Number of items: 40.
2024
Donnelly, H. et al.
(2024)
Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells.
Nature Communications, 15,
5791.
(doi: 10.1038/s41467-024-50054-0)
Busch, C., Nyamondo, K. and Wheadon, H.
(2024)
Complexities of modelling the bone marrow microenvironment to facilitate haematopoietic research.
Experimental Hematology, 135,
104233.
(doi: 10.1016/j.exphem.2024.104233)
(PMID:38740324)
Dawson, A. et al.
(2024)
Leukaemia exposure alters the transcriptional profile and function of BCR::ABL1 negative macrophages in the bone marrow niche.
Nature Communications, 15,
1090.
(doi: 10.1038/s41467-024-45471-0)
(PMID:38316788)
(PMCID:PMC10844594)
Nyamondo, K. and Wheadon, H.
(2024)
Microenvironment alterations through time leading to myeloid malignancies.
British Journal of Pharmacology, 181(2),
pp. 283-294.
(doi: 10.1111/bph.15924)
(PMID:35844165)
2023
Busch, C., Mulholland, T., Zagnoni, M., Dalby, M. , Berry, C. and Wheadon, H.
(2023)
Overcoming BCR::ABL1 dependent and independent survival mechanisms in chronic myeloid leukaemia using a multi-kinase targeting approach.
Cell Communication and Signaling, 21,
342.
(doi: 10.1186/s12964-023-01363-2)
(PMID:38031192)
(PMCID:PMC10685629)
Zarou, M. M. et al.
(2023)
Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche.
65th ASH Annual Meeting and Exposition, San Diego, California, USA, 09-12 Dec 2023.
(doi: 10.1182/blood-2023-181630)
2022
Parry, N., Busch, C., Aßmann, V., Cassels, J., Hair, A., Helgason, G. V. , Wheadon, H. and Copland, M.
(2022)
BH3 mimetics in combination with nilotinib or ponatinib represent a promising therapeutic strategy in blast phase chronic myeloid leukemia.
Cell Death Discovery, 8,
457.
(doi: 10.1038/s41420-022-01211-1)
(PMID:36379918)
(PMCID:PMC9666353)
Pancheva, A., Wheadon, H. , Rogers, S. and Otto, T. D.
(2022)
Using topic modeling to detect cellular crosstalk in scRNA-seq.
PLoS Computational Biology, 18(4),
e1009975.
(doi: 10.1371/journal.pcbi.1009975)
(PMID:35395014)
(PMCID:PMC9064087)
2021
Chantkran, W., Hsieh, Y.-C., Zheleva, D., Frame, S., Wheadon, H. and Copland, M.
(2021)
Interrogation of novel CDK2/9 inhibitor fadraciclib (CYC065) as a potential therapeutic approach for AML.
Cell Death Discovery, 7,
137.
(doi: 10.1038/s41420-021-00496-y)
(PMID:34112754)
(PMCID:PMC8192769)
Parry, N., Wheadon, H. and Copland, M.
(2021)
The application of BH3 mimetics in myeloid leukemias.
Cell Death and Disease, 12,
222.
(doi: 10.1038/s41419-021-03500-6)
(PMID:33637708)
(PMCID:PMC7908010)
2020
McAllister, M., Constancio, V., Patek, S., Gan, H., Bailey, P. , Wheadon, H. , Underwood, M., Leung, H. and Edwards, J.
(2020)
Inflammatory infiltration is associated with AR expression and poor prognosis in hormone naïve prostate cancer.
Prostate, 80(15),
pp. 1353-1364.
(doi: 10.1002/pros.24064)
(PMID:32846021)
Kinstrie, R. et al.
(2020)
CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy.
Leukemia, 34(6),
pp. 1613-1625.
(doi: 10.1038/s41375-019-0684-5)
(PMID:31896780)
(PMCID:PMC7272220)
2019
Wheadon, H. and Busch, C.
(2019)
Bone marrow niche crosses paths with BMPs: a road to protection and persistence in CML.
