2024

Apps, J. et al. (2024) A review calling for research directed at early detection of childhood cancers: the clinical, scientific, and economic arguments for population screening and surveillance. EJC Paediatric Oncology, (Accepted for Publication)

Anastasopoulou, S. et al. (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, (doi: 10.1111/bjh.19610) (PMID:38924051) (Early Online Publication)

2022

Cousins, A. et al. (2022) Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways. Leukemia, 36(12), pp. 2903-2907. (doi: 10.1038/s41375-022-01722-x) (PMID:36289348) (PMCID:PMC9712090)

Thastrup, M., Duguid, A., Mirian, C., Schmiegelow, K. and Halsey, C. (2022) Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions. Leukemia, 36(12), pp. 2751-2768. (doi: 10.1038/s41375-022-01714-x) (PMID:36266325)

Pal, D. et al. (2022) hiPSC-derived bone marrow milieu identifies a clinically actionable driver of niche-mediated treatment resistance in leukemia. Cell Reports Medicine, 3(8), 100717. (doi: 10.1016/j.xcrm.2022.100717) (PMID:35977468) (PMCID:PMC9418860)

2021

Malouf, C., Antunes, E. T.B., O'Dwyer, M., Jakobczyk, H., Sahm, F., Landua, S.-L., Anderson, R. A., Soufi, A., Halsey, C. and Ottersbach, K. (2021) MiR-130b and miR-128a are essential lineage-specific co-drivers of t(4;11) MLL-AF4 acute leukemia. Blood, 138(21), pp. 2066-2092. (doi: 10.1182/blood.2020006610) (PMID:34111240)

Rice, S. et al. (2021) A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program. Nature Communications, 12, 6905. (doi: 10.1038/s41467-021-27270-z) (PMID:34824279) (PMCID:PMC8616957)

Zanetti, C. et al. (2021) The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukemia progression via CXCR5-CXCL13. Blood, 138(19), pp. 1870-1884. (doi: 10.1182/blood.2021011557) (PMID:34424946)

Halsey, C. and Escherich, G. (2021) A “Goldilocks” approach to CNS leukaemia is needed. Blood, 138(4), pp. 288-289. (doi: 10.1182/blood.2021011461) (PMID:34323942)

Andrés-Jensen, L. et al. (2021) Severe toxicity free survival: physician-derived definitions of unacceptable long-term toxicities following acute lymphocytic leukaemia. Lancet Haematology, 8(7), e513-e523. (doi: 10.1016/S2352-3026(21)00136-8) (PMID:34171282)

Welisch, G. et al. (2021) First in Human: who and what makes a cancer phase 1 trial and why are they so important? Project Report. OSF. (doi: 10.17605/OSF.IO/KWHQF).

Shi, Y. et al. (2021) Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia. Haematologica, 106(4), pp. 1056-1066. (doi: 10.3324/haematol.2019.241026) (PMID:32139432) (PMCID:PMC8018112)

Lenk, L. et al. (2021) CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia. Communications Biology, 4, 73. (doi: 10.1038/s42003-020-01591-z) (PMID:33452446) (PMCID:PMC7810877)

2020

Savino, A. M. et al. (2020) Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on Stearoyl CoA desaturase. Nature Cancer, 1(10), pp. 998-1009. (doi: 10.1038/s43018-020-00115-2) (PMID:33479702) (PMCID:PMC7116605)

Abdelrasoul, H. et al. (2020) Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia. Nature Communications, 11, 3194. (doi: 10.1038/s41467-020-16927-w) (PMID:32581241) (PMCID:PMC7314847)

Walker, D. A., Meijer, L., Coyle, B. and Halsey, C. (2020) Leptomeningeal malignancy of childhood: sharing learning between childhood leukaemia and brain tumour trials. Lancet Child and Adolescent Health, 4(3), pp. 242-250. (doi: 10.1016/S2352-4642(19)30333-5) (PMID:31958415)

Forster, V. J., Bell, G. and Halsey, C. (2020) Should nitrous oxide ever be used in oncology patients receiving methotrexate therapy? Pediatric Anesthesia, 30(1), pp. 9-16. (doi: 10.1111/pan.13760) (PMID:31667903)

