
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Petrie, M. C., Connelly, D. T., Gardner, R. S. (2018) Who needs an implantable cardioverter-defibrillator? Controversies and opportunities after DANISH. European Journal of Heart Failure, 20, pp. 413-416. (doi: 10.1002/ejhf.1135)
Velazquez, E. J., Petrie, M. C. (2018) CABG or PCI for diabetic patients with left ventricular dysfunction: closing in on the truth? Journal of the American College of Cardiology, 71, pp. 828-831. (doi: 10.1016/j.jacc.2018.01.014)
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Mark, P., Dekkers, I., Blankestijn, P., Leiner, T., Roditi, G. (2018) Letter on 'European dermatology forum S1-guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 2: Scleromyxedema, scleredema and nephrogenic systemic fibrosis' Journal of the European Academy of Dermatology and Venereology, 32, pp. e84-e85. (doi: 10.1111/jdv.14774)
Cleland, J. G.F. (2018) Physicians Addicted to Prescribing Aspirin-a Disorder Of Cardiologists (PAPA-DOC) Syndrome: the headache of nonevidence-based medicine for ischemic heart disease? JACC: Heart Failure, 6, pp. 168-171. (doi: 10.1016/j.jchf.2017.11.014)
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Cotter, G., Metra, M., Davison, B. A., Jondeau, G., Cleland, J. G.F., Bourge, R. C., Milo, O., O'Connor, C. M., Parker, J. D., Torre-Amione, G., van Veldhuisen, D. J., Kobrin, I., Rainisio, M., Senger, S., Edwards, C., McMurray, J. J.V., Teerlink, J. R. (2018) Systolic blood pressure reduction during the first 24 h in acute heart failure admission: friend or foe? European Journal of Heart Failure, 20, pp. 317-322. (doi: 10.1002/ejhf.889)
Stoumpos, S., Lees, J., Welsh, P., Hund, M., Geddes, C. C., Nelson, S. M., Mark, P. B. (2018) The utility of anti-Müllerian hormone in women with chronic kidney disease, on haemodialysis and after kidney transplantation. Reproductive BioMedicine Online, 36, pp. 219-226. (doi: 10.1016/j.rbmo.2017.11.003)
Taylor, A. H.M., Rankin, A. J., McQuarrie, E. P., Freel, M., Homer, N. Z.M., Andrew, R., Jardine, A. G., Mark, P. B. (2018) Non-uniform relationship between salt status and aldosterone activity in patients with chronic kidney disease. Clinical Science, 132, pp. 285-294. (doi: 10.1042/CS20171603)
Ouwerkerk, W., Zwinderman, A. H., Ng, L. L., Demissei, B., Hillege, H. L., Zannad, F., van Veldhuisen, D. J., Samani, N. J., Ponikowski, P., Metra, M., ter Maaten, J. M., Lang, C. C., van der Harst, P., Filippatos, G., Dickstein, K., Cleland, J. G., Anker, S. D., Voors, A. A. (2018) Biomarker-guided versus guideline-based treatment of patients with heart failure: results from BIOSTAT-CHF. Journal of the American College of Cardiology, 71, pp. 386-398. (doi: 10.1016/j.jacc.2017.11.041)
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Cleland, J. G.F., Flather, M. D., Altman, D. G., Kotecha, D. (2018) Reply: an incomplete story. Journal of the American College of Cardiology, 71, pp. 105. (doi: 10.1016/j.jacc.2017.10.078)
McCarroll, C. S. et al. (2018) Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction. Circulation, 137, pp. 57-70. (doi: 10.1161/CIRCULATIONAHA.117.028911)
Cleland, J. G.F., Bunting, K. V., Flather, M. D., Altman, D. G., Holmes, J., Coats, A. J.S., Manzano, L., McMurray, J. J.V., Ruschitzka, F., van Veldhuisen, D. J., von Lueder, T. G., Böhm, M., Andersson, B., Kjekshus, J., Packer, M., Rigby, A. S., Rosano, G., Wedel, H., Hjalmarson, Å., Wikstrand, J., Kotecha, D. (2018) Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: an individual patient-level analysis of double-blind randomized trials. European Heart Journal, 39, pp. 26-35. (doi: 10.1093/eurheartj/ehx564)
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Mark, P. B. (2018) Strategies to manage cardiovascular risk in chronic kidney disease. Nephrology Dialysis Transplantation, 33, pp. 23-25. (doi: 10.1093/ndt/gfx329)
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Pellicori, P., Urbinati, A., Zhang, J., Joseph, A. C., Costanzo, P., Lukaschuk, E., Capucci, A., Cleland, J. G.F., Clark, A. L. (2018) Clinical and prognostic relationships of pulmonary artery to aorta diameter ratio in patients with heart failure: a cardiac magnetic resonance imaging study. Clinical Cardiology, 41, pp. 20-27. (doi: 10.1002/clc.22840)
