Professor Paul Shiels

Professor of Geroscience (Molecular Biosciences)
Affiliate (School of Cancer Sciences)

telephone: 01413307280
email: Paul.Shiels@glasgow.ac.uk

Institute of Cancer Sciences, Wolfson Wohl Building, Garscube Estate, Bearsden, Glasgow, G61 1QH

Research interests

Dr Shiels career has spanned both industry and academia and has involved 25 years developing a fundamental understanding of biological ageing. He was among the first internationally to clone and analyse telomeres and developed one of the first rat genomic mapping panels to enable the positional cloning of the AGU gene in a bio-ageing mutant (Craig NJ, Duran Alonso MB, Hawker KL, Shiels P, et al (2001) Nat Neuroscience.4:1061-1062). Subsequently, at PPL Therapeutics, Roslin, he helped develop the internationally recognised Xenotransplantation programme and undertook the analysis of senescence in cloned animals (including Dolly the sheep - Shiels PG et al Nature 399:316-317).

Publications

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Number of items: 182.

2024

Minnis, H. et al. (2024) The bio-exposome: intracellular processes, stress physiology and the environment. Nature Mental Health, 2(2), pp. 132-140. (doi: 10.1038/s44220-023-00180-3)

Mafra, D., Ugochukwu, S. A., Borges, N. A., Cardozo, L. F. M. F., Stenvinkel, P. and Shiels, P. G. (2024) Food for healthier aging: power on your plate. Critical Reviews in Food Science and Nutrition, 64(3), pp. 603-616. (doi: 10.1080/10408398.2022.2107611) (PMID:35959705)

2023

Neytchev, O. et al. (2023) Epigenetic clocks indicate that kidney transplantation and not dialysis mitigate the effects of renal ageing. Journal of Internal Medicine, 295(1), pp. 79-90. (doi: 10.1111/joim.13724)

Craven, H., Erlandsson, H., McGuinness, D., McGuinness, D. , Mafra, D., Ijaz, U. Z. , Bergman, P., Shiels, P. G. and Stenvinkel, P. (2023) A normative microbiome is not restored following kidney transplantation. Clinical Science, 137(20), pp. 1563-1575. (doi: 10.1042/CS20230779) (PMID:37756543)

Shiels, P. G. (2023) ‘Debugging’ heart failure. Journal of Internal Medicine, 294(4), pp. 374-376. (doi: 10.1111/joim.13691) (PMID:37424184)

Zhou, Z. , Lo, C. K.M., Chan, K. L., Chung, R. S.Y., Pell, J. P. , Minnis, H. , Shiels, P. G. , Ip, P. and Ho, F. K. (2023) Child maltreatment and telomere length in middle and older age: retrospective cohort study of 141 748 UK Biobank participants. British Journal of Psychiatry, 223(2), pp. 377-381. (doi: 10.1192/bjp.2023.33) (PMID:36946056)

Panagiotou, N. , McGuinness, D., Jaminon, A. M.G., Mees, B., Selman, C. , Schurgers, L. and Shiels, P. G. (2023) Microvesicle-mediated tissue regeneration mitigates the effects of cellular ageing. Cells, 12(13), 1707. (doi: 10.3390/cells12131707) (PMID:37443741) (PMCID:PMC10340655)

Kalogeropoulu, S. K., Rauch-Schmücking, H., Lloyd, E. J., Stenvinkel, P., Shiels, P. G. , Johnson, R. J., Fröbert, O., Redtenbacher, I., Burgener, I. A. and Painer-Gigler, J. (2023) Formerly bile-farmed bears as a model of accelerated ageing. Scientific Reports, 13, 9691. (doi: 10.1038/s41598-023-36447-z) (PMID:37322151) (PMCID:PMC10272202)

Baptista, B. G., Fanton, S., Ribeiro, M., Cardozo, L. F.M.F., Regis, B., Alvarenga, L., Ribeiro-Alves, M., Berretta, A. A., Shiels, P. G. and Mafra, D. (2023) The effect of Brazilian green propolis extract on inflammation in patients with chronic kidney disease on peritoneal dialysis: a randomised double-blind controlled clinical trial. Phytomedicine, 114, 154731. (doi: 10.1016/j.phymed.2023.154731) (PMID:36934668)

Dai, L., Mafra, D. , Shiels, P. G. , Hackeng, T. M., Stenvinkel, P. and Schurgers, L. J. (2023) Vitamin K and hallmarks of ageing: focus on diet and gut microbiome. Nutrients, 15(12), 2727. (doi: 10.3390/nu15122727) (PMID:37375631) (PMCID:PMC10301624)

Hill, C. et al. (2023) Differential methylation of telomere-related genes is associated with kidney disease in individuals with type 1 diabetes. Genes, 14(5), 1029. (doi: 10.3390/genes14051029) (PMID:37239390) (PMCID:PMC10217816)

Shiels, P. , Tran, N. , McCavitt, J., Neytchev, O. and Stenvinkel, P. (2023) Chronic kidney disease and the exposome of ageing. In: Harris, J.R. and Korolchuk, V.I. (eds.) Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science. Series: Subcellular biochemistry (103). Springer: Cham, pp. 79-94. ISBN 9783031265754 (doi: 10.1007/978-3-031-26576-1_5)

Hobson, S., Arefin, S., Witasp, A., Hernandez, L., Kublickiene, K., Shiels, P.G. and Stenvinkel, P. (2023) Accelerated vascular aging in chronic kidney disease: the potential for novel therapies. Circulation Research, 132(8), pp. 950-969. (doi: 10.1161/CIRCRESAHA.122.321751) (PMID:37053277)

Moreira, L. d. S. G., Brum, I. d. S. d. C., de Vargas Reis, D. C.M., Trugilho, L., Chermut, T. R., Esgalhado, M., Cardozo, L. F.M.F., Stenvinkel, P., Shiels, P. G. and Mafra, D. (2023) Cinnamon: an aromatic condiment applicable to chronic kidney disease. Kidney Research and Clinical Practice, 42(1), pp. 4-26. (doi: 10.23876/j.krcp.22.111) (PMID:36747357) (PMCID:PMC9902738)

Chan, K. L., Lo, C. K.M., Chen, X.-Y., Ip, P., Leung, W. C., Shiels, P. G. , Pell, J. P. , Minnis, H. and Ho, F. K. (2023) Association between intimate partner violence and leukocyte telomere length: a retrospective cohort study of 144,049 UK Biobank participants. Epidemiology and Psychiatric Sciences, 32, e26. (doi: 10.1017/S2045796023000112) (PMCID:PMC10130734)

Mafra, D., Borges, N. A., Alvarenga, L., Ribeiro, M., Fonseca, L., Leal, V. O., Shiels, P. G. and Stenvinkel, P. (2023) Fermented food: should patients with cardiometabolic diseases go back to an early neolithic diet? Critical Reviews in Food Science and Nutrition, 63(29), pp. 10173-10196. (doi: 10.1080/10408398.2022.2077300) (PMID:35593230)

2022

Mafra, D. et al. (2022) Archaea from the gut microbiota of humans: Could be linked to chronic diseases? Anaerobe, 77, 102629. (doi: 10.1016/j.anaerobe.2022.102629) (PMID:35985606)

Ebert, T., Tran, N. , Schurgers, L., Stenvinkel, P. and Shiels, P. G. (2022) Ageing – oxidative stress, PTMs and disease. Molecular Aspects of Medicine, 86, 101099. (doi: 10.1016/j.mam.2022.101099) (PMID:35689974)

Mafra, D., Cardozo, L., Ribeiro-Alves, M., Bergman, P., Shiels, P. G. and Stenvinkel, P. (2022) Short Report: Choline plasma levels are related to Nrf2 transcriptional expression in chronic kidney disease? Clinical Nutrition ESPEN, 50, pp. 318-321. (doi: 10.1016/j.clnesp.2022.06.008) (PMID:35871941)

de Souza Gouveia Moreira, L., Fanton, S., Cardozo, L., Borges, N. A., Combet, E. , Shiels, P. G. , Stenvinkel, P. and Mafra, D. (2022) Pink pressure: beetroot (Beta vulgaris rubra) as a possible novel medical therapy for chronic kidney disease. Nutrition Reviews, 80(5), pp. 1041-1061. (doi: 10.1093/nutrit/nuab074) (PMID:34613396)