2019

Yousafzai, Y. M. et al. (2019) Use of quantitative polymerase chain reaction (qPCR) for the diagnosis and monitoring of CNS leukaemia. Leukemia Research, 87, 10623. (doi: 10.1016/j.leukres.2019.106232) (PMID:31706196)

Matheson, E. C. et al. (2019) Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM. Haematologica, 104(9), pp. 1804-1811. (doi: 10.3324/haematol.2017.185975) (PMID:30655370) (PMCID:PMC6717586)

Baquero, P. et al. (2019) Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia, 33(4), pp. 981-994. (doi: 10.1038/s41375-018-0252-4) (PMID:30185934) (PMCID:PMC6292500)

2018

Alsadeq, A. et al. (2018) IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia. Blood, 132(15), pp. 1614-1617. (doi: 10.1182/blood-2018-04-844209) (PMID:30154115) (PMCID:PMC6238156)

Halsey, C. (2018) Challenging "privileged" stereotypes - leukemic blasts and the central nervous system. Leukemia Research, 73, pp. 76-77. (doi: 10.1016/j.leukres.2018.08.013) (PMID:30243134)

Wilson, R., Osborne, C. and Halsey, C. (2018) The use of Ommaya reservoirs to deliver central nervous system directed chemotherapy in childhood acute lymphoblastic leukaemia. Pediatric Drugs, 20(4), pp. 293-301. (doi: 10.1007/s40272-018-0298-9) (PMID:29850985)

Forster, V., Escherich, G. and Halsey, C. (2018) Comment on: Successful use of nitrous oxide during lumbar punctures: a call for nitrous oxide in pediatric oncology clinics. Pediatric Blood and Cancer, 65(5), e26930. (doi: 10.1002/pbc.26930) (PMID:29286566)

De Santo, C. et al. (2018) The arginine metabolome in Acute Lymphoblastic Leukemia can be targeted by the PEG-recombinant Arginase I BCT-100. International Journal of Cancer, 142(7), pp. 1490-1502. (doi: 10.1002/ijc.31170) (PMID:29168171) (PMCID:PMC5849425)

Sinclair, P. B. et al. (2018) Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. Haematologica, 103(4), pp. 634-644. (doi: 10.3324/haematol.2017.172304) (PMID:29449437) (PMCID:PMC5865429)

Bartram, J., Goulden, N., Wright, G., Adams, S., Brooks, T., Edwards, D., Inglott, S., Yousafzai, Y., Hubank, M. and Halsey, C. (2018) High throughput sequencing in acute lymphoblastic leukemia reveals clonal architecture of central nervous system and bone marrow compartments. Haematologica, 103, e113. (doi: 10.3324/haematol.2017.174987) (PMID:29217777)

2017

Cousins, A. et al. (2017) Upregulated cholesterol biosynthesis is a biomarker for isolated central nervous system relapse in acute lymphoblastic leukaemia. Blood, 130(Sup 1), 3992.

Forster, V. J., van Delft, F. W., Baird, S. F., Mair, S., Skinner, R. and Halsey, C. (2017) Reply: Methotrexate neurotoxicity due to drug interactions: an inadequate folinic acid effect. Cancer Chemotherapy and Pharmacology, 79(4), pp. 841-842. (doi: 10.1007/s00280-017-3270-4) (PMID:28289862)

Cousins, A. F., Olivares, O., Michie, A. M. , Gottlieb, E. and Halsey, C. (2017) Association of CNS Involvement in Childhood Acute Lymphoblastic Leukaemia with Cholesterol Biosynthesis Upregulation. Spring Meeting for Clinician Scientists in Training 2017, London, UK, 23 Feb 2017. S35. (doi: 10.1016/S0140-6736(17)30431-2)

Oruganti, S.R., Torres, D.J., Krebsbach, S., Asperti-Boursin, F., Winters, J., Matlawska-Wasowska, K., Winter, S.S., Halsey, C. and Cannon, J.L. (2017) CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS. Leukemia, 31(1), pp. 255-258. (doi: 10.1038/leu.2016.272) (PMID:27698445)

2016

Forster, V. J., van Delft, F. W., Baird, S. F., Mair, S., Skinner, R. and Halsey, C. (2016) Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients. Cancer Chemotherapy and Pharmacology, 78(5), pp. 1093-1096. (doi: 10.1007/s00280-016-3153-0) (PMID:27659182) (PMCID:PMC5083755)

