Dr Stephan Dreyer
- Honorary Clinical Lecturer (School of Cancer Sciences)
Research interests
Research groups
- Cancer Evolution in Time & Space
- Immunology & Cancer
- Health Inequalities to Cancer Outcomes
Publications
2024
Boey, A., Bryce, A. , Dickson, E., Coats, M., McKay, C., Jamieson, N. , Chang, D. , Holroyd, D. and Dreyer, S. (2024) The Impact of Pre-operative Indeterminate Lung Nodules in the Surgical Management of Pancreatic Ductal Adenocarcinoma. 16th World Congress of the International Hepato-Pancreato-Biliary Association, Cape Town, South Africa, 15-18 May 2024. S148. (doi: 10.1016/j.hpb.2024.03.269)
Bryce, A. , Dreyer, S., Dolan, R. , Froeling, F. and Chang, D. (2024) Host phenotypic adversity independently predicts progression to resection in neoadjuvantly-treated pancreatic cancer. 42nd Congress of the European Society of Surgical Oncology, Florence, Italy, 25-27 Oct 2023. (doi: 10.1016/j.ejso.2023.107753)
Dreyer, S., Bryce, A. , Australian Pancreatic Cancer Genome Initiative, , Biankin, A. , Jamieson, N. and Chang, D. (2024) The clinical and molecular landscape of early onset pancreatic cancer. 42nd Congress of the European Society of Surgical Oncology, Florence, Italy, 25-27 Oct 2023. (doi: 10.1016/j.ejso.2023.107348)
2023
Dreyer, S. B. et al. (2023) The impact of molecular subtyping on pathological staging of pancreatic cancer. Annals of Surgery, 277(2), e396-e405. (doi: 10.1097/SLA.0000000000005050) (PMID:36745763) (PMCID:PMC9831035)
2022
Bryce, A. S. , Dreyer, S. B., Froeling, F. E.M. and Chang, D. K. (2022) Exploring the biology of cancer-associated fibroblasts in pancreatic cancer. Cancers, 14(21), 5302. (doi: 10.3390/cancers14215302) (PMID:36358721) (PMCID:PMC9659154)
Khan, K. S. , Gall, L. S., Dreyer, S., McCollum, C., Chuntamongkol, R., Craig, C., MacKay, C., Macdonald, A. and Forshaw, M. (2022) Stage migration in newly diagnosed oesophagogastric cancer during the first wave of the COVID-19 pandemic. British Journal of Surgery, 109(8), pp. 773-774. (doi: 10.1093/bjs/znac112) (PMID:35616120)
Dreyer, S. B., Upstill-Goddard, R., Legrini, A. , Biankin, A. V. , Jamieson, N. B. and Chang, D. K. (2022) Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence. Gastroenterology, 162(1), 320-324.e4. (doi: 10.1053/j.gastro.2021.09.022) (PMID:34534536) (PMCID:PMC8721486)
Dreyer, S., Upstill-Goddard, R., Legrini, A. , Biankin, A. , Jamieson, N. and Chang, D. (2022) Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence. 15th World Congress of the International Hepato-Pancreato-Biliary Association, New York, USA, 30 Mar - 02 Apr 2022. S44-S45. (doi: 10.1016/j.hpb.2022.05.086)
2021
Casolino, R. et al. (2021) Reshaping preoperative treatment of pancreatic cancer in the era of precision medicine. Annals of Oncology, 32(2), pp. 183-196. (doi: 10.1016/j.annonc.2020.11.013) (PMID:33248227) (PMCID:PMC7840891)
Dreyer, S. B. et al. (2021) Targeting DNA damage response and replication stress in pancreatic cancer. Gastroenterology, 160(1), pp. 362-377. (doi: 10.1053/j.gastro.2020.09.043) (PMID:33039466) (PMCID:PMC8167930)
2020
Moekotte, A. L. et al. (2020) Histopathologic predictors of survival and recurrence in resected ampullary adenocarcinoma. Annals of Surgery, 272(6), pp. 1086-1093. (doi: 10.1097/SLA.0000000000003177) (PMID:30628913)