Witasp, A., Luttropp, K., Qureshi, A. R., Barany, P., Heimbürger, O., Wennberg, L., Ekström, T. J., Shiels, P. G. , Stenvinkel, P. and Nordfors, L. (2022) Longitudinal genome-wide DNA methylation changes in response to kidney failure replacement therapy. Scientific Reports, 12, 470. (doi: 10.1038/s41598-021-04321-5) (PMID:35013499) (PMCID:PMC8748627)

2021

Cardozo, L. F.M.F., Alvarenga, L. A., Ribeiro, M., Dai, L., Shiels, P. G. , Stenvinkel, P., Lindholm, B. and Mafra, D. (2021) Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease. Nutrition Reviews, 79(11), pp. 1204-1224. (doi: 10.1093/nutrit/nuaa129) (PMID:33338213)

Kemp, J. A., Paiva, B. R., dos Santos, H. F., Jesus, H. E., Craven, H., Ijaz, U. Z. , Borges, N. A., Shiels, P. G. and Mafra, D. (2021) The impact of enriched resistant starch type‐2 cookies on the gut microbiome in hemodialysis patients: a randomized controlled trial. Molecular Nutrition and Food Research, 65(19), 2100374. (doi: 10.1002/mnfr.202100374) (PMID:34390604)

Craven, H. et al. (2021) Socioeconomic position links circulatory microbiota differences with biological age. Scientific Reports, 11, 12629. (doi: 10.1038/s41598-021-92042-0) (PMID:34135381) (PMCID:PMC8209159)

Ebert, T., Neytchev, O. , Witasp, A., Kublickiene, K., Stenvinkel, P. and Shiels, P. (2021) Inflammation and oxidative stress in CKD and dialysis patients. Antioxidants and Redox Signaling, 35(17), pp. 1426-1448. (doi: 10.1089/ars.2020.8184) (PMID:34006115)

Dai, L., Schurgers, L., Shiels, P. G. and Stenvinkel, P. (2021) A biomimetic natural sciences approach to understanding the mechanisms of ageing in burden of life style diseases. Clinical Science, 135(10), pp. 1251-1272. (doi: 10.1042/CS20201452) (PMID:34037207)

Kooman, J. P., Stenvinkel, P., Shiels, P. G. , Feelisch, M., Canaud, B. and Kotanko, P. (2021) The oxygen cascade in hemodialysis patients and native high altitude dwellers- lessons from extreme physiology to benefit patients with end-stage renal disease. American Journal of Physiology: Renal Physiology, 320(3), F249-F261. (doi: 10.1152/ajprenal.00540.2020) (PMID:33356957)

Stenvinkel, P., Painer, J., Shiels, P.G. , Bansal, A., Fereidouni, S., Natterson-Horowitz, B., Johnson, R.J. and Miranda, J.J. (2021) SARS-COV-2 and biomimetics: what saves the planet will save our health. Journal of Internal Medicine, 289(2), pp. 244-246. (doi: 10.1111/joim.13128) (PMID:32583447) (PMCID:PMC7361468)

Fanton, S., Cardozo, L. F.M.F., Combet, E. , Shiels, P. G. , Stenvinkel, P., Vieira, I. O., Narciso, H. R., Schmitz, J. and Mafra, D. (2021) The sweet side of dark chocolate for chronic kidney disease patients. Clinical Nutrition, 40(1), pp. 15-26. (doi: 10.1016/j.clnu.2020.06.039) (PMID:32718711)

Mafra, D., Borges, N. A., Lindholm, B., Shiels, P. G. , Evenepoel, P. and Stenvinkel, P. (2021) Food as medicine: targeting the uraemic phenotype in chronic kidney disease. Nature Reviews Nephrology, 17, pp. 153-171. (doi: 10.1038/s41581-020-00345-8) (PMID:32963366)

2020

Ebert, T. et al. (2020) Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears. Scientific Reports, 10, 20323. (doi: 10.1038/s41598-020-76346-1) (PMID:33230252) (PMCID:PMC7684304)

Markopoulou, P., Panagiotou, N. , Li, A., Bueno-Perez, R., Madden, D., Buchanan, S., Fairen-Jimenez, D., Shiels, P. G. and Forgan, R. S. (2020) Identifying differing intracellular cargo release mechanisms by monitoring in vitro drug delivery from MOFs in real time. Cell Reports Physical Science, 1, 100254. (doi: 10.1016/j.xcrp.2020.100254)

Alvarenga, L., Cardozo, L. F.M.F., Borges, N., Bengt, L., Stenvinkel, P., Shiels, P. G. , Fouque, D. and Mafra, D. (2020) Can nutritional interventions modulate the activation of the NLRP3 inflammasome in chronic kidney disease? Food Research International, 136, 109306. (doi: 10.1016/j.foodres.2020.109306) (PMID:32846516)

Buchanan, S., Combet, E. , Stenvinkel, P. and Shiels, P.G. (2020) Klotho, ageing and the failing kidney. Frontiers in Endocrinology, 11, 560. (doi: 10.3389/fendo.2020.00560) (PMID:32982966) (PMCID:PMC7481361)

Stenvinkel, P., Shiels, P. G. , Painer, J., Miranda, J. J., Natterson-Horowitz, B. and Johnson, R. J. (2020) A planetary health perspective for kidney disease. Kidney International, 98(2), pp. 261-265. (doi: 10.1016/j.kint.2020.03.024) (PMID:32709283) (PMCID:PMC7372277)

Arefin, S., Buchanan, S., Hobson, S., Steinmetz, J., Alsalhi, S., Shiels, P. G. , Kublickiene, K. and Stenvinkel, P. (2020) Nrf2 in early vascular ageing: calcification, senescence and therapy. Clinica Chimica Acta, 505, pp. 108-118. (doi: 10.1016/j.cca.2020.02.026) (PMID:32097628)

Ebert, T., Pawelzik, S.-C., Witasp, A., Arefin, S., Hobson, S., Kublickiene, K., Shiels, P. G. , Bäck, M. and Stenvinkel, P. (2020) Inflammation and premature ageing in chronic kidney disease. Toxins, 12(4), 227. (doi: 10.3390/toxins12040227) (PMID:32260373) (PMCID:PMC7232447)

O'Toole, P.W. and Shiels, P. G. (2020) The role of the microbiota in sedentary life style disorders and ageing: lessons from the animal kingdom. Journal of Internal Medicine, 287(3), pp. 271-282. (doi: 10.1111/joim.13021) (PMID:31957113)

Kooman, J. P., Stenvinkel, P. and Shiels, P. G. (2020) Fabry disease: a new model of premature aging? Nephron, 144(1), pp. 1-4. (doi: 10.1159/000503290) (PMID:31563917) (PMCID:PMC6979416)

2019

de Kok, M. J. et al. (2019) The neglectable impact of delayed graft function on long-term graft survival in kidneys donated after circulatory death associates with superior organ resilience. Annals of Surgery, 270(5), pp. 877-883. (doi: 10.1097/SLA.0000000000003515) (PMID:31567503)

Shiels, P. G. , Buchanan, S., Selman, C. and Stenvinkel, P. (2019) Allostatic load and ageing; linking the microbiome and nutrition with age related health. Biochemical Society Transactions, 47(4), pp. 1165-1172. (doi: 10.1042/BST20190110) (PMID:31416886)

Stenvinkel, P. and Shiels, P. G. (2019) Long-lived animals with negligible senescence: clues for ageing research. Biochemical Society Transactions, 47(4), pp. 1157-1164. (doi: 10.1042/BST20190105) (PMID:31366472)

Lang, J., McKie, J., Smith, H., McLaughlin, A., Gillberg, C. , Shiels, P. G. and Minnis, H. (2019) Adverse childhood experiences, epigenetics and telomere length variation in childhood and beyond: a systematic review of the literature. European Child and Adolescent Psychiatry, (doi: 10.1007/s00787-019-01329-1) (PMID:30968208) (PMCID:PMC7501093)

Ellaway, A. , Dundas, R. , Robertson, T. and Shiels, P. G. (2019) More miles on the clock: neighbourhood stressors are associated with telomere length in a longitudinal study. PLoS ONE, 14(3), e0214380. (doi: 10.1371/journal.pone.0214380) (PMID:30921393) (PMCID:PMC6438484)

Acosta-Herrera, M. et al. (2019) Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. Annals of the Rheumatic Diseases, 78(3), pp. 311-319. (doi: 10.1136/annrheumdis-2018-214127) (PMID:30573655) (PMCID:PMC6800208)

