The University of Glasgow uses cookies for analytics. Find out more about our Privacy policy.
Necessary cookies enable core functionality. The website cannot function properly without these cookies, and can only be disabled by changing your browser preferences.
Analytical cookies help us improve our website. We use Google Analytics. All data is anonymised.
Clarity helps us to understand our users’ behaviour by visually representing their clicks, taps and scrolling. All data is anonymised.
telephone:
01413302679
email:
Eric.Kalkman@glasgow.ac.uk
Wolfson Wohl Cancer Research Centre, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1QH, G61 1QH
Khalaf, A. et al. (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16(751), eadi5336. (doi: 10.1126/scitranslmed.adi5336) (PMID:38865484)
Rattigan, K. M. et al. (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24, e56279. (doi: 10.15252/embr.202256279) (PMID:37489735) (PMCID:PMC10561355)
Rattigan, K. M. et al. (2023) Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells. Nature Communications, 14, 4634. (doi: 10.1038/s41467-023-40222-z) (PMID:37591854) (PMCID:PMC10435520)
Ianniciello, A. et al. (2021) ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy. Science Translational Medicine, 13(613), eabd5016. (doi: 10.1126/scitranslmed.abd5016) (PMID:34586834)
Natto, M. J., Hulpia, F., Kalkman, E. R., Baillie, S., Alhejely, A., Miyamoto, Y., Eckmann, L., Van Calenbergh, S. and de Koning, H. P. (2021) Deazapurine nucleoside analogues for the treatment of Trichomonas vaginalis. ACS Infectious Diseases, 7(6), pp. 1752-1764. (doi: 10.1021/acsinfecdis.1c00075) (PMID:33974405)
Lote, H. et al. (2017) Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer. Annals of Oncology, 28(6), pp. 1243-1249. (doi: 10.1093/annonc/mdx074) (PMID:28327965) (PMCID:PMC5452067)
Duffy, M. R., Parker, A. L., Kalkman, E. R., White, K., Kovalskyy, D., Kelly, S. M. and Baker, A. H. (2013) Identification of novel small molecule inhibitors of adenovirus gene transfer using a high throughput screening approach. Journal of Controlled Release, 170(1), pp. 132-140. (doi: 10.1016/j.jconrel.2013.05.007)
Duffy, M.R., Kalkman, E. and Baker, A.H. (2012) Identification of a novel small molecule inhibitor of FX-mediated Ad5 gene transfer for gene therapy applications. Molecular Therapy, 20(S1), S117-S117. (doi: 10.1038/mt.2012.86)
Khalaf, A. et al. (2024) Nutrient-sensitizing drug repurposing screen identifies lomerizine as a mitochondrial metabolism inhibitor of chronic myeloid leukemia. Science Translational Medicine, 16(751), eadi5336. (doi: 10.1126/scitranslmed.adi5336) (PMID:38865484)
Rattigan, K. M. et al. (2023) Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO Reports, 24, e56279. (doi: 10.15252/embr.202256279) (PMID:37489735) (PMCID:PMC10561355)
Rattigan, K. M. et al. (2023) Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells. Nature Communications, 14, 4634. (doi: 10.1038/s41467-023-40222-z) (PMID:37591854) (PMCID:PMC10435520)
Ianniciello, A. et al. (2021) ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy. Science Translational Medicine, 13(613), eabd5016. (doi: 10.1126/scitranslmed.abd5016) (PMID:34586834)
Natto, M. J., Hulpia, F., Kalkman, E. R., Baillie, S., Alhejely, A., Miyamoto, Y., Eckmann, L., Van Calenbergh, S. and de Koning, H. P. (2021) Deazapurine nucleoside analogues for the treatment of Trichomonas vaginalis. ACS Infectious Diseases, 7(6), pp. 1752-1764. (doi: 10.1021/acsinfecdis.1c00075) (PMID:33974405)
Lote, H. et al. (2017) Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer. Annals of Oncology, 28(6), pp. 1243-1249. (doi: 10.1093/annonc/mdx074) (PMID:28327965) (PMCID:PMC5452067)
Duffy, M. R., Parker, A. L., Kalkman, E. R., White, K., Kovalskyy, D., Kelly, S. M. and Baker, A. H. (2013) Identification of novel small molecule inhibitors of adenovirus gene transfer using a high throughput screening approach. Journal of Controlled Release, 170(1), pp. 132-140. (doi: 10.1016/j.jconrel.2013.05.007)
Duffy, M.R., Kalkman, E. and Baker, A.H. (2012) Identification of a novel small molecule inhibitor of FX-mediated Ad5 gene transfer for gene therapy applications. Molecular Therapy, 20(S1), S117-S117. (doi: 10.1038/mt.2012.86)