Biochemical Society Transactions, 47(5),
pp. 1307-1325.
(doi: 10.1042/BST20190221)
(PMID:31551354)
2018
Toofan, P., Busch, C., Morrison, H., O'Brien, S., Jørgensen, H. , Copland, M. and Wheadon, H.
(2018)
Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal.
Cell Death and Disease, 9,
927.
(doi: 10.1038/s41419-018-0905-2)
(PMID:30206237)
(PMCID:PMC6134087)
2017
Biggs, M. J.P. et al.
(2017)
The functional response of mesenchymal stem cells to electron-beam patterned elastomeric surfaces presenting micrometer to nanoscale heterogeneous rigidity.
Advanced Materials, 29(39),
1702119.
(doi: 10.1002/adma.201702119)
(PMID:28861921)
Lewis, N. S., Lewis, E. E.L., Mullin, M., Wheadon, H. , Dalby, M. J. and Berry, C. C.
(2017)
Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence.
Journal of Tissue Engineering, 8,
pp. 1-11.
(doi: 10.1177/2041731417704428)
(PMID:28616152)
(PMCID:PMC5460809)
2016
Horne, G. A. , Morrison, H., Campbell, V., Kinstrie, R., Cassels, J., Hair, A., Vetrie, D. , Wheadon, H. , Holyoake, T. L. and Copland, M.
(2016)
Notch Pathway Activation Targets Leukemic Stem Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML).
American Society of Hematology 58th Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.
Chaudhury, S. S. , Wheadon, H. , Gibson, B. and Keeshan, K.
(2016)
The Bone Marrow Niche Distinguishes Young and Old Leukemia.
58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.
Toofan, P. and Wheadon, H.
(2016)
Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis.
Biochemical Society Transactions, 44(5),
pp. 1455-1463.
(doi: 10.1042/BST20160104)
(PMID:27911727)
Lewis, E. E. L., Wheadon, H. , Lewis, N., Yang, J., Mullin, M., Hursthouse, A., Stirling, D., Dalby, M. J. and Berry, C. C.
(2016)
A quiescent, regeneration-responsive tissue engineered mesenchymal stem cell bone marrow niche model via magnetic levitation.
ACS Nano, 10(9),
pp. 8346-8354.
(doi: 10.1021/acsnano.6b02841)
(PMID:27602872)
Middleton, O., Wheadon, H. and Michie, A.
(2016)
Classical complement pathway.
In: Ratcliffe, M.J.H. (ed.)
Encyclopedia of Immunobiology, 1st Edition.
Elsevier: New York, NY.
ISBN 9780123742797
(doi: 10.1016/B978-0-12-374279-7.02014-2)
Irvine, D. A. et al.
(2016)
Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia.
Scientific Reports, 6,
25476.
(doi: 10.1038/srep25476)
(PMID:27157927)
(PMCID:PMC4860619)
2015
Ford, C. A. et al.
(2015)
Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma.
Current Biology, 25(5),
pp. 577-588.
(doi: 10.1016/j.cub.2014.12.059)
(PMID:25702581)
(PMCID:PMC4353688)
Kranc, K. R. et al.
(2015)
Acute loss of Cited2 impairs Nanog expression and decreases self-renewal of mouse embryonic stem cells.
Stem Cells, 33(3),
pp. 699-712.
(doi: 10.1002/stem.1889)
(PMID:25377420)
Middleton, O., Cosimo, E., Dobbin, E., McCaig, A.M., Clarke, C., Brant, A.M., Leach, M.T., Michie, A.M. and Wheadon, H.
(2015)
Complement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLL.
Leukemia, 29(1),
pp. 107-114.
(doi: 10.1038/leu.2014.146)
(PMID:24787488)
2014
Gallipoli, P., Cook, A., Rhodes, S. , Hopcroft, L. , Wheadon, H. , Whetton, A. D., Jorgensen, H. G. , Bhatia, R. and Holyoake, T. L.
(2014)
JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo.
Blood, 124(9),
pp. 1492-1501.
