2024

Kiourtis, C. et al. (2024) Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nature Cell Biology, (doi: 10.1038/s41556-024-01543-3) (PMID:39537753) (Early Online Publication)

2023

May, S. et al. (2023) Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration. Journal of Hepatology, 78(5), pp. 1028-1036. (doi: 10.1016/j.jhep.2023.01.009) (PMID:36702176)

Villar, V. H. et al. (2023) Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology, 19(3), pp. 292-300. (doi: 10.1038/s41589-022-01154-9) (PMID:36280791) (PMCID:PMC9974483)

May, S. and Bird, T. G. (2023) How the liver keeps itself in shape. eLife, 12, e85606. (doi: 10.7554/elife.85606) (PMID:36729029) (PMCID:PMC9894582)

2022

Leslie, J. et al. (2022) CXCR2 inhibition enables NASH-HCC immunotherapy. Gut, 71(10), pp. 2093-2106. (doi: 10.1136/gutjnl-2021-326259) (PMID:35477863) (PMCID:PMC9484388)

Müller, M. et al. (2022) Human-correlated genetic HCC models identify combination therapy for precision medicine [Pre-print]. Research Square, (doi: 10.21203/rs.3.rs-1638504/v1)

Humpton, T. J., Hall, H., Kiourtis, C. , Nixon, C., Clark, W., Hedley, A., Shaw, R., Bird, T. G., Blyth, K. and Vousden, K. H. (2022) p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl₄. Cell Death and Differentiation, 29(3), pp. 514-526. (doi: 10.1038/s41418-021-00871-3) (PMID:34628485) (PMCID:PMC8901761)

Humpton, T. J. et al. (2022) A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo. Science Signaling, 15(720), eabd9099. (doi: 10.1126/scisignal.abd9099) (PMID:35133863) (PMCID:PMC7612476)

2021

Kiourtis, C. , Wilczynska, A., Nixon, C., Clark, W., May, S. and Bird, T. G. (2021) Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice. Biology Open, 10(9), bio058678. (doi: 10.1242/bio.058678) (PMID:34435198) (PMCID:PMC8487635)

Haq, M. I. et al. (2021) Effect of hepatocellular carcinoma surveillance programmes on overall survival in a mixed cirrhotic UK population: a prospective, longitudinal cohort study. Journal of Clinical Medicine, 10(13), 2770. (doi: 10.3390/jcm10132770) (PMID:34202593) (PMCID:PMC8269358)

Barthet, V. J.A. et al. (2021) Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver. Science Advances, 7(23), eabf9141. (doi: 10.1126/sciadv.abf9141) (PMID:34088666)

Müller, M., May, S. and Bird, T. G. (2021) Ploidy dynamics increase the risk of liver cancer initiation. Nature Communications, 12, 1896. (doi: 10.1038/s41467-021-21897-8) (PMID:33767143) (PMCID:PMC7994546)

2020

Vizioli, M. G. et al. (2020) Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence. Genes and Development, 34(5-6), pp. 428-445. (doi: 10.1101/gad.331272.119) (PMID:32001510) (PMCID:PMC7050483)

2019

Liko, D. et al. (2019) Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. Cell Death and Differentiation, 26(12), pp. 2535-2550. (doi: 10.1038/s41418-019-0316-7) (PMID:30858608) (PMCID:PMC6861133)

Teo, Y. V. et al. (2019) Notch signaling mediates secondary senescence. Cell Reports, 27(4), 997-1007.e5. (doi: 10.1016/j.celrep.2019.03.104) (PMID:31018144) (PMCID:PMC6486482)

Gay, D. M. et al. (2019) Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer. Nature Communications, 10, 723. (doi: 10.1038/s41467-019-08586-3) (PMID:30760720) (PMCID:PMC6374445)

2018

Bird, T. G. et al. (2018) TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science Translational Medicine, 10(454), eaan1230. (doi: 10.1126/scitranslmed.aan1230) (PMID:30111642) (PMCID:PMC6420144)

Articles

Kiourtis, C. et al. (2024) Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ. Nature Cell Biology, (doi: 10.1038/s41556-024-01543-3) (PMID:39537753) (Early Online Publication)