Ledeganck, K. J., Gielis, E. M., Abramowicz, D., Stenvinkel, P., Shiels, P. G. and Van Craenenbroeck, A. H. (2019) MicroRNAs in AKI and kidney transplantation. Clinical Journal of the American Society of Nephrology, 14(3), pp. 454-468. (doi: 10.2215/CJN.08020718) (PMID:30602462) (PMCID:PMC6419285)

Mafra, D., Esgalhado, M., Borges, N. A., Cardozo, L. F.M.F., Stockler-Pinto, M. B., Craven, H., Buchanan, S. J., Lindholm, B., Stenvinkel, P. and Shiels, P. G. (2019) Methyl donor nutrients in chronic kidney disease: impact on the epigenetic landscape. Journal of Nutrition, 149(3), pp. 372-380. (doi: 10.1093/jn/nxy289) (PMID:30796783)

Hobson, S., Arefin, S., Kublickiene, K., Shiels, P. G. and Stenvinkel, P. (2019) Senescent cells in early vascular ageing and bone disease of chronic kidney disease—a novel target for treatment. Toxins, 11(2), 82. (doi: 10.3390/toxins11020082) (PMID:30717151) (PMCID:PMC6409791)

2018

Stevenson, R., Shapter, O., Aitken, E., Stevenson, K., Shiels, P.G. and Kingsmore, D.B. (2018) Has the expansion in extended criteria deceased donors led to a different type of delayed graft function and poorer outcomes? Transplantation Proceedings, 50(10), pp. 3160-3164. (doi: 10.1016/j.transproceed.2018.07.022) (PMID:30577182)

McGuinness, D. et al. (2018) A molecular signature for delayed graft function. Aging Cell, 17(5), e12825. (doi: 10.1111/acel.12825) (PMID:30094915) (PMCID:PMC6156499)

Ellaway, A. , Dundas, R. , Olsen, J. R. and Shiels, P. G. (2018) Perceived neighbourhood problems over time and associations with adiposity. International Journal of Environmental Research and Public Health, 15(9), 1854. (doi: 10.3390/ijerph15091854) (PMID:30154306) (PMCID:PMC6164418)

Panagiotou, N. , Neytchev, O. , Selman, C. and Shiels, P. G. (2018) Extracellular vesicles, ageing, and therapeutic interventions. Cells, 7(8), 110. (doi: 10.3390/cells7080110) (PMID:30126173) (PMCID:PMC6115766)

Maguire, D., Talwar, D., Shiels, P. G. and McMillan, D. (2018) The role of thiamine dependent enzymes in obesity and obesity related chronic disease states: a systematic review. Clinical Nutrition ESPEN, 25, pp. 8-17. (doi: 10.1016/j.clnesp.2018.02.007) (PMID:29779823)

Maguire, D., Neytchev, O. , Talwar, D., McMillan, D. and Shiels, P. (2018) Telomere homeostasis: interplay with magnesium. International Journal of Molecular Sciences, 19(1), 157. (doi: 10.3390/ijms19010157) (PMID:29303978) (PMCID:PMC5796106)

Lakhdar, R., McGuinness, D., Drost, E. M., Shiels, P. G. , Bastos, R., MacNee, W. and Rabinovich, R. A. (2018) Role of accelerated ageing in limb muscle wasting of patients with COPD. International Journal of Chronic Obstructive Pulmonary Disease, 13, pp. 1987-1998. (doi: 10.2147/COPD.S155952) (PMID:29970961) (PMCID:PMC6022820)

Stenvinkel, P., Painer, J., Kuro-o, M., Lanaspa, M., Arnold, W., Ruf, T., Shiels, P. G. and Johnson, R. J. (2018) Novel treatment strategies for chronic kidney disease: insights from the animal kingdom. Nature Reviews Nephrology, 14, pp. 265-284. (doi: 10.1038/nrneph.2017.169) (PMID:29332935)

2017

Lu, L., Johnman, C., McGlynn, L., Mackay, D. F. , Shiels, P. G. and Pell, J. P. (2017) Association between exposure to second-hand smoke and telomere length: cross-sectional study of 1303 non-smokers. International Journal of Epidemiology, 46(6), pp. 1978-1984. (doi: 10.1093/ije/dyx212) (PMID:29040594)

Bossini-Castillo, L. et al. (2017) An MIF promoter polymorphism is associated with susceptibility to pulmonary arterial hypertension in diffuse cutaneous systemic sclerosis. Journal of Rheumatology, 44(10), pp. 1453-1457. (doi: 10.3899/jrheum.161369) (PMID:28668810)

Kooman, J. P., Dekker, M. J., Usvyat, L. A., Kotanko, P., van der Sande, F. M., Schalkwijk, C. G., Shiels, P. G. and Stenvinkel, P. (2017) Inflammation and premature aging in advanced chronic kidney disease. American Journal of Physiology: Renal Physiology, 313(4), F938-F950. (doi: 10.1152/ajprenal.00256.2017) (PMID:28701312)

Shiels, P. G. , McGuinness, D., Eriksson, M., Kooman, J. P. and Stenvinkel, P. (2017) The role of epigenetics in renal ageing. Nature Reviews Nephrology, 13, pp. 471-482. (doi: 10.1038/nrneph.2017.78) (PMID:28626222)

Witasp, A., Van Craenenbroeck, A. H., Shiels, P. G. , Ekström, T. J., Stenvinkel, P. and Nordfors, L. (2017) Current epigenetic aspects the clinical kidney researcher should embrace. Clinical Science, 131(14), pp. 1649-1667. (doi: 10.1042/CS20160596) (PMID:28667065)

Vazirpanah, N. et al. (2017) Patients with gout have short telomeres compared with healthy participants: association of telomere length with flare frequency and cardiovascular disease in gout. Annals of the Rheumatic Diseases, 76(7), pp. 1309-1315. (doi: 10.1136/annrheumdis-2016-210538) (PMID:28347991)

Shiels, P. G. , Stenvinkel, P., Kooman, J. P. and McGuinness, D. (2017) Circulating markers of ageing and allostatic load: a slow train coming. Practical Laboratory Medicine, 7, pp. 49-54. (doi: 10.1016/j.plabm.2016.04.002) (PMID:28856219) (PMCID:PMC5574864)

Stenvinkel, P. et al. (2017) CDKN2A/p16INK4a expression is associated with vascular progeria in chronic kidney disease. Aging, 9(2), pp. 494-507. (doi: 10.18632/aging.101173) (PMID:28192277)

2016

Luttropp, K. et al. (2016) Increased telomere attrition following renal transplantation: impact of anti-metabolite therapy. Transplantation Direct, 2(12), e116. (doi: 10.1097/TXD.0000000000000629) (PMID:27990481) (PMCID:PMC5142370)

Panagiotou, N. , Davies, R. W., Selman, C. and Shiels, P. G. (2016) Microvesicles as vehicles for tissue regeneration: Changing of the guards. Current Pathobiology Reports, 4(4), pp. 181-187. (doi: 10.1007/s40139-016-0115-5) (PMID:27882267) (PMCID:PMC5101251)

McGuinness, D., Anthony, D. F., Moulisova, V. , MacDonald, A. I., Macintyre, A., Thomson, J., Nag, A., Davies, R. W. and Shiels, P. G. (2016) Microvesicles but not exosomes from Pathfinder Cells stimulate functional recovery of the pancreas in a mouse streptozotocin-induced diabetes model. Rejuvenation Research, 19(3), pp. 223-232. (doi: 10.1089/rej.2015.1723)

McClelland, R. et al. (2016) Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake. Aging, 8(5), pp. 1135-1149. (doi: 10.18632/aging.100948) (PMID:27132985) (PMCID:PMC4931858)

Bulteel, N., McGuinness, D., Shiels, P. G. and McLauchlan, J. (2016) Circulating micrornas as biomarkers for disease progression in chronic hepatitis C virus infection. EASL International Liver Congress 2016, Barcelona, Spain, 13-17 Apr 2016.