Schmiegelow, K. et al. (2016) Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus. Lancet Oncology, 17(6), e231-e239. (doi: 10.1016/S1470-2045(16)30035-3)

Williams, M. T.S. et al. (2016) The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukaemia blasts. Blood, 127, 16. (doi: 10.1182/blood-2015-08-665034) (PMID:26869395)

2015

Olivares, O., Däbritz, J. H. M., King, A., Gottlieb, E. and Halsey, C. (2015) Research into cancer metabolomics: towards a clinical metamorphosis. Seminars in Cell and Developmental Biology, 43, pp. 52-64. (doi: 10.1016/j.semcdb.2015.09.008) (PMID:26365277)

2014

Irving, J. et al. (2014) Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition. Blood, 124(23), pp. 3420-3430. (doi: 10.1182/blood-2014-04-531871) (PMID:25253770) (PMCID:PMC4246039)

Winter, S. and Halsey, C. (2014) Should children presenting with iron deficiency anaemia be screened for coeliac disease? Archives of Disease in Childhood, 99(2), pp. 180-182. (doi: 10.1136/archdischild-2013-305591)

El-Fakhri, N., McDevitt, H., Shaikh, M.G., Halsey, C. and Ahmed, S.F. (2014) Vitamin D and its effects on glucose homeostasis, cardiovascular function and immune function. Hormone Research in Paediatrics, 81(6), pp. 363-378. (doi: 10.1159/000357731)

Halsey, C. (2014) Haematological investigations in paediatrics. In: Goal, K.M. and Carachi, R. (eds.) Hutchison's Atlas of Paediatric Physical Diagnosis. Jaypee Brothers Medical Publishers: New Delhi. ISBN 9789351521525

Halsey, C. (2014) Towards personalised medicine in childhood acute lymphoblastic leukaemia. In: Thomas, A.E. and Halsey, C. (eds.) Controversies in Pediatric and Adolescent Hematology. Kerger, pp. 98-115. ISBN 9783318024234 (doi: 10.1159/000350349)

Thomas, A.E. and Halsey, C. (2014) Controversies in Pediatric and Adolescent Hematology. Series: Pediatric and Adolescent Medicine. Karger. ISBN 9783318024227

Williams, M. T.S. et al. (2014) Interleukin-15 enhances cellular proliferation and up-regulates CNS homing molecules in pre-B acute lymphoblastic leukemia. Blood, 123(20), pp. 3116-3127. (doi: 10.1182/blood-2013-05-499970) (PMID:24700781)

2013

Yasar, M. Y. et al. (2013) 3866 An Analysis of Mechanisms of Central Nervous System Infiltration in Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice. 55th ASH Annual Meeting and Exposition, New Orleans, LA, USA, 7-10 Dec 2013.

Roberts, I. et al. (2013) GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia. Blood, 122(24), pp. 3908-3917. (doi: 10.1182/blood-2013-07-515148)

2012

Halsey, C. , Docherty, M., McNeill, M., Gilchrist, D., Le Brocq, M., Gibson, B. and Graham, G. (2012) The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells. Journal of Hematology and Oncology, 5, p. 45. (doi: 10.1186/1756-8722-5-45)

2011

Williams, M.T., Graham, G. , Gibson, B. and Halsey, C. (2011) Homing to the central nervous system is associated with differential expression of selectins, integrins and chemokine receptors in pre-B acute lymphoblastic leukaemia cell lines. In: 51st Annual Scientific Meeting of the British Society for Haematology, Brighton, UK, 4-6 April 2011, pp. 1-88. (doi: 10.1111/j.1365-2141.2011.08609.x)

Williams, M.T., Graham, G. , Gibson, B. and Halsey, C. (2011) An investigation into the role of interleukin-15 on the growth and survival of pre-B acute lymphoblastic leukaemia cell lines. In: 51st Annual Scientific Meeting of the British Society for Haematology, Brighton, UK, 4-6 April 2011, pp. 1-88. (doi: 10.1111/j.1365-2141.2011.08609.x)

Halsey, C. , Buck, G., Richards, S., Vargha-Khadem, F., Hill, F. and Gibson, B. (2011) The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI. Journal of Hematology and Oncology, 4(42), (doi: 10.1186/1756-8722-4-42)