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Bouabdallaoui, N. et al. (2018) Society of Thoracic Surgeons risk score and EuroSCORE-2 appropriately assess 30-day postoperative mortality in the STICH trial and a contemporary cohort of patients with left ventricular dysfunction undergoing surgical revascularization. Circulation: Heart Failure, 11, (doi: 10.1161/circheartfailure.118.005531)
2017
Berry, C., McClure, J. D., Oldroyd, K. G. (2017) Meta-analysis of death and myocardial infarction in the DEFINE-FLAIR and iFR-SWEDEHEART trials: a hypothesis generating note of caution. Circulation, 136, pp. 2389-2391. (doi: 10.1161/CIRCULATIONAHA.117.030430)
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Duncan, G., Firth, K., George, V., Hoang, M. D., Staniforth, A., Smith, G., Denning, C. (2017) Drug-mediated shortening of action potentials in LQTS2 human induced pluripotent stem cell-derived cardiomyocytes. Stem Cells and Development, 26, pp. 1695-1705. (doi: 10.1089/scd.2017.0172)
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Masters, J., Morton, G., Anton, I., Szymanski, J., Greenwood, E., Grogono, J., Flett, A. S., Cleland, J. G.F., Cowburn, P. J. (2017) Specialist intervention is associated with improved patient outcomes in patients with decompensated heart failure: evaluation of the impact of a multidisciplinary inpatient heart failure team. Open Heart, 4, (doi: 10.1136/openhrt-2016-000547)
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2016
Torabi, A., Cleland, J. G.F., Sherwi, N., Atkin, P., Panahi, H., Kilpatrick, E., Thackray, S., Hoye, A., Alamgir, F., Goode, K., Rigby, A., Clark, A. L. (2016) Influence of case definition on incidence and outcome of acute coronary syndromes. Open Heart, 3, (doi: 10.1136/openhrt-2016-000487)
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Pellicori, P., Cleland, J. G.F., Zhang, J., Kallvikbacka-Bennett, A., Urbinati, A., Shah, P., Kazmi, S., Clark, A. L. (2016) Cardiac dysfunction, congestion and loop diuretics: their relationship to prognosis in heart failure. Cardiovascular Drugs and Therapy, 30, pp. 599-609. (doi: 10.1007/s10557-016-6697-7)
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Gillis, K. A., Mccomb, C., Patel, R. K., Stevens, K. K., Schneider, M. P., Radjenovic, A., Morris, S. T.W., Roditi, G. H., Delles, C., Mark, P. B. (2016) Non-contrast renal magnetic resonance imaging to assess perfusion and corticomedullary differentiation in health and chronic kidney disease. Nephron, 133, pp. 183-192. (doi: 10.1159/000447601)
Stoumpos, S., McNeill, S. H., Gorrie, M., Mark, P. B., Brennand, J. E., Geddes, C. C., Deighan, C. J. (2016) Obstetric and long-term kidney outcomes in renal transplant recipients: a 40 year single-centre study. Clinical Transplantation, 30, pp. 673-681. (doi: 10.1111/ctr.12732)
Jackson, C. E., Haig, C., Welsh, P., Dalzell, J. R., Tsorlalis, I. K., McConnachie, A., Preiss, D., Anker, S. D., Sattar, N., Petrie, M. C., Gardner, R. S., McMurray, J. J. V. (2016) The incremental prognostic and clinical value of multiple novel biomarkers in heart failure. European Journal of Heart Failure, 18, pp. 1491-1498. (doi: 10.1002/ejhf.543)
Emdin, C. A., Conrad, N., Kiran, A., Salimi-Khorshidi, G., Woodward, M., Anderson, S. G., Mohseni, H., Dargie, H. J., Hardman, S. M.C., McDonagh, T., McMurray, J. J.V., Cleland, J. G.F., Rahimi, K. (2016) Variation in hospital performance for heart failure management in the National Heart Failure Audit for England and Wales. Heart, 103, pp. 55-62. (doi: 10.1136/heartjnl-2016-309706)
Rutherford, E., Mark, P. (2016) What does STOP-IgAN tell us about how to treat IgA nephropathy? Journal of the Royal College of Physicians of Edinburgh, 46, pp. 23-25. (doi: 10.4997/JRCPE.2016.107)
2015
Cameron, A. C., Touyz, R. M., Lang, N. N. (2015) Vascular complications of cancer chemotherapy. Canadian Journal of Cardiology, 32, pp. 852-862. (doi: 10.1016/j.cjca.2015.12.023)