Whalen, H., Shiels, P. , Littlejohn, M. and Clancy, M. (2016) A novel rodent model of severe renal ischemia reperfusion injury. Renal Failure, 38(10), pp. 1694-1701. (doi: 10.3109/0886022x.2016.1144024) (PMID:26887330)

McGuinness, D. et al. (2016) Identification of molecular markers of delayed graft function based on the regulation of biological ageing. PLoS ONE, 11(1), e0146378. (doi: 10.1371/journal.pone.0146378) (PMID:26734715) (PMCID:PMC4703336)

Stenvinkel, P., Kooman, J. P. and Shiels, P. G. (2016) Nutrients and ageing: what can we learn about ageing interactions from animal biology? Current Opinion in Clinical Nutrition and Metabolic Care, 19(1), pp. 19-25. (doi: 10.1097/MCO.0000000000000234) (PMID:26485336)

Kato, S., Shiels, P. G. , McGuinness, D., Lindholm, B., Stenvinkel, P., Nordfors, L., Qureshi, A. R., Yuzawa, Y., Matsuo, S. and Maruyama, S. (2016) Telomere attrition and elongation after dialysis therapy initiation in patients with end-stage renal disease. Blood Purification, 41(1-3), pp. 25-33. (doi: 10.1159/000440971)

Khojah, S. M., McGuinness, D., Shiels, P. G. and Payne, A. (2016) Differential Pattern of Global DNA Methylation at Two Time Points in Brain Regions of AS/AGU Rats Compared with AS Rats. In: Eighth Saudi Students Conference in the UK, London, UK, 31 Jan - 01 Feb 2015, pp. 625-631. ISBN 9781783269143 (doi: 10.1142/9781783269150_0051)

2015

Curley, H., McGuinness, D., Kinsella, J., Quasim, T. and Shiels, P. (2015) Intensive care unit outcomes based on telomere length as a biomarker of ageing: a pilot study. British Journal of Anaesthesia, 115(6(e)), pp. 950-962. (doi: 10.1093/bja/aev116)

Kooman, J. P., Shiels, P. G. and Stenvinkel, P. (2015) Premature aging in chronic kidney disease and chronic obstructive pulmonary disease. Current Opinion in Clinical Nutrition and Metabolic Care, 18(6), pp. 528-534. (doi: 10.1097/mco.0000000000000218) (PMID:26372510)

Martin-Ruiz, C. M. et al. (2015) Is Southern blotting necessary to measure telomere length reproducibly? Authors’ Response to: Commentary: The reliability of telomere length measurements. International Journal of Epidemiology, 44(5), pp. 1686-1687. (doi: 10.1093/ije/dyv169) (PMID:26403813)

McGlynn, L. M., McCluney, S., Jamieson, N. B. , Thomson, J., MacDonald, A. I., Oien, K. , Dickson, E. J., Carter, C. R., McKay, C. J. and Shiels, P. G. (2015) SIRT3 & SIRT7: potential novel biomarkers for determining outcome in pancreatic cancer patients. PLoS ONE, 10(6), e0131344. (doi: 10.1371/journal.pone.0131344) (PMID:26121130) (PMCID:PMC4487247)

Martin-Ruiz, C. M. et al. (2015) Reproducibility of telomere length assessment: Authors’ Response to Damjan Krstajic and Ljubomir Buturovic. International Journal of Epidemiology, 44(5), pp. 1739-1741. (doi: 10.1093/ije/dyv170) (PMID:26403811)

Ochoa, E. et al. (2015) Confirmation of CCR6 as a risk factor for anti-topoisomerase I antibodies in systemic sclerosis. Clinical and Experimental Rheumatology, 33(4Sup91), S31-S35. (PMID:26314374)

Shiels, P. and Ritzau-Reid, K. (2015) Biological ageing, inflammation and nutrition: how might they impact on systemic sclerosis? Current Aging Science, 8(2), pp. 123-130. (doi: 10.2174/187460980801150727110353) (PMID:26212058)

2014

Kooman, J. P., Kotanko, P., Schols, A. M. W. J., Shiels, P. G. and Stenvinkel, P. (2014) Chronic kidney disease and premature ageing. Nature Reviews Nephrology, 10(12), pp. 732-742. (doi: 10.1038/nrneph.2014.185)

Lu, L., Johnman, C., McGlynn, L., Mackay, D.F. , Shiels, P. and Pell, J.P. (2014) Association between telomere length, inflammation and cardiovascular risk. European Journal of Public Health, 24(S2), p. 273. (doi: 10.1093/eurpub/cku165.080)

Martin-Ruiz, C. M. et al. (2014) Reproducibility of telomere length assessment: an international collaborative study. International Journal of Epidemiology, 44(5), pp. 1673-1683. (doi: 10.1093/ije/dyu191) (PMID:25239152) (PMCID:PMC4681105)

Gardner, M. et al. (2014) Gender and telomere length: systematic review and meta-analysis. Experimental Gerontology, 51, pp. 15-27. (doi: 10.1016/j.exger.2013.12.004) (PMID:24365661) (PMCID:PMC4523138)

Mayes, M. D. et al. (2014) Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. American Journal of Human Genetics, 94(1), pp. 47-61. (doi: 10.1016/j.ajhg.2013.12.002) (PMID:24387989) (PMCID:PMC3882906)

McGlynn, L.M. et al. (2014) SIRT2: Tumour suppressor or tumour promoter in operable breast cancer? European Journal of Cancer, 50(2), pp. 290-301. (doi: 10.1016/j.ejca.2013.10.005) (PMID:24183459)

Alfred, T. et al. (2014) Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme. Age, 36(4), 9673. (doi: 10.1007/s11357-014-9673-9) (PMID:25073452) (PMCID:PMC4150901)

López-Isac, E. et al. (2014) A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility. Arthritis Research and Therapy, 16, R6. (doi: 10.1186/ar4432) (PMID:24401602) (PMCID:PMC3978735)

2013

Cavanagh, J. et al. (2013) Socioeconomic status and the cerebellar grey matter volume. Data from a well-characterised population sample. Cerebellum, 12(6), pp. 882-891. (doi: 10.1007/s12311-013-0497-4)

Carmona, F. D. et al. (2013) New insight on the Xq28 association with systemic sclerosis. Annals of the Rheumatic Diseases, 72(12), pp. 2032-2038. (doi: 10.1136/annrheumdis-2012-202742) (PMID:23444193) (PMCID:PMC3818491)

Robinson, M. W., McGuinness, D., Swann, R. , Barclay, S., Mills, P. R., Patel, A. H. , McLauchlan, J. and Shiels, P. G. (2013) Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease. Aging Cell, 12(6), pp. 1141-1143. (doi: 10.1111/acel.12125) (PMID:23931242)

Krishnadas, R. et al. (2013) Socioeconomic deprivation and cortical morphology: psychological, social, and biological determinants of ill health study. Psychosomatic Medicine, 75(7), pp. 616-623. (doi: 10.1097/PSY.0b013e3182a151a7)

Pathai, S., Shiels, P.G. , Weiss, H.A., Gilbert, C.E., Peto, T., Bekker, L., Wood, R., Wong, T.Y. and Lawn, S.D. (2013) Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing. Mechanisms of Ageing and Development, 134(9), pp. 400-406. (doi: 10.1016/j.mad.2013.08.002)

Pathai, S., Gilbert, C.E., Lawn, S.D., Weiss, H.A., Peto, T., Cook, C., Wong, T.Y. and Shiels, P.G. (2013) Assessment of candidate ocular biomarkers of ageing in a South African adult population: relationship with chronological age and systemic biomarkers. Mechanisms of Ageing and Development, 134(7-8), pp. 338-345. (doi: 10.1016/j.mad.2013.05.002)

Pathai, S., Shiels, P.G. , Lawn, S.D., Cook, C. and Gilbert, C. (2013) The eye as a model of ageing in translational research – molecular, epigenetic and clinical aspects. Ageing Research Reviews, 12(2), pp. 490-508. (doi: 10.1016/j.arr.2012.11.002)

McGlynn, L.M., Eller, K., MacDonald, A.I., MacIntyre, A., Russell, D., Koppelstaetter, C., Davies, R. and Shiels, P.G. (2013) Pathfinder cells provide a novel therapeutic intervention for acute kidney injury. Rejuvenation Research, 16(1), pp. 11-20. (doi: 10.1089/rej.2012.1350)

Gingell-Littlejohn, M., Kohli, H., Aitken, E., Shiels, P.G. , Geddes, C., Kingsmore, D. and Clancy, M.J. (2013) Below-target postoperative arterial blood pressure but not central venous pressure is associated with delayed graft function. Transplantation Proceedings, 45(1), pp. 46-50. (doi: 10.1016/j.transproceed.2012.03.058)

Bossini-Castillo, L. et al. (2013) Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study. Annals of the Rheumatic Diseases, 72(4), pp. 602-607. (doi: 10.1136/annrheumdis-2012-201888)