2010

Halsey, C. , Lumley, H. and Luckit, J. (2010) Necrotising external otitis caused by Aspergillus wentii: a case report. Mycoses, 54(4), E211-E213. (doi: 10.1111/J.1439-0507.2009.01815.x)

Halsey, C. , Tunstall, O., Gibson, B., Roberts, I. and Graham, G. (2010) Role of GATA-1s in early hematopoiesis and differences between alternative splicing in human and murine GATA-1. Blood, 115(16), pp. 3415-3416. (doi: 10.1182/blood-2010-02-267930)

2009

Halsey, C. and Chalmers, E.A. (2009) Haematalogical investigations in children. In: Goel, K. and Gupta, D. (eds.) Hutchison's Paediatrics. Jaypee Brothers, Medical Publishers (P) Ltd.. ISBN 9788184485868

2008

McKimmie, C. S. et al. (2008) Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. Journal of Immunology, 181(5), pp. 3353-3363. (doi: 10.4049/jimmunol.181.11.8170-a) (PMID:19039854)

Halsey, C.,. and Chalmers, E.A. (2008) Haematological investigations in paediatrics. In: Goel, K.M. and Gupta, D.K. (eds.) Hutchison's Paediatrics. Jaypee Brothers Medical Publishers: New Delhi. ISBN 9788184485868

Halsey, C. and Roberts, I. (2008) Neonatal Haematology. In: Forfar, J.O. and McIntosh, N. (eds.) Forfar and Arneil's Textbook of Pediatrics. Churchill Livingstone: Edinburgh. ISBN 9780443103971

2007

Halsey, C. , Fisher, C., Strathdee, G., Gibson, B., Holyoake, T., Vyas, P. and Graham, G. (2007) GATA1 mutational analysis in chronic myeloid leukaemia. British Journal of Haematology, 137(4), pp. 375-376. (doi: 10.1111/j.1365-2141.2007.06563.x) (PMID:17408401)

2006

Gibson, B. E.S. and Halsey, C. (2006) Nonimmune neonatal anemias. In: Arceci, R., Hann, I. M. and Smith, O. P. (eds.) Pediatric Hematology. Blackwell Publishing: Malden, pp. 130-150. ISBN 9781405134002 (doi: 10.1002/9780470987001.ch7)

2004

Jiskoot, P.M.C., Halsey, C. , Rivers, R., Bain, B.J. and Wilkins, B.S. (2004) Unusual splenic sinusoidal iron overload in sickle cell/haemoglobin D-Punjab disease. Journal of Clinical Pathology, 57(5), pp. 539-540. (doi: 10.1136/jcp.2002.004481) (PMID:15113864) (PMCID:PMC1770290)

2003

Ronghe, M. D., Halsey, C. and Goulden, N. J. (2003) Anticoagulation therapy in children. Pediatric Drugs, 5(12), pp. 803-820. (doi: 10.2165/00148581-200305120-00004) (PMID:14658922)

Amrolia, P. J., Almeida, A., Halsey, C. , Roberts, I. A. G. and Davies, S. C. (2003) Therapeutic challenges in childhood sickle cell disease part 1: current and future treatment options. British Journal of Haematology, 120(5), pp. 725-736. (doi: 10.1046/j.1365-2141.2003.04143.x) (PMID:12614202)

Halsey, C. and Roberts, I. A.G. (2003) The role of hydroxyurea in sickle cell disease. British Journal of Haematology, 120(2), pp. 177-186. (doi: 10.1046/j.1365-2141.2003.03849.x) (PMID:12542474)

Halsey, C. and Roberts, I. (2003) haemopoietic stem cell transplantation for thalassaemia and sickle cell disease. In: Okpala, I.E. (ed.) Comprehensive Care of Sickle Cell Disease. UNSPECIFIED.