Moekotte, A. L. et al. (2020) Development and external validation of a prediction model for survival in patients with resected ampullary adenocarcinoma. European Journal of Surgical Oncology, 46(9), pp. 1717-1726. (doi: 10.1016/j.ejso.2020.04.011) (PMID:32624291)
Dreyer, S. B. et al. (2020) Precision oncology in surgery: patient selection for operable pancreatic cancer. Annals of Surgery, 272(2), pp. 366-376. (doi: 10.1097/SLA.0000000000003143) (PMID:32675551) (PMCID:PMC7373491)
Moekotte, A.L. et al. (2020) Gemcitabine-based adjuvant chemotherapy in subtypes of ampullary adenocarcinoma: international propensity score-matched cohort study. British Journal of Surgery, 107(9), pp. 1171-1182. (doi: 10.1002/bjs.11555) (PMID:32259295)
Brunton, H. et al. (2020) HNF4A and GATA6 loss reveals therapeutically actionable subtypes in pancreatic cancer. Cell Reports, 31(6), 107625. (doi: 10.1016/j.celrep.2020.107625) (PMID:32402285)
Dreyer, S.B., Jamieson, N.B. , Cooke, S.L. , Valle, J.W., McKay, C.J., Biankin, A.V. and Chang, D.K. (2020) PRECISION-Panc: the next generation therapeutic development platform for pancreatic cancer. Clinical Oncology, 32(1), pp. 1-4. (doi: 10.1016/j.clon.2019.07.011) (PMID:31378449)
Dreyer, S.B., Jamieson, N.B. , Morton, J.P. , Sansom, O.J. , Biankin, A.V. and Chang, D.K. (2020) Pancreatic cancer: from genome discovery to PRECISION-Panc. Clinical Oncology, 32(1), pp. 5-8. (doi: 10.1016/j.clon.2019.08.007) (PMID:31522943)
2019
Halbrook, C. J. et al. (2019) Macrophage-released pyrimidines inhibit gemcitabine therapy in pancreatic cancer. Cell Metabolism, 29(6), 1390-1399.e6. (doi: 10.1016/j.cmet.2019.02.001) (PMID:30827862) (PMCID:PMC6602533)
Dreyer, S. B. et al. (2019) Feasibility and clinical utility of endoscopic ultrasound guided biopsy of pancreatic cancer for next-generation molecular profiling. Chinese Clinical Oncology, 8(2), 16. (doi: 10.21037/cco.2019.04.06) (PMID:31070037)
2018
Dreyer, S.B., Jamieson, N.B. , Upstill-Goddard, R., Bailey, P.J. , McKay, C.J., Australian Pancreatic Cancer Genome Initiative, , Biankin, A.V. and Chang, D.K. (2018) Defining the molecular pathology of pancreatic body and tail adenocarcinom. British Journal of Surgery, 105(2), e183-e191. (doi: 10.1002/bjs.10772) (PMID:29341146) (PMCID:PMC5817249)
2017
Dreyer, S. B., Powell, A. G.M.T., McSorley, S. T. , Waterston, A., Going, J. J., Edwards, J. , McMillan, D. C. and Horgan, P. G. (2017) The pretreatment systemic inflammatory response is an important determinant of poor pathologic response for patients undergoing neoadjuvant therapy for rectal cancer. Annals of Surgical Oncology, 24(5), pp. 1295-1303. (doi: 10.1245/s10434-016-5684-3) (PMID:27873100)
Dreyer, S. B., Chang, D. K. , Bailey, P. and Biankin, A. V. (2017) Pancreatic cancer genomes: implications for clinical management and therapeutic development. Clinical Cancer Research, 23(7), pp. 1638-1646. (doi: 10.1158/1078-0432.CCR-16-2411) (PMID:28373362)
Articles
Dreyer, S. B. et al. (2023) The impact of molecular subtyping on pathological staging of pancreatic cancer. Annals of Surgery, 277(2), e396-e405. (doi: 10.1097/SLA.0000000000005050) (PMID:36745763) (PMCID:PMC9831035)