Carmona, F.D. et al. (2013) The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis. PLoS ONE, 8(1), e54419. (doi: 10.1371/journal.pone.0054419) (PMID:23372721) (PMCID:PMC3553151)

Diaz-Gallo, L.M. et al. (2013) Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility. Annals of the Rheumatic Diseases, 72(7), pp. 1233-1238. (doi: 10.1136/annrheumdis-2012-202357)

Gardner, M.P. et al. (2013) Telomere length and physical performance at older ages: an individual participant meta-analysis. PLoS ONE, 8(7), e69526. (doi: 10.1371/journal.pone.0069526) (PMID:23922731) (PMCID:PMC3724915)

Gingell-Littlejohn, M., McGuinness, D., McGlynn, L.M., Kingsmore, D., Stevenson, K.S., Koppelstaetter, C., Clancy, M.J. and Shiels, P. (2013) Pre-transplant CDKN2A expression in kidney biopsies predicts renal function and is a future component of donor scoring criteria. PLoS ONE, 8(7), e68133. (doi: 10.1371/journal.pone.0068133) (PMID:23861858) (PMCID:PMC3701657)

Krishnadas, R. et al. (2013) Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: results from the psychological, social and biological determinants of ill health (pSoBid) study. NeuroImage: Clinical, 2(2013), pp. 646-657. (doi: 10.1016/j.nicl.2013.04.012)

Millar, K. et al. (2013) Personality, socio-economic status and inflammation: cross-sectional, population-based study. PLoS ONE, 8(3), e58256. (doi: 10.1371/journal.pone.0058256) (PMID:23516457) (PMCID:PMC3596406)

Pathai, S. et al. (2013) Accelerated biological aging in HIV-infected individuals in South Africa: a case–control study. AIDS, 27(15), pp. 2375-2384. (doi: 10.1097/QAD.0b013e328363bf7f)

Pathai, S., Lawn, S.D., Shiels, P.G. , Weiss, H.A., Cook, C., Wood, R. and Gilbert, C.E. (2013) Corneal endothelial cells provide evidence of accelerated cellular senescence associated with HIV infection: a case-control study. PLoS ONE, 8(2), e57422. (doi: 10.1371/journal.pone.0057422) (PMID:23460854) (PMCID:PMC3584030)

Robertson, T., Batty, G.S., Der, G., Fenton, C., Shiels, P.G. and Benzeval, M. (2013) Is socioeconomic status associated with biological aging as measured by telomere length? Epidemiologic Reviews, 35(1), pp. 98-111. (doi: 10.1093/epirev/mxs001)

Roxburgh, C.S. , Richards, C.H., MacDonald, A.I., Powell, A.G., McGlynn, L.M., McMillan, D.C. , Horgan, P.G. , Edwards, J. and Shiels, P.G. (2013) The in situ local immune response, tumour senescence and proliferation in colorectal cancer. British Journal of Cancer, 109(8), pp. 2207-2216. (doi: 10.1038/bjc.2013.556)

2012

Sebastián, C. et al. (2012) The histone deacetylase SIRT6 is a novel tumor suppressor that controls cancer metabolism. Cell, 151(6), pp. 1185-1199. (doi: 10.1016/j.cell.2012.10.047) (PMID:23217706) (PMCID:PMC3526953)

McLean, J. et al. (2012) Early life socioeconomic status, chronic physiological stress and hippocampal N-acetyl aspartate concentrations. Behavioural Brain Research, 235(2), pp. 225-230. (doi: 10.1016/j.bbr.2012.08.013)

Packard, C. et al. (2012) Interaction of personality traits with social deprivation in determining mental wellbeing and health behaviours. Journal of Public Health, 34(4), pp. 615-624. (doi: 10.1093/pubmed/fds030)

Miller, A. M. et al. (2012) Soluble ST2 associates with diabetes but not established cardiovascular risk factors: a new inflammatory pathway of relevance to diabetes? PLoS ONE, 7(10), e47830. (doi: 10.1371/journal.pone.0047830) (PMID:23112853) (PMCID:PMC3480428)

Knox, S. et al. (2012) 25-hydroxyvitamin D is lower in deprived groups, but is not associated with carotid intima media thickness or plaques: results from pSoBid. Atherosclerosis, 223(2), pp. 437-441. (doi: 10.1016/j.atherosclerosis.2012.05.001) (PMID:22632919)

Robertson, T., Batty, G.D., Der, G., Green, M.J., McGlynn, L.M., McIntyre, A., Shiels, P.G. and Benzeval, M. (2012) Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 study. PLoS ONE, 7(7), e41805. (doi: 10.1371/journal.pone.0041805) (PMID:22844525) (PMCID:PMC3402400)

Bossini-Castillo, L. et al. (2012) A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations. Human Molecular Genetics, 21(4), pp. 926-933. (doi: 10.1093/hmg/ddr522)

McGuinness, D. et al. (2012) Socio-economic status is associated with epigenetic differences in the pSoBid cohort. International Journal of Epidemiology, 41(1), pp. 151-160. (doi: 10.1093/ije/dyr215)

Alfred, T. et al. (2012) A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon Programme. PLoS ONE, 7(1), e29883. (doi: 10.1371/journal.pone.0029883) (PMID:22253814) (PMCID:PMC3254646)

Bossini-Castillo, L. et al. (2012) KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor. Arthritis Research and Therapy, 14(6), R273. (doi: 10.1186/ar4124)

Der, G., Batty, G.D., Benzeval, M., Deary, I.J., Green, M.J., McGlynn, L., McIntyre, A., Robertson, T. and Shiels, P.G. (2012) Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland? PLoS ONE, 7(9), e45166. (doi: 10.1371/journal.pone.0045166) (PMID:23028820) (PMCID:PMC3454419)

Gardani, M. , McMillan, T., Shiels, P. , McGlynn, L. and Stewart, E. (2012) An investigation of biological ageing processes following head injury. In: International Brain Injury Association's Ninth World Congress on Brain Injury, Edinburgh, UK, 21-25 Mar 2012, pp. 679-680. (doi: 10.3109/02699052.2012.660091)

Gingell-Littlejohn, M., McGuinness, D., Stevenson, K. S., Kingsmore, D. B., Clancy, M. and Shiels, P. G. (2012) CDKN2A Expression in Pre-Implantation Kidney Biopsies is the Single, Strongest Predictive Factor for Post-Transplant Renal Function at 1 Year. In: 15th Annual Conference of the British Transplantation Society, Glasgow, UK, 22-24 Feb 2012,

McGuinness, D., Gingell-Littlejohn, M., Stevenson, K. S., Kingsmore, D. B., Clancy, M. and Shiels, P. G. (2012) MicroRNA Regulation of Cellular Bio-age Provides a Novel Pre-Transplant Prognostic and Predictive Assessment of Post Transplant Allograft Function. In: 15th Annual Conference of the British Transplantation Society, Glasgow, UK, 22-24 Feb 2012,

Shiels, P.G. (2012) CDKN2A might be better than telomere length in determining individual health status. British Medical Journal, 344, e1415. (doi: 10.1136/bmj.e1415)

2011

Carmona, F.D. et al. (2011) Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis. Annals of the Rheumatic Diseases, 70(11), pp. 2050-2052. (doi: 10.1136/ard.2010.148874)

Maxwell, F., McGlynn, L.M., Muir, H.C., Talwar, D., Benzeval, M., Robertson, T., Roxburgh, C.S., McMillan, D. , Horgan, P.G. and Shiels, P. (2011) Telomere attrition and decreased Fetuin A levels indicate accelerated biological ageing and are implicated in the pathogenesis of colorectal cancer. Clinical Cancer Research, 17(17), pp. 5573-5581. (doi: 10.1158/1078-0432.CCR-10-3271)

McGuinness, D., McGuinness, D.H. , McCaul, J. and Shiels, P.G. (2011) Sirtuins, bioageing, and cancer. Journal of Aging Research, 2011, 235754. (doi: 10.4061/2011/235754) (PMID:21766030) (PMCID:PMC3134127)

Bossini-Castillo, L. et al. (2011) A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort. Annals of the Rheumatic Diseases, 70(4), pp. 638-641. (doi: 10.1136/ard.2010.141838)

Birnie, K. et al. (2011) Childhood socioeconomic position and objectively measured physical capability levels in adulthood: a systematic review and meta-analysis. PLoS ONE, 6(1), e15564. (doi: 10.1371/journal.pone.0015564) (PMID:21297868) (PMCID:PMC3027621)