Halsey, C. and Roberts, I. (2003) Neonatal Haematology. In: Forfar, J.O., Arneil, G.C., McIntosh, N., Helms, P. and Smyth, R.L. (eds.) Forfar and Arneil's Textbook of Pediatrics. Churchill Livingstone: Edinburgh. ISBN 9780443071980

Articles

Apps, J. et al. (2024) A review calling for research directed at early detection of childhood cancers: the clinical, scientific, and economic arguments for population screening and surveillance. EJC Paediatric Oncology, (Accepted for Publication)

Anastasopoulou, S. et al. (2024) Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy—An observational Ponte di Legno Toxicity Working Group Study. British Journal of Haematology, (doi: 10.1111/bjh.19610) (PMID:38924051) (Early Online Publication)

Cousins, A. et al. (2022) Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways. Leukemia, 36(12), pp. 2903-2907. (doi: 10.1038/s41375-022-01722-x) (PMID:36289348) (PMCID:PMC9712090)

Thastrup, M., Duguid, A., Mirian, C., Schmiegelow, K. and Halsey, C. (2022) Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions. Leukemia, 36(12), pp. 2751-2768. (doi: 10.1038/s41375-022-01714-x) (PMID:36266325)

Pal, D. et al. (2022) hiPSC-derived bone marrow milieu identifies a clinically actionable driver of niche-mediated treatment resistance in leukemia. Cell Reports Medicine, 3(8), 100717. (doi: 10.1016/j.xcrm.2022.100717) (PMID:35977468) (PMCID:PMC9418860)

Malouf, C., Antunes, E. T.B., O'Dwyer, M., Jakobczyk, H., Sahm, F., Landua, S.-L., Anderson, R. A., Soufi, A., Halsey, C. and Ottersbach, K. (2021) MiR-130b and miR-128a are essential lineage-specific co-drivers of t(4;11) MLL-AF4 acute leukemia. Blood, 138(21), pp. 2066-2092. (doi: 10.1182/blood.2020006610) (PMID:34111240)

Rice, S. et al. (2021) A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program. Nature Communications, 12, 6905. (doi: 10.1038/s41467-021-27270-z) (PMID:34824279) (PMCID:PMC8616957)

Zanetti, C. et al. (2021) The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukemia progression via CXCR5-CXCL13. Blood, 138(19), pp. 1870-1884. (doi: 10.1182/blood.2021011557) (PMID:34424946)

Halsey, C. and Escherich, G. (2021) A “Goldilocks” approach to CNS leukaemia is needed. Blood, 138(4), pp. 288-289. (doi: 10.1182/blood.2021011461) (PMID:34323942)

Andrés-Jensen, L. et al. (2021) Severe toxicity free survival: physician-derived definitions of unacceptable long-term toxicities following acute lymphocytic leukaemia. Lancet Haematology, 8(7), e513-e523. (doi: 10.1016/S2352-3026(21)00136-8) (PMID:34171282)

Shi, Y. et al. (2021) Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia. Haematologica, 106(4), pp. 1056-1066. (doi: 10.3324/haematol.2019.241026) (PMID:32139432) (PMCID:PMC8018112)

Lenk, L. et al. (2021) CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia. Communications Biology, 4, 73. (doi: 10.1038/s42003-020-01591-z) (PMID:33452446) (PMCID:PMC7810877)

Savino, A. M. et al. (2020) Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on Stearoyl CoA desaturase. Nature Cancer, 1(10), pp. 998-1009. (doi: 10.1038/s43018-020-00115-2) (PMID:33479702) (PMCID:PMC7116605)

Abdelrasoul, H. et al. (2020) Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia. Nature Communications, 11, 3194. (doi: 10.1038/s41467-020-16927-w) (PMID:32581241) (PMCID:PMC7314847)

Walker, D. A., Meijer, L., Coyle, B. and Halsey, C. (2020) Leptomeningeal malignancy of childhood: sharing learning between childhood leukaemia and brain tumour trials. Lancet Child and Adolescent Health, 4(3), pp. 242-250. (doi: 10.1016/S2352-4642(19)30333-5) (PMID:31958415)

Forster, V. J., Bell, G. and Halsey, C. (2020) Should nitrous oxide ever be used in oncology patients receiving methotrexate therapy? Pediatric Anesthesia, 30(1), pp. 9-16. (doi: 10.1111/pan.13760) (PMID:31667903)

Yousafzai, Y. M. et al. (2019) Use of quantitative polymerase chain reaction (qPCR) for the diagnosis and monitoring of CNS leukaemia. Leukemia Research, 87, 10623. (doi: 10.1016/j.leukres.2019.106232) (PMID:31706196)