Cleland, J. G.F., Mareev, Y. (2015) CRT for heart failure and ESRD: more trials or more thought needed? Journal of the American College of Cardiology, 66, pp. 2630-2632. (doi: 10.1016/j.jacc.2015.10.022)
Solbu, M. D., Thomson, P. C., Macpherson, S., Findlay, M. D., Stevens, K. K., Patel, R. K., Padmanabhan, S., Jardine, A. G., Mark, P. B. (2015) Serum phosphate and social deprivation independently predict all-cause mortality in chronic kidney disease. BMC Nephrology, 16, (doi: 10.1186/s12882-015-0187-1)
Nam, J., Briggs, A., Layland, J., Oldroyd, K. G., Curzen, N., Sood, A., Balachandran, K., Das, R., Junejo, S., Eteiba, H., Petrie, M. C., Lindsay, M., Watkins, S., Corbett, S., O'Rourke, B., O'Donnell, A., Stewart, A., Hannah, A., McConnachie, A., Henderson, R., Berry, C. (2015) Fractional flow reserve (FFR) versus angiography in guiding management to optimise outcomes in non-ST segment elevation myocardial infarction (FAMOUS-NSTEMI) developmental trial: cost-effectiveness using a mixed trial- and model-based methods. Cost Effectiveness and Resource Allocation, 2015, (doi: 10.1186/s12962-015-0045-9)
Zinman, B., Wanner, C., Lachin, J. M., Fitchett, D., Bluhmki, E., Hantel, S., Mattheus, M., Devins, T., Johansen, O. E., Woerle, H. J., Broedl, U. C., Inzucchi, S. E., EMPA-REG OUTCOME Investigators, (2015) Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. New England Journal of Medicine, 373, pp. 2117-2128. (doi: 10.1056/NEJMoa1504720)
Jolicœur, E. M., Dunning, A., Castelvecchio, S., Dabrowski, R., Waclawiw, M. A., Petrie, M. C., Stewart, R., Jhund, P. S., Desvigne-Nickens, P., Panza, J. A., Bonow, R. O., Sun, B., San, T. R., Al-Khalidi, H. R., Rouleau, J. L., Velazquez, E. J., Cleland, J. G.F. (2015) Importance of angina in patients with coronary disease, heart failure, and left ventricular systolic dysfunction. Journal of the American College of Cardiology, 66, pp. 2092-2100. (doi: 10.1016/j.jacc.2015.08.882)
Simpson, J., Castagno, D., Doughty, R. N., Poppe, K. K., Earle, N., Squire, I., Richards, M., Andersson, B., Ezekowitz, J. A., Komajda, M., Petrie, M. C., McAlister, F. A., Gamble, G. D., Whalley, G. A., McMurray, J. J.V. (2015) Is heart rate a risk marker in patients with chronic heart failure and concomitant atrial fibrillation? Results from the MAGGIC meta-analysis. European Journal of Heart Failure, 17, pp. 1182-1191. (doi: 10.1002/ejhf.346)
Pellicori, P., Joseph, A. C., Zhang, J., Lukaschuk, E., Sherwi, N., Bourantas, C. V., Loh, H., Clark, A. L., Cleland, J. G.F. (2015) The relationship of QRS morphology with cardiac structure and function in patients with heart failure. Clinical Research in Cardiology, 104, pp. 935-945. (doi: 10.1007/s00392-015-0861-0)
Inglis, S. C., Clark, R. A., Dierckx, R., Prieto-Merino, D., Cleland, J. G.F. (2015) Structured telephone support or non-invasive telemonitoring for patients with heart failure. Cochrane Database of Systematic Reviews, 2015, (doi: 10.1002/14651858.CD007228.pub3)
Deng, L., Blanco Lopez, F. J., Stevens, H., Lu, R., Caudrillier, A., McBride, M., McClure, J. D., Grant, J., Thomas, M., Frid, M., Stenmark, K., White, K., Seto, A. G., Morrell, N. W., Bradshaw, A. C., MacLean, M. R., Baker, A. H. (2015) MicroRNA-143 activation regulates smooth muscle and endothelial cell crosstalk in pulmonary arterial hypertension. Circulation Research, 117, pp. 870-883. (doi: 10.1161/CIRCRESAHA.115.306806)
Farag, M., Mabote, T., Shoaib, A., Zhang, J., Nabhan, A. F., Clark, A. L., Cleland, J. G. (2015) Hydralazine and nitrates alone or combined for the management of chronic heart failure: a systematic review. International Journal of Cardiology, 196, pp. 61-69. (doi: 10.1016/j.ijcard.2015.05.160)
Mareev, Y., Cleland, J. G.F. (2015) Should β-blockers be used in patients with heart failure and atrial fibrillation? Clinical Therapeutics, 37, pp. 2215-2224. (doi: 10.1016/j.clinthera.2015.08.017)
Shadman, R., Poole, J. E., Dardas, T. F., Mozaffarian, D., Cleland, J. G.F., Swedberg, K., Maggioni, A. P., Anand, I. S., Carson, P. E., Miller, A. B., Levy, W. C. (2015) A novel method to predict the proportional risk of sudden cardiac death in heart failure: derivation of the Seattle Proportional Risk Model. Heart Rhythm, 12, pp. 2069-2077. (doi: 10.1016/j.hrthm.2015.06.039)
