HF Clinical Trials Team grant success
Published: 1 December 2022
The Heart Failure clinical trials team has been successful in securing funding for 3 grants and signing contracts. This continued support allows the team to continue their academic portfolio of investigator designed studies to diagnose heart failure earlier and offer more treatment options.
The Heart Failure Clinical Trials Team (Dr Ross Campbell, Prof Mark Petrie, Dr Joanna Osmanska, Dr Katriona Brooksbank) secured a further £2.7M from SQ Innovations to conduct the phase 2 trial: Use of a novel SUBCUTaneous preparation of furosemide to facilitate early supported discharge of patients with Heart Failure: a multicentre, phase II, randomised, parallel group, active comparator-controlled trial. The aim is to support self-directed diuretic treatment in patients own home rather than a lengthy stay in hospital. This follows on from the teams successful completion of the SQ Innovation sponsored phase 1 IMP and medical device trial (a first in Glasgow).
AZ have awarded the Heart Failure Clinical Trials Team (Dr Kieran Docherty, Prof Mark Petrie, Dr Daniel Taylor-Sweet, Dr Katriona Brooksbank) £3.7M to carry out the TARTAN HF trial: Targeted assessments in high-risk patients with diabetes to identify undiagnosed Heart Failure. The funding also supports Glasgow coordination of the global SYMPHONY study: Screening for earlY heart failure diagnosis and Management in Primary care or at HOme using Natriuretic peptides and echocardiograpy. The aim is to explore if using a simple biomarker test in patients who are at risk of having Heart Failure allows early detection and treatment.
The Glasgow Biomarker Centre of Excellence in Heart Failure has been funded by Roche with an award of £3.8M. PI – Prof Mark Petrie (UoG HF team – Prof John McMurray, Dr Ninian Lang, Dr Katriona Brooksbank, Prof Pardeep Jhund, Prof Naveed Sattar, Dr Kieran Docherty, Dr Matthew Lee, Dr Paul Welsh, Dr Ross Campbell; NHS collaborators –Prof Roy Gardner, Dr Caroline Coats and Dr Joanne Simpson). The Aim is to build a long-term partnership to identify the most relevant unmet HF needs that are clinically actionable.
Together these successful funding awards continue to support the academic portfolio of investigator designed studies the Heart Failure clinical trials team deliver. The resulting publications should provide the evidence for change in patient care and guidelines through supporting early diagnosis and treatment and giving patients options for treatment at home.
First published: 1 December 2022