Matheson, E. C. et al. (2019) Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM. Haematologica, 104(9), pp. 1804-1811. (doi: 10.3324/haematol.2017.185975) (PMID:30655370) (PMCID:PMC6717586)

Baquero, P. et al. (2019) Targeting quiescent leukemic stem cells using second generation autophagy inhibitors. Leukemia, 33(4), pp. 981-994. (doi: 10.1038/s41375-018-0252-4) (PMID:30185934) (PMCID:PMC6292500)

Alsadeq, A. et al. (2018) IL7R is associated with CNS infiltration and relapse in pediatric B-cell precursor acute lymphoblastic leukemia. Blood, 132(15), pp. 1614-1617. (doi: 10.1182/blood-2018-04-844209) (PMID:30154115) (PMCID:PMC6238156)

Halsey, C. (2018) Challenging "privileged" stereotypes - leukemic blasts and the central nervous system. Leukemia Research, 73, pp. 76-77. (doi: 10.1016/j.leukres.2018.08.013) (PMID:30243134)

Wilson, R., Osborne, C. and Halsey, C. (2018) The use of Ommaya reservoirs to deliver central nervous system directed chemotherapy in childhood acute lymphoblastic leukaemia. Pediatric Drugs, 20(4), pp. 293-301. (doi: 10.1007/s40272-018-0298-9) (PMID:29850985)

Forster, V., Escherich, G. and Halsey, C. (2018) Comment on: Successful use of nitrous oxide during lumbar punctures: a call for nitrous oxide in pediatric oncology clinics. Pediatric Blood and Cancer, 65(5), e26930. (doi: 10.1002/pbc.26930) (PMID:29286566)

De Santo, C. et al. (2018) The arginine metabolome in Acute Lymphoblastic Leukemia can be targeted by the PEG-recombinant Arginase I BCT-100. International Journal of Cancer, 142(7), pp. 1490-1502. (doi: 10.1002/ijc.31170) (PMID:29168171) (PMCID:PMC5849425)

Sinclair, P. B. et al. (2018) Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. Haematologica, 103(4), pp. 634-644. (doi: 10.3324/haematol.2017.172304) (PMID:29449437) (PMCID:PMC5865429)

Bartram, J., Goulden, N., Wright, G., Adams, S., Brooks, T., Edwards, D., Inglott, S., Yousafzai, Y., Hubank, M. and Halsey, C. (2018) High throughput sequencing in acute lymphoblastic leukemia reveals clonal architecture of central nervous system and bone marrow compartments. Haematologica, 103, e113. (doi: 10.3324/haematol.2017.174987) (PMID:29217777)

Cousins, A. et al. (2017) Upregulated cholesterol biosynthesis is a biomarker for isolated central nervous system relapse in acute lymphoblastic leukaemia. Blood, 130(Sup 1), 3992.

Forster, V. J., van Delft, F. W., Baird, S. F., Mair, S., Skinner, R. and Halsey, C. (2017) Reply: Methotrexate neurotoxicity due to drug interactions: an inadequate folinic acid effect. Cancer Chemotherapy and Pharmacology, 79(4), pp. 841-842. (doi: 10.1007/s00280-017-3270-4) (PMID:28289862)

Oruganti, S.R., Torres, D.J., Krebsbach, S., Asperti-Boursin, F., Winters, J., Matlawska-Wasowska, K., Winter, S.S., Halsey, C. and Cannon, J.L. (2017) CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS. Leukemia, 31(1), pp. 255-258. (doi: 10.1038/leu.2016.272) (PMID:27698445)

Forster, V. J., van Delft, F. W., Baird, S. F., Mair, S., Skinner, R. and Halsey, C. (2016) Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients. Cancer Chemotherapy and Pharmacology, 78(5), pp. 1093-1096. (doi: 10.1007/s00280-016-3153-0) (PMID:27659182) (PMCID:PMC5083755)

Schmiegelow, K. et al. (2016) Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus. Lancet Oncology, 17(6), e231-e239. (doi: 10.1016/S1470-2045(16)30035-3)

Williams, M. T.S. et al. (2016) The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukaemia blasts. Blood, 127, 16. (doi: 10.1182/blood-2015-08-665034) (PMID:26869395)