Bossini-Castillo, L. et al. (2011) Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population. Rheumatology, 50(11), pp. 1976-1981. (doi: 10.1093/rheumatology/ker259)

Gingell-Littlejohn, M., McGuinness, D., McGlynn, L. M., Kingsmore, D., Clancy, M. J., Koppelstaetter, C., Mayer, G. and Shiels, P.G. (2011) Telomere Length Impacts on Allograft Function Post Kidney Transplant. In: 2011 American Transplant Conference, Phildadelphia, PA, USA, 30 Apr - 4 May 2011,

McCarthy, M.I. et al. (2011) Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. PLoS Genetics, 7(7), e1002178. (doi: 10.1371/journal.pgen.1002178)

Packard, C.J. et al. (2011) Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study. BMC Public Health, 11, p. 42. (doi: 10.1186/1471-2458-11-42)

Shiels, P.G. et al. (2011) Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort. PLoS ONE, 6(7), e22521. (doi: 10.1371/journal.pone.0022521) (PMID:21818333) (PMCID:PMC3144896)

Stevenson, K. et al. (2011) Pancreatic derived pathfinder cells enable regeneration of critically damaged adult pancreatic tissue and completely reverse streptozotocin induced diabetes. Rejuvenation Research, 14(2), pp. 163-171. (doi: 10.1089/rej.2010.1099)

2010

Cooper, R., Kuh, D., Hardy, R. and Mortality Review Group on behalf of the FALCon and HALCyon study, (2010) Objectively measured physical capability levels and mortality: systematic review and meta-analysis. British Medical Journal, 341, c4467. (doi: 10.1136/bmj.c4467)

Elsberger, B., Fullerton, R., Zino, S., Jordan, F., Mitchell, T.J., Brunton, V.G., Mallon, E.A., Shiels, P.G. and Edwards, J. (2010) Breast cancer patients' clinical outcome measures are associated with Src kinase family member expression. British Journal of Cancer, 103(6), pp. 899-909. (doi: 10.1038/sj.bjc.6605829)

Cooper, R., Kuh, D., Cooper, C., Gale, C. R., Lawlor, D. A., Matthews, F., Hardy, R. and FALCon and HALCyon, S. T. (2010) Objective measures of physical capability and subsequent health: a systematic review. Age and Ageing, 40(1), pp. 14-23. (doi: 10.1093/ageing/afq117)

Radstake, T.R.D.J. et al. (2010) Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nature Genetics, 42(5), pp. 426-429. (doi: 10.1038/ng.565)

Shiels, P.G. (2010) Improving precision in investigating aging: why telomeres can cause problems. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 65A(8), pp. 789-791. (doi: 10.1093/gerona/glq095)

Simpson, R.J., Cosgrove, C., Chee, M.M., McFarlin, B.K., Bartlett, D.B., Spielmann, G., O'Connor, D.P., Pircher, H. and Shiels, P.G. (2010) Senescent phenotypes and telomere lengths of peripheral blood T-cells mobilized by acute exercise in humans. Exercise Immunology Review, 16, pp. 40-55.

2009

Stevenson, K.S., McGlynn, L.M., Hodge, M., McLinden, H., George, W.D., Davies, R.W. and Shiels, P.G. (2009) Isolation, characterization, and differentiation of Thy1.1-sorted pancreatic adult progenitor cell populations. Stem Cells and Development, 18(10), pp. 1389-1398. (doi: 10.1089/scd.2008.0301)

Stevenson, K.S., McGlynn, L.M. and Shiels, P.G. (2009) Stem cells: outstanding potential and outstanding questions. Scottish Medical Journal, 54(4), pp. 35-37. (doi: 10.1258/rsmsmj.54.4.35)

Batty, G.D., Wang, Y., Brouilette, S.W., Shiels, P.G., Packard, C.J., Moore, J., Samani, N.J. and Ford, I. (2009) Socioeconomic status and telomere length: the West of Scotland Coronary Prevention Study. Journal of Epidemiology and Community Health, 63(10), pp. 839-841. (doi: 10.1136/jech.2009.088427)

McGlynn, L.M., Stevenson, K., Lamb, K., Zino, S., Brown, M., Prina, A., Kingsmore, D. and Shiels, P.G. (2009) Cellular senescence in pre-transplant renal biopsies predicts postoperative organ function. Aging Cell, 8(1), pp. 45-51. (doi: 10.1111/j.1474-9726.2008.00447.x)

Deans, K.A. et al. (2009) Differences in atherosclerosis according to area level socioeconomic deprivation: cross sectional, population based study. British Medical Journal, 339, b4170. (doi: 10.1136/bmj.b4170)

El Fangour, S., Marini, M., Good, J., McQuaker, S.J., Shiels, P.G. and Hartley, R.C. (2009) Nitrones for understanding and ameliorating the oxidative stress associated with aging. Age, 31(4), pp. 269-276. (doi: 10.1007/s11357-009-9098-z) (PMID:19479343) (PMCID:PMC2813050)

Lamb, K.J. and Shiels, P.G. (2009) Telomeres, ageing and oxidation. In: Foyer, C.H., Faragher, R. and Thornally, P.J. (eds.) Redox Metabolism and Longevity Relationships in Animals and Plants. Series: SEB experimental biology series (62). Taylor and Francis: New York, USA, pp. 117-137. ISBN 9780415419543

2008

Maclntyre, A., Brouilette, S.W., Lamb, K., Radhakrishnan, K., McGlynn, L.M., Chee, M.M., Parkinson, E.K., Freeman, D., Madhok, R. and Shiels, P.G. (2008) Association of increased telomere lengths in limited scleroderma, with a lack of age-related telomere erosion. Annals of the Rheumatic Diseases, 67(12), pp. 1780-1782. (doi: 10.1136/ard.2007.086652)

Starr, J.M., Shiels, P.G. , Harris, S.E., Pattie, A., Pearce, M.S., Relton, C.L. and Deary, I.J. (2008) Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. Mechanisms of Ageing and Development, 129(12), pp. 745-751. (doi: 10.1016/j.mad.2008.09.020)

Carrero, J.J., Shiels, P.G. and Stenvinkel, P. (2008) Telomere biology alterations as a mortality risk factor in CKD. American Journal of Kidney Diseases, 51(6), pp. 1076-1077. (doi: 10.1053/j.ajkd.2008.02.367)

Stevenson, K.S., Radhakrishnan, K., Patterson, C.S., McMillan, L.C., Skeldon, K.D., Buist, L., Padgett, M. and Shiels, P.G. (2008) Breath ethane peaks during a single haemodialysis session and is associated with time on dialysis. Journal of Breath Research, 2(2), 026004. (doi: 10.1088/1752-7155/2/2/026004)

Carrero, J.J. et al. (2008) Telomere attrition is associated with inflammation, low fetuin-A levels and high mortality in prevalent haemodialysis patients. Journal of Internal Medicine, 263(3), pp. 302-312. (doi: 10.1111/j.1365-2796.2007.01890.x)

Chee, M.M., MacIntyre, A., Brouilette, S.W., Madhok, R. and Shiels, P.G. (2008) Association of increased telomere lengths in scleroderma with no age-related telomere erosion. Rheumatology, 47(Sup. 2), ii23. (doi: 10.1093/rheumatology/kem511)

Velupillai, Y.N. et al. (2008) Psychological, social and biological determinants of ill health (pSoBid): study protocol of a population-based study. BMC Public Health, 8(126), (doi: 10.1186/1471-2458-8-126)

2007

Patterson, C.S., McMillan, L.C., Stevenson, K., Radhakrishnan, K., Shiels, P.G. , Padgett, M. and Skeldon, K.D. (2007) Dynamic study of oxidative stress in renal dialysis patients based on breath ethane measured by optical spectroscopy. Journal of Breath Research, 1(2), 026005. (doi: 10.1088/1752-7155/1/2/026005)

Starr, J.M., McGurn, B., Harris, S.E., Whalley, L.J., Deary, I.J. and Shiels, P.G. (2007) Association between telomere length and heart disease in a narrow age cohort of older people. Experimental Gerontology, 42(6), pp. 571-573. (doi: 10.1016/j.exger.2006.12.002)

Al Kushi, A., Russell, D., Shiels, P.G., Davies, R.W. and Payne, A.P. (2007) Lewy-body protein immunoreactivity in the midbrain of a PKC-gamma mutant rat. Journal of Anatomy, 210(5), pp. 606-607.

