Dr Stephen Wilkie

  • Research Associate (Paul O'Gorman Leukaemia Research Centre)

email: Stephen.Wilkie@glasgow.ac.uk
pronouns: He/him/his

Wolfson Wohl Building, Garscube Campus, Glasgow, East Dunbartonshire Council, Scotland, United Kingdom, G61 1BD

Import to contacts

Biography

I am currently investigating the role of serine metabolism in leukaemic stem cells both in vivo and in vitro through genetic, pharmaceutical and dietary interventions. Through the use of metabolomic analysis, high-resolution respirometry and analysis of large single cell RNAseq datasets I aim to uncover the metabolic vulnerabilities that may be valid therapeutic strategies to target one carbon metabolism.

My postdoctoral training in the Larsson lab focussed on the role of mitochondrial biology and metabolism in lung adenocarcinoma in vivo. To investigate this, I generated new mouse models to examine the impact of modulating mitochondrial biology on tumour growth and cell culture models to elucidate cell-autonomous mechanisms in tumour aggressivity. My research has contributed to a greater understanding of the impact of mitochondria dynamics in lung cancers

Research interests

Research groups

Publications

List by: Type | Date

Jump to: 2024 | 2023 | 2021 | 2020
Number of items: 6.

2024

Borland, G., Wilkie, S. E., Thomson, J., Wang, Z., Tullett, J. M.A., Alic, N. and Selman, C. (2024) Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan. Aging Cell, 23(5), e14141. (doi: 10.1111/acel.14141) (PMID:38465473) (PMCID:PMC11113255)

2023

Wilkie, S. E., Marcu, D. E., Carter, R. N., Morton, N. M., Gonzalo, S. and Selman, C. (2023) Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndrome. Aging, 15(12), pp. 5266-5278. (doi: 10.18632/aging.204835) (PMID:37354210) (PMCID:PMC10333079)

2021

Carter, R. N. et al. (2021) The hepatic compensatory response to elevated systemic sulfide promotes diabetes. Cell Reports, 37(6), 109958. (doi: 10.1016/j.celrep.2021.109958) (PMID:34758301) (PMCID:PMC8595646)

Wilkie, S. E., Borland, G., Carter, R. N., Morton, N. M. and Selman, C. (2021) Hydrogen sulfide in ageing, longevity and disease. Biochemical Journal, 478(19), pp. 3485-3504. (doi: 10.1042/BCJ20210517) (PMID:34613340) (PMCID:PMC8589328)

Mulvey, L., Wilkie, S. E., Borland, G., Griffiths, K., Sinclair, A., McGuinness, D., Watson, D. G. and Selman, C. (2021) Strain-specific metabolic responses to long-term caloric restriction in female ILSXISS recombinant inbred mice. Molecular and Cellular Endocrinology, 535, 111376. (doi: 10.1016/j.mce.2021.111376) (PMID:34246728) (PMCID:PMC8417819)

2020

Wilkie, S. E., Mulvey, L., Sands, W., Marcu, D. E., Carter, R. N., Morton, N. M., Hine, C., Mitchell, J. R. and Selman, C. (2020) Strain-specificity in the hydrogen sulphide signalling network following dietary restriction in recombinant inbred mice. GeroScience, 42, pp. 801-812. (doi: 10.1007/s11357-020-00168-2) (PMID:32162209) (PMCID:PMC7205779)

This list was generated on Sun Dec 22 00:32:39 2024 GMT.
Jump to: Articles
Number of items: 6.

Articles

Borland, G., Wilkie, S. E., Thomson, J., Wang, Z., Tullett, J. M.A., Alic, N. and Selman, C. (2024) Polr3b heterozygosity in mice induces both beneficial and deleterious effects on health during ageing with no effect on lifespan. Aging Cell, 23(5), e14141. (doi: 10.1111/acel.14141) (PMID:38465473) (PMCID:PMC11113255)

Wilkie, S. E., Marcu, D. E., Carter, R. N., Morton, N. M., Gonzalo, S. and Selman, C. (2023) Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndrome. Aging, 15(12), pp. 5266-5278. (doi: 10.18632/aging.204835) (PMID:37354210) (PMCID:PMC10333079)

Carter, R. N. et al. (2021) The hepatic compensatory response to elevated systemic sulfide promotes diabetes. Cell Reports, 37(6), 109958. (doi: 10.1016/j.celrep.2021.109958) (PMID:34758301) (PMCID:PMC8595646)

Wilkie, S. E., Borland, G., Carter, R. N., Morton, N. M. and Selman, C. (2021) Hydrogen sulfide in ageing, longevity and disease. Biochemical Journal, 478(19), pp. 3485-3504. (doi: 10.1042/BCJ20210517) (PMID:34613340) (PMCID:PMC8589328)

Mulvey, L., Wilkie, S. E., Borland, G., Griffiths, K., Sinclair, A., McGuinness, D., Watson, D. G. and Selman, C. (2021) Strain-specific metabolic responses to long-term caloric restriction in female ILSXISS recombinant inbred mice. Molecular and Cellular Endocrinology, 535, 111376. (doi: 10.1016/j.mce.2021.111376) (PMID:34246728) (PMCID:PMC8417819)

Wilkie, S. E., Mulvey, L., Sands, W., Marcu, D. E., Carter, R. N., Morton, N. M., Hine, C., Mitchell, J. R. and Selman, C. (2020) Strain-specificity in the hydrogen sulphide signalling network following dietary restriction in recombinant inbred mice. GeroScience, 42, pp. 801-812. (doi: 10.1007/s11357-020-00168-2) (PMID:32162209) (PMCID:PMC7205779)

This list was generated on Sun Dec 22 00:32:39 2024 GMT.

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