Patel, R., Jeemon, P., Stevens, K., Mccallum, L., Hastie, C., Schneider, A., Jardine, A., Mark, P., Padmanabhan, S. (2015) Association between serum phosphate and calcium, long-term blood pressure, and mortality in treated hypertensive adults. Journal of Hypertension, 33, pp. 2046-2053. (doi: 10.1097/hjh.0000000000000659)
Butcher, C., Mareev, Y., Markides, V., Mason, M., Wong, T., Cleland, J.G.F. (2015) Cardiac resynchronization therapy update: evolving indications, expanding benefit? Current Cardiology Reports, 17, (doi: 10.1007/s11886-015-0641-5)
Akehurst, C., Small, H., Sharafetdinova, L., Forrest, R., Beattie, W., Brown, C. E., Robinson, S. W., McClure, J. D., Work, L. M., Carty, D. M., McBride, M. W., Freeman, D. J., Delles, C. (2015) Differential expression of microRNA-206 and its target genes in pre-eclampsia. Journal of Hypertension, 33, pp. 2068-2074. (doi: 10.1097/HJH.0000000000000656)
Frankenstein, L., Fröhlich, H., Cleland, J. G.F. (2015) Multidisciplinary approach for patients hospitalized with heart failure. Revista Española de Cardiología (English Edition), 68, pp. 885-891. (doi: 10.1016/j.rec.2015.05.008)
Cleland, J. G.F., Freemantle, N. (2015) QRS morphology as a predictor of the response to cardiac resynchronisation therapy: fact or fashion? Heart, 101, pp. 1441-1443. (doi: 10.1136/heartjnl-2015-307553)
Fisher, M., Petrie, M., Ambery, P., Donaldson, J., McMurray, J. J.V., Ye, J. (2015) Cardiovascular safety of albiglutide in the Harmony programme: a meta-analysis. Lancet Diabetes and Endocrinology, 3, pp. 697-703. (doi: 10.1016/s2213-8587(15)00233-8)
Damy, T., Hobkirk, J., Walters, M., Ciobanu, A., Rigby, A. S., Kallvikbacka-Bennett, A., Guellich, A., Dubois-Randé, J.-L., Hittinger, L., Clark, A. L., Cleland, J. G.F. (2015) Development of a human model for the study of effects of hypoxia, exercise, and sildenafil on cardiac and vascular function in chronic heart failure. Journal of Cardiovascular Pharmacology, 66, pp. 229-238. (doi: 10.1097/FJC.0000000000000262)
Dierckx, R., Cleland, J. G.F., Pellicori, P., Zhang, J., Goode, K., Putzu, P., Boyalla, V., Clark, A. L. (2015) If home telemonitoring reduces mortality in heart failure, is this just due to better guideline-based treatment? Journal of Telemedicine and Telecare, 21, pp. 331-339. (doi: 10.1177/1357633X15574947)
Findlay, M. D., Thomson, P. C., Fulton, R. L., Solbu, M. D., Jardine, A. G., Patel, R. K., Stevens, K. K., Geddes, C. C., Dawson, J., Mark, P. B. (2015) Risk factors of ischemic stroke and subsequent outcome in hemodialysis patients. Stroke, 46, pp. 2477-2481. (doi: 10.1161/STROKEAHA.115.009095)
Stut, W., Deighan, C., Cleland, J. G., Jaarsma, T. (2015) Adherence to self-care in patients with heart failure in the HeartCycle study. Patient Preference and Adherence, 9, pp. 1195-1206. (doi: 10.2147/PPA.S88482)
McComb, C., Carrick, D., McClure, J. D., Woodward, R., Radjenovic, A., Foster, J. E., Berry, C. (2015) Assessment of the relationships between myocardial contractility and infarct tissue revealed by serial magnetic resonance imaging in patients with acute myocardial infarction. International Journal of Cardiovascular Imaging, 31, pp. 1201-1209. (doi: 10.1007/s10554-015-0678-y)
Lees, J. S., Mark, P. B., Jardine, A. G. (2015) Cardiovascular complications of chronic kidney disease. Medicine, 43, pp. 469-473. (doi: 10.1016/j.mpmed.2015.05.009)
Jackson, C. E., Haig, C., Welsh, P., Dalzell, J. R., Tsorlalis, I. K., McConnachie, A., Preiss, D., McInnes, I. B., Sattar, N., Petrie, M. C., Gardner, R. S., McMurray, J. J.V. (2015) Combined free light chains are novel predictors of prognosis in heart failure. JACC: Heart Failure, 3, pp. 618-625. (doi: 10.1016/j.jchf.2015.03.014)
Abdalrahaman, N., Mccomb, C., Foster, J. E., McLean, J., Lindsay, R. S., McClure, J., McMillan, M., Drummond, R., Gordon, D., McKay, G. A., Shaikh, M. G., Perry, C. G., Ahmed, S. F. (2015) Deficits in trabecular bone microarchitecture in young women with Type 1 diabetes mellitus. Journal of Bone and Mineral Research, 30, pp. 1386-1393. (doi: 10.1002/jbmr.2465)
