2025

Hillson, L. V.S. et al. (2025) Differential immunological effects of short-course and long-course radiotherapy in locally advanced rectal cancer. Clinical Cancer Research, (Accepted for Publication)

Cammareri, P. et al. (2025) Loss of colonic fidelity enables multilineage plasticity and metastasis. Nature, 644, pp. 547-556. (doi: 10.1038/s41586-025-09125-5) (PMID:40468074) (PMCID:PMC12350155)

Bullock, E. et al. (2025) Cancer-associated fibroblast driven paracrine IL-6/STAT3 signaling promotes migration and dissemination in invasive lobular carcinoma. Breast Cancer Research, 27(1), 121. (doi: 10.1186/s13058-025-02074-x) (PMID:40597443) (PMCID:PMC12219320)

Woraharn, W. et al. (2025) Investigation of three alternative histopathological scoring methods at the invasive tumour front in colorectal cancer. Journal of Pathology: Clinical Research, 11(3), e70031. (doi: 10.1002/2056-4538.70031)

Woolley, C. E. et al. (2025) Coevolution of atypical BRAF and KRAS mutations in colorectal tumorigenesis. Molecular Cancer Research, 23(4), pp. 300-312. (doi: 10.1158/1541-7786.mcr-24-0464) (PMID:39751654) (PMCID:PMC7617415)

Dolan, R. D. et al. (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3(1), 7. (doi: 10.1038/s44276-024-00119-w) (PMID:39910331) (PMCID:PMC11799379)

2024

Pennel, K. et al. (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14(12), 1629. (doi: 10.3390/biom14121629)

Galbraith, N. J. et al. (2024) TAK1 expression is associated with increased PD-L1 and decreased cancer-specific survival in microsatellite-stable colorectal cancer. Translational Oncology, 48, 102064. (doi: 10.1016/j.tranon.2024.102064) (PMID:39068768)

Knight, Katrina, Bigley, Christopher, Pennel, Kathryn, Hay, Jennifer, Maka, Noori, McMillan, Donald ORCID: https://orcid.org/0000-0003-4260-5334, Park, James ORCID: https://orcid.org/0000-0002-6551-2037, Roxburgh, Campbell ORCID: https://orcid.org/0000-0002-2649-6695 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2024) The Glasgow Microenvironment Score: an exemplar of contemporary biomarker evolution in colorectal cancer. Journal of Pathology: Clinical Research, 10, e12385. (doi: 10.1002/2056-4538.12385) (PMID:38853386)

McKenzie, Molly, Lian, Guang-Yu, Pennel, Kathryn A.F., Quinn, Jean A. ORCID: https://orcid.org/0000-0002-8267-0993, Jamieson, Nigel B. ORCID: https://orcid.org/0000-0002-9552-4725 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2024) NFκB signalling in colorectal cancer: examining the central dogma of IKKα and IKKβ signalling. Heliyon, 10(12), e32904. (doi: 10.1016/j.heliyon.2024.e32904) (PMID:38975078) (PMCID:PMC11226910)

Hatthakarnkul, P. et al. (2024) Histopathological tumour microenvironment score independently predicts outcome in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 10(3), e12374. (doi: 10.1002/2056-4538.12374) (PMID:38650367) (PMCID:PMC11035902)

Pennel, Kathryn, Dutton, Louise ORCID: https://orcid.org/0000-0002-9336-7826, Melissourgou-Syka, Lydia ORCID: https://orcid.org/0000-0002-0926-2328, Roxburgh, Campbell ORCID: https://orcid.org/0000-0002-2649-6695, Birch, Joanna ORCID: https://orcid.org/0000-0001-9522-8435 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2024) Novel radiation and targeted therapy combinations for improving rectal cancer outcomes. Expert Reviews in Molecular Medicine, 26, e14. (doi: 10.1017/erm.2024.15) (PMID:38623751) (PMCID:PMC11140547)

Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, 64. (doi: 10.1186/s13046-024-02958-4) (PMID:38424636) (PMCID:PMC10905886)

2023

Beach, C. et al. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133(23), e168277. (doi: 10.1172/JCI168277) (PMID:37824211) (PMCID:PMC10688992)

Greenland, Kyle K., Pennel, Kathryn, Cioccoloni, Giorgia, Rogerson, Connor, Barnieh, Francis M. and Speirs, Valerie (2023) Trailblazers in cancer research: the next generation – the British Association of Cancer Research early-career conference. Biology Open, 12(10), bio060121. (doi: 10.1242/bio.060121) (PMID:37846765) (PMCID:PMC10602000)