Olivares, O., Däbritz, J. H. M., King, A., Gottlieb, E. and Halsey, C. (2015) Research into cancer metabolomics: towards a clinical metamorphosis. Seminars in Cell and Developmental Biology, 43, pp. 52-64. (doi: 10.1016/j.semcdb.2015.09.008) (PMID:26365277)

Irving, J. et al. (2014) Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition. Blood, 124(23), pp. 3420-3430. (doi: 10.1182/blood-2014-04-531871) (PMID:25253770) (PMCID:PMC4246039)

Winter, S. and Halsey, C. (2014) Should children presenting with iron deficiency anaemia be screened for coeliac disease? Archives of Disease in Childhood, 99(2), pp. 180-182. (doi: 10.1136/archdischild-2013-305591)

El-Fakhri, N., McDevitt, H., Shaikh, M.G., Halsey, C. and Ahmed, S.F. (2014) Vitamin D and its effects on glucose homeostasis, cardiovascular function and immune function. Hormone Research in Paediatrics, 81(6), pp. 363-378. (doi: 10.1159/000357731)

Williams, M. T.S. et al. (2014) Interleukin-15 enhances cellular proliferation and up-regulates CNS homing molecules in pre-B acute lymphoblastic leukemia. Blood, 123(20), pp. 3116-3127. (doi: 10.1182/blood-2013-05-499970) (PMID:24700781)

Roberts, I. et al. (2013) GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia. Blood, 122(24), pp. 3908-3917. (doi: 10.1182/blood-2013-07-515148)

Halsey, C. , Docherty, M., McNeill, M., Gilchrist, D., Le Brocq, M., Gibson, B. and Graham, G. (2012) The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells. Journal of Hematology and Oncology, 5, p. 45. (doi: 10.1186/1756-8722-5-45)

Halsey, C. , Buck, G., Richards, S., Vargha-Khadem, F., Hill, F. and Gibson, B. (2011) The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI. Journal of Hematology and Oncology, 4(42), (doi: 10.1186/1756-8722-4-42)

Halsey, C. , Lumley, H. and Luckit, J. (2010) Necrotising external otitis caused by Aspergillus wentii: a case report. Mycoses, 54(4), E211-E213. (doi: 10.1111/J.1439-0507.2009.01815.x)

Halsey, C. , Tunstall, O., Gibson, B., Roberts, I. and Graham, G. (2010) Role of GATA-1s in early hematopoiesis and differences between alternative splicing in human and murine GATA-1. Blood, 115(16), pp. 3415-3416. (doi: 10.1182/blood-2010-02-267930)

McKimmie, C. S. et al. (2008) Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. Journal of Immunology, 181(5), pp. 3353-3363. (doi: 10.4049/jimmunol.181.11.8170-a) (PMID:19039854)

Halsey, C. , Fisher, C., Strathdee, G., Gibson, B., Holyoake, T., Vyas, P. and Graham, G. (2007) GATA1 mutational analysis in chronic myeloid leukaemia. British Journal of Haematology, 137(4), pp. 375-376. (doi: 10.1111/j.1365-2141.2007.06563.x) (PMID:17408401)

Jiskoot, P.M.C., Halsey, C. , Rivers, R., Bain, B.J. and Wilkins, B.S. (2004) Unusual splenic sinusoidal iron overload in sickle cell/haemoglobin D-Punjab disease. Journal of Clinical Pathology, 57(5), pp. 539-540. (doi: 10.1136/jcp.2002.004481) (PMID:15113864) (PMCID:PMC1770290)

Ronghe, M. D., Halsey, C. and Goulden, N. J. (2003) Anticoagulation therapy in children. Pediatric Drugs, 5(12), pp. 803-820. (doi: 10.2165/00148581-200305120-00004) (PMID:14658922)

Amrolia, P. J., Almeida, A., Halsey, C. , Roberts, I. A. G. and Davies, S. C. (2003) Therapeutic challenges in childhood sickle cell disease part 1: current and future treatment options. British Journal of Haematology, 120(5), pp. 725-736. (doi: 10.1046/j.1365-2141.2003.04143.x) (PMID:12614202)

Halsey, C. and Roberts, I. A.G. (2003) The role of hydroxyurea in sickle cell disease. British Journal of Haematology, 120(2), pp. 177-186. (doi: 10.1046/j.1365-2141.2003.03849.x) (PMID:12542474)