Mann, J. F.E., Rossing, P., Wiȩcek, A., Rosivall, L., Mark, P., Mayer, G. (2015) Diagnosis and treatment of early renal disease in patients with type 2 diabetes mellitus: what are the clinical needs? Nephrology Dialysis Transplantation, 30, pp. iv1-iv5. (doi: 10.1093/ndt/gfv120)
Blyth, M., Anthony, I., Francq, B., Brooksbank, K., Downie, P., Powell, A., Jones, B., MacLean, A., McConnachie, A., Norrie, J. (2015) Diagnostic accuracy of the Thessaly test, standardised clinical history and other clinical examination tests (Apley's, McMurray's and joint line tenderness) for meniscal tears in comparison with magnetic resonance imaging diagnosis. Health Technology Assessment, 19, pp. 1-62. (doi: 10.3310/hta19620)
Rush, C. J., Campbell, R. T., Jhund, P. S., Connolly, E. C., Preiss, D., Gardner, R. S., Petrie, M. C., McMurray, J. J.V. (2015) Falling cardiovascular mortality in heart failure with reduced ejection fraction and implications for clinical trials. JACC: Heart Failure, 3, pp. 603-614. (doi: 10.1016/j.jchf.2015.03.013)
Cleland, J. G.F., Mareev, Y., Linde, C. (2015) Reflections on EchoCRT: sound guidance on QRS duration and morphology for CRT? European Heart Journal, 36, pp. 1948-1951. (doi: 10.1093/eurheartj/ehv264)
Askevold, E. T., Gullestad, L., Nymo, S., Kjekshus, J., Yndestad, A., Latini, R., Cleland, J. G.F., McMurray, J. J.V., Aukrust, P., Ueland, T. (2015) Secreted frizzled related protein 3 in chronic heart failure: analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA) PLoS ONE, 10, (doi: 10.1371/journal.pone.0133970)
Raphael, C. E., Finegold, J. A., Barron, A. J., Whinnett, Z. I., Mayet, J., Linde, C., Cleland, J. G.F., Levy, W. C., Francis, D. P. (2015) The effect of duration of follow-up and presence of competing risk on lifespan-gain from implantable cardioverter defibrillator therapy: who benefits the most? European Heart Journal, 36, pp. 1676-1688. (doi: 10.1093/eurheartj/ehv102)
Rankin, A. J., Rankin, S. H., Rankin, A. C. (2015) Auscultating heart and breath sounds through patients’ gowns: who does this and does it matter? Postgraduate Medical Journal, 91, pp. 379-383. (doi: 10.1136/postgradmedj-2015-133321)
MacDonald, M. R., She, L., Doenst, T., Binkley, P. F., Rouleau, J. L., Tan, R.-S., Lee, K. L., Miller, A. B., Sopko, G., Szalewska, D., Waclawiw, M. A., Dabrowski, R., Castelvecchio, S., Adlbrecht, C., Michler, R. E., Oh, J. K., Velazquez, E. J., Petrie, M. C. (2015) Clinical characteristics and outcomes of patients with and without diabetes in the Surgical Treatment for Ischemic Heart Failure (STICH) trial. European Journal of Heart Failure, 17, pp. 725-734. (doi: 10.1002/ejhf.288)
Mentz, R. J., Metra, M., Cotter, G., Milo, O., McKendry, C., Chiswell, K., Davison, B. A., Cleland, J. G.F., Bloomfield, D. M., Dittrich, H. C., Fiuzat, M., Ponikowski, P., Givertz, M. M., Voors, A. A., Teerlink, J. R., O'Connor, C. M. (2015) Early vs. late worsening heart failure during acute heart failure hospitalization: insights from the PROTECT trial. European Journal of Heart Failure, 17, pp. 697-706. (doi: 10.1002/ejhf.308)
Rog-Zielinska, E.A., Craig, M.-A., Manning, J.R., Richardson, R.V., Gowans, G.J., Dunbar, D.R., Gharbi, K., Kenyon, C.J., Holmes, M.C., Hardie, D.G., Smith, G.L., Chapman, K.E. (2015) Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α. Cell Death and Differentiation, 22, pp. 1106-1116. (doi: 10.1038/cdd.2014.181)
Ferrari, R., Böhm, M., Cleland, J. G.F., Paulus, W. J.S., Pieske, B., Rapezzi, C., Tavazzi, L. (2015) Heart failure with preserved ejection fraction: uncertainties and dilemmas. European Journal of Heart Failure, 17, pp. 665-671. (doi: 10.1002/ejhf.304)
Carrick, D., Haig, C., Rauhalammi, S., Ahmed, N., Mordi, I., McEntegart, M., Petrie, M., Eteiba, H., Lindsay, M., Watkins, S., Hood, S., Davie, A., Marous, A., Sattar, N., Welsh, P., Tzemos, N., Radjenovic, A., Ford, I., Oldroyd, K., Berry, C. (2015) Pathophysiology of LV remodeling in survivors of STEMI : inflammation, remote myocardium, and prognosis. JACC: Cardiovascular Imaging, 8, pp. 779-789. (doi: 10.1016/j.jcmg.2015.03.007)