Vande Voorde, J. et al. (2023) Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature Metabolism, 5(8), pp. 1303-1318. (doi: 10.1038/s42255-023-00857-0) (PMID:37580540) (PMCID:PMC10447251)

Hatthakarnkul, P. et al. (2023) Protein expression of S100A2 reveals it association with patient prognosis and immune infiltration profile in colorectal cancer. Journal of Cancer, 14(10), pp. 1837-1847. (doi: 10.7150/jca.83910) (PMID:37476187) (PMCID:PMC10355195)

Pennel, Kathryn, Morrow, Elizabeth, Hatthakarnkul, Phimmada, Leslie, Holly ORCID: https://orcid.org/0000-0001-8898-3600, Mallon, Elizabeth, Andersen, Ditte, Jamieson, Nigel ORCID: https://orcid.org/0000-0002-9552-4725, McMillan, Donald ORCID: https://orcid.org/0000-0003-4260-5334, Roseweir, Antonia ORCID: https://orcid.org/0000-0001-6158-1564 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2023) High expression of STAT3 within the tumour-associated stroma predicts poor outcome in breast cancer patients. Cancer Medicine, 12(12), pp. 13225-13240. (doi: 10.1002/cam4.6014) (PMID:37199043) (PMCID:PMC10315752)

Wood, C. S. et al. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83(8), pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794) (PMID:37057593) (PMCID:PMC10102851)

Alexander, P.G., van Wyk, H.C. ORCID: https://orcid.org/0000-0002-4978-5000, Pennel, K.A.F., Hay, J., McMillan, D.C. ORCID: https://orcid.org/0000-0003-4260-5334, Horgan, P.G. ORCID: https://orcid.org/0000-0001-5557-7905, Roxburgh, C.S.D. ORCID: https://orcid.org/0000-0002-2649-6695, Edwards, J. ORCID: https://orcid.org/0000-0002-7192-6906 and Park, J.H. ORCID: https://orcid.org/0000-0002-6551-2037 (2023) The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer. British Journal of Cancer, 128(4), pp. 556-567. (doi: 10.1038/s41416-022-02069-x) (PMID:36476660) (PMCID:PMC9938140)

2022

Pennel, K. A. F. et al. (2022) CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer. Journal of Pathology: Clinical Research, 8(6), pp. 509-520. (doi: 10.1002/cjp2.290) (PMID:35879507) (PMCID:PMC9535100)

Alexander, P. G. et al. (2022) The relationship between the Glasgow Microenvironment Score and markers of epithelial-mesenchymal transition in TNM II-III colorectal cancer. Human Pathology, 127, pp. 1-11. (doi: 10.1016/j.humpath.2022.05.012) (PMID:35623467)

Patel, M. et al. (2022) Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer. British Journal of Cancer, 126(12), pp. 1704-1714. (doi: 10.1038/s41416-022-01729-2) (PMID:35173303) (PMCID:PMC9174220)

2021

Knight, J. R.P. et al. (2021) MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discovery, 11(5), pp. 1228-1247. (doi: 10.1158/2159-8290.CD-20-0652) (PMID:33328217)

Al-Badran, S. S.F. et al. (2021) Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 7(2), pp. 121-134. (doi: 10.1002/cjp2.193) (PMID:33338327)

2020

Alexander, P.G. et al. (2020) The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer. British Journal of Cancer, 124, pp. 786-796. (doi: 10.1038/s41416-020-01168-x) (PMID:33223535)

2019

Pennel, Kathryn A.F., Park, James H. ORCID: https://orcid.org/0000-0002-6551-2037, McMillan, Donald C. ORCID: https://orcid.org/0000-0003-4260-5334, Roseweir, Antonia K. ORCID: https://orcid.org/0000-0001-6158-1564 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2019) Signal interaction between the tumour and inflammatory cells in patients with gastrointestinal cancer: implications for treatment. Cellular Signalling, 54, pp. 81-90. (doi: 10.1016/j.cellsig.2018.11.013) (PMID:30453014)

Articles

Hillson, L. V.S. et al. (2025) Differential immunological effects of short-course and long-course radiotherapy in locally advanced rectal cancer. Clinical Cancer Research, (Accepted for Publication)

Cammareri, P. et al. (2025) Loss of colonic fidelity enables multilineage plasticity and metastasis. Nature, 644, pp. 547-556. (doi: 10.1038/s41586-025-09125-5) (PMID:40468074) (PMCID:PMC12350155)