Carrero, J.J. et al. (2007) Telomere shortening, a new mortality risk factor in dialysis patients. Associations with inflammatory markers and fetuin-a levels. Blood Purification, 25(4), p. 338.

Russell, D., Shiels, P.G. and Payne, A.P. (2007) Effects of the agu mutation on ageing and senescence in the brain and kidney in vivo. Journal of Anatomy, 210(5), pp. 624-625.

Stevenson, K. and Shiels, P.G. (2007) Cellular therapy for diabetes. Dumfries and Galloway Medical Journal, 5, pp. 7-13.

2006

Chen, D., Weber, M., Shiels, P.G. , Dong, R., Webster, Z., Mcvey, J.H., Kemball-Cook, G., Tuddenham, E.G.D., Lechler, R.I. and Dorling, A. (2006) Postinjury vascular intimal hyperplasia in mice is completely inhibited by CD34+bone marrow-derived progenitor cells expressing membrane-tethered anticoagulant fusion proteins. Journal of Thrombosis and Haemostasis, 4(10), pp. 2191-2198. (doi: 10.1111/j.1538-7836.2006.02100.x)

Harris, S.E., Deary, I.J., Maclntyre, A., Lamb, K.J., Radhakrishnan, K., Starr, J.M., Whalley, L.J. and Shiels, P.G. (2006) The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people. Neuroscience Letters, 406(3), pp. 260-264. (doi: 10.1016/j.neulet.2006.07.055)

Ashraf, N., Zino, S., MacIntyre, A., Kingsmore, D., Payne, A.P., George, W.D. and Shiels, P.G. (2006) Altered sirtuin expression is associated with node-positive breast cancer. British Journal of Cancer, 95, pp. 1056-1061. (doi: 10.1038/sj.bjc.6603384)

Lamb, K., Stevenson, K.S., Zino, S., MacIntyre, A., Kingsmore, D., Jardine, A.G., Marson, L., Forsyth, J.L.R. and Shiels, P.G. (2006) Telomere binding protein expression correlates with cold ischemic time and late graft dysfunction in human renal allografts, as a result of accelerated organ senescence. Nephrology Dialysis Transplantation, 21, pp. 259-260.

Nolan, C.E., Melin, J., Marson, L., Forsyth, J.L.R., Jardine, A.G. and Shiels, P.G. (2006) Insulin protects from accelerated senescence secondary to ischaemia/reperfusion injury in STZ diabetic rats. Nephrology Dialysis Transplantation, 21, p. 4.

Sklavounou, E., Hay, A., Ashraf, N., Lamb, K., Brown, E., Mac Intyre, A., George, W.D., Hartley, R.C. and Shiels, P.G. (2006) The use of telomere biology to identify and develop superior nitrone based anti-oxidants. Biochemical and Biophysical Research Communications, 347, pp. 420-427. (doi: 10.1016/j.bbrc.2006.06.087)

2005

Al-Fayez, M., Russell, D., Wayne Davies, R., Shiels, P.G. and Baker, P. (2005) Deficits in the mid-brain raphe nuclei and striatum of the AS/AGU rat, a protein kinase C-gamma mutant. European Journal of Neuroscience, 22(11), pp. 2792-2798. (doi: 10.1111/j.1460-9568.2005.04502.x)

Shiels, P.G. , Mac Intyre, A., Chen, D., Dorling, A., Deardon, D. and Subrimaniam, M. (2005) IV administration of adult stem cells mitigates STZ induced diabetes in a xenotransplant model. American Journal of Transplantation, 5(S11), p. 369. (doi: 10.1111/j.1600-6135.2005.authind.x)

Shiels, P.G. (2005) Adult stem cells mitigate the effects of STZ diabetes. Horizons in Medicine, 17, pp. 241-249.

2004

Chen, D.X., Giannopoulos, K., Shiels, P.G. , Webster, Z., Mcvey, J.H., Kemball-Cook, G., Tuddenham, E., Moore, M., Lechler, R. and Dorling, A. (2004) Inhibition of intravascular thrombosis in murine endotoxemia by targeted expression of hirudin and tissue factor pathway inhibitor analogs to activated endothelium. Blood, 104(5), pp. 1344-1349. (doi: 10.1182/blood-2003-12-4365)

Hillyard, D.Z., Cameron, A.J.M., McDonald, K.J., Thomson, J., MacIntyre, A., Shiels, P.G., Panarelli, M. and Jardine, A.G. (2004) Simvastatin inhibits lymphocyte function in normal subjects and patients with cardiovascular disease. Atherosclerosis, 175(2), pp. 305-313. (doi: 10.1016/j.atherosclerosis.2004.03.018)

Nolan, C.E., Wright, S.M. and Shiels, P.G. (2004) Senescence and transplantation. Transplant Topics, 15, pp. 6-9.

Shiels, P.G. and Davies, R.W. (2004) Ageing and death in neurones. In: Davies, R.W. and Morris, B.J. (eds.) Molecular Biology of the Neuron. Series: Molecular and cellular neurobiology series. Oxford University Press: Oxford, UK, pp. 435-464. ISBN 9780198509981

2003

Joosten, S.A., van Ham, V., Nolan, C.E., Borrias, M.C., Jardine, A.G. , Shiels, P.G. , van Kooten, C. and Paul, L.C. (2003) Telomere shortening and cellular senescence in a model of chronic renal allograft rejection. American Journal of Pathology, 162(4), pp. 1305-1312. (doi: 10.1016/S0002-9440(10)63926-0)

Shiels, P.G. and Jardine, A.G. (2003) Dolly, no longer the exception: Telomeres and implications for transplantation. Cloning Stem Cells, 5(2), pp. 157-160.

2001

Ayres, D., Colman, A., Dai, Y., Shiels, P.G. and Moore, M. (2001) Cloning pigs deficient in alpha 1,3 galactosyltransferase. Graft, 4, pp. 80-82.

Craig, N.J. et al. (2001) A candidate gene for human neurodegenerative disorders: a rat PKCγ mutation causes a Parkinsonian syndrome. Nature Neuroscience, 4, pp. 1061-1062. (doi: 10.1038/nn740)

2000

Shiels, P.G. (2000) Innovations conceptuelles et technologieques a l'aube du trosième millenaire. In: Dimanches biologiques de Lariboisière, Paris, 16-18 Nov 2000, pp. 73-80.

1999

Shiels, P.G. , Kind, A.J., Campbell, K.H.S., Wilmut, I., Waddington, D., Colman, A. and Schnieke, A.E. (1999) Analysis of telomere length in Dolly, a sheep derived by nuclear transfer. Cloning, 1(2), pp. 119-125. (doi: 10.1089/15204559950020003)

Shiels, P. (1999) Somatic cell nuclear transfer as a tool for investigating ageing processes in mammals. Gene Therapy and Molecular Biology, 4, pp. 11-22.

Shiels, P.G. , Kind, A.J., Campbell, K.H.S., Waddington, D., Wilmut, I., Colman, A. and Schnieke, A.E. (1999) Analysis of telomere lengths in cloned sheep. Nature, 399(6734), pp. 316-317. (doi: 10.1038/20580)

This list was generated on Wed Nov 20 19:19:42 2024 GMT.

Jump to: Articles | Book Sections | Conference or Workshop Item | Conference Proceedings

Number of items: 183.

