cAMP-phosphodiesterase 4D7 (PDE4D7) forms a cAMP signalosome complex with DHX9 and is implicated in prostate cancer progression.

Chloe Gulliver, Tara Busiau, Ashleigh Byrne, Jane E. Findlay, Ralf Hoffmann, George S. Baillie

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Summary

In this paper we report the existence of a novel cyclic AMP signalosome involving PDE4D7 and DHX9, which appears to play a fundamental role in prostate cancer progression. Use of a cell-permeable disruptor peptide to disrupt the interaction between PDE4D7 and DHX9 is capable of hindering cell growth, potentially representing a new therapeutic target for prostate cancer.

First published: 21 February 2024

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Dr Chloe Gulliver

Prof George Baillie