Artery-brain circuits of atherosclerosis by Professor Tomasz Guzik
Published: 16 May 2022
Prof Tomasz Guzik Lab has provided a significant contribution to the discovery of artery-brain circuits of atherosclerosis.
Neuroimmune cardiovascular interfaces control atherosclerosis
Sarajo K. Mohanta, Li Peng, Yuanfang Li, Shu Lu, Ting Sun, Lorenzo Carnevale, Marialuisa Perrotta, Zhe Ma, Benjamin Förstera, Karen Stanic, Chuankai Zhang, Xi Zhang, Piotr Szczepaniak, Mariaelvy Bianchini, Borhan R. Saeed, Raimondo Carnevale, Desheng Hu, Ryszard Nosalski, Fabio Pallante, Michael Beer, Donato Santovito, Ali Ertürk, Thomas C. Mettenleiter, Barbara G. Klupp, Remco T. A. Megens, Sabine Steffens, Jaroslav Pelisek, Hans-Henning Eckstein, Robert Kleemann, Livia Habenicht, Ziad Mallat, Jean-Baptiste Michel, Jürgen Bernhagen, Martin Dichgans, Giuseppe D’Agostino, Tomasz J. Guzik, Peder S. Olofsson, Changjun Yin, Christian Weber, Giuseppe Lembo, Daniela Carnevale & Andreas J. R. Habenicht
Prof Tom Guzik Lab has provided a significant contribution to the discovery of artery-brain circuits of atherosclerosis.
Abstract
Atherosclerotic plaques develop in the inner intimal layer of arteries and can cause heart attacks and strokes. As plaques lack innervation, the effects of neuronal control on atherosclerosis remain unclear. However, the immune system responds to plaques by forming leukocyte infiltrates in the outer connective tissue coat of arteries (the adventitia).
Main
The nervous and vascular systems interact at multiple levels. During ontogeny, mutually acting guidance cues synchronize morphogenesis of the peripheral nervous system (PNS) and blood vessels. In adult organisms, the central nervous system (CNS) and blood vessels form various blood–brain barriers, and blood-vessel-derived molecules regulate axon growth and angiogenesis.
Delineation of adventitial axonogenesis
Neurofilament-200-positive (NF200+) axons and axon bundles were abundant in the adventitia of aged wild-type (WT) and apolipoprotein-E-deficient (Apoe−/−) mice (Figs. 1 and 2 and Extended Data Figs. 1–4).
First published: 16 May 2022