Bryce, A. S. , Dreyer, S. B., Froeling, F. E.M. and Chang, D. K. (2022) Exploring the biology of cancer-associated fibroblasts in pancreatic cancer. Cancers, 14(21), 5302. (doi: 10.3390/cancers14215302) (PMID:36358721) (PMCID:PMC9659154)
Khan, K. S. , Gall, L. S., Dreyer, S., McCollum, C., Chuntamongkol, R., Craig, C., MacKay, C., Macdonald, A. and Forshaw, M. (2022) Stage migration in newly diagnosed oesophagogastric cancer during the first wave of the COVID-19 pandemic. British Journal of Surgery, 109(8), pp. 773-774. (doi: 10.1093/bjs/znac112) (PMID:35616120)
Dreyer, S. B., Upstill-Goddard, R., Legrini, A. , Biankin, A. V. , Jamieson, N. B. and Chang, D. K. (2022) Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence. Gastroenterology, 162(1), 320-324.e4. (doi: 10.1053/j.gastro.2021.09.022) (PMID:34534536) (PMCID:PMC8721486)
Casolino, R. et al. (2021) Reshaping preoperative treatment of pancreatic cancer in the era of precision medicine. Annals of Oncology, 32(2), pp. 183-196. (doi: 10.1016/j.annonc.2020.11.013) (PMID:33248227) (PMCID:PMC7840891)
Dreyer, S. B. et al. (2021) Targeting DNA damage response and replication stress in pancreatic cancer. Gastroenterology, 160(1), pp. 362-377. (doi: 10.1053/j.gastro.2020.09.043) (PMID:33039466) (PMCID:PMC8167930)
Moekotte, A. L. et al. (2020) Histopathologic predictors of survival and recurrence in resected ampullary adenocarcinoma. Annals of Surgery, 272(6), pp. 1086-1093. (doi: 10.1097/SLA.0000000000003177) (PMID:30628913)
Moekotte, A. L. et al. (2020) Development and external validation of a prediction model for survival in patients with resected ampullary adenocarcinoma. European Journal of Surgical Oncology, 46(9), pp. 1717-1726. (doi: 10.1016/j.ejso.2020.04.011) (PMID:32624291)
Dreyer, S. B. et al. (2020) Precision oncology in surgery: patient selection for operable pancreatic cancer. Annals of Surgery, 272(2), pp. 366-376. (doi: 10.1097/SLA.0000000000003143) (PMID:32675551) (PMCID:PMC7373491)
Moekotte, A.L. et al. (2020) Gemcitabine-based adjuvant chemotherapy in subtypes of ampullary adenocarcinoma: international propensity score-matched cohort study. British Journal of Surgery, 107(9), pp. 1171-1182. (doi: 10.1002/bjs.11555) (PMID:32259295)
Brunton, H. et al. (2020) HNF4A and GATA6 loss reveals therapeutically actionable subtypes in pancreatic cancer. Cell Reports, 31(6), 107625. (doi: 10.1016/j.celrep.2020.107625) (PMID:32402285)
Dreyer, S.B., Jamieson, N.B. , Cooke, S.L. , Valle, J.W., McKay, C.J., Biankin, A.V. and Chang, D.K. (2020) PRECISION-Panc: the next generation therapeutic development platform for pancreatic cancer. Clinical Oncology, 32(1), pp. 1-4. (doi: 10.1016/j.clon.2019.07.011) (PMID:31378449)
Dreyer, S.B., Jamieson, N.B. , Morton, J.P. , Sansom, O.J. , Biankin, A.V. and Chang, D.K. (2020) Pancreatic cancer: from genome discovery to PRECISION-Panc. Clinical Oncology, 32(1), pp. 5-8. (doi: 10.1016/j.clon.2019.08.007) (PMID:31522943)
Halbrook, C. J. et al. (2019) Macrophage-released pyrimidines inhibit gemcitabine therapy in pancreatic cancer. Cell Metabolism, 29(6), 1390-1399.e6. (doi: 10.1016/j.cmet.2019.02.001) (PMID:30827862) (PMCID:PMC6602533)
Dreyer, S. B. et al. (2019) Feasibility and clinical utility of endoscopic ultrasound guided biopsy of pancreatic cancer for next-generation molecular profiling. Chinese Clinical Oncology, 8(2), 16. (doi: 10.21037/cco.2019.04.06) (PMID:31070037)
