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email:
j.bower@beatson.gla.ac.uk
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, G61 1BD
Yelland, T. et al. (2022) Stabilization of the RAS:PDE6D complex is a novel strategy to inhibit RAS signaling. Journal of Medicinal Chemistry, 65(3), pp. 1898-1914. (doi: 10.1021/acs.jmedchem.1c01265) (PMID:35104933) (PMCID:PMC8842248)
Konczal, J., Bower, J. and Gray, C. H. (2019) Re-introducing non-optimal synonymous codons into codon-optimized constructs enhances soluble recovery of recombinant proteins from Escherichia coli. PLoS ONE, 14(4), e0215892. (doi: 10.1371/journal.pone.0215892) (PMID:31013332) (PMCID:PMC6478350)
Francis, S. et al. (2019) Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorganic and Medicinal Chemistry Letters, 29(8), pp. 1023-1029. (doi: 10.1016/j.bmcl.2019.01.035) (PMID:30773430) (PMCID:PMC6419574)
Birch, J. L. et al. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78(22), pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697) (PMID:30279244)
Unbekandt, M. et al. (2018) Discovery of potent and selective MRCK inhibitors with therapeutic effect on skin cancer. Cancer Research, 78(8), pp. 2096-2114. (doi: 10.1158/0008-5472.CAN-17-2870) (PMID:29382705) (PMCID:PMC5901721)
Gray, C. H., Konczal, J., Mezna, M., Ismail, S. , Bower, J. and Drysdale, M. (2017) A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB. Protein Expression and Purification, 132, pp. 75-84. (doi: 10.1016/j.pep.2017.01.010) (PMID:28137655) (PMCID:PMC5415301)
Bilsland, A. E. et al. (2015) Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. Neoplasia, 17(9), pp. 704-715. (doi: 10.1016/j.neo.2015.08.009) (PMID:26476078) (PMCID:PMC4611071)
Unbekandt, M. et al. (2014) A novel small-molecule MRCK inhibitor blocks cancer cell invasion. Cell Communication and Signaling, 12, 54. (doi: 10.1186/s12964-014-0054-x) (PMID:25288205) (PMCID:PMC4195943)
Morley, A.D. et al. (2013) Fragment-based hit identification: thinking in 3D. Drug Discovery Today, 18(23-24), pp. 1221-1227. (doi: 10.1016/j.drudis.2013.07.011)
Bower, J.F. and Pannifer, A. (2012) Using fragment-based technologies to target protein-protein interactions. Current Pharmaceutical Design, 18(30), pp. 4685-4696.
Yelland, T. et al. (2022) Stabilization of the RAS:PDE6D complex is a novel strategy to inhibit RAS signaling. Journal of Medicinal Chemistry, 65(3), pp. 1898-1914. (doi: 10.1021/acs.jmedchem.1c01265) (PMID:35104933) (PMCID:PMC8842248)
Konczal, J., Bower, J. and Gray, C. H. (2019) Re-introducing non-optimal synonymous codons into codon-optimized constructs enhances soluble recovery of recombinant proteins from Escherichia coli. PLoS ONE, 14(4), e0215892. (doi: 10.1371/journal.pone.0215892) (PMID:31013332) (PMCID:PMC6478350)
Francis, S. et al. (2019) Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorganic and Medicinal Chemistry Letters, 29(8), pp. 1023-1029. (doi: 10.1016/j.bmcl.2019.01.035) (PMID:30773430) (PMCID:PMC6419574)
Birch, J. L. et al. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78(22), pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697) (PMID:30279244)
Unbekandt, M. et al. (2018) Discovery of potent and selective MRCK inhibitors with therapeutic effect on skin cancer. Cancer Research, 78(8), pp. 2096-2114. (doi: 10.1158/0008-5472.CAN-17-2870) (PMID:29382705) (PMCID:PMC5901721)
Gray, C. H., Konczal, J., Mezna, M., Ismail, S. , Bower, J. and Drysdale, M. (2017) A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB. Protein Expression and Purification, 132, pp. 75-84. (doi: 10.1016/j.pep.2017.01.010) (PMID:28137655) (PMCID:PMC5415301)
Bilsland, A. E. et al. (2015) Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. Neoplasia, 17(9), pp. 704-715. (doi: 10.1016/j.neo.2015.08.009) (PMID:26476078) (PMCID:PMC4611071)
Unbekandt, M. et al. (2014) A novel small-molecule MRCK inhibitor blocks cancer cell invasion. Cell Communication and Signaling, 12, 54. (doi: 10.1186/s12964-014-0054-x) (PMID:25288205) (PMCID:PMC4195943)
Morley, A.D. et al. (2013) Fragment-based hit identification: thinking in 3D. Drug Discovery Today, 18(23-24), pp. 1221-1227. (doi: 10.1016/j.drudis.2013.07.011)
Bower, J.F. and Pannifer, A. (2012) Using fragment-based technologies to target protein-protein interactions. Current Pharmaceutical Design, 18(30), pp. 4685-4696.
Bilsland, A., Pugliese, A., Liu, Y., Revie, J., Burns, S., McCormick, C., Cairney, C., Bower, J., Drysdale, M., Narita, M., Sadaie, M. and Keith, N. (2015) Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. [Data Collection]