(doi: 10.1182/blood-2013-12-545640)
(PMID:24957147)
(PMCID:PMC4148771)
Toofan, P., Irvine, D., Hopcroft, L. , Copland, M. and Wheadon, H.
(2014)
The role of the bone morphogenetic proteins in leukaemic stem cell persistence.
Biochemical Society Transactions, 42(4),
pp. 809-815.
(doi: 10.1042/BST20140037)
2013
Cosimo, E. et al.
(2013)
Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells.
Clinical Cancer Research, 19(9),
pp. 2393-2405.
(doi: 10.1158/1078-0432.CCR-12-2170)
Rhodes, S. , Copland, M. , Hopcroft, L. , Sayeski, P. and Wheadon, H.
(2013)
Identification of JAK2 dependent transcriptional regulators in CML.
In: 42nd Annual Scientific Meeting of the ISEH – Society for Hematology and Stem Cells, Vienna, Austria, 22-25 Aug 2013,
S47-S47.
Sands, W.A., Copland, M. and Wheadon, H.
(2013)
Targeting self-renewal pathways in myeloid malignancies.
Cell Communication and Signaling, 11(33),
(doi: 10.1186/1478-811X-11-33)
Tarafdar, A., Dobbin, E., Corrigan, P., Freeburn, R. and Wheadon, H.
(2013)
Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation.
PLoS ONE, 8(11),
e81030.
(doi: 10.1371/journal.pone.0081030)
(PMID:24324557)
(PMCID:PMC3850021)
2011
Wheadon, H. , Ramsey, J.M., Dobbin, E., Dickson, G.J., Corrigan, P.M., Freeburn, R.W. and Thompson, A.
(2011)
Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis.
Stem Cells and Development, 20(8),
pp. 1465-1476.
(doi: 10.1089/scd.2010.0226)
2010
Dobbin, E., Graham, C., Freeburn, R.W., Unwin, R.D., Griffiths, J.R., Pierce, A., Whetton, A.D. and Wheadon, H.
(2010)
Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways.
Stem Cell Research, 5(3),
pp. 226-243.
(doi: 10.1016/j.scr.2010.08.001)
2009
Dobbin, E., Graham, C., Corrigan, P., Thomas, K., Freeburn, R. and Wheadon, H.
(2009)
Tel/PDGFRβ induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways.
Experimental Hematology, 37(1),
pp. 111-121.
(doi: 10.1016/j.exphem.2008.09.012)
Corrigan, P.M., Dobbin, E., Freeburn, R.W. and Wheadon, H.
(2009)
Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.
Stem Cells and Development, 18(5),
pp. 759-771.
(doi: 10.1089/scd.2008.0270)
2008
Dobbin, E., Corrigan, P.M., Walsh, C.P., Welham, M.J., Freeburn, R.W. and Wheadon, H.
(2008)
Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells.
Leukemia Research, 32(10),
pp. 1554-1564.
(doi: 10.1016/j.leukres.2008.02.007)
2004
Paling, N.R.D., Wheadon, H. , Bone, H.K. and Welham, M.J.
(2004)
Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling.
Journal of Biological Chemistry, 279(46),
pp. 48063-48070.
(doi: 10.1074/jbc.M406467200)
2003
Wheadon, H. , Edmead, C. and Welham, M.J.
(2003)
Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2).
Biochemical Journal, 376(1),
pp. 147-157.
(doi: 10.1042/BJ20031160)
Wheadon, H. and Welham, M.J.
(2003)
The coupling of TEL/PDGF R to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases.
Blood, 102(4),
pp. 1480-1489.
(doi: 10.1182/blood-2002-09-2974)
2002
Wheadon, H. , Paling, N.R.D. and Welham, M.J.
(2002)
Molecular interactions of SHP1 and SHP2 in IL-3-signalling.
Cellular Signalling, 14(3),
pp. 219-229.
(doi: 10.1016/S0898-6568(01)00241-8)
This list was generated on Fri Aug 16 13:45:28 2024 BST.