Dreyer, S.B., Jamieson, N.B. , Upstill-Goddard, R., Bailey, P.J. , McKay, C.J., Australian Pancreatic Cancer Genome Initiative, , Biankin, A.V. and Chang, D.K. (2018) Defining the molecular pathology of pancreatic body and tail adenocarcinom. British Journal of Surgery, 105(2), e183-e191. (doi: 10.1002/bjs.10772) (PMID:29341146) (PMCID:PMC5817249)
Dreyer, S. B., Powell, A. G.M.T., McSorley, S. T. , Waterston, A., Going, J. J., Edwards, J. , McMillan, D. C. and Horgan, P. G. (2017) The pretreatment systemic inflammatory response is an important determinant of poor pathologic response for patients undergoing neoadjuvant therapy for rectal cancer. Annals of Surgical Oncology, 24(5), pp. 1295-1303. (doi: 10.1245/s10434-016-5684-3) (PMID:27873100)
Dreyer, S. B., Chang, D. K. , Bailey, P. and Biankin, A. V. (2017) Pancreatic cancer genomes: implications for clinical management and therapeutic development. Clinical Cancer Research, 23(7), pp. 1638-1646. (doi: 10.1158/1078-0432.CCR-16-2411) (PMID:28373362)
Conference or Workshop Item
Boey, A., Bryce, A. , Dickson, E., Coats, M., McKay, C., Jamieson, N. , Chang, D. , Holroyd, D. and Dreyer, S. (2024) The Impact of Pre-operative Indeterminate Lung Nodules in the Surgical Management of Pancreatic Ductal Adenocarcinoma. 16th World Congress of the International Hepato-Pancreato-Biliary Association, Cape Town, South Africa, 15-18 May 2024. S148. (doi: 10.1016/j.hpb.2024.03.269)
Bryce, A. , Dreyer, S., Dolan, R. , Froeling, F. and Chang, D. (2024) Host phenotypic adversity independently predicts progression to resection in neoadjuvantly-treated pancreatic cancer. 42nd Congress of the European Society of Surgical Oncology, Florence, Italy, 25-27 Oct 2023. (doi: 10.1016/j.ejso.2023.107753)
Dreyer, S., Bryce, A. , Australian Pancreatic Cancer Genome Initiative, , Biankin, A. , Jamieson, N. and Chang, D. (2024) The clinical and molecular landscape of early onset pancreatic cancer. 42nd Congress of the European Society of Surgical Oncology, Florence, Italy, 25-27 Oct 2023. (doi: 10.1016/j.ejso.2023.107348)
Dreyer, S., Upstill-Goddard, R., Legrini, A. , Biankin, A. , Jamieson, N. and Chang, D. (2022) Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence. 15th World Congress of the International Hepato-Pancreato-Biliary Association, New York, USA, 30 Mar - 02 Apr 2022. S44-S45. (doi: 10.1016/j.hpb.2022.05.086)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- The role of cancer associated fibroblast heterogeneity in determining metastatic patterns in pancreatic and oesophageal adenocarcinoma
Office of the Chief Scientific Adviser
2022 - 2024
- The role of tumour microenvironment heterogeneity in determining metastatic patterns in pancreatic and oesophagogastric adenocarcinoma
Rosetrees Trust
2022 - 2024
- The role of tumour microenvironment heterogeneity in determining metastatic patterns in pancreatic and oesophagogastric adenocarcinoma
The Stoneygate Trust
2022 - 2024
- The role of tumour microenvironment heterogeneity in determining metastatic patterns in oesophago-gastric adenocarcinoma
Tenovus Scotland
2021 - 2023
- Characterising the immune landscape of molecular subtypes of pancreatic ductal adenocarcinoma
Cancer Research UK
2020 - 2022