Pellicori, P., Kallvikbacka-Bennett, A., Dierckx, R., Zhang, J., Putzu, P., Cuthbert, J., Boyalla, V., Shoaib, A., Clark, A. L., Cleland, J. G.F. (2015) Prognostic significance of ultrasound-assessed jugular vein distensibility in heart failure. Heart, 101, pp. 1149-1158. (doi: 10.1136/heartjnl-2015-307558)
Zannad, F., Greenberg, B., Cleland, J. G.F., Gheorghiade, M., van Veldhuisen, D. J., Mehra, M. R., Anker, S. D., Byra, W. M., Fu, M., Mills, R. M. (2015) Rationale and design of a randomized, double-blind, event-driven, multicentre study comparing the efficacy and safety of oral rivaroxaban with placebo for reducing the risk of death, myocardial infarction or stroke in subjects with heart failure and significant coronary artery disease following an exacerbation of heart failure: the COMMANDER HF trial. European Journal of Heart Failure, 17, pp. 735-742. (doi: 10.1002/ejhf.266)
Petrie, M.C., Boyle, J.G., McKay, G.A. (2015) Use of metformin in chronic kidney disease should continue to be based on common sense in the absence of an evidence base. Diabetic Medicine, 32, pp. 981-982. (doi: 10.1111/dme.12709)
McDonald, R. A., Halliday, C. A., Miller, A. M., Diver, L. A., Dakin, R. S., Montgomery, J., McBride, M. W., Kennedy, S., McClure, J. D., Robertson, K. E., Douglas, G., Channon, K. M., Oldroyd, K., Baker, A. H. (2015) Reducing in-stent restenosis therapeutic manipulation of miRNA in vascular remodeling and inflammation. Journal of the American College of Cardiology, 65, pp. 2314-2327. (doi: 10.1016/j.jacc.2015.03.549)
McArthur, L., Chilton, L., Smith, G. L., Nicklin, S. A. (2015) Electrical consequences of cardiac myocyte: fibroblast coupling. Biochemical Society Transactions, 43, pp. 513-518. (doi: 10.1042/BST20150035)
Al Halabi, S., Qintar, M., Hussein, A., Alraies, M. C., Jones, D. G., Wong, T., MacDonald, M. R., Petrie, M. C., Cantillon, D., Tarakji, K. G., Kanj, M., Bhargava, M., Varma, N., Baranowski, B., Wilkoff, B. L., Wazni, O., Callahan, T., Saliba, W., Chung, M. K. (2015) Catheter ablation for atrial fibrillation in heart failure patients. JACC: Clinical Electrophysiology, 1, pp. 200-209. (doi: 10.1016/j.jacep.2015.02.018)
Inglis, S. C., Conway, A., Cleland, J. G.F., Clark, R. A. (2015) Is age a factor in the success or failure of remote monitoring in heart failure? Telemonitoring and structured telephone support in elderly heart failure patients. European Journal of Cardiovascular Nursing, 14, pp. 248-255. (doi: 10.1177/1474515114530611)
Kristensen, S. L., Jhund, P. S., Køber, L., McKelvie, R. S., Zile, M. R., Anand, I. S., Komajda, M., Cleland, J. G.F., Carson, P. E., McMurray, J. J.V. (2015) Relative importance of history of heart failure hospitalization and N-terminal pro–B-type natriuretic peptide level as predictors of outcomes in patients with heart failure and preserved ejection fraction. JACC: Heart Failure, 3, pp. 478-486. (doi: 10.1016/j.jchf.2015.01.014)
Dalzell, J. R., Rocchiccioli, J. P., Weir, R. A.P., Jackson, C. E., Padmanabhan, N., Gardner, R. S., Petrie, M. C., McMurray, J. J.V. (2015) The emerging potential of the apelin-APJ system in heart failure. Journal of Cardiac Failure, 21, pp. 489-498. (doi: 10.1016/j.cardfail.2015.03.007)
Costanzo, P., Cleland, J. G.F., Pellicori, P., Clark, A. L., Hepburn, D., Kilpatrick, E. S., Perrone-Filardi, P., Zhang, J., Atkin, S. L. (2015) The obesity paradox in type 2 diabetes mellitus: relationship of body mass index to prognosis: a cohort study. Annals of Internal Medicine, 162, pp. 610-618. (doi: 10.7326/M14-1551)
Rutherford, M.A., Rankin, A.J., Yates, T.M., Mark, P.B., Perry, C.G., Reed, N.S., Freel, E.M. (2015) Management of metastatic phaeochromocytoma and paraganglioma: use of Iodine-131-meta-iodobenzylguanidine (131I-MIBG) therapy in a tertiary referral centre. QJM: An International Journal of Medicine, 108, pp. 361-368. (doi: 10.1093/qjmed/hcu208)
McCarroll, C. S., Rossor, C. L., Morrison, L. R., Morrison, L. J., Loughrey, C. M. (2015) A pre-clinical animal model of Trypanosoma brucei infection demonstrating cardiac dysfunction. PLoS Neglected Tropical Diseases, 9, (doi: 10.1371/journal.pntd.0003811)