Articles

Minnis, H. et al. (2024) The bio-exposome: intracellular processes, stress physiology and the environment. Nature Mental Health, 2(2), pp. 132-140. (doi: 10.1038/s44220-023-00180-3)

Shiels, P. G. (2023) ‘Debugging’ heart failure. Journal of Internal Medicine, 294(4), pp. 374-376. (doi: 10.1111/joim.13691) (PMID:37424184)

Mafra, D. et al. (2022) Archaea from the gut microbiota of humans: Could be linked to chronic diseases? Anaerobe, 77, 102629. (doi: 10.1016/j.anaerobe.2022.102629) (PMID:35985606)

Kooman, J. P., Stenvinkel, P. and Shiels, P. G. (2020) Fabry disease: a new model of premature aging? Nephron, 144(1), pp. 1-4. (doi: 10.1159/000503290) (PMID:31563917) (PMCID:PMC6979416)

McGuinness, D. et al. (2018) A molecular signature for delayed graft function. Aging Cell, 17(5), e12825. (doi: 10.1111/acel.12825) (PMID:30094915) (PMCID:PMC6156499)

Stenvinkel, P. et al. (2017) CDKN2A/p16INK4a expression is associated with vascular progeria in chronic kidney disease. Aging, 9(2), pp. 494-507. (doi: 10.18632/aging.101173) (PMID:28192277)

Ochoa, E. et al. (2015) Confirmation of CCR6 as a risk factor for anti-topoisomerase I antibodies in systemic sclerosis. Clinical and Experimental Rheumatology, 33(4Sup91), S31-S35. (PMID:26314374)

McGlynn, L.M. et al. (2014) SIRT2: Tumour suppressor or tumour promoter in operable breast cancer? European Journal of Cancer, 50(2), pp. 290-301. (doi: 10.1016/j.ejca.2013.10.005) (PMID:24183459)

Pathai, S. et al. (2013) Accelerated biological aging in HIV-infected individuals in South Africa: a case–control study. AIDS, 27(15), pp. 2375-2384. (doi: 10.1097/QAD.0b013e328363bf7f)

Shiels, P.G. (2012) CDKN2A might be better than telomere length in determining individual health status. British Medical Journal, 344, e1415. (doi: 10.1136/bmj.e1415)

Radstake, T.R.D.J. et al. (2010) Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nature Genetics, 42(5), pp. 426-429. (doi: 10.1038/ng.565)

Stevenson, K.S., McGlynn, L.M. and Shiels, P.G. (2009) Stem cells: outstanding potential and outstanding questions. Scottish Medical Journal, 54(4), pp. 35-37. (doi: 10.1258/rsmsmj.54.4.35)

Al Kushi, A., Russell, D., Shiels, P.G., Davies, R.W. and Payne, A.P. (2007) Lewy-body protein immunoreactivity in the midbrain of a PKC-gamma mutant rat. Journal of Anatomy, 210(5), pp. 606-607.

Carrero, J.J. et al. (2007) Telomere shortening, a new mortality risk factor in dialysis patients. Associations with inflammatory markers and fetuin-a levels. Blood Purification, 25(4), p. 338.

Russell, D., Shiels, P.G. and Payne, A.P. (2007) Effects of the agu mutation on ageing and senescence in the brain and kidney in vivo. Journal of Anatomy, 210(5), pp. 624-625.

Stevenson, K. and Shiels, P.G. (2007) Cellular therapy for diabetes. Dumfries and Galloway Medical Journal, 5, pp. 7-13.

Shiels, P.G. (2005) Adult stem cells mitigate the effects of STZ diabetes. Horizons in Medicine, 17, pp. 241-249.

Nolan, C.E., Wright, S.M. and Shiels, P.G. (2004) Senescence and transplantation. Transplant Topics, 15, pp. 6-9.

Shiels, P.G. and Jardine, A.G. (2003) Dolly, no longer the exception: Telomeres and implications for transplantation. Cloning Stem Cells, 5(2), pp. 157-160.

Ayres, D., Colman, A., Dai, Y., Shiels, P.G. and Moore, M. (2001) Cloning pigs deficient in alpha 1,3 galactosyltransferase. Graft, 4, pp. 80-82.

Craig, N.J. et al. (2001) A candidate gene for human neurodegenerative disorders: a rat PKCγ mutation causes a Parkinsonian syndrome. Nature Neuroscience, 4, pp. 1061-1062. (doi: 10.1038/nn740)

Shiels, P. (1999) Somatic cell nuclear transfer as a tool for investigating ageing processes in mammals. Gene Therapy and Molecular Biology, 4, pp. 11-22.

Ribeiro, M., Alvarenga, L., Cardozo, L. F. M. F., Kemp, J. A., Lima, L. S., de Almeida, J. S., Leal, V. d. O., Stenvinkel, P., Shiels, P. G. and Mafra, D. The magical smell and taste: Can coffee be good to patients with cardiometabolic disease? Critical Reviews in Food Science and Nutrition, 64(2), pp. 562-583. (doi: 10.1080/10408398.2022.2106938) (PMID:35930394)

Book Sections

Conference or Workshop Item

Conference Proceedings

Shiels, P.G. (2000) Innovations conceptuelles et technologieques a l'aube du trosième millenaire. In: Dimanches biologiques de Lariboisière, Paris, 16-18 Nov 2000, pp. 73-80.

This list was generated on Wed Nov 20 19:19:42 2024 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

A senescent cell specific senolytic delivery and release system
Office of the Chief Scientific Adviser
2024 - 2026
MINDSHIFT
European Commission
2021 - 2024
Mitigating the effects of vascular calcification in renal disease: a pilot study
NHS Greater Glasgow and Clyde Endowment Funds
2018 - 2019
Ageing, disease and the microbiome
4D Pharma
2018 - 2021
EpiStressNet: A biosocial systems approach to understanding the epigenetic embedding of social stress responses
Economic and Social Research Council and Biotechnology and Biological Sciences Research Council
2016 - 2018
research agreement manchester NHS foundation trust
Myeloma UK
2016 - 2018
Improving the outcome of patients with multiple myeloma through understanding the causes and effects of frailty
Myeloma UK
2016 - 2018
The association of exosomal markers of ageing with socioeconomic status and chronic inflammation
NHS Greater Glasgow and Clyde
2015 - 2017
Renal cell mitochondrial DNA deletions as a consequence of ageing and impact on outcome following renal transplantation
NHS Greater Glasgow and Clyde Endowment Funds
2015 - 2016
Why is fast growth costly, and what are the consequences for offspring viability?
Natural Environment Research Council
2013 - 2017
TC Biopharm
Glasgow City Council
2013 - 2015
Association of global DNA methylation with socioeconomic status, chronic inflammation and ageing
NHS Greater Glasgow and Clyde
2011 - 2012
Epigenetic regulation of CDKN2 locus in post-transplant renal allograft function
NHS Greater Glasgow and Clyde
2011 - 2012
The role of epigenetic regulation in colorectal cancer metastasis
NHS Greater Glasgow and Clyde
2011 - 2012
Research Award
Darlinda`s Charity for Renal Research
2011 - 2018
Epigenetics, biological ageing and oxidative stress in breast cancer
NHS Greater Glasgow and Clyde Endowment Funds
2010 - 2011
Role of epigenetics in predicting post transplant allograft function
NHS Greater Glasgow and Clyde Endowment Funds
2010 - 2011
Development of a predictive clinical pre transplant blood test for delayed graft function and post transplant organ dysfunction
Cunningham Trust
2010 - 2012
Evalutation of the potential role of mediators of biological ageing and cellular senescence in the pathogenesis of colorectal cancer
NHS Greater Glasgow and Clyde Endowment Funds
2010 - 2010
Pre transplant biological age as a prognostic indicator of post transplant allograft function
NHS Greater Glasgow and Clyde Endowment Funds
2010 - 2010
The role of telomere dynamics and epigenetic status in breast cancer
NHS Greater Glasgow and Clyde Endowment Funds
2010 - 2010
Pathfinder Cells Research
Darlinda`s Charity for Renal Research
2009 - 2010
A life course approach to healthy ageing: capitalising on the value of the UK life course cohorts
Economic and Social Research Council
2009 - 2010
Cellular senescence in renal transplantation
Cunningham Trust
2007 - 2009
Assay Technology - Renal Testing
Cunningham Trust
2006 - 2007
Assay Technology - Renal Testing
GU Innovation Fund
2006 - 2007
Pathfinder: A revolutionary therapy for diabetes, heart and cardiovascular damage and organ failure, POC 2005, Round 7
Scottish Enterprise
2006 - 2008
Telomere analysis in LBC
University of Edinburgh
2006 - 2006
Factors determining physical and mental well being in affluent and deprived communities in Glasgow
Glasgow Centre for Population Health
2005 - 2007
Assay Technology - Renal Testing
Scottish Enterprise
2004 - 2006
Cellular senescence in kidney transplantation
Cunningham Trust
2003 - 2005
Investigations into senescence as a predisposition factor to renal disease
Darlinda`s Charity for Renal Research
2003 - 2009

Research datasets

Jump to: 2020

Number of items: 1.

2020

Markopoulou, P., Panagiotou, N. , Li, A., Bueno-Perez, R., Madden, D., Buchanan, S., Fairen-Jimenez, D., Shiels, P. and Forgan, R. (2020) Identifying Differing Intracellular Cargo Release Mechanisms by Monitoring in vitro Drug Delivery from MOFs in Real Time. [Data Collection] (Unpublished)

This list was generated on Thu Nov 21 01:16:57 2024 GMT.

Paul Shiels

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Professor Paul Shiels

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2020