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email:
Alison.McCaig@glasgow.ac.uk
R319 Level 3, Paul O'Gorman Research Centre, Gartnavel General Hospital, Glasgow G11 0YN
Cosimo, E. et al. (2019) AKT/mTORC2 inhibition activates FOXO1 function in CLL cells reducing B cell receptor-mediated survival. Clinical Cancer Research, 25(5), pp. 1574-1587. (doi: 10.1158/1078-0432.CCR-18-2036) (PMID:30559170) (PMCID:PMC6398589)
Nakagawa, R. et al. (2015) Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKC subversion induces up-regulation of PKC II expression in B lymphocytes. Haematologica, 100(4), pp. 499-510. (doi: 10.3324/haematol.2014.112276) (PMID:25616575) (PMCID:PMC4380723)
Middleton, O., Cosimo, E., Dobbin, E., McCaig, A.M., Clarke, C., Brant, A.M., Leach, M.T., Michie, A.M. and Wheadon, H. (2015) Complement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLL. Leukemia, 29(1), pp. 107-114. (doi: 10.1038/leu.2014.146) (PMID:24787488)
Cosimo, E. et al. (2013) Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells. Clinical Cancer Research, 19(9), pp. 2393-2405. (doi: 10.1158/1078-0432.CCR-12-2170)
McCaig, A. M., Cosimo, E., Leach, M. T. and Michie, A. M. (2012) Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12. PLoS ONE, 7(11), e48929. (doi: 10.1371/journal.pone.0048929) (PMID:23133664) (PMCID:PMC3487834)
McCaig, A. M., Cosimo, E., Leach, M. T. and Michie, A. M. (2011) Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals. British Journal of Haematology, 153(2), pp. 199-211. (doi: 10.1111/j.1365-2141.2010.08507.x)
Michie, A. M. , McCaig, A. M., Nakagawa, R. and Vukovic, M. (2010) Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer. FEBS Journal, 277(1), pp. 74-80. (doi: 10.1111/j.1742-4658.2009.07414.x)
Cosimo, E. et al. (2019) AKT/mTORC2 inhibition activates FOXO1 function in CLL cells reducing B cell receptor-mediated survival. Clinical Cancer Research, 25(5), pp. 1574-1587. (doi: 10.1158/1078-0432.CCR-18-2036) (PMID:30559170) (PMCID:PMC6398589)
Nakagawa, R. et al. (2015) Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKC subversion induces up-regulation of PKC II expression in B lymphocytes. Haematologica, 100(4), pp. 499-510. (doi: 10.3324/haematol.2014.112276) (PMID:25616575) (PMCID:PMC4380723)
Middleton, O., Cosimo, E., Dobbin, E., McCaig, A.M., Clarke, C., Brant, A.M., Leach, M.T., Michie, A.M. and Wheadon, H. (2015) Complement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLL. Leukemia, 29(1), pp. 107-114. (doi: 10.1038/leu.2014.146) (PMID:24787488)
Cosimo, E. et al. (2013) Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells. Clinical Cancer Research, 19(9), pp. 2393-2405. (doi: 10.1158/1078-0432.CCR-12-2170)
McCaig, A. M., Cosimo, E., Leach, M. T. and Michie, A. M. (2012) Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12. PLoS ONE, 7(11), e48929. (doi: 10.1371/journal.pone.0048929) (PMID:23133664) (PMCID:PMC3487834)
McCaig, A. M., Cosimo, E., Leach, M. T. and Michie, A. M. (2011) Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals. British Journal of Haematology, 153(2), pp. 199-211. (doi: 10.1111/j.1365-2141.2010.08507.x)
Michie, A. M. , McCaig, A. M., Nakagawa, R. and Vukovic, M. (2010) Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer. FEBS Journal, 277(1), pp. 74-80. (doi: 10.1111/j.1742-4658.2009.07414.x)