Kukulski, T., She, L., Racine, N., Gradinac, S., Panza, J. A., Velazquez, E. J., Chan, K., Petrie, M. C., Lee, K. L., Pellikka, P. A., Romanov, A., Biernat, J., Rouleau, J. L., Batlle, C., Rogowski, J., Ferrazzi, P., Zembala, M., Oh, J. K. (2015) Implication of right ventricular dysfunction on long-term outcome in patients with ischemic cardiomyopathy undergoing coronary artery bypass grafting with or without surgical ventricular reconstruction. Journal of Thoracic and Cardiovascular Surgery, 149, pp. 1312-1321. (doi: 10.1016/j.jtcvs.2014.09.117)
Filippatos, G., Khan, S. S., Ambrosy, A. P., Cleland, J. G.F., Collins, S. P., Lam, C. S.P., Angermann, C. E., Ertl, G., Dahlström, U., Hu, D., Dickstein, K., Perrone, S. V., Ghadanfar, M., Bermann, G., Noe, A., Schweizer, A., Maier, T., Gheorghiade, M. (2015) International REgistry to assess medical practice with lOngitudinal obseRvation for Treatment of Heart Failure (REPORT-HF): rationale for and design of a global registry. European Journal of Heart Failure, 17, pp. 527-533. (doi: 10.1002/ejhf.262)
Davison, B. A., Metra, M., Cotter, G., Massie, B. M., Cleland, J. G.F., Dittrich, H. C., Edwards, C., Filippatos, G., Givertz, M. M., Greenberg, B., Ponikowski, P., Voors, A. A., O’Connor, C. M., Teerlink, J. R. (2015) Worsening heart failure following admission for acute heart failure: a pooled analysis of the PROTECT and RELAX-AHF studies. JACC: Heart Failure, 3, pp. 395-403. (doi: 10.1016/j.jchf.2015.01.007)
Smith, G. L., MacQuaide, N. (2015) The direct actions of flecainide on the human cardiac ryanodine receptor: keeping open the debate on the mechanism of action of local anesthetics in CPVT. Circulation Research, 116, pp. 1284-1286. (doi: 10.1161/CIRCRESAHA.115.306298)
Cleland, J. G.F., Butcher, C. (2015) When is it appropriate to withdraw cardiac resynchronization therapy? Guesses and evidence. JACC: Heart Failure, 3, pp. 337-339. (doi: 10.1016/j.jchf.2015.01.003)
Pellicori, P., Zhang, J., Lukaschuk, E., Joseph, A. C., Bourantas, C. V., Loh, H., Bragadeesh, T., Clark, A. L., Cleland, J. G.F. (2015) Left atrial function measured by cardiac magnetic resonance imaging in patients with heart failure: clinical associations and prognostic value. European Heart Journal, 36, pp. 733-742. (doi: 10.1093/eurheartj/ehu405)
Myles, R. C., Wang, L., Bers, D. M., Ripplinger, C. M. (2015) Decreased inward rectifying K+current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart. Journal of Physiology, 593, pp. 1479-1493. (doi: 10.1113/jphysiol.2014.279638)
Jankowska, E. A., Wojtas, K., Kasztura, M., Mazur, G., Butrym, A., Kalicinska, E., Rybinska, I., Skiba, J., von Haehling, S., Doehner, W., Anker, S. D., Banasiak, W., Cleland, J. G.F., Ponikowski, P. (2015) Bone marrow iron depletion is common in patients with coronary artery disease. International Journal of Cardiology, 182, pp. 517-522. (doi: 10.1016/j.ijcard.2014.10.006)
Metra, M., Cotter, G., El-Khorazaty, J., Davison, B. A., Milo, O., Carubelli, V., Bourge, R. C., Cleland, J. G., Jondeau, G., Krum, H., O'Connor, C. M., Parker, J. D., Torre-Amione, G., van Veldhuisen, D. J., Rainisio, M., Kobrin, I., McMurray, J. J., Teerlink, J. R. (2015) Acute heart failure in the elderly: differences in clinical characteristics, outcomes, and prognostic factors in the VERITAS Study. Journal of Cardiac Failure, 21, pp. 179-88. (doi: 10.1016/j.cardfail.2014.12.012)
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Pellicori, P., Cleland, J. G.F. (2015) Is the epidemic of heart disease really over or just evolving? American Journal of Medicine, 128, pp. e17. (doi: 10.1016/j.amjmed.2014.09.018)
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Modern anticancer drugs improve cancer survival. However, this is associated with cardiovascular toxicities, the mechanisms of which often remain poorly defined and therefore cardiovascular preventative or treatment strategies are not optimal. We aim to minimise the competing risks of cardiovascular disease in patients with cancer.