Bullock, E. et al. (2025) Cancer-associated fibroblast driven paracrine IL-6/STAT3 signaling promotes migration and dissemination in invasive lobular carcinoma. Breast Cancer Research, 27(1), 121. (doi: 10.1186/s13058-025-02074-x) (PMID:40597443) (PMCID:PMC12219320)

Woraharn, W. et al. (2025) Investigation of three alternative histopathological scoring methods at the invasive tumour front in colorectal cancer. Journal of Pathology: Clinical Research, 11(3), e70031. (doi: 10.1002/2056-4538.70031)

Woolley, C. E. et al. (2025) Coevolution of atypical BRAF and KRAS mutations in colorectal tumorigenesis. Molecular Cancer Research, 23(4), pp. 300-312. (doi: 10.1158/1541-7786.mcr-24-0464) (PMID:39751654) (PMCID:PMC7617415)

Dolan, R. D. et al. (2025) The relationship between tumour necrosis, systemic inflammation, body composition and survival in patients with colon cancer. BJC Reports, 3(1), 7. (doi: 10.1038/s44276-024-00119-w) (PMID:39910331) (PMCID:PMC11799379)

Pennel, K. et al. (2024) IL6 and IL6R as prognostic biomarkers in colorectal cancer. Biomolecules, 14(12), 1629. (doi: 10.3390/biom14121629)

Galbraith, N. J. et al. (2024) TAK1 expression is associated with increased PD-L1 and decreased cancer-specific survival in microsatellite-stable colorectal cancer. Translational Oncology, 48, 102064. (doi: 10.1016/j.tranon.2024.102064) (PMID:39068768)

Knight, Katrina, Bigley, Christopher, Pennel, Kathryn, Hay, Jennifer, Maka, Noori, McMillan, Donald ORCID: https://orcid.org/0000-0003-4260-5334, Park, James ORCID: https://orcid.org/0000-0002-6551-2037, Roxburgh, Campbell ORCID: https://orcid.org/0000-0002-2649-6695 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2024) The Glasgow Microenvironment Score: an exemplar of contemporary biomarker evolution in colorectal cancer. Journal of Pathology: Clinical Research, 10, e12385. (doi: 10.1002/2056-4538.12385) (PMID:38853386)

McKenzie, Molly, Lian, Guang-Yu, Pennel, Kathryn A.F., Quinn, Jean A. ORCID: https://orcid.org/0000-0002-8267-0993, Jamieson, Nigel B. ORCID: https://orcid.org/0000-0002-9552-4725 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2024) NFκB signalling in colorectal cancer: examining the central dogma of IKKα and IKKβ signalling. Heliyon, 10(12), e32904. (doi: 10.1016/j.heliyon.2024.e32904) (PMID:38975078) (PMCID:PMC11226910)

Hatthakarnkul, P. et al. (2024) Histopathological tumour microenvironment score independently predicts outcome in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 10(3), e12374. (doi: 10.1002/2056-4538.12374) (PMID:38650367) (PMCID:PMC11035902)

Pennel, Kathryn, Dutton, Louise ORCID: https://orcid.org/0000-0002-9336-7826, Melissourgou-Syka, Lydia ORCID: https://orcid.org/0000-0002-0926-2328, Roxburgh, Campbell ORCID: https://orcid.org/0000-0002-2649-6695, Birch, Joanna ORCID: https://orcid.org/0000-0001-9522-8435 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2024) Novel radiation and targeted therapy combinations for improving rectal cancer outcomes. Expert Reviews in Molecular Medicine, 26, e14. (doi: 10.1017/erm.2024.15) (PMID:38623751) (PMCID:PMC11140547)

Pennel, K. A.F. et al. (2024) JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors. Journal of Experimental and Clinical Cancer Research, 43, 64. (doi: 10.1186/s13046-024-02958-4) (PMID:38424636) (PMCID:PMC10905886)

Beach, C. et al. (2023) Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. Journal of Clinical Investigation, 133(23), e168277. (doi: 10.1172/JCI168277) (PMID:37824211) (PMCID:PMC10688992)

Greenland, Kyle K., Pennel, Kathryn, Cioccoloni, Giorgia, Rogerson, Connor, Barnieh, Francis M. and Speirs, Valerie (2023) Trailblazers in cancer research: the next generation – the British Association of Cancer Research early-career conference. Biology Open, 12(10), bio060121. (doi: 10.1242/bio.060121) (PMID:37846765) (PMCID:PMC10602000)