May, S. et al. (2023) Absent expansion of AXIN2+ hepatocytes and altered physiology in Axin2CreERT2 mice challenges the role of pericentral hepatocytes in homeostatic liver regeneration. Journal of Hepatology, 78(5), pp. 1028-1036. (doi: 10.1016/j.jhep.2023.01.009) (PMID:36702176)

Villar, V. H. et al. (2023) Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer. Nature Chemical Biology, 19(3), pp. 292-300. (doi: 10.1038/s41589-022-01154-9) (PMID:36280791) (PMCID:PMC9974483)

May, S. and Bird, T. G. (2023) How the liver keeps itself in shape. eLife, 12, e85606. (doi: 10.7554/elife.85606) (PMID:36729029) (PMCID:PMC9894582)

Leslie, J. et al. (2022) CXCR2 inhibition enables NASH-HCC immunotherapy. Gut, 71(10), pp. 2093-2106. (doi: 10.1136/gutjnl-2021-326259) (PMID:35477863) (PMCID:PMC9484388)

Müller, M. et al. (2022) Human-correlated genetic HCC models identify combination therapy for precision medicine [Pre-print]. Research Square, (doi: 10.21203/rs.3.rs-1638504/v1)

Humpton, T. J., Hall, H., Kiourtis, C. , Nixon, C., Clark, W., Hedley, A., Shaw, R., Bird, T. G., Blyth, K. and Vousden, K. H. (2022) p53-mediated redox control promotes liver regeneration and maintains liver function in response to CCl₄. Cell Death and Differentiation, 29(3), pp. 514-526. (doi: 10.1038/s41418-021-00871-3) (PMID:34628485) (PMCID:PMC8901761)

Humpton, T. J. et al. (2022) A noninvasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo. Science Signaling, 15(720), eabd9099. (doi: 10.1126/scisignal.abd9099) (PMID:35133863) (PMCID:PMC7612476)

Kiourtis, C. , Wilczynska, A., Nixon, C., Clark, W., May, S. and Bird, T. G. (2021) Specificity and off-target effects of AAV8-TBG viral vectors for the manipulation of hepatocellular gene expression in mice. Biology Open, 10(9), bio058678. (doi: 10.1242/bio.058678) (PMID:34435198) (PMCID:PMC8487635)

Haq, M. I. et al. (2021) Effect of hepatocellular carcinoma surveillance programmes on overall survival in a mixed cirrhotic UK population: a prospective, longitudinal cohort study. Journal of Clinical Medicine, 10(13), 2770. (doi: 10.3390/jcm10132770) (PMID:34202593) (PMCID:PMC8269358)

Barthet, V. J.A. et al. (2021) Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver. Science Advances, 7(23), eabf9141. (doi: 10.1126/sciadv.abf9141) (PMID:34088666)

Müller, M., May, S. and Bird, T. G. (2021) Ploidy dynamics increase the risk of liver cancer initiation. Nature Communications, 12, 1896. (doi: 10.1038/s41467-021-21897-8) (PMID:33767143) (PMCID:PMC7994546)

Vizioli, M. G. et al. (2020) Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence. Genes and Development, 34(5-6), pp. 428-445. (doi: 10.1101/gad.331272.119) (PMID:32001510) (PMCID:PMC7050483)

Liko, D. et al. (2019) Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. Cell Death and Differentiation, 26(12), pp. 2535-2550. (doi: 10.1038/s41418-019-0316-7) (PMID:30858608) (PMCID:PMC6861133)

Teo, Y. V. et al. (2019) Notch signaling mediates secondary senescence. Cell Reports, 27(4), 997-1007.e5. (doi: 10.1016/j.celrep.2019.03.104) (PMID:31018144) (PMCID:PMC6486482)

Gay, D. M. et al. (2019) Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer. Nature Communications, 10, 723. (doi: 10.1038/s41467-019-08586-3) (PMID:30760720) (PMCID:PMC6374445)

Bird, T. G. et al. (2018) TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Science Translational Medicine, 10(454), eaan1230. (doi: 10.1126/scitranslmed.aan1230) (PMID:30111642) (PMCID:PMC6420144)