Scope of research
Our pre-clinical studies provide mechanistic insights into cancer therapy-related cardiovascular toxicity. Our clinical trials and longitudinal cohort studies aim to inform better prediction, prevention and treatment of potential or established cancer therapy-related cardiovascular toxicity. We leverage large datasets to obtain epidemiologic insights.
The clinical research basis comes via a dedicated cardiovascular-oncology service. This is the only specialist service of its kind in Scotland and based at the Beatson West of Scotland Cancer Centre (BWoSCC), the busiest cancer centre in the UK in terms of clinical activity and patient numbers as well as being the second-largest cancer centre in the UK). This is the nucleus for clinical-academic collaboration and a major source for research participant recruitment.
The theme is a component of the strategic objectives of a British Heart Foundation (BHF) Centre of Excellence Award and is well supported by further specific research grants.
Membership and collaboration
The theme supports clinical and non-clinical PhD and post-doctoral fellows. Collaboration is wide within SCMH (including nephrology, hypertension, heart failure, data science) and elsewhere in the University of Glasgow (including School of Cancer Sciences and School of Infection and Inflammation, Paul O’Gorman Leukaemia Research Centre and School of Biodiversity, One Health & Veterinary Medicine). The Cardio-Nephro-Oncology (CaNOn) group brings together representatives of all of these groups and spans pre-clinical science, clinical trials and data science. We collaborate widely both within the UK and internationally.
Selected Cardio-oncology projects
- Biomarker and PET imaging characterisation of inflammatory atheroma in patients receiving immunotherapy and angiogenesis inhibitors (BioCAPRI).
- Biomarker and imaging characterisation of BRAF and MEK inhibitor-induced cardiovascular toxicity: prospective study in patients with cancer (BioCOBRA).
- Investigating the long-term cardiac sequelae of trastuzumab therapy using cardiac MRI and comprehensive clinical phenotyping.
- Markers and mediators of angiogenesis inhibitor-induced vascular and myocardial toxicity: prospective study in patients with cancer.
- Cardiac CARE: A multicentre prospective randomised open-label blinded end-point controlled trial of high-sensitivity cardiac troponin I-guided combination angiotensin receptor blockade and beta blocker therapy to prevent cardiac toxicity in breast cancer patients receiving anthracycline adjuvant therapy.
- Improving Cardiovascular Safety Assessment, Definition and Reporting in Oncology Clinical Trials: Providing cardiovascular clarity for a new era of cancer therapeutics.
- Characterising risk factors and pathways for heart failure in patients with cancer: epidemiological insights via Safe Haven dataset.
- Treatment of renal cancer and the impact on kidney function over time: Insights from national data.
- Cardio-Oncology Research in Veterinary Medicine: Anti-VEGF tyrosine kinase inhibitors and cardiac remodelling in dogs treated for cancer.
- Extended use of induced pluripotent stem cells in cardiotoxicity screening for systemic anti-cancer therapies.
Research Unit Collaborators:
- Caroline Coats (SCMH)
- Stephen Dobbin (SCMH)
- Leanne Mooney (SCMH)
- Kyle Shead
- Rob Jones (ICS)
- Jeff Evans (ICS)
- Richard Wilson (ICS)
- Mhairi Copland (ICS)
- Iain Macpherson (ICS)
- Bala Venugopal (ICS/NHS)
- Jeff White (ICS/NHS)
- John McLay (NHS)
- Chris Halsey (ICS)
- Hing Leung (ICS)
- Imran Ahmad (ICS)
- Vignir Helgason (ICS)
- Patricia Roxburgh (ICS)
- Gillian Horne (ICS)
- Conor Crichton (One Health/Vet)
- Joanna Morris (One Health/Vet)