Vande Voorde, J. et al. (2023) Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature Metabolism, 5(8), pp. 1303-1318. (doi: 10.1038/s42255-023-00857-0) (PMID:37580540) (PMCID:PMC10447251)

Hatthakarnkul, P. et al. (2023) Protein expression of S100A2 reveals it association with patient prognosis and immune infiltration profile in colorectal cancer. Journal of Cancer, 14(10), pp. 1837-1847. (doi: 10.7150/jca.83910) (PMID:37476187) (PMCID:PMC10355195)

Pennel, Kathryn, Morrow, Elizabeth, Hatthakarnkul, Phimmada, Leslie, Holly ORCID: https://orcid.org/0000-0001-8898-3600, Mallon, Elizabeth, Andersen, Ditte, Jamieson, Nigel ORCID: https://orcid.org/0000-0002-9552-4725, McMillan, Donald ORCID: https://orcid.org/0000-0003-4260-5334, Roseweir, Antonia ORCID: https://orcid.org/0000-0001-6158-1564 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2023) High expression of STAT3 within the tumour-associated stroma predicts poor outcome in breast cancer patients. Cancer Medicine, 12(12), pp. 13225-13240. (doi: 10.1002/cam4.6014) (PMID:37199043) (PMCID:PMC10315752)

Wood, C. S. et al. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83(8), pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794) (PMID:37057593) (PMCID:PMC10102851)

Alexander, P.G., van Wyk, H.C. ORCID: https://orcid.org/0000-0002-4978-5000, Pennel, K.A.F., Hay, J., McMillan, D.C. ORCID: https://orcid.org/0000-0003-4260-5334, Horgan, P.G. ORCID: https://orcid.org/0000-0001-5557-7905, Roxburgh, C.S.D. ORCID: https://orcid.org/0000-0002-2649-6695, Edwards, J. ORCID: https://orcid.org/0000-0002-7192-6906 and Park, J.H. ORCID: https://orcid.org/0000-0002-6551-2037 (2023) The Glasgow Microenvironment Score and risk and site of recurrence in TNM I–III colorectal cancer. British Journal of Cancer, 128(4), pp. 556-567. (doi: 10.1038/s41416-022-02069-x) (PMID:36476660) (PMCID:PMC9938140)

Pennel, K. A. F. et al. (2022) CXCL8 expression is associated with advanced stage, right sidedness, and distinct histological features of colorectal cancer. Journal of Pathology: Clinical Research, 8(6), pp. 509-520. (doi: 10.1002/cjp2.290) (PMID:35879507) (PMCID:PMC9535100)

Alexander, P. G. et al. (2022) The relationship between the Glasgow Microenvironment Score and markers of epithelial-mesenchymal transition in TNM II-III colorectal cancer. Human Pathology, 127, pp. 1-11. (doi: 10.1016/j.humpath.2022.05.012) (PMID:35623467)

Patel, M. et al. (2022) Spatial expression of IKK-alpha is associated with a differential mutational landscape and survival in primary colorectal cancer. British Journal of Cancer, 126(12), pp. 1704-1714. (doi: 10.1038/s41416-022-01729-2) (PMID:35173303) (PMCID:PMC9174220)

Knight, J. R.P. et al. (2021) MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression. Cancer Discovery, 11(5), pp. 1228-1247. (doi: 10.1158/2159-8290.CD-20-0652) (PMID:33328217)

Al-Badran, S. S.F. et al. (2021) Relationship between immune checkpoint proteins, tumour microenvironment characteristics, and prognosis in primary operable colorectal cancer. Journal of Pathology: Clinical Research, 7(2), pp. 121-134. (doi: 10.1002/cjp2.193) (PMID:33338327)

Alexander, P.G. et al. (2020) The Glasgow Microenvironment Score associates with prognosis and adjuvant chemotherapy response in colorectal cancer. British Journal of Cancer, 124, pp. 786-796. (doi: 10.1038/s41416-020-01168-x) (PMID:33223535)

Pennel, Kathryn A.F., Park, James H. ORCID: https://orcid.org/0000-0002-6551-2037, McMillan, Donald C. ORCID: https://orcid.org/0000-0003-4260-5334, Roseweir, Antonia K. ORCID: https://orcid.org/0000-0001-6158-1564 and Edwards, Joanne ORCID: https://orcid.org/0000-0002-7192-6906 (2019) Signal interaction between the tumour and inflammatory cells in patients with gastrointestinal cancer: implications for treatment. Cellular Signalling, 54, pp. 81-90. (doi: 10.1016/j.cellsig.2018.11.013) (PMID:30453014)