Book Sections

Halsey, C. (2014) Haematological investigations in paediatrics. In: Goal, K.M. and Carachi, R. (eds.) Hutchison's Atlas of Paediatric Physical Diagnosis. Jaypee Brothers Medical Publishers: New Delhi. ISBN 9789351521525

Halsey, C. (2014) Towards personalised medicine in childhood acute lymphoblastic leukaemia. In: Thomas, A.E. and Halsey, C. (eds.) Controversies in Pediatric and Adolescent Hematology. Kerger, pp. 98-115. ISBN 9783318024234 (doi: 10.1159/000350349)

Halsey, C. and Chalmers, E.A. (2009) Haematalogical investigations in children. In: Goel, K. and Gupta, D. (eds.) Hutchison's Paediatrics. Jaypee Brothers, Medical Publishers (P) Ltd.. ISBN 9788184485868

Halsey, C.,. and Chalmers, E.A. (2008) Haematological investigations in paediatrics. In: Goel, K.M. and Gupta, D.K. (eds.) Hutchison's Paediatrics. Jaypee Brothers Medical Publishers: New Delhi. ISBN 9788184485868

Halsey, C. and Roberts, I. (2008) Neonatal Haematology. In: Forfar, J.O. and McIntosh, N. (eds.) Forfar and Arneil's Textbook of Pediatrics. Churchill Livingstone: Edinburgh. ISBN 9780443103971

Gibson, B. E.S. and Halsey, C. (2006) Nonimmune neonatal anemias. In: Arceci, R., Hann, I. M. and Smith, O. P. (eds.) Pediatric Hematology. Blackwell Publishing: Malden, pp. 130-150. ISBN 9781405134002 (doi: 10.1002/9780470987001.ch7)

Halsey, C. and Roberts, I. (2003) haemopoietic stem cell transplantation for thalassaemia and sickle cell disease. In: Okpala, I.E. (ed.) Comprehensive Care of Sickle Cell Disease. UNSPECIFIED.

Halsey, C. and Roberts, I. (2003) Neonatal Haematology. In: Forfar, J.O., Arneil, G.C., McIntosh, N., Helms, P. and Smyth, R.L. (eds.) Forfar and Arneil's Textbook of Pediatrics. Churchill Livingstone: Edinburgh. ISBN 9780443071980

Edited Books

Thomas, A.E. and Halsey, C. (2014) Controversies in Pediatric and Adolescent Hematology. Series: Pediatric and Adolescent Medicine. Karger. ISBN 9783318024227

Research Reports or Papers

Welisch, G. et al. (2021) First in Human: who and what makes a cancer phase 1 trial and why are they so important? Project Report. OSF. (doi: 10.17605/OSF.IO/KWHQF).

Conference or Workshop Item

Cousins, A. F., Olivares, O., Michie, A. M. , Gottlieb, E. and Halsey, C. (2017) Association of CNS Involvement in Childhood Acute Lymphoblastic Leukaemia with Cholesterol Biosynthesis Upregulation. Spring Meeting for Clinician Scientists in Training 2017, London, UK, 23 Feb 2017. S35. (doi: 10.1016/S0140-6736(17)30431-2)

Yasar, M. Y. et al. (2013) 3866 An Analysis of Mechanisms of Central Nervous System Infiltration in Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice. 55th ASH Annual Meeting and Exposition, New Orleans, LA, USA, 7-10 Dec 2013.

Conference Proceedings

Williams, M.T., Graham, G. , Gibson, B. and Halsey, C. (2011) Homing to the central nervous system is associated with differential expression of selectins, integrins and chemokine receptors in pre-B acute lymphoblastic leukaemia cell lines. In: 51st Annual Scientific Meeting of the British Society for Haematology, Brighton, UK, 4-6 April 2011, pp. 1-88. (doi: 10.1111/j.1365-2141.2011.08609.x)

Williams, M.T., Graham, G. , Gibson, B. and Halsey, C. (2011) An investigation into the role of interleukin-15 on the growth and survival of pre-B acute lymphoblastic leukaemia cell lines. In: 51st Annual Scientific Meeting of the British Society for Haematology, Brighton, UK, 4-6 April 2011, pp. 1-88. (doi: 10.1111/j.1365-2141.2011.08609.x)